Detailed information for compound 944595

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.684 | Formula: C30H46O4
  • H donors: 0 H acceptors: 2 LogP: 6.88 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1C[C@]2(OC1=O)C[C@H]([C@]1(O2)CC[C@@]2([C@]1(C)CC[C@@H]1[C@@H]2CC[C@@H]2[C@]1(C)CCC(=O)C2(C)C)C)C
  • InChi: 1S/C30H46O4/c1-18-16-29(33-24(18)32)17-19(2)30(34-29)15-14-27(6)21-8-9-22-25(3,4)23(31)11-12-26(22,5)20(21)10-13-28(27,30)7/h18-22H,8-17H2,1-7H3/t18-,19-,20-,21+,22+,26-,27+,28+,29-,30-/m1/s1
  • InChiKey: MRFPZBMYKNLHSO-XUCRJPSZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0073 0.0119
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.0501 0.0813
Leishmania major hypothetical protein, conserved 0.0072 0.0146 0.023
Onchocerca volvulus 0.0018 0.0015 0.0043
Onchocerca volvulus 0.0021 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0107
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0143 0.0317 0.0313
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0898 0.2138 0.3463
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0143 0.0317 0.0509
Trypanosoma brucei heat shock protein 90, putative 0.0143 0.0317 0.0509
Brugia malayi kinase, mitochondrial precursor 0.2569 0.6165 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0112 0.0243 0.0395
Trypanosoma brucei ISWI complex protein 0.0015 0.0009 0.0008
Mycobacterium ulcerans lipase LipD 0.0072 0.0146 0.0142
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0143 0.0317 0.0337
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0293 0.0679 0.1101
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0003 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0143 0.0317 0.4673
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0104 0.0168
Echinococcus multilocularis Niemann Pick C1 protein 0.0291 0.0675 0.1095
Echinococcus granulosus heat shock protein 0.0143 0.0317 0.0515
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.0099 0.1462
Loa Loa (eye worm) hypothetical protein 0.007 0.0142 0.023
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0143 0.0317 0.0313
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0088 0.0142
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0117 0.0113
Trypanosoma cruzi ISWI complex protein 0.0015 0.0009 0.0008
Brugia malayi Myosin head containing protein 0.0018 0.0015 0.0025
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0072 0.0146 0.0236
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0016 0.0013
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0293 0.0679 0.1101
Schistosoma mansoni rab6-interacting 0.0019 0.002 0.0032
Echinococcus granulosus chromobox protein 1 0.0069 0.0139 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0023 0.0037
Schistosoma mansoni bromodomain containing protein 0.0068 0.0136 0.0221
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0143 0.0317 0.0313
Brugia malayi beta-lactamase family protein 0.0072 0.0146 0.0236
Leishmania major mitochondrial DNA topoisomerase II 0.0143 0.0317 0.0509
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0023 0.0037
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0023 0.002
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0143 0.0317 0.0884
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0013 0.0022
Mycobacterium leprae Probable two-component sensor kinase 0.0143 0.0317 0.449
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0087 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2569 0.6165 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0146 0.0236
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0023 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0295
Echinococcus granulosus zinc finger protein 0.0025 0.0032 0.0052
Echinococcus multilocularis chromobox protein 1 0.0069 0.0139 0.0225
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0146 0.0153
Plasmodium falciparum glutathione reductase 0.0037 0.0063 0.0922
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0032
Mycobacterium tuberculosis Conserved protein 0.0072 0.0146 0.0153
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0023 0.003
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0088 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.02 0.0211
Trypanosoma brucei heat shock protein 90, putative 0.0143 0.0317 0.0509
Onchocerca volvulus Protein patched homolog 0.0018 0.0015 0.0043
Mycobacterium leprae Probable lipase LipE 0.0072 0.0146 0.1877
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0125 0.0274 0.0445
Onchocerca volvulus 0.0048 0.0088 0.0245
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0312 0.0725 0.1176
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0059 0.1758
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0143 0.0317 1
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Schistosoma mansoni survival motor neuron protein 0.0048 0.0087 0.0142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0146 0.0236
Loa Loa (eye worm) hypothetical protein 0.0293 0.0679 0.1101
Leishmania major DNA topoisomerase ii 0.0143 0.0317 0.0509
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0032
Plasmodium falciparum carbonic anhydrase 0.0219 0.0501 0.7381
Loa Loa (eye worm) hypothetical protein 0.0072 0.0146 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0143 0.0317 0.0337
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0312 0.0725 0.1176
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.2569 0.6165 1
Loa Loa (eye worm) hypothetical protein 0.1501 0.3591 0.5825
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0312 0.0725 0.117
Onchocerca volvulus 0.0018 0.0015 0.0042
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0142 0.2104
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0035
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0146 0.1877
Toxoplasma gondii thioredoxin reductase 0.0037 0.0063 0.0252
Brugia malayi hypothetical protein 0.0293 0.0679 0.1101
Schistosoma mansoni endoplasmin 0.0143 0.0317 0.0515
Schistosoma mansoni lipoxygenase 0.0054 0.0104 0.0169
Echinococcus multilocularis neuropeptide receptor A26 0.1399 0.3345 0.5426
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0545 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0086 0.0139
Trypanosoma cruzi heat shock protein 90, putative 0.0143 0.0317 0.0509
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0117 0.0113
Loa Loa (eye worm) TOPoisomerase family member 0.0143 0.0317 0.0515
Onchocerca volvulus 0.0019 0.0018 0.0051
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.0501 0.0813
Toxoplasma gondii hypothetical protein 0.0018 0.0015 0.0062
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0219 0.0501 0.0813
Echinococcus multilocularis carbonic anhydrase 0.0219 0.0501 0.0813
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trichomonas vaginalis DNA topoisomerase II, putative 0.0143 0.0317 0.5822
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0023 0.002
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0023 0.0414
Mycobacterium ulcerans beta-lactamase 0.0072 0.0146 0.0142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0009 0.0158
Onchocerca volvulus 0.1501 0.3591 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0143 0.0317 0.0337
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.1501 0.3591 0.5825
Brugia malayi hypothetical protein 0.0106 0.0229 0.0372
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0023 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0146 0.023
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Onchocerca volvulus 0.0048 0.0087 0.0243
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0312 0.0725 0.1176
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0143 0.0317 0.0313
Schistosoma mansoni amine oxidase 0.0293 0.0679 0.1101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0044 0.0071
Mycobacterium ulcerans oxidoreductase 0.0293 0.0679 0.0675
Onchocerca volvulus 0.0019 0.002 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0216 0.0351
Schistosoma mansoni cpg binding protein 0.0033 0.0052 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Plasmodium vivax DNA topoisomerase II, putative 0.0143 0.0317 0.4673
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Plasmodium vivax SET domain protein, putative 0.003 0.0046 0.0682
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.0089
Toxoplasma gondii hypothetical protein 0.0219 0.0501 0.2019
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0023 0.002
Loa Loa (eye worm) endoplasmin 0.0143 0.0317 0.0515
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0142 0.0224
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0000000030118 0.0000000048854
Leishmania major UDP-galactopyranose mutase 0.0293 0.0679 0.1096
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) carbonic anhydrase 3 0.0312 0.0725 0.1176
Plasmodium vivax hypothetical protein, conserved 0.0293 0.0679 1
Schistosoma mansoni hypothetical protein 0.0048 0.0087 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0274 0.503
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0004 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.0983 0.1595
Trypanosoma brucei Heat shock protein 83, putative 0.0143 0.0317 0.0509
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.003 0.0049
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0104 0.0168
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0004 0.0058
Plasmodium falciparum glutathione reductase 0.0013 0.0004 0.0058
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0059 0.0875
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Schistosoma mansoni chromobox protein 0.0069 0.0139 0.0225
Schistosoma mansoni hypothetical protein 0.029 0.0672 0.1089
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0146 0.2674
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0023 0.0332
Trichomonas vaginalis heat shock protein, putative 0.0143 0.0317 0.5822
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.002 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0295
Brugia malayi Endoplasmin precursor 0.0143 0.0317 0.0515
Loa Loa (eye worm) hypothetical protein 0.0293 0.0679 0.1101
Onchocerca volvulus 0.0072 0.0146 0.0406
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0013 0.0022
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0143 0.0317 0.0515
Loa Loa (eye worm) hypothetical protein 0.0233 0.0534 0.0867
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0462 0.1086 0.1762
Echinococcus granulosus cpg binding protein 0.0033 0.0052 0.0085
Brugia malayi AMP-binding enzyme family protein 0.007 0.0142 0.023
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0088 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi Protein kinase domain containing protein 0.0019 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0291 0.0675 0.1095
Echinococcus granulosus carbonic anhydrase 0.0219 0.0501 0.0813
Chlamydia trachomatis DNA gyrase subunit B 0.0143 0.0317 0.4642
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0229 0.0372
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0143 0.0317 0.0509
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0143 0.0317 0.0337
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0329 0.0534
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0146 0.023
Loa Loa (eye worm) DOMON domain-containing protein 0.0018 0.0015 0.0024
Echinococcus granulosus carbonic anhydrase 0.0219 0.0501 0.0813
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0025
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0088 0.0142
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0088 0.0142
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0084 0.1537
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0023 0.002
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0004 0.0073
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0023 0.0414
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0004 0.0016
Echinococcus multilocularis protein dispatched 1 0.0143 0.0317 0.0514
Brugia malayi hypothetical protein 0.0019 0.002 0.0032
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0023 0.0037
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0426 0.0691
Schistosoma mansoni hypothetical protein 0.012 0.0263 0.0427
Onchocerca volvulus 0.0029 0.0044 0.0122
Loa Loa (eye worm) glutathione reductase 0.0037 0.0063 0.0102
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0293 0.0679 0.0675
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0023 0.003
Loa Loa (eye worm) heat shock protein 90 0.0143 0.0317 0.0515
Onchocerca volvulus 0.0011 0.0000000030118 0.0000000083876
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0329 0.0534
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0142 0.182
Trypanosoma brucei developmentally regulated phosphoprotein 0.2569 0.6165 1
Schistosoma mansoni loxhd1 0.0019 0.002 0.0032
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.2569 0.6165 1
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.003
Schistosoma mansoni hypothetical protein 0.0047 0.0086 0.0139
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0219 0.0501 0.0813
Loa Loa (eye worm) inositol-1 0.0036 0.0059 0.0096
Onchocerca volvulus 0.0018 0.0015 0.0043
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.0501 0.0813
Loa Loa (eye worm) hypothetical protein 0.0219 0.0501 0.0813
Echinococcus multilocularis heat shock protein 0.0143 0.0317 0.0515
Schistosoma mansoni cpg binding protein 0.0029 0.0044 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0293 0.0679 0.1101
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0143 0.0317 0.0515
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0293 0.0679 1
Schistosoma mansoni hypothetical protein 0.0419 0.0983 0.1595
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.02 0.0211
Entamoeba histolytica heat shock protein 90, putative 0.0143 0.0317 0.4702
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0024
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0023 0.0091
Brugia malayi mbt repeat family protein 0.0048 0.0088 0.0142
Brugia malayi heat shock protein 90 0.0143 0.0317 0.0515
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0023 0.002
Trypanosoma brucei trypanothione reductase 0.0037 0.0063 0.0095
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.005 0.0419
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0104 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0146 0.0236
Schistosoma mansoni hypothetical protein 0.012 0.0263 0.0427
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0146 0.0153
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0243 0.0395
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.0089
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Loa Loa (eye worm) hypothetical protein 0.007 0.0142 0.023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0146 0.0153
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0293 0.0679 1
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0069 0.1028
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0069 0.2088
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0143 0.0317 0.0509
Brugia malayi Muscleblind-like protein 0.0147 0.0328 0.0532
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0146 0.2674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0023 0.002
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0009 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0146 0.0153
Brugia malayi Pre-SET motif family protein 0.0209 0.0476 0.0772
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0143 0.0317 0.0337
Loa Loa (eye worm) hypothetical protein 0.0044 0.0078 0.0127
Echinococcus granulosus lysine specific histone demethylase 1A 0.0293 0.0679 0.1101
Toxoplasma gondii ABC1 family protein 0.0072 0.0146 0.0587
Plasmodium falciparum DNA gyrase subunit B 0.0143 0.0317 0.4673
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0104 0.0168
Brugia malayi mbt repeat family protein 0.0048 0.0088 0.0142
Mycobacterium ulcerans putative regultory protein 0.0143 0.0317 0.0313
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0023 0.0332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.2569 0.6165 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0023 0.002
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0023 0.003
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0064 0.0104
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0219 0.0501 0.0813
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0037
Brugia malayi hypothetical protein 0.0018 0.0015 0.0025
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0143 0.0317 0.0337
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Onchocerca volvulus 0.0021 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.007 0.0141 0.0228
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0143 0.0317 0.5822
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Mycobacterium tuberculosis Possible oxidoreductase 0.0293 0.0679 0.0727
Loa Loa (eye worm) hypothetical protein 0.0802 0.1907 0.3093
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0142 0.0138
Trichomonas vaginalis heat shock protein, putative 0.0143 0.0317 0.5822
Brugia malayi hypothetical protein 0.0606 0.1434 0.2325
Echinococcus granulosus carbonic anhydrase II 0.0312 0.0725 0.1176
Brugia malayi Heterochromatin protein 1 0.0069 0.0139 0.0225
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0084 0.0338
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0066 0.0183
Echinococcus granulosus heat shock protein 90 0.0143 0.0317 0.0515
Schistosoma mansoni heat shock protein 0.0143 0.0317 0.0515
Loa Loa (eye worm) hypothetical protein 0.0147 0.0328 0.0532
Loa Loa (eye worm) hypothetical protein 0.0143 0.0317 0.0515
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0023 0.002
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0208 0.0338
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0088 0.0142
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0143 0.0317 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0143 0.0317 1
Mycobacterium ulcerans hypothetical protein 0.007 0.0142 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0146 0.2674
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0143 0.0317 0.0313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0016 0.0295
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0009 0.0014
Echinococcus multilocularis heat shock protein 90 0.0143 0.0317 0.0515
Chlamydia trachomatis DNA gyrase subunit B 0.0143 0.0317 0.4642
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0009 0.0158
Echinococcus granulosus Protein patched homolog 1 0.0125 0.0274 0.0445
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0092 0.0095
Echinococcus multilocularis zinc finger protein 0.0025 0.0032 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0023 0.0037
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0117 0.019
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.02 0.271
Loa Loa (eye worm) hypothetical protein 0.1501 0.3591 0.5825
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0143 0.0317 0.0509
Plasmodium vivax patched family protein, putative 0.0018 0.0015 0.0227
Schistosoma mansoni rab6-interacting 0.0019 0.002 0.0032
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Brugia malayi Patched protein homolog 1 0.0018 0.0015 0.0025
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0293 0.0679 0.1101
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0142 0.2104
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0066 0.1207
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0086 0.0139
Echinococcus granulosus tumor protein p63 0.0667 0.1581 0.2564
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0293 0.0679 1
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0023 0.0091
Brugia malayi Patched related family protein 4 0.0018 0.0015 0.0025
Giardia lamblia Pms1-like protein 0.0143 0.0317 1
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.1501 0.3591 0.5825
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0059 0.0055
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0117 0.0122
Leishmania major hypothetical protein, conserved 0.0015 0.0009 0.0008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0321 0.052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0059 0.1083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0295
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0312 0.0725 0.1176
Schistosoma mansoni cpg binding protein 0.0033 0.0052 0.0085
Trichomonas vaginalis receptor histidine kinase, putative 0.0143 0.0317 0.5822
Entamoeba histolytica hypothetical protein 0.0106 0.0229 0.3399
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0898 0.2138 0.8612
Plasmodium vivax heat shock protein 86, putative 0.0143 0.0317 0.4673
Trypanosoma cruzi DNA topoisomerase II, putative 0.0143 0.0317 0.0509
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.0089
Echinococcus multilocularis expressed conserved protein 0.0274 0.0632 0.1026
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0117 0.0184
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0069 0.1022
Brugia malayi glutathione reductase 0.0037 0.0063 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0042 0.0068
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0046 0.0187
Echinococcus multilocularis Niemann Pick C1 protein 0.0416 0.0976 0.1583
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0142 0.2104
Trichomonas vaginalis endoplasmin, putative 0.0143 0.0317 0.5822
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0084 0.0338
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.0501 0.0813
Brugia malayi AMP-binding enzyme family protein 0.007 0.0142 0.023
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0004 0.0058
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0092 0.0095
Schistosoma mansoni hypothetical protein 0.0047 0.0086 0.0139
Trypanosoma cruzi DNA topoisomerase II, putative 0.0143 0.0317 0.0509
Brugia malayi AMP-binding enzyme family protein 0.007 0.0142 0.023
Plasmodium falciparum heat shock protein 90 0.0143 0.0317 0.4673
Echinococcus granulosus chromobox protein 1 0.0069 0.0139 0.0225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0146 0.0236
Loa Loa (eye worm) oxidoreductase 0.0021 0.0023 0.0037
Schistosoma mansoni polycystin 1-related 0.0019 0.002 0.0032
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Mycobacterium leprae Probable two component sensor kinase MprB 0.0143 0.0317 0.449
Echinococcus multilocularis sterol regulatory element binding protein 0.0125 0.0274 0.0445
Brugia malayi SET domain containing protein 0.0013 0.0004 0.0007
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.002 0.029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0143 0.0317 0.5822
Leishmania major developmentally regulated phosphoprotein-like protein 0.2569 0.6165 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0016 0.0295
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0025
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0146 0.0153
Schistosoma mansoni heat shock protein 0.0143 0.0317 0.0515
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0023 0.0037
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0143 0.0317 0.449
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi MH2 domain containing protein 0.0118 0.0256 0.0416
Plasmodium vivax hypothetical protein, conserved 0.0293 0.0679 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2569 0.6165 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0142 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Entamoeba histolytica heat shock protein 90, putative 0.0143 0.0317 0.4702
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0293 0.0679 0.1101
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.002 0.0032
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0088 0.0142
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0124 0.0501
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0178 0.0187
Echinococcus granulosus muscleblind protein 0.0147 0.0328 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0075
Trypanosoma cruzi heat shock protein 85, putative 0.0143 0.0317 0.0509
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0295
Loa Loa (eye worm) hypothetical protein 0.0072 0.0146 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0293 0.0679 0.0727
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0139 0.2544
Onchocerca volvulus 0.0018 0.0015 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0058 0.0094
Plasmodium vivax DNA gyrase subunit B, putative 0.0143 0.0317 0.4673
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.002 0.029
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0328 0.0532
Trichomonas vaginalis sensor histidine kinase, putative 0.0143 0.0317 0.5822
Onchocerca volvulus 0.0293 0.0679 0.1891
Plasmodium falciparum protoporphyrinogen oxidase 0.0293 0.0679 1
Onchocerca volvulus 0.0042 0.0073 0.0205
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0337 0.0546
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0143 0.0317 1
Brugia malayi TspO/MBR family protein 0.1501 0.3591 0.5825
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.003 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0086 0.0139
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0143 0.0317 0.0515
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.052 0.0844
Loa Loa (eye worm) acetyltransferase 0.0151 0.0337 0.0546
Echinococcus multilocularis cpg binding protein 0.0033 0.0052 0.0085
Trichomonas vaginalis receptor histidine kinase, putative 0.0143 0.0317 0.5822
Loa Loa (eye worm) hypothetical protein 0.0143 0.0317 0.0515
Onchocerca volvulus 0.0072 0.0146 0.0406
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.0099 0.1462
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0178 0.0187
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0142 0.0138
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0062
Loa Loa (eye worm) hypothetical protein 0.0054 0.0104 0.0168
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0009 0.0014
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0023 0.0019
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0023 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0087 0.0141
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Echinococcus multilocularis chromobox protein 1 0.0069 0.0139 0.0225
Brugia malayi Pre-SET motif family protein 0.003 0.0046 0.0075
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0898 0.2138 0.3463
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0087 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0087 0.0141
Loa Loa (eye worm) TK/ALK protein kinase 0.0019 0.0018 0.003
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0146 0.0153
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0062
Plasmodium vivax glutathione reductase, putative 0.0037 0.0063 0.0922
Loa Loa (eye worm) hypothetical protein 0.0293 0.0679 0.1101
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Echinococcus granulosus neuropeptide receptor A26 0.1399 0.3345 0.5426
Schistosoma mansoni inositol monophosphatase 0.0036 0.0059 0.0096
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0476 0.0772
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Brugia malayi hypothetical protein 0.0018 0.0015 0.0025
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0143 0.0317 1
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0337 0.0546
Onchocerca volvulus 0.0018 0.0015 0.0042
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0064 0.0104
Echinococcus multilocularis carbonic anhydrase 0.0219 0.0501 0.0813
Trypanosoma cruzi UDP-galactopyranose mutase 0.0293 0.0679 0.1096
Trypanosoma cruzi UDP-galactopyranose mutase 0.0293 0.0679 0.1096
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0142 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0006
Onchocerca volvulus 0.007 0.0142 0.0396
Echinococcus multilocularis GPCR, family 2 0.0047 0.0086 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Brugia malayi chromobox protein homolog 3 0.0039 0.0066 0.0107
Loa Loa (eye worm) hypothetical protein 0.1501 0.3591 0.5825
Brugia malayi PHD-finger family protein 0.003 0.0045 0.0073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0127 0.0207
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0146 0.0142
Brugia malayi hypothetical protein 0.0019 0.0018 0.003
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0023 0.003
Brugia malayi Probable DNA topoisomerase II 0.0143 0.0317 0.0515
Loa Loa (eye worm) hypothetical protein 0.0125 0.0274 0.0445
Schistosoma mansoni zinc finger protein 0.0025 0.0032 0.0052
Mycobacterium tuberculosis Conserved protein 0.0072 0.0146 0.0153
Onchocerca volvulus 0.0019 0.002 0.0055
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0312 0.0725 0.1176
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0088 0.0142
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0023 0.0091
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0023 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0146 0.2674
Echinococcus granulosus translocator protein 0.1501 0.3591 0.5825
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0143 0.0317 0.0337
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0059 0.1083
Loa Loa (eye worm) hypothetical protein 0.0101 0.0216 0.0351
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0023 0.0334
Leishmania major carbonic anhydrase-like protein 0.0312 0.0725 0.117
Plasmodium falciparum DNA topoisomerase 2 0.0143 0.0317 0.4673
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0104 0.0168
Onchocerca volvulus 0.0024 0.0032 0.0088
Schistosoma mansoni hypothetical protein 0.012 0.0263 0.0427
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0087 0.0141
Echinococcus granulosus Niemann Pick C1 protein 0.0416 0.0976 0.1583
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0143 0.0317 0.0337
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0023 0.003
Mycobacterium ulcerans dehydrogenase 0.0293 0.0679 0.0675
Brugia malayi hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0063 0.0102
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0256 0.0416
Leishmania major hypothetical protein, conserved 0.0143 0.0317 0.0509
Mycobacterium tuberculosis Probable two component sensor kinase 0.0143 0.0317 0.0337
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0025
Schistosoma mansoni hypothetical protein 0.0047 0.0086 0.0139
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0142 0.0138
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0259 0.042
Mycobacterium tuberculosis Conserved protein 0.0072 0.0146 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0007 0.0137
Trypanosoma cruzi heat shock protein 90, putative 0.0143 0.0317 0.0509
Onchocerca volvulus 0.003 0.0046 0.0127
Brugia malayi Trypsin family protein 0.0112 0.0243 0.0395
Schistosoma mansoni hypothetical protein 0.0015 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0112 0.0243 0.0395
Onchocerca volvulus 0.1501 0.3591 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0146 0.0236
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0143 0.0317 0.0337
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0023 0.0037
Toxoplasma gondii histone lysine-specific demethylase 0.0293 0.0679 0.2736
Onchocerca volvulus 0.0103 0.0221 0.0616
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0073 0.1337
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0146 0.0153
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi Niemann-Pick C1 protein precursor 0.0291 0.0675 0.1095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0046 0.0075
Onchocerca volvulus 0.0021 0.0023 0.0063
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0219 0.0501 0.0813
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0142 0.0138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0329 0.0534
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0117 0.019
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0104 0.0169
Brugia malayi beta-lactamase family protein 0.0072 0.0146 0.0236
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0229 0.0372
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0032
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0139 0.2544
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Onchocerca volvulus 0.0018 0.0015 0.0043
Mycobacterium tuberculosis Probable reductase 0.0085 0.0178 0.0187
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0126 0.0204
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0143 0.0317 0.0515
Echinococcus granulosus sterol regulatory element binding protein 0.0125 0.0274 0.0445
Schistosoma mansoni amine oxidase 0.0293 0.0679 0.1101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0023 0.0019
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0059 0.1083
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0161
Schistosoma mansoni hypothetical protein 0.0106 0.0229 0.0372
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0009 0.0014
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0023 0.0019
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.02 0.0211
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0143 0.0317 0.0884
Loa Loa (eye worm) hypothetical protein 0.007 0.0142 0.023
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.002 0.0032
Echinococcus multilocularis protoporphyrinogen oxidase 0.0293 0.0679 0.1101
Loa Loa (eye worm) MBCTL1 0.0054 0.0104 0.0168
Schistosoma mansoni hypothetical protein 0.0219 0.0501 0.0813
Trypanosoma cruzi heat shock protein 85, putative 0.0143 0.0317 0.0509
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.005 0.005
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.0501 0.0813
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.1041 0.2482 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.052 0.0844
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0256 0.0416
Onchocerca volvulus 0.0018 0.0015 0.0043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0229 0.0372
Echinococcus granulosus GPCR family 2 0.0047 0.0086 0.0139
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0088 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0146 0.023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0058 0.0094
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0295
Brugia malayi Patched related family protein 12 0.0018 0.0015 0.0025
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0293 0.0679 0.1101
Echinococcus multilocularis 0.0293 0.0679 0.1101
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0534 0.0867
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0293 0.0679 1
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0025
Entamoeba histolytica hypothetical protein 0.0106 0.0229 0.3399
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0295 0.0683 0.2753
Echinococcus granulosus neuropeptide s receptor 0.1399 0.3345 0.5426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.052 0.0844
Schistosoma mansoni DNA topoisomerase II 0.0143 0.0317 0.0515
Entamoeba histolytica hypothetical protein 0.0106 0.0229 0.3399
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0086 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0073 0.1337
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.0099 0.0103
Onchocerca volvulus 0.0018 0.0015 0.0042
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0143 0.0317 0.4642
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0063 0.0095
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0143 0.0317 0.5822
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0023 0.0019
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0022 0.0035
Onchocerca volvulus 0.0072 0.0146 0.0406
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0002 0.0003
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0143 0.0317 0.0884
Onchocerca volvulus Protein patched homolog 0.0018 0.0015 0.0043
Mycobacterium ulcerans two component regulator - sensor kinase 0.0143 0.0317 0.0313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium ulcerans two component sensor kinase MprB 0.0143 0.0317 0.0313
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0142 0.182
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0143 0.0317 0.5822
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0178 0.0187
Loa Loa (eye worm) hypothetical protein 0.0048 0.0088 0.0142
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0117 0.019
Plasmodium falciparum endoplasmin, putative 0.0143 0.0317 0.4673
Brugia malayi amine oxidase, flavin-containing family protein 0.0293 0.0679 0.1101
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0142 0.0224
Echinococcus multilocularis carbonic anhydrase II 0.0312 0.0725 0.1176
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0023 0.0019
Trypanosoma cruzi ISWI complex protein 0.0015 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0098 0.0208 0.0338
Echinococcus granulosus carbonic anhydrase 0.0219 0.0501 0.0813
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0143 0.0317 0.0337
Echinococcus granulosus lysine specific histone demethylase 1A 0.0293 0.0679 0.1101
Echinococcus granulosus expressed conserved protein 0.0274 0.0632 0.1026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0084 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Plasmodium vivax endoplasmin, putative 0.0143 0.0317 0.4673
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.052 0.0844
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.416 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.052 0.0844
Brugia malayi Patched related family protein 10 0.0018 0.0015 0.0025
Schistosoma mansoni zinc finger protein 0.0015 0.0009 0.0015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0142 0.0138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.052 0.0844
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.052 0.0844
Schistosoma mansoni hypothetical protein 0.0101 0.0216 0.0351
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0063 0.0922
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0143 0.0317 0.0509
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0023 0.0019
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0143 0.0317 0.1278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0086 0.0139
Onchocerca volvulus 0.0098 0.0208 0.058
Plasmodium falciparum thioredoxin reductase 0.0037 0.0063 0.0922
Onchocerca volvulus 0.0019 0.0018 0.0051
Loa Loa (eye worm) doublecortin family protein 0.0019 0.002 0.0032
Onchocerca volvulus 0.1501 0.3591 1
Onchocerca volvulus 0.0112 0.0243 0.0678
Schistosoma mansoni carbonic anhydrase 0.0219 0.0501 0.0813
Echinococcus multilocularis RUN 0.0019 0.002 0.0032
Echinococcus multilocularis muscleblind protein 0.0147 0.0328 0.0532
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0059 0.0238
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0293 0.0679 1
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0898 0.2138 0.3463
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0062
Brugia malayi Inositol-1 0.0036 0.0059 0.0096
Echinococcus granulosus dnaJ subfamily B 0.0419 0.0983 0.1595
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0052 0.0099 0.1412
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0059 0.0096
Onchocerca volvulus 0.0018 0.0015 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0117 0.019
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.24 0.5758 0.934
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0004 0.0058
Mycobacterium ulcerans hypothetical protein 0.0072 0.0146 0.0142
Onchocerca volvulus 0.0018 0.0015 0.0042
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.002 0.0032
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Brugia malayi Muscle positioning protein 4 0.0018 0.0015 0.0024
Brugia malayi Thioredoxin reductase 0.0037 0.0063 0.0102
Brugia malayi Doublecortin family protein 0.0019 0.002 0.0032
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0139 0.0225
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0146 0.0236
Loa Loa (eye worm) hypothetical protein 0.0047 0.0087 0.0141
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0015 0.0227
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.003 0.0049
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0084 0.1234
Onchocerca volvulus 0.0237 0.0545 0.1518
Echinococcus multilocularis tumor protein p63 0.0667 0.1581 0.2564
Mycobacterium ulcerans DNA gyrase subunit B 0.0143 0.0317 0.0313
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.3867 0.9294 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0296 0.0686 0.1112
Leishmania major trypanothione reductase 0.0037 0.0063 0.0095
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.002 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0117 0.0472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.052 0.0844
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0086 0.0139
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0161
Schistosoma mansoni pyruvate dehydrogenase 0.2569 0.6165 1
Trypanosoma brucei heat shock protein, putative 0.0143 0.0317 0.0509
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.0022
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0073 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0066 0.1207
Brugia malayi CHD4 protein 0.0015 0.0009 0.0014
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0024 0.0038
Entamoeba histolytica hypothetical protein 0.0106 0.0229 0.3399
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Schistosoma mansoni hypothetical protein 0.012 0.0263 0.0427
Echinococcus granulosus Niemann Pick C1 protein 0.0291 0.0675 0.1095
Brugia malayi CHE-14 protein 0.0125 0.0274 0.0445
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0146 0.2674
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0139
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0142 0.0149
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0161
Brugia malayi SWIRM domain containing protein 0.0293 0.0679 0.1101
Echinococcus multilocularis MAM 0.0019 0.0018 0.003
Schistosoma mansoni hypothetical protein 0.0047 0.0086 0.0139
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0127 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0117 0.0113
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0143 0.0317 0.5822
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.003
Brugia malayi SEA domain containing protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.052 0.0844
Trypanosoma brucei carbonic anhydrase-like protein 0.0312 0.0725 0.117
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0023 0.0037
Echinococcus multilocularis protein patched 0.0125 0.0274 0.0445
Toxoplasma gondii heat shock protein 90, putative 0.0143 0.0317 0.1278
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trypanosoma cruzi heat shock protein 85, putative 0.0143 0.0317 0.0509
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.002 0.0032
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0104 0.0168
Mycobacterium ulcerans monoamine oxidase 0.0293 0.0679 0.0675
Schistosoma mansoni inositol monophosphatase 0.0036 0.0059 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0534 0.0867
Onchocerca volvulus 0.0018 0.0015 0.0043
Loa Loa (eye worm) beta-lactamase 0.0072 0.0146 0.0236
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0143 0.0317 0.0337
Brugia malayi beta-lactamase 0.0072 0.0146 0.0236
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0426 0.0691
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0178 0.0187
Giardia lamblia Heat shock protein HSP 90-alpha 0.0143 0.0317 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0143 0.0317 0.4673
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0023 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0295
Schistosoma mansoni lipoxygenase 0.0019 0.002 0.0032
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi follicle stimulating hormone receptor 0.0462 0.1086 0.1762
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0146 0.0236
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0059 0.0096
Echinococcus granulosus Chromobox protein 3 0.0011 0.0000000030118 0.0000000048854
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0178 0.2362
Echinococcus multilocularis neuropeptide s receptor 0.1399 0.3345 0.5426
Entamoeba histolytica DNA topoisomerase II, putative 0.0143 0.0317 0.4702
Echinococcus multilocularis carbonic anhydrase 0.0219 0.0501 0.0813
Trypanosoma brucei DNA topoisomerase ii 0.0143 0.0317 0.0509
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Echinococcus granulosus MAM 0.0019 0.0018 0.003
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0104 0.0169
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0178 0.0187
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0142 0.0138
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0143 0.0317 0.449
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0291 0.0675 1
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Brugia malayi CXXC zinc finger family protein 0.0029 0.0044 0.0071
Mycobacterium tuberculosis Possible two component sensor kinase 0.0143 0.0317 0.0337
Leishmania major heat shock protein 83-1 0.0143 0.0317 0.0509
Onchocerca volvulus 0.0018 0.0015 0.0043
Trypanosoma cruzi Heat shock protein 83, putative 0.0143 0.0317 0.0509
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0142 0.0224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0092 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0146 0.0236
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0004 0.0006
Echinococcus granulosus RUN 0.0019 0.002 0.0032
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0143 0.0317 0.1278
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.0089
Schistosoma mansoni endoplasmin 0.0143 0.0317 0.0515
Brugia malayi Bromodomain containing protein 0.0041 0.0073 0.0118
Brugia malayi Patched family protein 0.0018 0.0015 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0146 0.2146
Loa Loa (eye worm) hypothetical protein 0.0072 0.0146 0.0236
Mycobacterium ulcerans tryptophan-rich sensory protein 0.1501 0.3591 0.3588
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0062
Onchocerca volvulus 0.1501 0.3591 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0293 0.0679 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0312 0.0725 0.117
Loa Loa (eye worm) hypothetical protein 0.0147 0.0328 0.0532
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0143 0.0317 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0709
Brugia malayi hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0023 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0086 0.0139
Schistosoma mansoni pyruvate dehydrogenase 0.2426 0.582 0.9441
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0087 0.0141
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0023 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0092 0.0095
Brugia malayi hypothetical protein 0.0019 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0153 0.0342 0.0555
Schistosoma mansoni chromobox protein 0.0069 0.0139 0.0225
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0143 0.0317 0.0313
Plasmodium falciparum thioredoxin reductase 0.0013 0.0004 0.0058
Toxoplasma gondii DNA topoisomerase 2, putative 0.0143 0.0317 0.1278
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0023 0.003
Toxoplasma gondii heat shock protein HSP90 0.0143 0.0317 0.1278
Brugia malayi Bromodomain containing protein 0.0079 0.0164 0.0266
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0143 0.0317 0.0313
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0084 0.1537
Schistosoma mansoni patched 1 0.0125 0.0274 0.0445
Schistosoma mansoni pyruvate dehydrogenase 0.2426 0.582 0.9441
Echinococcus multilocularis translocator protein 0.1501 0.3591 0.5825
Trichomonas vaginalis esterase, putative 0.0072 0.0146 0.2674
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0709
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0004 0.0058
Brugia malayi hypothetical protein 0.0233 0.0534 0.0867
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0161
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.1077 0.1155
Loa Loa (eye worm) hypothetical protein 0.0148 0.0329 0.0534
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.0501 0.0813
Mycobacterium tuberculosis Conserved protein 0.0143 0.0317 0.0337
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0146 0.0142
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0143 0.0317 0.0313
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0337 0.0546

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 50 uM Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay ChEMBL. 25554367

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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