Detailed information for compound 619486

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.387 | Formula: C17H16N2OS
  • H donors: 0 H acceptors: 1 LogP: 4.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(=NC(=O)c2ccccc2C)sc2c1cccc2
  • InChi: 1S/C17H16N2OS/c1-3-19-14-10-6-7-11-15(14)21-17(19)18-16(20)13-9-5-4-8-12(13)2/h4-11H,3H2,1-2H3/b18-17+
  • InChiKey: WYVGLHWGYPVIGY-ISLYRVAYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.016 0.0404
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0106 0.0731 0.072
Mycobacterium ulcerans beta-lactamase 0.0037 0.016 0.1321
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1054 0.1043
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0231 0.1954
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.016 0.083
Loa Loa (eye worm) hypothetical protein 0.0058 0.0338 0.0338
Brugia malayi cytochrome P450 0.0028 0.0088 0.0076
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0106 0.0731 1
Leishmania major cytochrome p450-like protein 0.0045 0.0231 0.0966
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0088 0.0425
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1752 0.1742
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0338 0.0326
Onchocerca volvulus 0.0037 0.016 0.0384
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0839 0.0827
Brugia malayi hypothetical protein 0.0086 0.0568 0.0556
Brugia malayi Muscleblind-like protein 0.0293 0.2279 0.227
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0244 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0967 0.0956
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0088 0.0425
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0831 0.082
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1003 0.4371
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0831 0.082
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0474 0.5594
Echinococcus multilocularis muscleblind protein 1 0.0293 0.2279 0.227
Brugia malayi Cytochrome P450 family protein 0.0045 0.0231 0.0219
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.016 0.0404
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0462 0.045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0967 0.0956
Brugia malayi MBOAT family protein 0.0106 0.0731 0.072
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0839 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0839 0.7379
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0839 0.4637
Echinococcus multilocularis zinc finger protein 0.1119 0.9126 0.9125
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.018 0.2329
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.016 0.083
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0088 0.0677
Loa Loa (eye worm) cytochrome P450 family protein 0.0103 0.0711 0.0711
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.016 0.0148
Onchocerca volvulus 0.0037 0.016 0.0384
Mycobacterium leprae conserved hypothetical protein 0.0037 0.016 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0088 0.0425
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0088 0.0425
Brugia malayi Cytochrome P450 family protein 0.0045 0.0231 0.0219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0158 0.0146
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0106 0.0731 0.072
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0462 0.045
Trypanosoma cruzi glycerol uptake protein, putative 0.0106 0.0731 0.3173
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0088 0.0334
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0197 0.0817
Trichomonas vaginalis CMGC family protein kinase 0.005 0.027 0.0703
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.016 0.016
Leishmania major cytochrome p450-like protein 0.0028 0.0088 0.0334
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.027 0.1136
Leishmania major hypothetical protein, conserved 0.0037 0.016 0.0653
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1752 0.1742
Schistosoma mansoni loxhd1 0.002 0.002 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.016 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0088 0.0425
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0462 0.1985
Mycobacterium ulcerans hypothetical protein 0.0037 0.016 0.1321
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0462 0.1985
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0106 0.0731 1
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0106 0.0731 0.0731
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.016 0.1321
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1132 0.6284
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0462 0.045
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0088 0.0677
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0967 0.0967
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2278 1
Loa Loa (eye worm) acetyltransferase 0.0145 0.1054 0.1054
Brugia malayi hypothetical protein 0.002 0.002 0.0008
Loa Loa (eye worm) MBOAT family protein 0.1225 1 1
Entamoeba histolytica hypothetical protein 0.0106 0.0731 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1054 0.1043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0967 0.0956
Echinococcus granulosus zinc finger protein 0.1119 0.9126 0.9125
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0088 0.0677
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0209 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0731 0.1963
Mycobacterium tuberculosis Conserved protein 0.0037 0.016 0.083
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0088 0.0677
Onchocerca volvulus 0.0461 0.3674 1
Brugia malayi beta-lactamase 0.0037 0.016 0.0148
Leishmania major glycerol uptake protein, putative 0.0106 0.0731 0.3173
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0088 0.0425
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.2028
Echinococcus multilocularis muscleblind protein 0.0293 0.2279 0.227
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0462 0.1985
Schistosoma mansoni zinc finger protein 0.1225 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.016 0.0404
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0839 0.7379
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.1225 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.016 0.1321
Trichomonas vaginalis set domain proteins, putative 0.0461 0.3674 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0088 0.0425
Toxoplasma gondii ABC1 family protein 0.0037 0.016 0.179
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 0.5
Echinococcus granulosus mitogen activated protein kinase 0.005 0.027 0.0258
Schistosoma mansoni hypothetical protein 0.0106 0.0731 0.072
Schistosoma mansoni sterol O-acyltransferase 1 0.0106 0.0731 0.072
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.016 0.0148
Echinococcus granulosus o acyltransferase membrane bound domain 0.0106 0.0731 0.072
Leishmania major cytochrome p450-like protein 0.0028 0.0088 0.0334
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0088 0.0677
Brugia malayi MAP kinase sur-1 0.005 0.027 0.0258
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0088 0.0677
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0106 0.0731 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0088 0.0425
Brugia malayi MBOAT family protein 0.0106 0.0731 0.072
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.002 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0474 0.204
Schistosoma mansoni serine/threonine protein kinase 0.005 0.027 0.0258
Loa Loa (eye worm) hypothetical protein 0.0086 0.0568 0.0568
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0088 0.0425
Plasmodium vivax SET domain protein, putative 0.0058 0.0338 0.4532
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.016
Schistosoma mansoni eyes absent homolog 0.0086 0.0568 0.0556
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0474 0.6431
Loa Loa (eye worm) hypothetical protein 0.0229 0.1752 0.1752
Treponema pallidum alginate O-acetylation protein (algI) 0.0106 0.0731 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0244 0.0232
Onchocerca volvulus Huntingtin homolog 0.012 0.0854 0.2281
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0106 0.0731 0.072
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0088 0.0677
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.027 0.0258
Schistosoma mansoni hypothetical protein 0.002 0.002 0.0008
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0088 0.0677
Loa Loa (eye worm) hypothetical protein 0.0106 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0106 0.0731 0.0731
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0088 0.0677
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0088 0.0425
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.002 0.0105
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0197 0.0817
Echinococcus granulosus o acyltransferase membrane bound domain 0.0106 0.0731 0.072
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0088 0.0677
Toxoplasma gondii hypothetical protein 0.0106 0.0731 0.8699
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0106 0.0731 0.072
Leishmania major glycerol uptake protein, putative 0.0106 0.0731 0.3173
Trichomonas vaginalis esterase, putative 0.0037 0.016 0.0404
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1054 0.1043
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.016 0.0653
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.018 0.2329
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0088 0.0425
Onchocerca volvulus Huntingtin homolog 0.012 0.0854 0.2281
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0106 0.0731 0.072
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.6453 0.6449
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Brugia malayi hypothetical protein 0.0048 0.0256 0.0244
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.027 0.3115
Loa Loa (eye worm) hypothetical protein 0.0293 0.2279 0.2279
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0231 0.0966
Loa Loa (eye worm) hypothetical protein 0.012 0.0854 0.0854
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0338 0.3942
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0209 0.2381
Brugia malayi hypothetical protein 0.002 0.002 0.0008
Leishmania major hypothetical protein, conserved 0.0075 0.0474 0.204
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0088 0.0677
Entamoeba histolytica vacuolar protein sorting 26 0.0106 0.0731 1
Trypanosoma brucei glycerol uptake protein, putative 0.0106 0.0731 0.3173
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0106 0.0731 1
Echinococcus multilocularis 0.0028 0.0088 0.0076
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0088 0.0677
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1003 0.4371
Brugia malayi beta-lactamase family protein 0.0037 0.016 0.0148
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0158 0.0146
Leishmania major glycerol uptake protein, putative 0.0106 0.0731 0.3173
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0106 0.0731 0.8699
Brugia malayi Cytochrome P450 family protein 0.0103 0.0711 0.07
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0338 0.0326
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.016 0.083
Plasmodium falciparum LCCL domain-containing protein 0.002 0.002 0.0105
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0106 0.0731 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1021 0.1009
Brugia malayi Cytochrome P450 family protein 0.0028 0.0088 0.0076
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0106 0.0731 0.072
Brugia malayi Pre-SET motif family protein 0.0405 0.3211 0.3203
Echinococcus granulosus RUN 0.002 0.002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.016
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.002 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.005 0.027 0.0703
Loa Loa (eye worm) hypothetical protein 0.0075 0.0474 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0088 0.0425
Loa Loa (eye worm) hypothetical protein 0.0106 0.0731 0.0731
Onchocerca volvulus 0.0037 0.016 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0462 0.1228
Onchocerca volvulus 0.0106 0.0731 0.1946
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.018 0.3723
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0106 0.0731 0.8699
Brugia malayi MBOAT family protein 0.0106 0.0731 0.072
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0197 0.0817
Brugia malayi MBOAT family protein 0.0106 0.0731 0.072
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.0008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.027 0.1136
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0209 0.2737
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0967 0.0956
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.2028
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0088 0.0425
Giardia lamblia Kinase, CMGC MAPK 0.005 0.027 0.5725
Schistosoma mansoni hypothetical protein 0.0033 0.0134 0.0122
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0106 0.0731 0.072
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0209 0.0537
Loa Loa (eye worm) MBOAT family protein 0.0106 0.0731 0.0731
Trichomonas vaginalis transmembrane protein nessy, putative 0.0106 0.0731 0.1963
Trypanosoma cruzi GUP1, putative 0.0106 0.0731 0.3173
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.1225 1 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0462 0.045
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.016 0.0653
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0088 0.0425
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2278 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.016 0.0148
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0209 0.2381
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0088 0.0677
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.2278 1
Echinococcus granulosus sterol O acyltransferase 1 0.0106 0.0731 0.072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0967 0.0956
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0088 0.0425
Schistosoma mansoni lipoxygenase 0.0118 0.0831 0.082
Schistosoma mansoni hypothetical protein 0.0047 0.0244 0.0232
Trypanosoma brucei glycerol uptake protein, putative 0.0106 0.0731 0.3173
Leishmania major glycerol uptake protein, putative 0.0106 0.0731 0.3173
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.016
Loa Loa (eye worm) beta-lactamase 0.0037 0.016 0.016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0338 0.0326
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0474 0.6431
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.027 0.1136
Toxoplasma gondii hypothetical protein 0.0047 0.0247 0.2845
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0338 0.0326
Trichomonas vaginalis CMGC family protein kinase 0.005 0.027 0.0703
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0088 0.0677
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.2278 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0462 0.1985
Loa Loa (eye worm) hypothetical protein 0.0073 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.012 0.0854 0.0854
Onchocerca volvulus 0.0047 0.0244 0.0612
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0088 0.0917
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.016 0.083
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0106 0.0731 0.072
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.3627 0.3619
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0197 0.0817
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.027 0.1136
Loa Loa (eye worm) hypothetical protein 0.0106 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0293 0.2279 0.2279
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0088 0.0334
Echinococcus granulosus muscleblind protein 0.0293 0.2279 0.227
Mycobacterium tuberculosis Conserved protein 0.0037 0.016 0.083
Loa Loa (eye worm) hhat protein 0.0106 0.0731 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0088 0.0425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0967 0.0956
Entamoeba histolytica hypothetical protein, conserved 0.0106 0.0731 1
Schistosoma mansoni polycystin 1-related 0.002 0.002 0.0008
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0462 0.045
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0839 0.0827
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.016 0.0653
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0088 0.0677
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0106 0.0731 0.072
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0008
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.0008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0839 0.3647
Loa Loa (eye worm) doublecortin family protein 0.002 0.002 0.002
Echinococcus granulosus o acyltransferase membrane bound domain 0.0106 0.0731 0.072
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.032 0.0308
Trypanosoma cruzi GUP1, putative 0.0106 0.0731 0.3173
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.2028
Plasmodium vivax hypothetical protein, conserved 0.0037 0.016 0.2058
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0088 0.0677
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.016 0.0148
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0231 0.0231
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.027 0.1136
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0462 0.045
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0088 0.0334
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.2028
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0474 0.204
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0106 0.0731 0.0731
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.3627 0.3619
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.027 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0338 0.0326
Mycobacterium ulcerans lipase LipD 0.0037 0.016 0.1321
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0088 0.0677
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0088 0.0425
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0839 0.0827
Trypanosoma cruzi glycerol uptake protein, putative 0.0106 0.0731 0.3173
Mycobacterium ulcerans hypothetical protein 0.0154 0.1132 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0088 0.0425
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0106 0.0731 0.072
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1794 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.3211 0.3211
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0731 0.1963
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0134 0.0122
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.016 0.083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0839 0.0827
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0134 0.0122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0158 0.0146
Trypanosoma brucei protein kinase, putative 0.005 0.027 0.1136
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0338 0.0326
Brugia malayi Pre-SET motif family protein 0.0058 0.0338 0.0326
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.027 0.027
Brugia malayi Doublecortin family protein 0.002 0.002 0.0008
Leishmania major hypothetical protein, conserved 0.0106 0.0731 0.3173
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0088 0.0677
Schistosoma mansoni hypothetical protein 0.0036 0.0158 0.0146
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1003 0.4371
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0106 0.0731 0.072
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0106 0.0731 0.072
Brugia malayi hypothetical protein 0.0075 0.0474 0.0463
Brugia malayi hypothetical protein 0.0036 0.0158 0.0146
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0462 0.1228
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0338 0.0326
Loa Loa (eye worm) MBOAT family protein 0.0106 0.0731 0.0731
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0474 0.6431
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.016 0.0404
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.016 0.083
Loa Loa (eye worm) hhat protein 0.0106 0.0731 0.0731
Echinococcus granulosus neuropeptide s receptor 0.0455 0.3627 0.3619
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0088 0.0425
Onchocerca volvulus 0.0058 0.0338 0.0871
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.3627 0.3619
Brugia malayi diacylglycerol acyltransferase 0.0106 0.0731 0.072
Trichomonas vaginalis CMGC family protein kinase 0.005 0.027 0.0703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0967 0.0956
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0462 1
Brugia malayi beta-lactamase family protein 0.0037 0.016 0.0148
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0088 0.0334
Echinococcus multilocularis RUN 0.002 0.002 0.0008
Leishmania major glycerol uptake protein, putative 0.0106 0.0731 0.3173
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0088 0.0334
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0231 0.0966
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0731 0.1963
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0231 0.0966
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0474 0.204
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0272 0.1146
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.027 0.1136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0967 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.016 0.0404
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0106 0.0731 0.072
Loa Loa (eye worm) cytochrome P450 0.0028 0.0088 0.0088
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0106 0.0731 0.072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0209 0.0537
Schistosoma mansoni lipoxygenase 0.0082 0.0538 0.0526
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0088 0.0076
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0088 0.0677
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0462 0.045
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0008
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.027 0.0258
Trichomonas vaginalis porcupine, putative 0.0106 0.0731 0.1963
Loa Loa (eye worm) hypothetical protein 0.0086 0.0568 0.0568
Trypanosoma cruzi glycerol uptake protein, putative 0.0106 0.0731 0.3173
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0106 0.0731 0.072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.016 0.083
Brugia malayi Hhat protein 0.0106 0.0731 0.072
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0231 0.0231
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0088 0.0677
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0462 0.6256
Mycobacterium leprae Probable lipase LipE 0.0037 0.016 1
Schistosoma mansoni hypothetical protein 0.0028 0.0088 0.0076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0462 0.1228
Brugia malayi hypothetical protein 0.012 0.0854 0.0842
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0106 0.0731 0.072
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0088 0.0425
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.027 0.1136
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0462 0.045
Brugia malayi hypothetical protein 0.0229 0.1752 0.1742
Echinococcus multilocularis sterol O acyltransferase 1 0.0106 0.0731 0.072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0839 0.7379
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0106 0.0731 0.072
Schistosoma mansoni cytochrome P450 0.0028 0.0088 0.0076
Mycobacterium tuberculosis Conserved protein 0.0037 0.016 0.083
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0462 0.045

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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