Detailed information for compound 680645

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.379 | Formula: C15H17N3O2S
  • H donors: 2 H acceptors: 3 LogP: 2.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)Cc1csc(n1)NC(=O)c1ccccc1
  • InChi: 1S/C15H17N3O2S/c1-2-8-16-13(19)9-12-10-21-15(17-12)18-14(20)11-6-4-3-5-7-11/h3-7,10H,2,8-9H2,1H3,(H,16,19)(H,17,18,20)
  • InChiKey: TWLNPNHSQDSGMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0114 0.0518
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0187 0.0901 0.4181
Schistosoma mansoni hypothetical protein 0.0048 0.0162 0.0443
Treponema pallidum sodium- and chloride- dependent transporter 0.0176 0.084 0.3889
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0045 0.0147
Loa Loa (eye worm) hypothetical protein 0.0257 0.1272 0.4594
Toxoplasma gondii hypothetical protein 0.0026 0.0045 0.0081
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.016 0.0438
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0114 0.0518
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0114 0.0412
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0068 0.019
Schistosoma mansoni hypothetical protein 0.03 0.15 0.4099
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0487 0.3366
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0062 0.0161
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0416 0.2116 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0954 0.2596
Echinococcus multilocularis ras GTP exchange factor 0.0019 0.0005 0.0000060855
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0256 0.0911
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0196 0.0534
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.016 0.0563
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.0005 0.0000093347
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.0063 0.0212
Brugia malayi mbt repeat family protein 0.0048 0.016 0.0563
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0224 0.0601
Echinococcus granulosus intermediate filament protein 0.0085 0.0355 0.0957
Echinococcus multilocularis tumor protein p63 0.0336 0.1693 0.3989
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Echinococcus granulosus microtubule associated protein 2 0.0706 0.3661 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0306 0.0711
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0136 0.0629 0.2959
Toxoplasma gondii exonuclease III APE 0.0039 0.0114 0.0412
Plasmodium vivax amine transporter, putative 0.003 0.0063 0.0168
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0567 0.2038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0424
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.0063 0.0059
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0114 0.0518
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0954 0.2243
Brugia malayi TAR-binding protein 0.0066 0.0256 0.0911
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0345 0.1232
Brugia malayi N-terminal motif family protein 0.0019 0.0005 0.0000093347
Schistosoma mansoni hypothetical protein 0.0516 0.2648 0.7232
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1898 1 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.0005 0.0013
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.0063 0.016
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0538 0.2763 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0063 0.0173
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0647 0.3043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.1272 0.4594
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0147
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0114 0.011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0114 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0111
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0416 0.2116 0.4989
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.2382 0.6502
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0045 0.0147
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0019 0.0005 0.0000060855
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.0005 0.0013
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.0005 0.0000093347
Leishmania major DNA polymerase eta, putative 0.0031 0.0068 0.0299
Toxoplasma gondii hypothetical protein 0.003 0.0063 0.0168
Schistosoma mansoni dishevelled 0.0026 0.0045 0.0124
Schistosoma mansoni lamin 0.0085 0.0355 0.0969
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0114 0.0397
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0062 0.0161
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.4236 1
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0146 0.0511
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0045 0.0111
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0062 0.0161
Echinococcus multilocularis musashi 0.0085 0.0355 0.0827
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0062 0.0058
Echinococcus granulosus son of sevenless 1 0.0019 0.0005 0.0000070429
Brugia malayi PHD-finger family protein 0.0025 0.0038 0.012
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.1272 0.4594
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0187 0.0901 0.3249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0632 0.1714
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0632 0.2272
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0224 0.0519
Brugia malayi hypothetical protein 0.0075 0.0306 0.1091
Echinococcus granulosus tar DNA binding protein 0.0066 0.0256 0.0687
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0063 0.0173
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0045 0.0096
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0125 0.057
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0487 0.1748
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0187 0.0901 0.4181
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0151 0.0346
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.016 0.0425
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Echinococcus granulosus ras GTP exchange factor 0.0019 0.0005 0.0000070429
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0028 0.0024
Onchocerca volvulus 0.0029 0.006 0.0199
Mycobacterium ulcerans hypothetical protein 0.0155 0.0731 0.0727
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0062 0.027
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0151 0.0413
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0063 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0416 0.2116 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0337 0.0909
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.016 0.0367
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0063 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0632 0.1481
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0114 0.0412
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0005 0.0001
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0046 0.0151 0.053
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0345 0.0929
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0136 0.0629 0.2959
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0062 0.0058
Echinococcus multilocularis son of sevenless 1 0.0019 0.0005 0.0000060855
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0122 0.0277
Schistosoma mansoni lamin 0.0085 0.0355 0.0969
Loa Loa (eye worm) hypothetical protein 0.0176 0.084 0.3028
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Brugia malayi MH2 domain containing protein 0.0125 0.0567 0.2038
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0147
Loa Loa (eye worm) RNA binding protein 0.0066 0.0256 0.0911
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0187 0.0901 0.2461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1474 0.6959
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.016 0.0425
Schistosoma mansoni intermediate filament proteins 0.0085 0.0355 0.0969
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0416 0.2116 1
Loa Loa (eye worm) MBCTL1 0.0055 0.0196 0.0691
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0028 0.0024
Brugia malayi 6-phosphofructokinase 0.011 0.0487 0.1748
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0062 0.0161
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0487 0.2284
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0054 0.0134
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0062 0.027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0146 0.0511
Onchocerca volvulus 0.0231 0.1135 0.4098
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.016 0.0438
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1168 0.3181
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0166 0.0454
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0632 0.2272
Loa Loa (eye worm) hypothetical protein 0.0176 0.084 0.3028
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0063 0.0173
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0487 0.2284
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0019 0.0005 0.0000060855
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0125 0.057
Brugia malayi RNA binding protein 0.0066 0.0256 0.0911
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Schistosoma mansoni z-protein (S1r protein) 0.0026 0.0045 0.0124
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0487 0.2284
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0487 0.2284
Toxoplasma gondii hypothetical protein 0.003 0.0063 0.0168
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0306 0.0835
Onchocerca volvulus 0.0085 0.0355 0.1269
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0063 0.0138
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0416 0.2116 0.5773
Loa Loa (eye worm) solute carrier family 6 member 4 0.0176 0.084 0.3028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0147
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0026 0.0045 0.0124
Brugia malayi Bromodomain containing protein 0.0076 0.0306 0.1093
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0125 0.057
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0187 0.0901 0.2451
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0000093347
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0176 0.084 0.2295
Brugia malayi DIX domain containing protein 0.0026 0.0045 0.0147
Loa Loa (eye worm) serotonin transporter b 0.0176 0.084 0.3028
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0063 0.0173
Brugia malayi Pre-SET motif family protein 0.0203 0.0986 0.3557
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0137 0.0627
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0487 0.133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0731 0.0727
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0114 0.0518
Loa Loa (eye worm) hypothetical protein 0.0055 0.0196 0.0691
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.0839 0.3026
Schistosoma mansoni dishevelled 0.0026 0.0045 0.0124
Leishmania major DNA polymerase eta, putative 0.0044 0.0137 0.0627
Brugia malayi 6-phosphofructokinase 0.011 0.0487 0.1748
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.006 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0041
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Brugia malayi hypothetical protein 0.0238 0.1168 0.4216
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0062 0.0161
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0647 0.3043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.006 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0632 0.1481
Onchocerca volvulus 0.003 0.0063 0.0212
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0168
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1898 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0114 0.0518
Brugia malayi RasGEF domain containing protein 0.0019 0.0005 0.0000093347
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0196 0.0691
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0097 0.0218
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.0063 0.0138
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0567 0.2038
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0487 0.1748
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0306 0.0823
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0062 0.027
Loa Loa (eye worm) hypothetical protein 0.0044 0.0137 0.048
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0045 0.0111
Brugia malayi RasGEF domain containing protein 0.0019 0.0005 0.0000093347
Echinococcus granulosus Pleckstrin G protein interacting region 0.0026 0.0045 0.0111
Echinococcus granulosus lamin dm0 0.0085 0.0355 0.0957
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0487 0.1319
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0000093347
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0176 0.084 0.3028
Brugia malayi RasGEF domain containing protein 0.0019 0.0005 0.0000093347
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Brugia malayi N-terminal motif family protein 0.0019 0.0005 0.0000093347
Echinococcus granulosus zinc finger protein 0.002 0.0009 0.0013
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0355 0.1269
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0487 0.0483
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.2382 0.5618
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0487 0.0483
Loa Loa (eye worm) hypothetical protein 0.0538 0.2763 1
Brugia malayi hypothetical protein 0.003 0.0063 0.0212
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0279 0.1391 1
Echinococcus granulosus serotonin transporter 0.0176 0.084 0.2284
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0487 0.2197
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0028 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0632 0.1725
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0986 0.3557
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0196 0.0521
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0487 0.2284
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0416 0.2116 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0337 0.0786
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0005 0.0001
Echinococcus granulosus GPCR family 2 0.0081 0.0337 0.0909
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0045 0.0124
Echinococcus granulosus dna polymerase eta 0.0044 0.0137 0.0362
Loa Loa (eye worm) hypothetical protein 0.0238 0.1168 0.4216
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0563
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0114 0.0397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0632 0.1714
Onchocerca volvulus 0.0048 0.016 0.0563
Plasmodium falciparum phenylalanine--tRNA ligase 0.0155 0.0729 0.3358
Plasmodium falciparum phenylalanine--tRNA ligase 0.0187 0.0901 0.4181
Schistosoma mansoni hypothetical protein 0.0516 0.2648 0.7232
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0045 0.0096
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0416 0.2116 0.5779
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0063 0.016
Echinococcus granulosus lamin 0.0085 0.0355 0.0957
Plasmodium falciparum transporter, putative 0.003 0.0063 0.0168
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0062 0.0161
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0114 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0337 0.1205
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Brugia malayi Pre-SET motif family protein 0.0029 0.006 0.0199
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.0063 0.0173
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0063 0.0173
Loa Loa (eye worm) hypothetical protein 0.0083 0.0345 0.1232
Echinococcus multilocularis Protein son of sevenless 0.0019 0.0005 0.0000060855
Loa Loa (eye worm) hypothetical protein 0.0176 0.084 0.3028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0465
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0025 0.0048
Echinococcus granulosus Protein son of sevenless 0.0019 0.0005 0.0000070429
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0015 0.0037
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0005 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0151 0.04
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0355 0.1269
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0019 0.0005 0.0000070429
Echinococcus multilocularis GPCR, family 2 0.0081 0.0337 0.0786
Loa Loa (eye worm) phosphofructokinase 0.011 0.0487 0.1748
Onchocerca volvulus 0.003 0.0063 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0151 0.0413
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0256 0.0594
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0063 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Echinococcus granulosus geminin 0.0516 0.2648 0.7229
Loa Loa (eye worm) hypothetical protein 0.0071 0.0283 0.101
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0026 0.0045 0.0146
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0125 0.057
Echinococcus granulosus neuropeptide s receptor 0.0466 0.2382 0.6502
Brugia malayi regulator of G-protein signaling egl-10 0.0026 0.0045 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0632 0.1725
Loa Loa (eye worm) hypothetical protein 0.0041 0.0123 0.0428
Echinococcus multilocularis lamin 0.0085 0.0355 0.0827
Brugia malayi mbt repeat family protein 0.0048 0.016 0.0563
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.006 0.013
Loa Loa (eye worm) hypothetical protein 0.0081 0.0337 0.1205
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.0382
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0137 0.048
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0487 0.2284
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.2382 0.5618
Schistosoma mansoni bromodomain containing protein 0.0064 0.0244 0.0666
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0256 0.0911
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0487 0.133
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0114 0.0518
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0416 0.2116 0.7652
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0345 0.0941
Brugia malayi Bromodomain containing protein 0.0039 0.011 0.038
Loa Loa (eye worm) hypothetical protein 0.0176 0.0839 0.3026
Loa Loa (eye worm) hypothetical protein 0.0416 0.2116 0.7652
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0045 0.0096
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0345 0.0803
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0122 0.032
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0025 0.0056
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.016 0.0438
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0647 0.3043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.006 0.0163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0114 0.0412
Schistosoma mansoni hypothetical protein 0.0176 0.0839 0.2293
Onchocerca volvulus 0.0176 0.084 0.3028
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0355 0.1269
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1168 0.2748
Echinococcus granulosus tumor protein p63 0.0336 0.1693 0.4617
Schistosoma mansoni ras GTP exchange factor 0.0019 0.0005 0.0013
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0005 0.0013
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0062 0.0161
Schistosoma mansoni hypothetical protein 0.0075 0.0306 0.0835
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0063 0.0173
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0063 0.0173
Brugia malayi hypothetical protein 0.0026 0.0045 0.0147
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0187 0.0901 0.3249
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0063 0.016
Schistosoma mansoni survival motor neuron protein 0.0048 0.0162 0.0443
Plasmodium vivax hypothetical protein, conserved 0.003 0.0063 0.0168
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.0394
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.0005 0.0000093347
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.016 0.0367
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0114 0.0518
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0068 0.0299
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0168
Echinococcus multilocularis dna polymerase eta 0.0044 0.0137 0.0313
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0111
Schistosoma mansoni ap endonuclease 0.0039 0.0114 0.0312
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0416 0.2116 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0063 0.0173
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1898 1 1
Schistosoma mansoni dep domain containing protein 0.0026 0.0045 0.0124
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0026 0.0045 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0632 0.1725
Schistosoma mansoni DNA polymerase eta 0.0044 0.0137 0.0375
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0337 0.0909
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0196 0.0451
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0114 0.0259
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0136 0.0629 0.172
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.0063 0.0138
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0062 0.0161
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0256 0.0911
Brugia malayi N-terminal motif family protein 0.0538 0.2763 1
Toxoplasma gondii hypothetical protein 0.0048 0.0158 0.062
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0005 0.0001
Echinococcus multilocularis geminin 0.0516 0.2648 0.6246
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0137 0.0627
Loa Loa (eye worm) hypothetical protein 0.0083 0.0347 0.1239
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1474 0.6959
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0168
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1474 0.6959
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0028 0.0024
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.0063 0.0138
Plasmodium vivax SET domain protein, putative 0.0029 0.006 0.015
Onchocerca volvulus 0.0083 0.0345 0.1231
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0114 0.0299
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0026 0.0045 0.0147
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0187 0.0901 0.2118
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0196 0.0521
Loa Loa (eye worm) hypothetical protein 0.0049 0.0166 0.0585
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0487 0.1139
Schistosoma mansoni zinc finger protein 0.002 0.0009 0.0026
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0416 0.2116 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0025 0.0069
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0337 0.0786
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0196 0.0451
Plasmodium falciparum amino acid transporter, putative 0.003 0.0063 0.0168
Echinococcus multilocularis zinc finger protein 0.002 0.0009 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0114 0.0518
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0136 0.0629 0.288
Onchocerca volvulus 0.003 0.0063 0.0212
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.0063 0.016
Schistosoma mansoni sodium/chloride dependent transporter 0.0176 0.084 0.2295
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Brugia malayi intermediate filament protein 0.0085 0.0355 0.1269
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0337 0.1205
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0045 0.0096
Onchocerca volvulus 0.0048 0.0162 0.057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0162 0.057
Echinococcus multilocularis serotonin transporter 0.0176 0.084 0.1974
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.3661 1
Onchocerca volvulus 0.0026 0.0045 0.0146
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0063 0.0173
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0097 0.0252
Loa Loa (eye worm) hypothetical protein 0.0085 0.0355 0.1269
Loa Loa (eye worm) DIX domain-containing protein 0.0026 0.0045 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1135 0.5356
Loa Loa (eye worm) norepinephrine transporter 0.0176 0.084 0.3028
Brugia malayi hypothetical protein 0.0026 0.0045 0.0147
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.016 0.0563
Onchocerca volvulus 0.0049 0.0166 0.0585
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1474 0.6959
Brugia malayi phosphofructokinase 0.011 0.0487 0.1748
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0019 0.0005 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0337 0.1205
Onchocerca volvulus 0.0085 0.0355 0.1269
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.3661 0.8641
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0174 0.0799
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.1272 0.4594
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0045 0.0111
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0063 0.016
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0045 0.0111
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.0394
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0019 0.0005 0.0000070429
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Schistosoma mansoni ap endonuclease 0.0039 0.0114 0.0312
Echinococcus multilocularis lamin dm0 0.0085 0.0355 0.0827

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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