Detailed information for compound 660528

Basic information

Technical information
  • TDR Targets ID: 660528
  • Name: 4-methyl-N-[2-morpholin-4-yl-5-(trifluorometh yl)phenyl]-3-nitrobenzamide
  • MW: 409.359 | Formula: C19H18F3N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)[N+](=O)[O-])C)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
  • InChi: 1S/C19H18F3N3O4/c1-12-2-3-13(10-17(12)25(27)28)18(26)23-15-11-14(19(20,21)22)4-5-16(15)24-6-8-29-9-7-24/h2-5,10-11H,6-9H2,1H3,(H,23,26)
  • InChiKey: FQXTXIKGANBHCJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-N-[2-morpholino-5-(trifluoromethyl)phenyl]-3-nitro-benzamide
  • 4-methyl-N-[2-morpholino-5-(trifluoromethyl)phenyl]-3-nitrobenzamide
  • 4-methyl-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]-3-nitro-benzamide
  • ZINC01315721
  • STK118627

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0075 0.0423
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0234 0.0661
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0059 0.0519
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0862
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0059 0.0516
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0014 0.0023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.098 0.5511
Echinococcus granulosus prolyl endopeptidase 0.0028 0.0037 0.0115
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0119 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0089 0.0442
Mycobacterium tuberculosis Probable reductase 0.011 0.0239 0.0676
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0018 0.04
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0302 0.0714 0.3757
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Giardia lamblia PHD finger protein 15 0.0028 0.0037 0.1463
Schistosoma mansoni hypothetical protein 0.0183 0.0418 0.2189
Echinococcus multilocularis Smad4 0.0017 0.0009 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0058 0.005
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0206 0.1831
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0059 0.2203
Mycobacterium ulcerans transcriptional regulator 0.1403 0.3431 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0014 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0135
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0047
Brugia malayi MH2 domain containing protein 0.0017 0.0009 0.0049
Echinococcus multilocularis tar DNA binding protein 0.0388 0.0925 0.0917
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0075 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0089 0.0787
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0097
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0779 0.1889 0.754
Brugia malayi intermediate filament protein 0.0084 0.0175 0.0986
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0037 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0203 0.1143
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0089 0.0325
Brugia malayi hypothetical protein 0.0076 0.0154 0.0868
Loa Loa (eye worm) hypothetical protein 0.0084 0.0175 0.098
Schistosoma mansoni rab6-interacting 0.0019 0.0014 0.0043
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0037 0.0202
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0234 0.1318
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0242 0.0565 0.318
Schistosoma mansoni lamin 0.0084 0.0175 0.0899
Schistosoma mansoni bromodomain containing protein 0.0065 0.0128 0.0649
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0234 0.0661
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0078 0.0442
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0183 0.0418 0.1643
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0357 0.0848 0.7572
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0239 0.0676
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0129
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0037 0.1279
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0234 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0151 0.0845
Brugia malayi Serine protease Z688.6 precursor 0.0042 0.007 0.0395
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0388 0.0925 0.52
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.012 0.0263 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0059 0.0149
Brugia malayi beta-lactamase family protein 0.0108 0.0234 0.1318
Echinococcus granulosus lamin dm0 0.0084 0.0175 0.067
Loa Loa (eye worm) prolyl oligopeptidase 0.0357 0.0848 0.477
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0086 0.3443
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0154 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0037 0.0164
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0206 0.1153
Brugia malayi hypothetical protein 0.0049 0.0088 0.0494
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0234 0.8897
Schistosoma mansoni loxhd1 0.0019 0.0014 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Entamoeba histolytica hypothetical protein 0.0183 0.0418 1
Echinococcus granulosus RUN 0.0019 0.0014 0.0023
Onchocerca volvulus 0.015 0.0338 0.3012
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0157 0.0354 0.1985
Echinococcus granulosus geminin 0.0499 0.1199 0.4771
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0779 0.1889 0.1883
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0037 0.0206
Brugia malayi jmjC domain containing protein 0.0036 0.0057 0.0319
Plasmodium vivax glutathione reductase, putative 0.0048 0.0086 0.3443
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0024 0.0016
Trypanosoma brucei polo-like protein kinase 0.0097 0.0206 0.7817
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0175 0.098
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0154 0.5726
Loa Loa (eye worm) hypothetical protein 0.0733 0.1777 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0059 0.0283
Schistosoma mansoni smad1 5 8 and 0.0017 0.0009 0.0015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0009 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0183 0.0418 0.041
Mycobacterium tuberculosis Probable peptidase 0.0028 0.0037 0.0086
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0057 0.0313
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.0714 0.4016
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.007 0.0617
Mycobacterium ulcerans TetR family transcriptional regulator 0.1403 0.3431 1
Onchocerca volvulus 0.0059 0.0112 0.0993
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0089 0.3178
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.001 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0086 0.0312
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0075 0.0269
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0389
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0234 0.0617
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0019 0.0103
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.012 0.0263 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0692 0.1675 0.4872
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.0037 0.02
Leishmania major importin beta-1 subunit, putative 0.0023 0.0024 0.0857
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0112 0.0564
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.0714 0.4016
Echinococcus multilocularis geminin 0.0499 0.1199 0.1191
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.012 0.0263 1
Schistosoma mansoni lipoxygenase 0.0053 0.0099 0.0492
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.0037 0.1444
Schistosoma mansoni smad1 5 8 and 0.0017 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0071 0.0392
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.007 0.1656
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0089 0.0496
Brugia malayi MAP kinase sur-1 0.005 0.0089 0.0502
Loa Loa (eye worm) inositol-1 0.0037 0.0059 0.0327
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0059 0.0516
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0014 0.008
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0059 0.0516
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0014 0.0006
Brugia malayi jmjC domain containing protein 0.0093 0.0197 0.1108
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0024 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.0046
Loa Loa (eye worm) hypothetical protein 0.0083 0.0171 0.0959
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0485
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0024 0.0873
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0018 0.0657
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0008 0.0268
Entamoeba histolytica hypothetical protein 0.0023 0.0024 0.0538
Leishmania major GTP-binding protein, putative 0.0021 0.0018 0.0657
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0018 0.0657
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0014 0.0503
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.0046
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0242 0.0565 0.0557
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0059 0.0516
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0059 0.0519
Brugia malayi MH2 domain containing protein 0.0017 0.0009 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0065 0.0358
Echinococcus multilocularis prolyl endopeptidase 0.0028 0.0037 0.0029
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0175 0.098
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0008 0.0268
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0028 0.0037 0.1358
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0057 0.027
Loa Loa (eye worm) TAR-binding protein 0.0388 0.0925 0.52
Echinococcus granulosus zinc finger protein 0.002 0.0017 0.0035
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0357 0.0848 0.3367
Loa Loa (eye worm) hypothetical protein 0.0044 0.0076 0.0419
Onchocerca volvulus 0.015 0.0336 0.2994
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0239 0.0676
Schistosoma mansoni cellular tumor antigen P53 0.015 0.0338 0.1764
Mycobacterium leprae Probable lipase LipE 0.0108 0.0234 0.0617
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0014 0.0254
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.005 0.0124
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0008 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.0565 0.2969
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.007 0.0617
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0042 0.007 0.2635
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0239 0.063
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0059 0.1385
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.001 1
Trypanosoma cruzi prolyl endopeptidase 0.0028 0.0037 0.1358
Schistosoma mansoni tar DNA-binding protein 0.0388 0.0925 0.4878
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0008 0.0268
Trypanosoma cruzi oligopeptidase b 0.0028 0.0037 0.1358
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0037 0.1134
Brugia malayi RNA, U transporter 1 0.0081 0.0166 0.0933
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1403 0.3431 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0028 0.0037 0.0318
Echinococcus multilocularis tumor protein p63 0.1027 0.2503 0.2497
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0014 0.0312
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0234 0.0663
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0014 0.0503
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0037 0.1361
Mycobacterium ulcerans hypothetical protein 0.0023 0.0024 0.0046
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0075 0.0663
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0042 0.007 0.0617
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0012 0.0061
Brugia malayi Serine carboxypeptidase S28 family protein 0.0042 0.007 0.0395
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0014 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0001 0.0006
Brugia malayi Pre-SET motif family protein 0.041 0.098 0.5514
Giardia lamblia Kinase, PLK 0.0097 0.0206 1
Brugia malayi Fli-1 protein 0.0227 0.0526 0.2962
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0201
Loa Loa (eye worm) follicle stimulating hormone receptor 0.046 0.1103 0.6204
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0089 0.4097
Echinococcus multilocularis Dipeptidyl peptidase 9 0.012 0.0263 0.0255
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0269 0.0764
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0086 0.023
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0059 0.0516
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0389
Plasmodium falciparum phd finger protein, putative 0.0028 0.0037 0.1981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.0565 0.2969
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0135
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.001 0.0063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0234 0.0663
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0008 0.0268
Trypanosoma brucei glucosidase, putative 0.0037 0.0059 0.2203
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0037 0.0853
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0089 0.336
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.001 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0089 0.0787
Entamoeba histolytica hypothetical protein 0.0183 0.0418 1
Brugia malayi RNA binding protein 0.0388 0.0925 0.5203
Schistosoma mansoni hypothetical protein 0.0499 0.1199 0.6332
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0135
Schistosoma mansoni lamin 0.0084 0.0175 0.0899
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0028 0.0037 0.1358
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0024 0.0201
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0009 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0234 0.0906
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0352
Echinococcus multilocularis musashi 0.0084 0.0175 0.0167
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0059 0.2003
Brugia malayi PHD-finger family protein 0.0028 0.0037 0.0209
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.0336 0.1891
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0154 0.5841
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0014 0.0018
Mycobacterium ulcerans lipase LipD 0.0108 0.0234 0.0661
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0042 0.007 0.2635
Schistosoma mansoni hypothetical protein 0.0096 0.0203 0.1047
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0037 0.1361
Plasmodium falciparum peptidase, putative 0.0028 0.0037 0.1956
Toxoplasma gondii hypothetical protein 0.0028 0.0037 0.112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0008 0.0268
Loa Loa (eye worm) hypothetical protein 0.0302 0.0714 0.4012
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0067 0.0238
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0112 0.0564
Echinococcus multilocularis RUN 0.0019 0.0014 0.0006
Loa Loa (eye worm) RNA binding protein 0.0388 0.0925 0.52
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0112 0.0623
Onchocerca volvulus 0.0108 0.0234 0.2084
Brugia malayi Thioredoxin reductase 0.0048 0.0086 0.0484
Onchocerca volvulus 0.0157 0.0354 0.3151
Toxoplasma gondii ABC1 family protein 0.0108 0.0234 0.8866
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0028 0.0037 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0206 0.1062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0381 0.0374
Brugia malayi prolyl oligopeptidase family protein 0.0357 0.0848 0.4773
Brugia malayi beta-lactamase family protein 0.0108 0.0234 0.1318
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0075 0.0368
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0389
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0203 0.0782
Schistosoma mansoni transcription factor LCR-F1 0.0183 0.0418 0.2189
Plasmodium falciparum glutathione reductase 0.0048 0.0086 0.5331
Brugia malayi follicle stimulating hormone receptor 0.046 0.1103 0.6207
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0381 0.1496
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0089 0.0081
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0042 0.007 0.0617
Echinococcus multilocularis survival motor neuron protein 1 0.0733 0.1777 0.177
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0042 0.007 0.2432
Brugia malayi hypothetical protein 0.0183 0.0418 0.2353
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0381 0.2142
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0099 0.009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0268
Brugia malayi hypothetical protein 0.0019 0.0014 0.0078
Echinococcus granulosus Dipeptidyl peptidase 9 0.012 0.0263 0.1022
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0024 0.0549
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0239 0.0676
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0075 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0075 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0234 0.1213
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0076 0.0156 0.0148
Loa Loa (eye worm) Smad1 0.0017 0.0009 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0154 1
Trichomonas vaginalis esterase, putative 0.0108 0.0234 0.2084
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0515
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0206 0.4912
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0206 0.7817
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0086 0.3239
Brugia malayi PHD-finger family protein 0.0026 0.003 0.0171
Brugia malayi Smad1 0.0017 0.0009 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0234 0.2084
Brugia malayi hypothetical protein 0.0733 0.1777 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0024 0.0046
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0103
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1403 0.3431 1
Schistosoma mansoni importin beta-1 0.0028 0.0037 0.0164
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0381 0.0374
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0112 0.4079
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0024 0.0046
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0037 0.0853
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0009 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0154 0.5841
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0059 0.0331
Brugia malayi hypothetical protein 0.0019 0.0014 0.0078
Brugia malayi Bromodomain containing protein 0.004 0.0064 0.0363
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0037 0.0164
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Trypanosoma brucei ISWI complex protein 0.0016 0.0006 0.0181
Brugia malayi Inositol-1 0.0037 0.0059 0.0333
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0024 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0024 0.0873
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0059 0.0519
Brugia malayi beta-lactamase 0.0108 0.0234 0.1318
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0075 0.2828
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0024 0.0873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0242 0.0565 0.2232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0242 0.0565 0.0557
Mycobacterium ulcerans beta-lactamase 0.0108 0.0234 0.0661
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0024 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0037 0.1134
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0014 0.0118
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0014 0.0273
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0197 0.0189
Loa Loa (eye worm) hypothetical protein 0.0076 0.0156 0.087
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0112 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0012
Leishmania major oligopeptidase b 0.0028 0.0037 0.1358
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0234 0.1313
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.012 0.0263 1
Brugia malayi Pre-SET motif family protein 0.0059 0.0112 0.0631
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0234 0.8897
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0024 0.0046
Echinococcus multilocularis lamin dm0 0.0084 0.0175 0.0167
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0014 1
Schistosoma mansoni ran 0.0021 0.0018 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0009 0.0001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0059 0.2217
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0129
Loa Loa (eye worm) hypothetical protein 0.0108 0.0234 0.1313
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0203 0.1138
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0059 0.2217
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0234 0.8897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.0714 0.4012
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0043
Onchocerca volvulus 0.0084 0.0175 0.1556
Loa Loa (eye worm) hypothetical protein 0.0108 0.0234 0.1313
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0028 0.0037 0.1358
Toxoplasma gondii thioredoxin reductase 0.0048 0.0086 0.3053
Loa Loa (eye worm) beta-lactamase 0.0108 0.0234 0.1313
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.02
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0089 0.336
Schistosoma mansoni smad1 5 8 and 0.0017 0.0009 0.0015
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0357 0.0848 0.0841
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0018 0.0657
Brugia malayi hypothetical protein 0.0157 0.0354 0.199
Schistosoma mansoni Smad4 0.0017 0.0009 0.0015
Onchocerca volvulus 0.0042 0.007 0.0617
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0089 0.336
Brugia malayi prolyl oligopeptidase family protein 0.012 0.0263 0.1481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0075 0.1777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Echinococcus multilocularis GPCR, family 2 0.0096 0.0203 0.0195
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0028 0.0037 0.1358
Onchocerca volvulus 0.0019 0.0014 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0024 0.0046
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0037 0.0853
Onchocerca volvulus 0.0467 0.112 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0203 0.0782
Plasmodium falciparum importin beta, putative 0.0028 0.0037 0.1962
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0151 0.0143
Echinococcus granulosus intermediate filament protein 0.0084 0.0175 0.067
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0154 0.6459
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0042 0.007 0.0062
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.001 0.0024
Schistosoma mansoni survival motor neuron protein 0.015 0.0336 0.1753
Schistosoma mansoni gabp alpha 0.0075 0.0151 0.0771
Schistosoma mansoni hypothetical protein 0.0207 0.0477 0.2503
Echinococcus granulosus acylamino acid releasing enzyme 0.0028 0.0037 0.0115
Loa Loa (eye worm) hypothetical protein 0.0108 0.0234 0.1313
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0014 0.0021
Schistosoma mansoni inositol monophosphatase 0.0037 0.0059 0.0283
Onchocerca volvulus Alhambra homolog 0.0028 0.0037 0.0321
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0028 0.0037 0.0086
Trypanosoma brucei prolyl oligopeptidase, putative 0.0028 0.0037 0.1358
Leishmania major hypothetical protein, conserved 0.0076 0.0154 0.5841
Entamoeba histolytica Ran family GTPase 0.0021 0.0018 0.0413
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0206 0.0793
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0024 0.0857
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0059 0.2203
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0037 0.0166
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0028 0.0037 0.0318
Trichomonas vaginalis set domain proteins, putative 0.0467 0.112 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0065 0.0226
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0065 0.0056
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0014 0.0023
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0075 0.0368
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.001 0.0004
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0206 0.7817
Schistosoma mansoni hypothetical protein 0.0096 0.0203 0.1047
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0059 0.1393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0059 0.0051
Schistosoma mansoni smad 0.0017 0.0009 0.0015
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0206 0.7817
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0269 0.0719
Brugia malayi Importin beta-1 subunit 0.0028 0.0037 0.0207
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0037 0.0853
Schistosoma mansoni hypothetical protein 0.0096 0.0203 0.1047
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0024 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0206 0.1831
Schistosoma mansoni kinase 0.0049 0.0089 0.0441
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.001 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0268
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Echinococcus granulosus tumor protein p63 0.1027 0.2503 1
Leishmania major hypothetical protein, conserved 0.0016 0.0006 0.0181
Loa Loa (eye worm) hypothetical protein 0.0044 0.0075 0.0417
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0018 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0156 0.0795
Trichomonas vaginalis ran, putative 0.0021 0.0018 0.0154
Schistosoma mansoni hypothetical protein 0.015 0.0336 0.1753
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0018 0.0041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0059 0.1989
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0203 0.0195
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0197 0.0756
Echinococcus granulosus Smad4 0.0017 0.0009 0.0002
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0028 0.0037 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0086 0.0757
Loa Loa (eye worm) hypothetical protein 0.0207 0.0477 0.2682
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0234 0.0663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0242 0.0565 0.2232
Brugia malayi Doublecortin family protein 0.0019 0.0014 0.0078
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0037 0.0164
Leishmania major hypothetical protein, conserved 0.0108 0.0234 0.8897
Schistosoma mansoni hypothetical protein 0.0028 0.0037 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0024 0.0049
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0075 0.2828
Echinococcus multilocularis acylamino acid releasing enzyme 0.0028 0.0037 0.0029
Mycobacterium tuberculosis Conserved protein 0.0108 0.0234 0.0663
Echinococcus granulosus smad 0.0017 0.0009 0.0002
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.012 0.0263 0.1366
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0239 0.0676
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.001 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0067 0.0373
Brugia malayi MH2 domain containing protein 0.0249 0.0581 0.3267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.0565 0.2969
Schistosoma mansoni hypothetical protein 0.0096 0.0203 0.1047
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0009 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0089 0.0787
Loa Loa (eye worm) hypothetical protein 0.0092 0.0193 0.1082
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1403 0.3431 1
Brugia malayi TAR-binding protein 0.0388 0.0925 0.5203
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0242 0.0565 0.3176
Trypanosoma brucei protein kinase, putative 0.005 0.0089 0.336
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0089 0.336
Schistosoma mansoni tar DNA-binding protein 0.0388 0.0925 0.4878
Echinococcus granulosus snurportin 1 0.0302 0.0714 0.2827
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0154 0.5841
Plasmodium falciparum thioredoxin reductase 0.0048 0.0086 0.5331
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0175 0.0986
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0042 0.007 0.0617
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0075 0.3392
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0503
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0059 0.0205
Loa Loa (eye worm) hypothetical protein 0.015 0.0338 0.1898
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.005 0.0075
Schistosoma mansoni alpha-glucosidase 0.0145 0.0324 0.1688
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0024 0.0201
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0037 0.0116
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0037 0.0853
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0037 0.0029
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0698
Schistosoma mansoni zinc finger protein 0.002 0.0017 0.0058
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0028 0.0037 0.0037
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0037 0.0206
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.02
Schistosoma mansoni alpha glucosidase 0.0037 0.0059 0.0281
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0042 0.007 0.2635
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.0037 0.1444
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0059 0.0516
Schistosoma mansoni alpha-glucosidase 0.0145 0.0324 0.1688
Brugia malayi hypothetical protein 0.0092 0.0193 0.1088
Loa Loa (eye worm) fli-1 protein 0.0227 0.0526 0.2958
Echinococcus granulosus survival motor neuron protein 1 0.0733 0.1777 0.7089
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0051 0.0043
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0234 0.0663
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0028 0.0037 0.1358
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0014 0.0118
Onchocerca volvulus 0.0023 0.0024 0.0205
Loa Loa (eye worm) hypothetical protein 0.0108 0.0234 0.1313
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0047
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0089 0.336
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0037 0.1124
Echinococcus multilocularis zinc finger protein 0.002 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0129
Brugia malayi Bromodomain containing protein 0.0031 0.0043 0.0242
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0014 0.0394
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0389
Brugia malayi Bromodomain containing protein 0.0077 0.0158 0.0889
Brugia malayi glutathione reductase 0.0048 0.0086 0.0484
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0352
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.02
Mycobacterium tuberculosis Conserved protein 0.0108 0.0234 0.0663
Brugia malayi Serine protease Z688.6 precursor 0.0042 0.007 0.0395
Giardia lamblia Serine peptidase, putative 0.0042 0.007 0.3136
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0014 0.0074
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0779 0.1889 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0059 0.0203
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0024 0.0065
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0018 0.0451
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0078 0.0436
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0014 0.0072
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0357 0.0848 0.4472
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.007 0.1656
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0008 0.0046
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0059 0.0516
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0075 0.0067
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0206 0.1159
Mycobacterium ulcerans hypothetical protein 0.0108 0.0234 0.0661
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Plasmodium vivax SET domain protein, putative 0.0059 0.0112 0.46
Echinococcus multilocularis lamin 0.0084 0.0175 0.0167
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0202
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0503
Loa Loa (eye worm) hypothetical protein 0.0108 0.0234 0.1313
Toxoplasma gondii exonuclease III APE 0.0019 0.0014 0.0242
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.0046
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.001 0.0024
Schistosoma mansoni intermediate filament proteins 0.0084 0.0175 0.0899
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.012 0.0263 1
Schistosoma mansoni hypothetical protein 0.0499 0.1199 0.6332
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0014 0.0316
Loa Loa (eye worm) hypothetical protein 0.0064 0.0124 0.0694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0234 0.1213
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0014 0.0006
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0028 0.0037 0.112
Schistosoma mansoni ets-related 0.0227 0.0526 0.2763
Toxoplasma gondii prolyl endopeptidase 0.0028 0.0037 0.112
Echinococcus granulosus tar DNA binding protein 0.0388 0.0925 0.3673
Brugia malayi Ets-domain containing protein 0.0075 0.0151 0.085
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0089 0.336
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0037 0.1358
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0234 0.0663
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0119 0.0111
Entamoeba histolytica hypothetical protein 0.0183 0.0418 1
Brugia malayi MH1 domain containing protein 0.0017 0.0009 0.0049
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0028 0.0037 0.1358
Schistosoma mansoni rab6-interacting 0.0019 0.0014 0.0043
Onchocerca volvulus 0.0108 0.0234 0.2084
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0099 0.0362
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.0477 0.2686
Echinococcus multilocularis smad 0.0017 0.0009 0.0001
Onchocerca volvulus 0.0084 0.0175 0.1556
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0089 0.336
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0037 0.1358
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0059 0.2217
Mycobacterium tuberculosis Conserved protein 0.0108 0.0234 0.0663
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0089 0.0081
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.0581 0.3263
Plasmodium vivax importin-beta 2, putative 0.0028 0.0037 0.1267
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0075 0.0269
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.0714 0.4011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0024 0.0549
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0234 0.0663
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0075 0.2828
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0028 0.0037 0.0083
Echinococcus multilocularis snurportin 1 0.0302 0.0714 0.0706
Schistosoma mansoni jumonji domain containing protein 0.0074 0.015 0.0763
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0072
Trypanosoma brucei trypanothione reductase 0.0048 0.0086 0.3239
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0381 0.2147
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0037 0.0853
Echinococcus granulosus histone lysine methyltransferase setb 0.0076 0.0156 0.0591
Leishmania major trypanothione reductase 0.0048 0.0086 0.3239
Loa Loa (eye worm) glutathione reductase 0.0048 0.0086 0.0478
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0059 0.2203
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0059 0.0516
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.012 0.0263 1
Onchocerca volvulus 0.0019 0.0014 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0388 0.0925 0.4878
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0156 0.0795
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0239 0.0676
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0234 0.0226
Trypanosoma brucei prolyl endopeptidase 0.0028 0.0037 0.1358
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0089 0.0325
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0009 0.0043
Onchocerca volvulus 0.0108 0.0234 0.2084
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0059 0.2217
Schistosoma mansoni tar DNA-binding protein 0.0388 0.0925 0.4878
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.0581 0.3263
Trypanosoma cruzi ISWI complex protein 0.0016 0.0006 0.0181
Entamoeba histolytica hypothetical protein 0.0183 0.0418 1
Echinococcus multilocularis peregrin 0.0031 0.0043 0.0035
Schistosoma mansoni polycystin 1-related 0.0019 0.0014 0.0043
Loa Loa (eye worm) hypothetical protein 0.0073 0.0147 0.0822
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0037 0.1263
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.007 0.0617
Echinococcus granulosus importin subunit beta 1 0.0028 0.0037 0.0115
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0059 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0075 0.2828
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0203 0.1143
Echinococcus granulosus peregrin 0.0031 0.0043 0.014
Brugia malayi Ets-domain containing protein 0.0075 0.0151 0.085
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0234 0.2084
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0037 0.0206
Loa Loa (eye worm) hypothetical protein 0.0096 0.0203 0.1138
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0107 0.0395
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0057 0.0195
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0086 0.0078
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0067 0.0059
Schistosoma mansoni lipoxygenase 0.0019 0.0014 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0037 0.0318
Brugia malayi MH1 domain containing protein 0.0017 0.0009 0.0049
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0014 0.0006
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0086 0.0478
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0151 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0075 0.0663
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0057 0.027
Echinococcus granulosus lamin 0.0084 0.0175 0.067
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0014 0.0023
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.007 0.1656
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0045
Giardia lamblia Thymus-specific serine protease precursor 0.0042 0.007 0.3136
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0206 0.0198
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0014 0.0422
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0089 0.0787
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0234 0.2084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0058 0.0202
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0203 0.0195
Trypanosoma brucei oligopeptidase b 0.0028 0.0037 0.1358
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0234 0.0663
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0234 0.2084
Schistosoma mansoni hypothetical protein 0.0034 0.0051 0.0239
Schistosoma mansoni tar DNA-binding protein 0.0388 0.0925 0.4878
Brugia malayi RNA recognition motif domain containing protein 0.0388 0.0925 0.5203
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0008 0.0268
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0014 0.1207
Onchocerca volvulus 0.0097 0.0207 0.1837
Trypanosoma cruzi oligopeptidase b 0.0028 0.0037 0.1358
Schistosoma mansoni ran 0.0021 0.0018 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0234 0.2084
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0086 0.0757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0059 0.1385
Loa Loa (eye worm) hypothetical protein 0.0108 0.0234 0.1313
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0008 0.0063
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0052 0.0044
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0042 0.007 0.0249
Echinococcus granulosus GPCR family 2 0.0096 0.0203 0.0782
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0269 0.0764
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0269 0.0764
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0047
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0051 0.0171
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0059 0.0516
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0075 0.0663
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0059 0.0325
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0042 0.007 0.0341
Trypanosoma cruzi ISWI complex protein 0.0016 0.0006 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0268
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0059 0.0051
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0008 0.0268

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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