Detailed information for compound 723927

Basic information

Technical information
  • TDR Targets ID: 723927
  • Name: N-(2-ethoxyphenyl)-1-(2-methoxyphenyl)-5-oxop yrrolidine-3-carboxamide
  • MW: 354.4 | Formula: C20H22N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)C1CC(=O)N(C1)c1ccccc1OC
  • InChi: 1S/C20H22N2O4/c1-3-26-17-10-6-4-8-15(17)21-20(24)14-12-19(23)22(13-14)16-9-5-7-11-18(16)25-2/h4-11,14H,3,12-13H2,1-2H3,(H,21,24)
  • InChiKey: RPHOWQVJROSLAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethoxyphenyl)-1-(2-methoxyphenyl)-5-oxo-pyrrolidine-3-carboxamide
  • N-(2-ethoxyphenyl)-1-(2-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxamide
  • N-(2-ethoxyphenyl)-5-keto-1-(2-methoxyphenyl)pyrrolidine-3-carboxamide
  • AK-918/42815139
  • STK265111

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0139
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0056 0.0181
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0031 0.0031
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0031 0.0031
Onchocerca volvulus Matrilysin homolog 0.0027 0.024 0.0754
Mycobacterium tuberculosis Conserved protein 0.0069 0.0773 0.1404
Schistosoma mansoni hypothetical protein 0.0013 0.0056 0.0072
Onchocerca volvulus 0.0011 0.003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0139
Onchocerca volvulus Matrilysin homolog 0.0012 0.005 0.0112
Schistosoma mansoni hypothetical protein 0.0395 0.4932 0.6344
Mycobacterium leprae ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.0077 0.0878 0.4164
Schistosoma mansoni pol-related 0.0011 0.003 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0003
Schistosoma mansoni patched 1 0.0041 0.0421 0.0541
Entamoeba histolytica alcohol dehydrogenase, putative 0.0011 0.003 0.0118
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl pentapeptide synthase 0.0077 0.0878 0.3606
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramoylalanine-D-glutamate ligase 0.0199 0.2434 1
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0026 0.0221 0.074
Echinococcus granulosus microtubule associated protein 2 0.0618 0.7774 1
Giardia lamblia Tenascin precursor 0.0018 0.0125 0.9687
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0003
Echinococcus multilocularis fibrillin 2 0.0018 0.0125 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0219 0.9919
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1121 0.1569
Brugia malayi EGF-like domain containing protein 0.0018 0.0125 0.0154
Echinococcus multilocularis muscleblind protein 1 0.0172 0.2089 0.2089
Giardia lamblia hypothetical protein 0.0018 0.0125 0.9687
Toxoplasma gondii ABC1 family protein 0.0069 0.0773 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0056 0.0181
Brugia malayi ecdysteroid receptor 0.001 0.0019 0.0003
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0018 0.0125 0.042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0103 0.0187
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0026 0.0221 0.269
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.004 0.0051
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0011 0.003 0.0101
Entamoeba histolytica aldose reductase, putative 0.0011 0.003 0.0118
Toxoplasma gondii aldo-keto reductase 0.0011 0.003 0.0172
Mycobacterium tuberculosis Probable hydrolase 0.0069 0.0773 0.1404
Brugia malayi Matrixin family protein 0.0012 0.005 0.0048
Schistosoma mansoni topbp1 0.001 0.0017 0.0022
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.0024
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0031 0.004
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl tripeptide synthase 0.0077 0.0878 0.3606
Onchocerca volvulus 0.0031 0.029 0.0921
Schistosoma mansoni hypothetical protein 0.0011 0.0031 0.004
Onchocerca volvulus 0.0012 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0051 0.0539 0.0742
Loa Loa (eye worm) hypothetical protein 0.0069 0.0773 0.1074
Onchocerca volvulus 0.0047 0.0488 0.159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0003
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Echinococcus granulosus fibrillin 1 0.0018 0.0125 0.0161
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0345
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0019 0.0003
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase 0.0077 0.0878 0.2839
Brugia malayi Kelch motif family protein 0.0085 0.0983 0.1372
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0056 0.0102
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0017 0.0001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0069 0.0773 0.1404
Brugia malayi steroid hormone receptor 0.001 0.0019 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.029 0.0388
Echinococcus granulosus fibrillin 2 0.0018 0.0125 0.0161
Toxoplasma gondii aldose reductase, putative 0.0011 0.003 0.0172
Brugia malayi cytochrome P450 0.0013 0.0056 0.0056
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0219 0.2668
Echinococcus granulosus beta LACTamase domain containing family member 0.0069 0.0773 0.0995
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0011 0.003 0.0101
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0115 0.0209
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0031 0.002
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.0024
Echinococcus multilocularis integrin beta 2 0.0416 0.5201 0.5201
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0019 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0003
Schistosoma mansoni cpg binding protein 0.0028 0.0248 0.0319
Echinococcus granulosus lamin 0.0029 0.0265 0.0341
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0077 0.0878 0.2839
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0031 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0129 0.0129
Leishmania major cytochrome p450-like protein 0.0013 0.0056 0.0349
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0056 0.0181
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2981 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Onchocerca volvulus 0.0011 0.003 0.0044
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0056 0.0181
Loa Loa (eye worm) hypothetical protein 0.0029 0.0265 0.0352
Schistosoma mansoni lamin 0.0029 0.0265 0.0341
Brugia malayi Hemopexin family protein 0.0017 0.0116 0.014
Schistosoma mansoni topbp1 0.001 0.0017 0.0022
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0017 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0056 0.0102
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0017 0.0055
Echinococcus multilocularis 0.0013 0.0056 0.0056
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Echinococcus multilocularis aldo keto reductase 0.0011 0.003 0.003
Onchocerca volvulus 0.0028 0.0248 0.0779
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0031 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0773 0.2595
Loa Loa (eye worm) hypothetical protein 0.0029 0.0258 0.0343
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0019 0.0024
Brugia malayi beta-lactamase family protein 0.0069 0.0773 0.1075
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.019 0.2149
Loa Loa (eye worm) histone methyltransferase 0.001 0.0018 0.0001
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0026 0.0221 0.0221
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0019 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0099 0.0117
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.019 0.1565
Onchocerca volvulus 0.0029 0.0265 0.0837
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Plasmodium vivax SET domain protein, putative 0.0031 0.029 0.361
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Onchocerca volvulus 0.0242 0.2981 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0488 0.067
Mycobacterium ulcerans oxidoreductase 0.0011 0.003 0.0097
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0077 0.0878 0.4164
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.019 0.2149
Brugia malayi AMP-binding enzyme family protein 0.0023 0.019 0.0246
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0031 0.004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Onchocerca volvulus 0.0011 0.0029 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0003
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0056 0.0181
Trypanosoma brucei aldo/keto reductase, putative 0.0011 0.003 0.0172
Echinococcus multilocularis lamin 0.0029 0.0265 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0492 0.0674
Echinococcus multilocularis adam 0.0018 0.0125 0.0125
Echinococcus granulosus aldo keto reductase 0.0011 0.003 0.0039
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0128
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Mycobacterium tuberculosis Conserved protein 0.0069 0.0773 0.1404
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0017 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1648 0.212
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0156 0.0505
Onchocerca volvulus 0.0011 0.003 0.0044
Echinococcus multilocularis lamin dm0 0.0029 0.0265 0.0265
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0019 0.0019
Echinococcus multilocularis fibrillin 1 0.0018 0.0125 0.0125
Echinococcus granulosus replication factor c subunit 1 0.001 0.0017 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0773 0.2595
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0129 0.0529
Brugia malayi transcription factor E74 isoform 0.0011 0.0031 0.002
Onchocerca volvulus 0.001 0.0019 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0128
Plasmodium falciparum aldo-keto reductase, putative 0.0011 0.003 0.0639
Echinococcus granulosus nibrin 0.001 0.0017 0.0022
Schistosoma mansoni ets 0.0011 0.0031 0.004
Schistosoma mansoni hypothetical protein 0.0047 0.0488 0.0628
Onchocerca volvulus 0.0023 0.019 0.0583
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.019 0.0614
Loa Loa (eye worm) matrixin family protein 0.0027 0.024 0.0317
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0003
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0011 0.003 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0542 0.0747
Leishmania major cytochrome p450-like protein 0.0021 0.0156 0.1695
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0773 0.2595
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0056 0.0181
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0017 0.0000031374
Trichomonas vaginalis aldo/keto reductase, putative 0.0011 0.003 0.0101
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0019 0.0003
Mycobacterium leprae possible ligase 0.0026 0.0221 0.1046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0337 0.0455
Brugia malayi FolC bifunctional protein 0.0026 0.0221 0.029
Brugia malayi nuclear receptor NHR-88 0.001 0.0019 0.0003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1121 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0056 0.0181
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0268 0.0345
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0773 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.0746
Mycobacterium tuberculosis Conserved protein 0.0011 0.003 0.0055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0129 0.1476
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0031 0.002
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Schistosoma mansoni hypothetical protein 0.004 0.0402 0.0517
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.029 0.0373
Brugia malayi hypothetical protein 0.001 0.0017 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2607 0.3679
Echinococcus granulosus cpg binding protein 0.0029 0.0268 0.0345
Onchocerca volvulus 0.0069 0.0773 0.2552
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0093 0.0108
Brugia malayi Matrixin family protein 0.0012 0.005 0.0048
Mycobacterium ulcerans lipase LipD 0.0069 0.0773 0.2502
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0019 0.0024
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0056 0.0181
Loa Loa (eye worm) matrix metalloproteinase 0.0012 0.005 0.0047
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0069 0.0773 0.1074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0024
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0056 0.0102
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0019 0.0024
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0015 0.0084 0.0153
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0024
Mycobacterium leprae putative cytochrome p450 0.0013 0.0056 0.0266
Brugia malayi EGF-like domain containing protein 0.0018 0.0125 0.0154
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0056 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0129 0.1476
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0017 0.0057
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0056 0.0181
Mycobacterium ulcerans UDP-N-acetylmuramyl tripeptide synthase 0.0026 0.0221 0.0714
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0115 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0023 0.019 0.0246
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0265 0.0352
Brugia malayi Cytochrome P450 family protein 0.0021 0.0156 0.0198
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0056 0.0181
Mycobacterium ulcerans hypothetical protein 0.0069 0.0773 0.2502
Giardia lamblia Aldose reductase 0.0011 0.003 0.1165
Echinococcus multilocularis musashi 0.0029 0.0265 0.0265
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0128
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0099 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0212 0.2602 0.3671
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0012 0.005 0.0065
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.029 0.029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.029 0.0373
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Brugia malayi intermediate filament protein 0.0029 0.0265 0.0353
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.019 0.0614
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0248 0.0328
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0115 0.0319
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.029 0.029
Echinococcus multilocularis aldo keto reductase 0.0011 0.003 0.003
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0056 0.0515
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0103 0.0187
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0023 0.019 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0003
Brugia malayi Matrixin family protein 0.0012 0.005 0.0048
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0056 0.0181
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0156 0.1838
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0056 0.0102
Toxoplasma gondii hypothetical protein 0.0018 0.0125 0.143
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Giardia lamblia Aldose reductase 0.0011 0.003 0.1165
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.019 0.2149
Brugia malayi hypothetical protein 0.0085 0.0983 0.1372
Echinococcus multilocularis ets variant gene 4 0.0011 0.0031 0.0031
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0115 0.1297
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0056 0.0102
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0056 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0154
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0129 0.0234
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.019 0.0344
Mycobacterium leprae conserved hypothetical protein 0.0069 0.0773 0.367
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0129 0.1476
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0069 0.0773 0.2502
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0773 0.2595
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0219 0.2669
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0172 0.2089 0.2943
Loa Loa (eye worm) hypothetical protein 0.0069 0.0773 0.1074
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Brugia malayi Ets-domain containing protein 0.0074 0.0836 0.1163
Mycobacterium leprae Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD 0.0174 0.2108 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0983 0.1372
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0056 0.0181
Mycobacterium ulcerans beta-lactamase 0.0069 0.0773 0.2502
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0129 0.1476
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0421 0.0574
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0017 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0156 0.0197
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0026 0.0221 0.269
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) 0.0077 0.0878 0.2839
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0156 0.0197
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0056 0.0181
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0019 0.0019
Loa Loa (eye worm) oxidoreductase 0.0011 0.003 0.0018
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0044 0.0462 0.0462
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0011 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0096 0.1121 0.1568
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0129 0.0416
Plasmodium falciparum aldehyde reductase, putative 0.0011 0.003 0.0639
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0085 0.0983 0.1372
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0156 0.0197
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0421 0.0541
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Chlamydia trachomatis UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminoligase 0.0077 0.0878 0.2799
Onchocerca volvulus 0.0011 0.003 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Schistosoma mansoni survival motor neuron protein 0.0047 0.0488 0.0628
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.0245
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0129 1
Schistosoma mansoni ets-related 0.0224 0.2752 0.354
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.019 0.0901
Echinococcus granulosus aldo keto reductase 0.0011 0.003 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.0402 0.0517
Treponema pallidum DNA ligase (lig) 0.001 0.0017 0.0055
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0836 0.1163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0099 0.0117
Echinococcus granulosus muscleblind protein 0.0172 0.2089 0.2687
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Schistosoma mansoni ap endonuclease 0.0018 0.0129 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.019 0.0901
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.004 0.0402 0.0517
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0265 0.0352
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0129 0.1327
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0056 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0057
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0069 0.0773 0.1404
Brugia malayi nuclear hormone receptor 0.001 0.0019 0.0003
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0026 0.0221 0.0284
Trypanosoma cruzi aldo/keto reductase, putative 0.0011 0.003 0.0172
Entamoeba histolytica aldose reductase, putative 0.0011 0.003 0.0118
Brugia malayi Cytochrome P450 family protein 0.0047 0.0492 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0003
Echinococcus multilocularis aldo keto reductase 0.0011 0.003 0.003
Schistosoma mansoni folylpolyglutamate synthase 0.0026 0.0221 0.0284
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0019 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.019 0.0614
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0019 0.0003
Chlamydia trachomatis UDP-N-acetylmuramoylalanine--D-glutamate ligase 0.0251 0.3091 1
Echinococcus multilocularis aldo keto reductase 0.0011 0.003 0.003
Brugia malayi CHE-14 protein 0.0041 0.0421 0.0574
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0129 0.1011
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0017 0.0017
Loa Loa (eye worm) oxidoreductase 0.0011 0.003 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0219 0.2669
Toxoplasma gondii exonuclease III APE 0.0018 0.0129 0.1476
Schistosoma mansoni cytochrome P450 0.0013 0.0056 0.0072
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0093 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0019 0.0003
Brugia malayi Matrixin family protein 0.0012 0.005 0.0048
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0011 0.003 0.0019
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0056 0.0181
Entamoeba histolytica alcohol dehydrogenase, putative 0.0011 0.003 0.0118
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4932 0.6344
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0019 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0542 0.0746
Echinococcus granulosus GPCR family 2 0.0016 0.0099 0.0128
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0128
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0031 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0056 0.0102
Chlamydia trachomatis UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 0.0077 0.0878 0.2799
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0019 0.0003
Trypanosoma brucei prostaglandin f synthase 0.0011 0.003 0.0172
Brugia malayi DKFZp564C0469 protein 0.001 0.0017 0.0001
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0056 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0019 0.0024
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0056 0.0515
Onchocerca volvulus 0.0017 0.0116 0.0332
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.114 0.1467
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0011 0.003 0.0101
Brugia malayi follicle stimulating hormone receptor 0.0212 0.2602 0.3672
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0056 0.0102
Echinococcus granulosus protein C ets 2 0.0011 0.0031 0.004
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0026 0.0221 0.0687
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0019 0.0006
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0011 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0069 0.0773 0.1074
Leishmania major hypothetical protein, conserved 0.0069 0.0773 1
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0773 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0773 0.0995
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0056 0.0102
Giardia lamblia Neurogenic locus notch-like protein 0.0018 0.0125 0.9687
Giardia lamblia Neurogenic locus Notch protein precursor 0.0018 0.0125 0.9687
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0128
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0015 0.0084 0.0096
Schistosoma mansoni nuclear hormone receptor 0.001 0.0019 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0056 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0003
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0056 0.0181
Brugia malayi EGF-like domain containing protein 0.0018 0.0125 0.0154
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0026 0.0221 1
Schistosoma mansoni hypothetical protein 0.0011 0.0031 0.004
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0011 0.003 0.0019
Onchocerca volvulus Matrix metalloproteinase homolog 0.0027 0.024 0.0754
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0017 0.0001
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Trichomonas vaginalis aldo/keto reductase, putative 0.0011 0.003 0.0101
Schistosoma mansoni hypothetical protein 0.0011 0.004 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0057
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Trypanosoma cruzi aldo/keto reductase, putative 0.0011 0.003 0.0172
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0056 0.0102
Brugia malayi hypothetical protein 0.0016 0.0104 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0154
Brugia malayi topoisomerase 0.001 0.0017 0.0001
Loa Loa (eye worm) beta-lactamase 0.0069 0.0773 0.1074
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0011 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0069 0.0773 0.1074
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.019 0.0614
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1121 0.1442
Echinococcus granulosus geminin 0.0325 0.4032 0.5186
Echinococcus multilocularis protein C ets 2 0.0011 0.0031 0.0031
Trypanosoma brucei aldo-keto reductase, putative 0.0011 0.003 0.0172
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0156 0.1838
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.0773 1
Mycobacterium ulcerans UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 0.0251 0.3091 1
Schistosoma mansoni hypothetical protein 0.0325 0.4032 0.5186
Brugia malayi hypothetical protein 0.0025 0.0219 0.0287
Trypanosoma cruzi folylpolyglutamate synthetase 0.0026 0.0221 0.269
Echinococcus multilocularis GPCR, family 2 0.0016 0.0099 0.0099
Schistosoma mansoni intermediate filament proteins 0.0029 0.0265 0.0341
Schistosoma mansoni ets-related 0.0011 0.0031 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0154
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0019 0.0019
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0056 0.0181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0019 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0019 0.0019
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0056 0.0072
Schistosoma mansoni microtubule-associated protein tau 0.0618 0.7774 1
Echinococcus granulosus expressed conserved protein 0.009 0.1047 0.1347
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0056 0.0515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0019 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0056 0.0515
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0077 0.0878 0.1592
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0024
Giardia lamblia Tenascin-37 0.0018 0.0125 0.9687
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.019 0.0614
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0542 0.0747
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0056 0.0102
Mycobacterium tuberculosis Probable lipase LipE 0.0069 0.0773 0.1404
Loa Loa (eye worm) hypothetical protein 0.0172 0.2089 0.2943
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0099 0.0117
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Onchocerca volvulus 0.0069 0.0773 0.2552
Echinococcus multilocularis cpg binding protein 0.0029 0.0268 0.0268
Onchocerca volvulus 0.0018 0.0125 0.0365
Entamoeba histolytica aldose reductase, putative 0.0011 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0154
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0026 0.0221 0.0221
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.019 0.0344
Brugia malayi Muscleblind-like protein 0.0172 0.2089 0.2943
Brugia malayi hypothetical protein 0.001 0.0017 0.0001
Brugia malayi Ets-domain containing protein 0.0074 0.0836 0.1163
Brugia malayi Pre-SET motif family protein 0.0031 0.029 0.0388
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.003 0.0055
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4932 0.4932
Treponema pallidum UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD) 0.0251 0.3091 1
Mycobacterium tuberculosis Probable esterase LipL 0.0069 0.0773 0.1404
Echinococcus multilocularis nibrin 0.001 0.0017 0.0017
Mycobacterium tuberculosis Probable lipase LipD 0.0069 0.0773 0.1404
Echinococcus multilocularis protein jagged 2 0.0018 0.0125 0.0125
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0421 0.0541
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.0245
Loa Loa (eye worm) FolC protein 0.0026 0.0221 0.0289
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramate-alanine ligase 0.0077 0.0878 0.3606
Echinococcus multilocularis muscleblind protein 0.0172 0.2089 0.2089
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.0077 0.0878 0.2839
Schistosoma mansoni elf1 0.0011 0.0031 0.004
Onchocerca volvulus 0.0029 0.0265 0.0837
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0069 0.0773 0.1404
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.019 0.0614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.029 0.0373
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.008
Trichomonas vaginalis hypothetical protein 0.0018 0.0125 0.042
Loa Loa (eye worm) fli-1 protein 0.0224 0.2752 0.3884
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0024
Brugia malayi NADH-dependent xylose reductase 0.0011 0.003 0.0019
Leishmania major folylpolyglutamate synthetase 0.0026 0.0221 0.2563
Echinococcus granulosus integrin beta 2 0.0416 0.5201 0.669
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0156 0.1838
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.019 0.0614
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0129 0.0416
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0265 0.0353
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0579 0.7426
Schistosoma mansoni DNA ligase IV 0.001 0.0017 0.0022
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0031 0.002
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0026 0.0221 0.269
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0056 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0287
Loa Loa (eye worm) cytochrome P450 0.0013 0.0056 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0421 0.1412
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0129 0.0432
Giardia lamblia Tenascin-X 0.0018 0.0125 0.9687
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0069 0.0773 0.1074
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.019 0.1565
Echinococcus granulosus hypothetical protein 0.0011 0.003 0.0039
Brugia malayi hypothetical protein 0.0228 0.2807 0.3962
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0073 0.0094
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1121 0.1121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0003
Trichomonas vaginalis aldo/keto reductase, putative 0.0011 0.003 0.0101
Loa Loa (eye worm) oxidoreductase 0.0011 0.003 0.0018
Echinococcus multilocularis microtubule associated protein 2 0.0618 0.7774 0.7774
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0056 0.0266
Echinococcus granulosus intermediate filament protein 0.0029 0.0265 0.0341
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0019
Brugia malayi Cytochrome P450 family protein 0.0013 0.0056 0.0056
Echinococcus granulosus voltage gated potassium channel subunit 0.0011 0.003 0.0039
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0836 0.0836
Brugia malayi Ets-domain containing protein 0.0011 0.0031 0.002
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0056 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.029 0.361
Schistosoma mansoni aldo-keto reductase 0.0011 0.003 0.0039
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0056 0.0181
Schistosoma mansoni coup transcription factor 0.001 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.007
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0011 0.003 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0129 0.0166
Schistosoma mansoni hypothetical protein 0.004 0.0402 0.0517
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) 0.0077 0.0878 0.2839
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0044 0.0462 0.0594
Mycobacterium ulcerans UDP-N-acetylmuramate--L-alanine ligase 0.0077 0.0878 0.2839
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.029 0.0373
Plasmodium vivax aldehyde reductase, putative 0.0011 0.003 0.0172
Schistosoma mansoni hypothetical protein 0.0325 0.4032 0.5186
Echinococcus multilocularis protein dispatched 1 0.0047 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0031 0.004
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0031 0.002
Onchocerca volvulus 0.0011 0.003 0.0044
Trypanosoma cruzi aldo-keto reductase 0.0011 0.003 0.0172
Mycobacterium ulcerans hypothetical protein 0.0023 0.019 0.0614
Brugia malayi beta-lactamase family protein 0.0069 0.0773 0.1075
Echinococcus multilocularis voltage gated potassium channel subunit 0.0011 0.003 0.003
Loa Loa (eye worm) integrin beta-2 0.0562 0.7058 1
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0031 0.0031
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0056 0.0349
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0017 0.0022
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0056 0.0181
Leishmania major hypothetical protein, conserved 0.0025 0.0219 0.254
Mycobacterium ulcerans esterase/lipase LipP 0.0069 0.0773 0.2502
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0017 0.0000045802
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0017 0.007
Brugia malayi Cytochrome P450 family protein 0.0021 0.0156 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.029 0.0373
Onchocerca volvulus 0.0069 0.0773 0.2552
Loa Loa (eye worm) hypothetical protein 0.0063 0.0699 0.0969
Giardia lamblia High cysteine protein 0.0018 0.0125 0.9687
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0019 0.0024
Schistosoma mansoni hypothetical protein 0.0017 0.0116 0.0149
Trichomonas vaginalis esterase, putative 0.0069 0.0773 0.2595
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0011 0.003 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0219 0.2669
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0219 0.9919
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0129 0.0159
Echinococcus granulosus lamin dm0 0.0029 0.0265 0.0341
Schistosoma mansoni lamin 0.0029 0.0265 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.003 0.0101
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0337 0.0455
Loa Loa (eye worm) matrixin family protein 0.003 0.0272 0.0362
Mycobacterium ulcerans hypothetical protein 0.0011 0.003 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0019 0.0024
Mycobacterium leprae Probable lipase LipE 0.0069 0.0773 0.367
Echinococcus multilocularis protein patched 0.0041 0.0421 0.0421
Schistosoma mansoni ap endonuclease 0.0018 0.0129 0.0166
Loa Loa (eye worm) hypothetical protein 0.0069 0.0773 0.1074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.019 0.1565
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0345
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0056 0.0102
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0115 0.4819
Brugia malayi beta-lactamase 0.0069 0.0773 0.1075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0773 0.0995
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1648 0.1648
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0069 0.0773 0.1075
Loa Loa (eye worm) hypothetical protein 0.0228 0.2807 0.3962
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0129 0.5488
Schistosoma mansoni gabp alpha 0.0074 0.0836 0.1075
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0836 0.1075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0103 0.0187
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0099
Schistosoma mansoni integrin beta subunit 0.0331 0.4113 0.529
Echinococcus granulosus adam 0.0018 0.0125 0.0161
Echinococcus multilocularis beta LACTamase domain containing family member 0.0069 0.0773 0.0773
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0056 0.0515
Loa Loa (eye worm) oxidoreductase 0.0011 0.003 0.0018
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0026 0.0221 0.0284
Schistosoma mansoni hypothetical protein 0.0035 0.0337 0.0434
Leishmania major cytochrome p450-like protein 0.0013 0.0056 0.0349
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0011 0.003 0.0039
Brugia malayi CXXC zinc finger family protein 0.0028 0.0248 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0139
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0019 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0421 0.0421
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0219 0.2669
Echinococcus granulosus FTZ F1 alpha 0.001 0.0019 0.0024
Loa Loa (eye worm) oxidoreductase 0.0011 0.003 0.0018
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0031 0.0031
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0031 0.0031
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0011 0.003 0.0101
Brugia malayi Pre-SET motif family protein 0.0213 0.2607 0.3679
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.0245
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0056 0.0102
Echinococcus multilocularis expressed conserved protein 0.009 0.1047 0.1047
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0056 0.0181
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0011 0.003 0.0039
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0017 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0421 0.0574
Schistosoma mansoni potassium channel beta 0.0011 0.003 0.0039
Brugia malayi Fli-1 protein 0.0224 0.2752 0.3885
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.0077 0.0878 0.1592
Giardia lamblia High cysteine protein 0.0018 0.0125 0.9687
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0129 0.0432
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0011 0.003 0.0143
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0031 0.004
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0026 0.0221 0.269
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0011 0.003 0.0019
Echinococcus multilocularis geminin 0.0325 0.4032 0.4032
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0057
Brugia malayi EGF-like domain containing protein 0.0018 0.0125 0.0154
Mycobacterium leprae Possible oxidoreductase 0.0011 0.003 0.0143
Onchocerca volvulus 0.0011 0.003 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0019 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0103 0.0187
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2807 0.361
Mycobacterium tuberculosis Conserved protein 0.0069 0.0773 0.1404
Giardia lamblia Tenascin-like 0.0018 0.0125 0.9687
Onchocerca volvulus 0.0011 0.003 0.0044
Chlamydia trachomatis bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase 0.0077 0.0878 0.2799
Brugia malayi Matrixin family protein 0.003 0.0272 0.0362
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2807 0.2807
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0003
Treponema pallidum folylpolyglutamate synthetase (folC) 0.0077 0.0878 0.2839
Echinococcus granulosus aldo keto reductase 0.0011 0.003 0.0039
Mycobacterium leprae PROBABLE HYDROLASE 0.0015 0.0084 0.04
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0056 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0773 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0129 0.0159
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0139
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0773 0.2595
Mycobacterium ulcerans hydrolase 0.0015 0.0084 0.0273
Treponema pallidum UDP-N-acetylmuramate--L-alanine ligase 0.0077 0.0878 0.2839
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0003
Schistosoma mansoni aldo-keto reductase 0.0011 0.003 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0019 0.0024
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD 0.0174 0.2108 0.3825
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0056 0.0102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0441 0.5511 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.003 0.0101
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0031 0.004
Brugia malayi Integrin beta pat-3 precursor 0.0562 0.7058 1
Mycobacterium tuberculosis Possible ligase 0.0026 0.0221 0.04
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0011 0.003 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0659 0.0847

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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