Detailed information for compound 914247

Basic information

Technical information
  • TDR Targets ID: 914247
  • Name: (3R)-3-amino-1-(2-benzoyldiazepan-1-yl)-4-(2, 4,5-trifluorophenyl)butan-1-one hydrochloride
  • MW: 455.901 | Formula: C22H25ClF3N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCCCCN1C(=O)c1ccccc1.Cl
  • InChi: 1S/C22H24F3N3O2.ClH/c23-18-14-20(25)19(24)12-16(18)11-17(26)13-21(29)27-9-5-2-6-10-28(27)22(30)15-7-3-1-4-8-15;/h1,3-4,7-8,12,14,17H,2,5-6,9-11,13,26H2;1H/t17-;/m1./s1
  • InChiKey: YWYAWJIMMUVLHJ-UNTBIKODSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R)-3-amino-1-(2-benzoyl-1-diazepanyl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride
  • (3R)-3-amino-1-[2-(phenylcarbonyl)-1,2-diazepan-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Dipeptidyl peptidase IV Starlite/ChEMBL References
Homo sapiens dipeptidyl-peptidase 7 Starlite/ChEMBL References
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Lysosomal Pro X carboxypeptidase Get druggable targets OG5_139351 All targets in OG5_139351
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase Get druggable targets OG5_139351 All targets in OG5_139351
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative Get druggable targets OG5_139351 All targets in OG5_139351
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni family S28 unassigned peptidase (S28 family) Get druggable targets OG5_139351 All targets in OG5_139351
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Dipeptidyl peptidase IV   766 aa 799 aa 30.3 %
Echinococcus granulosus Dipeptidyl peptidase 9 Dipeptidyl peptidase IV   766 aa 661 aa 26.3 %
Candida albicans dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor Dipeptidyl peptidase IV   766 aa 807 aa 25.4 %
Leishmania braziliensis dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Dipeptidyl peptidase IV   766 aa 706 aa 24.6 %
Trypanosoma cruzi serine carboxypeptidase S28, putative dipeptidyl-peptidase 7 492 aa 471 aa 25.7 %
Onchocerca volvulus Dipeptidyl peptidase IV   766 aa 646 aa 26.9 %
Echinococcus multilocularis Dipeptidyl peptidase 9 Dipeptidyl peptidase IV   766 aa 614 aa 25.2 %
Dictyostelium discoideum hypothetical protein Dipeptidyl peptidase IV   766 aa 672 aa 25.6 %
Candida albicans dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor Dipeptidyl peptidase IV   766 aa 807 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0116 0.0327
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0039 0.0141
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0212 0.0602
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Brugia malayi Endochitinase 0.0136 0.0257 0.1001
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0208 0.0803
Brugia malayi beta-lactamase 0.0113 0.0208 0.0812
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0136 0.0257 0.1001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0099 0.0387
Echinococcus multilocularis protein patched 0.0208 0.0406 0.0404
Onchocerca volvulus 0.0062 0.0099 0.0307
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0116 0.0444
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0062 0.0099 0.0378
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0048 0.0177
Loa Loa (eye worm) hypothetical protein 0.0157 0.03 0.1169
Loa Loa (eye worm) microfilarial chitinase 0.0902 0.1867 0.7286
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Plasmodium vivax chitinase 0.0136 0.0257 0.0993
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0208 0.2133
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0054 0.0819
Onchocerca volvulus 0.0029 0.0031 0.004
Echinococcus granulosus neuropeptide s receptor 0.0901 0.1867 0.5353
Brugia malayi RNA binding protein 0.0133 0.025 0.0974
Brugia malayi isocitrate dehydrogenase 0.0016 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0062 0.0099 0.3675
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.005 0.0419
Echinococcus multilocularis dna polymerase eta 0.002 0.0011 0.0009
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0042 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0085
Echinococcus granulosus dna polymerase kappa 0.002 0.0011 0.0026
Trypanosoma cruzi FHA domain containing protein, putative 0.0038 0.005 0.1806
Schistosoma mansoni cpg binding protein 0.0032 0.0036 0.0133
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0208 0.1214
Loa Loa (eye worm) hypothetical protein 0.0244 0.0482 0.1882
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0054 0.021
Schistosoma mansoni nuclear receptor 0.0033 0.0039 0.0141
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0062 0.0099 0.0593
Brugia malayi conserved hypotetical protein 0.0033 0.0039 0.0151
Brugia malayi endochitinase 0.0926 0.192 0.7489
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0142 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0039 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Schistosoma mansoni tar DNA-binding protein 0.0133 0.025 0.0965
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0062 0.0099 0.0593
Toxoplasma gondii ATPase, AAA family protein 0.0038 0.005 0.0186
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0054 0.0223
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0054 0.0462
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0025 0.0021 0.0105
Brugia malayi AMP-binding enzyme family protein 0.021 0.0411 0.1605
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Brugia malayi Patched related family protein 12 0.0029 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0195
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0169 0.0661
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0047 0.0174
Echinococcus granulosus GPCR family 2 0.0077 0.0132 0.0371
Plasmodium falciparum conserved protein, unknown function 0.1232 0.2563 1
Brugia malayi Patched protein homolog 1 0.0029 0.0031 0.0122
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0047 0.0183
Onchocerca volvulus Protein patched homolog 0.0029 0.0031 0.004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0116 0.0453
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0456 0.093 0.3623
Mycobacterium tuberculosis Conserved protein 0.0113 0.0208 0.1261
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0025 0.0021 0.0073
Echinococcus multilocularis neuropeptide s receptor 0.0901 0.1867 0.1865
Loa Loa (eye worm) hypothetical protein 0.0062 0.0099 0.0387
Echinococcus granulosus Dipeptidyl peptidase 9 0.0141 0.0266 0.0755
Loa Loa (eye worm) hypothetical protein 0.0254 0.0504 0.1968
Leishmania major pyruvate kinase 0.0032 0.0037 0.0181
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0037 0.0145
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.0157 0.03 0.1169
Brugia malayi hypothetical protein 0.0038 0.005 0.0195
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0208 0.0406 0.1585
Brugia malayi Niemann-Pick C1 protein precursor 0.0484 0.0987 0.3852
Onchocerca volvulus 0.003 0.0033 0.0046
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0208 0.1261
Echinococcus granulosus smad 0.0016 0.0004 0.0004
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0062 0.0099 0.0378
Schistosoma mansoni hypothetical protein 0.02 0.039 0.1515
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0004 0.0007
Onchocerca volvulus Putative endochitinase 0.1038 0.2155 0.8394
Plasmodium vivax replication factor C subunit 1, putative 0.0038 0.005 0.0186
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0141 0.0266 1
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0021 0.0707
Brugia malayi Glycosyl hydrolases family 18 protein 0.0136 0.0257 0.1001
Brugia malayi Pax transcription activation domain interacting protein 0.0038 0.005 0.0195
Loa Loa (eye worm) hypothetical protein 0.0208 0.0406 0.1585
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0039 0.0144
Loa Loa (eye worm) TAR-binding protein 0.0133 0.025 0.0974
Schistosoma mansoni ets-related 0.0249 0.0494 0.192
Schistosoma mansoni DNA polymerase eta 0.002 0.0011 0.0035
Schistosoma mansoni hypothetical protein 0.02 0.039 0.1515
Echinococcus multilocularis Niemann Pick C1 protein 0.0484 0.0987 0.0985
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0062 0.0099 0.0593
Entamoeba histolytica chitinase, putative 0.0926 0.192 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0042 0.0338
Onchocerca volvulus Putative chitinase 0.0136 0.0257 0.0927
Onchocerca volvulus 0.0458 0.0933 0.3589
Echinococcus multilocularis replication factor c subunit 1 0.0038 0.005 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.021 0.0411 0.2467
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0044 0.0174
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0062 0.0099 0.3675
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0039 0.0144
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0031 0.0112
Echinococcus multilocularis dna polymerase kappa 0.002 0.0011 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0148 0.0282 0.1712
Trichomonas vaginalis antibiotic synthetase, putative 0.0062 0.0099 0.0952
Onchocerca volvulus 0.0027 0.0027 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0077 0.0132 0.0514
Echinococcus multilocularis pyruvate kinase 0.0017 0.0004 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0116 0.0374
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0039 0.0151
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0039 0.0146
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0172 0.0169
Brugia malayi jmjC domain containing protein 0.0096 0.0172 0.0669
Brugia malayi hypothetical protein 0.1173 0.2439 0.9516
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0283 0.1721
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0086 0.0241
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0001
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0062 0.0099 0.0593
Loa Loa (eye worm) hypothetical protein 0.0157 0.03 0.1169
Brugia malayi endochitinase 0.1038 0.2155 0.8407
Schistosoma mansoni alpha glucosidase 0.0035 0.0042 0.0156
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0108 0.0414
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Entamoeba histolytica hypothetical protein 0.0038 0.005 0.0202
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.0116 0.0327
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0077 0.0132 0.0129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0148 0.0282 0.1712
Schistosoma mansoni hypothetical protein 0.0077 0.0132 0.0505
Loa Loa (eye worm) hypothetical protein 0.021 0.0411 0.1605
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0208 0.1261
Loa Loa (eye worm) hypothetical protein 0.1232 0.2563 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0169 0.6344
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Mycobacterium ulcerans lipase LipD 0.0113 0.0208 0.1214
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0237 0.0469 0.2434
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0418 0.085 0.0848
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0005
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0062 0.0099 0.3675
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0039 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0103
Mycobacterium ulcerans beta-lactamase 0.0113 0.0208 0.1214
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.005 0.1806
Plasmodium vivax patched family protein, putative 0.0029 0.0031 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0048 0.0177
Brugia malayi hypothetical protein 0.0029 0.0031 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0116 0.0444
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0044
Echinococcus multilocularis cpg binding protein 0.0032 0.0036 0.0034
Giardia lamblia DINP protein human, muc B family 0.002 0.0011 0.0117
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0116 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0237 0.0469 0.2824
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0136 0.0257 0.0254
Toxoplasma gondii propionate-CoA ligase 0.0062 0.0099 0.0378
Schistosoma mansoni acetyl-CoA synthetase 0.0062 0.0099 0.0378
Giardia lamblia Kinase, PLK 0.0095 0.0169 0.2721
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.0299 0.0296
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0039 0.0141
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0116 0.0327
Mycobacterium ulcerans hypothetical protein 0.0113 0.0208 0.1214
Schistosoma mansoni inositol monophosphatase 0.0036 0.0044 0.0164
Loa Loa (eye worm) hypothetical protein 0.0113 0.0208 0.0812
Echinococcus multilocularis geminin 0.0171 0.0328 0.0326
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0015
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0418 0.085 0.3311
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0116 0.0453
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0037 0.0064
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0044 0.0164
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0011 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0116 0.0327
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0062 0.0099 0.3675
Onchocerca volvulus 0.0062 0.0099 0.0307
Schistosoma mansoni survival motor neuron protein 0.0239 0.0473 0.1838
Onchocerca volvulus 0.0113 0.0208 0.0736
Mycobacterium ulcerans PE-PGRS family protein 0.0136 0.0257 0.1513
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0005 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0054 0.0201
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Mycobacterium ulcerans chitinase/cellulase 0.079 0.1632 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0021 0.0105
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0077 0.0132 0.0514
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0039 0.0141
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0022 0.0737
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0047 0.0045
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0039 0.0037
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0038 0.005 0.5821
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0456 0.093 0.2663
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0013 0.0052
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0042 0.0156
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0042 0.0163
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0116 0.0453
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0116 0.0444
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0039 0.0577
Giardia lamblia PHD finger protein 15 0.0029 0.0031 0.0444
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.0112 0.0205 0.0798
Echinococcus granulosus intermediate filament protein 0.0027 0.0027 0.0069
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.021 0.0411 0.2508
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0021 0.0082
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0039 0.1398
Loa Loa (eye worm) hypothetical protein 0.0136 0.0257 0.1001
Echinococcus granulosus microtubule associated protein 2 0.067 0.138 0.3954
Loa Loa (eye worm) patched family protein 0.0029 0.0031 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.0237 0.0469 0.1822
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Trypanosoma cruzi oligopeptidase b 0.0033 0.0039 0.1398
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.021 0.0411 0.2467
Brugia malayi hypothetical protein 0.0136 0.0257 0.1001
Brugia malayi nuclear receptor NHR-67 0.0033 0.0039 0.0151
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0239 0.0473 0.1846
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Schistosoma mansoni coup transcription factor 0.007 0.0116 0.0444
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0022 0.0737
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0062 0.0099 0.0542
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0042 0.0166
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0037 0.0281
Schistosoma mansoni smad 0.0016 0.0004 0.0005
Entamoeba histolytica hypothetical protein 0.0115 0.0212 0.1052
Trypanosoma cruzi oligopeptidase b 0.0033 0.0039 0.1398
Echinococcus granulosus pyruvate kinase 0.0017 0.0004 0.0005
Toxoplasma gondii hypothetical protein 0.0033 0.0039 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0208 0.7814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0002 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0208 0.2133
Schistosoma mansoni pyruvate kinase 0.0032 0.0037 0.0136
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0039 0.0104
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0027 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0039 0.0106
Brugia malayi CXXC zinc finger family protein 0.003 0.0033 0.0128
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.0266 0.1036
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0112 0.0205 0.0798
Mycobacterium ulcerans acetyl-CoA synthetase 0.0062 0.0099 0.0542
Brugia malayi DKFZp564C0469 protein 0.0038 0.005 0.0195
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0011 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0015
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0037 0.1321
Schistosoma mansoni inositol monophosphatase 0.0036 0.0044 0.0164
Echinococcus multilocularis GPCR, family 2 0.0077 0.0132 0.0129
Loa Loa (eye worm) patched family protein 0.0029 0.0031 0.0122
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0116 0.0444
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.005 0.1806
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0092 0.035
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0038 0.005 0.0186
Toxoplasma gondii exonuclease III APE 0.004 0.0054 0.0201
Brugia malayi ecdysteroid receptor 0.007 0.0116 0.0453
Brugia malayi nuclear receptor NHR-88 0.007 0.0116 0.0453
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.0266 0.1028
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0099 0.0387
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0039 0.0151
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0283 0.6574
Leishmania major DNA polymerase eta, putative 0.002 0.0011 0.0046
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0141 0.0266 0.1373
Brugia malayi TAR-binding protein 0.0133 0.025 0.0974
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0169 0.0661
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Echinococcus multilocularis smad 0.0016 0.0004 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0208 0.0812
Brugia malayi hypothetical protein 0.0115 0.0212 0.0827
Onchocerca volvulus 0.0113 0.0208 0.0736
Onchocerca volvulus 0.009 0.016 0.0546
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0044 0.1597
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0062 0.0099 0.0387
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0011 0.0044
Mycobacterium tuberculosis Conserved protein 0.0113 0.0208 0.1261
Echinococcus multilocularis musashi 0.0027 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0039 0.0146
Schistosoma mansoni intermediate filament proteins 0.0027 0.0027 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0212 0.0819
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0116 0.0453
Brugia malayi hypothetical protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.0611 0.3143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0208 0.0812
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Loa Loa (eye worm) patched family protein 0.0029 0.0031 0.0122
Onchocerca volvulus Huntingtin homolog 0.0114 0.021 0.0744
Schistosoma mansoni hypothetical protein 0.0167 0.032 0.1241
Schistosoma mansoni pyruvate kinase 0.0017 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0171 0.0328 0.1273
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0116 0.0327
Brugia malayi hypothetical protein 0.0136 0.0257 0.1001
Echinococcus granulosus expressed conserved protein 0.0454 0.0925 0.265
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0208 0.1261
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0027 0.0103
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.021 0.0411 0.2467
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0054 0.021
Echinococcus granulosus dna polymerase eta 0.002 0.0011 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Toxoplasma gondii hypothetical protein 0.1232 0.2563 1
Onchocerca volvulus 0.0029 0.0031 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0116 0.0453
Leishmania major chitinase 0.0926 0.192 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.021 0.0411 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0062 0.0099 0.1669
Brugia malayi intermediate filament protein 0.0027 0.0027 0.0103
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0208 0.0803
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Brugia malayi PHD-finger family protein 0.0029 0.0031 0.0121
Toxoplasma gondii patched family protein 0.0029 0.0031 0.0112
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0062 0.0099 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0068 0.0619
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0195
Echinococcus granulosus replication factor c subunit 1 0.0038 0.005 0.0136
Giardia lamblia Serine peptidase, putative 0.0025 0.0021 0.0277
Leishmania major 4-coumarate:coa ligase-like protein 0.021 0.0411 0.2132
Toxoplasma gondii patched family protein 0.0029 0.0031 0.0112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0271 0.0772
Onchocerca volvulus Putative endochitinase 0.1038 0.2155 0.8394
Brugia malayi hypothetical protein 0.0114 0.021 0.082
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.0113 0.0208 0.0812
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0039 0.1398
Onchocerca volvulus 0.0033 0.0039 0.0069
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0039 0.0192
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Loa Loa (eye worm) hypothetical protein 0.1173 0.2439 0.9516
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0011 0.0338
Brugia malayi hypothetical protein 0.0025 0.0022 0.0085
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0039 0.0036
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0062 0.0099 0.0593
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Loa Loa (eye worm) hypothetical protein 0.0136 0.0257 0.1001
Echinococcus granulosus tumor protein p63 0.167 0.3485 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0054 0.1956
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0208 0.1261
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0037 0.0136
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0037 0.0145
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0039 0.0144
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0062 0.0099 0.0278
Echinococcus granulosus cpg binding protein 0.0032 0.0036 0.0098
Echinococcus multilocularis neuropeptide receptor A26 0.0901 0.1867 0.1865
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0054 0.0051
Brugia malayi ecdysone receptor 0.0033 0.0039 0.0151
Schistosoma mansoni Smad4 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0141 0.0266 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0208 0.0803
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0208 0.059
Plasmodium falciparum peptidase, putative 0.0033 0.0039 0.0144
Onchocerca volvulus Putative endochitinase 0.0926 0.192 0.7469
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0116 0.0114
Onchocerca volvulus 0.0058 0.0092 0.028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0099 0.0387
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0062 0.0099 0.0378
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0039 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0099 0.0387
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0037 0.0213
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.1232 0.2563 0.7352
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0208 0.1261
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0116 0.0453
Brugia malayi Ets-domain containing protein 0.0082 0.0142 0.0555
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0039 0.0037
Trypanosoma brucei oligopeptidase b 0.0033 0.0039 0.1398
Brugia malayi Pre-SET motif family protein 0.0058 0.0092 0.0359
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0038 0.005 0.0195
Brugia malayi Serine carboxypeptidase S28 family protein 0.0025 0.0021 0.0082
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0044 0.0359
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0077 0.0132 0.0129
Loa Loa (eye worm) inositol-1 0.0036 0.0044 0.0174
Brugia malayi Glycosyl hydrolases family 18 protein 0.0136 0.0257 0.1001
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0183
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0237 0.0469 0.2863
Onchocerca volvulus Protein patched homolog 0.0029 0.0031 0.004
Onchocerca volvulus 0.1232 0.2563 1
Onchocerca volvulus 0.0038 0.005 0.0114
Brugia malayi CHE-14 protein 0.0208 0.0406 0.1585
Mycobacterium ulcerans acyl-CoA synthetase 0.021 0.0411 0.2467
Schistosoma mansoni zinc finger protein 0.0033 0.0039 0.0141
Loa Loa (eye worm) patched family protein 0.0029 0.0031 0.0122
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0062 0.0099 0.0593
Trichomonas vaginalis antibiotic synthetase, putative 0.0062 0.0099 0.0952
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0037 0.0145
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0037 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Brugia malayi nuclear receptor NHR-88 0.0033 0.0039 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0116 0.0444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0039 0.0146
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Leishmania major hypothetical protein, conserved 0.0113 0.0208 0.1072
Schistosoma mansoni tar DNA-binding protein 0.0133 0.025 0.0965
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0145
Schistosoma mansoni lamin 0.0027 0.0027 0.0094
Echinococcus granulosus geminin 0.0171 0.0328 0.0936
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0116 0.0453
Onchocerca volvulus 0.0029 0.0031 0.004
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0039 0.0577
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0039 0.0151
Loa Loa (eye worm) cuticular endochitinase 0.0926 0.192 0.7489
Toxoplasma gondii aldehyde dehydrogenase 0.0237 0.0469 0.1822
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0082
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0015
Plasmodium vivax acyl-CoA synthetase, putative 0.0157 0.03 0.116
Schistosoma mansoni hypothetical protein 0.0029 0.0031 0.0112
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0039 0.0146
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.0299 0.0296
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0054 0.1956
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0092 0.035
Brugia malayi Inositol-1 0.0036 0.0044 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0039 0.0104
Schistosoma mansoni jumonji domain containing protein 0.0076 0.013 0.0498
Echinococcus multilocularis tar DNA binding protein 0.0133 0.025 0.0247
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0037 0.0016
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0142 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0116 0.0453
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0021 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0068 0.0619
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0039 0.0153
Mycobacterium tuberculosis Possible chitinase 0.079 0.1632 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0148 0.0282 0.1712
Plasmodium falciparum replication factor C subunit 1, putative 0.0038 0.005 0.0186
Brugia malayi Smad1 0.0016 0.0004 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.021 0.0411 0.2132
Schistosoma mansoni cellular tumor antigen P53 0.0245 0.0484 0.1881
Mycobacterium ulcerans aldehyde dehydrogenase 0.0237 0.0469 0.2824
Brugia malayi Myosin head containing protein 0.0029 0.0031 0.0122
Brugia malayi Ets-domain containing protein 0.0082 0.0142 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0021 0.0105
Onchocerca volvulus 0.0112 0.0205 0.0722
Trichomonas vaginalis chitinase, putative 0.0136 0.0257 0.2661
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0039 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0208 0.7814
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0116 0.0114
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0271 0.1059
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0021 0.0051
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.0112 0.0205 0.0798
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0116 0.0453
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.1232 0.2563 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.005 0.0419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0038 0.005 0.0419
Trichomonas vaginalis set domain proteins, putative 0.0458 0.0933 1
Brugia malayi Fli-1 protein 0.0249 0.0494 0.1928
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0116 0.0453
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0054 0.0462
Brugia malayi prolyl oligopeptidase family protein 0.0418 0.085 0.3317
Loa Loa (eye worm) beta-lactamase 0.0113 0.0208 0.0812
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0039 0.0153
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.082
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0039 0.007
Schistosoma mansoni alpha-glucosidase 0.0135 0.0253 0.0977
Loa Loa (eye worm) hypothetical protein 0.021 0.0411 0.1605
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0169 0.6344
Schistosoma mansoni thyroid hormone receptor 0.007 0.0116 0.0444
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0055 0.0053
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0039 0.0036
Brugia malayi nuclear hormone receptor 0.0033 0.0039 0.0151
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0039 0.0144
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0038 0.005 0.0238
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0037 0.1321
Brugia malayi Pre-SET motif family protein 0.0402 0.0817 0.3186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0092 0.035
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0031 0.0121
Trypanosoma brucei polo-like protein kinase 0.0095 0.0169 0.6344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0082
Brugia malayi latrophilin 2 splice variant baaae 0.0167 0.032 0.1249
Loa Loa (eye worm) chitinase I 0.0926 0.192 0.7489
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0039 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0271 0.0772
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Echinococcus granulosus neuropeptide receptor A26 0.0901 0.1867 0.5353
Schistosoma mansoni chitinase 0.0136 0.0257 0.0993
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0062 0.0099 0.0593
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0011 0.0055
Loa Loa (eye worm) hypothetical protein 0.1232 0.2563 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0037 0.0064
Brugia malayi hypothetical protein 0.0108 0.0196 0.0764
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0402 0.0817 0.3186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0271 0.1059
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0081 0.0483
Echinococcus multilocularis protein dispatched 1 0.0237 0.0468 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.0611 1
Onchocerca volvulus 0.0112 0.0205 0.0722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0271 0.105
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0021 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0141 0.0266 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0022 0.0737
Echinococcus multilocularis nibrin 0.0038 0.005 0.0048
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0119
Giardia lamblia Pyruvate kinase 0.0032 0.0037 0.0544
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0172 0.0485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0244 0.0482 0.1882
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0042 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.0406 0.4283
Entamoeba histolytica acyl-CoA synthetase, putative 0.021 0.0411 0.2096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0208 0.1261
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0195
Entamoeba histolytica acyl-coA synthetase, putative 0.021 0.0411 0.2096
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0039 0.1398
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0054 0.0263
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0062 0.0099 0.0387
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0153
Brugia malayi Glycosyl hydrolases family 31 protein 0.0156 0.0299 0.1165
Trichomonas vaginalis replication factor C large subunit, putative 0.0038 0.005 0.0419
Onchocerca volvulus 0.0112 0.0205 0.0722
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0044 0.0359
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0044 0.0042
Brugia malayi beta-lactamase family protein 0.0113 0.0208 0.0812
Schistosoma mansoni thyroid hormone receptor 0.007 0.0116 0.0444
Leishmania major acetyl-CoA synthetase, putative 0.0062 0.0099 0.0504
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0039 0.0144
Onchocerca volvulus 0.0029 0.0031 0.004
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.0475 0.1851
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0116 0.0453
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0116 0.0327
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0039 0.0151
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Plasmodium falciparum lipid/sterol:H+ symporter 0.0029 0.0031 0.0112
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0039 0.1398
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0062 0.0099 0.0387
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0113 0.0208 0.0812
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0195
Brugia malayi Patched related family protein 4 0.0029 0.0031 0.0122
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0031 0.0112
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0156 0.0299 0.1165
Echinococcus multilocularis expressed conserved protein 0.0454 0.0925 0.0923
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0113 0.0208 0.0812
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0092 0.035
Plasmodium falciparum pyruvate kinase 0.0032 0.0037 0.0136
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0092 0.0257
Trichomonas vaginalis esterase, putative 0.0113 0.0208 0.2133
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0022 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Schistosoma mansoni microtubule-associated protein tau 0.067 0.138 0.5378
Trypanosoma brucei unspecified product 0.002 0.0011 0.0338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Schistosoma mansoni hypothetical protein 0.0077 0.0132 0.0505
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0157 0.03 0.1778
Mycobacterium ulcerans acyl-CoA synthetase 0.021 0.0411 0.2467
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0025 0.0021 0.0053
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0039 0.1398
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0031 0.0029
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0047 0.0128
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0011 0.0044
Loa Loa (eye worm) hypothetical protein 0.0113 0.0208 0.0812
Echinococcus multilocularis pyruvate kinase 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0132 0.0514
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Schistosoma mansoni kinase 0.0048 0.0071 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0042 0.0338
Loa Loa (eye worm) hypothetical protein 0.0113 0.0208 0.0812
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0208 0.2133
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0039 0.0151
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0027 0.0103
Brugia malayi hypothetical protein 0.0029 0.0031 0.0122
Onchocerca volvulus 0.0245 0.0484 0.1821
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0054 0.0268
Entamoeba histolytica acyl-CoA synthetase, putative 0.021 0.0411 0.2096
Echinococcus granulosus FTZ F1 alpha 0.0466 0.0951 0.2724
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0183
Loa Loa (eye worm) prolyl oligopeptidase 0.0418 0.085 0.3317
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.005 0.0419
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0097 0.0378
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0038 0.005 0.0419
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0077 0.0132 0.0371
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0054 0.1956
Brugia malayi Bromodomain containing protein 0.0029 0.0031 0.0121
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.021 0.0411 0.2467
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0116 0.0327
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0039 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0338
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0116 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0208 0.2133
Brugia malayi hypothetical protein 0.0037 0.0047 0.0183
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0038 0.005 0.0356
Schistosoma mansoni tar DNA-binding protein 0.0133 0.025 0.0965
Brugia malayi Endochitinase 0.1038 0.2155 0.8407
Echinococcus multilocularis lamin dm0 0.0027 0.0027 0.0024
Schistosoma mansoni patched 1 0.0208 0.0406 0.1577
Schistosoma mansoni topbp1 0.0038 0.005 0.0186
Brugia malayi Calcitonin receptor-like protein seb-1 0.0244 0.0482 0.1882
Loa Loa (eye worm) DR-78 0.0033 0.0039 0.0151
Brugia malayi steroid hormone receptor 0.007 0.0116 0.0453
Echinococcus granulosus tar DNA binding protein 0.0133 0.025 0.071
Loa Loa (eye worm) hypothetical protein 0.0245 0.0484 0.1889
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0116 0.0114
Schistosoma mansoni gabp alpha 0.0082 0.0142 0.0546
Leishmania major DNA polymerase kappa, putative 0.002 0.0011 0.0046
Echinococcus multilocularis peregrin 0.0029 0.0031 0.0029
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0136 0.0257 0.073
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.0039 0.0226
Onchocerca volvulus Alhambra homolog 0.0029 0.0031 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.021 0.0411 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0157 0.03 0.1823
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0039 0.0104
Loa Loa (eye worm) patched family protein 0.0029 0.0031 0.0122
Brugia malayi protein C24B5.3 0.0029 0.0031 0.0122
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0044 0.1597
Echinococcus granulosus nibrin 0.0038 0.005 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0037 0.0145
Onchocerca volvulus 0.0062 0.0099 0.0307
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0039 0.0106
Giardia lamblia Replication factor C, subunit 1 0.0038 0.005 0.0754
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0271 0.0269
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0011 0.0009
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0141 0.0266 0.1028
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0141 0.0266 0.0263
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0195
Schistosoma mansoni hypothetical protein 0.0171 0.0328 0.1273
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0042 0.0338
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0031 0.0112
Plasmodium vivax acetyl-CoA synthetase, putative 0.0062 0.0099 0.0378
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0039 0.0172
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0039 0.0144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0037 0.021
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Entamoeba histolytica hypothetical protein 0.0115 0.0212 0.1052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0116 0.0374
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0017 0.0028
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0001
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0112 0.0205 0.0798
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0208 0.1261
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.005 0.0419
Echinococcus multilocularis tumor protein p63 0.167 0.3485 0.3484
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0044 0.0219
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0283 0.1675
Schistosoma mansoni hypothetical protein 0.02 0.039 0.1515
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0092 0.035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0153
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.021 0.0411 0.2467
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0116 0.0114
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0042 0.0338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0116 0.0114
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0044 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0116 0.0453
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0112 0.0205 0.0798
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0418 0.085 0.3262
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0039 0.0153
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0038 0.005 0.0419
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0037 0.0064
Brugia malayi Patched related family protein 10 0.0029 0.0031 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0042 0.0338
Schistosoma mansoni ap endonuclease 0.004 0.0054 0.0201
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0077 0.0132 0.0371
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0244 0.0482 0.1882
Brugia malayi protein C24B5.3 0.0029 0.0031 0.0122
Onchocerca volvulus 0.0112 0.0205 0.0722
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0039 0.1398
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.001 0.0029
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0062 0.0099 0.0593
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0047 0.0183
Schistosoma mansoni nuclear receptor 0.0033 0.0039 0.0141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0116 0.0114
Plasmodium vivax hypothetical protein, conserved 0.1232 0.2563 1
Mycobacterium tuberculosis Probable peptidase 0.0033 0.0039 0.0226
Echinococcus granulosus sterol regulatory element binding protein 0.0208 0.0406 0.1159
Loa Loa (eye worm) hypothetical protein 0.0167 0.032 0.1249
Echinococcus granulosus pyruvate kinase 0.0017 0.0004 0.0005
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0141 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0153
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.0475 0.1851
Plasmodium falciparum acyl-CoA synthetase 0.0157 0.03 0.116
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0075 0.0293
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0025 0.0021 0.0019
Echinococcus multilocularis pyruvate kinase 0.0032 0.0037 0.0035
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0039 0.0104
Echinococcus granulosus Niemann Pick C1 protein 0.0691 0.1424 0.4081
Onchocerca volvulus Putative endochitinase 0.0926 0.192 0.7469
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0082
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0237 0.0469 0.0467
Entamoeba histolytica hypothetical protein 0.0115 0.0212 0.1052
Echinococcus multilocularis pyruvate kinase 0.0025 0.0023 0.002
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0062 0.0099 0.0593
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0208 0.2133
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0054 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0042 0.0209
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0042 0.1521
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0271 0.0269
Onchocerca volvulus 0.0062 0.0099 0.0307
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0004 0.0007
Chlamydia trachomatis DNA ligase 0.0038 0.005 0.0486
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0039 0.0104
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0169 0.0828
Loa Loa (eye worm) hypothetical protein 0.0484 0.0987 0.3852
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0039 0.0036
Schistosoma mansoni DNA ligase IV 0.0038 0.005 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0021 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.005 0.0419
Schistosoma mansoni lamin 0.0027 0.0027 0.0094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0183
Echinococcus granulosus pyruvate kinase 0.0032 0.0037 0.01
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0116 0.0453
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0039 0.0153
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.1232 0.2563 0.2561
Mycobacterium ulcerans aldehyde dehydrogenase 0.0237 0.0469 0.2824
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0062 0.0099 0.3675
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.021 0.0411 0.2508
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0042 0.0338
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0212 0.021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0054 0.0316
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0142 0.0555
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0054 0.0201
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0903 0.1871 0.7299
Brugia malayi MH2 domain containing protein 0.024 0.0475 0.1851
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.0116 0.0444
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0039 0.1398
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0062 0.0099 0.0387
Plasmodium falciparum chitinase 0.0136 0.0257 0.0993
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0062 0.0099 0.0542
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0077 0.0132 0.0514
Echinococcus granulosus lamin 0.0027 0.0027 0.0069
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.025 0.0974
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Onchocerca volvulus 0.0029 0.0031 0.004
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Echinococcus multilocularis microtubule associated protein 2 0.067 0.138 0.1377
Echinococcus granulosus pyruvate kinase 0.0032 0.0037 0.01
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Echinococcus multilocularis Niemann Pick C1 protein 0.0691 0.1424 0.1422
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0039 0.0104
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0038 0.005 0.0419
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0456 0.093 0.0928
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0338
Loa Loa (eye worm) fli-1 protein 0.0249 0.0494 0.1928
Brugia malayi follicle stimulating hormone receptor 0.0903 0.1871 0.7299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0237 0.0469 0.134
Onchocerca volvulus 0.007 0.0116 0.0374
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0116 0.0444
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0062 0.0099 0.0504
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0062 0.0099 0.0542
Brugia malayi jmjC domain containing protein 0.0037 0.0048 0.0186
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0121
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0021 0.0707
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0047 0.0183
Loa Loa (eye worm) hypothetical protein 0.0157 0.03 0.1169
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0062 0.0099 0.0542
Echinococcus multilocularis pyruvate kinase 0.0032 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0183
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0038 0.005 0.0202
Schistosoma mansoni cpg binding protein 0.0032 0.0036 0.0133
Toxoplasma gondii patched family protein 0.0029 0.0031 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.0076
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0042 0.1521
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0042 0.0338
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0048 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.021 0.0411 0.1605
Leishmania major acetyl-CoA synthetase, putative 0.0062 0.0099 0.0504
Schistosoma mansoni hypothetical protein 0.1232 0.2563 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0039 0.0141
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0048 0.013
Loa Loa (eye worm) hypothetical protein 0.0112 0.0205 0.0798
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0038 0.005 0.1806
Onchocerca volvulus Putative endochitinase 0.0136 0.0257 0.0927
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0183
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0062 0.0099 0.3675
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0151
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0062 0.0099 0.0542
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Echinococcus multilocularis lamin 0.0027 0.0027 0.0024
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0042 0.0338
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0004 0.0007
Schistosoma mansoni ap endonuclease 0.004 0.0054 0.0201
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0005 0.0079
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0148 0.0282 0.1712
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0338
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0338
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0116 0.0374
Echinococcus multilocularis sterol regulatory element binding protein 0.0208 0.0406 0.0404
Loa Loa (eye worm) hypothetical protein 0.0058 0.0092 0.0359
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0033 0.0128
Brugia malayi beta-lactamase family protein 0.0113 0.0208 0.0812
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0042 0.0338
Onchocerca volvulus 0.0027 0.0027 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0116 0.0453
Leishmania major pyruvate kinase 0.0032 0.0037 0.0181
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0039 0.1398
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0044 0.1597
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0021 0.0082
Brugia malayi hypothetical protein 0.0029 0.0031 0.0122
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0169 0.0583
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0031 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Schistosoma mansoni alpha-glucosidase 0.0135 0.0253 0.0977
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0011 0.0055
Brugia malayi hypothetical protein 0.0038 0.005 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0271 0.105
Echinococcus multilocularis pyruvate kinase 0.0017 0.0004 0.0002
Brugia malayi hypothetical protein 0.0037 0.0047 0.0183
Toxoplasma gondii patched family protein 0.0029 0.0031 0.0112
Mycobacterium leprae Probable lipase LipE 0.0113 0.0208 0.4576
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0025 0.0021 0.0073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0054 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0157 0.03 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0037 0.1321
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0338
Brugia malayi nuclear receptor RXR 0.0033 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.079 0.1632 0.6369
Brugia malayi nuclear receptor RXR 0.0037 0.0047 0.0183
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0054 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0116 0.0453
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0116 0.0114
Brugia malayi AMP-binding enzyme family protein 0.021 0.0411 0.1605
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0042 0.0163
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0039 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.0114 0.021 0.082
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0025 0.0021 0.0707
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0169 0.0871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0116 0.0453
Giardia lamblia Thymus-specific serine protease precursor 0.0025 0.0021 0.0277
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0062 0.0099 0.0542
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0044 0.0204
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0055 0.0152
Onchocerca volvulus 0.0239 0.0473 0.1778
Schistosoma mansoni hypothetical protein 0.0077 0.0132 0.0505
Loa Loa (eye worm) oxidoreductase 0.0062 0.0099 0.0387
Echinococcus granulosus pyruvate kinase 0.0017 0.0004 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0011 0.0044
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0015
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Toxoplasma gondii hypothetical protein 0.0029 0.0031 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0338
Onchocerca volvulus 0.021 0.0411 0.1535
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0484 0.0987 0.5114
Brugia malayi hypothetical protein 0.0033 0.0039 0.0151
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0021 0.0105
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0491 0.1003 0.3907
Brugia malayi Patched family protein 0.0029 0.0031 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0169 0.1714
Schistosoma mansoni topbp1 0.0038 0.005 0.0186
Brugia malayi tailless protein 0.0033 0.0039 0.0151
Schistosoma mansoni chromosome transmission fidelity factor 0.0038 0.005 0.0186
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.0076
Onchocerca volvulus 0.0029 0.0031 0.004
Trypanosoma brucei glucosidase, putative 0.0035 0.0042 0.1521
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0208 0.4576
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0099 0.0387
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0037 0.1321
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0094 0.0358
Onchocerca volvulus 0.1232 0.2563 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0031 0.0082
Schistosoma mansoni hypothetical protein 0.0077 0.0132 0.0505
Schistosoma mansoni tar DNA-binding protein 0.0133 0.025 0.0965
Brugia malayi nuclear hormone receptor 0.007 0.0116 0.0453
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0196 0.0764
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0116 0.0444
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0092 0.009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0099
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0062 0.0099 0.1669
Echinococcus granulosus lysosomal alpha glucosidase 0.0156 0.0299 0.085
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0038 0.005 0.1806
Onchocerca volvulus 0.0112 0.0205 0.0722
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0116 0.0453
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.025 0.0974
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0169 0.0479
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0044 0.0359
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0062 0.0099 0.0542
Onchocerca volvulus 0.0033 0.0039 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0022 0.0076
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0062 0.0099 0.0593
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0116 0.0327
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0112 0.0205 0.0798
Schistosoma mansoni tar DNA-binding protein 0.0133 0.025 0.0965
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0037 0.0136
Echinococcus granulosus Smad4 0.0016 0.0004 0.0004
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0453
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0039 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Onchocerca volvulus 0.0029 0.0031 0.004
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0418 0.085 0.2434
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0039 0.1398
Echinococcus granulosus Niemann Pick C1 protein 0.0484 0.0987 0.2827
Brugia malayi hypothetical protein 0.0016 0.0003 0.0013
Toxoplasma gondii ABC1 family protein 0.0113 0.0208 0.0803
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0208 0.0206
Onchocerca volvulus 0.0113 0.0208 0.0736
Schistosoma mansoni aldehyde dehydrogenase 0.0237 0.0469 0.1822
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.0611 0.3143
Plasmodium vivax SET domain protein, putative 0.0058 0.0092 0.035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0047 0.0174
Brugia malayi AMP-binding enzyme family protein 0.021 0.0411 0.1605
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0037 0.016
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0208 0.1214
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0062 0.0099 0.046
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0017 0.0065
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Entamoeba histolytica hypothetical protein, conserved 0.0136 0.0257 0.1286
Onchocerca volvulus Putative endochitinase 0.1038 0.2155 0.8394
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0611 0.6505
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0724 0.1494 0.9151
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0092 0.009
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0011 0.0338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0039 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.021 0.0411 0.2132
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0169 0.0652
Leishmania major oligopeptidase b 0.0033 0.0039 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0116 0.0453
Echinococcus granulosus Protein patched homolog 1 0.0208 0.0406 0.1159
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0062 0.0099 0.0542
Echinococcus multilocularis survival motor neuron protein 1 0.1173 0.2439 0.2437
Schistosoma mansoni hypothetical protein 0.02 0.039 0.1515
Schistosoma mansoni nuclear hormone receptor 0.007 0.0116 0.0444
Mycobacterium ulcerans chitinase/cellulase 0.079 0.1632 1
Schistosoma mansoni pyruvate kinase 0.0032 0.0037 0.0136
Schistosoma mansoni hypothetical protein 0.0239 0.0473 0.1838
Mycobacterium ulcerans hypothetical protein 0.021 0.0411 0.2467
Loa Loa (eye worm) RNA binding protein 0.0133 0.025 0.0974
Brugia malayi topoisomerase 0.0038 0.005 0.0195
Schistosoma mansoni hypothetical protein 0.0115 0.0212 0.0819
Brugia malayi hypothetical protein 0.0033 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Echinococcus granulosus survival motor neuron protein 1 0.1173 0.2439 0.6996
Onchocerca volvulus Huntingtin homolog 0.0114 0.021 0.0744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0271 0.105
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0062 0.0099 0.1669
Echinococcus granulosus lamin dm0 0.0027 0.0027 0.0069
Mycobacterium tuberculosis Conserved protein 0.0113 0.0208 0.1261
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0037 0.0281
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0116 0.0444
Plasmodium falciparum phd finger protein, putative 0.0029 0.0031 0.0112
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Entamoeba histolytica hypothetical protein 0.0115 0.0212 0.1052
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0039 0.0069
Leishmania major hypothetical protein, conserved 0.0025 0.0022 0.0101
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0011 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0099 0.0542
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0208 0.7814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0122
Echinococcus granulosus peregrin 0.0029 0.0031 0.0082
Loa Loa (eye worm) hypothetical protein 0.0157 0.03 0.1169
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0021 0.0051
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0062 0.0099 0.0097
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0042 0.004
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.0611 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 52 % Reduction of glucose levels in TallyHo mouse at 10 mg/kg administered 30 mins before oral glucose challenge ChEMBL. 17331715
Activity (functional) = 77 % Reduction of glucose levels in TallyHo mouse at 50 mg/kg administered 30 mins before oral glucose challenge ChEMBL. 17331715
IC50 (binding) = -6.15 Inhibition of DPP4 ChEMBL. 17462890
IC50 (binding) = -4.31 Inhibition of DPP9 ChEMBL. 17462890
IC50 (binding) = -4.05 Inhibition of DPP8 ChEMBL. 17462890
IC50 (binding) = 70 nM Inhibition of DPP4 ChEMBL. 17331715
IC50 (binding) = 18190 nM Inhibition of DPP2 ChEMBL. 17331715
IC50 (binding) = 48660 nM Inhibition of DPP9 ChEMBL. 17331715
IC50 (binding) = 89120 nM Inhibition of DPP8 ChEMBL. 17331715
IC50 (binding) > 100000 nM Inhibition of APN ChEMBL. 17331715
IC50 (binding) > 1000000 nM Inhibition of POP ChEMBL. 17331715
IC50 (binding) > 1000000 nM Inhibition of trypsin ChEMBL. 17331715
Inhibition (binding) = 46 % Inhibition of pig kidney DPP4-mediated GLP1 degradation at 1 uM after 24 hrs ChEMBL. 17331715
Inhibition (binding) = 85 % Inhibition of pig kidney DPP4-mediated GLP1 degradation at 10 uM after 24 hrs ChEMBL. 17331715
Inhibition (functional) = 90 % Inhibition of DPP4 in C57BL/6 mouse plasma at 50 mg/kg, po after 1 hr ChEMBL. 17331715
Ki (binding) = 56.2 nM Inhibition of pig kidney DPP4 ChEMBL. 17331715

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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