Detailed information for compound 680725

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.406 | Formula: C16H19N3O2S
  • H donors: 2 H acceptors: 3 LogP: 2.7 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CNC(=O)Cc1csc(n1)NC(=O)c1ccccc1)C
  • InChi: 1S/C16H19N3O2S/c1-11(2)9-17-14(20)8-13-10-22-16(18-13)19-15(21)12-6-4-3-5-7-12/h3-7,10-11H,8-9H2,1-2H3,(H,17,20)(H,18,19,21)
  • InChiKey: NUJMSAGLKJHGGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0114 0.011
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1168 0.2748
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.0063 0.0138
Brugia malayi 6-phosphofructokinase 0.011 0.0487 0.1748
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0176 0.084 0.2295
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0063 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0151 0.0413
Brugia malayi hypothetical protein 0.003 0.0063 0.0212
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0416 0.2116 1
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0355 0.1269
Echinococcus multilocularis ras GTP exchange factor 0.0019 0.0005 0.0000060855
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0025 0.0048
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0487 0.2284
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0424
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0028 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0256 0.0911
Brugia malayi N-terminal motif family protein 0.0538 0.2763 1
Schistosoma mansoni lamin 0.0085 0.0355 0.0969
Plasmodium falciparum amino acid transporter, putative 0.003 0.0063 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0632 0.1481
Echinococcus granulosus Protein son of sevenless 0.0019 0.0005 0.0000070429
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0487 0.1319
Loa Loa (eye worm) solute carrier family 6 member 4 0.0176 0.084 0.3028
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0306 0.0835
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0487 0.133
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0015 0.0037
Echinococcus multilocularis geminin 0.0516 0.2648 0.6246
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0187 0.0901 0.2451
Loa Loa (eye worm) hypothetical protein 0.0176 0.084 0.3028
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0487 0.1139
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0028 0.0111
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0025 0.0069
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0538 0.2763 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0337 0.1205
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.006 0.0163
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.0005 0.0000093347
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0125 0.057
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0256 0.0594
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.0063 0.016
Plasmodium falciparum phenylalanine--tRNA ligase 0.0187 0.0901 0.4181
Loa Loa (eye worm) hypothetical protein 0.0044 0.0137 0.048
Toxoplasma gondii hypothetical protein 0.003 0.0063 0.0168
Schistosoma mansoni DNA polymerase eta 0.0044 0.0137 0.0375
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0045 0.0111
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0025 0.0056
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0063 0.0173
Schistosoma mansoni z-protein (S1r protein) 0.0026 0.0045 0.0124
Onchocerca volvulus 0.0085 0.0355 0.1269
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.016 0.0438
Onchocerca volvulus 0.0083 0.0345 0.1231
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0062 0.0161
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0063 0.0173
Loa Loa (eye worm) MBCTL1 0.0055 0.0196 0.0691
Loa Loa (eye worm) hypothetical protein 0.0238 0.1168 0.4216
Schistosoma mansoni sodium/chloride dependent transporter 0.0176 0.084 0.2295
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.2382 0.6502
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0345 0.0941
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0416 0.2116 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0416 0.2116 1
Loa Loa (eye worm) phosphofructokinase 0.011 0.0487 0.1748
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0063 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0632 0.1725
Schistosoma mansoni dep domain containing protein 0.0026 0.0045 0.0124
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0114 0.0518
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0416 0.2116 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.0005 0.0000093347
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0731 0.0727
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.3661 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0487 0.0483
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.0005 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0114 0.0518
Brugia malayi RasGEF domain containing protein 0.0019 0.0005 0.0000093347
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.0063 0.0138
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0647 0.3043
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0487 0.1748
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0114 0.011
Schistosoma mansoni zinc finger protein 0.002 0.0009 0.0026
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0114 0.0518
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0187 0.0901 0.4181
Brugia malayi 6-phosphofructokinase 0.011 0.0487 0.1748
Echinococcus granulosus lamin 0.0085 0.0355 0.0957
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0487 0.2197
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0146 0.0511
Echinococcus multilocularis dna polymerase eta 0.0044 0.0137 0.0313
Toxoplasma gondii hypothetical protein 0.0048 0.0158 0.062
Toxoplasma gondii hypothetical protein 0.003 0.0063 0.0168
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.0382
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.0063 0.0138
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0337 0.1205
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.0063 0.016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0005 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0256 0.0911
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0196 0.0521
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.016 0.0563
Echinococcus granulosus lamin dm0 0.0085 0.0355 0.0957
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0026 0.0045 0.0124
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0045 0.0111
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1474 0.6959
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0005 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0345 0.1232
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0487 0.133
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0196 0.0691
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0306 0.0823
Plasmodium vivax hypothetical protein, conserved 0.003 0.0063 0.0168
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.2382 0.5618
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0416 0.2116 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0063 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0632 0.1725
Brugia malayi DIX domain containing protein 0.0026 0.0045 0.0147
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0068 0.019
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0416 0.2116 0.5779
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0647 0.3043
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.0005 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Onchocerca volvulus 0.0048 0.016 0.0563
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0122 0.0277
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0137 0.0627
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0062 0.0161
Brugia malayi N-terminal motif family protein 0.0019 0.0005 0.0000093347
Brugia malayi MH2 domain containing protein 0.0125 0.0567 0.2038
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.016 0.0438
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0125 0.057
Onchocerca volvulus 0.0085 0.0355 0.1269
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0063 0.016
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0487 0.2284
Brugia malayi hypothetical protein 0.0238 0.1168 0.4216
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0632 0.2272
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0487 0.1748
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0162 0.057
Onchocerca volvulus 0.0176 0.084 0.3028
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1474 0.6959
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0176 0.084 0.3028
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0068 0.0299
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0063 0.0173
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0487 0.2284
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0062 0.0161
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0063 0.0173
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0005 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0224 0.0601
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Schistosoma mansoni ras GTP exchange factor 0.0019 0.0005 0.0013
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0063 0.0173
Echinococcus granulosus Pleckstrin G protein interacting region 0.0026 0.0045 0.0111
Schistosoma mansoni hypothetical protein 0.0516 0.2648 0.7232
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0045 0.0096
Loa Loa (eye worm) hypothetical protein 0.0416 0.2116 0.7652
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.0839 0.3026
Leishmania major DNA polymerase eta, putative 0.0044 0.0137 0.0627
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0306 0.0711
Echinococcus granulosus microtubule associated protein 2 0.0706 0.3661 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0045 0.0147
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0632 0.1481
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Onchocerca volvulus 0.0231 0.1135 0.4098
Brugia malayi N-terminal motif family protein 0.0019 0.0005 0.0000093347
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0062 0.027
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0196 0.0521
Echinococcus multilocularis zinc finger protein 0.002 0.0009 0.0011
Schistosoma mansoni bromodomain containing protein 0.0064 0.0244 0.0666
Brugia malayi hypothetical protein 0.0026 0.0045 0.0147
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0063 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0632 0.1725
Onchocerca volvulus 0.0026 0.0045 0.0146
Brugia malayi Pre-SET motif family protein 0.0029 0.006 0.0199
Brugia malayi mbt repeat family protein 0.0048 0.016 0.0563
Onchocerca volvulus 0.003 0.0063 0.0212
Echinococcus multilocularis musashi 0.0085 0.0355 0.0827
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0019 0.0005 0.0000060855
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0212
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0097 0.0218
Loa Loa (eye worm) hypothetical protein 0.0071 0.0283 0.101
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.0005 0.0000093347
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0000093347
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.006 0.0163
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0122 0.032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0125 0.057
Echinococcus granulosus neuropeptide s receptor 0.0466 0.2382 0.6502
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0174 0.0799
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0063 0.0173
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.006 0.015
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0028 0.0024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0168
Echinococcus granulosus dna polymerase eta 0.0044 0.0137 0.0362
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0063 0.0173
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0114 0.0518
Onchocerca volvulus 0.003 0.0063 0.0212
Brugia malayi intermediate filament protein 0.0085 0.0355 0.1269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0114 0.0518
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0045 0.0124
Brugia malayi phosphofructokinase 0.011 0.0487 0.1748
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0019 0.0005 0.0000060855
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0026 0.0045 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0337 0.0786
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0632 0.1714
Plasmodium vivax SET domain protein, putative 0.0029 0.006 0.015
Onchocerca volvulus 0.0048 0.0162 0.057
Echinococcus granulosus tar DNA binding protein 0.0066 0.0256 0.0687
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0062 0.0161
Brugia malayi TAR-binding protein 0.0066 0.0256 0.0911
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0337 0.0909
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0019 0.0005 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0005 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.1272 0.4594
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.0063 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.016 0.0425
Brugia malayi Bromodomain containing protein 0.0039 0.011 0.038
Echinococcus granulosus tumor protein p63 0.0336 0.1693 0.4617
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.0063 0.0173
Echinococcus granulosus geminin 0.0516 0.2648 0.7229
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.0063 0.0059
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0136 0.0629 0.288
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0137 0.0627
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0114 0.0412
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0147
Echinococcus multilocularis lamin dm0 0.0085 0.0355 0.0827
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0954 0.2596
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0487 0.2284
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0114 0.0397
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0114 0.0412
Brugia malayi hypothetical protein 0.0026 0.0045 0.0147
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0196 0.0451
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0151 0.0346
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0019 0.0005 0.0013
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0187 0.0901 0.3249
Plasmodium falciparum phenylalanine--tRNA ligase 0.0155 0.0729 0.3358
Loa Loa (eye worm) DIX domain-containing protein 0.0026 0.0045 0.0147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.0394
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0146 0.0511
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0063 0.0173
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.1272 0.4594
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0487 0.2284
Brugia malayi RNA binding protein 0.0066 0.0256 0.0911
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0045 0.0111
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0114 0.0518
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0062 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1474 0.6959
Onchocerca volvulus 0.0049 0.0166 0.0585
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.016 0.0367
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0151 0.0413
Schistosoma mansoni dishevelled 0.0026 0.0045 0.0124
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0954 0.2243
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0166 0.0585
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1135 0.5356
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.1272 0.4594
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.4236 1
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0136 0.0629 0.2959
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0224 0.0519
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0062 0.0161
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0187 0.0901 0.4181
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1898 1 1
Onchocerca volvulus 0.003 0.0063 0.0212
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0026 0.0045 0.0147
Schistosoma mansoni lamin 0.0085 0.0355 0.0969
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0337 0.0909
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0632 0.2272
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0416 0.2116 0.4989
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0114 0.0412
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0019 0.0005 0.0000070429
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.016 0.0438
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0487 0.2284
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0005 0.0001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0063 0.0173
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Echinococcus granulosus intermediate filament protein 0.0085 0.0355 0.0957
Schistosoma mansoni intermediate filament proteins 0.0085 0.0355 0.0969
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0187 0.0901 0.3249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0114 0.0397
Plasmodium falciparum transporter, putative 0.003 0.0063 0.0168
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0487 0.3366
Loa Loa (eye worm) hypothetical protein 0.0046 0.0151 0.053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0337 0.0786
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0062 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0000093347
Echinococcus multilocularis GPCR, family 2 0.0081 0.0337 0.0786
Loa Loa (eye worm) hypothetical protein 0.0055 0.0196 0.0691
Loa Loa (eye worm) hypothetical protein 0.0041 0.0123 0.0428
Onchocerca volvulus 0.0029 0.006 0.0199
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0147
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.016 0.0367
Loa Loa (eye worm) hypothetical protein 0.0176 0.0839 0.3026
Mycobacterium ulcerans hypothetical protein 0.0155 0.0731 0.0727
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0647 0.3043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0005 0.0001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0196 0.0451
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0416 0.2116 0.5773
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0416 0.2116 0.7652
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0187 0.0901 0.2461
Toxoplasma gondii hypothetical protein 0.0026 0.0045 0.0081
Echinococcus granulosus son of sevenless 1 0.0019 0.0005 0.0000070429
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0355 0.1269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0632 0.1714
Loa Loa (eye worm) hypothetical protein 0.0081 0.0337 0.1205
Plasmodium vivax amine transporter, putative 0.003 0.0063 0.0168
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1168 0.3181
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0465
Brugia malayi Bromodomain containing protein 0.0076 0.0306 0.1093
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0136 0.0629 0.172
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0062 0.0161
Loa Loa (eye worm) hypothetical protein 0.0538 0.2763 1
Brugia malayi Pre-SET motif family protein 0.0203 0.0986 0.3557
Loa Loa (eye worm) hypothetical protein 0.0083 0.0347 0.1239
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1898 1 1
Brugia malayi hypothetical protein 0.0075 0.0306 0.1091
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0062 0.0058
Toxoplasma gondii exonuclease III APE 0.0039 0.0114 0.0412
Schistosoma mansoni hypothetical protein 0.0048 0.0162 0.0443
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0355 0.1269
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0063 0.0138
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0045 0.0096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0147
Schistosoma mansoni hypothetical protein 0.03 0.15 0.4099
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0345 0.0803
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1898 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0256 0.0911
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1474 0.6959
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0563
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0337 0.1205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.006 0.013
Brugia malayi regulator of G-protein signaling egl-10 0.0026 0.0045 0.0147
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0019 0.0005 0.0000070429
Echinococcus granulosus ras GTP exchange factor 0.0019 0.0005 0.0000070429
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0567 0.2038
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0062 0.0161
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0168
Schistosoma mansoni ap endonuclease 0.0039 0.0114 0.0312
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0416 0.2116 1
Loa Loa (eye worm) serotonin transporter b 0.0176 0.084 0.3028
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0114 0.011
Echinococcus multilocularis tumor protein p63 0.0336 0.1693 0.3989
Echinococcus granulosus zinc finger protein 0.002 0.0009 0.0013
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0187 0.0901 0.2118
Loa Loa (eye worm) RNA binding protein 0.0066 0.0256 0.0911
Echinococcus multilocularis serotonin transporter 0.0176 0.084 0.1974
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0028 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0125 0.057
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0136 0.0629 0.2959
Loa Loa (eye worm) norepinephrine transporter 0.0176 0.084 0.3028
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0026 0.0045 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.2382 0.5618
Brugia malayi mbt repeat family protein 0.0048 0.016 0.0563
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.0394
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0097 0.0252
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.016 0.0425
Leishmania major DNA polymerase eta, putative 0.0031 0.0068 0.0299
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0063 0.0173
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0062 0.027
Treponema pallidum sodium- and chloride- dependent transporter 0.0176 0.084 0.3889
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.3661 0.8641
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0345 0.0929
Schistosoma mansoni survival motor neuron protein 0.0048 0.0162 0.0443
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0045 0.0111
Echinococcus granulosus serotonin transporter 0.0176 0.084 0.2284
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0114 0.0518
Brugia malayi PHD-finger family protein 0.0025 0.0038 0.012
Echinococcus granulosus GPCR family 2 0.0081 0.0337 0.0909
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0111
Loa Loa (eye worm) hypothetical protein 0.0257 0.1272 0.4594
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0196 0.0534
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0212
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Loa Loa (eye worm) hypothetical protein 0.0083 0.0345 0.1232
Echinococcus multilocularis Protein son of sevenless 0.0019 0.0005 0.0000060855
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0114 0.0518
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0045 0.0096
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Schistosoma mansoni ap endonuclease 0.0039 0.0114 0.0312
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0567 0.2038
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Loa Loa (eye worm) hypothetical protein 0.0176 0.084 0.3028
Schistosoma mansoni hypothetical protein 0.0075 0.0306 0.0835
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0487 0.2284
Loa Loa (eye worm) hypothetical protein 0.0085 0.0355 0.1269
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0416 0.2116 1
Schistosoma mansoni hypothetical protein 0.0081 0.0337 0.0921
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0986 0.3557
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0256 0.07
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0151 0.04
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0045 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0062 0.027
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0487 0.0483
Schistosoma mansoni hypothetical protein 0.0176 0.0839 0.2293
Entamoeba histolytica hypothetical protein 0.0075 0.0306 0.1425
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0062 0.027
Schistosoma mansoni dishevelled 0.0026 0.0045 0.0124
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.016 0.0563
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0063 0.0168
Echinococcus multilocularis lamin 0.0085 0.0355 0.0827
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0279 0.1391 1
Schistosoma mansoni hypothetical protein 0.0516 0.2648 0.7232
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0045 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0111
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0166 0.0454
Brugia malayi RasGEF domain containing protein 0.0019 0.0005 0.0000093347
Echinococcus multilocularis son of sevenless 1 0.0019 0.0005 0.0000060855
Loa Loa (eye worm) hypothetical protein 0.0176 0.084 0.3028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0114 0.0259
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0114 0.0299
Brugia malayi RasGEF domain containing protein 0.0019 0.0005 0.0000093347
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0137 0.048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0054 0.0134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.