Detailed information for compound 628911

Basic information

Technical information
  • TDR Targets ID: 628911
  • Name: N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4 -methoxy-1,3-benzothiazol-2-amine
  • MW: 342.348 | Formula: C16H11FN4O2S
  • H donors: 1 H acceptors: 3 LogP: 4.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1nc(s2)Nc1nnc(o1)c1ccc(cc1)F
  • InChi: 1S/C16H11FN4O2S/c1-22-11-3-2-4-12-13(11)18-16(24-12)19-15-21-20-14(23-15)9-5-7-10(17)8-6-9/h2-8H,1H3,(H,18,19,21)
  • InChiKey: TUNSTYGNRZSNSX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-(4-methoxy-1,3-benzothiazol-2-yl)amine
  • MLS000529876
  • UNM000003519801
  • ZINC04137645
  • SMR000126937

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens dual specificity phosphatase 3 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica dual specificity protein phosphatase, putative Get druggable targets OG5_134995 All targets in OG5_134995
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis pps1 dual specificty phosphatase, putative Get druggable targets OG5_134995 All targets in OG5_134995
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Trypanosoma brucei kinetoplastid-specific dual specificity phosphatase, putative dual specificity phosphatase 3 185 aa 182 aa 25.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0023 0.0093 0.0162
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0057 0.0507 0.0507
Trypanosoma brucei trypanothione reductase 0.0048 0.0392 0.0712
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0783 0.0783
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.001 0.001
Trichomonas vaginalis heat shock protein, putative 0.0031 0.019 0.0222
Brugia malayi metallopeptidase family M24 containing protein 0.0057 0.0507 0.0793
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1289 0.4001
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.019 0.0331
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0461 0.5443 0.6502
Loa Loa (eye worm) glutathione reductase 0.0048 0.0392 0.0617
Mycobacterium ulcerans hypothetical protein 0.0043 0.034 0.1534
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0261 0.0261
Echinococcus multilocularis endoplasmin 0.0031 0.019 0.019
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1919 0.352
Mycobacterium leprae conserved hypothetical protein 0.0043 0.034 0.0866
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0057 0.0507 0.0503
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0057 0.0507 0.0925
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0535
Trichomonas vaginalis heat shock protein, putative 0.0031 0.019 0.0222
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.019 0.3618
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0057 0.0507 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.036 0.036
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.034 0.1031
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.114 0.3536
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0057 0.0507 0.0925
Onchocerca volvulus 0.0033 0.0206 0.0318
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0093 0.0139
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Schistosoma mansoni heat shock protein 0.0039 0.0288 0.0283
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.034 0.1534
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0021 0.0033
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Echinococcus multilocularis methionine aminopeptidase, type I 0.0057 0.0507 0.0507
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5849 0.5849
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0313
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0023 0.0023
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0261 0.0306
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0057 0.0507 0.0507
Mycobacterium tuberculosis Conserved protein 0.0043 0.034 0.1031
Echinococcus granulosus heat shock protein 90 0.0031 0.019 0.019
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.001 0.001
Toxoplasma gondii methionine aminopeptidase 0.0057 0.0507 0.0925
Trypanosoma cruzi aminopeptidase P1, putative 0.0057 0.0507 0.0925
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0188
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0057 0.0507 0.0925
Loa Loa (eye worm) hypothetical protein 0.006 0.0544 0.0857
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0093 0.0162
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0461 0.5443 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0392 0.0712
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0288 0.0521
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.034 0.0401
Schistosoma mansoni cpg binding protein 0.0039 0.0279 0.0275
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.036 0.0356
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0057 0.0507 0.0503
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0057 0.0507 0.0503
Plasmodium falciparum thioredoxin reductase 0.0017 0.001 0.001
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0261 0.0256
Mycobacterium ulcerans aminopeptidase 0.0057 0.0507 0.2316
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.0546
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.001 0.0006
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.001 0.0007
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Chlamydia trachomatis methionine aminopeptidase 0.0057 0.0507 1
Treponema pallidum aminopeptidase P 0.0057 0.0507 0.1209
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0507 0.0601
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0104 0.0104
Schistosoma mansoni lamin 0.0033 0.0206 0.0202
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0461 0.5443 0.6502
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0004 0.0004
Toxoplasma gondii ABC1 family protein 0.0043 0.034 0.0616
Brugia malayi Thioredoxin reductase 0.0048 0.0392 0.061
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0057 0.0507 0.0925
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0242 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0324 0.0382
Brugia malayi TAR-binding protein 0.0063 0.0573 0.0895
Schistosoma mansoni intermediate filament proteins 0.0033 0.0206 0.0202
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0288 0.0453
Echinococcus granulosus heat shock protein 90 0.0039 0.0288 0.0288
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0324 0.0588
Echinococcus granulosus cpg binding protein 0.0039 0.0279 0.0279
Echinococcus granulosus heat shock protein 0.0039 0.0288 0.0288
Echinococcus multilocularis methionyl aminopeptidase 2 0.0461 0.5443 0.5443
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0043 0.034 0.0616
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.019 0.0341
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Echinococcus granulosus lamin 0.0033 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.004 0.03 0.0472
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0261 0.0261
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0057 0.0507 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0568
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0057 0.0507 0.0925
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0057 0.0507 0.0925
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0573 0.0902
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Plasmodium vivax peptidase, putative 0.0057 0.0507 0.0925
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0261 0.0471
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0057 0.0507 0.0503
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4268 0.784
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1919 0.352
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0093 0.0259
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.034 0.1031
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0783 0.1227
Loa Loa (eye worm) STAT protein 0.0191 0.2139 0.3368
Entamoeba histolytica hypothetical protein 0.0042 0.0324 0.0382
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0119 0.0211
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.001 0.001
Toxoplasma gondii thioredoxin reductase 0.0048 0.0392 0.0712
Mycobacterium tuberculosis Conserved protein 0.0043 0.034 0.1031
Mycobacterium ulcerans beta-lactamase 0.0043 0.034 0.1534
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0435 0.0792
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.034 0.1031
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0093 0.0093
Brugia malayi Bromodomain containing protein 0.0076 0.0737 0.1155
Echinococcus multilocularis heat shock protein 0.0039 0.0288 0.0288
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0261 0.0471
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.034 0.1031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0009
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0288 0.0521
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0093 0.0139
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0261 0.0261
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0093 0.0385
Schistosoma mansoni lamin 0.0033 0.0206 0.0202
Giardia lamblia Grp94/Hsp90 0.0031 0.019 0.0331
Plasmodium falciparum glutathione reductase 0.0048 0.0392 0.0712
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0288 0.0339
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0119 0.0211
Echinococcus granulosus xaa pro aminopeptidase 0.0057 0.0507 0.0507
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0057 0.0507 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0324 0.0382
Brugia malayi intermediate filament protein 0.0033 0.0206 0.0318
Treponema pallidum methionine aminopeptidase (map) 0.0057 0.0507 0.1209
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0392 0.0712
Schistosoma mansoni cpg binding protein 0.0035 0.0232 0.0228
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.036 0.056
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0102 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0435 0.0792
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0093 0.0163
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0261 0.0404
Toxoplasma gondii peptidase D, putative 0.0057 0.0507 0.0925
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0023 0.0018
Schistosoma mansoni zinc finger protein 0.0021 0.0068 0.0064
Echinococcus granulosus FACT complex subunit SPT16 0.0057 0.0507 0.0507
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0206 0.0318
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0288 0.0511
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0104 0.0104
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0461 0.5443 0.5441
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0573 0.0895
Plasmodium falciparum thioredoxin reductase 0.0048 0.0392 0.0712
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0435 0.0792
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Loa Loa (eye worm) hypothetical protein 0.0041 0.0311 0.049
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0392 0.0617
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.114 0.5502
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0104 0.01
Toxoplasma gondii transcriptional elongation factor FACT140 0.0057 0.0507 0.0925
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0288 0.0521
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0288 0.0521
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0057 0.0507 0.0799
Brugia malayi RNA binding protein 0.0063 0.0573 0.0895
Echinococcus multilocularis heat shock protein 90 0.0031 0.019 0.019
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0057 0.0507 0.0925
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0093 0.0106
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0261 0.0261
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Brugia malayi PHD-finger family protein 0.0027 0.0133 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0461 0.5443 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0324 0.0588
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0057 0.0507 0.0793
Loa Loa (eye worm) methionine aminopeptidase type I 0.0057 0.0507 0.0799
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.001 0.001
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0261 0.0306
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0057 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0036
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0057 0.0507 0.2316
Brugia malayi Bromodomain containing protein 0.0038 0.027 0.0419
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0057 0.0507 0.0503
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0057 0.0507 0.1556
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3205 1
Trypanosoma brucei methionine aminopeptidase, putative 0.0057 0.0507 0.0925
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0372 0.0372
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0093 0.0163
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0057 0.0507 0.1556
Brugia malayi glutathione reductase 0.0048 0.0392 0.061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.036 0.0356
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0057 0.0507 0.1838
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Loa Loa (eye worm) RNA binding protein 0.0063 0.0573 0.0902
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0553 0.0553
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.034 0.1031
Echinococcus multilocularis transcription factor btf3 0.0042 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0057 0.0507 0.0799
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0288 0.0521
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0093 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Giardia lamblia DINP protein human, muc B family 0.0023 0.0093 0.0152
Brugia malayi beta-lactamase 0.0043 0.034 0.0528
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0057 0.0507 0.1556
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.034 0.0616
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.019 0.0563
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.064 0.1168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0036
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0324 0.0588
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Schistosoma mansoni lozenge 0.0067 0.0628 0.0624
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0261 0.0461
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0041 0.0041
Echinococcus multilocularis lamin 0.0033 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0568
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0119 0.0211
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.001 0.001
Entamoeba histolytica dual specificity protein phosphatase, putative 0.07 0.837 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4268 0.784
Brugia malayi beta-lactamase family protein 0.0043 0.034 0.0528
Echinococcus multilocularis geminin 0.0171 0.1901 0.1901
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.034 0.034
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.2157 0.672
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.034 0.0401
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.034 0.1534
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0057 0.0507 0.0925
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1289 0.4001
Leishmania major basic transcription factor 3a, putative 0.0042 0.0324 0.0588
Onchocerca volvulus 0.0033 0.0206 0.0318
Schistosoma mansoni hypothetical protein 0.0494 0.5849 0.5847
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0093 0.0106
Echinococcus multilocularis xaa Pro dipeptidase 0.0057 0.0507 0.0507
Schistosoma mansoni DNA polymerase eta 0.0023 0.0093 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0119 0.0211
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0261 0.0261
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0119 0.0211
Schistosoma mansoni hypothetical protein 0.0041 0.0311 0.0307
Leishmania major hypothetical protein, conserved 0.0025 0.0119 0.0211
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0288 0.0521
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0119 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0568
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0057 0.0507 0.0925
Echinococcus granulosus Proliferation associated protein 2G4 0.0057 0.0507 0.0507
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0057 0.0507 0.0925
Trichomonas vaginalis esterase, putative 0.0043 0.034 0.0401
Leishmania major DNA polymerase kappa, putative 0.0023 0.0093 0.0162
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.114 0.3536
Echinococcus granulosus GPCR family 2 0.0019 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.034 0.0616
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0324 0.0382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Brugia malayi hypothetical protein 0.0535 0.635 1
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0261 0.0261
Brugia malayi Methionine aminopeptidase protein type I 0.0057 0.0507 0.0793
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0568
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0023 0.0018
Onchocerca volvulus Dipeptidase C homolog 0.0057 0.0507 0.0793
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.034 0.0335
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0573 0.0902
Echinococcus multilocularis xaa pro aminopeptidase 0.0057 0.0507 0.0507
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1917 0.5967
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1919 0.352
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0057 0.0507 0.0925
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Echinococcus granulosus geminin 0.0171 0.1901 0.1901
Giardia lamblia Xaa-Pro dipeptidase 0.0057 0.0507 0.0915
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.001
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0091 0.0159
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0057 0.0507 0.1838
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0041 0.0041
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0206 0.0325
Echinococcus granulosus methionyl aminopeptidase 2 0.0461 0.5443 0.5443
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0041 0.0057
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0057 0.0507 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0093 0.0163
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0093 0.0106
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0261 0.0471
Echinococcus granulosus dna polymerase eta 0.0023 0.0093 0.0093
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0041 0.0041
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0057 0.0507 0.1838
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0535
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.034 0.0401
Brugia malayi initiation factor 2-associated protein. 0.0461 0.5443 0.8572
Mycobacterium tuberculosis Probable reductase 0.0109 0.114 0.3536
Echinococcus granulosus intermediate filament protein 0.0033 0.0206 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Plasmodium falciparum endoplasmin, putative 0.0024 0.0102 0.018
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Brugia malayi STAT protein, DNA binding domain containing protein 0.0191 0.2139 0.3364
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.001 0.0011
Plasmodium falciparum methionine aminopeptidase 2 0.0461 0.5443 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.036 0.036
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Schistosoma mansoni endoplasmin 0.0039 0.0288 0.0283
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Echinococcus multilocularis Protein lozenge 0.0067 0.0628 0.0628
Brugia malayi hypothetical protein 0.0025 0.0119 0.0181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.041
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0057 0.0507 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0057 0.0507 0.0507
Brugia malayi beta-NAC-like protein 0.0042 0.0324 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0093 0.0088
Echinococcus granulosus endoplasmin 0.0031 0.019 0.019
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.07 0.837 1
Leishmania major transcription factor-like protein 0.0057 0.0507 0.0925
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0535 0.635 1
Toxoplasma gondii creatinase domain-containing protein 0.0057 0.0507 0.0925
Echinococcus multilocularis musashi 0.0033 0.0206 0.0206
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Schistosoma mansoni transcription factor btf3 0.0042 0.0324 0.032
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0057 0.0507 0.0925
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1917 0.8878
Onchocerca volvulus 0.0035 0.0232 0.0358
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0093 0.0162
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0206 0.0325
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.4268 0.784
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0461 0.5443 1
Echinococcus granulosus xaa Pro dipeptidase 0.0057 0.0507 0.0507
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0014 0.0014
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.034 0.1031
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0544 0.085
Loa Loa (eye worm) initiation factor 2-associated protein 0.0461 0.5443 0.8573
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.114 0.3536
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.019 0.0341
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.034 0.034
Echinococcus granulosus tar DNA binding protein 0.0063 0.0573 0.0573
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0171 0.1901 0.1897
Brugia malayi Endoplasmin precursor 0.0039 0.0288 0.0447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.034 0.0535
Echinococcus multilocularis lamin dm0 0.0033 0.0206 0.0206
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0057 0.009
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0288 0.0521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.036 0.0356
Onchocerca volvulus 0.0535 0.635 1
Echinococcus granulosus lamin dm0 0.0033 0.0206 0.0206
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0783 0.1431
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0093 0.0162
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0102 0.0117
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0057 0.0507 0.0793
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0261 0.0306
Treponema pallidum heat shock protein 90 0.0031 0.019 0.0437
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0093 0.0088
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0461 0.5443 0.6502
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0057 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0052
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.0033
Schistosoma mansoni hypothetical protein 0.0171 0.1901 0.1897
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1917 1
Toxoplasma gondii methionine aminopeptidase 0.0057 0.0507 0.0925
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Plasmodium falciparum aminopeptidase P 0.0057 0.0507 0.0925
Echinococcus multilocularis GPCR, family 2 0.0019 0.0041 0.0041
Trichomonas vaginalis heat shock protein, putative 0.0031 0.019 0.0222
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0261 0.0471
Plasmodium falciparum heat shock protein 90 0.0039 0.0288 0.0521
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0057 0.0507 0.0601
Echinococcus granulosus dna polymerase kappa 0.0023 0.0093 0.0093
Schistosoma mansoni cpg binding protein 0.0039 0.0279 0.0275
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0064
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0093 0.0146
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0324 0.0511
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.034 0.1031
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0783 0.0779
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0461 0.5443 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0783 0.1431
Onchocerca volvulus 0.0043 0.034 0.0528
Plasmodium vivax methionine aminopeptidase 2, putative 0.0461 0.5443 1
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0288 0.0339
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0783 0.093
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0535
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0392 0.0392
Schistosoma mansoni peptidase 0.0057 0.0507 0.0503
Loa Loa (eye worm) hypothetical protein 0.0033 0.0206 0.0325
Echinococcus granulosus xaa Pro dipeptidase 0.0057 0.0507 0.0507
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0707 0.0703
Echinococcus multilocularis Proliferation associated protein 2G4 0.0057 0.0507 0.0507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0783 0.1233
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0324 0.0588
Trypanosoma cruzi aminopeptidase P, putative 0.0057 0.0507 0.0925
Echinococcus multilocularis cpg binding protein 0.0039 0.0279 0.0279
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0057 0.0507 0.0503
Trypanosoma brucei Metallopeptidase family M24, putative 0.0057 0.0507 0.0925
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0057 0.0507 0.0925
Onchocerca volvulus 0.0057 0.0507 0.0793
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.034 0.0335
Echinococcus granulosus methionine aminopeptidase type I 0.0057 0.0507 0.0507
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0057 0.0507 0.0503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0057 0.0507 0.0601
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0783 0.1431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.036 0.0567
Brugia malayi hypothetical protein 0.0016 0.0009 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0572 0.1044
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0041 0.0057
Mycobacterium ulcerans lipase LipD 0.0043 0.034 0.1534
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0057 0.0507 0.0925
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0057 0.0507 0.0925
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0324 0.0588
Loa Loa (eye worm) hypothetical protein 0.0057 0.0507 0.0799
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0041 0.0041
Plasmodium vivax FACT complex subunit SPT16, putative 0.0057 0.0507 0.0925
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0119 0.0211
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0392 0.1194
Giardia lamblia Xaa-Pro dipeptidase 0.0057 0.0507 0.0915
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Plasmodium vivax glutathione reductase, putative 0.0048 0.0392 0.0712
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1289 0.4001
Entamoeba histolytica peptidase, putative 0.0057 0.0507 0.0601
Mycobacterium leprae Probable lipase LipE 0.0043 0.034 0.0866
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.114 0.3536
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Entamoeba histolytica aminopeptidase, putative 0.0057 0.0507 0.0601
Plasmodium falciparum glutathione reductase 0.0017 0.001 0.001
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.007 0.0662 0.1042
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5849 0.5849
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0461 0.5443 0.6502
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0568
Mycobacterium ulcerans heat shock protein 90 0.0031 0.019 0.0838
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0311 0.0483
Plasmodium vivax endoplasmin, putative 0.0039 0.0288 0.0521
Brugia malayi metallopeptidase family M24 containing protein 0.0057 0.0507 0.0793
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.4125 0.7573
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0553 0.0553
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0093 0.0162
Onchocerca volvulus 0.0043 0.034 0.0528
Loa Loa (eye worm) DNA-binding protein 0.0057 0.0507 0.0799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Plasmodium vivax hypothetical protein, conserved 0.0043 0.034 0.0616
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0435 0.0792
Leishmania major hypothetical protein, conserved 0.0057 0.0507 0.0925
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Mycobacterium ulcerans dipeptidase 0.0057 0.0507 0.2316
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Echinococcus multilocularis heat shock protein 90 0.0039 0.0288 0.0288
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0261 0.0256
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0057 0.0507 0.0503
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0093 0.0385
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0783 0.1431
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0427
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0535
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0288 0.0521
Echinococcus multilocularis FACT complex subunit SPT16 0.0057 0.0507 0.0507
Brugia malayi heat shock protein 90 0.0039 0.0288 0.0447
Giardia lamblia Methionine aminopeptidase 0.0461 0.5443 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0093 0.0163
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0004 0.0007
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0392 0.0392
Toxoplasma gondii hypothetical protein 0.0059 0.0527 0.0961
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.034 0.0528
Chlamydia trachomatis aminopeptidase P 0.0057 0.0507 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0093 0.0162
Leishmania major trypanothione reductase 0.0048 0.0392 0.0712
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.034 0.0401
Mycobacterium tuberculosis Dipeptidase PepE 0.0057 0.0507 0.1556
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.001 0.0007
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0057 0.0507 0.0925
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.019 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0324 0.0588
Entamoeba histolytica methionine aminopeptidase, putative 0.0461 0.5443 0.6502
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0021 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.034 0.0616
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0057 0.0507 0.0925
Loa Loa (eye worm) hypothetical protein 0.0535 0.635 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0004 0.0004
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0057 0.0507 0.0925
Mycobacterium tuberculosis Conserved protein 0.0043 0.034 0.1031
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Echinococcus multilocularis zinc finger protein 0.0021 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0093 0.0162
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0041 0.0064
Loa Loa (eye worm) endoplasmin 0.0039 0.0288 0.0453
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0288 0.0521
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.034 0.0401
Brugia malayi beta-lactamase family protein 0.0043 0.034 0.0528
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0288 0.0521
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Trypanosoma brucei unspecified product 0.0023 0.0093 0.0163
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4125 0.4925
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0324 0.0382
Brugia malayi CXXC zinc finger family protein 0.0035 0.0232 0.0358
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.4268 0.784
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0544 0.085
Schistosoma mansoni bromodomain containing protein 0.0064 0.0596 0.0592
Loa Loa (eye worm) runx1 0.0067 0.0628 0.099
Mycobacterium ulcerans dipeptidase PepE 0.0057 0.0507 0.2316
Echinococcus granulosus zinc finger protein 0.0021 0.0068 0.0068
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0288 0.0521
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1289 0.6363
Schistosoma mansoni heat shock protein 0.0039 0.0288 0.0283
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Echinococcus multilocularis dna polymerase eta 0.0023 0.0093 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0232 0.0365
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.114 0.3536
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.2157 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0288 0.0521
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0372 0.0372
Onchocerca volvulus 0.0043 0.034 0.0528
Loa Loa (eye worm) beta-lactamase 0.0043 0.034 0.0535
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0242 0.0242
Brugia malayi metallopeptidase family M24 containing protein 0.0057 0.0507 0.0793
Leishmania major methionine aminopeptidase 2, putative 0.0461 0.5443 1
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0057 0.0507 0.0799
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0057 0.0507 0.0925
Leishmania major heat shock protein 83-1 0.0039 0.0288 0.0521
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0261 0.0306
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0461 0.5443 1
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.019 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0093 0.0163
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.4125 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.036 0.036
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0461 0.5443 0.8572
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0544 0.0857
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0535
Echinococcus granulosus transcription factor btf3 0.0042 0.0324 0.0324
Schistosoma mansoni endoplasmin 0.0039 0.0288 0.0283
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0288 0.0339
Mycobacterium ulcerans methionine aminopeptidase 0.0057 0.0507 0.2316
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0573 0.0573
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.546 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 1.236 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) > 55.7 um PUBCHEM_BIOASSAY: Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation. (Class of assay: confirmatory) [Related pubchem assays: 1267, 871, 932, 1309, 1318 ] ChEMBL. No reference
IC50 (functional) > 0.688 um PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT3 activation. (Class of assay: confirmatory) [Related pubchem assays: 1267, 871, 932, 1309, 1318 ] ChEMBL. No reference
IC50 (functional) = 7.3 uM PUBCHEM_BIOASSAY: SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1654, AID1661, AID1878] ChEMBL. No reference
IC50 (binding) = 24.96454 um PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 629 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (binding) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of DNA Polymerase Beta: Hit Validation in HIV-RT Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485311] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of DNA Polymerase Beta: Hit validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485311] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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