Detailed information for compound 829544

Basic information

Technical information
  • TDR Targets ID: 829544
  • Name: N-[(4-chlorophenyl)methyl]-2-[5,7-dimethyl-6- [(4-methylphenyl)methyl]-1-oxopyrrolo[3,4-d]p yridazin-2-yl]acetamide
  • MW: 448.945 | Formula: C25H25ClN4O2
  • H donors: 1 H acceptors: 2 LogP: 3.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Cn1c(C)c2c(c1C)c(=O)n(nc2)CC(=O)NCc1ccc(cc1)Cl
  • InChi: 1S/C25H25ClN4O2/c1-16-4-6-20(7-5-16)14-29-17(2)22-13-28-30(25(32)24(22)18(29)3)15-23(31)27-12-19-8-10-21(26)11-9-19/h4-11,13H,12,14-15H2,1-3H3,(H,27,31)
  • InChiKey: MWGIPJQUXWSEKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-chlorophenyl)methyl]-2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-pyrrolo[3,4-d]pyridazin-2-yl]acetamide
  • N-[(4-chlorophenyl)methyl]-2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-2-pyrrolo[3,4-d]pyridazinyl]acetamide
  • N-(4-chlorobenzyl)-2-[1-keto-5,7-dimethyl-6-(4-methylbenzyl)pyrrolo[3,4-d]pyridazin-2-yl]acetamide
  • N-[(4-chlorophenyl)methyl]-2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-pyrrolo[3,4-d]pyridazin-2-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0135 0.0245 0.0241
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0008 0.0008
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0013 0.0004 0.0012
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0027 0.0027
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0042 0.0062 0.0051
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0181 0.0336 0.0336
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0007 0.0007
Echinococcus granulosus smad 0.0012 0.0003 0.0003
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0042 0.0062 0.0084
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0008 0.0008
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0013 0.0004 0.0012
Echinococcus multilocularis Smad4 0.0012 0.0003 0.0003
Echinococcus multilocularis GPCR, family 2 0.0014 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0021 0.002 0.002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.007 0.0095
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0042 0.0062 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0063 0.0102 0.0348
Brugia malayi jmjC domain containing protein 0.0025 0.0027 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0192 0.0192
Brugia malayi CHE-14 protein 0.0046 0.007 0.007
Echinococcus granulosus cathepsin l1 0.0014 0.0006 0.0006
Brugia malayi nuclear receptor NHR-88 0.0015 0.0008 0.0008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0063 0.0102 0.0126
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1503 0.2939 1
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0042 0.0062 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Leishmania major cathepsin L-like protease 0.0021 0.002 0.0057
Brugia malayi Cathepsin L-like precursor 0.0021 0.002 0.002
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0006 0.0006
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.5089 1 1
Onchocerca volvulus 0.0021 0.002 0.0017
Echinococcus multilocularis cysteine protease 0.0021 0.002 0.002
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0042 0.0062 0.0062
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0008 0.0008
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Onchocerca volvulus 0.0021 0.002 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0021 0.002 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0008 0.0008
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0181 0.0336 0.0409
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0004 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0081 0.0137 0.0467
Echinococcus granulosus lamin dm0 0.0016 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0077 0.0129 0.0109
Brugia malayi jmjC domain containing protein 0.0093 0.0162 0.0162
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0042 0.0062 0.0077
Brugia malayi beta-lactamase 0.0021 0.002 0.002
Echinococcus multilocularis microtubule associated protein 2 0.3151 0.6183 0.6183
Leishmania major cathepsin L-like protease 0.0081 0.0137 0.0455
Trypanosoma cruzi major cysteine proteinase, putative 0.0063 0.0103 0.0351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Plasmodium falciparum DNase I-like protein, putative 0.0013 0.0004 0.0004
Plasmodium vivax JmjC domain containing protein 0.0025 0.0027 0.0034
Plasmodium vivax vivapain-2 0.0021 0.002 0.0025
Schistosoma mansoni hypothetical protein 0.0045 0.0067 0.0067
Brugia malayi jmjC domain containing protein 0.0025 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.0021 0.002 0.002
Brugia malayi Cathepsin L-like precursor 0.0021 0.002 0.002
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.1503 0.2939 0.3621
Schistosoma mansoni microtubule-associated protein tau 0.3151 0.6183 0.6183
Brugia malayi Intermediate filament tail domain containing protein 0.0016 0.001 0.001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0012 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0016 0.001 0.001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0027 0.0027
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0004 0.0004
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0027 0.0027
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0021 0.002 0.002
Onchocerca volvulus 0.0021 0.002 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0063 0.0102 0.0141
Leishmania major cathepsin L-like protease 0.0081 0.0137 0.0455
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0013 0.0004 0.0004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0008 0.0008
Onchocerca volvulus Cathepsin L homolog 0.0021 0.002 0.0017
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0042 0.0062 0.02
Mycobacterium tuberculosis Probable hydrolase 0.0021 0.002 0.0017
Schistosoma mansoni patched 1 0.0046 0.007 0.007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0021 0.002 0.0017
Brugia malayi nuclear hormone receptor 0.0015 0.0008 0.0008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Brugia malayi uridine phosphorylase family protein 0.1503 0.2939 0.2939
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0049 0.0075 0.0088
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0192 0.0192
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.1503 0.2939 0.2939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.3586 0.704 1
Brugia malayi Smad1 0.0012 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.1503 0.2939 0.2939
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0008 0.0008
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0181 0.0336 0.0336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0077 0.0129 0.0109
Plasmodium falciparum cysteine proteinase falcipain 3 0.0021 0.002 0.0025
Schistosoma mansoni survival motor neuron protein 0.0074 0.0124 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0035 0.0035
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.007 0.007
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.3586 0.704 0.704
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0032 0.0042 0.0038
Echinococcus granulosus synaptojanin 1 0.0013 0.0004 0.0004
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Leishmania major nucleoside phosphorylase-like protein 0.1503 0.2939 1
Schistosoma mansoni uridine phosphorylase 0.1503 0.2939 0.2939
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0049 0.0075 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma cruzi nucleoside phosphorylase, putative 0.1503 0.2939 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.1503 0.2939 0.2939
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0042 0.0062 0.0062
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0027 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0042 0.0062 0.0059
Onchocerca volvulus 0.0016 0.001 0.0006
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0139 0.0252 0.0241
Mycobacterium tuberculosis Probable lipase LipD 0.0021 0.002 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0029 0.0035 0.0045
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0012 0.0003 0.0003
Brugia malayi TAR-binding protein 0.0127 0.0229 0.0229
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0042 0.0062 0.0059
Brugia malayi CCR4 0.0013 0.0004 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0283 0.0283
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0181 0.0336 0.0413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0027 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0007 0.0007
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.4133 0.8116 0.8116
Echinococcus granulosus uridine 5' monophosphate synthase 0.0042 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.007 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0021 0.002 0.002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0192 0.0236
Echinococcus multilocularis deoxyribonuclease 1 2 0.0013 0.0004 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0021 0.002 0.002
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.1503 0.2939 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0181 0.0336 0.1142
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0008 0.0008
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0013 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0063 0.0102 0.0102
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0027 0.0035
Onchocerca volvulus 0.0016 0.001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Brugia malayi MH2 domain containing protein 0.0012 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Echinococcus granulosus GPCR family 2 0.0014 0.0007 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0162 0.0162
Echinococcus granulosus peptidase Clp S14 family 0.0032 0.0042 0.0042
Echinococcus multilocularis transient receptor potential cation channel 0.0158 0.0289 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma brucei uridine phosphorylase 0.1503 0.2939 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0008 0.0008
Toxoplasma gondii aldehyde dehydrogenase 0.0077 0.0129 0.0155
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0049 0.0075 0.0055
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Onchocerca volvulus 0.0015 0.0008 0.0005
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0013 0.0004 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0063 0.0102 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0007 0.0007
Entamoeba histolytica cysteine protease, putative 0.0021 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0111 0.0197 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0035 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.002 0.0024
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0013 0.0004 0.0004
Echinococcus multilocularis smad 0.0012 0.0003 0.0003
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Schistosoma mansoni smad1 5 8 and 0.0012 0.0003 0.0003
Echinococcus multilocularis lamin dm0 0.0016 0.001 0.001
Treponema pallidum uridine phosphorylase (udp) 0.4133 0.8116 1
Brugia malayi MTAP 0.1503 0.2939 0.2939
Echinococcus multilocularis expressed conserved protein 0.0102 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0027 0.0027
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0013 0.0004 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0004 0.0012
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1503 0.2939 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0017 0.0012 0.001
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.1503 0.2939 0.2924
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Schistosoma mansoni nocturnin 0.0013 0.0004 0.0004
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.0413
Echinococcus granulosus cathepsin l cysteine peptidase 0.0021 0.002 0.002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0004 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0006 0.0006
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.5089 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0008 0.0008
Echinococcus granulosus cathepsin L cysteine proteinase 0.0021 0.002 0.002
Schistosoma mansoni purine nucleoside phosphorylase 0.5089 1 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0077 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0074 0.0124 0.0124
Giardia lamblia Adenine phosphoribosyltransferase 0.0042 0.0062 0.0059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0021 0.002 0.0017
Brugia malayi Cathepsin L-like precursor 0.0014 0.0006 0.0006
Echinococcus multilocularis purine nucleoside phosphorylase 0.5089 1 1
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0013 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.0063 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0108 0.0192 0.0268
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0077 0.0129 0.0429
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0181 0.0336 0.0336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0008 0.0008
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0027 0.0027
Brugia malayi MH2 domain containing protein 0.0012 0.0003 0.0003
Echinococcus multilocularis cysteine protease 0.0021 0.002 0.002
Schistosoma mansoni Smad4 0.0012 0.0003 0.0003
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0008 0.0005
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Echinococcus granulosus Protein patched homolog 1 0.0046 0.007 0.007
Loa Loa (eye worm) intermediate filament protein 0.0016 0.001 0.001
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.1503 0.2939 0.2939
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0021 0.002 0.0024
Entamoeba histolytica hypothetical protein 0.1503 0.2939 0.3621
Plasmodium vivax purine nucleoside phosphorylase, putative 0.4133 0.8116 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0006 0.0006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0162 0.0162
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0008 0.0008
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0008 0.0008
Echinococcus multilocularis peptidase Clp (S14 family) 0.0032 0.0042 0.0042
Schistosoma mansoni cript-related 0.0013 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0008 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0008 0.0008
Mycobacterium leprae probable uridine phosphorylase 0.1503 0.2939 0.293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0027 0.0093
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0039 0.0039
Brugia malayi beta-lactamase family protein 0.0021 0.002 0.002
Loa Loa (eye worm) RNA binding protein 0.0127 0.0229 0.0321
Echinococcus granulosus Smad4 0.0012 0.0003 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0004
Echinococcus multilocularis purine nucleoside phosphorylase 0.5089 1 1
Plasmodium vivax vivapain-2 0.0021 0.002 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0067 0.0067
Trypanosoma cruzi mitochondrial protein 99, putative 0.0013 0.0004 0.0012
Onchocerca volvulus 0.0021 0.002 0.0017
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.0162 0.0162
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0181 0.0336 0.0336
Schistosoma mansoni purine nucleoside phosphorylase 0.5089 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.0007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0077 0.0129 0.0129
Loa Loa (eye worm) ctsf protein 0.0021 0.002 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0021 0.002 0.002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0021 0.002 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2374 0.4653 0.4653
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0008 0.0005
Brugia malayi MH1 domain containing protein 0.0012 0.0003 0.0003
Schistosoma mansoni lamin 0.0016 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0035 0.0035
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0013 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.0025 0.0027 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0021 0.002 0.002
Echinococcus multilocularis purine nucleoside phosphorylase 0.5089 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Echinococcus granulosus uridine phosphorylase 1 0.1503 0.2939 0.2939
Brugia malayi hypothetical protein 0.0111 0.0197 0.0197
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0027 0.0027
Echinococcus multilocularis purine nucleoside phosphorylase 0.3586 0.704 0.704
Mycobacterium ulcerans purine nucleoside phosphorylase 0.5089 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.002 0.0025
Plasmodium vivax exodeoxyribonuclease III, putative 0.0013 0.0004 0.0004
Treponema pallidum hypothetical protein 0.0042 0.0062 0.0072
Echinococcus multilocularis synaptojanin 1 0.0013 0.0004 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Echinococcus granulosus geminin 0.0253 0.0477 0.0477
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0042 0.0062 0.0059
Onchocerca volvulus 0.0021 0.002 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0063 0.0102 0.0099
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0021 0.002 0.002
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.5089 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0008 0.0008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0074 0.0124 0.0124
Schistosoma mansoni lamin 0.0016 0.001 0.001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0032 0.0042 0.003
Schistosoma mansoni hypothetical protein 0.0253 0.0477 0.0477
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0021 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0025 0.0027 0.0081
Schistosoma mansoni synaptojanin 0.0013 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0035 0.0035
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.1142
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0021 0.002 0.0017
Treponema pallidum pfs protein (pfs) 0.1503 0.2939 0.3618
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0021 0.002 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0063 0.0102 0.0102
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0067 0.0091
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0004 0.0001
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0027 0.0029
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0229 0.0229
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0049 0.0075 0.0063
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0013 0.0004 0.0004
Echinococcus granulosus methylthioadenosine phosphorylase 0.1503 0.2939 0.2939
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.4133 0.8116 0.8116
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.4133 0.8116 1
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0027 0.0027
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0102 0.0126
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0021 0.002 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0063 0.0102 0.0099
Mycobacterium leprae Probable lipase LipE 0.0021 0.002 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0021 0.002 0.0025
Echinococcus granulosus intermediate filament protein 0.0016 0.001 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0021 0.002 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0049 0.0075 0.0088
Echinococcus granulosus phd:f box containing protein 0.0025 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.0137 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.1503 0.2939 0.2939
Trypanosoma cruzi mitochondrial protein 99, putative 0.0013 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0039
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Leishmania major methylthioadenosine phosphorylase, putative 0.1503 0.2939 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0004 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0063 0.0102 0.0122
Loa Loa (eye worm) fibroinase 0.0021 0.002 0.0024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0049 0.0075 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0021 0.002 0.002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0016 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0035 0.0035
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0096 0.0096
Echinococcus granulosus traf and tnf receptor associated protein 0.0013 0.0004 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0008 0.0008
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0013 0.0004 0.0004
Brugia malayi MH1 domain containing protein 0.0012 0.0003 0.0003
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0181 0.0336 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0008 0.0008
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Mycobacterium tuberculosis Hypothetical protein 0.1503 0.2939 0.2936
Loa Loa (eye worm) uridine phosphorylase 0.1503 0.2939 0.4172
Brugia malayi Cathepsin L-like precursor 0.0014 0.0006 0.0006
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Echinococcus granulosus adenine phosphoribosyltransferase 0.0042 0.0062 0.0062
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0013 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.0137 0.0467
Toxoplasma gondii phosphorylase family protein 0.1503 0.2939 0.3618
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0013 0.0004 0.0004
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Schistosoma mansoni uridine phosphorylase 0.1503 0.2939 0.2939
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0006 0.0008
Schistosoma mansoni synaptojanin 0.0013 0.0004 0.0004
Echinococcus granulosus ankyrin repeat protein 0.0158 0.0289 0.0289
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0195 0.0195
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0181 0.0336 0.1131
Echinococcus granulosus expressed conserved protein 0.0102 0.0179 0.0179
Mycobacterium tuberculosis Conserved protein 0.0042 0.0062 0.0059
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.5089 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.002 0.002
Brugia malayi Probable ClpP-like protease 0.0049 0.0075 0.0075
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0042 0.0062 0.0059
Brugia malayi jmjC domain containing protein 0.0093 0.0162 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0183 0.0338 0.0476
Schistosoma mansoni smad1 5 8 and 0.0012 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0021 0.002 0.0057
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0042 0.0062 0.0072
Echinococcus multilocularis purine nucleoside phosphorylase 0.3586 0.704 0.704
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.007 0.0095
Trichomonas vaginalis Phospholipase C precursor, putative 0.0013 0.0004 0.0004
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.1503 0.2939 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0042 0.0062 0.0062
Giardia lamblia UPL-1 0.1503 0.2939 0.2936
Echinococcus multilocularis neutral sphingomyelinase 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0008 0.0008
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0042 0.0062 0.0051
Leishmania major cathepsin L-like protease 0.0021 0.002 0.0057
Loa Loa (eye worm) cysteine protease 0.0021 0.002 0.0024
Schistosoma mansoni methylthioadenosine phosphorylase 0.1503 0.2939 0.2939
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0021 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Brugia malayi jmjC domain containing protein 0.0025 0.0027 0.0027
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.002 0.0025
Onchocerca volvulus Huntingtin homolog 0.0111 0.0197 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0008 0.0008
Echinococcus multilocularis uridine phosphorylase 1 0.1503 0.2939 0.2939
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0229 0.0321
Echinococcus multilocularis musashi 0.0016 0.001 0.001
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0013 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0013 0.0004 0.0004
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.1503 0.2939 0.2939
Trichomonas vaginalis esterase, putative 0.0021 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0008 0.0008
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.1142
Loa Loa (eye worm) hypothetical protein 0.0057 0.0091 0.0124
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.1503 0.2939 0.2936
Loa Loa (eye worm) jmjC domain-containing protein 0.0093 0.0162 0.0225
Echinococcus multilocularis purine nucleoside phosphorylase 0.5089 1 1
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0012 0.0003 0.0003
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0013 0.0004 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0021 0.002 0.0025
Brugia malayi exodeoxyribonuclease III family protein 0.0063 0.0102 0.0102
Schistosoma mansoni carbon catabolite repressor protein 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0111 0.0197 0.0276
Schistosoma mansoni hypothetical protein 0.0045 0.0067 0.0067
Echinococcus multilocularis cathepsin L cysteine protease 0.0021 0.002 0.002
Brugia malayi Adenine phosphoribosyltransferase 0.0042 0.0062 0.0062
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0181 0.0336 0.0336
Trypanosoma cruzi nucleoside phosphorylase, putative 0.1503 0.2939 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0067 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0008 0.0008
Onchocerca volvulus Cathepsin F homolog 0.0021 0.002 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0162 0.0162
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.001
Onchocerca volvulus 0.0074 0.0124 0.012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0229 0.0229
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0042 0.0062 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0062 0.0059
Mycobacterium ulcerans hypothetical protein 0.0042 0.0062 0.0042
Trypanosoma brucei RNA editing exonuclease 2 0.0013 0.0004 0.0012
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0013 0.0004 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0021 0.002 0.0017
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0229 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0021 0.002 0.002
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0253 0.0477 0.0477
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0049 0.0075 0.0075
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0042 0.0062 0.0062
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.007 0.007
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0004 0.0004
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0042 0.0062 0.0059
Brugia malayi cathepsin L-like precursor 0.0014 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0035 0.0035
Mycobacterium tuberculosis Probable esterase LipL 0.0021 0.002 0.0017
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0229 0.0229
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.002 0.0069
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0063 0.0102 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0008 0.0008
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0029 0.0035 0.0035
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0017 0.0012 0.0014
Echinococcus multilocularis lamin 0.0016 0.001 0.001
Treponema pallidum adenine phosphoribosyltransferase 0.0042 0.0062 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.0362 0.0691 0.0691
Echinococcus multilocularis ankyrin repeat protein 0.0158 0.0289 0.0289
Echinococcus granulosus survival motor neuron protein 1 0.0362 0.0691 0.0691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Brugia malayi MH2 domain containing protein 0.0183 0.0338 0.0338
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0074 0.0123 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0013 0.0004 0.0004
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.1503 0.2939 0.4172
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0008 0.0008
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.1503 0.2939 0.2939
Schistosoma mansoni smad 0.0012 0.0003 0.0003
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Onchocerca volvulus 0.0021 0.002 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0077 0.0129 0.0129
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0004 0.0001
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.1503 0.2939 0.3621
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0063 0.0102 0.0348
Onchocerca volvulus 0.0021 0.002 0.0017
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0008 0.0008
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0008 0.0008
Schistosoma mansoni coup transcription factor 0.0015 0.0008 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Brugia malayi Cathepsin L-like precursor 0.0021 0.002 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0139 0.0252 0.0249
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0042 0.0062 0.0042
Onchocerca volvulus 0.0021 0.002 0.0017
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.1503 0.2939 0.2936
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Toxoplasma gondii cathepsin CPL 0.0021 0.002 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0008 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0192 0.0192
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.002 0.0069
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Mycobacterium tuberculosis Conserved hypothetical protein 0.1503 0.2939 0.2936
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0181 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0004 0.0001
Leishmania major cathepsin L-like protease 0.0021 0.002 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0229 0.0229
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0013 0.0004 0.0004
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0045 0.0067 0.0067
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0042 0.0062 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0183 0.0338 0.0476
Schistosoma mansoni neutral sphingomyelinase 0.0013 0.0004 0.0004
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0004 0.0004
Leishmania major adenine phosphoribosyltransferase 0.0042 0.0062 0.02
Onchocerca volvulus 0.006 0.0096 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0008 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0021 0.002 0.0017
Toxoplasma gondii exonuclease III APE 0.0063 0.0102 0.0122
Echinococcus granulosus mothers against decapentaplegic 5 0.0012 0.0003 0.0003
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0013 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0021 0.002 0.0057
Plasmodium falciparum purine nucleoside phosphorylase 0.4133 0.8116 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0102
Toxoplasma gondii orotate phosphoribosyltransferase 0.0042 0.0062 0.0072
Brugia malayi RNA binding protein 0.0127 0.0229 0.0229
Brugia malayi intermediate filament protein 0.0016 0.001 0.001
Schistosoma mansoni peptidase Clp (S14 family) 0.0049 0.0075 0.0075
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0027 0.0027
Trypanosoma cruzi nucleoside phosphorylase, putative 0.1503 0.2939 1
Chlamydia trachomatis AMP nucleosidase 0.1503 0.2939 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.1503 0.2939 0.2939
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Echinococcus multilocularis methylthioadenosine phosphorylase 0.1503 0.2939 0.2939
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.1142
Echinococcus granulosus cathepsin l1 0.0021 0.002 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.002 0.0069
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.4133 0.8116 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0021 0.002 0.0025
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0042 0.0062 0.0062
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0013 0.0004 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0067 0.0067
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0004 0.0001
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0027 0.0029
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Toxoplasma gondii ABC1 family protein 0.0021 0.002 0.0021
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0042 0.0062 0.0084
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0077 0.0129 0.0126
Onchocerca volvulus Huntingtin homolog 0.0111 0.0197 0.0194
Onchocerca volvulus 0.0181 0.0336 0.0332
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0012 0.0003 0.0003
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0042 0.0062 0.0062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0021 0.002 0.0024
Toxoplasma gondii phosphorylase family protein 0.1503 0.2939 0.3618
Brugia malayi hypothetical protein 0.0362 0.0691 0.0691
Echinococcus granulosus tumor protein p63 0.0408 0.0782 0.0782
Onchocerca volvulus 0.0014 0.0006 0.0003
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.5089 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0021 0.002 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.002 0.0069
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.1503 0.2939 0.2936
Schistosoma mansoni hypothetical protein 0.0045 0.0067 0.0067
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0008 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0035 0.0035
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.1142
Loa Loa (eye worm) hypothetical protein 0.0362 0.0691 0.0977
Mycobacterium tuberculosis Probable lipase LipE 0.0021 0.002 0.0017
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0035
Brugia malayi steroid hormone receptor 0.0015 0.0008 0.0008
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0013 0.0004 0.0012
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0049 0.0075 0.0092
Toxoplasma gondii hypothetical protein 0.0017 0.0012 0.001
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0027 0.0027
Brugia malayi Cathepsin L-like precursor 0.0021 0.002 0.002
Brugia malayi ecdysteroid receptor 0.0015 0.0008 0.0008
Schistosoma mansoni uracil phosphoribosyltransferase 0.0042 0.0062 0.0062
Mycobacterium leprae conserved hypothetical protein 0.0021 0.002 0.0009
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0049 0.0075 0.0092
Toxoplasma gondii Purine nucleoside phosphorylase 0.4133 0.8116 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.1503 0.2939 0.2939
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0052
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.1503 0.2939 0.3621
Leishmania major cathepsin L-like protease 0.0021 0.002 0.0057
Schistosoma mansoni jumonji domain containing protein 0.0093 0.0162 0.0162
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0063 0.0102 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0008 0.0008
Loa Loa (eye worm) beta-lactamase 0.0021 0.002 0.0024
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0063 0.0102 0.0102
Echinococcus multilocularis protein patched 0.0046 0.007 0.007
Leishmania major xanthine phosphoribosyltransferase 0.0181 0.0336 0.1131
Leishmania major cysteine peptidase A (CPA) 0.0021 0.002 0.0057
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0181 0.0336 0.1142
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0181 0.0336 0.1142
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.0137 0.0467
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0077 0.0129 0.0129
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0013 0.0004 0.0004
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0181 0.0336 0.0336
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0008 0.0008
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0042 0.0062 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.0137 0.0467
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.002 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0102 0.0102
Echinococcus multilocularis traf and tnf receptor associated protein 0.0013 0.0004 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0102 0.0102
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0013 0.0004 0.0004
Onchocerca volvulus Cathepsin L homolog 0.0021 0.002 0.0017
Onchocerca volvulus 0.0021 0.002 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0021 0.002 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0027 0.0035
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus tar DNA binding protein 0.0127 0.0229 0.0229
Echinococcus multilocularis purine nucleoside phosphorylase 0.5089 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0032 0.0042 0.0038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0102 0.0126
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0013 0.0004 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.002 0.002
Echinococcus multilocularis geminin 0.0253 0.0477 0.0477
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0042 0.0062 0.0062
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0004 0.0004
Brugia malayi orotate phosphoribosyltransferase family protein 0.0042 0.0062 0.0062
Giardia lamblia Guanine phosphoribosyltransferase 0.0181 0.0336 0.0332
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0013 0.0004 0.0012
Echinococcus granulosus microtubule associated protein 2 0.3151 0.6183 0.6183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0077 0.0129 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.0162 0.0162
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0162 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0004 0.0004
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0027 0.0027
Leishmania major cathepsin L-like protease 0.0081 0.0137 0.0455
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0132
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0027 0.0027
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.1503 0.2939 0.3621
Echinococcus multilocularis protein dispatched 1 0.0053 0.0083 0.0083
Schistosoma mansoni smad1 5 8 and 0.0012 0.0003 0.0003
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.4133 0.8116 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0008 0.0008
Echinococcus granulosus neutral sphingomyelinase 0.0013 0.0004 0.0004
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0027 0.0093
Mycobacterium tuberculosis Conserved protein 0.0021 0.002 0.0017
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0049 0.0075 0.3116
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0027 0.0035
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0027 0.0027
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0021 0.002 0.002
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0158 0.0289 0.0289
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0049 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0229 0.0229
Echinococcus multilocularis tumor protein p63 0.0408 0.0782 0.0782
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0042 0.0062 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0001
Echinococcus granulosus lamin 0.0016 0.001 0.001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0017 0.0012 0.0014
Echinococcus multilocularis purine nucleoside phosphorylase 0.5089 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Plasmodium falciparum orotate phosphoribosyltransferase 0.0042 0.0062 0.0077
Echinococcus granulosus purine nucleoside phosphorylase 0.5089 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0063 0.0102 0.0348

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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