Detailed information for compound 88762

Basic information

Technical information
  • TDR Targets ID: 88762
  • Name: 4-naphthalen-1-ylnaphthalene-1,2-dione
  • MW: 284.308 | Formula: C20H12O2
  • H donors: 0 H acceptors: 2 LogP: 3.91 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=O)C=C(c2c1cccc2)c1cccc2c1cccc2
  • InChi: 1S/C20H12O2/c21-19-12-18(16-9-3-4-10-17(16)20(19)22)15-11-5-7-13-6-1-2-8-14(13)15/h1-12H
  • InChiKey: XHMKEYZGWVBFJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-naphthyl)naphthalene-1,2-dione
  • 4-(1-naphthalenyl)naphthalene-1,2-dione
  • 4-(1-naphthyl)-1,2-naphthoquinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Protein-tyrosine phosphatase containing protein Get druggable targets OG5_133865 All targets in OG5_133865
Loa Loa (eye worm) protein-tyrosine phosphatase Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus multilocularis tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum expressed protein Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus granulosus tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0251 0.4137 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.0651 0.0881
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Schistosoma mansoni protein tyrosine phosphatase 0.0011 0.0036 0.005
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0093 0.0106
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Trichomonas vaginalis set domain proteins, putative 0.0251 0.4137 0.4116
Brugia malayi hypothetical protein 0.0011 0.0036 0.0009
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0291 0.0407
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0407 0.0373
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1641 0.2296
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0403 0.0683
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0093 0.0106
Echinococcus multilocularis transient receptor potential gamma protein 0.0013 0.0072 0.0101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Echinococcus multilocularis GPCR, family 2 0.0066 0.0982 0.1374
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.0072 0.0101
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0013 0.0072 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0013 0.0072 0.0592
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Giardia lamblia Hexose transporter 0.0015 0.0104 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0843 0.1595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Onchocerca volvulus 0.0015 0.0104 0.0167
Schistosoma mansoni sugar transporter 0.0015 0.0104 0.0146
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.0072 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0982 0.1374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Echinococcus granulosus voltage dependent calcium channel 0.0013 0.0072 0.0101
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0011 0.0036 0.005
Onchocerca volvulus 0.0015 0.0104 0.0167
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0192 0.021
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0252 0.3514
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0072 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0982 0.1354
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0407 0.604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0262 0.0227
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus granulosus chromobox protein 1 0.0147 0.2352 0.3291
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Echinococcus multilocularis sodium leak channel non selective protein 0.0013 0.0072 0.0101
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0104 0.1114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0262 0.0227
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0072 0.0101
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0156 0.2517 0.3534
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1254 0.1223
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Echinococcus multilocularis solute carrier family 22 0.0015 0.0104 0.0146
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 0.0036 0.005
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0093 0.0926
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Brugia malayi cytochrome P450 0.0014 0.0093 0.009
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.013 0.1523
Echinococcus multilocularis calcium activated potassium channel 0.0015 0.0106 0.0149
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0013 0.0072 0.0101
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0072 0.0101
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0072 0.0101
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.04 0.0525
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0367 0.0513
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0013 0.0072 0.0592
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.013 0.1523
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0595 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0013 0.0072 0.0101
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.013 0.0119
Trichomonas vaginalis chromobox protein, putative 0.0147 0.2352 0.2325
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0072 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.3618 0.5099
Entamoeba histolytica protein kinase, putative 0.0032 0.04 0.0366
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.04 0.5926
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0011 0.0036 0.0006
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0072 0.0101
Leishmania major hypothetical protein, conserved 0.0015 0.0104 0.1114
Brugia malayi Protein-tyrosine phosphatase 0.0011 0.0036 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Brugia malayi hypothetical protein 0.0013 0.0072 0.0061
Loa Loa (eye worm) sugar transporter 0.0105 0.1641 0.2288
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0072 0.0101
Schistosoma mansoni two-pore calcium channel 0.0013 0.0072 0.0101
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1641 0.3246
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.013 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0403 0.0531
Loa Loa (eye worm) heterochromatin protein 1 0.0147 0.2352 0.3299
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.013 0.0034
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0093 0.0926
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0013 0.0072 0.0101
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0481 0.7229
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0262 0.0227
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0262 0.0367
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0252 0.3514
Toxoplasma gondii sugar transporter ST1 0.0015 0.0104 0.0066
Loa Loa (eye worm) protein tyrosine phosphatase 0.0011 0.0036 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0403 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0013 0.0072 0.0061
Echinococcus multilocularis short transient receptor potential channel 6 0.0013 0.0072 0.0101
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0478 0.084
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0401 0.0404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Loa Loa (eye worm) calcium channel 0.0013 0.0072 0.0058
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.013 0.0034
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0252 0.0201
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0262 0.0331
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0011 0.0036 0.0006
Schistosoma mansoni hypothetical protein 0.0024 0.0262 0.0367
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0403 0.0563
Echinococcus multilocularis voltage dependent calcium channel 0.0013 0.0072 0.0101
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Echinococcus granulosus voltage dependent calcium channel 0.0013 0.0072 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0104 0.0069
Brugia malayi SET domain containing protein 0.0026 0.0293 0.0375
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0036 0.005
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.7066 0.9884
Schistosoma mansoni protein tyrosine phosphatase 0.0011 0.0036 0.005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0481 0.0446
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0262 0.0393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.3118 0.4362
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0072 0.0101
Echinococcus multilocularis 0.0014 0.0093 0.013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0013 0.0072 0.0061
Schistosoma mansoni transient receptor potential channel 0.0013 0.0072 0.0101
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.013 0.0143
Schistosoma mansoni transient receptor potential channel 4 0.0013 0.0072 0.0101
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0104 0.1114
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0291 0.0407
Plasmodium vivax SET domain protein, putative 0.0032 0.0403 0.0406
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Toxoplasma gondii sugar transporter ST2 0.0015 0.0104 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) voltage-gated calcium channel 0.0013 0.0072 0.0058
Mycobacterium ulcerans sugar transporter 0.0015 0.0104 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3118 0.4362
Echinococcus multilocularis chromobox protein 2 0.0024 0.0262 0.0367
Brugia malayi major facilitator superfamily protein 0.0015 0.0104 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0651 0.0745
Schistosoma mansoni calcium-activated potassium channel 0.0013 0.0072 0.0101
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0203 0.0168
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0072 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0812 0.1135
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0011 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Entamoeba histolytica hypothetical protein 0.0024 0.0262 0.0227
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0481 0.0672
Schistosoma mansoni chromobox protein 0.0024 0.0262 0.0367
Brugia malayi Sugar transporter family protein 0.0015 0.0104 0.0107
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0093 0.0106
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0291 0.481 1
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0011 0.0036 0.0009
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Leishmania major glucose transporter, lmgt2 0.0033 0.0407 0.604
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0093 0.0106
Brugia malayi Pre-SET motif family protein 0.0221 0.3618 0.51
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1877 0.3782
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0072 0.0037
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0072 0.0101
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0072 0.0101
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Onchocerca volvulus 0.003 0.0365 0.0803
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0481 0.0672
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.7066 0.9884
Schistosoma mansoni voltage-dependent calcium channel 0.0013 0.0072 0.0101
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.013 0.0034
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0481 0.0672
Brugia malayi cation channel family protein 0.0013 0.0072 0.0061
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.1308
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0013 0.0072 0.0058
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Brugia malayi CXXC zinc finger family protein 0.003 0.0365 0.0477
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0093 0.0106
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0013 0.0072 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Schistosoma mansoni protein tyrosine phosphatase 0.0011 0.0036 0.005
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0072 0.0101
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0013 0.0072 0.0101
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Echinococcus granulosus solute carrier family 22 0.0015 0.0104 0.0146
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0262 0.0227
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Echinococcus multilocularis shaker cognate 0.0013 0.0072 0.0101
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0104 0.013
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0013 0.0072 0.0101
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0072 0.0101
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0252 0.0317
Leishmania major hypothetical protein, unknown function 0.0013 0.0072 0.0592
Schistosoma mansoni transient receptor potential channel 0.0013 0.0072 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0013 0.0072 0.0101
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0072 0.0101
Onchocerca volvulus Putative transporter 0.0015 0.0104 0.0167
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0093 0.0926
Schistosoma mansoni sugar transporter 0.0015 0.0104 0.0146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.3118 0.4388
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0072 0.0101
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0389 0.0545
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0407 0.0373
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0072 0.0101
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0013 0.0072 0.0061
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0192 0.021
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0013 0.0072 0.0061
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0104 0.1114
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0262 0.0367
Brugia malayi voltage-dependent calcium channel 0.0013 0.0072 0.0061
Schistosoma mansoni 60S ribosomal protein L21 0.0013 0.0072 0.0101
Brugia malayi hypothetical protein 0.0011 0.0036 0.0009
Trypanosoma brucei sugar transporter, putative 0.0015 0.0104 0.1114
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0262 0.0331
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0072 0.0101
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0013 0.0072 0.0101
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0389 0.0545
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0072 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0403 0.0563
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.013 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0104 0.0146
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0072 0.0101
Schistosoma mansoni transient receptor potential channel 0.0013 0.0072 0.0101
Schistosoma mansoni chromobox protein 0.0024 0.0262 0.0367
Loa Loa (eye worm) hypothetical protein 0.0082 0.1254 0.1738
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Onchocerca volvulus 0.0015 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0401 0.0404
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0093 0.0106
Echinococcus multilocularis transfer RNA-Gly 0.0013 0.0072 0.0101
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0478 0.7191
Schistosoma mansoni pcd6 interacting protein-related 0.0011 0.0036 0.005
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.7066 0.9884
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0389 0.0545
Schistosoma mansoni hypothetical protein 0.0143 0.2292 0.3207
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0262 0.0331
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0481 0.0446
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0389 0.0512
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0478 0.7191
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0011 0.0036 0.0009
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0104 0.0146
Brugia malayi Transient-receptor-potential like protein 0.0013 0.0072 0.0061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.04 0.056
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0104 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0407 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1254 0.1223
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0389 0.0629
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0845 0.0812
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0104 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0073 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0845 0.0812
Entamoeba histolytica hypothetical protein 0.0024 0.0262 0.0227
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0013 0.0072 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3118 0.4362
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0262 0.0215
Loa Loa (eye worm) hypothetical protein 0.0031 0.0389 0.0509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.3118 0.4362
Leishmania major glucose transporter, lmgt3 0.0033 0.0407 0.604
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0982 0.1352
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1877 0.3782
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0478 0.051
Entamoeba histolytica hypothetical protein 0.0024 0.0262 0.0227
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0478 0.7191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0378 0.0343
Schistosoma mansoni glucose transport protein 0.0105 0.1641 0.2296
Schistosoma mansoni cpg binding protein 0.0032 0.0394 0.0552
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0072 0.0101
Brugia malayi Protein-tyrosine phosphatase 0.0011 0.0036 0.0009
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0252 0.0372
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0291 0.481 1
Echinococcus multilocularis muscleblind protein 0.0156 0.2517 0.3521
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0072 0.0101
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0407 0.604
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0104 0.0146
Schistosoma mansoni chromobox protein 0.0147 0.2352 0.3291
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0401 0.0404
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0013 0.0072 0.0592
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus multilocularis ryanodine receptor 44f 0.0013 0.0073 0.0102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0324 0.029
Onchocerca volvulus 0.0015 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0093 0.0087
Schistosoma mansoni glucose transporter 0.0015 0.0104 0.0146
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0372 0.052
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0013 0.0072 0.0061
Brugia malayi ion channel NompC 0.0013 0.0072 0.0061
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0389 0.0355
Echinococcus multilocularis chromobox protein 1 0.0147 0.2352 0.3291
Echinococcus granulosus protein tyrosine phosphatase n9 0.0011 0.0036 0.005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Loa Loa (eye worm) voltage-dependent calcium channel 0.0013 0.0072 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0013 0.0072 0.0101
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0072 0.0101
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0401 0.068
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0036 0.005
Schistosoma mansoni voltage-gated cation channel 0.0013 0.0072 0.0101
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0013 0.0072 0.0592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0013 0.0072 0.0061
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.2742 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0252 0.0217
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0252 0.3514
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0011 0.0036 0.005
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.0072 0.0101
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0072 0.0101
Echinococcus granulosus calcium activated potassium channel 0.0015 0.0106 0.0149
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0262 0.0215
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0072 0.0101
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0262 0.0367
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0093 0.0106
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0013 0.0073 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0481 0.0642
Echinococcus multilocularis muscleblind protein 1 0.0156 0.2517 0.3521
Schistosoma mansoni hypothetical protein 0.0066 0.0982 0.1374
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0013 0.0072 0.0101
Schistosoma mansoni cpg binding protein 0.003 0.0365 0.0511
Onchocerca volvulus 0.0013 0.0072 0.0089
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0407 0.604
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0401 0.068
Onchocerca volvulus 0.0015 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0011 0.0036 0.005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.3421 0.4821
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0252 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.0651 0.0745
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0104 0.0104
Echinococcus multilocularis cpg binding protein 0.0032 0.0394 0.0552
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Brugia malayi MH2 domain containing protein 0.0119 0.1879 0.2629
Plasmodium falciparum protein kinase 7 0.0296 0.4905 0.6542
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0093 0.0106
Schistosoma mansoni glucose transport protein 0.0105 0.1641 0.2296
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0262 0.0227
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0072 0.0101
Echinococcus multilocularis short transient receptor potential channel 6 0.0013 0.0072 0.0101
Echinococcus multilocularis General substrate transporter 0.009 0.139 0.1944
Treponema pallidum NADH oxidase 0.0016 0.013 0.0087
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0093 0.0926
Trichomonas vaginalis chromobox protein, putative 0.0088 0.136 0.1329
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0011 0.0036 0.005
Echinococcus granulosus sodium leak channel non selective protein 0.0013 0.0072 0.0101
Echinococcus granulosus ryanodine receptor 44f 0.0013 0.0073 0.0102
Echinococcus granulosus TRP transient receptor potential channel 0.0013 0.0072 0.0101
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0982 0.1374
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Schistosoma mansoni cytochrome P450 0.0014 0.0093 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.2292 0.3216
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.3421 0.4821
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0013 0.0072 0.0101
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0389 0.0355
Loa Loa (eye worm) hypothetical protein 0.0023 0.0252 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3118 0.4362
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0407 0.604
Schistosoma mansoni vesicular amine transporter 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0389 0.0509
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0032 0.04 0.0525
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0262 0.0215
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.2517 0.3534
Echinococcus granulosus chromobox protein 1 0.0147 0.2352 0.3291
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.2742 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0013 0.0072 0.0089
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0013 0.0072 0.0101
Echinococcus granulosus sodium channel protein 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0143 0.2292 0.3214
Echinococcus granulosus short transient receptor potential channel 6 0.0013 0.0072 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus granulosus GPCR family 2 0.0066 0.0982 0.1374
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0093 0.0087
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0262 0.0393
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Brugia malayi glutathione reductase 0.0047 0.0651 0.0884
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0036 0.005
Echinococcus granulosus short transient receptor potential channel 6 0.0013 0.0072 0.0101
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.0072 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0093 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Brugia malayi hypothetical protein 0.0015 0.0104 0.0107
Onchocerca volvulus 0.0015 0.0104 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0104 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0651 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1879 0.2627
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0011 0.0036 0.0006
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0407 0.604
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0478 0.051
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1674 0.3352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0093 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1674 0.3352
Schistosoma mansoni sugar transporter 0.0015 0.0104 0.0146
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0036 0.005
Schistosoma mansoni cpg binding protein 0.0032 0.0394 0.0552
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0104 0.0107
Loa Loa (eye worm) hypothetical protein 0.0037 0.0481 0.0639
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0013 0.0072 0.0101
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0104 0.0069
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0056 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0104 0.0069
Giardia lamblia Sugar-proton symporter 0.0015 0.0104 0.0069
Brugia malayi Cytochrome P450 family protein 0.0014 0.0093 0.009
Echinococcus granulosus cpg binding protein 0.0032 0.0394 0.0552
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0072 0.0101
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0072 0.0101
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0252 0.044
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.0072 0.0101
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0481 0.0672
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0407 0.604
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0365 0.0475
Brugia malayi Cyclic-nucleotide gated cation channel 0.0013 0.0072 0.0061
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0093 0.0042
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0093 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1641 0.1611
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0072 0.0101
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Schistosoma mansoni hypothetical protein 0.0105 0.1641 0.2296
Schistosoma mansoni protein kinase 0.0032 0.04 0.056
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Trypanosoma cruzi hexose transporter 0.0033 0.0407 0.604
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0011 0.0036 0.005
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0072 0.0101
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1877 0.3782
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0013 0.0072 0.0101
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.013 0.1523
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Trypanosoma brucei trypanothione reductase 0.0047 0.0651 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0013 0.0072 0.0101
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0036 0.005
Loa Loa (eye worm) helicase 0.0024 0.0262 0.0328
Schistosoma mansoni voltage-gated ion channel 0.0013 0.0072 0.0101
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.04 0.0528
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.013 0.0078
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0072 0.0101
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0481 0.0446
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0407 0.0373
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Brugia malayi Muscleblind-like protein 0.0156 0.2517 0.3536
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0478 0.7191
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0013 0.0072 0.0061
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0011 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Onchocerca volvulus 0.0015 0.0104 0.0167
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0011 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Onchocerca volvulus 0.0056 0.0812 0.1892
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Echinococcus multilocularis 0.0011 0.0036 0.005
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0072 0.0061
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0072 0.0058
Entamoeba histolytica hypothetical protein 0.0023 0.0252 0.0217
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0403 0.0563
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0104 0.0146
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0389 0.0545
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0401 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0011 0.0036 0.005
Schistosoma mansoni protein kinase 0.0032 0.04 0.056
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0093 0.0106
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0291 0.481 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0013 0.0072 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Onchocerca volvulus 0.0015 0.0104 0.0167
Onchocerca volvulus 0.0024 0.0262 0.0552
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0401 0.068
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0104 0.013
Plasmodium falciparum protein kinase 6 0.0445 0.7442 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Echinococcus granulosus solute carrier family 22 0.0015 0.0104 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0403 0.0528
Trypanosoma brucei glucose transporter 1E 0.0033 0.0407 0.604
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.7149 1
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0072 0.0101
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0262 0.0227
Loa Loa (eye worm) hypothetical protein 0.0026 0.0289 0.0366
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0252 0.0217
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0013 0.0072 0.0101
Echinococcus granulosus transient receptor potential gamma protein 0.0013 0.0072 0.0101
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1674 0.3352
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Echinococcus multilocularis solute carrier family 22 0.0015 0.0104 0.0146
Echinococcus multilocularis voltage dependent calcium channel 0.0013 0.0072 0.0101
Onchocerca volvulus 0.0015 0.0104 0.0167
Toxoplasma gondii thioredoxin reductase 0.0047 0.0651 0.1198
Echinococcus multilocularis hypothetical protein 0.0011 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0056 0.0038
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0262 0.0367
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0478 0.7191
Onchocerca volvulus 0.0015 0.0104 0.0167
Brugia malayi Protein-tyrosine phosphatase 1 0.0011 0.0036 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.04 0.0366
Leishmania major protein kinase, putative 0.0032 0.04 0.5926
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0252 0.0353
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Onchocerca volvulus 0.0015 0.0104 0.0167
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0291 0.0407
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0324 0.029
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0072 0.0101
Mycobacterium tuberculosis Probable reductase 0.0107 0.1674 0.3352
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0072 0.0101
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0252 0.0338
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0013 0.0072 0.0061
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0093 0.0926
Echinococcus multilocularis sodium channel protein 0.0013 0.0072 0.0101
Echinococcus granulosus shaker cognate 0.0013 0.0072 0.0101
Echinococcus multilocularis two pore calcium channel protein 2 0.0013 0.0072 0.0101
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0252 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Echinococcus granulosus muscleblind protein 0.0156 0.2517 0.3521
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0401 0.0404
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 0.0036 0.005
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0011 0.0036 0.005
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0104 0.0146
Echinococcus multilocularis potassium large conductance calcium activated 0.0013 0.0072 0.0101
Plasmodium falciparum thioredoxin reductase 0.0047 0.0651 0.0745
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0378 0.0343
Leishmania major cytochrome p450-like protein 0.0014 0.0093 0.0926
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.013 0.0183
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1674 0.3352
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0481 0.7229
Loa Loa (eye worm) sugar transporter 0.0015 0.0104 0.0104
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0252 0.0201
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0072 0.0101
Brugia malayi Cytochrome P450 family protein 0.0014 0.0093 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0378 0.0343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.3421 0.4819
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.013 0.1523
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0481 0.7229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Brugia malayi hypothetical protein 0.0011 0.0036 0.0009
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0013 0.0072 0.0061
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0481 0.0672
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0011 0.0036 0.005
Brugia malayi Heterochromatin protein 1 0.0147 0.2352 0.3301
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0013 0.0072 0.0089
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0093 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.3118 0.4362
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Schistosoma mansoni hypothetical protein 0.0066 0.0982 0.1374
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0093 0.013
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0013 0.0072 0.0101
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0481 0.7229
Treponema pallidum fructose-bisphosphate aldolase 0.0595 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0011 0.0036 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 1 1
Onchocerca volvulus 0.0024 0.0262 0.0552
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0011 0.0036 0.005
Plasmodium falciparum hexose transporter 0.0105 0.1641 0.2094
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0407 0.0373
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0192 0.021
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.013 0.0094
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0104 0.0066
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0093 0.0106
Entamoeba histolytica protein kinase, putative 0.0032 0.04 0.0366
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0156 0.1954
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0104 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.013 1
Leishmania major trypanothione reductase 0.0047 0.0651 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0011 0.0036 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0403 0.0563
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.013 0.1523
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0013 0.0072 0.0101
Echinococcus granulosus hypothetical protein 0.0013 0.0072 0.0101
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0072 0.0101
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0013 0.0072 0.0592
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.013 0.0183
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0072 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1674 0.3352
Echinococcus granulosus Chromobox protein 3 0.0024 0.0262 0.0367
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0072 0.0101
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0093 0.0106
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0013 0.0072 0.0101
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0104 0.1114
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0262 0.0215
Loa Loa (eye worm) ryanodine receptor 0.0013 0.0072 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0262 0.0227
Brugia malayi Sugar transporter family protein 0.0105 0.1641 0.2291
Brugia malayi cation channel family protein 0.0013 0.0072 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0104 0.0069
Loa Loa (eye worm) voltage-gated potassium channel 0.0013 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0072 0.0101
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0104 0.013
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0481 0.0446
Brugia malayi Sugar transporter family protein 0.0015 0.0104 0.0107
Leishmania major cytochrome p450-like protein 0.0014 0.0093 0.0926
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.013 0.4156
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0093 0.0926
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) hypothetical protein 0.0024 0.0262 0.0328
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Onchocerca volvulus 0.0064 0.0951 0.2232
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0651 0.0881
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0651 0.0911
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.1254 0.2971
Schistosoma mansoni hypothetical protein 0.0013 0.0072 0.0101
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0651 0.0911
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0982 0.1354
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0011 0.0036 0.005
Schistosoma mansoni sugar transporter 0.0015 0.0104 0.0146
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0072 0.0101
Schistosoma mansoni glucose transport protein 0.0105 0.1641 0.2296
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0013 0.0072 0.0101
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0031 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Plasmodium falciparum glutathione reductase 0.0016 0.013 0.0034
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0093 0.0926
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0072 0.0058
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Echinococcus multilocularis Chromo domain 0.0024 0.0262 0.0367
Brugia malayi chromobox protein homolog 3 0.0082 0.1254 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0407 0.0373
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0104 0.0104
Onchocerca volvulus 0.0015 0.0104 0.0167
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0481 0.0672
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0481 0.0672
Schistosoma mansoni protein kinase 0.0032 0.04 0.056
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0403 0.0563
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0013 0.0072 0.0101
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0104 0.0107
Plasmodium vivax hexose transporter 0.0105 0.1641 0.2094
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0072 0.0101
Brugia malayi Cytochrome P450 family protein 0.0014 0.0093 0.009
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0093 0.0926
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0093 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0011 0.0036 0.005
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0262 0.0227
Brugia malayi hypothetical protein 0.0011 0.0036 0.0009
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.2742 0.5525
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0013 0.0072 0.0101
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0013 0.0072 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0104 0.0069
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.013 0.1523
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Onchocerca volvulus 0.0015 0.0104 0.0167
Onchocerca volvulus 0.0015 0.0104 0.0167
Echinococcus granulosus solute carrier family 22 0.0015 0.0104 0.0146
Echinococcus multilocularis two pore calcium channel protein 1 0.0013 0.0072 0.0101
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.013 0.0094
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0011 0.0036 0.005
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0367 0.0513
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0013 0.0072 0.0061
Brugia malayi Protein cec-1. 0.0024 0.0262 0.0331
Onchocerca volvulus 0.0015 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0093 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0378 0.0343
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0401 0.0404
Schistosoma mansoni hypothetical protein 0.0014 0.0093 0.013
Schistosoma mansoni hypothetical protein 0.0066 0.0982 0.1374
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0401 0.0404
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0072 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0104 0.0069
Brugia malayi CHD4 protein 0.0026 0.0291 0.0372
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0147 0.2352 0.2325
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0407 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.04 0.056
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0104 0.0069
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0013 0.0072 0.0101
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0481 0.0672
Plasmodium falciparum glutathione reductase 0.0047 0.0651 0.0745
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.3118 0.439
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Brugia malayi Cytochrome P450 family protein 0.0014 0.0093 0.009
Leishmania major glucose transporter, lmgt1 0.0033 0.0407 0.604
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0982 0.1374
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0262 0.0367
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0072 0.0101
Echinococcus multilocularis chromobox protein 1 0.0147 0.2352 0.3291
Brugia malayi hypothetical protein 0.0015 0.0104 0.0107
Echinococcus granulosus potassium large conductance calcium activated 0.0013 0.0072 0.0101
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0013 0.0072 0.0101
Echinococcus granulosus two pore calcium channel protein 1 0.0013 0.0072 0.0101
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0072 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0262 0.0227
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0401 0.0404
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0262 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0378 0.0343
Brugia malayi Thioredoxin reductase 0.0047 0.0651 0.0884
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0378 0.0343
Echinococcus multilocularis solute carrier family 22 0.0015 0.0104 0.0146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Trypanosoma brucei glucose transporter, putative 0.0033 0.0407 0.604
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0291 0.037
Brugia malayi olfactory channel protein osm-9 0.0013 0.0072 0.0061
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0093 0.0087
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.136 0.323
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0011 0.0036 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0378 0.0343
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.0072 0.0101
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.7066 1
Toxoplasma gondii protein kinase, putative 0.0296 0.4905 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0262 0.0367
Loa Loa (eye worm) cytochrome P450 0.0014 0.0093 0.0087
Loa Loa (eye worm) hypothetical protein 0.0066 0.0982 0.1352
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0959 0.1342
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0072 0.0101
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.013 0.0181
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Plasmodium falciparum thioredoxin reductase 0.0016 0.013 0.0034
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0262 0.0393
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0031 0.0044
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0072 0.0101
Trichomonas vaginalis hypothetical protein 0.0024 0.0262 0.0227
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0262 0.0215
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0401 0.0404
Echinococcus multilocularis solute carrier family 22 0.0015 0.0104 0.0146
Trypanosoma brucei glucose transporter 2A 0.0033 0.0407 0.604
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0252 0.0353
Echinococcus granulosus voltage gated hydrogen channel 1 0.0013 0.0072 0.0101
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.013 0.1523
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0104 0.1114
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.013 0.0181
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1641 0.2296
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0982 0.1374
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 0.0036 0.0009
Brugia malayi hypothetical protein 0.0015 0.0104 0.0107
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0072 0.0101
Loa Loa (eye worm) ion channel NompC 0.0013 0.0072 0.0058
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1674 0.3352
Trichomonas vaginalis chromobox protein, putative 0.0088 0.136 0.1329
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0011 0.0036 0.005
Toxoplasma gondii sugar transporter ST3 0.0015 0.0104 0.0066
Brugia malayi hypothetical protein 0.0011 0.0036 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0262 0.0227
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1877 0.3782
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0262 0.0331
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.3118 0.4362
Giardia lamblia Fructose-bisphosphate aldolase 0.0595 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.7066 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Echinococcus granulosus chromobox protein 2 0.0024 0.0262 0.0367
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.04 0.0525
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0006
Schistosoma mansoni ryanodine receptor related 0.0013 0.0073 0.0102
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 0.0036 0.005
Onchocerca volvulus 0.0015 0.0104 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Brugia malayi hypothetical protein 0.0024 0.0262 0.0331
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.013 0.1523
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0389 0.0512
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0252 0.0353
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Leishmania major cytochrome p450-like protein 0.0014 0.0093 0.0926
Loa Loa (eye worm) voltage-gated potassium channel 0.0013 0.0072 0.0058
Plasmodium vivax CDK-related protein kinase 6, putative 0.0445 0.7442 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0058
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0389 0.0355
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0407 0.604
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0104 0.0069
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0093 0.0106
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0252 0.044
Loa Loa (eye worm) hypothetical protein 0.0209 0.3421 0.4819
Echinococcus granulosus two pore calcium channel protein 2 0.0013 0.0072 0.0101
Brugia malayi Cam kinase protein 1 0.0032 0.04 0.0528
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0316 0.0281
Schistosoma mansoni hypothetical protein 0.0428 0.7149 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0651 0.1184
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.013 0.0094
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0036 0.005
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 0.0036 0.005
Schistosoma mansoni chromobox protein 0.0147 0.2352 0.3291
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.013 0.0183
Brugia malayi major facilitator superfamily protein 0.0015 0.0104 0.0107
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0036 0.0006
Echinococcus granulosus General substrate transporter 0.009 0.139 0.1944
Echinococcus granulosus solute carrier family 22 0.0015 0.0104 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0378 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.1523
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.013 0.1523
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1879 0.2627
Echinococcus granulosus dnaJ subfamily B 0.0428 0.7149 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0093 0.0106
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.0072 0.0101
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0011 0.0036 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0262 0.0215
Echinococcus granulosus Chromo domain 0.0024 0.0262 0.0367
Leishmania major hypothetical protein, conserved 0.0013 0.0072 0.0592
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0011 0.0036 0.005
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0093 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0481 0.0446
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.013 0.0034
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0072 0.0101
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.04 0.056
Schistosoma mansoni hypothetical protein 0.0066 0.0982 0.1374

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.15 uM In vitro inhibitory activity against recombinant human protein-tyrosine phosphatase 1B (PTP1B) using fluoreacein diphosphate (FDP) as a substrate ChEMBL. 12113814
IC50 (binding) = 2.15 uM In vitro inhibitory activity against recombinant human protein-tyrosine phosphatase 1B (PTP1B) using fluoreacein diphosphate (FDP) as a substrate ChEMBL. 12113814

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.