Detailed information for compound 686161

Basic information

Technical information
  • TDR Targets ID: 686161
  • Name: 4-[(4-chlorophenyl)sulfonylamino]-N-(3-cyanot hiophen-2-yl)benzamide
  • MW: 417.889 | Formula: C18H12ClN3O3S2
  • H donors: 2 H acceptors: 4 LogP: 4.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccsc1NC(=O)c1ccc(cc1)NS(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C18H12ClN3O3S2/c19-14-3-7-16(8-4-14)27(24,25)22-15-5-1-12(2-6-15)17(23)21-18-13(11-20)9-10-26-18/h1-10,22H,(H,21,23)
  • InChiKey: MSEMCANBRMSIGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(4-chlorophenyl)sulfonylamino]-N-(3-cyano-2-thienyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0028 0.0165
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0186 0.1963 0.2655
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0397
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.5342 0.5342
Schistosoma mansoni hypothetical protein 0.0031 0.0171 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.1086 0.1085
Loa Loa (eye worm) hypothetical protein 0.024 0.2589 0.2585
Schistosoma mansoni fkbp-rapamycin associated protein 0.0167 0.1743 0.1742
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0474 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0028 0.0165
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0057 0.0474 1
Leishmania major hypothetical protein, conserved 0.0057 0.0474 0.0473
Brugia malayi hypothetical protein 0.0025 0.01 0.01
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0057 0.0474 0.0473
Echinococcus multilocularis serine protein kinase ATM 0.0167 0.1743 0.1742
Schistosoma mansoni hypothetical protein 0.0165 0.172 0.1719
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.5342 0.5342
Toxoplasma gondii target of rapamycin (TOR), putative 0.0656 0.7391 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0057 0.0474 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0028 0.0165
Brugia malayi intermediate filament protein 0.0054 0.0442 0.0442
Loa Loa (eye worm) RNA binding protein 0.0062 0.0531 0.0526
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0028 0.0165
Echinococcus granulosus pyruvate kinase 0.0018 0.0021 0.0019
Echinococcus granulosus GPCR family 2 0.0031 0.0171 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.2549 0.2548
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0057 0.0474 0.0639
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0215 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.5307 0.5306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.3232 0.3231
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0057 0.0474 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0026
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0094 0.0089
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1412 0.141
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0215 0.0209
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0171 0.0169
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0152 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.5902 0.5901
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0005
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0057 0.0474 0.0473
Echinococcus granulosus dnaJ subfamily B 0.0399 0.4424 0.4423
Echinococcus granulosus pyruvate kinase 0.0034 0.0215 0.0213
Onchocerca volvulus 0.0048 0.0369 0.0933
Onchocerca volvulus 0.0229 0.2467 0.9502
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0057 0.0474 0.0473
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0057 0.0474 0.0473
Onchocerca volvulus 0.0054 0.0442 0.1231
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0157 0.0156
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.01 0.0099
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.035 0.2188
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.024 0.2589 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0291 0.0289
Loa Loa (eye worm) hypothetical protein 0.0129 0.1306 0.1301
Loa Loa (eye worm) hypothetical protein 0.0438 0.4875 0.4872
Loa Loa (eye worm) phosphatidylinositol 3 0.0882 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.011 0.1086 0.1085
Brugia malayi RNA binding protein 0.0062 0.0531 0.0531
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0157 0.0156
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.0004
Schistosoma mansoni cpg binding protein 0.0028 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0102
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.4424 0.4423
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0531 0.0529
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0531 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.3232 0.3231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0516 0.0514
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0057 0.0474 0.0473
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2146 0.2142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0474 0.0473
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0081 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1743 0.1742
Brugia malayi Cytochrome P450 family protein 0.0027 0.0132 0.0132
Leishmania major cytochrome p450-like protein 0.0018 0.0028 0.0026
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0057 0.0474 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.1212 0.1211
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0369 0.0364
Toxoplasma gondii hypothetical protein 0.0047 0.0361 0.0486
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0157 0.0156
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0397
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0474 0.0474
Leishmania major cytochrome p450-like protein 0.0018 0.0028 0.0026
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0057 0.0474 0.0473
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0474 0.0474
Echinococcus multilocularis pyruvate kinase 0.0027 0.0131 0.0129
Onchocerca volvulus 0.0093 0.0897 0.3089
Schistosoma mansoni lamin 0.0054 0.0442 0.044
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0057 0.0474 0.0473
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0093 0.0897 0.0897
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.1212 0.7611
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0028 0.0165
Echinococcus granulosus muscleblind protein 0.0438 0.4875 0.4874
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0171 0.0169
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1168 0.733
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0882 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0474 0.0469
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0215 0.0209
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0754 0.0754
Echinococcus multilocularis pyruvate kinase 0.0018 0.0021 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0132 0.0127
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0057 0.0474 0.0473
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0702 0.7925 0.7925
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0215 0.0215
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1032 0.6478
Echinococcus granulosus pyruvate kinase 0.0018 0.0021 0.0019
Schistosoma mansoni intermediate filament proteins 0.0054 0.0442 0.044
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.3187 0.3186
Loa Loa (eye worm) hypothetical protein 0.0054 0.0442 0.0437
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0882 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0028 0.0165
Brugia malayi FAT domain containing protein 0.0129 0.1306 0.1306
Schistosoma mansoni survival motor neuron protein 0.0093 0.0897 0.0895
Echinococcus multilocularis cpg binding protein 0.003 0.0159 0.0157
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0215 0.0209
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0057 0.0474 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.8511 0.8511
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0057 0.0474 0.0473
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0132 0.0131
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3187 0.3186
Brugia malayi CXXC zinc finger family protein 0.0028 0.0141 0.0141
Plasmodium falciparum glutathione reductase 0.0046 0.035 0.7365
Schistosoma mansoni lamin 0.0054 0.0442 0.044
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0882 1 1
Loa Loa (eye worm) cytochrome P450 0.0018 0.0028 0.0023
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.035 0.7365
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0167 0.1743 0.1676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1743 0.1742
Loa Loa (eye worm) hypothetical protein 0.011 0.1086 0.1081
Onchocerca volvulus 0.0081 0.0754 0.2503
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0057 0.0474 0.0639
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0531 0.0529
Schistosoma mansoni hypothetical protein 0.0057 0.0474 0.0473
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1212 0.1211
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0028 0.0165
Trypanosoma cruzi target of rapamycin kinase 3 0.0702 0.7925 0.7925
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0215 0.1338
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0296 0.3232 0.3231
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.3187 0.3186
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0057 0.0474 0.0473
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0057 0.0474 0.0473
Mycobacterium leprae conserved hypothetical protein 0.0057 0.0474 0.3916
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1212 0.7611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.7917 0.7916
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0028 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0028 0.0165
Schistosoma mansoni hypothetical protein 0.0399 0.4424 0.4423
Echinococcus granulosus survival motor neuron protein 1 0.0458 0.5111 0.511
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0167 0.1743 0.1742
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.1212 0.1638
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0021 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.5307 0.5306
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0138 0.0136
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0474 0.0469
Loa Loa (eye worm) hypothetical protein 0.0458 0.5111 0.5109
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0291 0.0289
Brugia malayi Cytochrome P450 family protein 0.0018 0.0028 0.0028
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1592 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0171 0.0169
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0081 1
Echinococcus multilocularis geminin 0.0165 0.172 0.1719
Leishmania major phosphatidylinositol kinase, putative 0.0057 0.0474 0.0473
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0021 0.041
Echinococcus multilocularis survival motor neuron protein 1 0.0458 0.5111 0.511
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0474 0.0469
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0291 0.0289
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0882 1 1
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0215 0.4503
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0141 0.0135
Echinococcus multilocularis pyruvate kinase 0.0018 0.0021 0.0019
Schistosoma mansoni pyruvate kinase 0.0018 0.0021 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.6648 0.6647
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0935 0.0935
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0057 0.0474 1
Schistosoma mansoni cytochrome P450 0.0018 0.0028 0.0026
Echinococcus multilocularis muscleblind protein 0.0438 0.4875 0.4874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.3232 0.3231
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1032 0.881
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1032 0.6478
Schistosoma mansoni hypothetical protein 0.0165 0.172 0.1719
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1212 0.1211
Plasmodium vivax glutathione reductase, putative 0.0046 0.035 0.7365
Echinococcus granulosus tar DNA binding protein 0.0062 0.0531 0.0529
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0296 0.3232 0.3231
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0057 0.0474 0.0473
Echinococcus granulosus neuropeptide s receptor 0.0478 0.5342 0.5342
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0119 0.0117
Plasmodium vivax hypothetical protein 0.0057 0.0474 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.5316 0.5315
Entamoeba histolytica hypothetical protein 0.0057 0.0474 0.0397
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0442 0.0596
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0028 0.0165
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0113
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0754 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.7917 0.7916
Brugia malayi TAR-binding protein 0.0062 0.0531 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.3232 0.3231
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0057 0.0474 0.0397
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0167 0.1743 0.1742
Entamoeba histolytica hypothetical protein 0.0057 0.0474 0.0397
Echinococcus granulosus serine protein kinase ATM 0.0167 0.1743 0.1742
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3187 0.3186
Schistosoma mansoni hypothetical protein 0.0129 0.1306 0.1305
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.035 0.0348
Echinococcus granulosus lamin 0.0054 0.0442 0.044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0935 0.093
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0028 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.01 0.0099
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0005
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0167 0.1743 0.1742
Loa Loa (eye worm) hypothetical protein 0.0025 0.01 0.0095
Schistosoma mansoni hypothetical protein 0.0031 0.0171 0.0169
Toxoplasma gondii thioredoxin reductase 0.0046 0.035 0.0471
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0215 0.0213
Loa Loa (eye worm) hypothetical protein 0.024 0.2589 0.2585
Schistosoma mansoni cpg binding protein 0.003 0.0159 0.0157
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0057 0.0474 0.0469
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0057 0.0474 0.0473
Giardia lamblia Phosphatidylinositol 4-kinase 0.0057 0.0474 0.0473
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0028 0.0165
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0474 0.0474
Echinococcus granulosus lamin dm0 0.0054 0.0442 0.044
Leishmania major hypothetical protein, unknown function 0.0057 0.0474 0.0473
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0057 0.0474 0.0473
Echinococcus granulosus cpg binding protein 0.003 0.0159 0.0157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0171 0.0169
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0366 0.4047 0.4046
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0028 0.0165
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0057 0.0474 0.0474
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0057 0.0474 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0004
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0531 0.0531
Leishmania major pyruvate kinase 0.0034 0.0215 0.0213
Giardia lamblia Pyruvate kinase 0.0018 0.0021 0.0019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1168 0.733
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0028 0.0165
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.1212 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.7917 0.7916
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1032 0.6478
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0081 0.0496
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.01 0.0099
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0057 0.0474 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0057 0.0474 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Onchocerca volvulus Huntingtin homolog 0.024 0.2589 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0021 0.0019
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0005 0.0023
Echinococcus multilocularis tumor protein p63 0.0326 0.3587 0.3586
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0442 0.0437
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0057 0.0474 0.0473
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0296 0.3232 0.3232
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0531 0.0529
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0028 0.0165
Toxoplasma gondii FATC domain-containing protein 0.0167 0.1743 0.2357
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0094 0.0014
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0882 1 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0754 0.0752
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0057 0.0474 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.5841 0.5841
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0004
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0028 0.0026
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1412 0.141
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0474 0.2971
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0167 0.1743 0.1743
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2467 0.2466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.5902 0.5901
Leishmania major pyruvate kinase 0.0034 0.0215 0.0213
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0215 0.0215
Leishmania major trypanothione reductase 0.0046 0.035 0.0348
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0081 0.3704
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0581 0.0581
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0057 0.0474 0.0473
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0132 0.0127
Loa Loa (eye worm) hypothetical protein 0.018 0.1892 0.1888
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0296 0.3232 0.3231
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0882 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0057 0.0474 0.0473
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0397
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0397
Brugia malayi glutathione reductase 0.0046 0.035 0.035
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0296 0.3232 0.3231
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0215 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0882 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0296 0.3232 0.3231
Brugia malayi hypothetical protein 0.0458 0.5111 0.5111
Loa Loa (eye worm) hypothetical protein 0.0081 0.0754 0.0749
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0057 0.0474 0.0639
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0057 0.0474 0.0473
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0215 0.0213
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1032 0.6478
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0057 0.0474 0.0473
Entamoeba histolytica protein kinase rad3, putative 0.0167 0.1743 0.1676
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0057 0.0474 0.0473
Leishmania major phosphatidylinositol 4-kinase, putative 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0028 0.0165
Echinococcus multilocularis 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0028 0.0165
Echinococcus granulosus tumor protein p63 0.0326 0.3587 0.3586
Loa Loa (eye worm) hypothetical protein 0.0031 0.0171 0.0166
Echinococcus granulosus intermediate filament protein 0.0054 0.0442 0.044
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0028 0.0026
Brugia malayi Muscleblind-like protein 0.0438 0.4875 0.4875
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0157 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0474 0.0473
Schistosoma mansoni hypothetical protein 0.0031 0.0171 0.0169
Loa Loa (eye worm) hypothetical protein 0.0053 0.0431 0.0426
Loa Loa (eye worm) hypothetical protein 0.0057 0.0474 0.0469
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0296 0.3232 0.3231
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0474 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0057 0.0474 0.0473
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0215 0.0213
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0057 0.0474 0.0473
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0474 0.0469
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0028 0.0026
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0296 0.3232 0.3231
Loa Loa (eye worm) hypothetical protein 0.0186 0.1963 0.1959
Entamoeba histolytica hypothetical protein 0.0057 0.0474 0.0397
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0028 0.0165
Entamoeba histolytica hypothetical protein 0.0167 0.1743 0.1676
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0296 0.3232 0.3231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.5841 0.5841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Brugia malayi Pre-SET motif family protein 0.0202 0.2146 0.2146
Leishmania major phosphatidylinositol kinase related protein, putative 0.0057 0.0474 0.0473
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0702 0.7925 0.7925
Echinococcus granulosus pyruvate kinase 0.0034 0.0215 0.0213
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1168 0.733
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0028 0.0035
Plasmodium vivax SET domain protein, putative 0.0029 0.0157 0.3293
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0129 0.1306 0.1305
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0028 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1212 0.7611
Echinococcus multilocularis pyruvate kinase 0.0034 0.0215 0.0213
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0057 0.0474 0.0473
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.8949 0.8949
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0021 0.041
Trichomonas vaginalis conserved hypothetical protein 0.011 0.1086 0.1085
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0028 0.0165
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0442 0.0437
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0935 0.0935
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0167 0.1743 0.1743
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0057 0.0474 0.0639
Schistosoma mansoni cpg binding protein 0.003 0.0159 0.0157
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0028 0.0165
Loa Loa (eye worm) hypothetical protein 0.0097 0.0935 0.093
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0057 0.0474 0.0639
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0081 0.1668
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0882 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0215 0.0302
Plasmodium falciparum thioredoxin reductase 0.0046 0.035 0.7365
Onchocerca volvulus 0.0029 0.0157 0.0068
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0171 0.0171
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0057 0.0474 0.0473
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0215 0.0302
Brugia malayi Cytochrome P450 family protein 0.0058 0.0482 0.0482
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0028 0.0165
Echinococcus multilocularis musashi 0.0054 0.0442 0.044
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0057 0.0474 0.0473
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.01 0.2086
Brugia malayi follicle stimulating hormone receptor 0.0228 0.2454 0.2454
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.1306 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0882 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0417 0.4633 0.4632
Schistosoma mansoni pyruvate kinase 0.0034 0.0215 0.0213
Loa Loa (eye worm) glutathione reductase 0.0046 0.035 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0157 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0028 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.5316 0.5315
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0057 0.0474 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.01 0.2086
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1412 0.141
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0028 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0028 0.0165
Echinococcus multilocularis 0.0018 0.0028 0.0026
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0296 0.3232 0.3231
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.035 0.0348
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.2454 0.245
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0397
Echinococcus multilocularis lamin 0.0054 0.0442 0.044
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0028 0.0165
Loa Loa (eye worm) hypothetical protein 0.0029 0.0157 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.5316 0.5315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.6428 0.6427
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0005 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0395 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.5307 0.5306
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0129 0.1306 0.1305
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0028 0.0165
Brugia malayi Cytochrome P450 family protein 0.0027 0.0132 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0028 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0531 0.0529
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0474 0.0469
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0057 0.0474 0.0473
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0291 0.0289
Chlamydia trachomatis pyruvate kinase 0.0034 0.0215 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0057 0.0474 0.0473
Giardia lamblia Pyruvate kinase 0.0034 0.0215 0.0213
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0081 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0028 0.0165
Onchocerca volvulus 0.0054 0.0442 0.1231
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0081 0.0462
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0081 0.0079
Giardia lamblia Hypothetical protein 0.0057 0.0474 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0882 1 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0028 0.0165
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0081 0.0496
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0057 0.0474 0.0473
Loa Loa (eye worm) phosphatidylinositol kinase 0.0057 0.0474 0.0469
Leishmania major hypothetical protein, conserved 0.0025 0.01 0.0099
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0028 0.0165
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0474 0.0474
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.035 0.0348
Schistosoma mansoni hypothetical protein 0.0066 0.0581 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0581 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.7917 0.7916
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1743 0.1742
Mycobacterium tuberculosis Probable reductase 0.0105 0.1032 0.6478
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0473
Onchocerca volvulus 0.0057 0.0474 0.1362
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0005 0.0004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0057 0.0474 0.0473
Brugia malayi Pre-SET motif family protein 0.0029 0.0157 0.0157
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0215 0.0288
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0473
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0167 0.1743 0.1742
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0882 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0057 0.0474 0.0473
Leishmania major phosphatidylinositol 3-kinase, putative 0.0057 0.0474 0.0473
Brugia malayi cytochrome P450 0.0018 0.0028 0.0028
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0057 0.0474 0.0473
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0119 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.5902 0.5901
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0005 0.0077
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0882 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0132 0.0821
Echinococcus multilocularis pyruvate kinase 0.0034 0.0215 0.0213
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0028 0.0165
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.01 0.0133
Echinococcus granulosus geminin 0.0165 0.172 0.1719
Giardia lamblia GTOR 0.0882 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0157 0.0156
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0057 0.0474 0.0473
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0157 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0028 0.0165
Echinococcus multilocularis Zinc finger, PHD finger 0.0057 0.0474 0.0473
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.1212 0.1211
Echinococcus multilocularis GPCR, family 2 0.0031 0.0171 0.0169
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0474 0.0474
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1168 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0057 0.0474 0.0473
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0057 0.0474 0.0397
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0369 0.0367
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0028 0.0165
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0754 0.0752
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0005 0.0077
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0882 1 1
Leishmania major cytochrome p450-like protein 0.0027 0.0132 0.0131
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0057 0.0474 0.0473
Loa Loa (eye worm) hypothetical protein 0.0438 0.4875 0.4872
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0004
Mycobacterium ulcerans hypothetical protein 0.0154 0.1592 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0215 0.0302
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0081 0.0107
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0028 0.0165
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0152 0.0152
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0028 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.7917 0.7916
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1212 0.7611
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0167 0.1743 0.1742
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0057 0.0474 0.0473
Echinococcus multilocularis lamin dm0 0.0054 0.0442 0.044
Echinococcus multilocularis muscleblind protein 1 0.0438 0.4875 0.4874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.3232 0.3231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.5316 0.5315
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.5342 0.5342
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0531 0.0526
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0057 0.0474 0.0473
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0057 0.0474 0.0473
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0132 0.0127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0171 0.0166
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.01 0.2086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.1963 0.1962
Entamoeba histolytica hypothetical protein 0.0057 0.0474 0.0397
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0057 0.0474 0.0473
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0057 0.0474 0.0473
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0057 0.0474 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0028 0.0165
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0081 0.1668
Brugia malayi Thioredoxin reductase 0.0046 0.035 0.035
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0057 0.0474 0.0473
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0215 0.1338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0157 0.0156
Loa Loa (eye worm) phosphatidylinositol 3 0.0296 0.3232 0.3228
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0028 0.0165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1032 0.6478
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0102
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0167 0.1743 0.1742
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0057 0.0474 0.0473
Loa Loa (eye worm) hypothetical protein 0.0167 0.1743 0.1739
Schistosoma mansoni pyruvate kinase 0.0034 0.0215 0.0213
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0882 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.7391 0.739
Echinococcus multilocularis pyruvate kinase 0.0018 0.0021 0.0019
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0028 0.0165
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0057 0.0474 0.0469
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0531 0.0526
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0028 0.0026
Trypanosoma brucei trypanothione reductase 0.0046 0.035 0.0348
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0004
Plasmodium falciparum pyruvate kinase 0.0034 0.0215 0.4503
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0028 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0028 0.0165
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0081 0.0079
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0482 0.0477
Schistosoma mansoni hypothetical protein 0.0031 0.0171 0.0169
Brugia malayi hypothetical protein 0.024 0.2589 0.2589
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0215 0.0213
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0081 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0531 0.0529
Schistosoma mansoni hypothetical protein 0.0093 0.0897 0.0895
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0215 0.1637
Onchocerca volvulus 0.0057 0.0474 0.1362
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0028 0.0165
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.035 0.0345
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0215 0.0213

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.