Detailed information for compound 949521

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 284.389 | Formula: C15H21FO2S
  • H donors: 1 H acceptors: 1 LogP: 2.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSC[C@H]1O[C@H](C[C@@](C1)(C)O)c1ccc(cc1)F
  • InChi: 1S/C15H21FO2S/c1-3-19-10-13-8-15(2,17)9-14(18-13)11-4-6-12(16)7-5-11/h4-7,13-14,17H,3,8-10H2,1-2H3/t13-,14+,15-/m0/s1
  • InChiKey: FECQFEVAJTTZDO-ZNMIVQPWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Ovis aries Cyclooxygenase-1 Starlite/ChEMBL References
Ovis aries Cyclooxygenase-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.1073 0.107
Entamoeba histolytica cysteine surface protein, putative 0.0006 0.0015 0.0105
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0076 0.1111 0.1989
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0007 0.0041 0.0067
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Onchocerca volvulus 0.0008 0.0044 0.0029
Entamoeba histolytica hypothetical protein 0.0035 0.0473 0.3433
Echinococcus multilocularis tyrosine protein kinase shark 0.001 0.0077 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0401 0.0398
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0401 0.0715
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0401 0.0715
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0163 0.2458 0.2745
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0076 0.1111 0.1989
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Brugia malayi SH3 domain containing protein 0.0007 0.0041 0.0038
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.015 0.0147
Brugia malayi beta-lactamase family protein 0.0039 0.0534 0.0531
Echinococcus granulosus SH2 motif 0.0008 0.0044 0.0073
Brugia malayi MH1 domain containing protein 0.0008 0.0049 0.0046
Brugia malayi nuclear hormone receptor 0.0014 0.015 0.0147
Loa Loa (eye worm) steroid hormone receptor 0.0175 0.2651 0.2648
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0159 0.0156
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0534 0.3779
Loa Loa (eye worm) hypothetical protein 0.0095 0.1408 0.1405
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0008 0.0044 0.0073
Entamoeba histolytica protein kinase, putative 0.0007 0.0041 0.0296
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Brugia malayi STAT protein, DNA binding domain containing protein 0.0008 0.0044 0.004
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0193 0.034
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Echinococcus granulosus expressed protein 0.0033 0.0433 0.0772
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0014 0.0136 0.099
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0193 0.034
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0549 0.3977
Brugia malayi steroid hormone receptor 0.0175 0.2651 0.2648
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0401 0.0715
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0603 0.1077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0549 0.3895
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0534 0.047
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0022 0.0018
Brugia malayi beta-lactamase 0.0039 0.0534 0.0531
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0193 0.034
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0014 0.0136 0.0847
Onchocerca volvulus 0.001 0.0077 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Loa Loa (eye worm) hypothetical protein 0.0648 1 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.006 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0401 0.0398
Onchocerca volvulus 0.0095 0.1406 0.1394
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.006 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Brugia malayi hypothetical protein 0.0029 0.0382 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0401 0.0398
Schistosoma mansoni Smad4 0.0008 0.0049 0.0082
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0022 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0014 0.015 0.0263
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0017 0.0024
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.008 0.0557
Entamoeba histolytica SH2-protein kinase domain containing protein 0.001 0.0077 0.0559
Onchocerca volvulus Putative cortactin 0.0007 0.0041 0.0026
Brugia malayi hypothetical protein 0.0019 0.022 0.0217
Schistosoma mansoni peroxidasin 0.0095 0.1406 0.2518
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1362 0.244
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1111 0.1989
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.1362 0.244
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1073 0.192
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0057
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0549 0.8423
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0102 0.0595
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0401 0.0715
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0193 0.034
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1406 0.1403
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0401 0.0715
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Schistosoma mansoni apoptosis stimulating of P53 0.0007 0.0041 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0382 0.5839
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0022 0.0018
Brugia malayi Protein kinase domain containing protein 0.001 0.0077 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0401 0.0398
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Brugia malayi tRNA modification GTPase TrmE family protein 0.0008 0.0044 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0401 0.0715
Schistosoma mansoni vav2 0.0008 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0379
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0484 0.0411
Onchocerca volvulus 0.0039 0.0534 0.052
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0133 0.013
Schistosoma mansoni NAD dehydrogenase 0.0014 0.0136 0.0239
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0008 0.0044 0.0073
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0008 0.0044 0.004
Onchocerca volvulus 0.0013 0.0133 0.0119
Schistosoma mansoni fad oxidoreductase 0.0014 0.0136 0.0239
Schistosoma mansoni eps8-related protein 0.0007 0.0041 0.0067
Schistosoma mansoni hypothetical protein 0.0008 0.0044 0.0073
Brugia malayi RasGEF domain containing protein 0.0006 0.0022 0.0018
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0014 0.0136 0.0239
Brugia malayi Protein kinase domain containing protein 0.001 0.0077 0.0074
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0603 0.4293
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Echinococcus granulosus nostrin 0.0007 0.0041 0.0067
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0007 0.0041 0.0067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0473 0.0843
Loa Loa (eye worm) guanylate kinase 0.0007 0.0041 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.015 0.0263
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.015 0.0263
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0542 0.0539
Schistosoma mansoni GTPase activating protein 0.0008 0.0044 0.0073
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0014 0.0136 0.0239
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0534 0.0531
Schistosoma mansoni tensin 0.0008 0.0044 0.0073
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0041 0.0038
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0542 0.0539
Schistosoma mansoni hypothetical protein 0.0363 0.5574 1
Onchocerca volvulus 0.0014 0.015 0.0135
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.006 0.0103
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.006 0.0057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0549 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0102 0.0595
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0044 0.004
Loa Loa (eye worm) TK protein kinase 0.0069 0.0995 0.0993
Brugia malayi Fes/CIP4 homology domain containing protein 0.0007 0.0041 0.0038
Onchocerca volvulus 0.0007 0.0041 0.0026
Chlamydia trachomatis D-amino acid dehydrogenase 0.0014 0.0136 0.5
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0603 0.1077
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.015 0.0147
Entamoeba histolytica protein kinase, putative 0.0006 0.0015 0.0105
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Loa Loa (eye worm) hypothetical protein 0.0039 0.0534 0.0531
Echinococcus multilocularis smad 0.0008 0.0049 0.0082
Onchocerca volvulus 0.0039 0.0534 0.052
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1742 0.1739
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.015 0.0263
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0534 0.0531
Brugia malayi Myosin tail family protein 0.0007 0.0041 0.0038
Brugia malayi beta-lactamase family protein 0.0039 0.0534 0.0531
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0076 0.1111 0.1989
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0401 0.0398
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0542 0.0967
Brugia malayi hypothetical protein 0.0008 0.0044 0.004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0401 0.0398
Echinococcus multilocularis tyrosine protein kinase HCK 0.0061 0.0877 0.1568
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0401 0.0715
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0211 0.0089
Schistosoma mansoni tensin 0.0008 0.0044 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0603 0.1077
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1377 0.1364
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0014 0.0136 0.0847
Onchocerca volvulus 0.0008 0.0044 0.0029
Onchocerca volvulus 0.0648 1 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0211 0.0374
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0008 0.0044 0.0029
Brugia malayi SH2 domain containing protein 0.001 0.0077 0.0074
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.013 0.0228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Brugia malayi Protein kinase domain containing protein 0.0006 0.0015 0.0011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0401 0.0387
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Brugia malayi Guanylate kinase family protein 0.0007 0.0041 0.0038
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0014 0.0136 0.0715
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0603 0.4382
Brugia malayi hypothetical protein 0.0035 0.0473 0.047
Loa Loa (eye worm) blistered cuticle protein 3 0.0095 0.1406 0.1403
Mycobacterium ulcerans beta-lactamase 0.0039 0.0534 0.047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0549 0.3895
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0473 0.0843
Entamoeba histolytica hypothetical protein 0.0011 0.0102 0.0742
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1073 0.192
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0401 0.0715
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0382 0.2659
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.0983 0.1759
Echinococcus granulosus peroxidasin 0.0095 0.1408 0.2522
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0076 0.1111 0.1989
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.1366 0.2447
Echinococcus granulosus src region 0.0007 0.0041 0.0067
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0163 0.2458 0.2745
Echinococcus granulosus geminin 0.0363 0.5574 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0077 0.113 0.2022
Entamoeba histolytica protein kinase, putative 0.0009 0.0062 0.0454
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0007 0.0041 0.0067
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0159 0.0156
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0645 0.4685
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1406 0.1403
Schistosoma mansoni suppressor of cytokine signaling 0.0008 0.0044 0.0073
Loa Loa (eye worm) inositol-1 0.004 0.0549 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0534 0.0531
Echinococcus granulosus suppressor of cytokine signaling 7 0.0008 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Onchocerca volvulus Peroxidasin homolog 0.0095 0.1408 0.1395
Trypanosoma brucei wee1-like protein kinase 0.0056 0.0799 0.5679
Trichomonas vaginalis rotamase, putative 0.0032 0.0421 0.2951
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0014 0.0136 0.2052
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0401 0.0387
Echinococcus granulosus son of sevenless 1 0.0006 0.0022 0.0033
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0534 0.0952
Loa Loa (eye worm) p53BP2 0.0007 0.0041 0.0038
Echinococcus granulosus expressed protein 0.0047 0.0652 0.1164
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0022 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0603 0.4293
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.015 0.0147
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0076 0.1111 0.1989
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.015 0.0263
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0008 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0008 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0057
Echinococcus multilocularis tyrosine protein kinase Srms 0.0069 0.0995 0.1781
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0007 0.0041 0.0026
Schistosoma mansoni tensin-related 0.0008 0.0044 0.0073
Echinococcus granulosus tar DNA binding protein 0.0074 0.1073 0.192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0401 0.0398
Brugia malayi MH1 domain containing protein 0.0008 0.0049 0.0046
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1377 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0049 0.0082
Schistosoma mansoni tsg101-related 0.0046 0.0645 0.1152
Mycobacterium tuberculosis Conserved protein 0.0039 0.0534 0.047
Onchocerca volvulus 0.0009 0.006 0.0046
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1111 0.1989
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.008 0.0429
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0603 0.1077
Echinococcus multilocularis expressed protein 0.0033 0.0433 0.0772
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0652 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0603 0.1077
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0008 0.0044 0.0073
Schistosoma mansoni hypothetical protein 0.0013 0.013 0.0228
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0022 0.0033
Entamoeba histolytica hypothetical protein, conserved 0.0006 0.0015 0.0105
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.006 0.0103
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0534 0.771
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0534 0.0531
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1377 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Brugia malayi ecdysteroid receptor 0.0031 0.0401 0.0398
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0401 0.0387
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0603 0.4211
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1073 0.192
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0421 0.3061
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0044 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0534 0.0952
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1073 0.192
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0603 0.3765
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0177 0.0311
Echinococcus granulosus tyrosine protein kinase HCK 0.0061 0.0877 0.1568
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1377 0.2465
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0534 0.3779
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0401 0.0398
Loa Loa (eye worm) hypothetical protein 0.0177 0.2672 0.267
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1377 0.1374
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0049 0.0046
Onchocerca volvulus 0.0031 0.0401 0.0387
Loa Loa (eye worm) protein-tyrosine kinase 0.0007 0.0041 0.0038
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0421 0.2951
Schistosoma mansoni dreadlocks/dock 0.0007 0.0041 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.013 0.1945 0.2138
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1377 0.2465
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Schistosoma mansoni kinase 0.0048 0.067 0.1196
Trichomonas vaginalis p67phox protein, putative 0.0007 0.0041 0.0142
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0014 0.0136 0.0239
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0211 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0401 0.0398
Echinococcus granulosus endophilin A3 0.0007 0.0041 0.0067
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0652 0.0649
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.015 0.0263
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0382 0.4765
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Brugia malayi conserved hypotetical protein 0.0014 0.015 0.0147
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0018
Entamoeba histolytica hypothetical protein 0.0011 0.0102 0.0742
Schistosoma mansoni zinc finger protein 0.0014 0.015 0.0263
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0652 0.1164
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0159 0.0156
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1406 0.1403
Onchocerca volvulus 0.0095 0.1406 0.1394
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.0894 0.0897
Schistosoma mansoni formin binding protein and related proteins 0.0007 0.0041 0.0067
Schistosoma mansoni nuclear receptor 0.0014 0.015 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0007 0.0041 0.0067
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0008 0.0044 0.0073
Loa Loa (eye worm) Smad1 0.0008 0.0049 0.0046
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0008 0.0044 0.0073
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0014 0.0136 0.0133
Onchocerca volvulus 0.0007 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.2672 0.2662
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.0894 0.0897
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0009 0.0062 0.0454
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Schistosoma mansoni cell polarity protein 0.0007 0.0041 0.0067
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0542 0.8308
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.006 0.0103
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0211 0.1516
Schistosoma mansoni adapter molecule crk 0.0015 0.0159 0.028
Echinococcus granulosus tyrosine protein kinase Srms 0.001 0.0077 0.0132
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0534 0.047
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0557 0.8593 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1377 1
Brugia malayi hypothetical protein 0.0016 0.0177 0.0174
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0008 0.0044 0.0073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.015 0.0263
Leishmania major hypothetical protein, conserved 0.0014 0.0136 0.0969
Schistosoma mansoni coup transcription factor 0.0031 0.0401 0.0715
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0401 0.0715
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0022 0.0033
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Onchocerca volvulus 0.0008 0.0044 0.0029
Brugia malayi Protein kinase domain containing protein 0.001 0.0077 0.0074
Echinococcus multilocularis endophilin A3 0.0007 0.0041 0.0067
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0421 0.645
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0174
Brugia malayi nuclear receptor NHR-67 0.0014 0.015 0.0147
Schistosoma mansoni tyrosine kinase 0.0076 0.1111 0.1989
Trichomonas vaginalis rotamase, putative 0.0033 0.0433 0.3039
Schistosoma mansoni peroxidasin 0.0095 0.1408 0.2522
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0382 0.2659
Brugia malayi MH2 domain containing protein 0.0117 0.1742 0.1739
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0603 0.3765
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0049 0.0082
Brugia malayi hypothetical protein 0.0036 0.0482 0.0479
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.013 0.1945 0.2138
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0076 0.1111 0.1989
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1377 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0159 0.028
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0193 0.034
Echinococcus multilocularis Smad4 0.0008 0.0049 0.0082
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Schistosoma mansoni sorting nexin 0.0007 0.0041 0.0067
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0014 0.0136 0.0715
Brugia malayi MH2 domain containing protein 0.0008 0.0049 0.0046
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1406 0.1403
Brugia malayi hypothetical protein 0.0016 0.0177 0.0174
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0008 0.0044 0.004
Toxoplasma gondii hypothetical protein 0.0009 0.006 0.0881
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0177 0.0311
Schistosoma mansoni tyrosine kinase 0.001 0.0077 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0401 0.0715
Brugia malayi RNA binding protein 0.0074 0.1073 0.107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0401 0.0715
Onchocerca volvulus 0.0095 0.1406 0.1394
Echinococcus granulosus tyrosine kinase 0.0069 0.0995 0.1781
Echinococcus multilocularis SHC transforming protein 3 0.0008 0.0044 0.0073
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0014 0.0136 0.0847
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0159 0.028
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0557 0.8593 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0549 0.0488
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0007 0.0041 0.0067
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Echinococcus multilocularis geminin 0.0363 0.5574 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0007 0.0041 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0549 0.3895
Entamoeba histolytica protein kinase, putative 0.0061 0.0877 0.6373
Schistosoma mansoni smad1 5 8 and 0.0008 0.0049 0.0082
Onchocerca volvulus 0.001 0.0077 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0401 0.0398
Brugia malayi cell division control protein 2 homolog 0.0044 0.0603 0.06
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.015 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0401 0.0398
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0652 1
Schistosoma mansoni hypothetical protein 0.004 0.0542 0.0967
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1362 0.244
Schistosoma mansoni tyrosine kinase 0.0017 0.0193 0.034
Onchocerca volvulus 0.0014 0.015 0.0135
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Onchocerca volvulus Peroxidasin homolog 0.0095 0.1406 0.1394
Schistosoma mansoni shc transforming protein 0.0008 0.0044 0.0073
Onchocerca volvulus 0.0008 0.0044 0.0029
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0534 0.3779
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0177 0.0174
Entamoeba histolytica hypothetical protein 0.0011 0.0102 0.0742
Echinococcus multilocularis tensin 0.0008 0.0044 0.0073
Loa Loa (eye worm) DR-78 0.0014 0.015 0.0147
Echinococcus granulosus expressed conserved protein 0.0008 0.0044 0.0073
Brugia malayi DIX domain containing protein 0.0009 0.006 0.0057
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0484 0.0411
Entamoeba histolytica hypothetical protein 0.0035 0.0473 0.3433
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.006 0.0103
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0008 0.0044 0.0073
Schistosoma mansoni C-fyn 0.0007 0.0041 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.015 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0211 0.0208
Brugia malayi protein-tyrosine kinase 0.0007 0.0041 0.0038
Brugia malayi cDNA sequence BC016226 0.0014 0.0136 0.0133
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0057
Schistosoma mansoni tsg101-related 0.0057 0.0806 0.1442
Onchocerca volvulus 0.001 0.0077 0.0063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0049 0.0082
Schistosoma mansoni tensin-related 0.0008 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0163 0.2458 0.2455
Echinococcus multilocularis 0.0008 0.0044 0.0073
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.015 0.0147
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0549 0.098
Schistosoma mansoni nuclear hormone receptor 0.0014 0.015 0.0263
Echinococcus granulosus SHC transforming protein 3 0.0008 0.0044 0.0073
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.015 0.0263
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0008 0.0044 0.0073
Echinococcus multilocularis tyrosine protein kinase Blk 0.0069 0.0995 0.1781
Brugia malayi nuclear receptor RXR 0.0014 0.015 0.0147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0174
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0007 0.0041 0.0067
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1406 0.1403
Schistosoma mansoni smad1 5 8 and 0.0008 0.0049 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0651 0.4644
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0008 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0102 0.0595
Echinococcus multilocularis SH2 motif 0.0008 0.0044 0.0073
Echinococcus multilocularis tyrosine protein kinase ABL1 0.001 0.0077 0.0132
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0022 0.0033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.1073 0.107
Onchocerca volvulus Chorion peroxidase homolog 0.0095 0.1406 0.1394
Onchocerca volvulus Dual oxidase homolog 0.0095 0.1406 0.1394
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0044 0.004
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0603 0.1077
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0044 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0401 0.0398
Onchocerca volvulus 0.0009 0.006 0.0045
Brugia malayi hypothetical protein 0.0068 0.0983 0.098
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0401 0.0398
Entamoeba histolytica hypothetical protein, conserved 0.0007 0.0041 0.0296
Leishmania major hypothetical protein, conserved 0.0014 0.0136 0.0969
Brugia malayi Src substrate cortactin 0.0007 0.0041 0.0038
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0008 0.0044 0.0073
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1111 0.1989
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0401 0.0715
Brugia malayi nuclear receptor NHR-88 0.0014 0.015 0.0147
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Schistosoma mansoni hypothetical protein 0.0363 0.5574 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0401 0.0398
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0211 0.0374
Brugia malayi Tensin 0.0008 0.0044 0.004
Schistosoma mansoni inositol monophosphatase 0.004 0.0549 0.098
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.015 0.0263
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1362 0.244
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0041 0.0142
Brugia malayi ecdysone receptor 0.0014 0.015 0.0147
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.015 0.0263
Echinococcus granulosus tyrosine protein kinase Fps85D 0.001 0.0077 0.0132
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Echinococcus granulosus suppressor of cytokine signaling 6 0.0008 0.0044 0.0073
Plasmodium vivax protein kinase Crk2 0.0044 0.0603 0.9061
Entamoeba histolytica hypothetical protein 0.0035 0.0473 0.3433
Schistosoma mansoni hypothetical protein 0.0035 0.0473 0.0843
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.015 0.0263
Schistosoma mansoni dynamin-associated protein 0.0007 0.0041 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Plasmodium falciparum protein kinase 5 0.0044 0.0603 0.9254
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0603 0.4369
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0008 0.0044 0.004
Echinococcus multilocularis N chimaerin 0.0008 0.0044 0.0073
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0007 0.0041 0.0067
Onchocerca volvulus 0.001 0.0077 0.0063
Leishmania major hypothetical protein, conserved 0.0029 0.0382 0.2757
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0041 0.0142
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.015 0.0135
Brugia malayi RhoGAP domain containing protein 0.0008 0.0044 0.004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1111 0.1989
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0603 0.4293
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0014 0.0136 0.0122
Brugia malayi Nuclear hormone receptor E75 0.0014 0.015 0.0147
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0211 0.3211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0401 0.0715
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0014 0.0136 0.0715
Entamoeba histolytica BAR/SH3 domain containing protein 0.0007 0.0041 0.0296
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0049 0.0046
Schistosoma mansoni tsg101-related 0.0057 0.0806 0.1442
Loa Loa (eye worm) hypothetical protein 0.0014 0.0136 0.0133
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0014 0.0136 0.0239
Brugia malayi Protein kinase domain containing protein 0.001 0.0077 0.0074
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1406 0.1403
Brugia malayi nuclear hormone receptor 0.0031 0.0401 0.0398
Brugia malayi nuclear receptor RXR 0.0016 0.0177 0.0174
Brugia malayi N-terminal motif family protein 0.0177 0.2672 0.267
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0534 0.047
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1406 0.1403
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0534 0.3779
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0421 0.285
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0542 0.0539
Loa Loa (eye worm) hypothetical protein 0.0042 0.0584 0.0581
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0557 0.8593 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Schistosoma mansoni tyrosine kinase 0.001 0.0077 0.0132
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Toxoplasma gondii ABC1 family protein 0.0039 0.0534 0.818
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Echinococcus multilocularis peroxidasin 0.0095 0.1408 0.2522
Brugia malayi Nuclear hormone receptor E75 0.0014 0.015 0.0147
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0177 0.0174
Echinococcus granulosus tyrosine protein kinase Src64B 0.0076 0.1111 0.1989
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0014 0.0136 0.0969
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.013 0.0228
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0014 0.0136 0.0133
Schistosoma mansoni hypothetical protein 0.0007 0.0041 0.0067
Onchocerca volvulus Putative fad oxidoreductase 0.0014 0.0136 0.0122
Echinococcus multilocularis signal transduction protein lnk realted 0.0008 0.0044 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.004 0.0542 0.0539
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0401 0.0398
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1362 0.244
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0007 0.0041 0.0067
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.008 0.1179
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0211 0.1401
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0007 0.0041 0.0067
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0534 0.047
Schistosoma mansoni SH2A 0.0008 0.0044 0.0073
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0159 0.0156
Brugia malayi tailless protein 0.0014 0.015 0.0147
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1377 0.1374
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.006 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0401 0.0398
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0014 0.0136 0.0847
Brugia malayi N-terminal motif family protein 0.0006 0.0022 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0433 0.3039
Loa Loa (eye worm) hypothetical protein 0.0068 0.0983 0.098
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Brugia malayi Protein kinase domain containing protein 0.001 0.0077 0.0074
Brugia malayi hypothetical protein 0.0036 0.0482 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0142
Loa Loa (eye worm) SRC-1 0.0076 0.1111 0.1108
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0041 0.0038
Schistosoma mansoni sorbin 0.0007 0.0041 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.006 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0603 0.4293
Schistosoma mansoni dishevelled 0.0009 0.006 0.0103
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.0995 0.1781
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0534 0.3779
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0014 0.0136 0.0847
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1111 0.1989
Onchocerca volvulus 0.0008 0.0044 0.0029
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0603 0.4293
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.008 0.0291
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0534 0.369
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.015 0.0263
Schistosoma mansoni hypothetical protein 0.0008 0.0044 0.0073
Brugia malayi hypothetical protein 0.0009 0.006 0.0057
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.0983 0.1759
Loa Loa (eye worm) beta-lactamase 0.0039 0.0534 0.0531
Echinococcus granulosus tyrosine protein kinase Blk 0.0069 0.0995 0.1781
Brugia malayi hypothetical protein 0.0014 0.015 0.0147
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0603 0.4382
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0211 0.1458
Loa Loa (eye worm) TAR-binding protein 0.0074 0.1073 0.107
Echinococcus granulosus Spectrin alpha actinin 0.0007 0.0041 0.0067
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0652 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0542 0.8308
Brugia malayi Blistered cuticle protein 3 0.0095 0.1406 0.1403
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Echinococcus granulosus tyrosine protein kinase ABL1 0.001 0.0077 0.0132
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0549 0.3807
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0211 0.1277
Echinococcus granulosus fch and double sh3 domains protein 2 0.0007 0.0041 0.0067
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.006 0.0103
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0044 0.004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0401 0.0715
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0008 0.0044 0.0073
Echinococcus multilocularis transfer RNA-Ala 0.0007 0.0041 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0603 0.1077
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0603 0.06
Brugia malayi isocitrate dehydrogenase 0.0018 0.0211 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0401 0.0398
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0401 0.0715
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.015 0.0263
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Echinococcus granulosus thyroid hormone receptor alpha 0.0159 0.2399 0.4301
Echinococcus granulosus SH2 domain containing protein 7 0.0008 0.0044 0.0073
Schistosoma mansoni hypothetical protein 0.0007 0.0041 0.0067
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.006 0.0057
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.015 0.0147
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0603 0.4293
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0076 0.1111 0.1989
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0603 0.4369
Loa Loa (eye worm) hypothetical protein 0.0015 0.0159 0.0156
Brugia malayi hypothetical protein 0.0009 0.006 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0211 0.3211
Entamoeba histolytica SH2 domain containing protein 0.0008 0.0044 0.0317
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0382 0.5839
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0534 0.0952
Loa Loa (eye worm) hypothetical protein 0.0014 0.0136 0.0133
Giardia lamblia Kinase, PLK 0.0093 0.1377 1
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.0894 0.0897
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0603 0.06
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0174
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0603 0.1077
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0041 0.0038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0401 0.0715
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0149 0.2247 0.2496
Echinococcus granulosus Smad4 0.0008 0.0049 0.0082
Echinococcus granulosus tyrosine protein kinase Src42A 0.0076 0.1111 0.1989
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0008 0.0044 0.0029
Onchocerca volvulus 0.001 0.0081 0.0066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0534 0.047
Brugia malayi Inositol-1 0.004 0.0549 0.0546
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0401 0.0715
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0534 0.3779
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0603 0.9254
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0007 0.0041 0.0067
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0007 0.0041 0.0067
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0014 0.0136 0.0133
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0014 0.0136 0.2052
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0007 0.0041 0.0038
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0022 0.0018
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0014 0.0136 0.0715
Echinococcus multilocularis intersectin 2 0.0007 0.0041 0.0067
Mycobacterium ulcerans lipase LipD 0.0039 0.0534 0.047
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0014 0.0136 0.0847
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0211 0.1401
Echinococcus granulosus SH2 domain containing adapter protein F 0.0008 0.0044 0.0073
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0008 0.0044 0.0073
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0193 0.034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0534 0.047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0136 0.0133
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0211 0.0374
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0177 0.0311
Loa Loa (eye worm) TK/ABL protein kinase 0.001 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0534 0.0531
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Echinococcus granulosus NCK adaptor protein 0.0015 0.0159 0.028
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.015 0.0147
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0022 0.0033
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0603 0.06
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0401 0.0398
Echinococcus multilocularis expressed protein 0.0047 0.0652 0.1164
Brugia malayi Protein kinase domain containing protein 0.0044 0.0603 0.06
Loa Loa (eye worm) hypothetical protein 0.0039 0.0534 0.0531
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0174
Brugia malayi MH2 domain containing protein 0.0008 0.0049 0.0046
Echinococcus granulosus epidermal growth factor receptor kinase 0.0007 0.0041 0.0067
Loa Loa (eye worm) thyroid receptor interactor 0.0007 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Schistosoma mansoni rotamase 0.0033 0.0433 0.0772
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0041 0.0038
Echinococcus multilocularis SH2 motif 0.0008 0.0044 0.0073
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Brugia malayi RasGEF domain containing protein 0.0006 0.0022 0.0018
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0022 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0401 0.0715
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0473 0.0843
Echinococcus granulosus intersectin 2 0.0007 0.0041 0.0067
Mycobacterium ulcerans hypothetical protein 0.0039 0.0534 0.047
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0433 0.043
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0014 0.0136 0.0239
Schistosoma mansoni hypothetical protein 0.0093 0.1366 0.2447
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0433 0.043
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0211 0.0374
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0264 0.1786
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0044 0.0073
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1406 0.1403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0014 0.0136 0.0715
Entamoeba histolytica hypothetical protein 0.0011 0.0102 0.0742
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0534 0.0952
Brugia malayi Spectrin alpha chain 0.0007 0.0041 0.0038
Brugia malayi TAR-binding protein 0.0074 0.1073 0.107
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0211 0.1277
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Onchocerca volvulus Peroxidase homolog 0.0095 0.1406 0.1394
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.015 0.0263
Trichomonas vaginalis esterase, putative 0.0039 0.0534 0.3779
Schistosoma mansoni dishevelled 0.0009 0.006 0.0103
Brugia malayi SH2 domain containing protein 0.0008 0.0044 0.004
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0008 0.0044 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1377 1
Loa Loa (eye worm) STAT protein 0.0008 0.0044 0.004
Loa Loa (eye worm) RNA binding protein 0.0074 0.1073 0.107
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0549 0.098
Brugia malayi SRC-1 0.0076 0.1111 0.1108
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0102 0.0595
Brugia malayi hypothetical protein 0.0095 0.1406 0.1403
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0069 0.0995 0.1781
Brugia malayi Peripheral plasma membrane protein CASK 0.0007 0.0041 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0177 0.0174
Echinococcus granulosus signal transduction protein lnk realted 0.0008 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0211 0.0374
Schistosoma mansoni suppressor of cytokine signaling 0.0008 0.0044 0.0073
Echinococcus multilocularis tar DNA binding protein 0.0074 0.1073 0.192
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0008 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0038
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0603 0.4211
Schistosoma mansoni tyrosine kinase 0.0076 0.1111 0.1989
Echinococcus granulosus Protein son of sevenless 0.0006 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Entamoeba histolytica hypothetical protein 0.0006 0.0022 0.0156
Echinococcus multilocularis tensin 0.0008 0.0044 0.0073
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Onchocerca volvulus 0.0007 0.0041 0.0026
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0652 1
Echinococcus granulosus tyrosine protein kinase shark 0.001 0.0077 0.0132
Brugia malayi hypothetical protein 0.0014 0.015 0.0147
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0056 0.0799 0.5797
Entamoeba histolytica hypothetical protein 0.0035 0.0473 0.3433
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0159 0.028
Onchocerca volvulus 0.001 0.0077 0.0063
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.006 0.0103
Brugia malayi cytokine inducible SH2-containing protein 5 0.0008 0.0044 0.004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0401 0.0715
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0264 0.1668
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0382 0.2553
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0401 0.0398
Echinococcus granulosus smad 0.0008 0.0049 0.0082
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.006 0.0103
Echinococcus multilocularis nostrin 0.0007 0.0041 0.0067
Schistosoma mansoni run and tbc1 domain containing 0.0007 0.0041 0.0067
Leishmania major hypothetical protein, conserved 0.0022 0.0264 0.1896
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1111 0.1989
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0174
Onchocerca volvulus 0.0006 0.0022 0.0007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0041 0.0038
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0049 0.0082
Loa Loa (eye worm) hypothetical protein 0.0039 0.0534 0.0531
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Schistosoma mansoni tyrosine kinase 0.0017 0.0193 0.034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0549 0.3895
Brugia malayi RasGEF domain containing protein 0.0006 0.0022 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0401 0.0398
Brugia malayi N-terminal motif family protein 0.0006 0.0022 0.0018
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.006 0.0103
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0421 0.2951
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0049 0.0082
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0652 0.0649
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0651 0.4644
Echinococcus granulosus N chimaerin 0.0008 0.0044 0.0073
Brugia malayi Smad1 0.0008 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0147
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0193 0.0189
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.0022 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0603 0.1077
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0211 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1073 0.192
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0534 0.047
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.008 0.0429
Brugia malayi SH2 domain containing protein 0.001 0.0077 0.0074
Brugia malayi nuclear receptor NHR-88 0.0031 0.0401 0.0398
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0603 0.1077
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0382 0.5839
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0398
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.006 0.0103
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0401 0.0715
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0534 0.047
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0603 0.4293
Echinococcus granulosus hypothetical protein 0.0008 0.0044 0.0073
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0056 0.0799 0.5797
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0421 0.3045
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0014 0.0136 0.0239
Echinococcus multilocularis SH2 motif 0.0008 0.0044 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0074 0.0127
Onchocerca volvulus 0.0007 0.0041 0.0026
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1406 0.1403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0401 0.0398
Entamoeba histolytica unconventional myosin IB 0.0007 0.0041 0.0296
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0077 0.0074
Schistosoma mansoni d-amino acid oxidase 0.0163 0.2458 0.4406
Echinococcus multilocularis SH2 domain containing protein 7 0.0008 0.0044 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0534 0.3779
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0022 0.0033
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.001 0.0077 0.0132
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0007 0.0041 0.0067
Echinococcus granulosus tyrosine protein kinase Src42A 0.0067 0.0962 0.1721
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0007 0.0041 0.0067
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0549 0.3895
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0014 0.0136 0.0122
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0542 0.7871
Echinococcus granulosus tyrosine kinase 0.001 0.0077 0.0132
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0076 0.1111 0.1989
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Schistosoma mansoni nuclear receptor 0.0014 0.015 0.0263
Echinococcus granulosus expressed protein 0.0007 0.0041 0.0067
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.004
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Entamoeba histolytica hypothetical protein 0.0007 0.0041 0.0296
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0056 0.0799 0.574
Schistosoma mansoni dep domain containing protein 0.0009 0.006 0.0103
Mycobacterium leprae Probable lipase LipE 0.0039 0.0534 0.047
Echinococcus multilocularis Spectrin alpha actinin 0.0007 0.0041 0.0067
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0159 0.028
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0401 0.0715
Brugia malayi protein-tyrosine kinase 0.0069 0.0995 0.0993
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0401 0.0398
Schistosoma mansoni smad 0.0008 0.0049 0.0082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.3813 0.4347
Echinococcus multilocularis tyrosine kinase 0.001 0.0077 0.0132
Entamoeba histolytica hypothetical protein, conserved 0.0007 0.0041 0.0296
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0159 0.0156
Brugia malayi RE18450p 0.0014 0.0136 0.0133
Echinococcus multilocularis expressed protein 0.0007 0.0041 0.0067
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0211 0.0208
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0014 0.0136 0.099
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0177 0.0311
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0022 0.0033
Schistosoma mansoni inositol monophosphatase 0.004 0.0549 0.098
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0401 0.0715
Schistosoma mansoni smad1 5 8 and 0.0008 0.0049 0.0082
Trichomonas vaginalis hypothetical protein 0.0033 0.0441 0.3092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0401 0.0398
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0459
Leishmania major hypothetical protein, conserved 0.0007 0.0041 0.0273
Schistosoma mansoni signal transduction protein lnk-related 0.0008 0.0044 0.0073
Mycobacterium tuberculosis Conserved protein 0.0039 0.0534 0.047
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0022 0.0033
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0022 0.0156
Mycobacterium tuberculosis Conserved protein 0.0039 0.0534 0.047
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0022 0.0033
Schistosoma mansoni regulator of G protein signaling 0.0009 0.006 0.0103
Trypanosoma brucei polo-like protein kinase 0.0093 0.1377 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.006 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0401 0.0715
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0549 0.3991
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0159 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0041 0.0142
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0007 0.0041 0.0067
Brugia malayi hypothetical protein 0.001 0.0077 0.0074
Loa Loa (eye worm) TK protein kinase 0.0061 0.0877 0.0874
Brugia malayi Peroxidasin 0.0095 0.1408 0.1405
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0056 0.0799 0.574
Onchocerca volvulus 0.0039 0.0534 0.052
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0007 0.0041 0.0067
Schistosoma mansoni fad oxidoreductase 0.0014 0.0136 0.0239
Trypanosoma brucei beta lactamase 0.0062 0.0894 0.6391
Echinococcus multilocularis son of sevenless 1 0.0006 0.0022 0.0033
Toxoplasma gondii hypothetical protein 0.0014 0.0136 0.2052
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0401 0.0715
Loa Loa (eye worm) hypothetical protein 0.0095 0.1406 0.1403
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0211 0.3211
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.015 0.0135
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0044 0.004
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0007 0.0041 0.0142
Echinococcus granulosus SH2 motif 0.0008 0.0044 0.0073
Onchocerca volvulus 0.0008 0.0044 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1742 0.1739
Schistosoma mansoni Dab2-interacting protein-like 0.0007 0.0041 0.0067
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0534 0.047
Leishmania major hypothetical protein, conserved 0.0039 0.0534 0.3862
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0008 0.0044 0.0073
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0102 0.0595
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0159 0.028
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0067 0.0962 0.1721
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0007 0.0041 0.0067
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0022 0.0033
Onchocerca volvulus Peroxidase homolog 0.0095 0.1406 0.1394
Schistosoma mansoni nck2/grb4 0.0015 0.0159 0.028
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0007 0.0041 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1377 0.2465
Schistosoma mansoni tensin 0.0008 0.0044 0.0073
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0015 0.0105
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.006 0.0046
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0056 0.0799 0.574
Echinococcus granulosus tensin 0.0008 0.0044 0.0073
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0014 0.0136 0.0847
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0534 0.047

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 1 uM Inhibition of ovine COX2 ChEMBL. 18835505
IC50 (binding) > 10 uM Inhibition of ovine COX1 ChEMBL. 18835505
Inhibition (binding) = 42 % Inhibition of ovine COX1 at 10 uM ChEMBL. 18835505
Inhibition (binding) = 55 % Inhibition of ovine COX2 at 1 uM ChEMBL. 18835505
Inhibition (binding) = 56 % Inhibition of ovine COX2 at 10 uM ChEMBL. 18835505

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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