Detailed information for compound 989239

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.397 | Formula: C21H18FN5O4
  • H donors: 3 H acceptors: 4 LogP: 0.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c(=O)[nH]c2c1ccc(c2)F)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C
  • InChi: 1S/C21H18FN5O4/c1-26-19(30)25-18(29)21(26)8-11-2-4-14(6-12(11)9-21)23-17(28)10-27-16-5-3-13(22)7-15(16)24-20(27)31/h2-7H,8-10H2,1H3,(H,23,28)(H,24,31)(H,25,29,30)/t21-/m1/s1
  • InChiKey: QXTMTWFBFRSKBE-OAQYLSRUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcitonin receptor-like Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c calcitonin receptor-like 461 aa 434 aa 28.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0952 0.1683
Brugia malayi Pre-SET motif family protein 0.021 0.1963 0.3408
Schistosoma mansoni tubulin subunit beta 0.0576 0.5635 0.5626
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0034 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0945 0.1641
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0481 0.0462
Brugia malayi hypothetical protein 0.0082 0.0672 0.1167
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0952 0.0935
Echinococcus multilocularis Tubulin beta 2C chain 0.0576 0.5635 0.5626
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0249 0.0452
Trypanosoma brucei epsilon tubulin 0.0378 0.3641 0.6449
Loa Loa (eye worm) hypothetical protein 0.0036 0.0218 0.0378
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0117 0.0131
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0672 0.1167
Echinococcus granulosus ecdysone induced protein 78C 0.0149 0.1353 0.1336
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0086 0.0149
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0952 0.0935
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0444 0.4307 0.7641
Loa Loa (eye worm) nuclear receptor NHR-67 0.0068 0.0535 0.0928
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0332 0.0313
Loa Loa (eye worm) tubulin beta-2A chain 0.0576 0.5635 0.9783
Loa Loa (eye worm) tubulin alpha 2 0.028 0.2663 0.4623
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0218 0.0918
Echinococcus multilocularis tubulin gamma 1 chain 0.0378 0.3641 0.3628
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0636 0.1097
Brugia malayi nuclear hormone receptor 0.0068 0.0535 0.0928
Trichomonas vaginalis tubulin beta chain, putative 0.0444 0.4307 0.7641
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0378 0.3641 0.6449
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0108 0.094 0.6123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0054
Schistosoma mansoni tubulin subunit epsilon 0.0378 0.3641 0.3628
Plasmodium vivax tubulin beta chain, putative 0.0576 0.5635 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Mycobacterium tuberculosis Hypothetical protein 0.0052 0.0371 0.1626
Echinococcus granulosus thymidylate synthase 0.0108 0.094 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0249 0.0434
Loa Loa (eye worm) nuclear factor I 0.0022 0.0077 0.0133
Schistosoma mansoni tubulin subunit delta 0.0164 0.1498 0.1482
Plasmodium vivax delta tubulin, putative 0.0164 0.1498 0.2633
Onchocerca volvulus 0.0027 0.0127 0.0195
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0149 0.1353 0.1336
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0145 0.0125
Toxoplasma gondii endonuclease IV APN 0.0077 0.0629 0.1084
Trichomonas vaginalis tubulin alpha chain, putative 0.0214 0.1997 0.3538
Mycobacterium leprae Probable lipase LipE 0.0036 0.0218 0.1112
Leishmania major beta tubulin 0.0576 0.5635 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0161 0.0141
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0117 0.0174
Schistosoma mansoni nuclear hormone receptor 0.0149 0.1353 0.1336
Schistosoma mansoni thyroid hormone receptor 0.0276 0.2625 0.261
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0108 0.094 0.4263
Brugia malayi Cell division protein ftsZ 0.0164 0.1498 0.2601
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.1353 0.1336
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0078 0.0636 0.0617
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0218 0.0918
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0629 0.3963
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0044 0.0297 0.1874
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0044 0.0297 0.1284
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0764 0.0745
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0151 0.026
Echinococcus granulosus tumor protein p63 0.034 0.3268 0.3255
Trypanosoma brucei alpha tubulin 0.0444 0.4307 0.7635
Echinococcus multilocularis tubulin epsilon chain 0.0378 0.3641 0.3628
Echinococcus multilocularis tubulin subunit beta 0.0576 0.5635 0.5626
Trypanosoma cruzi epsilon tubulin, putative 0.0378 0.3641 0.6449
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0068 0.0535 0.0928
Echinococcus multilocularis Smad4 0.004 0.0256 0.0237
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0149 0.1353 0.1336
Trypanosoma brucei alpha tubulin 0.0444 0.4307 0.7635
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0636 0.0617
Leishmania major beta tubulin 0.0576 0.5635 1
Schistosoma mansoni Smad4 0.0018 0.0034 0.0014
Brugia malayi MH1 domain containing protein 0.004 0.0256 0.0445
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0634 0.1094
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0044 0.0044
Loa Loa (eye worm) alpha-tubulin isotype 2 0.028 0.2663 0.4623
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0629 0.1084
Chlamydia trachomatis endonuclease IV 0.0077 0.0629 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0133
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0117 0.0174
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0535 0.0516
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0218 0.1341
Echinococcus multilocularis lamin dm0 0.0027 0.0127 0.0107
Brugia malayi glutathione reductase 0.0048 0.0332 0.0576
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0952 0.1625
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1066 0.4845
Schistosoma mansoni lamin 0.0027 0.0127 0.0107
Onchocerca volvulus 0.0031 0.0163 0.0272
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0086 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0149 0.1353 0.2348
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0218 0.1112
Echinococcus granulosus neuropeptide receptor A26 0.047 0.4567 0.4556
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0133 0.0229
Loa Loa (eye worm) p25-alpha family protein 0.0369 0.3552 0.6166
Loa Loa (eye worm) hypothetical protein 0.0108 0.0939 0.1631
Loa Loa (eye worm) beta-tubulin 0.0576 0.5635 0.9783
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0944 0.4282
Schistosoma mansoni alpha tubulin 0.0444 0.4307 0.4296
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0211
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0151 0.026
Plasmodium vivax tubulin alpha chain, putative 0.0444 0.4307 0.7635
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0149 0.1353 0.2348
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0355 0.0598
Brugia malayi Tubulin alpha chain 0.0444 0.4307 0.7477
Echinococcus granulosus tubulin alpha 3 chain 0.0444 0.4307 0.4296
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0164 0.1498 0.2633
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0151 0.2154
Trypanosoma brucei tubulin gamma chain 0.0378 0.3641 0.6449
Mycobacterium ulcerans cell division protein FtsZ 0.0164 0.1498 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0117 0.0174
Onchocerca volvulus TPPP family protein homolog 0.0369 0.3552 0.7397
Schistosoma mansoni smad 0.0018 0.0034 0.0014
Loa Loa (eye worm) hypothetical protein 0.0077 0.0629 0.1091
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0634 0.1055
Brugia malayi hypothetical protein 0.0215 0.2008 0.3486
Leishmania major beta tubulin 0.0576 0.5635 1
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0218 0.1341
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0332 0.0556
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0151 0.026
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0952 0.1653
Brugia malayi hypothetical protein 0.0052 0.0371 0.0643
Brugia malayi 6-phosphofructokinase 0.011 0.0952 0.1653
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0576 0.5635 0.5626
Brugia malayi isocitrate dehydrogenase 0.0078 0.0636 0.1103
Plasmodium vivax tubulin epsilon chain, putative 0.0378 0.3641 0.6449
Trichomonas vaginalis tubulin alpha chain, putative 0.0214 0.1997 0.3538
Echinococcus granulosus lamin dm0 0.0027 0.0127 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0636 0.0617
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0218 0.0378
Brugia malayi dihydrofolate reductase family protein 0.0044 0.0297 0.0515
Brugia malayi hypothetical protein 0.0032 0.0178 0.0308
Trichomonas vaginalis tubulin beta chain, putative 0.0444 0.4307 0.7641
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0764 0.1326
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0636 0.1097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.1353 0.1336
Loa Loa (eye worm) thymidylate synthase 0.0108 0.094 0.1631
Echinococcus multilocularis CREB binding protein 0.0017 0.0022 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0149 0.1353 0.2348
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0044 0.0297 0.1659
Schistosoma mansoni steroid hormone receptor ad4bp 0.0149 0.1353 0.1336
Loa Loa (eye worm) hypothetical protein 0.023 0.2164 0.3757
Schistosoma mansoni cpg binding protein 0.0031 0.0161 0.0141
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.023 0.2164 0.3836
Loa Loa (eye worm) tubulin beta-1 chain 0.0576 0.5635 0.9783
Toxoplasma gondii beta-1 tubulin, putative 0.0576 0.5635 1
Brugia malayi intermediate filament protein 0.0027 0.0127 0.022
Brugia malayi Smad1 0.004 0.0256 0.0445
Toxoplasma gondii beta-tubulin, putative 0.0576 0.5635 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Schistosoma mansoni hypothetical protein 0.0106 0.0915 0.0897
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0151 0.0234
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0082 0.0672 0.0654
Trichomonas vaginalis tubulin beta chain, putative 0.0444 0.4307 0.7641
Loa Loa (eye worm) hypothetical protein 0.0031 0.0162 0.0281
Plasmodium vivax tubulin alpha chain, putative 0.0444 0.4307 0.7635
Mycobacterium ulcerans hypothetical protein 0.0036 0.0218 0.1341
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.1179
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0218 0.0918
Onchocerca volvulus 0.0068 0.0535 0.1053
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0086 0.0118
Loa Loa (eye worm) hypothetical protein 0.005 0.0354 0.0614
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0355 0.0598
Brugia malayi Steroid receptor seven-up type 2 0.0149 0.1353 0.2348
Brugia malayi tailless protein 0.0068 0.0535 0.0928
Brugia malayi nuclear receptor RXR 0.0068 0.0535 0.0928
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0044 0.007
Brugia malayi Flap endonuclease-1 0.0026 0.0117 0.0203
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0722 0.1252
Plasmodium vivax glutathione reductase, putative 0.0048 0.0332 0.0556
Echinococcus granulosus chromobox protein 1 0.007 0.0558 0.0539
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0952 0.1625
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0279 0.0487
Leishmania major beta tubulin 0.0576 0.5635 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0044 0.0076
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0117 0.0098
Echinococcus granulosus intermediate filament protein 0.0027 0.0127 0.0107
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0722 0.1275
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0068 0.0535 0.0516
Treponema pallidum cell division protein FtsZ 0.0164 0.1498 1
Schistosoma mansoni retinoic acid receptor RXR 0.0249 0.2349 0.2334
Onchocerca volvulus 0.0108 0.094 0.1905
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0952 0.1661
Onchocerca volvulus 0.0027 0.0127 0.0195
Brugia malayi nuclear hormone receptor 0.0149 0.1353 0.2348
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0944 0.6152
Brugia malayi bZIP transcription factor family protein 0.0085 0.0703 0.122
Echinococcus granulosus tubulin alpha 3 chain 0.0444 0.4307 0.4296
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0044 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0199 0.018
Echinococcus granulosus Tubulin beta 2C chain 0.0576 0.5635 0.5626
Schistosoma mansoni tubulin subunit alpha 0.0164 0.1498 0.1482
Onchocerca volvulus 0.005 0.0354 0.0673
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0218 0.0199
Echinococcus granulosus nuclear receptor nhr 48 0.0068 0.0535 0.0516
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0952 0.0935
Trypanosoma cruzi epsilon tubulin, putative 0.0378 0.3641 0.6449
Trichomonas vaginalis tubulin gamma chain, putative 0.0576 0.5635 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0576 0.5635 0.5626
Toxoplasma gondii exonuclease III APE 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0284
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0535 0.1053
Echinococcus multilocularis smad 0.004 0.0256 0.0237
Loa Loa (eye worm) alpha-tubulin 0.0444 0.4307 0.7477
Echinococcus multilocularis chromobox protein 1 0.007 0.0558 0.0539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0149 0.1353 0.2348
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0149 0.1353 0.1336
Leishmania major beta tubulin 0.0576 0.5635 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0149 0.1353 0.2348
Brugia malayi Pax transcription factor protein 2 0.0492 0.479 0.8315
Schistosoma mansoni smad1 5 8 and 0.004 0.0256 0.0237
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0164 0.1498 0.2633
Brugia malayi beta-lactamase family protein 0.0036 0.0218 0.0378
Loa Loa (eye worm) hypothetical protein 0.0444 0.4307 0.7477
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0044 0.0025
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Mycobacterium ulcerans hypothetical protein 0.002 0.0058 0.0258
Loa Loa (eye worm) BEN-1 protein 0.0576 0.5635 0.9783
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.1382 0.2427
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0086 0.0149
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0058 0.0177
Leishmania major gamma-tubulin 0.0378 0.3641 0.6449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0764 0.0745
Entamoeba histolytica tubulin gamma chain 0.0378 0.3641 0.6433
Echinococcus multilocularis Tubulin alpha 1 chain 0.0444 0.4307 0.4296
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0151 0.026
Brugia malayi Isocitrate dehydrogenase 0.0078 0.0636 0.1103
Echinococcus multilocularis Tubulin alpha 1 chain 0.0444 0.4307 0.4296
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0044 0.0044
Schistosoma mansoni tubulin subunit alpha 0.0444 0.4307 0.4296
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0952 0.1683
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0117 0.02
Trichomonas vaginalis tubulin, putative 0.0576 0.5635 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0629 0.1091
Brugia malayi follicle stimulating hormone receptor 0.0238 0.2242 0.3893
Trypanosoma brucei beta tubulin 0.0576 0.5635 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0444 0.4307 0.4296
Trypanosoma brucei tubulin delta chain 0.0164 0.1498 0.2633
Brugia malayi hypothetical protein 0.0066 0.052 0.0903
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Echinococcus multilocularis tubulin alpha chain 0.0444 0.4307 0.4296
Toxoplasma gondii alpha-tubulin I, putative 0.0444 0.4307 0.7635
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0078 0.0636 0.1097
Schistosoma mansoni intermediate filament proteins 0.0027 0.0127 0.0107
Onchocerca volvulus 0.0036 0.0218 0.0387
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0952 0.1661
Leishmania major hypothetical protein, conserved 0.005 0.0355 0.0598
Echinococcus multilocularis tubulin alpha chain 0.0444 0.4307 0.4296
Schistosoma mansoni nuclear receptor 0.0068 0.0535 0.0516
Trichomonas vaginalis tubulin alpha chain, putative 0.0576 0.5635 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0629 0.1084
Trypanosoma cruzi tubulin delta chain 0.0164 0.1498 0.2633
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0127 0.022
Trichomonas vaginalis tubulin gamma chain, putative 0.0378 0.3641 0.6458
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0078 0.0636 0.0617
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0127 0.022
Echinococcus multilocularis CREB binding protein 0.0017 0.0022 0.0002
Loa Loa (eye worm) tubulin alpha chain 0.0444 0.4307 0.7477
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0127 0.022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0945 0.1641
Leishmania major cytochrome p450-like protein 0.0023 0.0086 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0218 0.0353
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0952 0.0935
Brugia malayi tubulin alpha-2 chain 0.0444 0.4307 0.7477
Leishmania major beta tubulin 0.0576 0.5635 1
Giardia lamblia Beta tubulin 0.0576 0.5635 1
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Trichomonas vaginalis tubulin epsilon chain, putative 0.0576 0.5635 1
Echinococcus multilocularis geminin 0.1012 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0722 0.1252
Brugia malayi Nuclear hormone receptor-like 1 0.0149 0.1353 0.2348
Echinococcus granulosus tubulin alpha 1C chain 0.0444 0.4307 0.4296
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1126 0.1109
Echinococcus multilocularis ecdysone induced protein 78C 0.0149 0.1353 0.1336
Brugia malayi p25-alpha family protein 0.0369 0.3552 0.6166
Leishmania major beta tubulin 0.0576 0.5635 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0199 0.018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0199 0.0346
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Schistosoma mansoni coup transcription factor 0.0149 0.1353 0.1336
Mycobacterium ulcerans epimerase 0.002 0.0058 0.0258
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0058 0.0258
Trypanosoma cruzi zeta tubulin, putative 0.0164 0.1498 0.2633
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0218 0.0379
Entamoeba histolytica hypothetical protein 0.0215 0.2008 0.3513
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0079 0.0059
Mycobacterium ulcerans thymidylate synthase 0.0108 0.094 0.6223
Leishmania major beta tubulin 0.0576 0.5635 1
Echinococcus multilocularis GPCR, family 2 0.0034 0.0199 0.018
Leishmania major beta tubulin 0.0576 0.5635 1
Onchocerca volvulus 0.0042 0.0277 0.0512
Echinococcus multilocularis beta tubulin 0.0576 0.5635 0.5626
Trypanosoma cruzi tubulin gamma chain 0.0378 0.3641 0.6449
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Echinococcus granulosus Tubulin beta 2C chain 0.0576 0.5635 0.5626
Schistosoma mansoni RAR-like nuclear receptor 0.0149 0.1353 0.1336
Trypanosoma brucei alpha tubulin 0.0444 0.4307 0.7635
Brugia malayi ecdysone receptor 0.0068 0.0535 0.0928
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0149 0.1353 0.2348
Schistosoma mansoni hypothetical protein 0.1012 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0068 0.0535 0.0516
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0117 0.0174
Trypanosoma brucei epsilon tubulin 0.0378 0.3641 0.6449
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0086 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0371 0.065
Schistosoma mansoni CREB-binding protein 2 0.0109 0.0949 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0149 0.1353 0.2348
Plasmodium falciparum thioredoxin reductase 0.0048 0.0332 0.0556
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Trichomonas vaginalis tubulin epsilon chain, putative 0.0444 0.4307 0.7641
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1126 0.1109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0249 0.2349 0.2334
Echinococcus multilocularis tubulin alpha 1C chain 0.0444 0.4307 0.4296
Echinococcus granulosus Tubulin beta 2C chain 0.0576 0.5635 0.5626
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0044 0.0044
Brugia malayi MH2 domain containing protein 0.004 0.0256 0.0445
Loa Loa (eye worm) hypothetical protein 0.0164 0.1503 0.261
Plasmodium falciparum tubulin delta chain, putative 0.0164 0.1498 0.2633
Brugia malayi chromobox protein homolog 3 0.0039 0.0249 0.0432
Plasmodium falciparum tubulin gamma chain 0.0378 0.3641 0.6449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0149 0.1353 0.2348
Loa Loa (eye worm) tubulin alpha-2 chain 0.0444 0.4307 0.7477
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0109 0.0949 0.0931
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0082 0.0672 0.1167
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0558 0.0969
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0218 0.0199
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0044 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0149 0.1353 0.1336
Leishmania major beta tubulin 0.0576 0.5635 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0444 0.4307 0.4296
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0636 0.1097
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.002 0.0027
Echinococcus multilocularis tubulin alpha chain 0.0444 0.4307 0.4296
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0634 0.1094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0764 0.0745
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0535 0.0516
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0636 0.1097
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0535 0.0516
Loa Loa (eye worm) hypothetical protein 0.0034 0.0199 0.0346
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0044 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0149 0.1353 0.2348
Trichomonas vaginalis tubulin, putative 0.0214 0.1997 0.3538
Schistosoma mansoni chromobox protein 0.007 0.0558 0.0539
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0703 0.0684
Schistosoma mansoni tubulin subunit alpha 0.0444 0.4307 0.4296
Brugia malayi nuclear receptor NHR-67 0.0068 0.0535 0.0928
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0044 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0044 0.0165
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0218 0.0918
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0218 0.0199
Echinococcus granulosus GPCR family 2 0.0034 0.0199 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0218 0.0378
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0078 0.0636 0.0617
Brugia malayi beta-lactamase family protein 0.0036 0.0218 0.0378
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0332 0.1446
Echinococcus granulosus chromobox protein 1 0.007 0.0558 0.0539
Brugia malayi MH1 domain containing protein 0.0022 0.0077 0.0133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0162 0.0143
Leishmania major beta tubulin 0.0576 0.5635 1
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0256 0.0445
Echinococcus granulosus beta tubulin 0.0576 0.5635 0.5626
Echinococcus granulosus peroxisome assembly protein 26 0.0444 0.4307 0.4296
Chlamydia trachomatis dihydrofolate reductase 0.0044 0.0297 0.4552
Loa Loa (eye worm) hypothetical protein 0.0036 0.0218 0.0378
Trypanosoma brucei beta tubulin 0.0378 0.3641 0.6449
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0151 0.026
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0952 0.4321
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0149 0.1353 0.1336
Echinococcus granulosus lamin 0.0027 0.0127 0.0107
Schistosoma mansoni hypothetical protein 0.1012 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0078 0.0636 0.0617
Brugia malayi Tubulin gamma chain 0.0378 0.3641 0.6321
Echinococcus multilocularis tubulin beta 1 chain 0.0576 0.5635 0.5626
Schistosoma mansoni lamin 0.0027 0.0127 0.0107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0215 0.2008 0.1992
Loa Loa (eye worm) hypothetical protein 0.0036 0.0218 0.0378
Loa Loa (eye worm) hypothetical protein 0.0048 0.0335 0.0581
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0149 0.1353 0.1336
Echinococcus granulosus dihydrofolate reductase 0.0044 0.0297 0.0278
Trypanosoma brucei alpha tubulin, putative 0.0214 0.1997 0.3521
Echinococcus multilocularis jun protein 0.0085 0.0703 0.0684
Toxoplasma gondii ABC1 family protein 0.0036 0.0218 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.1353 0.1336
Loa Loa (eye worm) alpha-tubulin 0.0444 0.4307 0.7477
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0722 0.1275
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0636 0.0617
Schistosoma mansoni alpha tubulin 0.0444 0.4307 0.4296
Schistosoma mansoni flap endonuclease-1 0.0024 0.0092 0.0072
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0355 0.0598
Schistosoma mansoni hypothetical protein 0.0034 0.0199 0.018
Schistosoma mansoni tubulin subunit beta 0.0164 0.1498 0.1482
Brugia malayi ecdysteroid receptor 0.0149 0.1353 0.2348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0149 0.1353 0.2348
Echinococcus multilocularis tubulin alpha 3 chain 0.0444 0.4307 0.4296
Echinococcus multilocularis thyroid hormone receptor alpha 0.0276 0.2625 0.261
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0151 0.0234
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.1382 0.2427
Loa Loa (eye worm) hypothetical protein 0.0082 0.0672 0.1167
Echinococcus granulosus tubulin alpha chain 0.0444 0.4307 0.4296
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0218 0.0353
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0535 0.0928
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0636 0.1097
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0355 0.0598
Trypanosoma brucei alpha tubulin 0.0444 0.4307 0.7635
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0952 0.1683
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0432
Onchocerca volvulus 0.0066 0.052 0.1023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.0054
Schistosoma mansoni hypothetical protein 0.0034 0.0199 0.018
Trichomonas vaginalis tubulin alpha chain, putative 0.0214 0.1997 0.3538
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0164 0.1498 0.2653
Brugia malayi nuclear receptor NHR-88 0.0068 0.0535 0.0928
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0152 0.1382 0.2427
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0722 0.0704
Loa Loa (eye worm) hypothetical protein 0.0036 0.0218 0.0378
Trichomonas vaginalis tubulin beta chain, putative 0.0576 0.5635 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.1353 0.1336
Loa Loa (eye worm) tubulin alpha chain 0.0444 0.4307 0.7477
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0151 0.026
Loa Loa (eye worm) hypothetical protein 0.0082 0.0672 0.1167
Schistosoma mansoni hypothetical protein 0.0074 0.06 0.0582
Trypanosoma cruzi alpha tubulin, putative 0.0444 0.4307 0.7635
Entamoeba histolytica tubulin alpha-1 chain 0.0444 0.4307 0.7625
Schistosoma mansoni TGF-beta signal transducer Smad2 0.004 0.0256 0.0237
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0149 0.1353 0.1336
Trichomonas vaginalis tubulin epsilon chain, putative 0.0444 0.4307 0.7641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0149 0.1353 0.2348
Plasmodium falciparum glutathione reductase 0.0048 0.0332 0.0556
Onchocerca volvulus 0.0036 0.0218 0.0387
Toxoplasma gondii beta tubulin 0.0576 0.5635 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0149 0.1353 0.2348
Schistosoma mansoni zinc finger protein 0.0068 0.0535 0.0516
Echinococcus granulosus Smad4 0.004 0.0256 0.0237
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0052 0.0371 0.0625
Trypanosoma brucei trypanothione reductase 0.0048 0.0332 0.0556
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0218 0.0379
Plasmodium falciparum tubulin epsilon chain, putative 0.0378 0.3641 0.6449
Echinococcus multilocularis Tubulin beta 2C chain 0.0576 0.5635 0.5626
Onchocerca volvulus 0.0029 0.0144 0.0232
Brugia malayi thymidylate synthase 0.0108 0.094 0.1631
Brugia malayi nuclear hormone receptor family member nhr-6 0.0068 0.0535 0.0928
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0218 0.0379
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.0672 0.0654
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0152 0.1382 0.2427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0149 0.1353 0.2348
Brugia malayi Tubulin alpha-2 chain 0.0444 0.4307 0.7477
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2254 0.3995
Echinococcus granulosus tubulin alpha chain 0.0444 0.4307 0.4296
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0952 0.1625
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0214 0.1997 0.3538
Echinococcus multilocularis tubulin alpha 0.0378 0.3641 0.3628
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0117 0.0203
Brugia malayi steroid hormone receptor 0.0149 0.1353 0.2348
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0082 0.0672 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0218 0.0353
Mycobacterium tuberculosis Probable reductase 0.0109 0.0944 0.4282
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0952 0.6211
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.06 0.1042
Echinococcus granulosus beta tubulin 0.0576 0.5635 0.5626
Brugia malayi Tubulin beta chain 0.0164 0.1498 0.2601
Leishmania major delta tubulin, putative 0.0164 0.1498 0.2633
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0151 0.0234
Leishmania major beta tubulin 0.0576 0.5635 1
Trypanosoma brucei beta tubulin 0.0576 0.5635 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0535 0.0516
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.029 0.2764 0.275
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0952 0.1683
Entamoeba histolytica hypothetical protein 0.0215 0.2008 0.3513
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0108 0.094 0.0922
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1363 0.1346
Brugia malayi hypothetical protein 0.005 0.0355 0.0617
Leishmania major epsilon tubulin, putative 0.0378 0.3641 0.6449
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0034 0.0059
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0025
Brugia malayi hypothetical protein 0.0068 0.0535 0.0928
Schistosoma mansoni chromobox protein 0.007 0.0558 0.0539
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0149 0.1353 0.1336
Loa Loa (eye worm) tubulin gamma chain 0.0378 0.3641 0.6321
Schistosoma mansoni hypothetical protein 0.0127 0.1126 0.1109
Onchocerca volvulus 0.0037 0.0223 0.0398
Brugia malayi hypothetical protein 0.0082 0.0672 0.1167
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Mycobacterium ulcerans beta-lactamase 0.0036 0.0218 0.1341
Schistosoma mansoni thyroid hormone receptor 0.0276 0.2625 0.261
Plasmodium falciparum flap endonuclease 1 0.0026 0.0117 0.0174
Echinococcus multilocularis TGF beta signal transducer SmadC 0.004 0.0256 0.0237
Schistosoma mansoni nuclear receptor 0.0068 0.0535 0.0516
Brugia malayi hypothetical protein 0.0164 0.1503 0.261
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0944 0.4282
Schistosoma mansoni alpha tubulin 0.0444 0.4307 0.4296
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0078 0.0636 0.1097
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0149 0.1353 0.2773
Brugia malayi PAS domain containing protein 0.0049 0.0346 0.06
Brugia malayi nuclear receptor RXR 0.0082 0.0672 0.1167
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0218 0.0918
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0764 0.0745
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.0297 0.0278
Onchocerca volvulus 0.0036 0.0218 0.0387
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0149 0.1353 0.1336
Brugia malayi beta-lactamase 0.0036 0.0218 0.0378
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1066 0.4845
Trichomonas vaginalis chromobox protein, putative 0.007 0.0558 0.0983
Loa Loa (eye worm) tubulin beta-4 chain 0.0576 0.5635 0.9783
Schistosoma mansoni cpg binding protein 0.0031 0.0161 0.0141
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0152 0.1382 0.2427
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0817 0.8048 0.8044
Brugia malayi MH2 domain containing protein 0.0018 0.0034 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0672 0.1167
Echinococcus granulosus jun protein 0.0085 0.0703 0.0684
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0218 0.0379
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0332 0.0576
Echinococcus multilocularis Tubulin beta 2C chain 0.0576 0.5635 0.5626
Echinococcus granulosus alpha tubulin 0.0444 0.4307 0.4296
Trichomonas vaginalis tubulin beta chain, putative 0.0444 0.4307 0.7641
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0149 0.1353 0.2348
Brugia malayi Muscleblind-like protein 0.0151 0.1363 0.2367
Echinococcus granulosus cpg binding protein 0.0031 0.0161 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0149 0.1353 0.2348
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0162 0.0254
Echinococcus multilocularis Tubulin beta 2C chain 0.0576 0.5635 0.5626
Echinococcus granulosus tubulin subunit TubB 0.0444 0.4307 0.4296
Brugia malayi TAZ zinc finger family protein 0.0109 0.0949 0.1648
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0629 0.2821
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0722 0.1252
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0162 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0127 0.022
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0256 0.0445
Toxoplasma gondii thioredoxin reductase 0.0048 0.0332 0.0556
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0383 0.0664
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0054
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0952 0.6308
Echinococcus multilocularis Tubulin alpha 1 chain 0.0444 0.4307 0.4296
Entamoeba histolytica tubulin family protein 0.0576 0.5635 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0162 0.0143
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1963 0.3408
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0117 0.0174
Brugia malayi Tubulin beta chain 0.0214 0.1997 0.3466
Leishmania major beta tubulin 0.0576 0.5635 1
Brugia malayi MH1 domain containing protein 0.004 0.0256 0.0445
Brugia malayi Cytochrome P450 family protein 0.0023 0.0086 0.0149
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0149 0.1353 0.1336
Brugia malayi alpha-tubulin 0.0444 0.4307 0.7477
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0108 0.0939 0.1631
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0068 0.0535 0.0928
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0044 0.0113
Onchocerca volvulus 0.0239 0.2254 0.4668
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0034 0.0014
Echinococcus granulosus single minded 2 0.0036 0.0218 0.0199
Loa Loa (eye worm) hypothetical protein 0.005 0.0355 0.0617
Echinococcus granulosus tubulin beta 4A class IVa 0.0576 0.5635 0.5626
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0151 0.0191
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Echinococcus granulosus transcription factor eb 0.0109 0.0945 0.0927
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0086 0.0118
Echinococcus granulosus tubulin alpha chain 0.0444 0.4307 0.4296
Loa Loa (eye worm) hypothetical protein 0.028 0.2663 0.4623
Echinococcus granulosus Tubulin beta 2C chain 0.0576 0.5635 0.5626
Mycobacterium tuberculosis Conserved protein 0.0036 0.0218 0.0918
Brugia malayi MH2 domain containing protein 0.0589 0.576 1
Trypanosoma brucei beta tubulin 0.0576 0.5635 1
Loa Loa (eye worm) transcription factor SMAD2 0.0589 0.576 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0355 0.0598
Schistosoma mansoni hypothetical protein 0.0022 0.0079 0.0059
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0535 0.1053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0944 0.4282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0059
Trichomonas vaginalis esterase, putative 0.0036 0.0218 0.0379
Brugia malayi acetyltransferase, GNAT family protein 0.029 0.2764 0.4798
Schistosoma mansoni tubulin subunit beta 0.0576 0.5635 0.5626
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0078 0.0636 0.1097
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Giardia lamblia Beta tubulin 0.0576 0.5635 1
Loa Loa (eye worm) BEN-1 protein 0.0576 0.5635 0.9783
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0535 0.0516
Onchocerca volvulus Protein ultraspiracle homolog 0.0149 0.1353 0.2773
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.029 0.2764 0.275
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0151 0.0234
Brugia malayi nuclear hormone receptor family member odr-7 0.0068 0.0535 0.0928
Giardia lamblia Gamma tubulin 0.0378 0.3641 0.6449
Trichomonas vaginalis tubulin gamma chain, putative 0.0164 0.1498 0.2653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0149 0.1353 0.2348
Loa Loa (eye worm) hypothetical protein 0.0082 0.0672 0.1167
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0117 0.0174
Giardia lamblia Alpha-tubulin 0.0444 0.4307 0.7635
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0218 0.0918
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0952 0.6308
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0149 0.1353 0.1336
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0218 0.0353
Echinococcus granulosus Tubulin beta 2C chain 0.0576 0.5635 0.5626
Loa Loa (eye worm) tubulin beta chain 0.0576 0.5635 0.9783
Trypanosoma brucei zeta tubulin, putative 0.0164 0.1498 0.2633
Brugia malayi Dihydrofolate reductase 0.0044 0.0297 0.0515
Echinococcus multilocularis neuropeptide receptor A26 0.047 0.4567 0.4556
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0764 0.0745
Echinococcus granulosus histone acetyltransferase KAT2B 0.028 0.2665 0.2651
Mycobacterium leprae cell division protein FtsZ 0.0164 0.1498 1
Schistosoma mansoni Smad4 0.0018 0.0034 0.0014
Leishmania major zeta tubulin, putative 0.0164 0.1498 0.2633
Schistosoma mansoni hypothetical protein 0.0215 0.2008 0.1992
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0218 0.1341
Onchocerca volvulus 0.0492 0.479 1
Echinococcus granulosus CREB binding protein 0.007 0.0557 0.0538
Brugia malayi Tubulin alpha chain 0.0164 0.1498 0.2601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0764 0.0745
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0151 0.026
Entamoeba histolytica tubulin alpha chain, putative 0.0444 0.4307 0.7625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0162 0.0143
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0078 0.0636 0.2854
Loa Loa (eye worm) hypothetical protein 0.0082 0.0672 0.1167
Plasmodium falciparum tubulin beta chain 0.0576 0.5635 1
Loa Loa (eye worm) tubulin alpha 2 0.028 0.2663 0.4623
Echinococcus multilocularis beta tubulin 0.0576 0.5635 0.5626
Leishmania major trypanothione reductase 0.0048 0.0332 0.0556
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0199 0.0346
Echinococcus granulosus tubulin epsilon chain 0.0378 0.3641 0.3628
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0944 0.4282
Schistosoma mansoni hypothetical protein 0.0034 0.0199 0.018
Schistosoma mansoni dihydrofolate reductase 0.0044 0.0297 0.0278
Trichomonas vaginalis tubulin, putative 0.0214 0.1997 0.3538
Echinococcus multilocularis lamin 0.0027 0.0127 0.0107
Schistosoma mansoni smad 0.004 0.0256 0.0237
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0079 0.0059
Brugia malayi Cytochrome P450 family protein 0.0023 0.0086 0.0149
Trichomonas vaginalis tubulin beta chain, putative 0.0444 0.4307 0.7641
Echinococcus multilocularis tubulin alpha chain 0.0444 0.4307 0.4296
Loa Loa (eye worm) hypothetical protein 0.0074 0.06 0.1042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0044 0.0044
Loa Loa (eye worm) acetyltransferase 0.029 0.2764 0.4798
Echinococcus granulosus flap endonuclease 1 0.0026 0.0117 0.0098
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0025
Brugia malayi Cytochrome P450 family protein 0.0053 0.0383 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0149 0.1353 0.2348
Echinococcus multilocularis musashi 0.0027 0.0127 0.0107
Schistosoma mansoni tubulin subunit alpha 0.0444 0.4307 0.4296
Entamoeba histolytica hypothetical protein 0.0215 0.2008 0.3513
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0332 0.0313
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0109 0.0945 0.164
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.002 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0034 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0149 0.1353 0.2348
Echinococcus multilocularis CREB binding protein 0.0017 0.0022 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0354 0.0335
Echinococcus multilocularis tubulin alpha 3 chain 0.0444 0.4307 0.4296
Echinococcus multilocularis hypothetical protein 0.0444 0.4307 0.4296
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0144 0.025
Mycobacterium ulcerans endonuclease IV 0.0077 0.0629 0.4118
Schistosoma mansoni single-minded 0.0049 0.0346 0.0327
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0149 0.1353 0.1336
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0082 0.0672 0.0654
Echinococcus granulosus tubulin subunit beta 0.0576 0.5635 0.5626
Trichomonas vaginalis tubulin gamma chain, putative 0.0378 0.3641 0.6458
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0944 0.4282
Loa Loa (eye worm) nuclear hormone receptor 0.0068 0.0535 0.0928
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Brugia malayi Pre-SET motif family protein 0.0031 0.0162 0.0281
Schistosoma mansoni transcription factor LCR-F1 0.0215 0.2008 0.1992
Onchocerca volvulus 0.0068 0.0535 0.1053
Brugia malayi hypoxia-induced factor 1 0.0152 0.1375 0.2388
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0068 0.0535 0.0516
Echinococcus multilocularis tubulin delta chain 0.0164 0.1498 0.1482
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0151 0.2154
Echinococcus granulosus tubulin alpha 0.0378 0.3641 0.3628
Onchocerca volvulus 0.0214 0.1997 0.4127
Schistosoma mansoni hypothetical protein 0.0069 0.0544 0.0525
Loa Loa (eye worm) hypothetical protein 0.0109 0.0945 0.1641
Plasmodium vivax tubulin gamma chain, putative 0.0378 0.3641 0.6449
Schistosoma mansoni tubulin subunit gamma 0.0378 0.3641 0.3628
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0151 0.0887
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0162 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0054
Echinococcus multilocularis tubulin alpha chain 0.0444 0.4307 0.4296
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0086 0.0149
Brugia malayi phosphofructokinase 0.011 0.0952 0.1653
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0149 0.1353 0.1336
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0215 0.2008 0.1992
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Trichomonas vaginalis tubulin beta chain, putative 0.0444 0.4307 0.7641
Echinococcus granulosus neuropeptide s receptor 0.047 0.4567 0.4556
Loa Loa (eye worm) pax transcription factor protein 2 0.0492 0.479 0.8315
Schistosoma mansoni hypothetical protein 0.0034 0.0199 0.018
Toxoplasma gondii alpha tubulin TUBA1 0.0444 0.4307 0.7635
Echinococcus granulosus tubulin alpha 1C chain 0.0444 0.4307 0.4296
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0151 0.0234
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0058 0.01
Trichomonas vaginalis tubulin, putative 0.0164 0.1498 0.2653
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0199 0.0346
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Loa Loa (eye worm) MH2 domain-containing protein 0.0589 0.576 1
Leishmania major alpha tubulin 0.0444 0.4307 0.7635
Trichomonas vaginalis tubulin beta chain, putative 0.0214 0.1997 0.3538
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0125
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.0297 0.0515
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0044 0.0044
Trypanosoma brucei zeta tubulin 0.0164 0.1498 0.2633
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0355 0.0598
Echinococcus granulosus thyroid hormone receptor alpha 0.0068 0.0535 0.0516
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0218 0.0199
Brugia malayi 6-phosphofructokinase 0.011 0.0952 0.1653
Echinococcus granulosus smad 0.004 0.0256 0.0237
Echinococcus granulosus tubulin beta 1 chain 0.0576 0.5635 0.5626
Loa Loa (eye worm) phosphofructokinase 0.011 0.0952 0.1653
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0355 0.0598
Brugia malayi conserved hypotetical protein 0.0068 0.0535 0.0928
Giardia lamblia Beta tubulin 0.0576 0.5635 1
Trypanosoma brucei epsilon tubulin 0.0378 0.3641 0.6449
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0535 0.0516
Echinococcus granulosus tubulin alpha chain 0.0444 0.4307 0.4296
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.0054
Plasmodium falciparum alpha tubulin 2 0.0444 0.4307 0.7635
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0351 0.0332
Plasmodium vivax SET domain protein, putative 0.0031 0.0162 0.0254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0199 0.018
Echinococcus granulosus CREB binding protein 0.0109 0.0949 0.0931
Echinococcus granulosus TGF beta signal transducer SmadC 0.004 0.0256 0.0237
Schistosoma mansoni smad1 5 8 and 0.004 0.0256 0.0237
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0078 0.0636 0.1097
Trichomonas vaginalis tubulin epsilon chain, putative 0.0576 0.5635 1
Echinococcus granulosus tubulin gamma 1 chain 0.0378 0.3641 0.3628
Loa Loa (eye worm) Smad1 0.004 0.0256 0.0445
Brugia malayi MH1 domain containing protein 0.0022 0.0077 0.0133
Onchocerca volvulus 0.0149 0.1353 0.2773
Echinococcus granulosus CREB binding protein 0.0017 0.0022 0.0002
Schistosoma mansoni Smad4 0.004 0.0256 0.0237
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0218 0.0918
Leishmania major beta tubulin 0.0576 0.5635 1
Entamoeba histolytica tubulin family protein 0.0576 0.5635 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0034 0.0059
Echinococcus granulosus FTZ F1 alpha 0.0149 0.1353 0.1336
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0149 0.1353 0.1336
Trichomonas vaginalis chromobox protein, putative 0.007 0.0558 0.0983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0054
Echinococcus multilocularis chromobox protein 1 0.007 0.0558 0.0539
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Brugia malayi tubulin alpha chain - mouse 0.0444 0.4307 0.7477
Brugia malayi Tubulin beta-1 chain 0.0576 0.5635 0.9783
Loa Loa (eye worm) hypothetical protein 0.0151 0.1363 0.2367
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0151 0.0234
Echinococcus multilocularis nuclear receptor nhr 48 0.0068 0.0535 0.0516
Echinococcus multilocularis tumor protein p63 0.034 0.3268 0.3255
Loa Loa (eye worm) DR-78 0.0068 0.0535 0.0928
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0952 0.1653
Brugia malayi Thioredoxin reductase 0.0048 0.0332 0.0576
Loa Loa (eye worm) isocitrate dehydrogenase 0.0078 0.0636 0.1103
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0044 0.0044
Trypanosoma cruzi zeta tubulin, putative 0.0164 0.1498 0.2633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0054
Brugia malayi CXXC zinc finger family protein 0.0029 0.0144 0.025
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0034 0.0014
Echinococcus multilocularis tubulin subunit TubB 0.0444 0.4307 0.4296
Brugia malayi hypothetical protein 0.0068 0.0535 0.0928
Brugia malayi Heterochromatin protein 1 0.007 0.0558 0.0969
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0151 0.0234
Echinococcus granulosus CREB binding protein 0.0017 0.0022 0.0002
Echinococcus multilocularis CREB binding protein 0.0077 0.0627 0.0609
Mycobacterium tuberculosis Conserved protein 0.0036 0.0218 0.0918
Loa Loa (eye worm) hypothetical protein 0.0036 0.0218 0.0378
Leishmania major beta tubulin 0.0576 0.5635 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0279 0.0515
Loa Loa (eye worm) glutathione reductase 0.0048 0.0332 0.0576
Echinococcus multilocularis FTZ F1 alpha 0.0149 0.1353 0.1336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0199 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.002 0.0034
Echinococcus granulosus Tubulin alpha 1 chain 0.0444 0.4307 0.4296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0218 0.0378
Loa Loa (eye worm) tubulin alpha-3 chain 0.023 0.2164 0.3757
Schistosoma mansoni tubulin subunit beta 0.0576 0.5635 0.5626
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.1498 0.2653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0149 0.1353 0.2348
Schistosoma mansoni jun-related protein 0.0069 0.0544 0.0525
Brugia malayi MH2 domain containing protein 0.004 0.0256 0.0445
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0945 0.1641
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0034 0.0014
Echinococcus multilocularis muscleblind protein 0.0151 0.1363 0.1346
Plasmodium falciparum alpha tubulin 1 0.0444 0.4307 0.7635
Echinococcus multilocularis thymidylate synthase 0.0108 0.094 0.0922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0764 0.0745
Loa Loa (eye worm) hypothetical protein 0.0036 0.0218 0.0378
Leishmania major beta tubulin 0.0576 0.5635 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0218 0.0378
Trypanosoma cruzi beta tubulin, putative 0.0576 0.5635 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0535 0.0516
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0167 0.1531 0.1514
Schistosoma mansoni smad1 5 8 and 0.004 0.0256 0.0237
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0764 0.1326
Echinococcus granulosus tubulin alpha chain 0.0444 0.4307 0.4296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2178 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.004 0.0256 0.0237
Loa Loa (eye worm) tubulin beta chain 0.0164 0.1498 0.2601
Schistosoma mansoni tubulin subunit beta 0.0576 0.5635 0.5626
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0068 0.0535 0.0516
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0504 0.0862
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0058 0.005
Leishmania major beta tubulin 0.0576 0.5635 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0044 0.0165
Schistosoma mansoni tubulin subunit beta 0.0576 0.5635 0.5626
Trypanosoma cruzi tubulin delta chain 0.0164 0.1498 0.2633
Loa Loa (eye worm) steroid hormone receptor 0.0149 0.1353 0.2348
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0044 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0162 0.0143
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0332 0.0556
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0151 0.0234
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0249 0.0434
Trypanosoma brucei beta tubulin 0.0576 0.5635 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.1375 0.2388
Mycobacterium ulcerans lipase LipD 0.0036 0.0218 0.1341
Leishmania major hypothetical protein, conserved 0.0036 0.0218 0.0353
Loa Loa (eye worm) CBP-B 0.0078 0.0636 0.1104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0535 0.0516
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0218 0.0199
Echinococcus granulosus mothers against decapentaplegic 5 0.004 0.0256 0.0237
Brugia malayi beta-tubulin, identical 0.0576 0.5635 0.9783
Echinococcus granulosus muscleblind protein 0.0151 0.1363 0.1346
Loa Loa (eye worm) hypothetical protein 0.0082 0.0672 0.1167
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0133 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.1498 0.2653
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0535 0.0928
Giardia lamblia Delta tubulin 0.0164 0.1498 0.2633
Echinococcus granulosus tubulin delta chain 0.0164 0.1498 0.1482
Schistosoma mansoni tubulin subunit beta 0.0576 0.5635 0.5626
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0218 0.0379
Mycobacterium tuberculosis Conserved protein 0.0036 0.0218 0.0918
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1066 0.4845
Brugia malayi photoreceptor-specific nuclear receptor 0.0149 0.1353 0.2348
Loa Loa (eye worm) hypothetical protein 0.0151 0.1363 0.2367
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1066 0.6996
Brugia malayi Tubulin alpha-2 chain 0.0444 0.4307 0.7477
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.0928
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.01
Echinococcus multilocularis transcription factor eb 0.0109 0.0945 0.0927
Echinococcus granulosus Tubulin alpha 1 chain 0.0444 0.4307 0.4296
Echinococcus multilocularis neuropeptide s receptor 0.047 0.4567 0.4556
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0152 0.1382 0.2427
Brugia malayi orphan nuclear receptor NR2E1 0.0068 0.0535 0.0928
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0068 0.0535 0.0516
Giardia lamblia Alpha-tubulin 0.0444 0.4307 0.7635
Leishmania major beta tubulin 0.0576 0.5635 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0164 0.1498 0.6849
Trichomonas vaginalis tubulin epsilon chain, putative 0.0164 0.1498 0.2653
Entamoeba histolytica hypothetical protein 0.0215 0.2008 0.3513
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.2242 0.3893
Trichomonas vaginalis tubulin alpha chain, putative 0.0378 0.3641 0.6458
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0277 0.0258
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0703 0.0684
Giardia lamblia Epsilon tubulin 0.0164 0.1498 0.2633
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0164 0.1498 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0444 0.4307 0.4296
Loa Loa (eye worm) hypothetical protein 0.0149 0.1353 0.2348
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0149 0.1353 0.2348
Loa Loa (eye worm) tubulin alpha 2 0.0066 0.052 0.0903
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.028 0.2663 0.4721
Onchocerca volvulus Bile acid receptor homolog 0.0149 0.1353 0.2773
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0952 0.1661
Brugia malayi nuclear receptor NHR-88 0.0149 0.1353 0.2348

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 150 nM Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production ChEMBL. 18947992
Ki (binding) = 18 nM Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cells ChEMBL. 18947992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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