Detailed information for compound 58229

Basic information

Technical information
  • TDR Targets ID: 58229
  • Name: 7-chloro-4-(4-ethylpiperazin-1-yl)thieno[3,4- b][1,5]benzoxazepine
  • MW: 347.862 | Formula: C17H18ClN3OS
  • H donors: 0 H acceptors: 0 LogP: 3.11 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Oc2c1csc2
  • InChi: 1S/C17H18ClN3OS/c1-2-20-5-7-21(8-6-20)17-13-10-23-11-16(13)22-15-4-3-12(18)9-14(15)19-17/h3-4,9-11H,2,5-8H2,1H3
  • InChiKey: GQPZDRAJLVVZDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-4-(4-ethyl-1-piperazinyl)thieno[3,4-b][1,5]benzoxazepine
  • 7-chloro-4-(4-ethylpiperazino)thieno[3,4-b][1,5]benzoxazepine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0347 0.2174
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2775 0.3119 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0078 0.0067 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0448 0.0485 0.1556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0347 0.0347
Toxoplasma gondii ABC1 family protein 0.0036 0.002 0.0122
Schistosoma mansoni tyrosine kinase 0.403 0.454 0.4541
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica tyrosin kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Plasmodium vivax tyrosine kinase-like protein, putative 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase, putative 0.0052 0.0038 0.0237
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0078 0.0067 0.0067
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.007 0.0438
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.0264 0.1655
Brugia malayi Cathepsin L-like precursor 0.143 0.1597 0.1598
Leishmania major hypothetical protein, conserved 0.0078 0.0067 0.042
Echinococcus granulosus retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Echinococcus multilocularis geminin 0.0177 0.0179 0.0179
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0242 0.1512
Loa Loa (eye worm) TK/ABL protein kinase 0.0082 0.0071 0.0071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0982 0.109 0.3496
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0011 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0347 0.2174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0773 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.002 0.002
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0326 0.0347 0.2174
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0098 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0347 0.2174
Giardia lamblia Hypothetical protein 0.0326 0.0347 0.2883
Leishmania major cytochrome p450-like protein 0.0167 0.0168 0.1053
Leishmania major prefoldin subunit, putative 0.0063 0.005 0.0315
Onchocerca volvulus 0.0063 0.005 0.0295
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0326 0.0347 0.2174
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0326 0.0347 0.2174
Schistosoma mansoni tyrosine kinase 0.0085 0.0075 0.0075
Entamoeba histolytica serine/threonine kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis raf serine:threonine protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) fibroinase 0.143 0.1597 0.1598
Trypanosoma cruzi Protein kinase B 0.0035 0.0019 0.006
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Echinococcus granulosus activin receptor type 0.0081 0.007 0.007
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Brugia malayi Protein kinase domain containing protein 0.0604 0.0662 0.0662
Mycobacterium leprae putative cytochrome p450 0.0167 0.0168 1
Toxoplasma gondii cathepsin CPC2 0.0326 0.0347 0.2174
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.002 0.0814
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Echinococcus granulosus retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Receptor family ligand binding region containing protein 0.0078 0.0067 0.0067
Entamoeba histolytica receptor protein kinase, putative 0.0078 0.0067 0.042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.0012
Echinococcus granulosus tachykinin peptides receptor 99D 0.1498 0.1674 0.1674
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0326 0.0347 0.2174
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Mycobacterium leprae conserved hypothetical protein 0.0036 0.002 0.0712
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0167 0.0168 0.297
Brugia malayi beta-lactamase family protein 0.0036 0.002 0.002
Plasmodium falciparum protein kinase, putative 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.0326 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0167 0.0168 0.297
Trypanosoma cruzi aurora B kinase, putative 0.0252 0.0264 0.0847
Echinococcus multilocularis heat shock protein 70 0.0078 0.0067 0.0067
Plasmodium falciparum cysteine proteinase falcipain 1 0.0773 0.0854 0.5347
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0002 0.0006
Entamoeba histolytica serine/threonine kinase, putative 0.0078 0.0067 0.042
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0011 0.5
Echinococcus granulosus calpain 0.0021 0.0002 0.0002
Brugia malayi integrin-linked kinase 0.0078 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Onchocerca volvulus 0.0029 0.0012 0.0056
Schistosoma mansoni hypothetical protein 0.0036 0.0019 0.0019
Plasmodium falciparum serine repeat antigen 8 0.0326 0.0347 0.2174
Entamoeba histolytica tyrosin kinase, putative 0.0078 0.0067 0.042
Echinococcus granulosus tyrosine kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0078 0.0067 0.0067
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Loa Loa (eye worm) matrixin family protein 0.0052 0.0037 0.0037
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0035 0.0019 0.0019
Leishmania major protein kinase, putative 0.0081 0.007 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0029 0.0029
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0326 0.0347 0.2174
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0347 0.2174
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0326 0.0347 0.0347
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0002 0.0002
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0167 0.0168 0.702
Echinococcus multilocularis transfer RNA-Thr 0.0078 0.0067 0.0067
Entamoeba histolytica cysteine protease, putative 0.0326 0.0347 0.2174
Onchocerca volvulus 0.0036 0.002 0.0105
Brugia malayi serine/threonine-protein kinase 6 0.0252 0.0264 0.0264
Brugia malayi Tyrosine-protein kinase PR2 0.0078 0.0067 0.0067
Giardia lamblia Aurora kinase 0.0252 0.0264 0.2195
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Echinococcus multilocularis Glutaredoxin protein 5 0.0033 0.0016 0.0016
Giardia lamblia Encystation-specific protease 0.0326 0.0347 0.2883
Brugia malayi beta-lactamase 0.0036 0.002 0.002
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0085 0.0075 0.0075
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0002 0.0006
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0098 0.0098
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0019 0.0019
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Echinococcus granulosus prefoldin subunit 6 0.0063 0.005 0.005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0006
Brugia malayi protein-tyrosine kinase 0.0082 0.0071 0.0071
Schistosoma mansoni cathepsin B (C01 family) 0.0326 0.0347 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0019 0 0.0003
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Schistosoma mansoni protein kinase 0.0252 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.143 0.1597 0.1598
Echinococcus granulosus tyrosine protein kinase csk 0.0078 0.0067 0.0067
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0098 0.0313
Loa Loa (eye worm) TK/DDR protein kinase 0.0078 0.0067 0.0067
Giardia lamblia Cathepsin L precursor 0.0326 0.0347 0.2883
Entamoeba histolytica cysteine protease, putative 0.0326 0.0347 0.2174
Onchocerca volvulus 0.0082 0.0071 0.0429
Toxoplasma gondii protein kinase domain-containing protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Conserved protein 0.0036 0.002 0.0814
Entamoeba histolytica tyrosin kinase, putative 0.0078 0.0067 0.042
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0252 0.0264 0.1655
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.002 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0029 0.0029
Leishmania major protein kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2775 0.3119 0.312
Echinococcus granulosus serine/threonine protein kinase 0.0035 0.0019 0.0019
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Onchocerca volvulus Tyrosine kinase homolog 0.0078 0.0067 0.0403
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Echinococcus multilocularis General substrate transporter 0.0044 0.0028 0.0028
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0167 0.0168 0.297
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0011 0.0067
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0085 0.0075 0.0075
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Echinococcus granulosus natriuretic peptide receptor 1 0.0078 0.0067 0.0067
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0326 0.0347 0.2174
Echinococcus multilocularis nervana 2 0.0033 0.0016 0.0016
Plasmodium falciparum protein kinase, putative 0.0078 0.0067 0.042
Onchocerca volvulus 0.0326 0.0347 0.216
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Brugia malayi Sugar transporter family protein 0.0048 0.0033 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0029 0.0029
Schistosoma mansoni cathepsin S (C01 family) 0.0326 0.0347 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.002 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica cysteine protease, putative 0.0326 0.0347 0.2174
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.3951 0.4451 0.4453
Echinococcus granulosus cathepsin L cysteine protease 0.0773 0.0854 0.0854
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0078 0.0067 0.0067
Entamoeba histolytica cysteine protease, putative 0.0326 0.0347 0.2174
Loa Loa (eye worm) cysteine protease 0.143 0.1597 0.1598
Loa Loa (eye worm) CYP4Cod1 0.0519 0.0566 0.0567
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0167 0.0168 0.297
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0019 0.0019
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.143 0.1597 0.1598
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.002 0.0122
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi cathepsin L-like cysteine proteinase 0.0326 0.0347 0.0347
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0167 0.0168 0.702
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0098 0.0098
Brugia malayi Cytochrome P450 family protein 0.0245 0.0256 0.0257
Echinococcus granulosus retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0011 0.0067
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0326 0.0347 0.2174
Trichomonas vaginalis AGC family protein kinase 0.0252 0.0264 0.1655
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0326 0.0347 0.2174
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0043 0.0043
Trypanosoma brucei prefoldin subunit, putative 0.0063 0.005 0.0315
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Giardia lamblia Kinase, NEK 0.0078 0.0067 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0347 0.2174
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0167 0.0168 0.702
Loa Loa (eye worm) TK/INSR protein kinase 0.885 0.9996 1
Entamoeba histolytica cysteine surface protein, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0982 0.109 0.6827
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0347 0.2174
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Toxoplasma gondii cathepsin B 0.1083 0.1205 0.7542
Plasmodium falciparum serine repeat antigen 5 0.0326 0.0347 0.2174
Echinococcus multilocularis insulin receptor 0.885 0.9996 0.9996
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.143 0.1597 0.1597
Giardia lamblia Cathepsin B precursor 0.0326 0.0347 0.2883
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Brugia malayi ephrin receptor 1 precursor 0.0078 0.0067 0.0067
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0011 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.024 1
Trypanosoma cruzi cysteine peptidase, putative 0.143 0.1597 0.512
Brugia malayi cathepsin L-like precursor 0.0982 0.109 0.1091
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0011 0.1105
Toxoplasma gondii STE kinase 0.0078 0.0067 0.042
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0326 0.0347 0.2174
Plasmodium vivax vivapain-3 0.0773 0.0854 0.5347
Entamoeba histolytica ankyrin repeat protein 0.0078 0.0067 0.042
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Echinococcus multilocularis tyrosine protein kinase Srms 0.0082 0.0071 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/Met protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0326 0.0347 0.2174
Giardia lamblia Cysteine protease 0.0326 0.0347 0.2883
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0448 0.0485 0.0486
Trypanosoma cruzi protein kinase, putative 0.0078 0.0067 0.0215
Loa Loa (eye worm) calpain 0.0021 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0347 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0252 0.0264 0.1655
Echinococcus granulosus General substrate transporter 0.0044 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0063 0.005 0.005
Onchocerca volvulus 0.0078 0.0067 0.0403
Echinococcus granulosus fibroblast growth factor receptor 4 0.0078 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0082 0.0071 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0167 0.0168 0.702
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0029 0.0029
Brugia malayi SRC-1 0.0085 0.0075 0.0075
Onchocerca volvulus Cathepsin L homolog 0.143 0.1597 1
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus multilocularis FL cytokine receptor 0.0078 0.0067 0.0067
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0448 0.0485 0.0486
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.007 0.0224
Brugia malayi Protein kinase domain containing protein 0.0082 0.0071 0.0071
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0006
Schistosoma mansoni glucose transport protein 0.0048 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Entamoeba histolytica cysteine proteinase, putative 0.0773 0.0854 0.5347
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0078 0.0067 0.042
Entamoeba histolytica serine/threonine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0078 0.0067 0.0067
Echinococcus multilocularis epidermal growth factor receptor 0.403 0.454 0.454
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Onchocerca volvulus 0.0078 0.0067 0.0403
Onchocerca volvulus Cathepsin F homolog 0.143 0.1597 1
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0326 0.0347 0.0347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0029 0.0029
Echinococcus granulosus c src tyrosine kinase 0.0085 0.0075 0.0075
Onchocerca volvulus 0.0036 0.002 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.004 0.004
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Giardia lamblia Cathepsin B precursor 0.0326 0.0347 0.2883
Brugia malayi Protein kinase domain containing protein 0.885 0.9996 1
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0071 0.0071
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.007 0.0224
Brugia malayi fibroinase precursor 0.0326 0.0347 0.0347
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0167 0.0168 0.297
Echinococcus granulosus ephrin type A receptor 4 A 0.0078 0.0067 0.0067
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0002 0.0006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0773 0.0854 0.0854
Echinococcus granulosus tyrosine protein kinase Fyn 0.0085 0.0075 0.0075
Schistosoma mansoni tyrosine protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica cysteine proteinase, putative 0.0982 0.109 0.6827
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Mycobacterium ulcerans hypothetical protein 0.0036 0.002 0.0344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0029 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.0326 0.0347 0.0347
Entamoeba histolytica protein kinase, putative 0.0252 0.0264 0.1655
Echinococcus multilocularis 0.0167 0.0168 0.0168
Echinococcus multilocularis calpain 0.0021 0.0002 0.0002
Echinococcus granulosus aurora kinase A 0.0252 0.0264 0.0264
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0326 0.0347 0.2174
Loa Loa (eye worm) hypothetical protein 0.0982 0.109 0.1091
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2775 0.3119 0.312
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0012 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.005
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.005
Trichomonas vaginalis AGC family protein kinase 0.0019 0 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.002 0.0063
Loa Loa (eye worm) AGC/AKT protein kinase 0.0052 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0982 0.109 0.1091
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0078 0.0067 0.0067
Echinococcus granulosus tyrosine protein kinase Src64B 0.0085 0.0075 0.0075
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.002 0.002
Entamoeba histolytica cysteine protease, putative 0.0326 0.0347 0.2174
Schistosoma mansoni hypothetical protein 0.0063 0.005 0.005
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0012
Brugia malayi serine/threonine protein kinase 6 0.0252 0.0264 0.0264
Echinococcus multilocularis protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis tyrosine protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Echinococcus multilocularis cysteine protease 0.143 0.1597 0.1597
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni protein kinase 0.0081 0.007 0.007
Echinococcus multilocularis c src tyrosine kinase 0.0085 0.0075 0.0075
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0167 0.0168 0.297
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0167 0.0168 0.297
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Onchocerca volvulus 0.0082 0.0071 0.0429
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Giardia lamblia Cathepsin L precursor 0.0326 0.0347 0.2883
Echinococcus granulosus tyrosine protein kinase Lyn 0.0088 0.0078 0.0078
Echinococcus granulosus cathepsin L 0.0326 0.0347 0.0347
Entamoeba histolytica protein kinase, putative 0.0052 0.0038 0.0237
Entamoeba histolytica tyrosin kinase, putative 0.0078 0.0067 0.042
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0326 0.0347 0.2883
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0078 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0006 0.0039
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0078 0.0067 0.0067
Toxoplasma gondii facilitative glucose transporter GT1 0.0048 0.0033 0.0208
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni hypothetical protein 0.0177 0.0179 0.0179
Loa Loa (eye worm) calpain family protein 1 0.004 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.003 0.0013 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0347 0.2174
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0006 0.0039
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0011 0.5
Entamoeba histolytica protein kinase, putative 0.0252 0.0264 0.1655
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine kinase 0.885 0.9996 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Plasmodium vivax hexose transporter 0.0048 0.0033 0.0208
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.004 0.004
Brugia malayi Protein kinase domain containing protein 0.0082 0.0071 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0245 0.0256 0.0257
Leishmania major protein kinase, putative 0.0252 0.0264 0.1655
Trypanosoma brucei rac serine-threonine kinase, putative 0.0052 0.0038 0.0237
Trichomonas vaginalis AGC family protein kinase 0.0252 0.0264 0.1655
Brugia malayi hypothetical protein 0.0024 0.0006 0.0006
Plasmodium vivax prefoldin subunit 6, putative 0.0063 0.005 0.0315
Echinococcus granulosus activated cdc42 kinase 1 0.0078 0.0067 0.0067
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.002 0.002
Schistosoma mansoni cathepsin s 0.0448 0.0485 0.0486
Onchocerca volvulus 0.143 0.1597 1
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Giardia lamblia Cathepsin B precursor 0.0326 0.0347 0.2883
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0167 0.0168 0.297
Echinococcus multilocularis nervana 2 0.0033 0.0016 0.0016
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0003
Onchocerca volvulus 0.0078 0.0067 0.0403
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.002 0.0344
Echinococcus granulosus activated cdc42 kinase 1 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0167 0.0168 0.702
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Echinococcus multilocularis cathepsin b 0.2775 0.3119 0.3119
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0078 0.0067 0.0067
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis protein kinase atn1, putative 0.0078 0.0067 0.042
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0078 0.0067 0.0067
Trypanosoma brucei cytochrome P450, putative 0.0519 0.0566 0.3547
Onchocerca volvulus 0.143 0.1597 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0167 0.0168 0.702
Echinococcus multilocularis 0.1155 0.1286 0.1286
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0006 0.0039
Trichomonas vaginalis STE family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/ALK protein kinase 0.0603 0.0662 0.0662
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.0122
Onchocerca volvulus 0.0078 0.0067 0.0403
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus granulosus kinase suppressor of Ras 1 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0326 0.0347 0.2174
Trichomonas vaginalis protein tyrosine kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0347 0.2174
Trypanosoma cruzi cruzipain precursor, putative 0.143 0.1597 0.512
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Brugia malayi Papain family cysteine protease containing protein 0.0773 0.0854 0.0854
Entamoeba histolytica protein kinase 2, putative 0.0035 0.0019 0.0118
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.002 0.0814
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0167 0.0168 0.297
Trypanosoma brucei antigen, putative 0.0021 0.0002 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Giardia lamblia Cathepsin L-like protease 0.0326 0.0347 0.2883
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0006 0.002
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0078 0.0067 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.0519 0.0566 0.1816
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0773 0.0854 0.5347
Echinococcus multilocularis cysteine protease 0.143 0.1597 0.1597
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0326 0.0347 0.0347
Plasmodium falciparum cysteine proteinase falcipain 2a 0.143 0.1597 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Brugia malayi 6-phosphofructokinase 0.0105 0.0098 0.0098
Schistosoma mansoni tyrosine kinase 0.3951 0.4451 0.4453
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0167 0.0168 0.297
Echinococcus granulosus insulin receptor 0.885 0.9996 0.9996
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0082 0.0071 0.0071
Plasmodium falciparum tyrosine kinase-like protein 0.0078 0.0067 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.002 0.0122
Echinococcus granulosus receptor type guanylyl cyclase 0.0078 0.0067 0.0067
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0011 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Onchocerca volvulus 0.143 0.1597 1
Onchocerca volvulus 0.0232 0.0242 0.1497
Entamoeba histolytica serine/threonine kinase, putative 0.0078 0.0067 0.042
Echinococcus granulosus epidermal growth factor receptor 0.403 0.454 0.454
Echinococcus granulosus calpain 5 0.0021 0.0002 0.0002
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica hypothetical protein, conserved 0.0078 0.0067 0.042
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0082 0.0071 0.0071
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0167 0.0168 0.297
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0347 0.0347
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0085 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.403 0.454 0.4541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0519 0.0566 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0002 0.0012
Brugia malayi hypothetical protein 0.0036 0.0019 0.0019
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0078 0.0067 0.042
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0167 0.0168 0.702
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0098 0.5584
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0006 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.143 0.1597 0.1598
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0019 0.006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0448 0.0485 0.0486
Brugia malayi p70 ribosomal S6 kinase beta 0.0052 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase csk 0.0078 0.0067 0.0067
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Plasmodium vivax vivapain-2 0.143 0.1597 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0082 0.0071 0.0071
Echinococcus multilocularis hypothetical protein 0.0021 0.0002 0.0002
Entamoeba histolytica ankyrin repeat protein 0.0078 0.0067 0.042
Brugia malayi Cathepsin L-like precursor 0.0982 0.109 0.1091
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Plasmodium falciparum serine repeat antigen 6 0.0326 0.0347 0.2174
Loa Loa (eye worm) matrix metalloproteinase 0.0021 0.0003 0.0003
Loa Loa (eye worm) TK/EGFR protein kinase 0.403 0.454 0.4541
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.002 0.0814
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Trypanosoma cruzi protein kinase, putative 0.0078 0.0067 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0347 0.2174
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0098 0.0611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis receptor type guanylyl cyclase 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0462 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0982 0.109 0.6827
Trypanosoma cruzi cysteine peptidase, putative 0.143 0.1597 0.512
Loa Loa (eye worm) TK protein kinase 0.0082 0.0071 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Echinococcus granulosus tyrosine protein kinase Blk 0.0082 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.002 0.0122
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Brugia malayi Papain family cysteine protease containing protein 0.0326 0.0347 0.0347
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Loa Loa (eye worm) AUR protein kinase 0.0252 0.0264 0.0264
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0085 0.0075 0.0075
Brugia malayi Furin-like cysteine rich region family protein 0.403 0.454 0.4541
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.143 0.1597 1
Giardia lamblia Cysteine protease 0.0326 0.0347 0.2883
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0252 0.0264 0.1655
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Plasmodium vivax vivapain-1 0.0773 0.0854 0.5347
Brugia malayi calpain 7 0.0021 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0043 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0098 0.0611
Echinococcus multilocularis cathepsin L cysteine protease 0.143 0.1597 0.1597
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0019 0.0019
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Brugia malayi hypothetical protein 0.0082 0.0071 0.0071
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0078 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0082 0.0071 0.0071
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0098 0.0098
Brugia malayi Cathepsin L-like precursor 0.143 0.1597 0.1598
Echinococcus granulosus cathepsin L cysteine proteinase 0.143 0.1597 0.1597
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0252 0.0264 0.0264
Brugia malayi cathepsin F-like cysteine proteinase 0.0326 0.0347 0.0347
Giardia lamblia Cysteine protease 0.0326 0.0347 0.2883
Onchocerca volvulus 0.143 0.1597 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0078 0.0067 0.042
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0167 0.0168 0.297
Leishmania major hypothetical protein, conserved 0.0036 0.002 0.0122
Onchocerca volvulus 0.0082 0.0071 0.0429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Onchocerca volvulus 0.0078 0.0067 0.0403
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0011 0.0067
Echinococcus multilocularis tyrosine protein kinase csk 0.0078 0.0067 0.0067
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0078 0.0067 0.0067
Plasmodium falciparum prefoldin subunit 6, putative 0.0063 0.005 0.0315
Schistosoma mansoni cathepsin F (C01 family) 0.143 0.1597 0.1598
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0002 0.0012
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0078 0.0067 0.0067
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0011 0.0067
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.002 0.0122
Echinococcus granulosus cathepsin l1 0.0982 0.109 0.109
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.002 0.0122
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0098 0.1722
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0024 0.0024
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis tyrosine protein kinase Blk 0.0082 0.0071 0.0071
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0167 0.0168 0.297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0167 0.0168 0.702
Echinococcus granulosus Glutaredoxin protein 5 0.0033 0.0016 0.0016
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0078 0.0067 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0012 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0011 0.0067
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0021 0.0003 0.0003
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0098 0.0098
Trypanosoma brucei Pseudokinase, putative 0.0078 0.0067 0.042
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0326 0.0347 0.2174
Echinococcus multilocularis calpain A 0.0057 0.0043 0.0043
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0019 0.006
Trypanosoma brucei cysteine peptidase C (CPC) 0.1083 0.1205 0.7542
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Trypanosoma cruzi cysteine peptidase, putative 0.0773 0.0854 0.2738
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Onchocerca volvulus 0.0034 0.0017 0.0089
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0326 0.0347 0.2174
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/ACK protein kinase 0.0078 0.0067 0.0067
Brugia malayi phosphofructokinase 0.0105 0.0098 0.0098
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.002 0.0344
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trypanosoma brucei aurora B kinase 0.0252 0.0264 0.1655
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0035 0.0019 0.0118
Onchocerca volvulus 0.143 0.1597 1
Brugia malayi cathepsin L precursor 0.0326 0.0347 0.0347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0167 0.0168 0.702
Loa Loa (eye worm) ctsf protein 0.143 0.1597 0.1598
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.0326 0.0347 0.0347
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0252 0.0264 0.1655
Loa Loa (eye worm) protein kinase domain-containing protein 0.0078 0.0067 0.0067
Toxoplasma gondii cytochrome p450 superfamily protein 0.0167 0.0168 0.1053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0003
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0011 0.0067
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0167 0.0168 0.0539
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0252 0.0264 0.0264
Loa Loa (eye worm) SRC-1 0.0085 0.0075 0.0075
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0326 0.0347 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0773 0.0854 0.5347
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0167 0.0168 0.297
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0982 0.109 0.1091
Echinococcus multilocularis tyrosine kinase 0.0082 0.0071 0.0071
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0078 0.0067 0.0403
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trypanosoma cruzi cysteine proteinase, putative 0.0773 0.0854 0.2738
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1083 0.1205 0.7542
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0029 0.0029
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0098 0.0611
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1083 0.1205 0.7542
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0011 0.0067
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0098 0.0098
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0002 0.0006
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Mycobacterium ulcerans hydrolase 0.0026 0.0008 0.0143
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0078 0.0067 0.042
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0078 0.0067 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Plasmodium vivax hypothetical protein, conserved 0.0036 0.002 0.0122
Trichomonas vaginalis AGC family protein kinase 0.0252 0.0264 0.1655
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0098 0.0098
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0326 0.0347 0.2174
Giardia lamblia Cathepsin L-like protease 0.0326 0.0347 0.2883
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0326 0.0347 0.0347
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Brugia malayi SH2 domain containing protein 0.0082 0.0071 0.0071
Echinococcus granulosus tyrosine protein kinase Srms 0.0082 0.0071 0.0071
Brugia malayi Protein kinase domain containing protein 0.0052 0.0038 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0167 0.0168 0.702
Loa Loa (eye worm) TK/FAK protein kinase 0.0896 0.0993 0.0993
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Echinococcus granulosus serine threonine protein kinase nrc 0.0035 0.0019 0.0019
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0019 0 0.0003
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0002 0.0012
Brugia malayi Guanylyl cyclase protein 23 0.0078 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Schistosoma mansoni protein kinase 0.0081 0.007 0.007
Brugia malayi Raf kinase 0.0078 0.0067 0.0067
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Schistosoma mansoni serine/threonine RGC 0.0078 0.0067 0.0067
Trypanosoma cruzi prefoldin subunit, putative 0.0063 0.005 0.0161
Onchocerca volvulus 0.0082 0.0071 0.0429
Echinococcus multilocularis epidermal growth factor receptor 0.403 0.454 0.454
Plasmodium falciparum serine repeat antigen 3 0.0326 0.0347 0.2174
Plasmodium vivax unspecified product 0.0773 0.0854 0.5347
Toxoplasma gondii aurora kinase 0.0252 0.0264 0.1655
Echinococcus granulosus tyrosine protein kinase csk 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0082 0.0071 0.0071
Schistosoma mansoni tyrosine kinase 0.0085 0.0075 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0326 0.0347 0.0347
Brugia malayi hypothetical protein 0.0078 0.0067 0.0067
Giardia lamblia Cathepsin L precursor 0.0326 0.0347 0.2883
Echinococcus granulosus tyrosine protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0078 0.0067 0.042
Echinococcus granulosus tyrosine protein kinase Fyn 0.0085 0.0075 0.0075
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0085 0.0075 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0167 0.0168 0.702
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0167 0.0168 0.297
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine kinase 0.0085 0.0075 0.0075
Entamoeba histolytica receptor protein kinase, putative 0.0078 0.0067 0.042
Onchocerca volvulus Cathepsin L homolog 0.0326 0.0347 0.216
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0035 0.0019 0.0019
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0252 0.0264 0.1655
Echinococcus multilocularis activin receptor type 0.0081 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.0896 0.0993 0.0993
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Onchocerca volvulus 0.143 0.1597 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0085 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0347 0.2174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Echinococcus granulosus tyrosine protein kinase Src42A 0.0085 0.0075 0.0075
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0078 0.0067 0.042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0078 0.0067 0.0067
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0773 0.0854 0.2738
Onchocerca volvulus 0.0078 0.0067 0.0403
Echinococcus granulosus protein kinase 0.0078 0.0067 0.0067
Echinococcus granulosus tyrosine protein kinase Fyn 0.0085 0.0075 0.0075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0085 0.0075 0.0075
Entamoeba histolytica cysteine proteinase 1, putative 0.0773 0.0854 0.5347
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Brugia malayi Cathepsin L-like cysteine proteinase 0.0982 0.109 0.1091
Plasmodium falciparum serine repeat antigen 7 0.0326 0.0347 0.2174
Toxoplasma gondii protein kinase 0.0078 0.0067 0.042
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0032 0.0185
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Schistosoma mansoni hypothetical protein 0.0078 0.0067 0.0067
Echinococcus multilocularis MAM 0.0063 0.005 0.005
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0098 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.0012
Giardia lamblia Cysteine protease 0.0326 0.0347 0.2883
Echinococcus granulosus calpain A 0.0057 0.0043 0.0043
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0039
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0011 0.0067
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.005
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0167 0.0168 0.702
Schistosoma mansoni tyrosine kinase 0.885 0.9996 1
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Giardia lamblia Protein 21.1 0.0078 0.0067 0.0557
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0167 0.0168 0.297
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0003
Onchocerca volvulus 0.0982 0.109 0.6822
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0011 0.0067
Plasmodium falciparum protein kinase, putative 0.0081 0.007 0.0438
Echinococcus multilocularis cathepsin l cysteine peptidase 0.143 0.1597 0.1597
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0085 0.0075 0.0075
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.002 0.0814
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0003
Giardia lamblia Hypothetical protein 0.0326 0.0347 0.2883
Plasmodium falciparum serine repeat antigen 9 0.0326 0.0347 0.2174
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine kinase 0.0085 0.0075 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0006
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Plasmodium falciparum cysteine proteinase falcipain 2b 0.143 0.1597 1
Echinococcus granulosus tyrosine kinase 0.0082 0.0071 0.0071
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.002 0.0814
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0078 0.0067 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0773 0.0854 0.0854
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0098 0.0611
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0078 0.0067 0.0067
Onchocerca volvulus 0.0082 0.0071 0.0429
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0326 0.0347 0.2174
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Echinococcus granulosus tyrosine protein kinase shark 0.0082 0.0071 0.0071
Giardia lamblia Cathepsin L precursor 0.0326 0.0347 0.2883
Loa Loa (eye worm) AUR protein kinase 0.0252 0.0264 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Echinococcus multilocularis calpain 5 0.0021 0.0002 0.0002
Echinococcus multilocularis aurora kinase A 0.0252 0.0264 0.0264
Echinococcus granulosus cathepsin L 0.0773 0.0854 0.0854
Giardia lamblia Hypothetical protein 0.0063 0.005 0.0418
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Plasmodium falciparum serine repeat antigen 1 0.0326 0.0347 0.2174
Mycobacterium tuberculosis Conserved protein 0.0036 0.002 0.0814
Onchocerca volvulus 0.0036 0.002 0.0105
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Brugia malayi Cathepsin L-like precursor 0.143 0.1597 0.1598
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0019 0.0118
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0085 0.0075 0.0075
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0078 0.0067 0.0067
Echinococcus granulosus cathepsin l cysteine peptidase 0.143 0.1597 0.1597
Entamoeba histolytica protein kinase , putative 0.0252 0.0264 0.1655
Giardia lamblia Cathepsin L precursor 0.0326 0.0347 0.2883
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0081 0.007 0.0438
Mycobacterium leprae Conserved hypothetical protein 0.0167 0.0168 1
Echinococcus granulosus cathepsin b 0.2775 0.3119 0.3119
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0167 0.0168 0.702
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0081 0.007 0.007
Plasmodium vivax protein kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0326 0.0347 0.2174
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0003
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Trypanosoma cruzi major cysteine proteinase, putative 0.0326 0.0347 0.1113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0326 0.0347 0.0347
Brugia malayi Pre-SET motif family protein 0.0029 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0352 0.0377 0.0377
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0167 0.0168 0.0539
Brugia malayi Protein kinase domain containing protein 0.4899 0.5524 0.5526
Schistosoma mansoni ephrin receptor 0.0078 0.0067 0.0067
Echinococcus multilocularis integrin linked protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.0881 0.0881
Brugia malayi hypothetical protein 0.0078 0.0067 0.0067
Trypanosoma cruzi cysteine proteinase, putative 0.0773 0.0854 0.2738
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.143 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.0485 0.0486
Echinococcus multilocularis kinase suppressor of Ras 1 0.0078 0.0067 0.0067
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0326 0.0347 0.0347
Echinococcus multilocularis protein KINase family member (kin 25) 0.0078 0.0067 0.0067
Onchocerca volvulus Cathepsin L homolog 0.143 0.1597 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0078 0.0067 0.0067
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1083 0.1205 0.3862
Echinococcus granulosus cytochrome P450 2K1 0.0167 0.0168 0.0168
Brugia malayi Cathepsin L-like precursor 0.0448 0.0485 0.0486
Echinococcus multilocularis cathepsin b 0.2775 0.3119 0.3119
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.403 0.454 0.454
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0085 0.0075 0.0075
Onchocerca volvulus 0.0078 0.0067 0.0403
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Plasmodium falciparum tyrosine kinase-like protein 0.0078 0.0067 0.042
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0167 0.0168 0.702
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0008 0.0339
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0347 0.0347
Echinococcus multilocularis protein kinase 0.0078 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.0264 0.0264
Schistosoma mansoni cathepsin C 0.0326 0.0347 0.0347
Onchocerca volvulus 0.0082 0.0071 0.0429
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Cathepsin L-like precursor 0.143 0.1597 0.1598
Giardia lamblia Cathepsin B precursor 0.0326 0.0347 0.2883
Brugia malayi serine/threonine kinase 12 0.0252 0.0264 0.0264
Plasmodium vivax serine-repeat antigen (SERA) 0.0326 0.0347 0.2174
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0002 0.0002
Brugia malayi Matrixin family protein 0.0052 0.0037 0.0037
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Brugia malayi Cathepsin L-like precursor 0.143 0.1597 0.1598
Loa Loa (eye worm) hypothetical protein 0.004 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Plasmodium vivax vivapain-2 0.143 0.1597 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.002 0.0344
Brugia malayi Cathepsin L-like precursor 0.0982 0.109 0.1091
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0067 0.0067
Echinococcus granulosus nervana 2 0.0033 0.0016 0.0016
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0078 0.0067 0.0067
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0078 0.0067 0.0067
Brugia malayi SH2 domain containing protein 0.0082 0.0071 0.0071
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0012
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.0122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2775 0.3119 0.312
Loa Loa (eye worm) serine/threonine protein kinase 0.0078 0.0067 0.0067
Giardia lamblia Kinase, NEK 0.0078 0.0067 0.0557
Loa Loa (eye worm) hypothetical protein 0.0448 0.0485 0.0486
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.8853 1 1
Plasmodium vivax unspecified product 0.0448 0.0485 0.3039
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0035 0.0019 0.0118
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Brugia malayi C-terminal src kinase protein 1 0.0078 0.0067 0.0067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0326 0.0347 0.0347
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus granulosus integrin linked protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0067 0.042
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0167 0.0168 0.702
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0002 0.0002
Brugia malayi cathepsin Z-like cysteine proteinase 0.0326 0.0347 0.0347
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0326 0.0347 0.2174
Loa Loa (eye worm) cathepsin B 0.1083 0.1205 0.1205
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0167 0.0168 0.702
Giardia lamblia Cathepsin L precursor 0.0326 0.0347 0.2883
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0167 0.0168 0.702
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.002 0.0814
Echinococcus granulosus tyrosine protein kinase HCK 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Loa Loa (eye worm) AUR protein kinase 0.0252 0.0264 0.0264
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0167 0.0168 0.1053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Trichomonas vaginalis TK family protein kinase 0.0078 0.0067 0.042
Trypanosoma cruzi cytochrome P450, putative 0.0519 0.0566 0.1816
Loa Loa (eye worm) TK/RYK protein kinase 0.0078 0.0067 0.0067
Brugia malayi cytochrome P450 0.0167 0.0168 0.0168
Trypanosoma brucei protein kinase, putative 0.0081 0.007 0.0438
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Entamoeba histolytica serine/threonine kinase, putative 0.0078 0.0067 0.042
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0002 0.0002
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0033 0.0016 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.002 0.002
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0078 0.0067 0.0067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.021 0.021
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0078 0.0067 0.0067
Brugia malayi beta-lactamase family protein 0.0036 0.002 0.002
Echinococcus multilocularis ephrin type A receptor 4 A 0.0078 0.0067 0.0067
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0002 0.0012
Loa Loa (eye worm) calpain family protein 1 0.0055 0.004 0.004
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Echinococcus multilocularis cathepsin L cysteine protease 0.143 0.1597 0.1597
Schistosoma mansoni tyrosine kinase 0.403 0.454 0.4541
Mycobacterium leprae Probable lipase LipE 0.0036 0.002 0.0712
Entamoeba histolytica cysteine proteinase, putative 0.143 0.1597 1
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Echinococcus granulosus geminin 0.0177 0.0179 0.0179
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0048 0.0033 0.0033
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0078 0.0067 0.0403
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0052 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0773 0.0854 0.5347
Loa Loa (eye worm) papain family cysteine protease containing protein 0.143 0.1597 0.1598
Brugia malayi Pre-SET motif family protein 0.0204 0.021 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0773 0.0854 0.5347
Schistosoma mansoni hypothetical protein 0.0167 0.0168 0.0168
Toxoplasma gondii cathepsin CPL 0.143 0.1597 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0167 0.0168 0.297
Giardia lamblia Cathepsin B precursor 0.1083 0.1205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0347 0.2174
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus multilocularis tyrosine protein kinase Abl 0.0085 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0773 0.0854 0.5347
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0038 0.0237
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0002 0.0002
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0078 0.0067 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0326 0.0347 0.2174
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0167 0.0168 0.1053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0326 0.0347 0.0347
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0078 0.0067 0.0067
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0082 0.0071 0.0071
Toxoplasma gondii cathepsin CPC1 0.0326 0.0347 0.2174
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0033 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0098 0.0611
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0085 0.0075 0.0075
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0078 0.0067 0.042
Entamoeba histolytica serine/threonine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0002 0.0006
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Leishmania major cytochrome p450-like protein 0.0167 0.0168 0.1053
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Brugia malayi 6-phosphofructokinase 0.0105 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0048 0.0033 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Brugia malayi Cathepsin L-like precursor 0.143 0.1597 0.1598
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) hypothetical protein 0.2775 0.3119 0.312
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0078 0.0067 0.042
Loa Loa (eye worm) TK/CSK protein kinase 0.0078 0.0067 0.0067
Trypanosoma cruzi major cysteine proteinase, putative 0.0326 0.0347 0.1113
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0167 0.0168 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.005 0.0315
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0098 0.0098
Echinococcus multilocularis prefoldin subunit 6 0.0063 0.005 0.005
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2775 0.3119 0.312
Entamoeba histolytica hypothetical protein 0.0078 0.0067 0.042
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Giardia lamblia Kinase, AGC PKA 0.0035 0.0019 0.0156
Onchocerca volvulus 0.0078 0.0067 0.0403
Loa Loa (eye worm) TK/ROR protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Echinococcus multilocularis protein tyrosine kinase 0.0886 0.0982 0.0982
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0085 0.0075 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0019 0 0.0003
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0098 1
Loa Loa (eye worm) TK/FER protein kinase 0.0082 0.0071 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Echinococcus granulosus protein tyrosine kinase 0.0886 0.0982 0.0982
Brugia malayi Tyrosine-protein kinase abl-1 0.0085 0.0075 0.0075
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0081 0.007 0.007
Plasmodium falciparum cysteine proteinase falcipain 3 0.143 0.1597 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0347 0.0347
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0326 0.0347 0.2174
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0167 0.0168 0.297
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0167 0.0168 0.702
Brugia malayi cathepsin B-like cysteine proteinase 0.2775 0.3119 0.312
Echinococcus granulosus epidermal growth factor receptor 0.403 0.454 0.454
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Trypanosoma cruzi cruzipain precursor, putative 0.0448 0.0485 0.1556
Onchocerca volvulus 0.143 0.1597 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0326 0.0347 0.2174
Loa Loa (eye worm) beta-lactamase 0.0036 0.002 0.002
Giardia lamblia Cathepsin B precursor 0.1083 0.1205 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0326 0.0347 0.2174
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0063 0.005 0.005
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0078 0.0067 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0326 0.0347 0.2174
Trypanosoma cruzi cysteine peptidase, putative 0.143 0.1597 0.512
Schistosoma mansoni tyrosine kinase 0.0082 0.0071 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0519 0.0566 0.0567
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0011 0.0089
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0067 0.042
Loa Loa (eye worm) TK protein kinase 0.0078 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0886 0.0982 0.0982
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0002 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.143 0.1597 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0011 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Trypanosoma cruzi cysteine peptidase, putative 0.143 0.1597 0.512
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0773 0.0854 0.0854
Onchocerca volvulus Matrilysin homolog 0.0047 0.0032 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Brugia malayi Cytochrome P450 family protein 0.0519 0.0566 0.0567
Onchocerca volvulus 0.0078 0.0067 0.0403
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0326 0.0347 0.2883
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1498 0.1674 0.1674
Brugia malayi Cytochrome P450 family protein 0.0167 0.0168 0.0168
Echinococcus granulosus tyrosine kinase 0.0082 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.4821 0.5435 0.5437
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0167 0.0168 0.297
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0006 0.002
Schistosoma mansoni tyrosine kinase 0.0078 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Entamoeba histolytica protein kinase, putative 0.0078 0.0067 0.042
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0082 0.0071 0.0446
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0019 0.0019
Echinococcus granulosus calpain A 0.0021 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0082 0.0071 0.0071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1083 0.1205 0.1205
Echinococcus granulosus raf serine:threonine protein kinase 0.0078 0.0067 0.0067
Plasmodium vivax SET domain protein, putative 0.0029 0.0012 0.0074
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0011 0.0067
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0347 0.2174
Mycobacterium ulcerans lipase LipD 0.0036 0.002 0.0344
Brugia malayi Papain family cysteine protease containing protein 0.143 0.1597 0.1598
Brugia malayi Papain family cysteine protease containing protein 0.0326 0.0347 0.0347
Plasmodium vivax calpain, putative 0.0021 0.0002 0.0012
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0326 0.0347 0.2883
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0006 0.0039
Entamoeba histolytica cysteine protease, putative 0.143 0.1597 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0078 0.0067 0.0067
Schistosoma mansoni protein kinase 0.0081 0.007 0.007
Brugia malayi KE2 family protein 0.0063 0.005 0.005
Trypanosoma cruzi cysteine protease, putative 0.0773 0.0854 0.2738
Giardia lamblia Cathepsin B precursor 0.0326 0.0347 0.2883
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0078 0.0067 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0011 0.0067
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0167 0.0168 0.297
Brugia malayi Cytochrome P450 family protein 0.0519 0.0566 0.0567
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0067 0.0067
Onchocerca volvulus 0.0066 0.0053 0.0318
Brugia malayi calpain family protein 1 0.0055 0.004 0.004
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0098 0.0611
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0098 0.407
Entamoeba histolytica prefoldin subunit 6, putative 0.0063 0.005 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Echinococcus multilocularis cathepsin L 0.0326 0.0347 0.0347
Entamoeba histolytica protein kinase domain containing protein 0.0081 0.007 0.0438
Trypanosoma brucei Flagellum attachment zone protein 20 0.0078 0.0067 0.042
Entamoeba histolytica tyrosine kinase, putative 0.0078 0.0067 0.042
Echinococcus multilocularis tyrosine protein kinase csk 0.0078 0.0067 0.0067
Mycobacterium tuberculosis Conserved protein 0.0036 0.002 0.0814
Echinococcus multilocularis tyrosine protein kinase HCK 0.0078 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Echinococcus granulosus cysteine protease 0.0773 0.0854 0.0854
Schistosoma mansoni protein tyrosine kinase 0.0078 0.0067 0.0067
Plasmodium falciparum serine repeat antigen 4 0.0326 0.0347 0.2174
Echinococcus granulosus tyrosine protein kinase ABL1 0.0082 0.0071 0.0071
Schistosoma mansoni tyrosine kinase 0.3951 0.4451 0.4453
Brugia malayi Papain family cysteine protease containing protein 0.0326 0.0347 0.0347
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Schistosoma mansoni ephrin receptor 0.0081 0.0071 0.0071
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0082 0.0071 0.0071
Giardia lamblia Cathepsin B precursor 0.1083 0.1205 1
Loa Loa (eye worm) matrixin family protein 0.0047 0.0032 0.0032
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0043 0.0043
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0002 0.0012
Entamoeba histolytica hypothetical protein 0.0326 0.0347 0.2174
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0078 0.0067 0.0067
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0085 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0326 0.0347 0.0347
Trypanosoma cruzi prefoldin subunit, putative 0.0063 0.005 0.0161
Echinococcus granulosus nervana 2 0.0033 0.0016 0.0016
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0078 0.0067 0.042
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.002 0.0814
Onchocerca volvulus 0.003 0.0013 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0167 0.0168 0.702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0773 0.0854 0.5347
Entamoeba histolytica cysteine protease, putative 0.0326 0.0347 0.2174
Entamoeba histolytica cysteine proteinase, putative 0.0773 0.0854 0.5347
Entamoeba histolytica protein kinase, putative 0.0052 0.0038 0.0237
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0078 0.0067 0.0067
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0043 0.0043
Brugia malayi Hemopexin family protein 0.003 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Plasmodium falciparum serine repeat antigen 2 0.0326 0.0347 0.2174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.143 0.1597 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0252 0.0264 0.1655
Trichomonas vaginalis esterase, putative 0.0036 0.002 0.0122
Brugia malayi cathepsin F-like cysteine proteinase 0.0448 0.0485 0.0486
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Echinococcus multilocularis tyrosine protein kinase csk 0.0078 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0326 0.0347 0.2883
Echinococcus granulosus cathepsin b 0.2775 0.3119 0.3119
Entamoeba histolytica cysteine protease, putative 0.0773 0.0854 0.5347
Echinococcus multilocularis tyrosine protein kinase pr2 0.0078 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0067 0.042
Loa Loa (eye worm) sugar transporter 0.0048 0.0033 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0098 0.0611
Echinococcus granulosus MAM 0.0063 0.005 0.005
Brugia malayi cathepsin Z-like cysteine proteinase 0.0326 0.0347 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0002 0.0012
Schistosoma mansoni protein kinase 0.0078 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0048 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0071
Echinococcus multilocularis tyrosine protein kinase csk 0.0078 0.0067 0.0067
Toxoplasma gondii prefoldin subunit 6, putative 0.0063 0.005 0.0315
Leishmania major cysteine peptidase A (CPA) 0.143 0.1597 1
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Echinococcus multilocularis tyrosine kinase 0.0078 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.0208
Echinococcus multilocularis cathepsin L 0.0773 0.0854 0.0854
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.002 0.002
Schistosoma mansoni glucose transport protein 0.0048 0.0033 0.0033
Plasmodium vivax unspecified product 0.0326 0.0347 0.2174
Loa Loa (eye worm) cytochrome P450 family protein 0.0519 0.0566 0.0567
Echinococcus multilocularis activated cdc42 kinase 1 0.0078 0.0067 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0067 0.042
Toxoplasma gondii AGC kinase 0.0052 0.0038 0.0237
Brugia malayi hypothetical protein 0.0063 0.005 0.005
Loa Loa (eye worm) TK/EPH protein kinase 0.0078 0.0067 0.0067
Schistosoma mansoni calpain (C02 family) 0.0021 0.0002 0.0002
Brugia malayi bone morphogenetic protein type 1 receptor 0.0078 0.0067 0.0067
Brugia malayi calpain family protein 1 0.0055 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0078 0.0067 0.0067
Loa Loa (eye worm) cytochrome P450 0.0167 0.0168 0.0168
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0326 0.0347 0.2174
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0019 0.0118
Leishmania major cytochrome p450-like protein 0.0519 0.0566 0.3547
Leishmania major cathepsin L-like protease 0.143 0.1597 1
Entamoeba histolytica cysteine proteinase, putative 0.143 0.1597 1
Brugia malayi Protein kinase domain containing protein 0.0078 0.0067 0.0067
Echinococcus granulosus cathepsin l1 0.143 0.1597 0.1597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.143 0.1597 1
Echinococcus multilocularis rac serine:threonine kinase 0.0035 0.0019 0.0019
Giardia lamblia Kinase 0.0078 0.0067 0.0557
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0167 0.0168 0.702
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Entamoeba histolytica cysteine proteinase 2 0.0773 0.0854 0.5347
Plasmodium falciparum hexose transporter 0.0048 0.0033 0.0208
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0078 0.0067 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Trichomonas vaginalis TKL family protein kinase 0.0078 0.0067 0.042
Schistosoma mansoni cytochrome P450 0.0167 0.0168 0.0168
Schistosoma mansoni cathepsin F (C01 family) 0.0982 0.109 0.1091
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0085 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0177 0.0179 0.0179
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0029 0.0029
Schistosoma mansoni glucose transport protein 0.0048 0.0033 0.0033
Entamoeba histolytica protein kinase, putative 0.0019 0 0.0003
Brugia malayi Protein kinase domain containing protein 0.0082 0.0071 0.0071

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 6.8 mg kg-1 Compound was tested for the neuroleptic activity as measured by it's antagonism of d-amphetamine induced lethality in grouped mice(GAL) when administered perorally; 5.1-9 ChEMBL. 6110781
ED50 (functional) = 6.8 mg kg-1 Compound was tested for the neuroleptic activity as measured by it's antagonism of d-amphetamine induced lethality in grouped mice(GAL) when administered perorally; 5.1-9 ChEMBL. 6110781
MDD50 (functional) < 50 mg kg-1 Reduction in motor activity in rats following p.o. administration. ChEMBL. 6110781
MED (functional) NA 0 mg kg-1 Inhibition of tetrabenazine induced depression in mice was following p.o. administration; Inactive. ChEMBL. 6110781

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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