Detailed information for compound 84948

Basic information

Technical information
  • TDR Targets ID: 84948
  • Name: 8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl ]-8-azaspiro[4.5]decan-9-one
  • MW: 371.516 | Formula: C22H33N3O2
  • H donors: 0 H acceptors: 1 LogP: 3.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCN1CCC2(CC1=O)CCCC2
  • InChi: 1S/C22H33N3O2/c1-27-20-7-3-2-6-19(20)24-15-12-23(13-16-24)14-17-25-11-10-22(18-21(25)26)8-4-5-9-22/h2-3,6-7H,4-5,8-18H2,1H3
  • InChiKey: FEWRBUTUYATDFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decan-9-one
  • 8-[2-[4-(2-methoxyphenyl)piperazino]ethyl]-8-azaspiro[4.5]decan-9-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Alpha-1d adrenergic receptor Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1B Starlite/ChEMBL References
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Alpha-1a adrenergic receptor   466 aa 443 aa 31.2 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 398 aa 21.4 %
Echinococcus multilocularis neuropeptide Y receptor Alpha-1a adrenergic receptor   466 aa 419 aa 19.6 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Alpha-1a adrenergic receptor   466 aa 386 aa 31.6 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Schistosoma japonicum FMRFamide receptor, putative Alpha-1a adrenergic receptor   466 aa 374 aa 19.5 %
Echinococcus granulosus biogenic amine 5HT receptor Alpha-1a adrenergic receptor   466 aa 418 aa 30.4 %
Echinococcus granulosus rhodopsin orphan GPCR Alpha-1a adrenergic receptor   466 aa 418 aa 20.3 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 399 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0026 0.0119 0.0681
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0333 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0843 0.1464
Echinococcus granulosus dna polymerase eta 0.0081 0.0789 0.1371
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0117 0.0204
Loa Loa (eye worm) hypothetical protein 0.0044 0.0338 0.1907
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0632 0.7244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0662
Loa Loa (eye worm) hypothetical protein 0.0101 0.104 0.5868
Schistosoma mansoni zinc finger protein 0.002 0.0048 0.0098
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.058
Brugia malayi jmjC domain containing protein 0.0099 0.1009 0.5792
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0038 0.0215
Trypanosoma brucei phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0016 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0056 0.032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0056 0.032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1385 0.2405
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.1009 0.5695
Brugia malayi Phosphoglycerate kinase 0.0032 0.0194 0.1116
Brugia malayi Bromodomain containing protein 0.0039 0.0283 0.1626
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0429 0.246
Echinococcus granulosus phd:f box containing protein 0.0026 0.0117 0.0204
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0173 0.0868
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0552 0.0796
Echinococcus multilocularis dna polymerase kappa 0.0082 0.0804 0.0804
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0191
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.104 0.104
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0345 0.3953
Echinococcus multilocularis heat shock protein 0.0047 0.0378 0.0378
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1571 0.1571
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.0153
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0056 0.0056
Brugia malayi jmjC domain containing protein 0.0159 0.1742 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0087 0.0872 0.121
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.0469 0.4302
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0295 0.3312
Echinococcus granulosus geminin 0.0174 0.1933 0.3357
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0632 0.3627
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0117 0.0662
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0056 0.0115
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.104 1
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0378 0.1902
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Brugia malayi Phosphoglycerate kinase 0.0087 0.0872 0.5004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0254 0.146
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Schistosoma mansoni patched 1 0.0043 0.0333 0.0684
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0056 0.0115
Schistosoma mansoni phosphoglycerate kinase 0.0087 0.0872 0.1791
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0173 0.1976
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1571 0.2729
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0255
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0085 0.0085
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0119 0.0596
Treponema pallidum licC protein (licC) 0.0107 0.1108 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1702 0.9606
Brugia malayi Thioredoxin reductase 0.0087 0.0872 0.5005
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0184 0.1461
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.0469 0.0469
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0329 0.1656
Brugia malayi ecdysteroid receptor 0.0021 0.0056 0.032
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0632 0.1298
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0085 0.0148
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0051 0.0287
Leishmania major hypothetical protein, conserved 0.0026 0.0117 0.1341
Onchocerca volvulus 0.0037 0.0254 0.1206
Trypanosoma brucei DNA polymerase eta, putative 0.0081 0.0789 0.9052
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0254 0.0367
Plasmodium falciparum thioredoxin reductase 0.0087 0.0872 0.4391
Schistosoma mansoni hypothetical protein 0.0085 0.0843 0.1732
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0295 0.0512
Brugia malayi polk-prov protein 0.0044 0.0343 0.197
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0378 0.4331
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0056 0.032
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.1299
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0117 0.1341
Echinococcus multilocularis X box binding protein 1 0.0296 0.3425 0.3425
Brugia malayi nuclear hormone receptor 0.0021 0.0056 0.032
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0378 0.4277
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.02 0.2243 0.3238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Onchocerca volvulus Huntingtin homolog 0.0126 0.1342 0.7815
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0056 0.0097
Schistosoma mansoni DNA helicase recq1 0.002 0.0051 0.0105
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0632 0.7244
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0056 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0091
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0254 0.0367
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0872 1
Loa Loa (eye worm) endoplasmin 0.0047 0.0378 0.2133
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0056 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0056 0.032
Schistosoma mansoni jumonji domain containing protein 0.0138 0.1495 0.3072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0056 0.0115
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0168 0.095
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0168 0.0346
Giardia lamblia Phosphoglycerate kinase 0.0087 0.0872 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0119 0.0596
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0 0.0001
Echinococcus granulosus heat shock protein 90 0.004 0.0295 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0559 0.3153
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0173 0.0868
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0378 0.4075
Echinococcus multilocularis protein dispatched 1 0.005 0.0408 0.0408
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0222 0.2516 0.3631
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.1108 0.1599
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.1009 0.1753
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0009 0.0097
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0056 0.032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0056 0.032
Leishmania major DNA polymerase eta, putative 0.0081 0.0789 0.9052
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Leishmania major DNA polymerase kappa, putative 0.0017 0.0009 0.0097
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0378 0.3392
Mycobacterium ulcerans hypothetical protein 0.0107 0.1108 0.1589
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0378 0.4331
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0074 0.0425
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0843 0.1732
Leishmania major heat shock protein, putative 0.0031 0.0184 0.2112
Treponema pallidum NADH oxidase 0.003 0.0173 0.1256
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1059 0.2176
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0434
Echinococcus multilocularis muscleblind protein 1 0.0153 0.168 0.168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0056 0.0097
Echinococcus granulosus X box binding protein 1 0.0296 0.3425 0.5948
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0009 0.0097
Toxoplasma gondii thioredoxin reductase 0.0087 0.0872 0.4391
Plasmodium vivax endoplasmin, putative 0.0047 0.0378 0.1902
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1009 0.2073
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0333 0.1879
Loa Loa (eye worm) hypothetical protein 0.0161 0.1772 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0173 0.0195
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0061 0.0345
Schistosoma mansoni amine GPCR 0.0414 0.4868 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Plasmodium vivax hypothetical protein, conserved 0.003 0.0168 0.0846
Echinococcus granulosus muscleblind protein 0.0153 0.168 0.2918
Brugia malayi Bromodomain containing protein 0.0077 0.0745 0.4275
Loa Loa (eye worm) hypothetical protein 0.0126 0.1342 0.7576
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0087 0.0872 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0342 0.0494
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1009 0.2073
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0087 0.0872 0.1258
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0117 0.1341
Echinococcus multilocularis heat shock protein 90 0.0047 0.0378 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0056 0.0097
Echinococcus multilocularis phosphoglycerate kinase 1 0.0087 0.0872 0.0872
Brugia malayi hypothetical protein 0.0126 0.1342 0.7705
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Mycobacterium tuberculosis Probable oxidoreductase 0.0222 0.2516 0.3631
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0056 0.032
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0378 0.1902
Loa Loa (eye worm) hypothetical protein 0.0085 0.0843 0.4758
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0378 0.4331
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0173 0.1976
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0056 0.032
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.5758 0.5758
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0254 0.0441
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0632 0.1097
Leishmania major trypanothione reductase 0.0087 0.0872 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0343 0.3933
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.1742 0.3026
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0254 0.2915
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0173 0.0868
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.02 0.2243 0.298
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0222 0.2516 0.3631
Echinococcus granulosus heat shock protein 0.0047 0.0378 0.0656
Leishmania major phosphoglycerate kinase B, cytosolic 0.0087 0.0872 0.9998
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0429 0.2419
Mycobacterium tuberculosis Probable dehydrogenase 0.02 0.2243 0.3238
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0024 0.0134
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus granulosus expressed conserved protein 0.0095 0.0965 0.1675
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0173 0.0195
Loa Loa (eye worm) hypothetical protein 0.0081 0.0789 0.4455
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0173 0.0355
Leishmania major hypothetical protein, conserved 0.0026 0.0119 0.1357
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.1604
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0056 0.0315
Schistosoma mansoni biogenic amine (5HT) receptor 0.0161 0.1772 0.364
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0345 0.3953
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0141 0.0245
Loa Loa (eye worm) hypothetical protein 0.0126 0.1342 0.7576
Loa Loa (eye worm) hypothetical protein 0.0067 0.0627 0.3541
Echinococcus multilocularis expressed conserved protein 0.0095 0.0965 0.0965
Plasmodium vivax JmjC domain containing protein 0.0026 0.0117 0.0589
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0009 0.0097
Trypanosoma brucei unspecified product 0.0038 0.0262 0.3001
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Schistosoma mansoni hypothetical protein 0.0085 0.0843 0.1732
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.2554
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0082 0.0804 0.918
Schistosoma mansoni heat shock protein 0.0031 0.0184 0.0379
Loa Loa (eye worm) hypothetical protein 0.0051 0.0429 0.2419
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0117 0.0117
Plasmodium vivax phosphoglycerate kinase, putative 0.0087 0.0872 0.439
Toxoplasma gondii Hsp90 domain-containing protein 0.0178 0.1986 1
Trypanosoma brucei phosphoglycerate kinase 0.0032 0.0194 0.2227
Echinococcus multilocularis serotonin receptor 0.0161 0.1772 0.1772
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Brugia malayi Isocitrate dehydrogenase 0.0016 0 0.0002
Onchocerca volvulus Alhambra homolog 0.003 0.0168 0.0683
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0173 0.1976
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.0878 0.1526
Mycobacterium ulcerans hypothetical protein 0.0107 0.1108 0.1589
Echinococcus multilocularis geminin 0.0174 0.1933 0.1933
Schistosoma mansoni hypothetical protein 0.0129 0.1385 0.2845
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0016 0.0028
Plasmodium falciparum glutathione reductase 0.003 0.0173 0.0868
Schistosoma mansoni hypothetical protein 0.003 0.0168 0.0346
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0038 0.034
Schistosoma mansoni thyroid hormone receptor 0.015 0.1639 0.3367
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0552 0.0552
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0016 0.0033
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0087 0.0872 0.439
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0119 0.1357
Trichomonas vaginalis heat shock protein, putative 0.0034 0.022 0.218
Trichomonas vaginalis esterase, putative 0.0037 0.0254 0.2594
Brugia malayi Endoplasmin precursor 0.0047 0.0378 0.2169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0662
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0117 0.0589
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0038 0.0434
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0254 0.2594
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0582 0.6928 1
Brugia malayi hypothetical protein 0.0017 0.0006 0.0036
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0016 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0254 0.128
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0056 0.0097
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0184 0.032
Plasmodium falciparum phosphoglycerate kinase 0.0087 0.0872 0.439
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0254 0.0367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0056 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0056 0.0115
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.0469 0.2647
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0056 0.032
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0016 0.0016
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0119 0.1357
Echinococcus granulosus phosphoglycerate kinase 1 0.0087 0.0872 0.1514
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0295 0.3376
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.0469 0.0964
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0168 0.0846
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0107 0.1108 0.5581
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0173 0.1612
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0843 0.4839
Brugia malayi isocitrate dehydrogenase 0.0016 0 0.0002
Brugia malayi hypothetical protein 0.0155 0.1702 0.977
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0056 0.032
Trichomonas vaginalis heat shock protein, putative 0.004 0.0295 0.3077
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0469 0.0677
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.0342 0.0132
Echinococcus granulosus peregrin 0.0032 0.0198 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0056 0.0315
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0173 0.1976
Brugia malayi PHD-finger family protein 0.0026 0.0115 0.066
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0173 0.0173
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0632 0.3566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0254 0.0523
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.2695 0.3889
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0087 0.0872 0.439
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.104 0.5969
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0333 0.0578
Trypanosoma brucei phosphoglycerate kinase 0.0087 0.0872 0.9998
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0009 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0117 0.0662
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0552 0.6329
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0032 0.0194 0.2227
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0051 0.0088
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.0985 0.0985
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0429 0.246
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0173 0.099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Plasmodium falciparum heat shock protein 90, putative 0.0178 0.1986 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0254 0.0254
Plasmodium falciparum thioredoxin reductase 0.003 0.0173 0.0868
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.1639 0.1639
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0051 0.0051
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0184 0.0928
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Brugia malayi Hsp90 protein 0.0031 0.0184 0.1059
Brugia malayi beta-lactamase 0.0037 0.0254 0.146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Mycobacterium tuberculosis Conserved protein 0.0037 0.0254 0.0367
Brugia malayi heat shock protein 90 0.0047 0.0378 0.2169
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0254 0.0442
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0843 0.0843
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0184 0.2112
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0117 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Leishmania major DNA damage repair protein, putative 0.0017 0.0009 0.0097
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0173 0.0868
Trypanosoma brucei unspecified product 0.0075 0.0721 0.8262
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0582 0.6928 1
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0043 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0333 0.3536
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.058
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0582 0.6928 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0254 0.0367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0056 0.0056
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Schistosoma mansoni hypothetical protein 0.0174 0.1933 0.3971
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0254 0.0367
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0117 0.0204
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0287
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0074 0.0425
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.0872 0.4391
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.058
Echinococcus granulosus dna polymerase kappa 0.0082 0.0804 0.1395
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0009 0.0043
Mycobacterium tuberculosis Putative ferredoxin reductase 0.02 0.2243 0.3238
Entamoeba histolytica phosphoglycerate kinase, putative 0.0087 0.0872 0.8323
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1303 0.7354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0016 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.1108 0.1599
Echinococcus multilocularis muscleblind protein 0.0153 0.168 0.168
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0087 0.0872 0.9998
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.1742 0.1742
Leishmania major DNA polymerase kappa, putative 0.0061 0.0552 0.6329
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0343 0.3933
Echinococcus granulosus endoplasmin 0.0044 0.0342 0.0595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0056 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0378 0.4331
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0056 0.0056
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0107 0.1108 0.1589
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0312 0.0542
Brugia malayi beta-lactamase family protein 0.0037 0.0254 0.146
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0117 0.0589
Brugia malayi steroid hormone receptor 0.0021 0.0056 0.032
Trypanosoma brucei phosphoglycerate kinase 0.0087 0.0872 0.9998
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0184 0.0928
Loa Loa (eye worm) hypothetical protein 0.0161 0.1772 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0222 0.2516 0.3389
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Echinococcus granulosus bloom syndrome protein 0.002 0.0051 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0056 0.0097
Plasmodium falciparum phd finger protein, putative 0.003 0.0168 0.0846
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0087 0.0872 0.9998
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0254 0.2594
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0342 0.0442
Schistosoma mansoni phosphoglycerate kinase 0.0087 0.0872 0.1791
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0843 0.1464
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0168 0.0168
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Echinococcus granulosus heat shock protein 90 0.0047 0.0378 0.0656
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0056 0.032
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0342 0.365
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0804 0.9214
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0087 0.0872 0.0925
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0056 0.0097
Giardia lamblia PHD finger protein 15 0.003 0.0168 0.1848
Echinococcus granulosus neuropeptide s receptor 0.0487 0.5758 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0051 0.0287
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0009 0.0097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0254 0.1436
Echinococcus multilocularis heat shock protein 90 0.004 0.0295 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Echinococcus multilocularis bloom syndrome protein 0.002 0.0051 0.0051
Plasmodium falciparum heat shock protein 90 0.0047 0.0378 0.1902
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0038 0.0066
Mycobacterium ulcerans lipase LipD 0.0037 0.0254 0.0355
Echinococcus multilocularis dna polymerase eta 0.0081 0.0789 0.0789
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0254 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0552 0.6329
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0378 0.2133
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0632 0.7244
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0254 0.0367
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0009 0.0018
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0312 0.0312
Leishmania major phosphoglycerate kinase C, glycosomal 0.0087 0.0872 0.9998
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0191
Onchocerca volvulus Huntingtin homolog 0.0126 0.1342 0.7815
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0843 0.0843
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.5758 0.5758
Schistosoma mansoni heat shock protein 0.0047 0.0378 0.0776
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0173 0.1898
Schistosoma mansoni hypothetical protein 0.0174 0.1933 0.3971
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0804 0.9214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0016 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0173 0.1976
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0056 0.032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0254 0.0254
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0038 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0038 0.0434
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.104 0.1806
Echinococcus multilocularis peregrin 0.0032 0.0198 0.0198
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0329 0.3772
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.5758 1
Onchocerca volvulus 0.0037 0.0254 0.1206
Brugia malayi MH2 domain containing protein 0.0123 0.1303 0.748
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0119 0.0596
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0378 0.4331
Brugia malayi hypothetical protein 0.0037 0.0254 0.1458
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0184 0.2112
Schistosoma mansoni thyroid hormone receptor 0.015 0.1639 0.3367
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0173 0.0868
Plasmodium falciparum endoplasmin, putative 0.0034 0.022 0.1106
Trypanosoma brucei trypanothione reductase 0.0087 0.0872 1
Schistosoma mansoni hypothetical protein 0.0035 0.023 0.0473
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0632 0.5927
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0378 0.3392
Treponema pallidum heat shock protein 90 0.0044 0.0342 0.2844
Brugia malayi glutathione reductase 0.0087 0.0872 0.5005
Leishmania major DNA polymerase eta, putative 0.0043 0.0329 0.3772
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0056 0.0056
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0378 0.1902
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0173 0.0868
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0254 0.2594
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0632 0.7244
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0789 0.9052
Brugia malayi CHE-14 protein 0.0043 0.0333 0.1911
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0137 0.0686
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.02 0.2243 0.3238
Schistosoma mansoni coup transcription factor 0.0021 0.0056 0.0115
Echinococcus granulosus biogenic amine 5HT receptor 0.0161 0.1772 0.3077
Loa Loa (eye worm) hypothetical protein 0.0044 0.0343 0.1937
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0056 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0056 0.0097
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Toxoplasma gondii ABC1 family protein 0.0037 0.0254 0.128
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0087 0.0872 0.492
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0119 0.0596
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0378 0.4331
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0333 0.0578
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0117 0.0662
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0582 0.6928 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0173 0.0237
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0168 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0056 0.032
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Chlamydia trachomatis phosphoglycerate kinase 0.0087 0.0872 1
Plasmodium vivax heat shock protein, putative 0.0178 0.1986 1
Brugia malayi Muscleblind-like protein 0.0153 0.168 0.9645
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0 0.0002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.0872 0.1258
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0184 0.1041
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0016 0.0016
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0168 0.0292
Loa Loa (eye worm) beta-lactamase 0.0037 0.0254 0.1436
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0552 0.0959
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0342 0.3925
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0038 0.0219
Schistosoma mansoni endoplasmin 0.0047 0.0378 0.0776
Brugia malayi nuclear receptor NHR-88 0.0021 0.0056 0.032
Toxoplasma gondii exonuclease III APE 0.0019 0.0038 0.0191
Mycobacterium ulcerans phosphoglycerate kinase 0.0087 0.0872 0.1247
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0117 0.0241
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0117 0.0241
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0173 0.0237
Loa Loa (eye worm) hypothetical protein 0.0042 0.0314 0.1772
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0051 0.0088
Entamoeba histolytica recQ family helicase, putative 0.002 0.0051 0.0127
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.0789 0.4531
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0254 0.0522
Loa Loa (eye worm) hypothetical protein 0.0153 0.168 0.9483
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0092 0.0461
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0056 0.0115
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0117 0.0241
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0254 0.0355
Plasmodium falciparum glutathione reductase 0.0087 0.0872 0.4391
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0342 0.365
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.067
Schistosoma mansoni bromodomain containing protein 0.0065 0.0597 0.1227
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0804 0.1149
Treponema pallidum phosphoglycerate kinase 0.0087 0.0872 0.779
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0173 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0009 0.0097
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0087 0.0872 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0254 0.2915
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0056 0.0115
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0295 0.3376
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0173 0.1976
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0173 0.1612
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0117 0.0241
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0117 0.1341
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0254 0.2594
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0282 0.049
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.0153
Echinococcus multilocularis zinc finger protein 0.002 0.0048 0.0048
Onchocerca volvulus 0.0037 0.0254 0.1206
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0117 0.0117
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0292
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0254 0.0367
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0051 0.0292
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0184 0.0781
Echinococcus multilocularis protein patched 0.0043 0.0333 0.0333
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0255
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0378 0.4331
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0051 0.0255
Mycobacterium ulcerans beta-lactamase 0.0037 0.0254 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0056 0.032
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0117 0.0241
Schistosoma mansoni endoplasmin 0.0047 0.0378 0.0776
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.39
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0254 0.2915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0056 0.0315
Schistosoma mansoni DNA helicase recq5 0.002 0.0051 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0056 0.0315
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.02 0.2243 0.3238
Trypanosoma brucei unspecified product 0.0038 0.0262 0.3001
Trichomonas vaginalis DNA polymerase eta, putative 0.0082 0.0804 0.918
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0051 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0056 0.0315
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0292
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.0469 0.0964
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0009 0.0097
Giardia lamblia DINP protein human, muc B family 0.0061 0.0552 0.6295
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0056 0.032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0254 0.0367
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0173 0.1976
Echinococcus granulosus zinc finger protein 0.002 0.0048 0.0083
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0254 0.0254
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0804 0.1149
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0009 0.0043
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0173 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0037 0.0254 0.2915
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0051 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0056 0.0115
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0085 0.0175
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.095
Echinococcus multilocularis serotonin receptor 0.0161 0.1772 0.1772
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0434
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0378 0.4331
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0282 0.0282
Mycobacterium ulcerans heat shock protein 90 0.0044 0.0342 0.0482
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.0469 0.0815
Brugia malayi PHD-finger family protein 0.003 0.0168 0.0966
Mycobacterium tuberculosis Conserved protein 0.0037 0.0254 0.0367
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0173 0.0249
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0009 0.0043
Loa Loa (eye worm) glutathione reductase 0.0087 0.0872 0.4922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0056 0.0315
Loa Loa (eye worm) hypothetical protein 0.0043 0.0333 0.1879
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0184 0.0184
Giardia lamblia Grp94/Hsp90 0.0044 0.0342 0.3867
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0153 0.168 0.9483
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0117 0.0117
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0141 0.0141
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0117 0.0589
Mycobacterium ulcerans hypothetical protein 0.0037 0.0254 0.0355
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0843 0.1732
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0137 0.1181
Schistosoma mansoni heat shock protein 0.0047 0.0378 0.0776
Schistosoma mansoni hypothetical protein 0.0085 0.0843 0.1732
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0721 0.8262
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0056 0.032
Schistosoma mansoni DNA polymerase eta 0.0081 0.0789 0.1622
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0632 0.0632
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0056 0.0115
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0173 0.1976
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.023 0.1321
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0119 0.1357
Echinococcus multilocularis endoplasmin 0.0044 0.0342 0.0342
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.0469 0.2692
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Brugia malayi Bromodomain containing protein 0.0032 0.0198 0.1137
Trichomonas vaginalis endoplasmin, putative 0.0034 0.022 0.218
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0056 0.0115
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0843 0.4758
Brugia malayi beta-lactamase family protein 0.0037 0.0254 0.146
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0254 0.0355
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0056 0.0315
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0254 0.2594
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0051 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1303 0.7354
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0345 0.3953
Plasmodium vivax glutathione reductase, putative 0.0087 0.0872 0.4391
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.0878 0.0878
Schistosoma mansoni hypothetical protein 0.0296 0.3425 0.7036
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0173 0.1976
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.0872 0.4922
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0038 0.0055
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0051 0.0255
Onchocerca volvulus 0.0155 0.1702 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0254 0.0523
Mycobacterium tuberculosis Probable reductase 0.02 0.2243 0.3238
Schistosoma mansoni hypothetical protein 0.0037 0.0254 0.0522
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.37 nM Binding affinity to the adrenergic receptor alpha-1D of rat aorta ChEMBL. 15055991
Ki (binding) = 0.37 nM Binding affinity to the adrenergic receptor alpha-1D of rat aorta ChEMBL. 15055991
Ki (binding) = 2.33 nM Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioligand ChEMBL. 15055991
Ki (binding) = 2.33 nM Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioligand ChEMBL. 15055991
Ki (binding) = 54.43 nM In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. ChEMBL. 15055991
Ki (binding) = 54.43 nM In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. ChEMBL. 15055991
Ki (binding) = 54.99 nM Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen ChEMBL. 15055991
Ki (binding) = 54.99 nM Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen ChEMBL. 15055991

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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