Detailed information for compound 85285

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 229.274 | Formula: C14H15NO2
  • H donors: 3 H acceptors: 2 LogP: 2.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCc1ccc(c(c1c1ccccc1)O)O
  • InChi: 1S/C14H15NO2/c15-9-8-11-6-7-12(16)14(17)13(11)10-4-2-1-3-5-10/h1-7,16-17H,8-9,15H2
  • InChiKey: DAKLNHHLHPIOPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0039 0.0202 0.0866
Schistosoma mansoni regulator of G protein signaling 0.002 0.0066 0.0066
Toxoplasma gondii lysine-tRNA ligase 0.0071 0.0437 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0173 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0638 0.286
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0202 0.0208
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0098 0.0632 0.2834
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0043 0.0234 0.1049
Echinococcus granulosus solute carrier family 22 0.0045 0.0246 0.0246
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0019 0.0058 0.0258
Onchocerca volvulus 0.0045 0.0246 0.1137
Onchocerca volvulus Putative transporter 0.0045 0.0246 0.1137
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0133 0.0133
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0052 0.2103
Toxoplasma gondii sugar transporter ST2 0.0045 0.0246 0.0382
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0071 0.0437 0.5996
Trypanosoma brucei glucose transporter 1E 0.0098 0.0638 0.8747
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.1061 0.4758
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.0246 0.0254
Onchocerca volvulus 0.0045 0.0246 0.1137
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0052 0.0183
Echinococcus granulosus arachidonate 5 lipoxygenase 0.023 0.1598 0.1598
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0058 0.2369
Plasmodium falciparum lysine--tRNA ligase 0.0071 0.0437 0.045
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0098 0.0632 0.0981
Plasmodium vivax proline--tRNA ligase, putative 0.0111 0.0729 0.075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0161 0.0161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0282 0.1227
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0019 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0039 0.0202 0.0202
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0107 0.07 0.3142
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0058 0.3505
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0066 0.0253
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0019 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0298
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Trichomonas vaginalis hypothetical protein 0.0011 0.0002 0.0008
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0019 0.0058 0.0058
Plasmodium falciparum proline--tRNA ligase 0.0111 0.0729 0.075
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0098 0.0632 0.0981
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.1061 0.4734
Brugia malayi Latrophilin receptor protein 2 0.005 0.0282 0.1227
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0202 0.0202
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0019 0.0058 0.0789
Loa Loa (eye worm) hypothetical protein 0.0095 0.0614 0.2755
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.0246 0.3381
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0246 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0114 0.0114
Echinococcus granulosus dnaJ subfamily B 0.1284 0.9264 0.9264
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.001
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0327 0.0327
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0066 0.0066
Leishmania major glucose transporter, lmgt2 0.0098 0.0638 0.8747
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0019 0.0058 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0372 0.0372
Brugia malayi hypothetical protein 0.0039 0.0202 0.0866
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Schistosoma mansoni regulator of G protein signaling 0.002 0.0066 0.0066
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0638 0.286
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0298
Brugia malayi DNA polymerase family B containing protein 0.0019 0.0058 0.0214
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.0082 0.1124
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0372 0.0372
Onchocerca volvulus 0.0045 0.0246 0.1137
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0052 0.0233
Echinococcus multilocularis tumor protein p63 0.0669 0.4786 0.4786
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0012 0.001 0.0045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.1061 0.4734
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0246 0.3381
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0019 0.0058 0.002
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0082 0.0082
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0327 0.4481
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.2229 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0372 0.1669
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.005 0.0285 0.0285
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0052 0.1186
Loa Loa (eye worm) hypothetical protein 0.0098 0.0634 0.2844
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0019 0.0058 0.0058
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0066 0.0066
Echinococcus granulosus solute carrier family 22 0.0045 0.0246 0.0246
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0372 0.1631
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0066 0.0298
Plasmodium vivax hexose transporter 0.0317 0.2229 0.2294
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.0246 0.6499
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0066 0.0066
Trypanosoma brucei glucose transporter 2A 0.0098 0.0638 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0638 0.286
Brugia malayi Sugar transporter family protein 0.0045 0.0246 0.1065
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.0246 0.5639
Trichomonas vaginalis STE family protein kinase 0.0019 0.0057 0.0258
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0327 0.1465
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0019 0.0058 0.0059
Toxoplasma gondii DNA polymerase 0.0019 0.0058 0.0089
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0298
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0093 0.0093
Echinococcus granulosus expressed protein 0.0386 0.2732 0.2732
Onchocerca volvulus 0.0045 0.0246 0.1137
Leishmania major glucose transporter, lmgt1 0.0098 0.0638 0.8747
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.0246 0.5639
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.0729 1
Schistosoma mansoni glucose transport protein 0.0317 0.2229 0.2229
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0019 0.0057 0.0057
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0019 0.0058 0.0059
Onchocerca volvulus 0.0045 0.0246 0.1137
Giardia lamblia Prolyl-tRNA synthetase 0.0095 0.0614 0.2019
Schistosoma mansoni regulator of G protein signaling 0.002 0.0066 0.0066
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0058
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0052 0.0053
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0066 0.0066
Brugia malayi major facilitator superfamily protein 0.0045 0.0246 0.1065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0317
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0058 0.006
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0019 0.0058 0.0059
Schistosoma mansoni protein kinase 0.0012 0.001 0.001
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0066 0.0298
Mycobacterium ulcerans hypothetical protein 0.0016 0.0037 0.0841
Toxoplasma gondii sugar transporter ST1 0.0045 0.0246 0.0382
Plasmodium falciparum protein kinase 6 0.1347 0.9718 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0058 0.0218
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0723
Schistosoma mansoni hypothetical protein 0.005 0.0282 0.0282
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0167 1
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Echinococcus multilocularis lysyl tRNA synthetase 0.0071 0.0437 0.0437
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0638 0.8747
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0317
Schistosoma mansoni sugar transporter 0.0045 0.0246 0.0246
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0058 0.0789
Chlamydia trachomatis lysine--tRNA ligase 0.0071 0.0437 1
Brugia malayi PXA domain containing protein 0.002 0.0066 0.0253
Brugia malayi Sugar transporter family protein 0.0317 0.2229 1
Onchocerca volvulus 0.0127 0.0849 0.4763
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0052 0.0188
Giardia lamblia Sugar-proton symporter 0.0045 0.0246 0.0699
Plasmodium falciparum calcium-dependent protein kinase 1 0.0098 0.0632 0.0651
Schistosoma mansoni hypothetical protein 0.0364 0.2571 0.2571
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0327 0.4481
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0026 0.0114 0.051
Leishmania major glucose transporter/membrane transporter D2, putative 0.0098 0.0638 0.8747
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0058 0.0023
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0058 0.0789
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0019 0.0058 0.0789
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Brugia malayi PXA domain containing protein 0.002 0.0066 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0372 0.0372
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0066 0.0066
Leishmania major protein kinase, putative 0.0098 0.0632 0.8667
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0058 0.0058
Echinococcus multilocularis PAK box P21 Rho binding 0.0012 0.001 0.001
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0729 1
Echinococcus multilocularis expressed protein 0.0386 0.2732 0.2732
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0082 0.0289
Echinococcus granulosus solute carrier family 22 0.0045 0.0246 0.0246
Echinococcus granulosus disco interacting protein 2 0.0043 0.0234 0.0234
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0953 0.0953
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0047 0.0261 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0282 0.0282
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0095 0.0614 0.2165
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0327 0.4481
Entamoeba histolytica hypothetical protein 0.002 0.0066 0.0234
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0058 0.0258
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0066 0.0253
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0437 0.0437
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0637 0.2858
Onchocerca volvulus 0.0045 0.0246 0.1137
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0052 0.3113
Echinococcus granulosus axis inhibition protein axin 0.002 0.0066 0.0066
Schistosoma mansoni protein kinase 0.0019 0.0057 0.0057
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0058 0.0058
Brugia malayi major facilitator superfamily protein 0.0045 0.0246 0.1065
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0058 0.0262
Onchocerca volvulus 0.0039 0.0202 0.0871
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0282 0.1266
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0327 0.0327
Entamoeba histolytica protein kinase, putative 0.0019 0.0057 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0298
Echinococcus granulosus RUN 0.0039 0.0202 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Echinococcus multilocularis calcium dependent protein kinase 0.0091 0.0585 0.0585
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0161 0.0161
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0098 0.0632 0.0981
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0026 0.0114 0.051
Giardia lamblia Hexose transporter 0.0045 0.0246 0.0699
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0095 0.0614 0.0614
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0095 0.0614 0.2755
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0246 0.1065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0327 0.1465
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0111 0.0729 0.1131
Loa Loa (eye worm) sugar transporter 0.0317 0.2229 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis STE family protein kinase 0.0019 0.0057 0.0258
Brugia malayi Pre-SET motif family protein 0.0217 0.1503 0.6728
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0504
Schistosoma mansoni lipoxygenase 0.0161 0.1094 0.1094
Toxoplasma gondii hypothetical protein 0.0094 0.0607 0.0942
Brugia malayi MAP kinase sur-1 0.0056 0.0327 0.1426
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0139 0.0139
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0052 0.1186
Onchocerca volvulus 0.0045 0.0246 0.1137
Schistosoma mansoni regulator of G protein signaling 0.002 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0019 0.0058 0.0789
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0094 0.0607 0.0625
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.0082 0.0127
Echinococcus granulosus PAK box P21 Rho binding 0.0012 0.001 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0282 0.0282
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.1503 0.6743
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0114 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Entamoeba histolytica hypothetical protein 0.002 0.0066 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0637 0.0637
Brugia malayi hypothetical protein 0.0045 0.0246 0.1065
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0045
Schistosoma mansoni protein kinase 0.0019 0.0057 0.0057
Toxoplasma gondii facilitative glucose transporter GT1 0.0317 0.2229 0.3459
Schistosoma mansoni survival motor neuron protein 0.005 0.0285 0.0285
Onchocerca volvulus 0.0045 0.0246 0.1137
Echinococcus granulosus lysyl tRNA synthetase 0.0071 0.0437 0.0437
Echinococcus granulosus General substrate transporter 0.0273 0.1905 0.1905
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0282 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0637 0.0637
Loa Loa (eye worm) CXXC zinc finger family protein 0.0127 0.0849 0.381
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0161 0.0161
Leishmania major glucose transporter, lmgt3 0.0098 0.0638 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0327 0.0327
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0317 0.2229 0.2229
Schistosoma mansoni cpg binding protein 0.0127 0.0849 0.0849
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Schistosoma mansoni hypothetical protein 0.0107 0.07 0.07
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0019 0.0058 0.0214
Echinococcus multilocularis solute carrier family 22 0.0045 0.0246 0.0246
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0019 0.0057 0.0258
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0098 0.0632 0.0632
Echinococcus multilocularis solute carrier family 22 0.0045 0.0246 0.0246
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0052 0.0052
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.0801
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0019 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0637 0.0637
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0131 0.0543
Schistosoma mansoni hypothetical protein 0.0317 0.2229 0.2229
Loa Loa (eye worm) acetyltransferase 0.0146 0.0983 0.4409
Mycobacterium ulcerans sugar transporter 0.0045 0.0246 0.5639
Brugia malayi Pre-SET motif family protein 0.0033 0.0161 0.068
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0058 0.0262
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0052 0.2103
Echinococcus granulosus GPCR family 2 0.005 0.0282 0.0282
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0052 0.0233
Brugia malayi hypothetical protein 0.0245 0.1702 0.7625
Schistosoma mansoni hypothetical protein 0.1284 0.9264 0.9264
Entamoeba histolytica protein kinase, putative 0.0019 0.0057 0.0203
Giardia lamblia Kinase, STE STE20 0.0019 0.0057 0.002
Schistosoma mansoni sugar transporter 0.0045 0.0246 0.0246
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0066 0.0066
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0066 0.0066
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0246 0.1106
Trichomonas vaginalis STE family protein kinase 0.0019 0.0057 0.0258
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0058 0.0801
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Onchocerca volvulus 0.0045 0.0246 0.1137
Plasmodium vivax sugar transporter, putative 0.0045 0.0246 0.0254
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0638 0.286
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0638 0.8747
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.023 0.1598 0.1598
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0437 1
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0052 0.0262
Onchocerca volvulus 0.0045 0.0246 0.1137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0282 0.0282
Onchocerca volvulus 0.0039 0.0202 0.0871
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0317
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.0082 0.0127
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0208 0.0214
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0066 0.0066
Echinococcus granulosus cpg binding protein 0.0133 0.0887 0.0887
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0071 0.0437 0.5996
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0327 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0638 0.286
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0298
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0907
Plasmodium falciparum calcium-dependent protein kinase 4 0.0098 0.0632 0.0651
Brugia malayi CXXC zinc finger family protein 0.0127 0.0849 0.3781
Plasmodium vivax SET domain protein, putative 0.0033 0.0161 0.0166
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0202 0.0907
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0019 0.0058 0.0789
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0317
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0774 0.3472
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0066 0.0066
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.006 0.0359 1
Brugia malayi WH1 domain containing protein 0.0051 0.0296 0.1288
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Schistosoma mansoni tyrosine kinase 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0002 0.0008
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0047 0.0261 0.0261
Entamoeba histolytica hypothetical protein 0.0071 0.0437 0.1541
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0372 0.0372
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0246 0.1065
Loa Loa (eye worm) hypothetical protein 0.0245 0.1702 0.7636
Plasmodium falciparum protein kinase 7 0.0897 0.6444 0.6631
Schistosoma mansoni microtubule-associated protein tau 0.1386 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1702 0.1702
Echinococcus multilocularis beta adrenergic receptor kinase 0.0026 0.0114 0.0114
Toxoplasma gondii histone lysine methyltransferase SET1 0.0176 0.1199 0.1861
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0019 0.0058 0.0058
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0052 0.1186
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0983 0.0983
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0632 0.2834
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0082 0.0082
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0066 0.0066
Schistosoma mansoni axis inhibition protein axin 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0052 0.0052
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0095 0.0614 0.2722
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0327 0.4481
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0093 0.0093
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0019 0.0058 0.0258
Schistosoma mansoni cpg binding protein 0.0133 0.0887 0.0887
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0012 0.001 0.0036
Plasmodium falciparum calcium-dependent protein kinase 3 0.0098 0.0632 0.0651
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0234 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0161
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.0246 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0327 0.0327
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0437 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.0246 0.0246
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0019 0.0057 0.0057
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0071 0.0437 0.196
Loa Loa (eye worm) hypothetical protein 0.0095 0.0614 0.2755
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1702 0.1702
Entamoeba histolytica protein kinase, putative 0.0019 0.0057 0.0203
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0907
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0019 0.0057 0.0057
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0167 0.3811
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0037 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0327 0.1465
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.0246 0.1106
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0095 0.0614 1
Brugia malayi lysyl-tRNA synthetase 0.0071 0.0437 0.1924
Schistosoma mansoni protein kinase 0.0019 0.0057 0.0057
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0058 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0246 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Echinococcus granulosus calcium dependent protein kinase 0.0091 0.0585 0.0585
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0058 0.0789
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0058 0.0801
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.07 0.311
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0008
Plasmodium vivax calcium-dependent protein kinase, putative 0.0098 0.0632 0.0651
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0359 0.5587
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0066 0.0066
Trypanosoma cruzi hexose transporter, putative 0.0054 0.0313 0.4296
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Loa Loa (eye worm) hypothetical protein 0.0077 0.0484 0.2173
Brugia malayi hypothetical protein 0.0045 0.0246 0.1065
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0058 0.0258
Giardia lamblia DNA repair protein RAD52 0.0401 0.2837 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.0246 0.0246
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.0246 0.0246
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0052 0.0188
Entamoeba histolytica hypothetical protein 0.0114 0.0751 0.2649
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.0082 0.0084
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0638 0.8747
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0052 0.008
Onchocerca volvulus 0.0033 0.0161 0.0623
Onchocerca volvulus 0.0098 0.0634 0.3468
Brugia malayi hypothetical protein 0.0045 0.0246 0.1065
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0167 0.3811
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0327 0.1465
Trypanosoma brucei protein kinase, putative 0.0056 0.0327 0.4481
Leishmania major hypothetical protein, conserved 0.0045 0.0246 0.3381
Echinococcus granulosus beta-adrenergic receptor kinase 0.0026 0.0114 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0637 0.0637
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0019 0.0058 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0133 0.0598
Echinococcus granulosus solute carrier family 22 0.0045 0.0246 0.0246
Onchocerca volvulus 0.005 0.0285 0.137
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Plasmodium vivax DNA polymerase alpha, putative 0.0019 0.0058 0.0059
Echinococcus multilocularis GPCR, family 2 0.005 0.0282 0.0282
Loa Loa (eye worm) sugar transporter 0.0045 0.0246 0.1106
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0058 0.0789
Plasmodium falciparum hexose transporter 0.0317 0.2229 0.2294
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0372 0.0372
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0043 0.0234 0.0234
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0066 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.1386 1 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0095 0.0614 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Plasmodium falciparum mitogen-activated protein kinase 2 0.0513 0.3654 0.376
Schistosoma mansoni polycystin 1-related 0.0039 0.0202 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0327 0.1465
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Toxoplasma gondii exonuclease III APE 0.0019 0.0058 0.0091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0058 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0246 0.1106
Schistosoma mansoni glucose transport protein 0.0317 0.2229 0.2229
Echinococcus multilocularis wiskott Aldrich syndrome protein 0.0035 0.0173 0.0173
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0246 0.1106
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.0614 0.0614
Trypanosoma cruzi hexose transporter 0.0098 0.0638 0.8747
Loa Loa (eye worm) hypothetical protein 0.0157 0.1061 0.4758
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0037 0.0504
Schistosoma mansoni glucose transport protein 0.0317 0.2229 0.2229
Brugia malayi DNA polymerase alpha catalytic subunit 0.0019 0.0058 0.0214
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0208 0.0561
Schistosoma mansoni protein kinase 0.0098 0.0632 0.0632
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0066 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0161
Onchocerca volvulus 0.0045 0.0246 0.1137
Brugia malayi hypothetical protein 0.002 0.0066 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0052 0.008
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0114 0.0751 0.2649
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0045
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0066 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0246 0.1106
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0019 0.0057 0.0057
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0058
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0233
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Plasmodium vivax CDK-related protein kinase 6, putative 0.1347 0.9718 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0298
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0062 0.0374 0.1676
Schistosoma mansoni lipoxygenase 0.023 0.1598 0.1598
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0258
Schistosoma mansoni hypothetical protein 0.005 0.0282 0.0282
Brugia malayi hypothetical protein 0.002 0.0066 0.0253
Brugia malayi MH2 domain containing protein 0.0117 0.0774 0.3442
Echinococcus multilocularis solute carrier family 22 0.0045 0.0246 0.0246
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0066 0.0253
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0233
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0504
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0019 0.0058 0.0058
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.0246 0.0246
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0774 0.3472
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0019 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0298
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.001
Brugia malayi Sugar transporter family protein 0.0045 0.0246 0.1065
Brugia malayi SET domain containing protein 0.0013 0.0018 0.0036
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0729 1
Echinococcus multilocularis solute carrier family 22 0.0045 0.0246 0.0246
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0082 0.0084
Entamoeba histolytica protein kinase, putative 0.0019 0.0057 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0161 0.025
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0052 0.0188
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0082 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0637 0.0637
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0066 0.0066
Brugia malayi Protein kinase domain 0.0019 0.0057 0.0213
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0098 0.0632 0.8667
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0019 0.0058 0.0058
Echinococcus granulosus tumor protein p63 0.0669 0.4786 0.4786
Echinococcus multilocularis dnaJ subfamily B 0.1284 0.9264 0.9264
Onchocerca volvulus 0.0045 0.0246 0.1137
Brugia malayi Cam kinase protein 1 0.0098 0.0632 0.2801
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0071 0.0437 0.6932
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0298
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Onchocerca volvulus 0.0045 0.0246 0.1137
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0372 0.0372
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0298
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Echinococcus multilocularis RUN 0.0039 0.0202 0.0202
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0234 0.105
Echinococcus granulosus tar DNA binding protein 0.0062 0.0372 0.0372
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0637 0.2826
Schistosoma mansoni loxhd1 0.0039 0.0202 0.0202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0133 0.0133
Giardia lamblia Lysyl-tRNA synthetase 0.0071 0.0437 0.1383
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0327 0.0327
Plasmodium falciparum calcium-dependent protein kinase 5 0.0098 0.0632 0.0651
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0317
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0327 0.4481
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.0729 1
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0019 0.0058 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0317
Brugia malayi DNA polymerase delta catalytic subunit 0.0019 0.0058 0.0214
Schistosoma mansoni rab6-interacting 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Trichomonas vaginalis set domain proteins, putative 0.0247 0.172 0.7714
Schistosoma mansoni axis inhibition protein axin 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Toxoplasma gondii DNA polymerase family B protein 0.0019 0.0058 0.0089
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0019 0.0058 0.0058
Brugia malayi Doublecortin family protein 0.0039 0.0202 0.0866
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0173 0.0777
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0071 0.0317
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0234 0.0363
Schistosoma mansoni sugar transporter 0.0045 0.0246 0.0246
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0208 0.0733
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0058 0.006
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0202 0.0208
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0638 0.8747
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0098 0.0632 0.2834
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0098 0.0632 0.2834
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0298
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0019 0.0058 0.0258
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0098 0.0632 0.2801
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0039 0.0206 0.0925
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0019 0.0057 0.0057
Schistosoma mansoni sugar transporter 0.0045 0.0246 0.0246
Brugia malayi RNA binding protein 0.0062 0.0372 0.1631
Leishmania major modification methylase-like protein 0.0022 0.0082 0.1124
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0098 0.0632 0.0651
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0638 0.8747
Onchocerca volvulus 0.0247 0.172 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0058 0.0789
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0437 0.0437
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0192 0.1322 0.1322
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trypanosoma brucei glucose transporter, putative 0.0098 0.0638 0.8747
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0058 0.0206
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0066 0.0066
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Trichomonas vaginalis STE family protein kinase 0.0019 0.0057 0.0258
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0246 0.1106
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0246 0.1106
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0372 0.1669
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0098 0.0632 0.0651
Schistosoma mansoni hypothetical protein 0.005 0.0282 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Loa Loa (eye worm) hypothetical protein 0.005 0.0282 0.1266
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Entamoeba histolytica p21-activated kinase 0.0019 0.0057 0.0203
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0066 0.0066
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0058 0.1336
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0327 0.4481
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Brugia malayi TAR-binding protein 0.0062 0.0372 0.1631
Schistosoma mansoni protein kinase 0.0098 0.0632 0.0632
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.0246 0.1106
Schistosoma mansoni regulator of G protein signaling 0.002 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0012 0.001 0.0036
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0019 0.0058 0.0789
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0161
Echinococcus multilocularis disco interacting protein 2 0.0043 0.0234 0.0234
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0983 0.4384
Plasmodium vivax lysine--tRNA ligase, putative 0.0071 0.0437 0.045
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.0246 0.0382
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0359 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0298
Loa Loa (eye worm) hypothetical protein 0.0071 0.0437 0.196
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.0246 0.3381
Brugia malayi Disco-interacting protein 2 homolog 0.0043 0.0234 0.1009
Trichomonas vaginalis DNA polymerase II, putative 0.0019 0.0058 0.0258
Trypanosoma cruzi sugar transporter, putative 0.0045 0.0246 0.3381
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.0208 0.0932
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0638 0.286
Entamoeba histolytica protein kinase, putative 0.0098 0.0632 0.2227
Trichomonas vaginalis helicase, putative 0.002 0.0071 0.0317
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0052 0.0468
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0019 0.0058 0.0203
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0638 0.286
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0729 1
Entamoeba histolytica hypothetical protein 0.002 0.0066 0.0234
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0095 0.0614 0.2722
Trichomonas vaginalis STE family protein kinase 0.0019 0.0057 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Plasmodium falciparum calcium-dependent protein kinase 2 0.0098 0.0632 0.0651
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0066 0.0066
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0047 0.0261 0.0261
Echinococcus granulosus geminin 0.0364 0.2571 0.2571
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Schistosoma mansoni hypothetical protein 0.0364 0.2571 0.2571
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.0246 0.0246
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0071 0.0317
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0098 0.0632 0.0651
Schistosoma mansoni protein kinase 0.0098 0.0632 0.0632
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.0246 0.5639
Schistosoma mansoni glucose transporter 0.0045 0.0246 0.0246
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0019 0.0058 0.002
Trypanosoma brucei sugar transporter, putative 0.0045 0.0246 0.3381
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0401 0.2837 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0632 0.0632
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0234 0.105
Trypanosoma cruzi glucose transporter, putative 0.0045 0.0246 0.3381
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0983 0.0983
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0066 0.0298
Echinococcus granulosus axis inhibition protein axin 0.002 0.0066 0.0066
Entamoeba histolytica protein kinase, putative 0.0098 0.0632 0.2227
Schistosoma mansoni hypothetical protein 0.005 0.0282 0.0282
Onchocerca volvulus 0.0043 0.0234 0.1061
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0234 0.0363
Schistosoma mansoni cpg binding protein 0.0133 0.0887 0.0887
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0513 0.3654 0.567
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0317
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0037 0.0504
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.0246 0.6499
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0638 0.8747
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0019 0.0058 0.0089
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0327 0.0987
Brugia malayi serine/threonine-protein kinase PAK 7 0.0019 0.0057 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0637 0.0637
Toxoplasma gondii sugar transporter ST3 0.0045 0.0246 0.0382
Echinococcus multilocularis geminin 0.0364 0.2571 0.2571
Toxoplasma gondii protein kinase, putative 0.0897 0.6444 1
Echinococcus multilocularis General substrate transporter 0.0273 0.1905 0.1905
Echinococcus multilocularis cpg binding protein 0.0133 0.0887 0.0887
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0246 0.1106
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0093 0.0093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0372 0.1669
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0114 0.0114
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0246 0.1065
Schistosoma mansoni rab6-interacting 0.0039 0.0202 0.0202
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0234 0.0241
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0285 0.1239
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0058 0.0789
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1106
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0513 0.3654 0.376
Loa Loa (eye worm) RGS-3 protein 0.002 0.0066 0.0298
Leishmania major lysyl-tRNA synthetase, putative 0.0071 0.0437 0.5996
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0161 0.0161
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0019 0.0058 0.0059
Onchocerca volvulus 0.0045 0.0246 0.1137
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2229 0.2229
Onchocerca volvulus 0.0045 0.0246 0.1137
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0026 0.0114 0.0467
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.0801
Onchocerca volvulus 0.0045 0.0246 0.1137
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0012 0.001 0.001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0327 0.4481

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 20 % Compound was tested for inhibition of [3H]-spiroperidol binding against Dopamine receptor D2 at 10e-5 M; IA= Inactive ChEMBL. 3761310
Inhibition (binding) < 20 % Compound was tested for inhibition of [3H]-spiroperidol binding against Dopamine receptor D2 at 10e-5 M; IA= Inactive ChEMBL. 3761310
Ki (binding) = 1500 nM Displacement of [3H]-fenoldopam from Dopamine receptor D1 of rat striatum membranes ChEMBL. 3761310
Ki (binding) = 1500 nM Displacement of [3H]-fenoldopam from Dopamine receptor D1 of rat striatum membranes ChEMBL. 3761310

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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