Detailed information for compound 619509

Basic information

Technical information
  • TDR Targets ID: 619509
  • Name: methyl 4-[(6,7-dimethoxy-1,2,3,4-tetrahydrois oquinolin-1-yl)methoxy]benzoate
  • MW: 357.4 | Formula: C20H23NO5
  • H donors: 1 H acceptors: 1 LogP: 2.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)OCC1NCCc2c1cc(OC)c(c2)OC
  • InChi: 1S/C20H23NO5/c1-23-18-10-14-8-9-21-17(16(14)11-19(18)24-2)12-26-15-6-4-13(5-7-15)20(22)25-3/h4-7,10-11,17,21H,8-9,12H2,1-3H3
  • InChiKey: CJOVVVGWWPLTDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methoxy]benzoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0064 0.0177 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0206 0.0205
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.108
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0077 0.0077
Echinococcus granulosus neuropeptide s receptor 0.0919 0.3689 0.3689
Echinococcus granulosus tumor protein p63 0.0328 0.1262 0.1261
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0171 0.0619 0.0619
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0315 0.0315
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.006 0.006
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0123 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0071 0.0075
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.0249 0.1121
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0301 0.0301
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0072 0.0587
Brugia malayi nuclear receptor NHR-88 0.0039 0.0077 0.0076
Echinococcus multilocularis sterol O acyltransferase 1 0.0212 0.0784 0.0783
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0043 0.0092 0.0773
Mycobacterium ulcerans L-lysine aminotransferase 0.0064 0.0177 0.0972
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0168 0.0167
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.2456 1 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0064 0.0177 0.0972
Echinococcus granulosus o acyltransferase membrane bound domain 0.0212 0.0784 0.0783
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0569 0.0569
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0076 0.0076
Plasmodium vivax phosphodiesterase gamma, putative 0.0043 0.0092 0.108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0212 0.0784 0.0783
Echinococcus multilocularis muscleblind protein 1 0.0897 0.3598 0.3598
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0324 0.1247 0.1247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Schistosoma mansoni rab6-interacting 0.0039 0.0076 0.0076
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0043 0.0092 0.0092
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0928 0.3726 0.3726
Brugia malayi MBOAT family protein 0.0212 0.0784 0.0783
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.0483
Brugia malayi nuclear hormone receptor 0.0039 0.0077 0.0076
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0063 0.051
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0505 0.0505
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0077 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0092 0.0199
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0212 0.0784 0.8372
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0212 0.0784 0.0784
Brugia malayi diacylglycerol acyltransferase 0.0212 0.0784 0.0783
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0077 0.0076
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0171 0.0619 0.0619
Brugia malayi hypothetical protein 0.0039 0.0076 0.0076
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0168 0.0911
Plasmodium falciparum ornithine aminotransferase 0.0064 0.0177 0.2174
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0043 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0039 0.0076 0.0076
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0071 0.3719
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0058 0.0467
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.033 0.1269 0.712
Onchocerca volvulus 0.0039 0.0077 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0123 0.0381
Echinococcus granulosus RUN 0.0039 0.0076 0.0076
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0063 0.051
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0077 0.0076
Entamoeba histolytica hypothetical protein 0.0071 0.0206 0.2546
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.0483
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0064 0.0177 0.0963
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0112 0.0374 0.2091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0026 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0077 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0058 0.0467
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0773
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0063 0.0063
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.108
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0071 0.0367
Mycobacterium ulcerans beta-lactamase 0.0035 0.0058 0.0295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0077 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0077 0.0076
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0007
Brugia malayi MBOAT family protein 0.0212 0.0784 0.0783
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0071 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0077 0.0076
Trypanosoma cruzi glycerol uptake protein, putative 0.0212 0.0784 0.7032
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0063 0.0063
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0059 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0116 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0206 0.0205
Giardia lamblia hypothetical protein 0.0043 0.0092 0.4835
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0569 0.0569
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0123 0.0123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0229 0.0856 0.0856
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0914 0.5034
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.006 0.001
Trichomonas vaginalis conserved hypothetical protein 0.033 0.1269 0.712
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0058 0.0058
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0058 0.0058
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0449 0.1758 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0043 0.0092 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0077 0.0076
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.006 0.001
Leishmania major hypothetical protein, conserved 0.0043 0.0092 0.0773
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0043 0.0092 0.0199
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0112
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0042 0.0041
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0077 0.0076
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0043 0.0092 0.0773
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0092 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.0935 0.5155
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0071 0.1325
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.108
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0077 0.0076
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0462 0.181 0.181
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0058 0.0058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0042 0.0041
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0071 0.0814
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0212 0.0784 0.0784
Brugia malayi Pre-SET motif family protein 0.0032 0.0048 0.0047
Mycobacterium tuberculosis Conserved protein 0.0035 0.0058 0.0286
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0076 0.0076
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Echinococcus multilocularis muscleblind protein 0.0897 0.3598 0.3598
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0092 0.0199
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0212 0.0784 0.0783
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0077 0.0077
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0077 0.0076
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0212 0.0784 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.0856 0.0856
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0064 0.0177 0.0963
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.006 0.0667
Echinococcus granulosus zinc finger protein 0.2245 0.9131 0.9131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.0856 0.0856
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0048 0.0047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0095 0.0938
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.006 0.006
Mycobacterium ulcerans acetylornithine aminotransferase 0.0064 0.0177 0.0972
Echinococcus multilocularis RUN 0.0039 0.0076 0.0076
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0007 0.0007
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0212 0.0784 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0063 0.0063
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.2456 1 1
Echinococcus multilocularis tumor protein p63 0.0328 0.1262 0.1261
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0064 0.0177 0.0963
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Echinococcus granulosus zinc finger protein 0.0028 0.0028 0.0028
Echinococcus granulosus sterol O acyltransferase 1 0.0212 0.0784 0.0783
Echinococcus multilocularis GPCR, family 2 0.0031 0.0042 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0048 0.0047
Onchocerca volvulus 0.0039 0.0076 0.0334
Brugia malayi CXXC zinc finger family protein 0.0087 0.027 0.027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0155 0.0552 0.2901
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0077 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0077 0.0076
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0212 0.0784 0.0783
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0076 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0168 0.092
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0043 0.0092 0.0092
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0071 0.1397
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0569 0.0569
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0058 0.0286
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.027 0.027
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Leishmania major glycerol uptake protein, putative 0.0212 0.0784 0.7032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0832 0.4705
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0773
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0008 0.0007
Brugia malayi Muscleblind-like protein 0.0897 0.3598 0.3598
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Schistosoma mansoni lipoxygenase 0.0101 0.0328 0.0328
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0168 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0077 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.0856 0.0856
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Brugia malayi MAP kinase sur-1 0.0051 0.0123 0.0123
Echinococcus granulosus Aminotransferase class III 0.0064 0.0177 0.0176
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Entamoeba histolytica hypothetical protein 0.0071 0.0206 0.2546
Schistosoma mansoni hypothetical protein 0.0817 0.3271 0.3271
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0123 0.0123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0155 0.0552 0.2901
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.006 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0043 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0897 0.3598 0.3598
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0077 0.0076
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0076 0.0076
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0095 0.0938
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0043 0.0092 0.4835
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0077 0.0076
Leishmania major hypothetical protein, conserved 0.0043 0.0092 0.0773
Plasmodium vivax ornithine aminotransferase, putative 0.0064 0.0177 0.2174
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0123 0.0123
Schistosoma mansoni zinc finger protein 0.0028 0.0028 0.0028
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0123 0.0381
Schistosoma mansoni sterol O-acyltransferase 1 0.0212 0.0784 0.0783
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0042 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0077 0.0077
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0123 0.1239
Brugia malayi MH2 domain containing protein 0.0234 0.0874 0.0873
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0569 0.0569
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0058 0.0295
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0247 0.0247
Brugia malayi Bromodomain containing protein 0.0082 0.0251 0.025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0077 0.0076
Leishmania major hypothetical protein, conserved 0.0212 0.0784 0.7032
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.0199
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0773
Toxoplasma gondii hypothetical protein 0.0248 0.0935 1
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0064 0.0177 0.0972
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0071 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0077 0.0076
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0064 0.0177 0.0963
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0063 0.0063
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0043 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0374 0.1858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0116 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0077 0.0076
Schistosoma mansoni cpg binding protein 0.0087 0.027 0.027
Plasmodium falciparum phosphodiesterase delta, putative 0.0043 0.0092 0.108
Onchocerca volvulus 0.0094 0.0301 0.2929
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0292 0.1112 1
Echinococcus multilocularis ornithine aminotransferase 0.0064 0.0177 0.0176
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.018 0.0652 0.3495
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0229 0.0856 0.0856
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.001
Mycobacterium ulcerans hypothetical protein 0.0449 0.1758 1
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0029 0.0029
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0043 0.0092 0.0092
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0247 0.0247
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0874 0.0874
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.0199
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0064 0.0177 0.0176
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0189 0.0189
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0292 0.1112 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0058 0.0058
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0043 0.0092 0.0092
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0241 0.0906 0.0906
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Trypanosoma brucei glucosidase, putative 0.0035 0.006 0.0483
Loa Loa (eye worm) hypothetical protein 0.0069 0.0199 0.0199
Mycobacterium ulcerans putative regulatory protein 0.0112 0.0374 0.2098
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0008 0.0015
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0292 0.1112 0.6198
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.018 0.0652 0.3495
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0212 0.0784 0.0784
Onchocerca volvulus 0.0035 0.0058 0.0125
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0368 0.1424 0.1424
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Loa Loa (eye worm) beta-lactamase 0.0035 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0212 0.0784 0.0783
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0292 0.1112 0.1112
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0292 0.1112 0.1112
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.0006
Onchocerca volvulus 0.0087 0.027 0.2568
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0043 0.0092 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0094 0.0301 0.0301
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.006 0.0483
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0168 0.0167
Brugia malayi PHD-finger family protein 0.0033 0.0049 0.0049
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0449 0.1758 1
Onchocerca volvulus 0.0092 0.0293 0.2837
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0077 0.0076
Onchocerca volvulus 0.0035 0.0058 0.0125
Brugia malayi beta-lactamase family protein 0.0035 0.0058 0.0058
Schistosoma mansoni zinc finger protein 0.2456 1 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.3598 0.3598
Loa Loa (eye worm) hypothetical protein 0.0212 0.0784 0.0784
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0077 0.0076
Onchocerca volvulus Huntingtin homolog 0.012 0.0407 0.4148
Brugia malayi ecdysteroid receptor 0.0039 0.0077 0.0076
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0212 0.0784 0.0783
Echinococcus granulosus muscleblind protein 0.0897 0.3598 0.3598
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0063 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Leishmania major hypothetical protein, conserved 0.0035 0.0058 0.0467
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0077 0.0077
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0063 0.0063
Trypanosoma cruzi glycerol uptake protein, putative 0.0212 0.0784 0.7032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.0199
Schistosoma mansoni ap endonuclease 0.0038 0.0071 0.0071
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0063 0.0028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0076 0.0076
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0168 0.0167
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0368 0.1424 0.1424
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0449 0.1758 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0077 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0077 0.0076
Loa Loa (eye worm) hhat protein 0.0212 0.0784 0.0784
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.0006
Schistosoma mansoni cpg binding protein 0.0093 0.0298 0.0298
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0076
Echinococcus granulosus cpg binding protein 0.0093 0.0298 0.0298
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0058 0.0286
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0072 0.0587
Onchocerca volvulus 0.0212 0.0784 0.8497
Toxoplasma gondii hypothetical protein 0.0112 0.0374 0.395
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0292 0.1112 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.005 0.0121 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0026 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0072 0.0362
Mycobacterium tuberculosis Conserved protein 0.0035 0.0058 0.0286
Loa Loa (eye worm) hypothetical protein 0.012 0.0407 0.0407
Entamoeba histolytica hypothetical protein 0.0071 0.0206 0.2546
Onchocerca volvulus Huntingtin homolog 0.012 0.0407 0.4148
Trichomonas vaginalis porcupine, putative 0.0212 0.0784 0.4268
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0773
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0123 0.1053
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0123 0.1053
Brugia malayi hypothetical protein 0.0462 0.181 0.181
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0064 0.0177 0.0963
Loa Loa (eye worm) hypothetical protein 0.0241 0.0906 0.0906
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0077 0.0076
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0008 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0058 0.0286
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.006 0.006
Brugia malayi hypothetical protein 0.0039 0.0076 0.0076
Mycobacterium ulcerans lipase LipD 0.0035 0.0058 0.0295
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0036 0.0035
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0212 0.0784 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.0784 0.4268
Trypanosoma brucei glycerol uptake protein, putative 0.0212 0.0784 0.7032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0077 0.0076
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0063 0.051
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Brugia malayi Hhat protein 0.0212 0.0784 0.0783
Toxoplasma gondii exonuclease III APE 0.0038 0.0071 0.0677
Toxoplasma gondii histone lysine methyltransferase SET1 0.0171 0.0616 0.6562
Echinococcus multilocularis neuropeptide s receptor 0.0919 0.3689 0.3689
Schistosoma mansoni alpha glucosidase 0.0035 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.0784 0.4268
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0449 0.1758 1
Echinococcus multilocularis ornithine aminotransferase 0.0064 0.0177 0.0176
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0123 0.1053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0077 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.0784 0.4268
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.108
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0043 0.0092 0.108
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0505 0.0505
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0072 0.0587
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0123 0.0381
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0212 0.0784 0.0784
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0292 0.1112 0.6198
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0071 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0212 0.0784 0.0784
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0077 0.0077
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0076 0.0879
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0043 0.0092 0.0199
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Trypanosoma cruzi glycerol uptake protein, putative 0.0212 0.0784 0.7032
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Schistosoma mansoni cpg binding protein 0.0093 0.0298 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0048 0.0047
Trypanosoma cruzi GUP1, putative 0.0212 0.0784 0.7032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.012 0.0407 0.0407
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0077 0.0076
Brugia malayi beta-lactamase 0.0035 0.0058 0.0058
Schistosoma mansoni rab6-interacting 0.0039 0.0076 0.0076
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0064 0.0177 0.0963
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0212 0.0784 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0077 0.0076
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0155 0.0552 0.2901
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.048 0.0479
Schistosoma mansoni alpha-glucosidase 0.0137 0.0478 0.0478
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0077 0.0076
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0043 0.0092 0.0199
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0043 0.0092 0.0773
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0077 0.0076
Schistosoma mansoni ap endonuclease 0.0038 0.0071 0.0071
Plasmodium vivax SET domain protein, putative 0.0032 0.0048 0.0505
Schistosoma mansoni loxhd1 0.0039 0.0076 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0042 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0123 0.0123
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.181 0.181
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0123 0.0123
Schistosoma mansoni polycystin 1-related 0.0039 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0058 0.0286
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0247 0.0247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Echinococcus granulosus o acyltransferase membrane bound domain 0.0212 0.0784 0.0783
Trypanosoma brucei protein kinase, putative 0.0051 0.0123 0.1053
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.0249 0.1121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0185 0.0673 0.0673
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0773
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0123 0.1053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0212 0.0784 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.006 0.0667
Onchocerca volvulus 0.0048 0.0112 0.0743
Brugia malayi Bromodomain containing protein 0.0041 0.0083 0.0082
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.108
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0064 0.0177 0.0972
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0043 0.0092 0.0092
Echinococcus granulosus o acyltransferase membrane bound domain 0.0212 0.0784 0.0783
Leishmania major glycerol uptake protein, putative 0.0212 0.0784 0.7032
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0041
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0212 0.0784 0.0783
Schistosoma mansoni coup transcription factor 0.0039 0.0077 0.0076
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0063 0.0063
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0125 0.0125
Mycobacterium ulcerans putative regulatory protein 0.0112 0.0374 0.2098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0042 0.0041
Brugia malayi Pre-SET motif family protein 0.0214 0.0794 0.0793
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0077 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0058 0.0467
Echinococcus granulosus dnaJ subfamily B 0.0817 0.3271 0.3271
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0374 0.2091
Loa Loa (eye worm) PDE1B protein 0.0043 0.0092 0.0092
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.181 0.181
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0212 0.0784 0.8372
Entamoeba histolytica hypothetical protein, conserved 0.0212 0.0784 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.015 0.0531 0.2994
Echinococcus multilocularis neuropeptide receptor A26 0.0919 0.3689 0.3689
Mycobacterium tuberculosis Probable aminotransferase 0.0449 0.1758 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0043 0.0092 0.0092
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0292 0.1112 0.1112
Mycobacterium tuberculosis Conserved protein 0.0035 0.0058 0.0286
Schistosoma mansoni bromodomain containing protein 0.007 0.0204 0.0203
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0043 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0092
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0071 0.0075
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0076 0.0076
Onchocerca volvulus 0.0035 0.0058 0.0125
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0212 0.0784 0.0783
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0189 0.0188
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0123 0.1053
Giardia lamblia Hypothetical protein 0.0043 0.0092 0.4835
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0098 0.0315 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0168 0.092
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0292 0.1112 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0241 0.0906 0.0906
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0212 0.0784 0.0783
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0071 0.0808
Entamoeba histolytica vacuolar protein sorting 26 0.0212 0.0784 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0071 0.0071
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0043 0.0092 0.108
Brugia malayi hypothetical protein 0.012 0.0407 0.0407
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0112 0.0112
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Schistosoma mansoni hypothetical protein 0.0067 0.0189 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.0935 0.5155
Echinococcus multilocularis cpg binding protein 0.0093 0.0298 0.0298
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0043 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0041
Brugia malayi beta-lactamase family protein 0.0035 0.0058 0.0058
Leishmania major glycerol uptake protein, putative 0.0212 0.0784 0.7032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0008 0.0007
Loa Loa (eye worm) MBOAT family protein 0.0212 0.0784 0.0784
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0071 0.0071
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Loa Loa (eye worm) MBOAT family protein 0.0212 0.0784 0.0784
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0368 0.1424 0.1424
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0077 0.0076
Toxoplasma gondii hypothetical protein 0.0212 0.0784 0.8372
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.0199
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0077 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0063
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0043 0.0092 0.0092
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1605 0.6504 0.6503
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0058 0.0286
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0315 0.0315
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0071 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.0856 0.0856
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0315 0.0315
Loa Loa (eye worm) MBOAT family protein 0.2456 1 1
Trichomonas vaginalis transmembrane protein nessy, putative 0.0212 0.0784 0.4268
Loa Loa (eye worm) hypothetical protein 0.0049 0.0116 0.0116
Trypanosoma brucei glycerol uptake protein, putative 0.0212 0.0784 0.7032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0077 0.0076
Onchocerca volvulus 0.0081 0.0247 0.2306
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0212 0.0784 0.0783
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0077 0.0076
Schistosoma mansoni hypothetical protein 0.0071 0.0206 0.0205
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0043 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.0935 0.5155
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0043 0.0092 0.0092
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0095 0.112
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0773
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0077 0.0077
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0095 0.0217
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0043 0.0092 0.0773
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0292 0.1112 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0206 0.0205
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0043 0.0092 0.0773
Loa Loa (eye worm) hypothetical protein 0.0213 0.0787 0.0787
Onchocerca volvulus 0.0243 0.0914 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0123 0.1053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0058 0.0645
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0212 0.0784 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0212 0.0784 0.0783
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0168 0.092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0116 0.0116
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Brugia malayi follicle stimulating hormone receptor 0.0928 0.3726 0.3726
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0071 0.0808
Brugia malayi steroid hormone receptor 0.0039 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0067 0.0189 0.0189
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0212 0.0784 0.0783
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0043 0.0092 0.0092
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0063 0.0706
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0071 0.0582
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0077 0.0076
Trypanosoma cruzi GUP1, putative 0.0212 0.0784 0.7032
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0058 0.0295
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.015 0.0531 0.2987
Echinococcus multilocularis zinc finger protein 0.2245 0.9131 0.9131
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0092
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0569 0.0569
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.006 0.001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Brugia malayi MBOAT family protein 0.0212 0.0784 0.0783
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0095 0.0217
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0026 0.0025
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.033 0.1269 0.712
Entamoeba histolytica hypothetical protein 0.0071 0.0206 0.2546
Loa Loa (eye worm) acetyltransferase 0.0144 0.0505 0.0505
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0043 0.0092 0.0092
Mycobacterium leprae Probable lipase LipE 0.0035 0.0058 0.0286
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0043 0.0092 0.0092
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.001
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0123 0.0123
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0212 0.0784 0.0783
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0008 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0071 0.0582
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0212 0.0784 0.0783
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0168 0.1457
Plasmodium falciparum GAF domain-related protein, putative 0.0112 0.0374 0.4719
Treponema pallidum alginate O-acetylation protein (algI) 0.0212 0.0784 1
Leishmania major hypothetical protein, conserved 0.0038 0.0072 0.0587
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0071 0.0582
Echinococcus multilocularis dnaJ subfamily B 0.0817 0.3271 0.3271
Leishmania major glycerol uptake protein, putative 0.0212 0.0784 0.7032
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0058 0.0286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0058 0.0286
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0212 0.0784 0.0783
Echinococcus multilocularis zinc finger protein 0.0028 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0081 0.0247 0.0247
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.006 0.0558
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0123 0.1053
Brugia malayi MBOAT family protein 0.0212 0.0784 0.0783
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0077 0.0339
Brugia malayi Cytochrome P450 family protein 0.0051 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0029 0.0029
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0071 0.0808
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0212 0.0784 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0063 0.0063
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Brugia malayi Doublecortin family protein 0.0039 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0063 0.0028
Plasmodium falciparum phosphodiesterase gamma, putative 0.0043 0.0092 0.108
Echinococcus granulosus ornithine aminotransferase 0.0064 0.0177 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0077 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0092 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0077 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0041
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0043 0.0092 0.0773
Brugia malayi hypothetical protein 0.0071 0.0206 0.0205
Mycobacterium ulcerans hypothetical protein 0.0035 0.0058 0.0295
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0043 0.0092 0.0092
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0077 0.0076
Toxoplasma gondii GAF domain-containing protein 0.0112 0.0374 0.395
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0374 0.4719
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0095 0.0095
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0008 0.0015
Schistosoma mansoni alpha-glucosidase 0.0137 0.0478 0.0478
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0064 0.0177 0.0963
Echinococcus multilocularis Aminotransferase class III 0.0064 0.0177 0.0176
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0168 0.1721
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0077 0.0076
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0064 0.0177 0.0176
Schistosoma mansoni survival motor neuron protein 0.0094 0.0301 0.0301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0077 0.0076
Leishmania major cAMP-specific phosphodiesterase, putative 0.0043 0.0092 0.0773
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0292 0.1112 0.6198
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0048 0.0423
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0077 0.0339
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0116 0.0116
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0071 0.0358
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0043 0.0092 0.0773
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0064 0.0177 0.182
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0063 0.051
Toxoplasma gondii ABC1 family protein 0.0035 0.0058 0.054
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.018 0.0652 0.5843
Toxoplasma gondii hypothetical protein 0.0112 0.0374 0.395
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0123 0.0381
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0043 0.0092 0.0092
Echinococcus granulosus neuropeptide receptor A26 0.0919 0.3689 0.3689
Schistosoma mansoni lipoxygenase 0.0171 0.0619 0.0619
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0064 0.0177 0.0972
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0874 0.0874
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0292 0.1112 0.6198
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0212 0.0784 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0071 0.0814
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0794 0.0794
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.0856 0.0856
Onchocerca volvulus 0.0039 0.0076 0.0334
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0042 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0092 0.0904
Leishmania major glycerol uptake protein, putative 0.0212 0.0784 0.7032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0076 0.0076
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.033 0.1269 0.712
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0212 0.0784 0.0783
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0212 0.0784 0.0783
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0058 0.0058
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0077 0.0339
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0029 0.0029
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0076 0.0879
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0077 0.0076
Echinococcus granulosus GPCR family 2 0.0031 0.0042 0.0041
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0058 0.0286
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0064 0.0177 1
Loa Loa (eye worm) hhat protein 0.0212 0.0784 0.0784
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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