Detailed information for compound 78923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.397 | Formula: C17H24N4O4
  • H donors: 4 H acceptors: 3 LogP: -0.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1
  • InChi: 1S/C17H24N4O4/c1-25-12-6-4-11(5-7-12)9-14(16(23)20-10-15(18)22)21-17(24)13-3-2-8-19-13/h4-7,13-14,19H,2-3,8-10H2,1H3,(H2,18,22)(H,20,23)(H,21,24)
  • InChiKey: OXEWAOBCQQNUML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei drug resistence protein, putative 0.0009 0.0001 0.0001
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Mycobacterium tuberculosis Possible nitrate/nitrite transporter NarK2 0.0009 0.0001 0.0026
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0002 0.0002
Mycobacterium ulcerans integral membrane protein 0.0009 0.0001 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0026 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor 0.0018 0.0011 0.0011
Plasmodium falciparum glutathione reductase 0.0019 0.0013 0.0729
Schistosoma mansoni cpg binding protein 0.0031 0.0025 0.0024
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0081 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0043
Schistosoma mansoni opsin-like receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0015 0.0014
Onchocerca volvulus 0.0018 0.0011 0.001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.0101 0.6984
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 1
Trypanosoma cruzi major facilitator superfamily, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0027 0.0021 0.1292
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Echinococcus multilocularis snurportin 1 0.0325 0.034 0.034
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0002 0.0002
Leishmania major integral membrane transport protein, putative,drug resistence protein, putative 0.0009 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Trypanosoma cruzi transporter, putative 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0015 0.0014
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0021 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0026 0.0025
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0142 0.0144 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0052 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Leishmania major hypothetical protein, unknown function 0.0009 0.0001 0.0001
Trypanosoma cruzi transporter, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0161 0.0165 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0002 0.0002
Trypanosoma cruzi transporter, putative 0.0009 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis serotonin transporter 0.0161 0.0165 0.0164
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0009 0.0001 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0021 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Brugia malayi tailless protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Plasmodium vivax transporter, putative 0.0009 0.0001 0.0003
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0021 0.002
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0011 0.0011
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.9316 1 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0017
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0017
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0155 0.0159 1
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis importin subunit beta 1 0.003 0.0024 0.0024
Echinococcus multilocularis muscleblind protein 0.0315 0.033 0.033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Possible drug efflux membrane protein 0.0009 0.0001 0.0026
Leishmania major MFS transporter, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0197 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.0315 0.033 0.033
Onchocerca volvulus 0.0021 0.0015 0.0014
Trypanosoma cruzi transporter, putative 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.0129 0.8933
Echinococcus granulosus orexin receptor type 2 0.0018 0.0011 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0015 0.0014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0013 0.1627
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0011 0.0011
Mycobacterium ulcerans transmembrane protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.0015
Trypanosoma cruzi MFS transporter, putative 0.0009 0.0001 0.0001
Schistosoma mansoni ran 0.0022 0.0016 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0015 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0015 0.0014
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0021 0.002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0012 0.0724
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.0129 0.8933
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0011
Mycobacterium leprae POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA 0.0009 0.0001 0.0024
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0021 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0015 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) DR-78 0.001 0.0002 0.0002
Mycobacterium ulcerans hypothetical protein 0.0009 0.0001 0.0024
Brugia malayi hypothetical protein 0.001 0.0002 0.0002
Mycobacterium ulcerans nitrite extrusion protein, NarK3_3 0.0009 0.0001 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0015 0.0014
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.003 0.003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.0129 0.8933
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Trypanosoma cruzi drug resistance protein, putative 0.0009 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Mycobacterium ulcerans intergral membrane protein 0.0009 0.0001 0.0024
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0052 0.3564
Schistosoma mansoni sodium/chloride dependent transporter 0.0161 0.0165 0.0164
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.1292
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0011 0.0011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0052 0.0051
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0013 0.0751
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Plasmodium falciparum thioredoxin reductase 0.0056 0.0052 0.3228
Plasmodium vivax metabolite/drug transporter, putative 0.0009 0.0001 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0015 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.003 0.1881
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0413
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0049 0.2424
Trypanosoma brucei transporter, putative 0.0009 0.0001 0.0001
Schistosoma mansoni vesicular amine transporter 0.0197 0.0203 0.0202
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Plasmodium vivax transporter, putative 0.0009 0.0001 0.0003
Mycobacterium tuberculosis Probable integral membrane nitrite extrusion protein NarU (nitrite facilitator) 0.0009 0.0001 0.0026
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0011
Echinococcus multilocularis synaptic vesicular amine transporter 0.0197 0.0203 0.0202
Mycobacterium ulcerans MFS transporter 0.0009 0.0001 0.0024
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0024 0.1499
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0021 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0015 0.0014
Toxoplasma gondii hypothetical protein 0.0009 0.0001 0.0024
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Trypanosoma brucei transporter, putative 0.0009 0.0001 0.0001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0017
Trypanosoma brucei trypanothione reductase 0.0056 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Trypanosoma cruzi protein associated with differentiation 8, putative 0.0009 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0008 0.0001 0.000002891
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0023 0.0022
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0009 0.0001 0.0026
Brugia malayi G protein-coupled receptor 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0015 0.0014
Trichomonas vaginalis Regulatory protein uhpC, putative 0.0009 0.0001 0.0037
Schistosoma mansoni biogenic amine receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Schistosoma mansoni biogenic amine receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Plasmodium vivax amine transporter, putative 0.0027 0.0021 0.1274
Brugia malayi nuclear receptor RXR 0.0011 0.0004 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0002 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0015 0.0014
Mycobacterium tuberculosis Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator) 0.0009 0.0001 0.0026
Leishmania major C-14 sterol reductase, putative 0.0093 0.0092 0.0133
Onchocerca volvulus 0.0027 0.0021 0.002
Plasmodium falciparum thioredoxin reductase 0.0019 0.0013 0.0729
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0015 0.0014
Brugia malayi Muscleblind-like protein 0.0315 0.033 0.033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0015 0.0014
Echinococcus multilocularis GPCR, family 2 0.0032 0.0026 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0017
Leishmania major hypothetical protein, conserved in leishmania 0.0009 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0011 0.0011
Schistosoma mansoni vesicular acetylcholine transporter 0.9316 1 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0021 0.002
Trichomonas vaginalis glucarate, hexuronate transporter, putative 0.0009 0.0001 0.0037
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Brugia malayi steroid hormone receptor 0.0021 0.0015 0.0014
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0011 0.0011
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0011 0.0011
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0011 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0017
Trypanosoma cruzi hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0107 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0021 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Leishmania major transporter, putative,major facilitator superfamily protein (MFS), putative 0.0009 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Echinococcus multilocularis geminin 0.0201 0.0207 0.0207
Brugia malayi Probable ClpP-like protease 0.0155 0.0159 0.0158
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0015 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0015 0.0014
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0013 0.0729
Giardia lamblia Histone acetyltransferase GCN5 0.0074 0.0072 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0013 0.0729
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0012 0.1567
Trypanosoma brucei protein associated with differentiation 7, putative 0.0009 0.0001 0.0001
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.2078
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium leprae PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK (NITRITE FACILITATOR 1) 0.0009 0.0001 0.0024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 0.0702
Trypanosoma cruzi major facilitator superfamily, putative 0.0009 0.0001 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0011 0.0011
Schistosoma mansoni bromodomain containing protein 0.0008 0.0001 0.000002891
Onchocerca volvulus 0.0024 0.0018 0.0017
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0002
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0161 0.0165 0.0164
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.003 0.003
Brugia malayi larval opioid receptor 0.0018 0.0011 0.0011
Plasmodium vivax transporter, putative 0.0009 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0015 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0013 0.0732
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.002
Echinococcus granulosus cpg binding protein 0.0031 0.0025 0.0024
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0013 0.0729
Mycobacterium ulcerans transmembrane carbohydrate transport protein 0.0009 0.0001 0.0024
Leishmania major importin beta-1 subunit, putative 0.0025 0.0018 0.0025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0018 0.0025
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0142 0.0144 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0018 0.0011 0.001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0012
Echinococcus multilocularis sex peptide receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0011 0.0011
Trypanosoma brucei major facilitator superfamily, putative 0.0009 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.003 0.003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0013 0.0017
Onchocerca volvulus 0.0018 0.0011 0.001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0013 0.0751
Echinococcus multilocularis serotonin receptor 0.0018 0.0011 0.0011
Mycobacterium ulcerans transmembrane transport protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0015 0.0014
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.0001 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0074 0.0072 1
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0009 0.0001 0.0026
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0013 0.0825
Brugia malayi ORL1-like opioid receptor 0.0018 0.0011 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0018 0.108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Trypanosoma cruzi major facilitator superfamily, putative 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0011 0.001
Entamoeba histolytica hypothetical protein 0.0025 0.0018 0.2425
Trypanosoma cruzi hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0026 0.0025
Plasmodium vivax transporter, putative 0.0009 0.0001 0.0003
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0053 0.0049 0.3071
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0015 0.0014
Plasmodium falciparum histone acetyltransferase GCN5 0.0074 0.0072 0.4479
Trypanosoma brucei protein associated with differentiation 8, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0081 0.0079 0.2682
Schistosoma mansoni cpg binding protein 0.0031 0.0025 0.0024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Integral membrane drug efflux protein Stp 0.0009 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1) 0.0009 0.0001 0.0026
Brugia malayi Abnormal catecholamine distribution protein 1 0.0197 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0018 0.1186
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0016 0.0015
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0004 0.0003
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0011 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0052 0.0051
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.9316 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0107 0.0107 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0654
Brugia malayi nuclear hormone receptor 0.0021 0.0015 0.0014
Brugia malayi RE15519p 0.0018 0.0011 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0011 0.0011
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Treponema pallidum sodium- and chloride- dependent transporter 0.0161 0.0165 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0016 0.2078
Brugia malayi Dopamine receptor protein 1 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.064
Schistosoma mansoni zinc finger protein 0.001 0.0002 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0315 0.033 0.033
Echinococcus granulosus zinc finger protein 0.0008 0.0001 0.000002891
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0101 0.01
Onchocerca volvulus 0.0018 0.0011 0.001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.0129 0.8933
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0092 0.0133
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0015 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0059 0.3726
Onchocerca volvulus 0.001 0.0002 0.0001
Mycobacterium ulcerans aminoglycosides/tetracycline-transport integral membrane protein 0.0009 0.0001 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.1567
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0011 0.0011
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Brugia malayi Dopamine receptor 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.002
Mycobacterium ulcerans integral membrane nitrite extrusion protein NarK3 0.0009 0.0001 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.0911 0.091
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0009 0.0001 0.0026
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0155 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0029 0.0023 0.0022
Schistosoma mansoni Lamin B receptor (ERG24) 0.0093 0.0092 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.003 0.003
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0009 0.0001 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0015 0.0014
Brugia malayi G-protein coupled receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0017
Brugia malayi nuclear receptor RXR 0.001 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0027 0.0021 0.002
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0021 0.002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0009 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0155 0.0159 0.0158
Echinococcus granulosus neuropeptide receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0016 0.0022
Echinococcus granulosus somatostatin receptor 0.0018 0.0011 0.0011
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.0001 0.0024
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0015 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Trichomonas vaginalis ran, putative 0.0022 0.0016 0.0535
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0015 0.0014
Onchocerca volvulus 0.0161 0.0165 0.0164
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0009 0.0001 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0013 0.0751
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0017
Echinococcus granulosus geminin 0.0201 0.0207 0.0207
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0728
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0092 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trypanosoma brucei C-8 sterol isomerase, putative 0.639 0.6857 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Loa Loa (eye worm) norepinephrine transporter 0.0161 0.0165 0.0164
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0015 0.0014
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0011 0.0011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0011 0.0011
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.0001 0.0024
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0009 0.0001 0.0026
Echinococcus granulosus fmrfamide receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0015 0.0014
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0015 0.0014
Leishmania major sterol C-24 reductase, putative 0.0048 0.0044 0.0063
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0155 0.0159 0.0158
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0002 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0281 0.0294 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0021 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Echinococcus multilocularis muscleblind protein 1 0.0315 0.033 0.033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0015 0.0014
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Onchocerca volvulus 0.0027 0.0021 0.002
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0011 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0268 0.028 0.0279
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0015 0.0014
Trypanosoma brucei transporter protein, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0021 0.002
Schistosoma mansoni opsin-like receptor 0.0018 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0002 0.0002
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0002 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0011
Toxoplasma gondii zinc finger protein 36 family 3 protein 0.0009 0.0001 0.0024
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0002
Trichomonas vaginalis Regulatory protein uhpC, putative 0.0009 0.0001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0128 0.0129 0.8132
Brugia malayi ecdysteroid receptor 0.0021 0.0015 0.0014
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.000002891
Brugia malayi Melatonin receptor type 1A 0.0018 0.0011 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0427 0.045 0.045
Mycobacterium tuberculosis Possible integral membrane efflux protein EfpA 0.0009 0.0001 0.0026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0008 0.0001 0.000002891
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0069 0.0066 0.0065
Trichomonas vaginalis glucose-6-phosphate translocase, putative 0.0009 0.0001 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0069 0.0066 0.0065
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0011 0.0011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0018 0.108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0107 0.0106
Brugia malayi Bromodomain containing protein 0.0008 0.0001 0.000002891
Echinococcus multilocularis cpg binding protein 0.0031 0.0025 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.2363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0011 0.0011
Brugia malayi ecdysone receptor 0.001 0.0002 0.0002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0011 0.0011
Echinococcus granulosus g protein coupled receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trypanosoma brucei major facilitator superfamily, putative 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.108
Brugia malayi GnHR receptor homolog 0.0018 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0002
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0009 0.0001 0.0026
Trichomonas vaginalis glucarate, hexuronate transporter, putative 0.0009 0.0001 0.0037
Schistosoma mansoni importin beta-1 0.003 0.0024 0.0024
Brugia malayi conserved hypotetical protein 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0012 0.0796
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis Hexuronate transporter, putative 0.0009 0.0001 0.0037
Mycobacterium tuberculosis Possible multidrug resistance integral membrane efflux protein EmrB 0.0009 0.0001 0.0026
Schistosoma mansoni biogenic amine receptor 0.0018 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0002 0.0002
Onchocerca volvulus 0.0018 0.0011 0.001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 0.9583
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0013 0.0729
Onchocerca volvulus 0.0036 0.003 0.0029
Brugia malayi acetyltransferase, GNAT family protein 0.0276 0.0288 0.0287
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.0101 0.6984
Leishmania major monocarboxylate transporter-like protein 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0009 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Leishmania major GTP-binding protein, putative 0.0022 0.0016 0.0022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0011 0.0011
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0081 0.0079 0.4952
Mycobacterium tuberculosis Probable reductase 0.0128 0.0129 0.8933
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0002 0.0002
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0011 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0081 0.0079 0.2682
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0011 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.108
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) solute carrier family 6 member 4 0.0161 0.0165 0.0164
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Plasmodium vivax transporter, putative 0.0009 0.0001 0.0003
Brugia malayi nuclear receptor NHR-88 0.0021 0.0015 0.0014
Echinococcus multilocularis lamin b receptor 0.0093 0.0092 0.0091
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 1
Mycobacterium ulcerans integral membrane protein 0.0009 0.0001 0.0024
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus GPCR family 2 0.0032 0.0026 0.0025
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0081 0.0079 0.4942
Trypanosoma brucei major facilitator superfamily protein (MFS), putative 0.0009 0.0001 0.0001
Mycobacterium ulcerans hypothetical protein 0.0009 0.0001 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0015 0.0014
Brugia malayi glutathione reductase 0.0056 0.0052 0.0051
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0013 0.0017
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.1292
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0155 0.0159 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0015 0.0014
Mycobacterium ulcerans integral membrane drug efflux protein 0.0009 0.0001 0.0024
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0015 0.0014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 1
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0018 0.0618
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.108
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0081 0.0079 0.4952
Echinococcus multilocularis FTZ F1 alpha 0.0107 0.0107 0.0106
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0066 0.0065
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0026 0.0025
Schistosoma mansoni coup transcription factor 0.0021 0.0015 0.0014
Brugia malayi CXXC zinc finger family protein 0.0029 0.0023 0.0022
Plasmodium vivax pantothenate transporter, putative 0.0009 0.0001 0.0003
Schistosoma mansoni myosin xvIII 0.0018 0.0011 0.0011
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0021 0.002
Brugia malayi Importin beta-1 subunit 0.003 0.0024 0.0024
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0011 0.0011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0004 0.0003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0011 0.0011
Brugia malayi RNA, U transporter 1 0.0086 0.0085 0.0084
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0011 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0011 0.0011
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0013 0.0732
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Leishmania major transporter-like protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni peptidase Clp (S14 family) 0.0155 0.0159 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0015 0.0014
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.108
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.0101 0.01
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0013 0.0017
Trypanosoma brucei Protein Associated with Differentiation 1 0.0009 0.0001 0.0001
Brugia malayi Thioredoxin reductase 0.0056 0.0052 0.0051
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0015 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0052 0.0075
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0751
Trypanosoma cruzi protein associated with differentiation 4, putative 0.0009 0.0001 0.0001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0012
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0032 0.0026 0.0025
Echinococcus granulosus vesicular acetylcholine transporter 0.9316 1 1
Echinococcus granulosus hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0011 0.0011
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0013 0.0427
Echinococcus granulosus serotonin receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0018 0.0618
Trypanosoma brucei protein associated with differentiation 4, putative 0.0009 0.0001 0.0001
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0021 0.002
Trypanosoma brucei transporter, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0015 0.0014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0016 0.0953
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0015 0.0014
Mycobacterium ulcerans multidrug resistance integral membrane efflux protein 0.0009 0.0001 0.0024
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0015 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0101 0.01
Loa Loa (eye worm) serotonin transporter b 0.0161 0.0165 0.0164
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0025
Onchocerca volvulus 0.0018 0.0011 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0107 0.0107 0.0106
Trypanosoma cruzi integral membrane transport protein, putative 0.0009 0.0001 0.0001
Echinococcus granulosus sex peptide receptor 0.0018 0.0011 0.0011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0007 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0024 0.0024
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0011 0.064
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0155 0.0159 1
Schistosoma mansoni ran 0.0022 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0026 0.0025
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0011 0.0011
Trypanosoma cruzi protein associated with differentiation 8, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0044 0.0063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0013 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.108
Plasmodium falciparum importin beta, putative 0.003 0.0024 0.1479
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.0101 0.01
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0021 0.002
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Schistosoma mansoni hypothetical protein 0.0325 0.034 0.034
Echinococcus granulosus snurportin 1 0.0325 0.034 0.034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0018 0.0011 0.001
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0052 0.323
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Leishmania major hypothetical protein, unknown function 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0413
Schistosoma mansoni bromodomain containing protein 0.0008 0.0001 0.000002891
Onchocerca volvulus 0.0018 0.0011 0.001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.1292
Onchocerca volvulus 0.0018 0.0011 0.001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0142 0.0144 0.9104
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.0724
Trypanosoma brucei major facilitator superfamily, putative 0.0009 0.0001 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0011 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0026 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0021 0.1274
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0107 0.0107 0.0106
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.0001 0.0024
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus synaptic vesicular amine transporter 0.0197 0.0203 0.0202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0002 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1148 0.1225 0.1225
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0011 0.0011
Plasmodium falciparum glutathione reductase 0.0056 0.0052 0.3228
Plasmodium vivax sugar transporter, putative 0.0009 0.0001 0.0003
Echinococcus multilocularis somatostatin receptor 0.0018 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0032 0.0026 0.0025
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0002
Trypanosoma brucei protein associated with differentiation 5, putative 0.0009 0.0001 0.0001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0018 0.108
Brugia malayi Serotonin receptor 0.0018 0.0011 0.0011
Mycobacterium leprae POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN 0.0009 0.0001 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Onchocerca volvulus 0.0281 0.0294 0.0293
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.0001 0.0024
Trypanosoma brucei protein associated with differentiation 6, putative 0.0009 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Aminoglycosides/tetracycline-transport integral membrane protein 0.0009 0.0001 0.0026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0002
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0276 0.0288 0.0287
Loa Loa (eye worm) glutathione reductase 0.0056 0.0052 0.0051
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0161 0.0165 0.0164
Plasmodium vivax SET domain protein, putative 0.0036 0.003 0.1864
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0015 0.0014
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0015 0.0014
Plasmodium vivax transporter, putative 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0013 0.0751
Mycobacterium ulcerans drug efflux membrane protein 0.0009 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0021 0.1271
Brugia malayi Pre-SET motif family protein 0.0036 0.003 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.639 0.6857 0.6857
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0013 0.0729
Trypanosoma cruzi major facilitator superfamily, putative 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0027 0.0021 0.002
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0161 0.0165 0.0164
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0011
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0276 0.0288 0.0287
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0107 0.0106
Trypanosoma cruzi transporter, putative 0.0009 0.0001 0.0001
Trichomonas vaginalis hypothetical protein 0.0009 0.0001 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0011 0.0011
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0009 0.0001 0.0026
Trypanosoma brucei Protein Associated with Differentiation, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.000002891
Schistosoma mansoni hypothetical protein 0.0201 0.0207 0.0207
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0015 0.0014
Brugia malayi nuclear receptor NHR-67 0.001 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0011 0.0011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.0101 0.6358
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0011 0.0662
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0002 0.0002
Toxoplasma gondii thioredoxin reductase 0.0056 0.0052 0.3244
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0025
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0007 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0017
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0015 0.0014
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0009 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0086 0.0084 0.0084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0016 0.0022
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0101 0.0101 0.01
Brugia malayi PHD-finger family protein 0.0008 0.0001 0.000002891
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0017
Mycobacterium ulcerans integral membrane nitrite extrusion protein NarU 0.0009 0.0001 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0013 0.0017
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.0001 0.0024
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0024 0.0035
Mycobacterium ulcerans integral membrane efflux protein EfpA 0.0009 0.0001 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0049 0.3056
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus lamin b receptor 0.0093 0.0092 0.0091
Toxoplasma gondii hypothetical protein 0.0027 0.0021 0.1292
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.1148 0.1225 0.1225
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0011 0.0011
Trypanosoma brucei protein associated with differentiation 3, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.0001 0.0024
Echinococcus granulosus g protein coupled receptor 0.0018 0.0011 0.0011
Onchocerca volvulus 0.001 0.0002 0.0001
Schistosoma mansoni zinc finger protein 0.0008 0.0001 0.000002891
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi Dopamine receptor protein 2 0.0018 0.0011 0.0011
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0011 0.0643
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0155 0.0159 0.0158
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0011
Schistosoma mansoni histamine h1 receptor 0.0018 0.0011 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0026 0.0025
Echinococcus multilocularis zinc finger protein 0.0008 0.0001 0.000002891
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Brugia malayi AKH receptor 0.0018 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0032 0.0026 0.0025
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0161 0.0165 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Brugia malayi Pre-SET motif family protein 0.0247 0.0257 0.0257
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0011 0.0011
Plasmodium vivax glutathione reductase, putative 0.0056 0.0052 0.323
Brugia malayi sulfakinin receptor protein 0.0018 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0011 0.0011
Mycobacterium ulcerans integral membrane protein 0.0009 0.0001 0.0024
Trichomonas vaginalis sucrose transport protein, putative 0.0009 0.0001 0.0037
Brugia malayi neuropeptide F receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0247 0.0257 0.0257
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0021 0.002
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Possible conserved integral membrane protein 0.0009 0.0001 0.0026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0049 0.3054
Leishmania major C-8 sterol isomerase-like protein 0.639 0.6857 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0021 0.002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0155 0.0159 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0018 0.1186
Trypanosoma cruzi C-8 sterol isomerase, putative 0.639 0.6857 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0018 0.2363
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0017
Loa Loa (eye worm) acetyltransferase 0.0276 0.0288 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0015 0.0014
Trypanosoma cruzi integral membrane transport protein, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma brucei major facilitator superfamily, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0016 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0015 0.0014
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0021 0.002
Brugia malayi ERG2 and Sigma1 receptor like protein 0.639 0.6857 0.6857
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.3266 0.3501 0.35
Echinococcus granulosus serotonin transporter 0.0161 0.0165 0.0164
Schistosoma mansoni adenoreceptor 0.0018 0.0011 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.0201 0.0207 0.0207
Mycobacterium ulcerans hypothetical protein 0.0009 0.0001 0.0024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0013 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0705
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0001
Echinococcus multilocularis serotonin receptor 0.0018 0.0011 0.0011
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.0931
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0025
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0011 0.0011
Echinococcus granulosus muscleblind protein 0.0315 0.033 0.033
Toxoplasma gondii hypothetical protein 0.0009 0.0001 0.0024
Brugia malayi putative neuropeptide receptor 0.0018 0.0011 0.0011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0021 0.002
Trypanosoma brucei C-14 sterol reductase, putative 0.0093 0.0092 0.0133
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0011 0.0004 0.0003
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0002
Trypanosoma brucei major facilitator superfamily, putative 0.0009 0.0001 0.0001
Trypanosoma brucei Protein Associated with Differentiation 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Possible conserved transmembrane protein 0.0009 0.0001 0.0026
Trypanosoma brucei riboflavin transporter 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0021 0.002
Toxoplasma gondii hypothetical protein 0.0009 0.0001 0.0024
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0002 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0018 0.0618
Mycobacterium tuberculosis Probable drug-transport integral membrane protein 0.0009 0.0001 0.0026
Echinococcus granulosus g protein coupled receptor 0.0018 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0011
Trypanosoma cruzi transporter, putative 0.0009 0.0001 0.0001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0017
Treponema pallidum NADH oxidase 0.0019 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0014
Mycobacterium leprae Aminoglycoside/tetracycline-transport integral membrane protein 0.0009 0.0001 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0142 0.0144 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0011 0.0011
Plasmodium vivax monocarboxylate transporter, putative 0.0009 0.0001 0.0003
Onchocerca volvulus 0.0029 0.0023 0.0022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0018 0.108
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0024 0.0035
Brugia malayi G-protein coupled receptor 0.0018 0.0011 0.0011
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0021 0.1271
Trichomonas vaginalis transport proetin, putative 0.0009 0.0001 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0654
Toxoplasma gondii hypothetical protein 0.0053 0.0049 0.3071
Plasmodium vivax importin-beta 2, putative 0.003 0.0024 0.1482
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.0015
Echinococcus multilocularis vesicular acetylcholine transporter 0.9316 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.0129 0.8933
Echinococcus granulosus allatostatin A receptor 0.0018 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0021 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Brugia malayi neuropeptide F receptor 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0011 0.0004 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0011 0.0011
Brugia malayi Serotonin receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0015 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0015 0.0014
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0011 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0702
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0011
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Leishmania major trypanothione reductase 0.0056 0.0052 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0001 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0026 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0011
Plasmodium falciparum transporter, putative 0.0027 0.0021 0.1271
Trichomonas vaginalis sugar transporter, putative 0.0009 0.0001 0.0037
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0009 0.0001 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0016 0.0934
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0013 0.0427
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.2363

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Ability of the compound to enhance the binding of [3H]-ADTN to dopamine receptor D2 isolated from bovine striatal membranes; inactive ChEMBL. 1971310

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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