Detailed information for compound 84948

Basic information

Technical information
  • TDR Targets ID: 84948
  • Name: 8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl ]-8-azaspiro[4.5]decan-9-one
  • MW: 371.516 | Formula: C22H33N3O2
  • H donors: 0 H acceptors: 1 LogP: 3.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCN1CCC2(CC1=O)CCCC2
  • InChi: 1S/C22H33N3O2/c1-27-20-7-3-2-6-19(20)24-15-12-23(13-16-24)14-17-25-11-10-22(18-21(25)26)8-4-5-9-22/h2-3,6-7H,4-5,8-18H2,1H3
  • InChiKey: FEWRBUTUYATDFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decan-9-one
  • 8-[2-[4-(2-methoxyphenyl)piperazino]ethyl]-8-azaspiro[4.5]decan-9-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Alpha-1d adrenergic receptor Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1B Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Alpha-1a adrenergic receptor   466 aa 443 aa 31.2 %
Echinococcus granulosus rhodopsin orphan GPCR Alpha-1a adrenergic receptor   466 aa 418 aa 20.3 %
Schistosoma japonicum FMRFamide receptor, putative Alpha-1a adrenergic receptor   466 aa 374 aa 19.5 %
Echinococcus multilocularis neuropeptide Y receptor Alpha-1a adrenergic receptor   466 aa 419 aa 19.6 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 399 aa 20.8 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.3 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 398 aa 21.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Alpha-1a adrenergic receptor   466 aa 386 aa 31.6 %
Echinococcus granulosus biogenic amine 5HT receptor Alpha-1a adrenergic receptor   466 aa 418 aa 30.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0032 0.0198 0.1137
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0141 0.0245
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0137 0.0686
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0582 0.6928 1
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0721 0.8262
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0843 0.1464
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0254 0.2594
Echinococcus granulosus phd:f box containing protein 0.0026 0.0117 0.0204
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0117 0.0204
Brugia malayi nuclear receptor NHR-88 0.0021 0.0056 0.032
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Onchocerca volvulus 0.0037 0.0254 0.1206
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0254 0.2594
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Trypanosoma brucei phosphoglycerate kinase 0.0087 0.0872 0.9998
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.1108 0.1599
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0056 0.0056
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0087 0.0872 0.0925
Brugia malayi Endoplasmin precursor 0.0047 0.0378 0.2169
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0126
Loa Loa (eye worm) hypothetical protein 0.0042 0.0314 0.1772
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0173 0.0237
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0009 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0119 0.0596
Echinococcus granulosus phosphoglycerate kinase 1 0.0087 0.0872 0.1514
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0173 0.1976
Brugia malayi Hsp90 protein 0.0031 0.0184 0.1059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0056 0.032
Echinococcus granulosus zinc finger protein 0.002 0.0048 0.0083
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0632 0.0632
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0378 0.4277
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0009 0.0097
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0091
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0119 0.0596
Trypanosoma brucei DNA polymerase eta, putative 0.0081 0.0789 0.9052
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0552 0.0959
Echinococcus granulosus heat shock protein 90 0.004 0.0295 0.0512
Loa Loa (eye worm) hypothetical protein 0.0067 0.0627 0.3541
Schistosoma mansoni phosphoglycerate kinase 0.0087 0.0872 0.1791
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0038 0.0055
Toxoplasma gondii thioredoxin reductase 0.0087 0.0872 0.4391
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.058
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0254 0.0355
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0378 0.4331
Loa Loa (eye worm) hypothetical protein 0.0126 0.1342 0.7576
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0292
Brugia malayi Thioredoxin reductase 0.0087 0.0872 0.5005
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0173 0.1976
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0056 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0056 0.0097
Mycobacterium ulcerans hypothetical protein 0.0107 0.1108 0.1589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0056 0.0315
Echinococcus multilocularis dna polymerase eta 0.0081 0.0789 0.0789
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.0872 0.4922
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0287
Mycobacterium ulcerans hypothetical protein 0.0107 0.1108 0.1589
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Trichomonas vaginalis esterase, putative 0.0037 0.0254 0.2594
Loa Loa (eye worm) hypothetical protein 0.0085 0.0843 0.4758
Brugia malayi Muscleblind-like protein 0.0153 0.168 0.9645
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0051 0.0051
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0119 0.1357
Loa Loa (eye worm) hypothetical protein 0.0087 0.0872 0.492
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0087 0.0872 0.1258
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0282 0.049
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0009 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1009 0.2073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0254 0.146
Echinococcus granulosus bloom syndrome protein 0.002 0.0051 0.0088
Trypanosoma brucei trypanothione reductase 0.0087 0.0872 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0016 0.0033
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0329 0.1656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Onchocerca volvulus Huntingtin homolog 0.0126 0.1342 0.7815
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0087 0.0872 1
Schistosoma mansoni hypothetical protein 0.0174 0.1933 0.3971
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Trypanosoma brucei phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0254 0.1436
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0804 0.1149
Schistosoma mansoni patched 1 0.0043 0.0333 0.0684
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0184 0.2112
Brugia malayi hypothetical protein 0.0026 0.0119 0.0681
Echinococcus multilocularis geminin 0.0174 0.1933 0.1933
Echinococcus granulosus muscleblind protein 0.0153 0.168 0.2918
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0843 0.1464
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0119 0.0596
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Toxoplasma gondii Hsp90 domain-containing protein 0.0178 0.1986 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0056 0.032
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0789 0.9052
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0117 0.0241
Plasmodium vivax glutathione reductase, putative 0.0087 0.0872 0.4391
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.1742 0.1742
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.2695 0.3889
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.058
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0184 0.0928
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0009 0.0097
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.0878 0.0878
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0117 0.0117
Leishmania major hypothetical protein, conserved 0.0026 0.0119 0.1357
Trypanosoma brucei unspecified product 0.0075 0.0721 0.8262
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0184 0.0928
Brugia malayi nuclear hormone receptor 0.0021 0.0056 0.032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0469 0.0677
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.2554
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0137 0.1181
Trichomonas vaginalis heat shock protein, putative 0.0034 0.022 0.218
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.104 0.104
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0117 0.0241
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0043 0.0488
Mycobacterium tuberculosis Conserved protein 0.0037 0.0254 0.0367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.0469 0.0964
Plasmodium falciparum glutathione reductase 0.0087 0.0872 0.4391
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0843 0.4839
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0222 0.2516 0.3631
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.02 0.2243 0.3238
Onchocerca volvulus 0.0037 0.0254 0.1206
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0117 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0559 0.3153
Brugia malayi Bromodomain containing protein 0.0077 0.0745 0.4275
Treponema pallidum heat shock protein 90 0.0044 0.0342 0.2844
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1385 0.1385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0056 0.0097
Brugia malayi beta-lactamase family protein 0.0037 0.0254 0.146
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0168 0.0346
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0552 0.6329
Onchocerca volvulus Huntingtin homolog 0.0126 0.1342 0.7815
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.0153
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.0985 0.0985
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0117 0.0589
Schistosoma mansoni thyroid hormone receptor 0.015 0.1639 0.3367
Echinococcus granulosus endoplasmin 0.0044 0.0342 0.0595
Plasmodium falciparum thioredoxin reductase 0.0087 0.0872 0.4391
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0254 0.044
Echinococcus multilocularis peregrin 0.0032 0.0198 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0333 0.3536
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0342 0.3925
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0056 0.032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.0469 0.0964
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0107 0.1108 0.5581
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0345 0.3953
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0378 0.2133
Echinococcus granulosus neuropeptide s receptor 0.0487 0.5758 1
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0843 0.4758
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0434
Echinococcus granulosus dna polymerase kappa 0.0082 0.0804 0.1395
Brugia malayi hypothetical protein 0.0017 0.0006 0.0036
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0378 0.3392
Loa Loa (eye worm) hypothetical protein 0.0161 0.1772 1
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0173 0.0173
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0038 0.034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0056 0.0056
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0051 0.0153
Schistosoma mansoni hypothetical protein 0.0085 0.0843 0.1732
Trypanosoma brucei phosphoglycerate kinase 0.0032 0.0194 0.2227
Echinococcus multilocularis serotonin receptor 0.0161 0.1772 0.1772
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.0789 0.4531
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1385 0.2405
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0173 0.099
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1303 0.7354
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0038 0.0042
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0038 0.0066
Loa Loa (eye worm) hypothetical protein 0.0081 0.0789 0.4455
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0255
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0056 0.032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0662
Plasmodium vivax hypothetical protein, conserved 0.003 0.0168 0.0846
Brugia malayi isocitrate dehydrogenase 0.0016 0 0.0002
Plasmodium vivax endoplasmin, putative 0.0047 0.0378 0.1902
Echinococcus granulosus X box binding protein 1 0.0296 0.3425 0.5948
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0117 0.1341
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0087 0.0872 0.9998
Leishmania major DNA polymerase kappa, putative 0.0017 0.0009 0.0097
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0632 0.1298
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0087 0.0872 1
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0173 0.1976
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0173 0.1898
Schistosoma mansoni coup transcription factor 0.0021 0.0056 0.0115
Trypanosoma brucei unspecified product 0.0038 0.0262 0.3001
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0038 0.0219
Brugia malayi polk-prov protein 0.0044 0.0343 0.197
Brugia malayi glutathione reductase 0.0087 0.0872 0.5005
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.0872 0.4391
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0173 0.1976
Echinococcus multilocularis heat shock protein 90 0.004 0.0295 0.0295
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0117 0.0589
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0087 0.0872 0.121
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0184 0.1041
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0345 0.3953
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0173 0.0868
Loa Loa (eye worm) hypothetical protein 0.0161 0.1772 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0254 0.0367
Brugia malayi jmjC domain containing protein 0.0099 0.1009 0.5792
Brugia malayi steroid hormone receptor 0.0021 0.0056 0.032
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0173 0.0868
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0173 0.0355
Loa Loa (eye worm) endoplasmin 0.0047 0.0378 0.2133
Schistosoma mansoni hypothetical protein 0.0174 0.1933 0.3971
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0051 0.0255
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0662
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1571 0.2729
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0056 0.0115
Leishmania major phosphoglycerate kinase B, cytosolic 0.0087 0.0872 0.9998
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0378 0.1902
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0119 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0056 0.0315
Schistosoma mansoni hypothetical protein 0.0035 0.023 0.0473
Echinococcus multilocularis X box binding protein 1 0.0296 0.3425 0.3425
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0038 0.0215
Echinococcus granulosus heat shock protein 0.0047 0.0378 0.0656
Trichomonas vaginalis endoplasmin, putative 0.0034 0.022 0.218
Echinococcus multilocularis endoplasmin 0.0044 0.0342 0.0342
Giardia lamblia Grp94/Hsp90 0.0044 0.0342 0.3867
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0056 0.032
Echinococcus multilocularis phosphoglycerate kinase 1 0.0087 0.0872 0.0872
Echinococcus granulosus heat shock protein 90 0.0047 0.0378 0.0656
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.39
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0056 0.032
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0173 0.0249
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0016 0.0033
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0078
Onchocerca volvulus Alhambra homolog 0.003 0.0168 0.0683
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0282 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0254 0.128
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0056 0.0115
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.104 0.1806
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0582 0.6928 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0342 0.0442
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0378 0.4331
Echinococcus multilocularis protein patched 0.0043 0.0333 0.0333
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0843 0.0843
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0632 0.7244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0056 0.0315
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1059 0.2176
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0342 0.0494
Schistosoma mansoni bromodomain containing protein 0.0065 0.0597 0.1227
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0056 0.0315
Echinococcus multilocularis protein dispatched 1 0.005 0.0408 0.0408
Giardia lamblia DINP protein human, muc B family 0.0061 0.0552 0.6295
Toxoplasma gondii exonuclease III APE 0.0019 0.0038 0.0191
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0254 0.2915
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0254 0.0254
Onchocerca volvulus 0.0037 0.0254 0.1206
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0051 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0429 0.246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Loa Loa (eye worm) RecQ helicase 0.002 0.0051 0.0287
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0141 0.0141
Brugia malayi Phosphoglycerate kinase 0.0087 0.0872 0.5004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0051 0.0287
Plasmodium falciparum phd finger protein, putative 0.003 0.0168 0.0846
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0378 0.4331
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0117 0.0662
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.023 0.1321
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0024 0.0134
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.02 0.2243 0.3238
Plasmodium falciparum thioredoxin reductase 0.003 0.0173 0.0868
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0184 0.0184
Trichomonas vaginalis DNA polymerase eta, putative 0.0082 0.0804 0.918
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0343 0.3933
Schistosoma mansoni hypothetical protein 0.0296 0.3425 0.7036
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0085 0.0148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Echinococcus granulosus biogenic amine 5HT receptor 0.0161 0.1772 0.3077
Toxoplasma gondii ABC1 family protein 0.0037 0.0254 0.128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0056 0.0315
Schistosoma mansoni thyroid hormone receptor 0.015 0.1639 0.3367
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0343 0.3933
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0056 0.032
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0117 0.1341
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.5758 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Loa Loa (eye worm) beta-lactamase 0.0037 0.0254 0.1436
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.0469 0.2692
Schistosoma mansoni amine GPCR 0.0414 0.4868 1
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0117 0.0117
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0429 0.246
Plasmodium falciparum glutathione reductase 0.003 0.0173 0.0868
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0254 0.0367
Echinococcus granulosus geminin 0.0174 0.1933 0.3357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.067
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.1299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0254 0.0254
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0295 0.3376
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0295 0.3376
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1009 0.2073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0168 0.0846
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0333 0.1879
Loa Loa (eye worm) hypothetical protein 0.0044 0.0338 0.1907
Schistosoma mansoni endoplasmin 0.0047 0.0378 0.0776
Trichomonas vaginalis heat shock protein, putative 0.004 0.0295 0.3077
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0061 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.1009 0.5695
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0009 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Mycobacterium tuberculosis Conserved protein 0.0037 0.0254 0.0367
Schistosoma mansoni hypothetical protein 0.0037 0.0254 0.0522
Leishmania major hypothetical protein, conserved 0.0037 0.0254 0.2915
Mycobacterium tuberculosis Probable reductase 0.02 0.2243 0.3238
Onchocerca volvulus 0.0155 0.1702 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0038 0.0434
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0009 0.0018
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0051 0.0088
Plasmodium falciparum heat shock protein 90, putative 0.0178 0.1986 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0632 0.1097
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0173 0.0237
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1303 0.7354
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Loa Loa (eye worm) hypothetical protein 0.0044 0.0343 0.1937
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0582 0.6928 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0168 0.0846
Schistosoma mansoni endoplasmin 0.0047 0.0378 0.0776
Loa Loa (eye worm) hypothetical protein 0.0153 0.168 0.9483
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.1604
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0056 0.0115
Echinococcus multilocularis muscleblind protein 1 0.0153 0.168 0.168
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0009 0.0097
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0078
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0342 0.365
Echinococcus multilocularis zinc finger protein 0.002 0.0048 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0056 0.0097
Loa Loa (eye worm) hypothetical protein 0.0101 0.104 0.5868
Leishmania major DNA polymerase eta, putative 0.0081 0.0789 0.9052
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0378 0.1902
Brugia malayi Bromodomain containing protein 0.0039 0.0283 0.1626
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0168 0.095
Schistosoma mansoni hypothetical protein 0.0085 0.0843 0.1732
Brugia malayi PHD-finger family protein 0.0026 0.0115 0.066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.02 0.2243 0.3238
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0552 0.0796
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0038 0.0434
Echinococcus multilocularis dna polymerase kappa 0.0082 0.0804 0.0804
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0107 0.1108 0.1589
Treponema pallidum NADH oxidase 0.003 0.0173 0.1256
Chlamydia trachomatis phosphoglycerate kinase 0.0087 0.0872 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0173 0.1976
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0632 0.5927
Mycobacterium ulcerans phosphoglycerate kinase 0.0087 0.0872 0.1247
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0051 0.0255
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0804 0.9214
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0051 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0056 0.0315
Giardia lamblia PHD finger protein 15 0.003 0.0168 0.1848
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0254 0.2594
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0254 0.0367
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0087 0.0872 0.439
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0254 0.0441
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0117 0.0241
Treponema pallidum licC protein (licC) 0.0107 0.1108 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0161 0.1772 0.364
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0184 0.032
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.0878 0.1526
Schistosoma mansoni DNA helicase recq5 0.002 0.0051 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Mycobacterium tuberculosis Conserved protein 0.0037 0.0254 0.0367
Schistosoma mansoni heat shock protein 0.0047 0.0378 0.0776
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0085 0.0175
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0119 0.1357
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0552 0.0552
Mycobacterium ulcerans lipase LipD 0.0037 0.0254 0.0355
Echinococcus granulosus dna polymerase eta 0.0081 0.0789 0.1371
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0016 0.0016
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.5758 0.5758
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0016 0.0033
Brugia malayi beta-lactamase 0.0037 0.0254 0.146
Plasmodium falciparum phosphoglycerate kinase 0.0087 0.0872 0.439
Mycobacterium ulcerans hypothetical protein 0.0037 0.0254 0.0355
Mycobacterium tuberculosis Probable dehydrogenase 0.02 0.2243 0.3238
Echinococcus granulosus peregrin 0.0032 0.0198 0.0344
Loa Loa (eye worm) hypothetical protein 0.0051 0.0429 0.2419
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.0469 0.0815
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0016 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0254 0.0442
Loa Loa (eye worm) hypothetical protein 0.0126 0.1342 0.7576
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0009 0.0097
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.0469 0.4302
Mycobacterium tuberculosis Probable oxidoreductase 0.0222 0.2516 0.3631
Echinococcus multilocularis heat shock protein 0.0047 0.0378 0.0378
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0843 0.1732
Leishmania major DNA polymerase kappa, putative 0.0061 0.0552 0.6329
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0074 0.0425
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0032 0.0194 0.2227
Schistosoma mansoni heat shock protein 0.0031 0.0184 0.0379
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0173 0.1976
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0632 0.7244
Loa Loa (eye worm) hypothetical protein 0.0155 0.1702 0.9606
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0038 0.0038
Brugia malayi jmjC domain containing protein 0.0159 0.1742 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Brugia malayi Phosphoglycerate kinase 0.0032 0.0194 0.1116
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0173 0.0195
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0056 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0056 0.0097
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0117 0.0117
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0173 0.1976
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0843 0.0843
Schistosoma mansoni hypothetical protein 0.0085 0.0843 0.1732
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0082 0.0804 0.918
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0173 0.1976
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0254 0.0367
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0804 0.1149
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.0469 0.2647
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0009 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0429 0.2419
Schistosoma mansoni phosphoglycerate kinase 0.0087 0.0872 0.1791
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1571 0.1571
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0056 0.0315
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0254 0.0254
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0173 0.0237
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0117 0.0204
Schistosoma mansoni hypothetical protein 0.003 0.0168 0.0346
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0333 0.0578
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.104 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Entamoeba histolytica phosphoglycerate kinase, putative 0.0087 0.0872 0.8323
Plasmodium vivax JmjC domain containing protein 0.0026 0.0117 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0552 0.6329
Brugia malayi MH2 domain containing protein 0.0123 0.1303 0.748
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0804 0.9214
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0222 0.2516 0.3389
Leishmania major DNA damage repair protein, putative 0.0017 0.0009 0.0097
Echinococcus multilocularis heat shock protein 90 0.0047 0.0378 0.0378
Treponema pallidum phosphoglycerate kinase 0.0087 0.0872 0.779
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0254 0.0355
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.0872 0.1258
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0092 0.0461
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0254 0.2915
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0254 0.2594
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0117 0.0241
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0117 0.0589
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0056 0.0115
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.1009 0.1753
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0087 0.0872 0.9998
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.02 0.2243 0.298
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0056 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0378 0.3392
Loa Loa (eye worm) hypothetical protein 0.0153 0.168 0.9483
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0168 0.0292
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0009 0.0043
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0333 0.0333
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0009 0.0043
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0173 0.1612
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0434
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0295 0.0512
Echinococcus multilocularis expressed conserved protein 0.0095 0.0965 0.0965
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0173 0.0868
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0582 0.6928 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0173 0.0868
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0342 0.365
Brugia malayi hypothetical protein 0.0155 0.1702 0.977
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0056 0.0097
Plasmodium vivax phosphoglycerate kinase, putative 0.0087 0.0872 0.439
Brugia malayi ecdysteroid receptor 0.0021 0.0056 0.032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0056 0.032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0056 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0345 0.3953
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0117 0.0241
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0632 0.7244
Schistosoma mansoni heat shock protein 0.0047 0.0378 0.0776
Loa Loa (eye worm) glutathione reductase 0.0087 0.0872 0.4922
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0056 0.0056
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0032 0.0194 0.2227
Leishmania major DNA polymerase eta, putative 0.0043 0.0329 0.3772
Leishmania major phosphoglycerate kinase C, glycosomal 0.0087 0.0872 0.9998
Leishmania major hypothetical protein, conserved 0.0026 0.0117 0.1341
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0074 0.0425
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0056 0.0115
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0843 0.1732
Entamoeba histolytica recQ family helicase, putative 0.002 0.0051 0.0127
Schistosoma mansoni DNA polymerase eta 0.0081 0.0789 0.1622
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0254 0.0367
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0056 0.0115
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0173 0.0868
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0184 0.0781
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0184 0.2112
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0255
Leishmania major trypanothione reductase 0.0087 0.0872 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0173 0.1976
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0173 0.1976
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Leishmania major heat shock protein, putative 0.0031 0.0184 0.2112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0056 0.032
Trypanosoma brucei unspecified product 0.0038 0.0262 0.3001
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0117 0.0662
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0184 0.1461
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0632 0.3566
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0173 0.03
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.1108 0.1599
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Leishmania major heat shock protein 83-1 0.0047 0.0378 0.4331
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.1639 0.1639
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0378 0.4331
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.0469 0.0469
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0254 0.0523
Brugia malayi beta-lactamase family protein 0.0037 0.0254 0.146
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0254 0.0367
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0292
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0254 0.0522
Plasmodium falciparum endoplasmin, putative 0.0034 0.022 0.1106
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0056 0.032
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.0342 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.095
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0173 0.0195
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0632 0.3627
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0009 0.0097
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0056 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0117 0.0662
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0016 0.0028
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0378 0.4331
Brugia malayi hypothetical protein 0.0037 0.0254 0.1458
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0254 0.0523
Schistosoma mansoni zinc finger protein 0.002 0.0048 0.0098
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0173 0.0868
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0056 0.0315
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0087 0.0872 0.439
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0378 0.1902
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.058
Schistosoma mansoni DNA helicase recq1 0.002 0.0051 0.0105
Brugia malayi heat shock protein 90 0.0047 0.0378 0.2169
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0632 0.7244
Echinococcus granulosus expressed conserved protein 0.0095 0.0965 0.1675
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0378 0.4331
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0173 0.1612
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0222 0.2516 0.3631
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0056 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.1436
Trypanosoma brucei phosphoglycerate kinase 0.0087 0.0872 0.9998
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0056 0.0115
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.104 0.5969
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0016 0.0028
Mycobacterium ulcerans beta-lactamase 0.0037 0.0254 0.0355
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0051 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0056 0.0115
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0378 0.4075
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0378 0.4331
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0119 0.0596
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.2156
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0191
Echinococcus multilocularis serotonin receptor 0.0161 0.1772 0.1772
Brugia malayi Isocitrate dehydrogenase 0.0016 0 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0056 0.032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0056 0.032
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Echinococcus multilocularis bloom syndrome protein 0.002 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.02 0.2243 0.3238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0315
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0804 0.9214
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0645
Plasmodium vivax heat shock protein, putative 0.0178 0.1986 1
Brugia malayi hypothetical protein 0.0126 0.1342 0.7705
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0254 0.2915
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.5758 0.5758
Giardia lamblia Phosphoglycerate kinase 0.0087 0.0872 1
Brugia malayi jmjC domain containing protein 0.0026 0.0117 0.0673
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0312 0.0542
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.0153
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0117 0.1341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0056 0.0115
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0254 0.0367
Echinococcus multilocularis muscleblind protein 0.0153 0.168 0.168
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0312 0.0312
Brugia malayi PHD-finger family protein 0.003 0.0168 0.0966
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.1742 0.3026
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0117 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0254 0.2594
Mycobacterium ulcerans heat shock protein 90 0.0044 0.0342 0.0482
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0872 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0056 0.032
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0009 0.0097
Schistosoma mansoni jumonji domain containing protein 0.0138 0.1495 0.3072
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0333 0.0578
Loa Loa (eye worm) hypothetical protein 0.0043 0.0333 0.1879
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0329 0.3772
Schistosoma mansoni hypothetical protein 0.0129 0.1385 0.2845
Plasmodium falciparum heat shock protein 90 0.0047 0.0378 0.1902
Brugia malayi CHE-14 protein 0.0043 0.0333 0.1911
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0016 0.0033
Trypanosoma brucei heat shock protein, putative 0.0047 0.0378 0.4331
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0056 0.0097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0056 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0056 0.032
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0378 0.4331
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0051 0.0088
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0295 0.3312

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.37 nM Binding affinity to the adrenergic receptor alpha-1D of rat aorta ChEMBL. 15055991
Ki (binding) = 0.37 nM Binding affinity to the adrenergic receptor alpha-1D of rat aorta ChEMBL. 15055991
Ki (binding) = 2.33 nM Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioligand ChEMBL. 15055991
Ki (binding) = 2.33 nM Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioligand ChEMBL. 15055991
Ki (binding) = 54.43 nM In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. ChEMBL. 15055991
Ki (binding) = 54.43 nM In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. ChEMBL. 15055991
Ki (binding) = 54.99 nM Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen ChEMBL. 15055991
Ki (binding) = 54.99 nM Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen ChEMBL. 15055991

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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