Detailed information for compound 874293

Basic information

Technical information
  • TDR Targets ID: 874293
  • Name: 3-(4-ethylphenyl)-1-(2-methyl-1-oxoisoquinoli n-4-yl)urea
  • MW: 321.373 | Formula: C19H19N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)Nc1cn(C)c(=O)c2c1cccc2
  • InChi: 1S/C19H19N3O2/c1-3-13-8-10-14(11-9-13)20-19(24)21-17-12-22(2)18(23)16-7-5-4-6-15(16)17/h4-12H,3H2,1-2H3,(H2,20,21,24)
  • InChiKey: HOAASFWVZBNQOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-ethylphenyl)-1-(2-methyl-1-oxo-4-isoquinolyl)urea
  • 3-(4-ethylphenyl)-1-(1-keto-2-methyl-4-isoquinolyl)urea
  • 3-(4-ethylphenyl)-1-(2-methyl-1-oxo-isoquinolin-4-yl)urea
  • E679-0390
  • NCGC00141447-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0414 0.0541 0.6043
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Echinococcus granulosus axis inhibition protein axin 0.002 0.0007 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0028 0.0322
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0032 0.0205
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.0257 0.0737
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0137 0.1051
Schistosoma mansoni axis inhibition protein axin 0.002 0.0007 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.012
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Plasmodium vivax unspecified product 0.0146 0.0178 0.5596
Echinococcus granulosus bloom syndrome protein 0.0023 0.001 0.001
Onchocerca volvulus 0.014 0.017 0.381
Leishmania major phosphatidylinositol 3-kinase, putative 0.061 0.0808 0.2206
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0868 0.6965
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0026 0.0136
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0107 0.1243
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.014 0.017 0.1366
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0022 0.0531
Giardia lamblia Phosphatidylinositol 4-kinase 0.014 0.017 0.1798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0011 0.0024
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.039 0.0509 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.0574 0.459
Brugia malayi Pre-SET motif family protein 0.0251 0.0321 0.2578
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0664 0.0881 0.2539
Schistosoma mansoni hypothetical protein 0.018 0.0223 0.1185
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0394 0.0514 0.597
Entamoeba histolytica hypothetical protein 0.0038 0.0031 0.0197
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0674 0.0895 0.4754
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0664 0.0881 0.2539
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0007 0.0007
Echinococcus multilocularis tumor protein p63 0.0361 0.047 0.047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.039 0.0509 0.4058
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0053 0.1124
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.017 0.1317
Onchocerca volvulus Serine\/threonine kinase homolog 0.0205 0.0257 0.5778
Giardia lamblia Kinase, CMGC CK2 0.0146 0.0178 0.1891
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0059
Schistosoma mansoni hypothetical protein 0.0103 0.0119 0.063
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.047 0.0618 0.4971
Trypanosoma brucei unspecified product 0.0023 0.0011 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0168
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0007 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0119 0.0906
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0053 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0063
Brugia malayi PXA domain containing protein 0.0022 0.0009 0.0073
Echinococcus multilocularis dna polymerase eta 0.0023 0.0011 0.0011
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0145 0.1119
Toxoplasma gondii hypothetical protein 0.0071 0.0076 0.0881
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0007 0.0057
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0026 0.0026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0011 0.0057
Echinococcus multilocularis bloom syndrome protein 0.0023 0.001 0.001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.0257 0.0737
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.0322 0.1925
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1401 0.1882 0.1882
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0011 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Brugia malayi Protein kinase domain containing protein 0.0343 0.0446 0.3583
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 0.5
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0063 0.0063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0011 0.0023
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0357 0.0464 0.0463
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0051 0.0271
Echinococcus multilocularis casein kinase ii subunit beta 0.0039 0.0032 0.0032
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0063 0.3297
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Echinococcus multilocularis geminin 0.018 0.0223 0.0223
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.014 0.017 0.1968
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0011 0.011
Echinococcus multilocularis expressed protein 0.0399 0.0521 0.0521
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0137 0.7759
Plasmodium vivax hypothetical protein 0.014 0.017 0.5303
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Echinococcus granulosus expressed conserved protein 0.0087 0.0098 0.0098
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0028 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.0673 0.0894 0.5336
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0044
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0085 0.0095 0.0266
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0146 0.0178 0.1063
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0137 0.1051
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0237 0.0301 0.1598
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0053 0.0053
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.014 0.017 0.017
Schistosoma mansoni hypothetical protein 0.014 0.017 0.0902
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0049 0.0045 0.0309
Echinococcus granulosus casein kinase ii subunit alpha 0.0146 0.0178 0.0178
Leishmania major phosphatidylinositol 4-kinase, putative 0.014 0.017 0.0458
Brugia malayi hypothetical protein 0.002 0.0007 0.0057
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0086 0.0086
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0137 0.0368
Schistosoma mansoni phosphatidylinositol 4-kinase 0.014 0.017 0.0902
Leishmania major hypothetical protein, conserved 0.2706 0.3655 1
Trichomonas vaginalis conserved hypothetical protein 0.0254 0.0324 0.2562
Loa Loa (eye worm) hypothetical protein 0.014 0.017 0.1014
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0011 0.0271
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0022 0.0133
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0254 0.0324 0.0324
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0011 0.0031
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0237 0.0301 0.2377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.0517 0.4123
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.017 0.1014
Brugia malayi Cytochrome P450 family protein 0.0032 0.0022 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.061 0.0808 0.648
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trypanosoma brucei polo-like protein kinase 0.0205 0.0257 0.2869
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0216 0.0273 0.215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.0842 0.675
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0053 0.0373
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0137 0.0137
Onchocerca volvulus 0.0029 0.0018 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0027 0.0179
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.014 0.017 0.0483
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0011 0.011
Loa Loa (eye worm) hypothetical protein 0.0254 0.0324 0.1934
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0049 0.0045 0.0045
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0063 0.3297
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0007 0.0057
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.039 0.0509 0.5681
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0049 0.0045 0.0363
Brugia malayi hypothetical protein 0.0174 0.0216 0.1738
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0076 0.056
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0023 0.0135
Brugia malayi M-phase phosphoprotein, mpp8 0.0107 0.0125 0.1006
Brugia malayi hypothetical protein 0.0504 0.0663 0.5332
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0053 0.0053
Schistosoma mansoni protein kinase 0.0146 0.0178 0.0945
Entamoeba histolytica hypothetical protein 0.0778 0.1036 0.8319
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0191 0.0239 0.192
Brugia malayi Probable ClpP-like protease 0.0094 0.0107 0.0864
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.017 0.1014
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0301 0.0862
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0321 0.1914
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0363 0.0473 0.2823
Echinococcus granulosus serine protein kinase ATM 0.0372 0.0485 0.0485
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0119 0.0954
Toxoplasma gondii ck2 beta subunit 0.0039 0.0032 0.0372
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0011 0.0011
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0931 0.1243 1
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0137 0.1051
Toxoplasma gondii hypothetical protein 0.0033 0.0023 0.0267
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0696 0.0925 0.7422
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0026 0.0136
Schistosoma mansoni lamin 0.0029 0.0018 0.0095
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0186 0.0186
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0053 0.1595
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0237 0.0301 0.2377
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0045 0.0236
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0109 0.0577
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0343 0.0446 0.3583
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0031 0.0253
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0301 0.0862
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0931 0.1243 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0137 0.0818
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0472 0.062 0.4955
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0026 0.0026
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0007 0.0007
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0137 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0032 0.0205
Leishmania major phosphatidylinositol 3-kinase, putative 0.0237 0.0301 0.0817
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0093 0.0105 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0063
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0655 0.0868 0.2371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.003 0.1202
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0293 0.0378 0.415
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0368 0.0479 0.3818
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0655 0.0868 0.9703
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.0842 0.675
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0032 0.0889
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0022 0.012
Loa Loa (eye worm) RecQ helicase 0.0023 0.001 0.0059
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0022 0.0249
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0674 0.0895 0.7181
Entamoeba histolytica protein kinase rad3, putative 0.0357 0.0464 0.3692
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0051 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0011 0.011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0357 0.0464 0.1332
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0202 0.1074
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0868 0.6965
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0109 0.0577
Schistosoma mansoni intermediate filament proteins 0.0029 0.0018 0.0095
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.014 0.017 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0076 0.056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0000069199 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0095 0.0109 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0011 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0696 0.0925 0.7422
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0031 0.0167
Onchocerca volvulus 0.0286 0.0368 0.8256
Loa Loa (eye worm) phosphatidylinositol kinase 0.014 0.017 0.1014
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0026 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0343 0.0446 0.0445
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0007 0.0057
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.014 0.017 0.5552
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0026 0.0026
Brugia malayi serine/threonine-protein kinase plk-2 0.0205 0.0257 0.2071
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0504 0.0663 0.396
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0543 0.0717 0.7985
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0664 0.0881 0.4681
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.014 0.017 0.1317
Trichomonas vaginalis PIKK family atypical protein kinase 0.061 0.0808 0.648
Entamoeba histolytica serine/threonine protein kinase, putative 0.0205 0.0257 0.2026
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0119 0.0906
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0343 0.0446 0.2661
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0237 0.0301 0.349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0357 0.0464 0.3728
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0237 0.0301 0.0301
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0026 0.0026
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0622 0.0824 0.2249
Brugia malayi Protein kinase domain containing protein 0.0143 0.0173 0.1395
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0007 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0868 0.6965
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.014 0.017 0.1317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0103
Brugia malayi intracellular kinase 0.0054 0.0053 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0076 0.056
Echinococcus multilocularis expressed conserved protein 0.0087 0.0098 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.2566 0.3464 1
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0095 0.0109 0.0109
Brugia malayi intermediate filament protein 0.0029 0.0018 0.0145
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.014 0.017 0.017
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0022 0.0249
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0032 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0011 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0173 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Schistosoma mansoni casein kinase II beta subunit 0.0039 0.0032 0.0172
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.014 0.017 0.1968
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0237 0.0301 0.2377
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0674 0.0895 0.2578
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0031 0.0031
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Toxoplasma gondii GAF domain-containing protein 0.0035 0.0027 0.0307
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0026 0.0026
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0053 0.0147
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0011 0.0024
Brugia malayi Death domain containing protein 0.0015 0.0000069255 0.0001
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0237 0.0301 0.242
Plasmodium falciparum GAF domain-related protein, putative 0.0035 0.0027 0.07
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.014 0.017 0.1366
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0011 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.016
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0133 0.016 0.1286
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0085 0.0095 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.055 0.4394
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0108
Brugia malayi 6-phosphofructokinase 0.0116 0.0137 0.1102
Echinococcus multilocularis musashi 0.0029 0.0018 0.0018
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0085 0.0095 0.0266
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0053 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0372 0.0485 0.3864
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Echinococcus granulosus lamin 0.0029 0.0018 0.0018
Echinococcus granulosus axis inhibition protein axin 0.002 0.0007 0.0007
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0205 0.0257 0.1538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.0895 0.7181
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0145 0.1119
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0237 0.0301 0.2377
Trypanosoma brucei protein kinase, putative 0.0054 0.0053 0.0584
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0137 0.0818
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0107 0.0125 0.0747
Brugia malayi phosphofructokinase 0.0116 0.0137 0.1102
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0343 0.0446 0.2661
Brugia malayi Uncoordinated protein 44 0.0015 0.0000069255 0.0001
Brugia malayi Serotonin receptor 0.0499 0.0656 0.5278
Entamoeba histolytica hypothetical protein 0.0372 0.0485 0.3864
Leishmania major phosphatidylinositol kinase related protein, putative 0.0156 0.0191 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.0479 0.3818
Plasmodium falciparum casein kinase 2, alpha subunit 0.0146 0.0178 0.583
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0022 0.012
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.061 0.0808 0.903
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0674 0.0895 0.7181
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0674 0.0895 0.0895
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.0198 0.1181
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0053 0.0139
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0931 0.1243 0.3585
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0000069255 0.000000030078
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.012
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0053 0.0479
Leishmania major DNA polymerase eta, putative 0.0023 0.0011 0.0023
Brugia malayi hypothetical protein 0.0038 0.0031 0.0253
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.039 0.0509 0.4058
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0273 0.215
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.014 0.017 0.0483
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0145 0.1119
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.016
Brugia malayi Pre-SET motif family protein 0.0036 0.0028 0.0226
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0441 0.0578 0.3071
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0018 0.0108
Entamoeba histolytica hypothetical protein 0.0038 0.0031 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0085 0.0095 0.1048
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0035
Echinococcus multilocularis casein kinase ii subunit alpha 0.0146 0.0178 0.0178
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.018 0.0223 0.2485
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0137 0.0818
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.014 0.017 0.1366
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0205 0.0257 0.0257
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0032 0.0889
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.014 0.017 0.1968
Echinococcus multilocularis lamin 0.0029 0.0018 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0049 0.0045 0.0309
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0237 0.0301 0.0301
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0674 0.0895 0.2578
Giardia lamblia Casein kinase II beta chain 0.0039 0.0032 0.0244
Loa Loa (eye worm) hypothetical protein 0.0306 0.0395 0.2359
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0254 0.0324 0.0324
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0039 0.0032 0.0372
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0232 0.0294 0.0843
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0035 0.0027 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.0895 0.7181
Mycobacterium tuberculosis Conserved hypothetical protein 0.014 0.017 1
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0000069255 0.0000000056617
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Entamoeba histolytica hypothetical protein 0.014 0.017 0.1317
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.014 0.017 0.1317
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0237 0.0301 0.1598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0868 0.6965
Trichomonas vaginalis PIKK family atypical protein kinase 0.061 0.0808 0.648
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1401 0.1882 0.1882
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0093 0.0105 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.012
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0022 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.061 0.0808 0.648
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0085 0.0095 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Toxoplasma gondii hypothetical protein 0.0035 0.0027 0.0307
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0037 0.003 0.0324
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0011 0.0011
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0032 0.0725
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0032 0.0086
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0007 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Echinococcus granulosus cyclin dependent kinase 19 0.0143 0.0173 0.0173
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.014 0.017 0.1888
Brugia malayi SH2 domain containing protein 0.0363 0.0473 0.3802
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0202 0.1074
Schistosoma mansoni axis inhibition protein axin 0.002 0.0007 0.0037
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0237 0.0301 0.0301
Onchocerca volvulus 0.0107 0.0125 0.2805
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0093 0.0105 0.0558
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0674 0.0895 0.7197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0401 0.0524 0.4178
Echinococcus multilocularis serine protein kinase ATM 0.0372 0.0485 0.0485
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Schistosoma mansoni fkbp-rapamycin associated protein 0.0357 0.0464 0.2462
Onchocerca volvulus 0.0038 0.0031 0.0705
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0026 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0027 0.0234
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0237 0.0301 1
Entamoeba histolytica casein kinase, putative 0.0146 0.0178 0.1383
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0673 0.0894 0.0893
Brugia malayi hypothetical protein 0.0108 0.0125 0.1007
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0133 0.016 0.0849
Echinococcus granulosus geminin 0.018 0.0223 0.0223
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0867 0.1156 0.1156
Echinococcus multilocularis survival motor neuron protein 1 0.0504 0.0663 0.0663
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0007 0.0037
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.039 0.0509 0.4058
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0063 0.0063
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0007 0.0042
Entamoeba histolytica hypothetical protein 0.014 0.017 0.1317
Echinococcus multilocularis Zinc finger, PHD finger 0.0237 0.0301 0.0301
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0048 0.0334
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0676 0.0897 0.7213
Brugia malayi FAT domain containing protein 0.0254 0.0324 0.2604
Echinococcus multilocularis high voltage activated calcium channel beta 0.0093 0.0105 0.0105
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0191 0.0239 0.1425
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0673 0.0894 0.0893
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0674 0.0895 0.2444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.0517 0.4123
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0622 0.0824 0.4919
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0022
Loa Loa (eye worm) RGS-3 protein 0.002 0.0007 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0372 0.0485 0.3899
Brugia malayi PXA domain containing protein 0.0022 0.0009 0.0073
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0237 0.0301 0.2377
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0137 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0031 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.025 0.0318 0.19
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0032 0.0378
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0778 0.1036 0.8319
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0107 0.0107
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0146 0.0178 0.5596
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0007 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0011 0.0271
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0368 0.2917
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0343 0.0446 0.0445
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0085 0.0095 0.0266
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.003 0.0079
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0107 0.5741
Leishmania major phosphatidylinositol kinase, putative 0.014 0.017 0.0458
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.017 0.1014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0824 0.6606
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0003 0.0018
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.014 0.017 0.0483
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0007 0.0007
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0137 0.0727
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0372 0.0485 0.2575
Echinococcus multilocularis cyclin dependent kinase 19 0.0143 0.0173 0.0173
Echinococcus granulosus casein kinase ii subunit beta 0.0039 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.0514 0.4104
Schistosoma mansoni lamin 0.0029 0.0018 0.0095
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0049 0.0045 0.0309
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.014 0.017 0.5303
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0186 0.0186
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0012 0.0096
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0072 0.0078 0.4197
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0007 0.0057
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0137 0.1521
Schistosoma mansoni hypothetical protein 0.0087 0.0098 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Echinococcus granulosus lamin dm0 0.0029 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0931 0.1243 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0343 0.0446 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.0517 0.4123
Onchocerca volvulus 0.0048 0.0045 0.0999
Leishmania major cytochrome p450-like protein 0.0021 0.0007 0.0013
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0357 0.0464 0.0463
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Entamoeba histolytica hypothetical protein 0.014 0.017 0.1317
Trypanosoma cruzi target of rapamycin kinase 3 0.0655 0.0868 0.2501
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0027 0.1502
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0085 0.0095 0.0503
Loa Loa (eye worm) hypothetical protein 0.0108 0.0125 0.0748
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0931 0.1243 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0047 0.0324
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.017 0.1014
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0301 0.0817
Echinococcus granulosus dna polymerase kappa 0.0023 0.0011 0.0011
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0000069255 0.0000000056617
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0145 0.1119
Onchocerca volvulus 0.0054 0.0053 0.1193
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0026 0.0026
Brugia malayi hypoxia-induced factor 1 0.0161 0.0198 0.1591
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0137 0.1051
Schistosoma mansoni DNA polymerase eta 0.0023 0.0011 0.0057
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Schistosoma mansoni hypothetical protein 0.0152 0.0186 0.0986
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.001 0.008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 0.7721
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0085 0.0095 0.0709
Giardia lamblia Hypothetical protein 0.014 0.017 0.1798
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0026 0.0026
Mycobacterium leprae conserved hypothetical protein 0.014 0.017 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.014 0.017 0.5552
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Entamoeba histolytica hypothetical protein 0.0038 0.0031 0.0197
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0674 0.0895 0.2444
Leishmania major DNA polymerase kappa, putative 0.0023 0.0011 0.0023
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0063 0.2723
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0047 0.0129
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0931 0.1243 0.3585
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0032 0.0378
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.014 0.017 0.017
Brugia malayi PAS domain containing protein 0.0052 0.005 0.0401
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0048 0.0334
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0137 0.1051
Schistosoma mansoni hypothetical protein 0.0038 0.0031 0.0167
Onchocerca volvulus 0.0053 0.0051 0.1143
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0085 0.0095 0.0709
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0107 0.1243
Schistosoma mansoni survival motor neuron protein 0.0103 0.0119 0.063
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0156 0.0191 0.0545
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0007 0.0007
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0085 0.0095 0.1048
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0137 0.1051
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Onchocerca volvulus 0.0103 0.0119 0.2662
Echinococcus granulosus expressed protein 0.0399 0.0521 0.0521
Echinococcus granulosus single minded 2 0.0038 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0622 0.0824 0.9204
Brugia malayi Csnk2b protein 0.0039 0.0032 0.026
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0049 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0868 0.6965
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.0464 0.3692
Brugia malayi hypothetical protein 0.002 0.0007 0.0057
Brugia malayi 6-phosphofructokinase 0.0116 0.0137 0.1102
Loa Loa (eye worm) hypothetical protein 0.0034 0.0026 0.0154
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0007 0.0007
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0027 0.1502
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0674 0.0895 0.0895
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0664 0.0881 0.0881
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0085 0.0095 0.0709
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0028 0.0149
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.014 0.017 0.0483
Echinococcus multilocularis lamin dm0 0.0029 0.0018 0.0018
Echinococcus multilocularis 0.014 0.017 0.017
Trypanosoma cruzi casein kinase II, putative 0.0146 0.0178 0.0507
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.025 0.0318 0.0912
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0011 0.0024
Onchocerca volvulus 0.0029 0.0018 0.0403
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0039 0.0032 0.0351
Schistosoma mansoni hypothetical protein 0.0055 0.0054 0.0285
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0107 0.3068
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0791 0.1053 0.8458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0028 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0011 0.0024
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0674 0.0895 1
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0007 0.0007
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0053 0.0613
Toxoplasma gondii CMGC kinase, CK2 family 0.0146 0.0178 0.2063
Plasmodium vivax SET domain protein, putative 0.0036 0.0028 0.0227
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0007 0.0007
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.7379 1 1
Schistosoma mansoni hypothetical protein 0.018 0.0223 0.1185
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.014 0.017 0.5303
Echinococcus granulosus dna polymerase eta 0.0023 0.0011 0.0011
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0372 0.0485 0.5412
Echinococcus granulosus high voltage activated calcium channel beta 0.0093 0.0105 0.0105
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0009 0.0054
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.014 0.017 0.5303
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0137 0.0727
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.014 0.017 0.017
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0031 0.1861
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0053 0.0318
Loa Loa (eye worm) gastrulation defective protein 1 0.0139 0.0169 0.1006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0202 0.0202
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0372 0.0485 0.1393
Loa Loa (eye worm) calcium channel 0.0034 0.0026 0.0154
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0023 0.0583
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0022 0.0531
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0674 0.0895 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0294 0.1757
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0237 0.0301 0.349
Loa Loa (eye worm) hypothetical protein 0.0357 0.0464 0.2768
Toxoplasma gondii target of rapamycin (TOR), putative 0.065 0.0861 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0028 0.0149
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.014 0.017 0.0902
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0053 0.0373
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1401 0.1882 1
Toxoplasma gondii hypothetical protein 0.0035 0.0027 0.0307
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0301 0.3355
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.017 0.1317
Toxoplasma gondii FATC domain-containing protein 0.0372 0.0485 0.5626
Schistosoma mansoni serine/threonine protein kinase 0.0343 0.0446 0.2367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.0895 0.7181
Entamoeba histolytica hypothetical protein 0.0038 0.0031 0.0197
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0011 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0011 0.0087
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0032 0.0205
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0047 0.0324
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 0.3436
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0032 0.0725
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0012 0.0012
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Onchocerca volvulus 0.014 0.017 0.381
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0072 0.0078 0.5417
Loa Loa (eye worm) phosphatidylinositol 3 0.1248 0.1674 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Echinococcus granulosus tumor protein p63 0.0361 0.047 0.047
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0053 0.0479
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0137 0.0389
Brugia malayi follicle stimulating hormone receptor 0.0253 0.0322 0.2592
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0174 0.0216 0.1291
Entamoeba histolytica protein kinase domain containing protein 0.0146 0.0178 0.1383
Leishmania major hypothetical protein, unknown function 0.014 0.017 0.0458
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0012 0.0071
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0012 0.0071
Entamoeba histolytica protein kinase, putative 0.0054 0.0053 0.0373
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Schistosoma mansoni hypothetical protein 0.0254 0.0324 0.172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0065
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0205 0.0257 0.0257
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0137 0.7936
Schistosoma mansoni single-minded 0.0052 0.005 0.0264
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.001 0.0023
Loa Loa (eye worm) Csnk2b protein 0.0039 0.0032 0.0193
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.014 0.017 0.0902
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0018 0.0145
Leishmania major casein kinase II, putative 0.0146 0.0178 0.0481
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.014 0.017 0.1888
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0018 0.0108
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0143 0.0173 0.1036
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0023 0.0056
Brugia malayi Protein kinase domain containing protein 0.0019 0.0005 0.004
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0237 0.0301 0.1797
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0012 0.0012
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0835 0.6695
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0086 0.0086
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0011 0.0031
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 0.7721
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0178 0.1383
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0196 0.1532
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0664 0.0881 0.7087
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0205 0.0257 0.0698
Loa Loa (eye worm) hypothetical protein 0.0133 0.016 0.0955
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0664 0.0881 0.0881
Echinococcus granulosus survival motor neuron protein 1 0.0504 0.0663 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0861 0.6911
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0022 0.0124
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0137 0.1051
Loa Loa (eye worm) hypothetical protein 0.0394 0.0514 0.3072
Echinococcus granulosus intermediate filament protein 0.0029 0.0018 0.0018
Giardia lamblia GTOR 0.0674 0.0895 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0053 0.0282
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Echinococcus granulosus protein kinase shaggy 0.0054 0.0053 0.0053
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0059
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0107 0.057
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0439 0.0575 0.4591
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0011 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0257 0.2026
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.005 0.0264
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0032 0.0205
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0031 0.0031
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0095 0.0709
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0026 0.0136
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0107 0.7434
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0028 0.0028
Schistosoma mansoni kinase 0.0106 0.0123 0.0651
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0094 0.0107 0.0642
Brugia malayi Casein kinase II, alpha chain 0.0146 0.0178 0.1432
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0237 0.0301 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0007 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0011 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.0257 0.1368
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0051 0.0048 0.029
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0931 0.1243 1
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0007 0.0071
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0107 0.0107
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0007 0.0037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.039 0.0509 0.4058
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0011 0.0087
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0007 0.0007
Trypanosoma brucei Casein kinase II 0.0146 0.0178 0.198
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.039 0.0509 0.4092
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0053 0.0373
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0026 0.0026
Onchocerca volvulus 0.0107 0.0125 0.2805
Giardia lamblia Kinase, PLK 0.0205 0.0257 0.279
Plasmodium vivax hypothetical protein, conserved 0.014 0.017 0.5303
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.003 0.0079
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0039 0.0032 0.0082
Leishmania major hypothetical protein, conserved 0.0037 0.003 0.0075
Loa Loa (eye worm) phosphatidylinositol 3 0.0674 0.0895 0.5344

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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