Detailed information for compound 102597

Basic information

Technical information
  • TDR Targets ID: 102597
  • Name: 2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin -3-amine
  • MW: 253.299 | Formula: C15H15N3O
  • H donors: 1 H acceptors: 1 LogP: 3.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2n(c1N)cccc2OCc1ccccc1
  • InChi: 1S/C15H15N3O/c1-11-14(16)18-9-5-8-13(15(18)17-11)19-10-12-6-3-2-4-7-12/h2-9H,10,16H2,1H3
  • InChiKey: JGWVBIHUBXXZBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-amine
  • 8-benzyloxy-2-methyl-3-imidazo[1,2-a]pyridinamine
  • 2-methyl-8-phenylmethoxy-imidazo[1,2-a]pyridin-3-amine
  • (8-benzoxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)amine
  • 2-methyl-8-(phenylmethoxy)imidazo[3,2-a]pyridin-3-amine
  • 2-methyl-8-(phenylmethoxy)-3-imidazo[3,2-a]pyridinamine
  • [8-(benzyloxy)-2-methyl-imidazo[3,2-a]pyridin-3-yl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase, H+/K+ exchanging, beta polypeptide Starlite/ChEMBL References
Sus scrofa Potassium-transporting ATPase Starlite/ChEMBL References
Homo sapiens ATPase, H+/K+ exchanging, alpha polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Na+:K+ ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha-1 precursor, putative Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Echinococcus granulosus Na:K ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Candida albicans similar to Pichia farinosa Acu1p, putative P-type ATPase involved in high affinity uptake of potassium or sodium (CAF22247) Get druggable targets OG5_127003 All targets in OG5_127003
Candida albicans similar to Pichia farinosa Acu1p, putative P-type ATPase involved in high affinity uptake of potassium or sodium (CAF22247) Get druggable targets OG5_127003 All targets in OG5_127003
Brugia malayi Na,K-ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum ko:K01538 Na+/K+-exchanging ATPase [EC3.6.3.9], putative Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma mansoni na+/k+ atpase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Giardia lamblia Potassium-transporting ATPase alpha chain 1 Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) Na,K-ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative Get druggable targets OG5_127003 All targets in OG5_127003
Onchocerca volvulus Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Mycobacterium ulcerans metal cation transporter p-type ATPase a Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha Get druggable targets OG5_127003 All targets in OG5_127003
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus sodium:potassium dependent atpase beta subunit ATPase, H+/K+ exchanging, beta polypeptide 291 aa 264 aa 28.0 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.6 %
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 ATPase, H+/K+ exchanging, alpha polypeptide 1035 aa 861 aa 26.8 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 24.1 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Potassium-transporting ATPase   290 aa 258 aa 24.4 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 265 aa 22.3 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 254 aa 23.6 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta, putative Potassium-transporting ATPase   290 aa 256 aa 25.4 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 25.6 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 306 aa 26.1 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Potassium-transporting ATPase   290 aa 258 aa 23.6 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Drosophila melanogaster nervana 1 Potassium-transporting ATPase   290 aa 305 aa 23.9 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 21.3 %
Echinococcus granulosus nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.3 %
Loa Loa (eye worm) hypothetical protein Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Onchocerca volvulus Glutamate carboxypeptidase 2 homolog Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0611 0.1921
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0223 0.2266
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0103 0.098 0.0972
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0031 0.0164 0.1676
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0058 0.0491
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0107 0.0116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0218 0.021
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0181 0.055
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0031 0.0164 0.0481
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0058 0.0491
Brugia malayi Bromodomain containing protein 0.0156 0.1585 0.5027
Echinococcus multilocularis nervana 2 0.0103 0.098 0.0972
Giardia lamblia Cathepsin B precursor 0.0096 0.0908 1
Echinococcus granulosus calcium transporting atpase 0.0029 0.0141 0.0156
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0107 0.4431
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0029 0.0141 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0181 0.055
Loa Loa (eye worm) hypothetical protein 0.0103 0.098 0.3097
Schistosoma mansoni hypothetical protein 0.0187 0.1944 0.2284
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0497 0.0577
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0107 0.0313
Echinococcus granulosus heat shock protein 0.0036 0.0223 0.0254
Echinococcus multilocularis calcium transporting atpase 0.0029 0.0141 0.0133
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0223 0.2346
Loa Loa (eye worm) hypothetical protein 0.0147 0.1484 0.4705
Schistosoma mansoni intermediate filament proteins 0.003 0.0154 0.0172
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0347 0.04
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0497 0.0577
Echinococcus multilocularis lamin dm0 0.003 0.0154 0.0146
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0232 0.0714
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0103 0.098 0.0972
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0107 0.0313
Plasmodium vivax P-type ATPase4, putative 0.0032 0.0179 0.7897
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0058 0.0157
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0181 0.0204
Echinococcus multilocularis lysine specific demethylase 5A 0.0096 0.0908 0.09
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0029 0.0141 0.1332
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0096 0.0908 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0181 0.055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Loa Loa (eye worm) hypothetical protein 0.0136 0.1354 0.4289
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0181 0.0203
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0272
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.014 0.0972
Brugia malayi PHD-finger family protein 0.0052 0.0403 0.1259
Trypanosoma brucei P-type H+-ATPase, putative 0.0018 0.0023 0.0102
Schistosoma mansoni hypothetical protein 0.0043 0.0302 0.0347
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0497 0.0489
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.3127 0.368
Echinococcus multilocularis geminin 0.0187 0.1944 0.1937
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0107 0.0098
Schistosoma mansoni hypothetical protein 0.0032 0.0176 0.0198
Loa Loa (eye worm) calcium ATPase 0.0017 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0293 0.3146 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0029 0.0141 0.0408
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0414 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0181 0.0173
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.2785 0.2779
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0107 0.1039
Loa Loa (eye worm) hypothetical protein 0.0136 0.1354 0.4289
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0181 0.0173
Loa Loa (eye worm) TAR-binding protein 0.007 0.0611 0.1921
Echinococcus granulosus peregrin 0.0037 0.0237 0.027
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0103 0.098 0.1147
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0029 0.0141 0.0156
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0031 0.0164 0.1246
Echinococcus granulosus geminin 0.0187 0.1944 0.2284
Onchocerca volvulus 0.0053 0.0414 0.217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0181 0.055
Trichomonas vaginalis cation-transporting ATPase, putative 0.0031 0.0164 0.159
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0029 0.0141 0.142
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.2538
Echinococcus granulosus heat shock protein 90 0.0029 0.014 0.0156
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0154 0.0464
Brugia malayi PHD-finger family protein 0.0032 0.0181 0.0552
Brugia malayi intermediate filament protein 0.003 0.0154 0.0464
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0421 0.1315
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.014 0.1416
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0223 0.3468
Loa Loa (eye worm) cathepsin B 0.0096 0.0908 0.2868
Schistosoma mansoni tar DNA-binding protein 0.007 0.0611 0.0711
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0032 0.0179 0.1768
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.0141
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0223 0.195
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.4145
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0029 0.0141 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus endoplasmin 0.0029 0.014 0.0156
Echinococcus granulosus lamin 0.003 0.0154 0.0172
Schistosoma mansoni tar DNA-binding protein 0.007 0.0611 0.0711
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0953 0.1115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0181 0.055
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0292 0.3127 0.368
Brugia malayi ecdysteroid receptor 0.0032 0.0181 0.055
Loa Loa (eye worm) hypothetical protein 0.0053 0.0414 0.1294
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.1224 0.1435
Leishmania major calcium-transporting ATPase, putative 0.0029 0.0141 0.142
Echinococcus multilocularis nervana 2 0.0103 0.098 0.0972
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.014 0.0407
Schistosoma mansoni endoplasmin 0.0036 0.0223 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0181 0.055
Echinococcus granulosus lamin dm0 0.003 0.0154 0.0172
Loa Loa (eye worm) hypothetical protein 0.0071 0.0616 0.1938
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0181 0.0173
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0107 0.1039
Schistosoma mansoni endoplasmin 0.0036 0.0223 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0181 0.055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0014 0.0005
Trypanosoma cruzi P-type H+-ATPase, putative 0.0018 0.0023 0.0029
Loa Loa (eye worm) endoplasmin 0.0036 0.0223 0.0686
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0058 0.0157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0181 0.0173
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0018 0.0017 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0181 0.7995
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0018 0.0017 0.0026
Echinococcus multilocularis musashi 0.003 0.0154 0.0146
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.002 0.0039 0.2035
Trypanosoma cruzi ISWI complex protein 0.0032 0.0176 0.0522
Schistosoma mansoni hypothetical protein 0.0321 0.3457 0.407
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.159
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0644 0.2027
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0029 0.0141 0.0133
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0107 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0181 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0295 0.0338
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.159
Echinococcus granulosus nervana 2 0.0103 0.098 0.1147
Plasmodium vivax JmjC domain containing protein 0.0026 0.0107 0.4431
Echinococcus granulosus dna polymerase kappa 0.0021 0.0058 0.0058
Echinococcus granulosus nervana 2 0.0103 0.098 0.1147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0267 0.0305
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0058 0.0058
Loa Loa (eye worm) E1-E2 ATPase 0.0018 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Schistosoma mansoni heat shock protein 0.0036 0.0223 0.0254
Echinococcus multilocularis lamin 0.003 0.0154 0.0146
Schistosoma mansoni tar DNA-binding protein 0.007 0.0611 0.0711
Brugia malayi MH2 domain containing protein 0.0132 0.1315 0.4164
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0018 0.0017 0.0009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0218 0.0247
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0107 0.0116
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.4145
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0163 0.1664 0.1954
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0181 0.1875
Trichomonas vaginalis heat shock protein, putative 0.0029 0.014 0.1327
Brugia malayi RNA binding protein 0.007 0.0611 0.1921
Schistosoma mansoni zinc finger protein 0.0032 0.0176 0.0198
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.159
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0644 0.2026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0495
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Echinococcus granulosus lysine specific demethylase 5A 0.01 0.0953 0.1115
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0181 0.055
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0953 0.1115
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Loa Loa (eye worm) hypothetical protein 0.0089 0.0822 0.2593
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1315 0.4164
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0005
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0103 0.098 0.1147
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0029 0.0141 0.142
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0107 0.0116
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0053 0.0419 0.0411
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0154 0.0464
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0096 0.0908 0.2873
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0103 0.098 0.1147
Treponema pallidum heat shock protein 90 0.0029 0.014 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0005
Leishmania major P-type H -ATPase, putative 0.0018 0.0023 0.0102
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0181 0.0203
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0107 0.0116
Brugia malayi hypothetical protein 0.004 0.0267 0.0825
Schistosoma mansoni lamin 0.003 0.0154 0.0172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0096 0.0908 0.1062
Loa Loa (eye worm) jmjC domain-containing protein 0.01 0.0953 0.3011
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0107 0.0299
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0058 0.0058
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0181 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0152 0.0169
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0325 0.0317
Brugia malayi Na,K-ATPase alpha subunit 0.0057 0.0458 0.1432
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0414 0.0406
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Brugia malayi Membrane calcium atpase protein 3 0.0029 0.0141 0.0422
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0058 0.0049
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0414 0.0479
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0058 0.0393
Brugia malayi cathepsin B-like cysteine proteinase 0.0292 0.3127 0.994
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0031 0.0164 0.0481
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0103 0.098 0.1147
Loa Loa (eye worm) hypothetical protein 0.006 0.0497 0.1558
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.3127 0.368
Plasmodium falciparum calcium-transporting ATPase 0.0029 0.0141 0.6056
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0058 0.0049
Mycobacterium ulcerans heat shock protein 90 0.0029 0.014 0.2507
Onchocerca volvulus Huntingtin homolog 0.0136 0.1354 1
Onchocerca volvulus 0.0032 0.0181 0.0223
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0058 0.0393
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0223 0.0674
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0644 0.7051
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0096 0.0908 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0721 0.2271
Echinococcus multilocularis nervana 2 0.0103 0.098 0.0972
Schistosoma mansoni zinc finger protein 0.0041 0.0277 0.0317
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0032 0.0179 0.7897
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0119 0.1171 0.3706
Loa Loa (eye worm) hypothetical protein 0.0029 0.0148 0.0444
Brugia malayi E1-E2 ATPase family protein 0.002 0.0039 0.0097
Echinococcus granulosus transcription factor eb 0.0119 0.1171 0.1372
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Giardia lamblia Cathepsin B precursor 0.0096 0.0908 1
Echinococcus multilocularis cathepsin b 0.0292 0.3127 0.3121
Toxoplasma gondii cathepsin B 0.0096 0.0908 1
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0181 0.055
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0223 0.2346
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0103 0.098 0.1147
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0223 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0181 0.055
Echinococcus granulosus nervana 2 0.0103 0.098 0.1147
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0107 0.0098
Echinococcus granulosus intermediate filament protein 0.003 0.0154 0.0172
Onchocerca volvulus 0.0055 0.0442 0.2399
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0058 0.0894
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0292 0.3127 1
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0223 0.3468
Brugia malayi heat shock protein 90 0.0036 0.0223 0.0686
Echinococcus multilocularis peregrin 0.0037 0.0237 0.0229
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.014 1
Schistosoma mansoni hypothetical protein 0.0053 0.0421 0.0487
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0181 0.0203
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0044 0.0318 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0006
Trypanosoma brucei cysteine peptidase C (CPC) 0.0096 0.0908 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0103 0.098 0.0972
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0663 0.0656
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Brugia malayi jmjC domain containing protein 0.0026 0.0107 0.0313
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0644 1
Brugia malayi jmjC domain containing protein 0.0026 0.0107 0.0313
Brugia malayi jmjC domain containing protein 0.0026 0.0107 0.0313
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0181 0.0203
Schistosoma mansoni transmemberane protein 0.0103 0.098 0.1147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0218 0.0247
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.0141
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.2176 0.217
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.0141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0267 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0026
Echinococcus granulosus nervana 2 0.0103 0.098 0.1147
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0414 0.0406
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0032 0.0179 0.2783
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0181 0.0203
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0055 0.0442 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0644 0.0637
Echinococcus granulosus cathepsin b 0.0292 0.3127 0.368
Brugia malayi isocitrate dehydrogenase 0.0017 0.0014 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.0141
Leishmania major calcium-translocating P-type ATPase 0.0031 0.0164 0.1676
Toxoplasma gondii P-type ATPase PMA1 0.0018 0.0023 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0218 0.0247
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0103 0.098 0.1147
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0181 0.0203
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.2785 0.3277
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0014 0.0006
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0347 0.0339
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0017 0.001 0.0007
Plasmodium falciparum endoplasmin, putative 0.0022 0.0066 0.2478
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0181 0.0173
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0181 0.0203
Brugia malayi nuclear receptor NHR-88 0.0032 0.0181 0.055
Schistosoma mansoni hypothetical protein 0.004 0.0267 0.0305
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0058 0.347
Leishmania major DNA polymerase eta, putative 0.0021 0.0058 0.0491
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0031 0.0164 0.1676
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0181 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0181 0.055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0181 0.0203
Echinococcus multilocularis endoplasmin 0.0029 0.014 0.0132
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0181 0.0173
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0218 0.0247
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0644 0.7051
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0031 0.0164 0.1676
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0107 0.0116
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0181 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0029 0.0141 0.0156
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0058 0.0141
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0313
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0181 0.0203
Brugia malayi Bromodomain containing protein 0.0037 0.0237 0.073
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0058 0.0491
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0181 0.0173
Loa Loa (eye worm) hypothetical protein 0.0085 0.0777 0.2449
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0032 0.0179 0.0202
Trypanosoma brucei calcium-transporting ATPase, putative 0.0018 0.0017 0.0033
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0058 0.0491
Schistosoma mansoni DNA polymerase eta 0.0021 0.0058 0.0058
Echinococcus multilocularis transcription factor eb 0.0119 0.1171 0.1164
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0571 0.1794
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0414 0.217
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0181 0.0203
Echinococcus granulosus dna polymerase eta 0.0021 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.0026 0.0107 0.1039
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0058 0.347
Echinococcus multilocularis tar DNA binding protein 0.007 0.0611 0.0603
Trichomonas vaginalis cation-transporting ATPase, putative 0.0031 0.0164 0.159
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0325 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0181 0.055
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0107 0.0299
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0014 0.0017
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0223 0.0674
Schistosoma mansoni heat shock protein 0.0036 0.0223 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0181 0.055
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0053 0.0419 0.0485
Trichomonas vaginalis heat shock protein, putative 0.0029 0.014 0.1327
Trichomonas vaginalis heat shock protein, putative 0.0029 0.014 0.1327
Schistosoma mansoni microtubule-associated protein tau 0.0763 0.8482 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0644 0.2026
Loa Loa (eye worm) hypothetical protein 0.003 0.0154 0.0464
Schistosoma mansoni hypothetical protein 0.0187 0.1944 0.2284
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0119 0.1164 0.3685
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0663 0.0773
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0181 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1315 0.4164
Schistosoma mansoni tar DNA-binding protein 0.007 0.0611 0.0711
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0107 0.0098
Loa Loa (eye worm) hypothetical protein 0.0292 0.3127 0.994
Giardia lamblia Cathepsin B precursor 0.0096 0.0908 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0218 0.0247
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0497 0.0577
Onchocerca volvulus Alhambra homolog 0.0032 0.0181 0.0229
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Brugia malayi steroid hormone receptor 0.0032 0.0181 0.055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0181 0.0203
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.2176 0.2558
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0414 0.0479
Trypanosoma cruzi P-type H+-ATPase, putative 0.0018 0.0023 0.0029
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0031 0.0164 0.0183
Loa Loa (eye worm) intermediate filament protein 0.003 0.0154 0.0464
Onchocerca volvulus 0.0103 0.098 0.6883
Leishmania major calcium motive p-type ATPase, putative 0.0029 0.0141 0.142
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.159
Trichomonas vaginalis cation-transporting ATPase, putative 0.0031 0.0164 0.159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0181 0.055
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0046 0.0334 0.1037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0005
Onchocerca volvulus 0.0053 0.0421 0.2226
Echinococcus multilocularis zinc finger protein 0.0041 0.0277 0.0269
Plasmodium vivax calcium-transporting ATPase, putative 0.0032 0.0179 0.7897
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0029 0.0141 0.0156
Echinococcus granulosus heat shock protein 90 0.0036 0.0223 0.0254
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0181 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0031 0.0164 0.1676
Leishmania major P-type ATPase, putative 0.0029 0.0141 0.142
Trypanosoma brucei P-type H+-ATPase, putative 0.0018 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.072
Echinococcus granulosus phd:f box containing protein 0.0026 0.0107 0.0116
Schistosoma mansoni hypothetical protein 0.0032 0.0181 0.0204
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0107 0.1039
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0057 0.0458 0.1432
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0223 0.0674
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0107 0.0116
Schistosoma mansoni survival motor neuron protein 0.0053 0.0421 0.0487
Brugia malayi TAR-binding protein 0.007 0.0611 0.1921
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0066 0.0484
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0181 0.0223
Loa Loa (eye worm) hypothetical protein 0.0119 0.1164 0.3685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0181 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0181 0.055
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.014 0.0407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0181 0.055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0181 0.0173
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0218 0.021
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0031 0.0164 0.1676
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0107 0.0116
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0029 0.0141 0.0422
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0223 0.0686
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0313
Onchocerca volvulus Huntingtin homolog 0.0136 0.1354 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0058 0.0452
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0058 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0181 0.055
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0029 0.0141 0.0156
Leishmania major P-type H -ATPase, putative 0.0018 0.0023 0.0102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0181 0.055
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.014 0.0156
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0053 0.0419 0.425
Trypanosoma cruzi ISWI complex protein 0.0032 0.0176 0.0522
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0181 0.0173
Echinococcus multilocularis heat shock protein 0.0036 0.0223 0.0215
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Brugia malayi Bromodomain containing protein 0.008 0.0719 0.2266
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0046 0.0334 0.1037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0644 0.0751
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0107 0.0098
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0058 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus cathepsin b 0.0292 0.3127 0.368
Schistosoma mansoni jumonji domain containing protein 0.0141 0.1418 0.1663
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.014 0.5
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0057 0.0458 0.053
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0497 0.1558
Giardia lamblia PHD finger protein 15 0.0032 0.0181 0.1455
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.2538
Brugia malayi nuclear hormone receptor 0.0032 0.0181 0.055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0538
Echinococcus multilocularis nervana 2 0.0103 0.098 0.0972
Trypanosoma brucei unspecified product 0.0021 0.0058 0.0491
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0031 0.0164 0.159
Trypanosoma brucei ISWI complex protein 0.0032 0.0176 0.1819
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0014 0.0017
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Leishmania major hypothetical protein, conserved 0.0032 0.0176 0.1819
Loa Loa (eye worm) MBCTL1 0.006 0.0497 0.1558
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0152 0.0144
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0066 0.0484
Loa Loa (eye worm) hypothetical protein 0.0103 0.098 0.3097
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.1224 0.1217
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0644 0.2027
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0103 0.098 0.1147
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0644 0.0751
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0223 0.2346
Schistosoma mansoni bromodomain containing protein 0.0132 0.1309 0.1535
Plasmodium falciparum phd finger protein, putative 0.0032 0.0181 0.7995
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0497 0.0489
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0058 0.0058
Brugia malayi hypothetical protein 0.0262 0.2785 0.8851
Echinococcus granulosus Na:K ATPase alpha subunit 0.0053 0.0419 0.0485
Echinococcus multilocularis heat shock protein 90 0.0036 0.0223 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0032 0.0179 0.3476
Brugia malayi jmjC domain containing protein 0.0163 0.1664 0.5277
Echinococcus granulosus zinc finger protein 0.0041 0.0277 0.0317
Trypanosoma brucei calcium-translocating P-type ATPase 0.0029 0.0141 0.142
Plasmodium falciparum heat shock protein 90 0.0036 0.0223 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus microtubule associated protein 2 0.0763 0.8482 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0032 0.0179 0.0202
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0181 0.1875
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Echinococcus multilocularis microtubule associated protein 2 0.0763 0.8482 0.8481
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0414 0.0479
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0032 0.0179 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0181 0.055
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0218 0.0247
Brugia malayi mbt repeat family protein 0.0053 0.0414 0.1294
Leishmania major DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0029 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.055
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0181 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Loa Loa (eye worm) RNA binding protein 0.007 0.0611 0.1921
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0491
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0414 0.0479
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0056 0.0137
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0181 0.0204
Brugia malayi hypothetical protein 0.0136 0.1354 0.4289
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0058 0.0491
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0223 0.2346
Schistosoma mansoni coup transcription factor 0.0032 0.0181 0.0203
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.4145
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.0552
Loa Loa (eye worm) hypothetical protein 0.0262 0.2785 0.8851
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0014 0.0005
Brugia malayi jmjC domain containing protein 0.0026 0.0107 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0181 0.0173
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0302 0.0937
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0223 0.2346
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0267 0.0305
Schistosoma mansoni ATPase 0.0031 0.0164 0.0183
Schistosoma mansoni tar DNA-binding protein 0.007 0.0611 0.0711
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0031 0.0164 0.2538
Giardia lamblia Grp94/Hsp90 0.0029 0.014 0.0972
Leishmania major heat shock protein 83-1 0.0036 0.0223 0.2346
Echinococcus multilocularis dna polymerase eta 0.0021 0.0058 0.0049
Toxoplasma gondii P-type ATPase4, putative 0.0032 0.0179 0.1852
Echinococcus granulosus tar DNA binding protein 0.007 0.0611 0.0711
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0181 0.055
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0181 0.0203
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0223 1
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0031 0.0164 0.0481
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0157
Onchocerca volvulus 0.0103 0.098 0.6883
Schistosoma mansoni ATPase 0.0031 0.0164 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0107 0.0313
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0103 0.098 0.0972
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0029 0.0141 0.0408
Loa Loa (eye worm) hypothetical protein 0.0035 0.0218 0.0668
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0181 0.0203
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0027 0.0125 0.0791
Brugia malayi mbt repeat family protein 0.0053 0.0414 0.1294
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0163 0.1664 0.1657
Echinococcus multilocularis heat shock protein 90 0.0029 0.014 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.0293 0.3146 1
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0031 0.0164 0.0155
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0181 0.0203
Brugia malayi jmjC domain containing protein 0.01 0.0953 0.3011
Schistosoma mansoni lamin 0.003 0.0154 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0181 0.055
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0414 0.1294
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0031 0.0164 0.1676
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0103 0.098 0.1147
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0181 0.0203
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0611 0.1921
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0181 0.0203
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0223 0.0674
Echinococcus multilocularis cathepsin b 0.0292 0.3127 0.3121
Loa Loa (eye worm) hypothetical protein 0.0057 0.0458 0.1432
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0347 0.04
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0032 0.0179 0.0171
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0032 0.0179 0.1852
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.3127 0.368
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0017 0.001 0.0161
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0029 0.0141 0.0156
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.4145
Brugia malayi Endoplasmin precursor 0.0036 0.0223 0.0686
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0295 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0181 0.0203
Trypanosoma brucei heat shock protein, putative 0.0036 0.0223 0.2346
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0181 0.055
Plasmodium vivax endoplasmin, putative 0.0036 0.0223 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.1 mg kg-1 Inhibitory activity against histamine-stimulated gastric acid secretion in adult mengrel dogs, with surgically prepared Heidenhain pouches after intravenous administration ChEMBL. 1847427
ED50 (functional) = 0.1 mg kg-1 Intravenous effective dose of the compound for gastric antisecretory activity against histamine-stimulated gastric acid secretion in adult mongrel dogs ChEMBL. 9046332
ED50 (functional) = 0.1 mg kg-1 Antisecretory activity in histamine stimulated dogs at 5 mg/kg dose administered intravenously ChEMBL. 3669011
ED50 (functional) = 2 mg kg-1 Inhibitory activity against histamine-stimulated gastric acid secretion in adult mengrel dogs, with surgically prepared Heidenhain pouches after peroral administration ChEMBL. 1847427
ED50 (functional) = 2 mg kg-1 Inhibition of gastric acid secretion stimulated by histamine in dog was determined by per oral administration of the compound ; the regression was not significant ChEMBL. 3669012
ED50 (functional) = 2 mg kg-1 Peroral effective dose of the compound for gastric antisecretory activity against histamine-stimulated gastric acid secretion in adult mongrel dogs ChEMBL. 9046332
ED50 (functional) = 2 mg kg-1 Antisecretory activity in histamine stimulated dogs at 5 mg/kg dose administered orally ChEMBL. 3669011
ED50 (functional) = 6 mg kg-1 Cytoprotective activity against ethyle alcohol induced ulcers was determined in rats by per oral administration of the compound ChEMBL. 3669012
ED50 (functional) = 6 mg kg-1 Cytoprotective activity in rats against the ethyl alcohol stimulated ulcers measured as effective dose ChEMBL. 3669011
Histopathology (functional) HGM 0 Histopathology of the stomach was determined as HGM(Hyperplasia of grandular mucosa)in the presence of the compound. ChEMBL. 3669012
IC50 (functional) = 0.31 uM l-1 Compound was evaluated for the ability to inhibit H+/K+ -ATPase formation in rabbit gastric glands. ChEMBL. 1847427
IC50 (binding) = 0.31 uM l-1 Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glands ChEMBL. 9046332
IC50 (binding) = 0.31 uM l-1 Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glands ChEMBL. 9046332
IC50 (functional) = 0.89 uM l-1 Compound was evaluated for the ability to inhibit purified H+/K+ -ATPase at pH 7.4, by using gastric membrane vesicles prepared from hog stomach. ChEMBL. 1847427
IC50 (binding) = 0.89 uM l-1 Inhibition of purified H+/K+ ATPase at pH 7.4 as released inorganic phosphate from ATP using hog stomach gastric membrane vesicles ChEMBL. 9046332
IC50 (binding) = 0.89 uM l-1 Inhibition of purified H+/K+ ATPase at pH 7.4 as released inorganic phosphate from ATP using hog stomach gastric membrane vesicles ChEMBL. 9046332
Inhibition (functional) = 15 % percentage inhibition of acid secretion in histamine stimulated dogs at a dose of 0.05 mg/kg ChEMBL. 3669011
Inhibition (functional) = 41 % percentage inhibition of acid secretion in histamine stimulated dogs at a dose of 0.2 mg/kg ChEMBL. 3669011
Inhibition (functional) = 50 % Antisecretory activity in histamine stimulated dogs at 2 mg/kg dose administered orally ChEMBL. 3669011
Inhibition (functional) = 55 % Antisecretory activity in histamine stimulated dogs at 0.1 mg/kg dose administered intravenously ChEMBL. 3669011
Inhibition (functional) = 74 % Antisecretory activity in histamine stimulated dogs at 4 mg/kg dose administered orally ChEMBL. 3669011
Inhibition (functional) = 96 % Antisecretory activity in histamine stimulated dogs at 8 mg/kg dose administered orally ChEMBL. 3669011
Inhibition (functional) = 97 % Antisecretory activity in histamine stimulated dogs at 2 mg/kg dose administered intravenously ChEMBL. 3669011
Inhibition (functional) = 99 % Antisecretory activity in pylorus ligated rats at a 40 mg/kg dose administered intraperitoneally ChEMBL. 3669011
Organ weight (functional) = 1.09 g Organ weight(stomach)was determined after administration of the compound ChEMBL. 3669012
Organ weight ratio (functional) = 1 Organ weight ratio was determined for the compound with respect to (8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-yl) compound ChEMBL. 3669012
Organ weight ratio (functional) = 1.2 Organ weight ratio was determined for the compound :control ChEMBL. 3669012
pKa = 6.81 pKa value of the compound. ChEMBL. 1847427
pKa = 6.81 Dissociation constant (pKa) ChEMBL. 9046332
Protonated (functional) = 20.44 % The percent of compound protonated at pH 7.4 in purified H+/K+ -ATPase from rabbit gastric glands. ChEMBL. 1847427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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