Detailed information for compound 66176

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 243.235 | Formula: C10H14FN3O3
  • H donors: 2 H acceptors: 2 LogP: -0.73 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC[C@H]1O[C@H](C[C@H]1N)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C10H14FN3O3/c1-5-4-14(10(16)13-9(5)15)8-2-6(12)7(3-11)17-8/h4,6-8H,2-3,12H2,1H3,(H,13,15,16)/t6-,7-,8-/m1/s1
  • InChiKey: MEDXRNYAGAIVHX-BWZBUEFSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Brugia malayi von Willebrand Factor 0.0048 0.0131 0.0414
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.0233 0.0233
Brugia malayi nuclear receptor RXR 0.0017 0.001 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.002
Onchocerca volvulus Putative nachr subunit 0.0021 0.0026 0.0071
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.0331 0.0331
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0117 0.0369
Chlamydia trachomatis endonuclease IV 0.0075 0.0234 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0054 0.0054
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0026 0.0059
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.001 0.0031
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0083 0.0231
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0048 0.0131 0.3163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0021 0.0026 0.0081
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.084 0.194
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0026 0.0081
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0171 0.1868
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0131 0.3163
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0234 0.6129
Brugia malayi Kringle domain containing protein 0.0024 0.0036 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0083 0.0263
Echinococcus multilocularis lamin dm0 0.0083 0.0266 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0141 0.3525
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.009 0.009
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.0233 0.0537
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0059 0.1386
Onchocerca volvulus 0.0017 0.001 0.0027
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0238 0.0868 0.2746
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0036 0.0532
Echinococcus granulosus RUN 0.002 0.002 0.002
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0369 0.0852
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.009 0.3775
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0083 0.0263
Echinococcus multilocularis bloom syndrome protein 0.004 0.0101 0.0101
Echinococcus multilocularis serotonin transporter 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0063
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.0026 0.0026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0091 0.3832
Schistosoma mansoni survival motor neuron protein 0.0049 0.0133 0.0306
Echinococcus granulosus serotonin transporter 0.0015 0.0003 0.0003
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0331 0.0765
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0093 0.0294
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0003 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0021 0.0026 0.0026
Schistosoma mansoni DNA helicase recq5 0.0028 0.0054 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Onchocerca volvulus 0.0048 0.0131 0.0363
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Onchocerca volvulus 0.0048 0.0131 0.0363
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0093 0.0214
Mycobacterium ulcerans epimerase 0.002 0.002 0.0107
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.001 0.0022
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0369 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0089 0.0089
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.152 0.152
Trichomonas vaginalis rotamase, putative 0.0032 0.007 0.0164
Schistosoma mansoni slit 0.0054 0.0154 0.0355
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0083 0.0263
Brugia malayi hypothetical protein 0.0051 0.0141 0.0447
Brugia malayi hypothetical protein 0.0033 0.0072 0.0226
Echinococcus granulosus histone lysine methyltransferase setb 0.0119 0.0408 0.0408
Schistosoma mansoni gabp alpha 0.0071 0.022 0.0508
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0131 0.3547
Brugia malayi nuclear receptor NHR-88 0.0017 0.001 0.0031
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0083 0.0083
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Schistosoma mansoni nuclear receptor 0.0017 0.001 0.0022
Echinococcus granulosus expressed protein 0.0033 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0059 0.2427
Entamoeba histolytica hypothetical protein 0.0048 0.0131 0.3547
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.007 0.0763
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0054 0.0054
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0102
Brugia malayi laminin alpha chain 0.0054 0.0154 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0083 0.0263
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0004 0.0041
Schistosoma mansoni hypothetical protein 0.0406 0.152 0.351
Echinococcus granulosus cpg binding protein 0.003 0.0061 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0089 0.0205
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0089 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0083 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0141 0.5999
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0141 0.3525
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0021 0.0026 0.0081
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0004 0.0041
Brugia malayi Doublecortin family protein 0.002 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0089 0.0089
Echinococcus multilocularis dna polymerase eta 0.0019 0.0018 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0083 0.0083
Schistosoma mansoni loxhd1 0.002 0.002 0.0046
Brugia malayi hypothetical protein 0.0106 0.0356 0.1126
Echinococcus multilocularis slit 2 protein 0.0054 0.0154 0.0154
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0059 0.0644
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0083 0.0192
Onchocerca volvulus 0.0048 0.0131 0.0363
Schistosoma mansoni hypothetical protein 0.0023 0.0033 0.0075
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.009 0.5
Echinococcus granulosus pikachurin 0.0054 0.0154 0.0154
Onchocerca volvulus 0.0021 0.0026 0.0071
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0021 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0018 0.0077
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0036 0.0036
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0109 0.0368 0.1165
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0032 0.0102
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Onchocerca volvulus 0.0024 0.0036 0.0101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.001 0.001
Brugia malayi hypothetical protein 0.002 0.002 0.0063
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Trichomonas vaginalis set domain proteins, putative 0.0943 0.3607 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.009 0.2061
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0032 0.0102
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.0026 0.0026
Plasmodium falciparum LCCL domain-containing protein 0.002 0.002 0.0748
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0141 0.3525
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0388 0.0388
Onchocerca volvulus 0.0015 0.0003 0.0008
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0059 0.607
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.009 0.0221
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0018 0.0018
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0021 0.0026 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Brugia malayi hypothetical protein 0.0019 0.0018 0.0056
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.0154 0.0154
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0408 0.0942
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0083 0.0083
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0045 0.0104
Loa Loa (eye worm) hypothetical protein 0.0075 0.0234 0.074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0018 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.001 0.001
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.0331 0.0331
Entamoeba histolytica hypothetical protein 0.0038 0.0093 0.2517
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0003 0.0003
Toxoplasma gondii subtilisin SUB12 0.0015 0.0004 0.0041
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0141
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.0233 0.0233
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0089 0.0792
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.001 0.0031
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0018 0.0018
Echinococcus granulosus geminin 0.0168 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0168 0.0597 0.1378
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0141 0.5999
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0266 0.0842
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0021 0.0026 0.0026
Brugia malayi Pre-SET motif family protein 0.0119 0.0408 0.1289
Toxoplasma gondii hypothetical protein 0.0015 0.0004 0.0041
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0026 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.009 0.2061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0034
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1178 0.4518 0.4518
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0048 0.0131 0.1432
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0914 0.211
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0093 0.0093
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.01 0.01
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.025 0.0914 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.009 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.084 0.2657
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Onchocerca volvulus 0.0021 0.0026 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0083 0.0263
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0369 0.3967
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0093 0.0294
Brugia malayi nuclear hormone receptor 0.0017 0.001 0.0031
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0093 0.0093
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.007 0.1483
Schistosoma mansoni rotamase 0.0033 0.0073 0.0168
Echinococcus multilocularis cpg binding protein 0.003 0.0061 0.0061
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0003 0.0006
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0083 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0036 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0173
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0083 0.0083
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0083 0.0231
Echinococcus multilocularis expressed protein 0.0033 0.0073 0.0073
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0369 0.1167
Toxoplasma gondii microneme protein MIC2 0.0048 0.0131 0.1432
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0018 0.0056
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0073 0.023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0089 0.028
Echinococcus multilocularis expressed protein 0.0746 0.2841 0.2841
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0003 0.0003
Toxoplasma gondii exonuclease III APE 0.0038 0.009 0.0986
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0083 0.0192
Plasmodium vivax SET domain protein, putative 0.0119 0.0408 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0194 0.0194
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0017 0.001 0.0022
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.0009
Brugia malayi nuclear receptor NHR-88 0.0036 0.0083 0.0263
Brugia malayi excitatory GABA receptor EXP-1A 0.0021 0.0026 0.0081
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0093 0.0093
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0194 0.0613
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0003 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.001 0.0027
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0048 0.0131 0.5539
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0093 0.0093
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0089 0.0205
Brugia malayi PXA domain containing protein 0.0038 0.0093 0.0294
Schistosoma mansoni DNA helicase recq1 0.0028 0.0054 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0083 0.0263
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0036 0.0398
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0083 0.0263
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0083 0.0263
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.009 0.0285
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0234 0.074
Brugia malayi nuclear receptor RXR 0.0019 0.0018 0.0056
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.3068 0.3068
Onchocerca volvulus 0.0015 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.025 0.0914 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0003 0.0006
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0021 0.0026 0.0081
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0093 0.0093
Loa Loa (eye worm) LGC-31 protein 0.0021 0.0026 0.0081
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0018 0.0041
Echinococcus multilocularis pikachurin 0.0054 0.0154 0.0154
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.0022
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0194 0.0447
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0093 0.0093
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0131 0.0414
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0021 0.0026 0.0081
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0093 0.0294
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.0588
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) glutamate receptor 0.0089 0.0289 0.0913
Loa Loa (eye worm) CUTiclin-Like family member 0.0048 0.0131 0.0414
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0083 0.0083
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0003 0.0003
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0021 0.0026 0.0059
Brugia malayi Ets-domain containing protein 0.0071 0.022 0.0696
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Treponema pallidum hypothetical protein 0.0048 0.0131 0.0243
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.002 0.0107
Echinococcus granulosus dnaJ subfamily B 0.0406 0.152 0.152
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0026 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0408 0.0942
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0083 0.0192
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Brugia malayi Ets-domain containing protein 0.0071 0.022 0.0696
Loa Loa (eye worm) ACC-1 protein 0.0021 0.0026 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0083 0.0263
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Treponema pallidum 76K protein 0.0048 0.0131 0.0243
Loa Loa (eye worm) hypothetical protein 0.004 0.01 0.0315
Schistosoma mansoni thyroid hormone receptor 0.0291 0.1074 0.2481
Brugia malayi tailless protein 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0059 0.0644
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0194 0.1966
Loa Loa (eye worm) DR-78 0.0017 0.001 0.0031
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0021 0.0026 0.0081
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0018 0.0056
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0369 0.0852
Toxoplasma gondii microneme protein MIC4 0.0015 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0196 0.0452
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0003 0.0009
Brugia malayi ecdysteroid receptor 0.0036 0.0083 0.0263
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0093 0.0093
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0119 0.0408 0.0408
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0101 0.032
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0026 0.0081
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0112 0.0354
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Schistosoma mansoni lipoxygenase 0.002 0.002 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0083 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0083 0.0083
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0093 0.0093
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0868 0.0868
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0083 0.0263
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.022 0.022
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0036 0.1452
Onchocerca volvulus 0.0015 0.0004 0.001
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0101 0.0252
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0194 0.5014
Echinococcus multilocularis geminin 0.0168 0.0597 0.0597
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Loa Loa (eye worm) glutamate receptor 0.0035 0.008 0.0252
Brugia malayi Fli-1 protein 0.0216 0.0782 0.2472
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0018 0.0077
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0369 0.0695
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0064 0.1723
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.009 0.2441
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Toxoplasma gondii hypothetical protein 0.0015 0.0003 0.003
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0234 0.571
Onchocerca volvulus 0.0015 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.01 0.0331 0.1048
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0021 0.0026 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0914 1
Echinococcus granulosus lamin 0.0083 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0369 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.007 0.1483
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0296
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0021 0.0026 0.0026
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.001 0.001
Echinococcus multilocularis lamin 0.0083 0.0266 0.0266
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0083 0.0083
Toxoplasma gondii aldehyde dehydrogenase 0.025 0.0914 1
Schistosoma mansoni ets-related 0.0216 0.0782 0.1805
Plasmodium falciparum thrombospondin-related anonymous protein 0.0048 0.0131 0.5539
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0034
Schistosoma mansoni coup transcription factor 0.0036 0.0083 0.0192
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0093 0.0294
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0157 0.0157
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0083 0.0192
Onchocerca volvulus 0.0051 0.0143 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0083 0.0263
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.0026 0.0026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0083 0.0192
Echinococcus granulosus collagen alpha 1VII chain 0.0048 0.0131 0.0131
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0093 0.0214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.007 0.0582
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0117 0.0369
Onchocerca volvulus 0.0036 0.0083 0.0231
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0089 0.0089
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0077
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0093 0.0294
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0059 0.1596
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.003
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0003 0.0009
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0026 0.0081
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.009 0.2156
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0143 0.033
Brugia malayi Cation transporter family protein 0.0021 0.0026 0.0081
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0026 0.0026
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0093 0.0294
Loa Loa (eye worm) abnormal epIthelia family member 0.0054 0.0154 0.0486
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.0026 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0266 0.0842
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0101 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0083 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0083 0.0263
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0914 0.211
Schistosoma mansoni DNA polymerase eta 0.0019 0.0018 0.0041
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.007 0.1891
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0157 0.0157
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0486
Brugia malayi Nuclear hormone receptor E75 0.0017 0.001 0.0031
Onchocerca volvulus 0.0021 0.0026 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0486
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Brugia malayi PXA domain containing protein 0.0038 0.0093 0.0294
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0083 0.0192
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0194 0.5014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0003 0.0006
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0255 0.0935 0.2159
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0018
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0369 1
Schistosoma mansoni hypothetical protein 0.0049 0.0133 0.0306
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0083 0.0083
Loa Loa (eye worm) doublecortin family protein 0.002 0.002 0.0063
Echinococcus granulosus dna polymerase kappa 0.0019 0.0018 0.0018
Onchocerca volvulus 0.0015 0.0004 0.001
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0256 0.081
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0083 0.0192
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Schistosoma mansoni nuclear hormone receptor 0.0017 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Giardia lamblia DINP protein human, muc B family 0.0019 0.0018 0.0873
Brugia malayi Cation transporter family protein 0.0021 0.0026 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0083 0.0263
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0101 0.0336 0.0776
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0003 0.0006
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Brugia malayi hypothetical protein 0.0038 0.0093 0.0294
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0089 0.0089
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.001 0.001
Onchocerca volvulus 0.002 0.002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.009 0.0808
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0216 0.0682
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0089 0.0205
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.001 0.001
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0089 0.982
Onchocerca volvulus 0.0015 0.0004 0.001
Entamoeba histolytica hypothetical protein 0.0038 0.0093 0.2517
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Schistosoma mansoni lamin 0.0083 0.0266 0.0615
Onchocerca volvulus 0.0015 0.0003 0.0008
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0291 0.1074 0.2481
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0059 0.0134
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.009 0.0221
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.084 0.084
Toxoplasma gondii hypothetical protein 0.0015 0.0003 0.003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0026 0.0081
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0021 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0083 0.0263
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.001 0.0022
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2589 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.0026 0.0026
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0369 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0064 0.1307
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0005 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.002 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0447
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0026 0.0081
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0026 0.0026
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.0935 0.0935
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0003 0.0003
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0093 0.0214
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0054 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0829 0.3162 1
Brugia malayi Nuclear hormone receptor E75 0.0017 0.001 0.0031
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Onchocerca volvulus 0.0048 0.0131 0.0363
Echinococcus granulosus bloom syndrome protein 0.004 0.0101 0.0101
Brugia malayi hypothetical protein 0.0017 0.0011 0.0034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0033 0.0033
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0296
Loa Loa (eye worm) CUTiclin family member 0.0048 0.0131 0.0414
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0141 0.3425
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.0009
Brugia malayi steroid hormone receptor 0.0036 0.0083 0.0263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Mycobacterium ulcerans hypothetical protein 0.002 0.002 0.0107
Mycobacterium ulcerans endonuclease IV 0.0075 0.0234 0.2473
Plasmodium vivax thrombospondin-related anonymous protein 0.0048 0.0131 0.3163
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0026 0.0026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0194 0.5014
Entamoeba histolytica hypothetical protein 0.0038 0.0093 0.2517
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.001 0.0031
Onchocerca volvulus 0.0119 0.0408 0.1131
Echinococcus granulosus dna polymerase eta 0.0019 0.0018 0.0018
Onchocerca volvulus 0.0048 0.0131 0.0363
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Onchocerca volvulus 0.0015 0.0004 0.001
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0868 0.0868
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0003 0.0006
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0369 1
Brugia malayi intermediate filament protein 0.0083 0.0266 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.015
Brugia malayi EGF-like domain containing protein 0.0054 0.0154 0.0486
Schistosoma mansoni laminin gamma-3 chain 0.0054 0.0154 0.0355
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0048 0.0131 0.0334
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.003
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0093 0.0228
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0073 0.023
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.025 0.0914 0.0914
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0289 0.0913
Schistosoma mansoni hypothetical protein 0.0037 0.0089 0.0205
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0234 0.2473
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0093 0.0294
Echinococcus multilocularis musashi 0.0083 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0077
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0048 0.0131 0.3163
Brugia malayi hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi hypothetical protein 0.0243 0.0889 0.2811
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0093 0.0093
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0093 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Leishmania major hypothetical protein, conserved 0.0051 0.0141 0.1382
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0368 0.0368
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0083 0.0263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.002 0.0056
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0369 0.0369
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Loa Loa (eye worm) hypothetical protein 0.0521 0.1969 0.6225
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Brugia malayi Pre-SET motif family protein 0.0829 0.3162 1
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0048 0.0131 0.3163
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0054 0.0154 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0093 0.0214
Entamoeba histolytica elongation factor-2 kinase, putative 0.0048 0.0131 0.3547
Schistosoma mansoni hypothetical protein 0.0608 0.2306 0.5325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0083 0.0263
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0107
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0083 0.0083
Brugia malayi hypothetical protein 0.002 0.002 0.0063
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.002 0.002
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0003 0.0006
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.001 0.001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0021 0.0026 0.0026
Brugia malayi hypothetical protein 0.0037 0.0089 0.028
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.084 0.084
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1371 0.5269 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0064 0.1307
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0093 0.0294
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0089 0.0089
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0093 0.0214
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.0026 0.0026
Schistosoma mansoni ap endonuclease 0.0038 0.009 0.0208
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0011 0.003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0021 0.0026 0.0081
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0331 0.0765
Brugia malayi hypothetical protein 0.0015 0.0003 0.0009
Echinococcus granulosus intermediate filament protein 0.0083 0.0266 0.0266
Brugia malayi follicle stimulating hormone receptor 0.0238 0.0868 0.2744
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Onchocerca volvulus 0.0028 0.0055 0.0152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0083 0.0083
Schistosoma mansoni serine-rich repeat protein 0.0608 0.2306 0.5325
Onchocerca volvulus 0.0017 0.001 0.0027
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.01 0.01
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0064 0.0147
Onchocerca volvulus 0.0015 0.0004 0.001
Brugia malayi Cache domain containing protein 0.0521 0.1969 0.6225
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0842
Brugia malayi hypothetical protein 0.0038 0.0093 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0018 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0089 0.0217
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0046
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0093 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0093 0.0093
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0021 0.0026 0.0081
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0003 0.0003
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0089 0.2402
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0089 0.0089
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.0588
Brugia malayi Protein kinase domain containing protein 0.0024 0.0036 0.0115
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0302
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0093 0.0294
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Onchocerca volvulus 0.0015 0.0004 0.001
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0004 0.0041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0026 0.0081
Onchocerca volvulus 0.0048 0.0131 0.0363
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.002
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0036 0.0829
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0032 0.0102
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0021 0.0026 0.0081
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0054 0.2206
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.001 0.0027
Brugia malayi ecdysone receptor 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0119 0.0408 0.1289
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0083 0.0231
Onchocerca volvulus 0.0021 0.0026 0.0071
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.017
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0003 0.0006
Schistosoma mansoni nAChR subunit 0.0021 0.0026 0.0059
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0089 0.2021
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0018 0.0019
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.025 0.0914 0.0914
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.0868 0.2744
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0021 0.0026 0.0081
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.009 0.2061
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0059 0.2427
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0021 0.0026 0.0026
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0048 0.0131 0.5539
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Loa Loa (eye worm) hypothetical protein 0.0081 0.026 0.0823
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0369 0.392
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0369 0.1167
Onchocerca volvulus 0.0083 0.0266 0.0738
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0119 0.0408 0.4463
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0093 0.0093
Schistosoma mansoni intermediate filament proteins 0.0083 0.0266 0.0615
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0083 0.0263
Onchocerca volvulus 0.0021 0.0026 0.0071
Schistosoma mansoni nuclear receptor 0.0017 0.001 0.0022
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0083 0.0263
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0914 1
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0059 0.2427
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.001 0.001
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0004 0.0041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0063
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Onchocerca volvulus 0.0943 0.3607 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0021 0.0026 0.0026
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0083 0.0263
Echinococcus granulosus voltage dependent calcium channel subunit 0.1178 0.4518 0.4518
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.0009
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0064 0.0513
Brugia malayi hypothetical protein 0.0019 0.0018 0.0056
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0234 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0083 0.0263
Schistosoma mansoni cpg binding protein 0.0028 0.0055 0.0126
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.0026 0.0081
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Brugia malayi hypothetical protein 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.009 0.0285
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0119 0.0408 0.0408
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0083 0.0192
Echinococcus multilocularis tumor protein p63 0.035 0.1303 0.1302
Onchocerca volvulus 0.0083 0.0266 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0093 0.0214
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0026 0.0081
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.002 0.0427
Echinococcus multilocularis thyroid hormone receptor alpha 0.0291 0.1074 0.1074
Schistosoma mansoni cell polarity protein 0.0054 0.0154 0.0355
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0089 0.0217
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0059 0.2427
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0119 0.0408 0.0942
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0093 0.0294
Loa Loa (eye worm) hypothetical protein 0.01 0.0331 0.1048
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0093 0.0093
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0003 0.0009
Leishmania major hypothetical protein, conserved 0.0024 0.0036 0.0209
Onchocerca volvulus 0.0021 0.0026 0.0071
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0194 0.5252
Echinococcus granulosus nAChR subunit 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0059 0.0107
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0003 0.0003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0018 0.0478
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0369 0.3967
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.0935 0.0935
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0093 0.0294
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0021 0.0026 0.0059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.009 0.0879
Onchocerca volvulus 0.0048 0.0131 0.0363
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0054 0.017
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.001 0.0031
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0059 0.1386
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0036 0.0036
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0569 0.2156 0.4977
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0018
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0046
Toxoplasma gondii microneme protein, putative 0.0015 0.0004 0.0041
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.001 0.0031
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0263
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0368 0.0368
Schistosoma mansoni lipoxygenase 0.0055 0.0157 0.0362
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0089 0.028
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0302
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0093 0.0214
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0133 0.0419
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0059 0.0644
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0018 0.0019
Brugia malayi Cytochrome P450 family protein 0.007 0.0216 0.0682
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0026 0.0026
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.001 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0018 0.0041
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.007 0.1483
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0131 0.3547
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0914 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) fli-1 protein 0.0216 0.0782 0.2472
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.001 0.001
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.001 0.001
Brugia malayi hypothetical protein 0.0017 0.001 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0089 0.0089
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0369 0.1167
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0194 0.0194
Schistosoma mansoni polycystin 1-related 0.002 0.002 0.0046
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0054 0.0154 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0083 0.0263
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Schistosoma mansoni lamin 0.0083 0.0266 0.0615
Schistosoma mansoni ap endonuclease 0.0038 0.009 0.0208
Echinococcus granulosus lamin dm0 0.0083 0.0266 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0093 0.0214
Onchocerca volvulus 0.0049 0.0133 0.0368
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0089 0.2021
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0369 1
Brugia malayi hypothetical protein 0.0238 0.0868 0.2746
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0003 0.0003
Echinococcus granulosus tumor protein p63 0.035 0.1303 0.1302
Brugia malayi phosphofructokinase 0.0109 0.0369 0.1167
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi 6-phosphofructokinase 0.0109 0.0369 0.1167
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.001 0.0022
Loa Loa (eye worm) RecQ helicase 0.004 0.0101 0.032
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.009 0.0879
Echinococcus granulosus expressed protein 0.0746 0.2841 0.2841
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0021 0.0026 0.0059
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0112 0.0259
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0331 0.0765
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0021 0.0026 0.0026
Echinococcus granulosus slit 2 protein 0.0054 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0369 0.0369
Brugia malayi Sulfatase family protein 0.0017 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0266 0.0842
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.009 0.0166
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0018 0.0056
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.001 0.0031
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0026 0.0059
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.009 0.009
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0003 0.0009
Toxoplasma gondii endonuclease IV APN 0.0075 0.0234 0.2561
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0084
Loa Loa (eye worm) ACC-1 protein 0.0021 0.0026 0.0081
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0061 0.018 0.0569
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0141 0.1548
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0021 0.0026 0.0081
Brugia malayi conserved hypotetical protein 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0051 0.0143 0.0452
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.022 0.0696
Onchocerca volvulus 0.002 0.002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0634 0.2406 0.7609
Brugia malayi CXXC zinc finger family protein 0.0028 0.0055 0.0173
Onchocerca volvulus 0.0015 0.0003 0.0008
Brugia malayi nuclear receptor NHR-67 0.0017 0.001 0.0031
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0033 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0054 0.0054
Toxoplasma gondii hypothetical protein 0.0015 0.0004 0.0041
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0004 0.0041
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.017
Trichomonas vaginalis rotamase, putative 0.0033 0.0073 0.0173
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0018 0.0041
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1129 0.4331 1
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0083 0.0263
Brugia malayi 6-phosphofructokinase 0.0109 0.0369 0.1167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Echinococcus multilocularis nAChR subunit 0.0021 0.0026 0.0026
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0089 0.2021
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0083 0.0192
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0048 0.0131 0.0131
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0083 0.0263
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0031
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0003 0.0009
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0038 0.086
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0486
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0054 0.5426
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0089 0.0217
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0089 0.0089
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Echinococcus multilocularis RUN 0.002 0.002 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0083 0.0083
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0093 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0055 0.0173
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0194 0.0613
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.022 0.022
Schistosoma mansoni hypothetical protein 0.0168 0.0597 0.1378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0408 0.0942
Brugia malayi laminin-like protein K08C7.3 precursor 0.0054 0.0154 0.0486
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0035 0.0388
Brugia malayi nuclear hormone receptor 0.0036 0.0083 0.0263
Brugia malayi Cation transporter family protein 0.0021 0.0026 0.0081

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 83 % Inhibitory activity against thymidine kinase (TK) from L1210 cells ChEMBL. 6644738
Activity (binding) = 83 % Inhibitory activity against thymidine kinase (TK) from L1210 cells ChEMBL. 6644738
Activity (binding) = 88 % Inhibitory activity against deoxycytidine kinase from L1210 cells ChEMBL. 6644738
Activity (binding) = 88 % Inhibitory activity against deoxycytidine kinase from L1210 cells ChEMBL. 6644738
Activity (binding) = 89 % Inhibitory activity against thymidine kinase (TK) from L1210 cells ChEMBL. 6644738
Activity (binding) = 89 % Inhibitory activity against thymidine kinase (TK) from L1210 cells ChEMBL. 6644738
Activity (binding) = 91 % Inhibitory activity against deoxycytidine kinase from L1210 cells ChEMBL. 6644738
Activity (binding) = 91 % Inhibitory activity against deoxycytidine kinase from L1210 cells ChEMBL. 6644738
ED50 (functional) 0 uM In vitro inhibition against replication of L1210 murine cells; inactive ChEMBL. 6644738
ED50 (functional) 0 uM In vitro inhibition against replication of Sarcoma-80 cells; inactive ChEMBL. 6644738

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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