Detailed information for compound 1030086

Basic information

Technical information
  • TDR Targets ID: 1030086
  • Name: 3-[3-tert-butylsulfanyl-5-(pyridin-2-ylmethox y)-1-[(4-pyridin-3-ylphenyl)methyl]indol-2-yl ]-2,2-dimethylpropanoic acid
  • MW: 579.752 | Formula: C35H37N3O3S
  • H donors: 1 H acceptors: 4 LogP: 6.8 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(Cc1n(Cc2ccc(cc2)c2cccnc2)c2c(c1SC(C)(C)C)cc(cc2)OCc1ccccn1)(C)C
  • InChi: 1S/C35H37N3O3S/c1-34(2,3)42-32-29-19-28(41-23-27-10-6-7-18-37-27)15-16-30(29)38(31(32)20-35(4,5)33(39)40)22-24-11-13-25(14-12-24)26-9-8-17-36-21-26/h6-19,21H,20,22-23H2,1-5H3,(H,39,40)
  • InChiKey: JLCRPHKUMRKGFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[3-tert-butylsulfanyl-5-(2-pyridylmethoxy)-1-[[4-(3-pyridyl)phenyl]methyl]indol-2-yl]-2,2-dimethyl-propanoic acid
  • 3-[3-(tert-butylthio)-5-(2-pyridylmethoxy)-1-[[4-(3-pyridyl)phenyl]methyl]-2-indolyl]-2,2-dimethylpropanoic acid
  • 3-[3-(tert-butylthio)-1-[4-(3-pyridyl)benzyl]-5-(2-pyridylmethoxy)indol-2-yl]-2,2-dimethyl-propionic acid
  • 3-[3-tert-butylsulfanyl-5-(pyridin-2-ylmethoxy)-1-[(4-pyridin-3-ylphenyl)methyl]indol-2-yl]-2,2-dimethyl-propanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens arachidonate 5-lipoxygenase-activating protein Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Schistosoma mansoni cell adhesion molecule 0.0114 0.0687 0.1048
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0271 0.2053 0.2485
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0167 0.1148 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0015 0.0018
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0048 0.011 0.0419
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0122 0.076 0.3283
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0161
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0047 0.0109 0.0411
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0082 0.0409 0.1711
Echinococcus multilocularis hypothetical protein 0.0072 0.0325 0.0393
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0151 0.1012 0.1226
Brugia malayi Sex muscle abnormal protein 5 0.0063 0.0245 0.0266
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0044 0.0081 0.0098
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.0015 0.0023
Trypanosoma brucei polo-like protein kinase 0.0301 0.2316 0.9898
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0101 0.0579 0.0628
Loa Loa (eye worm) AGC/NDR protein kinase 0.0151 0.1012 0.1098
Echinococcus multilocularis serine:threonine protein kinase 3 0.0285 0.2178 0.2638
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0047 0.0109 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0037 0.0015 0.0015
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0037 0.0017 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Leishmania major protein kinase, putative 0.0048 0.011 0.0413
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis serine:threonine protein kinase N2 0.0151 0.1012 0.1226
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Echinococcus granulosus serine:threonine protein kinase N2 0.0151 0.1012 0.1012
Echinococcus granulosus geminin 0.0194 0.1381 0.1381
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.076 0.1159
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0134 0.0861 0.373
Entamoeba histolytica casein kinase, putative 0.0066 0.0266 0.1138
Brugia malayi Protein kinase c protein 2 0.0121 0.075 0.0813
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.0015 0.0018
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0015 0.0015
Echinococcus granulosus microsomal glutathione S transferase 3 0.0135 0.0872 0.0872
Entamoeba histolytica PH domain containing protein kinase, putative 0.0173 0.1205 0.5149
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0037 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Trypanosoma cruzi Protein kinase B 0.0173 0.1205 0.5171
Echinococcus granulosus calcium activated potassium channel 0.0093 0.0506 0.0506
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) TK protein kinase 0.0141 0.0921 0.0999
Echinococcus multilocularis epidermal growth factor receptor 0.0704 0.5822 0.705
Echinococcus multilocularis rac serine:threonine kinase 0.0173 0.1205 0.1459
Loa Loa (eye worm) hypothetical protein 0.0089 0.0474 0.0514
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus hemicentin 1 0.0041 0.0057 0.0057
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0065 0.0262 0.0284
Echinococcus multilocularis tyrosine protein kinase Srms 0.0141 0.0921 0.1115
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Echinococcus multilocularis ephrin type A receptor 4 A 0.0112 0.0673 0.0815
Leishmania major casein kinase, putative 0.0066 0.0266 0.1093
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Brugia malayi P38 map kinase family protein 2 0.017 0.1174 0.1273
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Plasmodium vivax protein kinase, putative 0.0043 0.0066 0.0456
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0131 0.0832 0.3513
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Brugia malayi putative serine/threonine kinase SADA gamma 0.0047 0.0109 0.0119
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0722 0.5973 0.6478
Entamoeba histolytica serine/threonine kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0883 0.0958
Onchocerca volvulus 0.0148 0.0987 0.1906
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.017 0.1174 0.5037
Echinococcus multilocularis protein kinase shaggy 0.0134 0.0861 0.1043
Schistosoma mansoni ste20-related kinase 0.0224 0.1647 0.2513
Loa Loa (eye worm) hypothetical protein 0.0131 0.0834 0.0904
Entamoeba histolytica cell division protein kinase 2, putative 0.0122 0.076 0.3246
Loa Loa (eye worm) hypothetical protein 0.0111 0.0662 0.0718
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0399 0.1653
Loa Loa (eye worm) hypothetical protein 0.0048 0.011 0.0119
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0515 0.4176 0.5057
Onchocerca volvulus 0.0071 0.0318 0.0614
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.1602 0.2444
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0169 0.1166 0.1412
Loa Loa (eye worm) TK/DDR protein kinase 0.0037 0.0015 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0289 0.1178
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0095 0.052 0.0629
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0015 0.0016
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0057 0.0061
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0167 0.1148 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0361 0.2837 0.3077
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0015 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Schistosoma mansoni tyrosine kinase 0.0271 0.2053 0.3132
Echinococcus multilocularis nervana 2 0.0146 0.0968 0.1172
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0044 0.0081 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0059 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0289 0.044
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0256 0.1924 0.2087
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Brugia malayi Variant SH3 domain containing protein 0.0063 0.0245 0.0266
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Brugia malayi cell division control protein 2 homolog 0.0122 0.076 0.0824
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0109 0.0167
Schistosoma mansoni serine/threonine kinase 0.0151 0.1012 0.1545
Brugia malayi diacylglycerol kinase 0.0052 0.0148 0.0161
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.0015 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1034 0.4382
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0047 0.0109 0.0132
Entamoeba histolytica serine/threonine kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0066 0.0266 0.0289
Entamoeba histolytica protein kinase, putative 0.0037 0.0017 0.0073
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0289 0.0313
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Echinococcus multilocularis titin 0.0043 0.0074 0.0089
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0095 0.052 0.0563
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0015 0.0023
Schistosoma mansoni diacylglycerol kinase theta 0.0052 0.0148 0.0226
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0289 0.119
Toxoplasma gondii aurora kinase 0.0154 0.1034 0.4492
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.2224 0.2413
Plasmodium vivax calcium-dependent protein kinase, putative 0.0048 0.011 0.0839
Onchocerca volvulus 0.0037 0.0015 0.0028
Plasmodium vivax protein kinase Crk2 0.0122 0.076 0.6571
Trypanosoma cruzi casein kinase, putative 0.0066 0.0266 0.1093
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0134 0.0861 0.3677
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus tyrosine protein kinase otk 0.0041 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Schistosoma mansoni protein kinase 0.0083 0.0423 0.0645
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.0015 0.0018
Echinococcus multilocularis cyclin dependent kinase 1 0.0122 0.076 0.092
Schistosoma mansoni tyrosine kinase 0.0422 0.3364 0.5133
Echinococcus granulosus nervana 2 0.0146 0.0968 0.0968
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0167 0.1148 0.4925
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.0015 0.0023
Brugia malayi STE20-like kinase MST 0.0285 0.2178 0.2363
Toxoplasma gondii CMGC kinase, CK2 family 0.01 0.0567 0.2436
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0506 0.2111
Onchocerca volvulus 0.0037 0.0015 0.0028
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.0015 0.0016
Echinococcus granulosus cyclin dependent kinase 0.0122 0.076 0.076
Echinococcus granulosus serine:threonine kinase SAD 1 0.0047 0.0109 0.0109
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0127 0.0798 0.3404
Echinococcus multilocularis protein kinase c eta type 0.0052 0.0148 0.018
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0031 0.0034
Onchocerca volvulus 0.0071 0.0318 0.0614
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0302 0.0461
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0122 0.076 0.0824
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0015 0.0016
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0057 0.0195 0.0796
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0082 0.0409 0.1746
Echinococcus multilocularis natriuretic peptide receptor 1 0.0037 0.0015 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0237 0.0981
Echinococcus granulosus tyrosine protein kinase Srms 0.0071 0.0318 0.0318
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.076 0.3203
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus titin 0.0043 0.0074 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0861 0.3639
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0066 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0037 0.0019 0.0029
Onchocerca volvulus 0.0164 0.1123 0.2168
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.0015 0.0018
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Entamoeba histolytica protein kinase, putative 0.0134 0.0861 0.3679
Schistosoma mansoni nck2/grb4 0.0063 0.0245 0.0374
Entamoeba histolytica ankyrin repeat protein 0.0037 0.0015 0.0063
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0066 0.0266 0.1093
Echinococcus multilocularis insulin receptor 0.0512 0.4151 0.5027
Echinococcus multilocularis neuroglian 0.0109 0.0646 0.0782
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0063 0.0245 0.0266
Echinococcus granulosus tyrosine protein kinase 0.0037 0.0015 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Plasmodium falciparum calcium-dependent protein kinase 2 0.0048 0.011 0.0839
Echinococcus granulosus integrin linked protein kinase 0.0037 0.0015 0.0015
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0376 0.0408
Schistosoma mansoni hypothetical protein 0.0072 0.0325 0.0496
Plasmodium vivax glycogen synthase kinase 3, putative 0.0134 0.0861 0.7465
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0251 0.1877 0.1877
Brugia malayi Guanylyl cyclase protein 23 0.0037 0.0015 0.0016
Echinococcus granulosus receptor type guanylyl cyclase 0.0037 0.0015 0.0015
Trichomonas vaginalis STE family protein kinase 0.0083 0.0423 0.1754
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Echinococcus granulosus protein tyrosine kinase 0.0037 0.0015 0.0015
Giardia lamblia Kinase, STE STE20 0.0083 0.0423 0.1772
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0037 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0106 0.0614 0.0666
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0081 0.0399 0.167
Trichomonas vaginalis STE family protein kinase 0.0083 0.0423 0.1754
Schistosoma mansoni nephrin 0.0044 0.0081 0.0124
Echinococcus multilocularis epidermal growth factor receptor 0.0458 0.3683 0.4459
Brugia malayi Pleckstrin Homology Domain 0.0058 0.0205 0.0222
Brugia malayi Hr1 repeat family protein 0.0151 0.1012 0.1098
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0169 0.1166 0.1412
Echinococcus multilocularis integrin linked protein kinase 0.0037 0.0015 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Loa Loa (eye worm) hypothetical protein 0.0072 0.0325 0.0352
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0189 0.134 0.1622
Loa Loa (eye worm) hypothetical protein 0.0096 0.0535 0.0581
Echinococcus granulosus protein kinase c epsilon type 0.0205 0.1477 0.1477
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0093 0.0506 0.0548
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Trypanosoma brucei cdc2-related kinase 1 0.0122 0.076 0.3203
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.0015 0.0015
Echinococcus granulosus kinase suppressor of Ras 1 0.0037 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0169 0.1166 0.1412
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0169 0.1168 0.1267
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0153 0.1027 0.1244
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1034 0.4382
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus cyclin dependent kinase 1 0.0122 0.076 0.076
Trichomonas vaginalis CK1 family protein kinase 0.0066 0.0266 0.1082
Brugia malayi serine/threonine protein kinase 6 0.0154 0.1034 0.1121
Giardia lamblia Kinase, CMGC CDK 0.0122 0.076 0.3236
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0048 0.011 0.0839
Entamoeba histolytica tyrosin kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica casein kinase 1, putative 0.0066 0.0266 0.1138
Leishmania major protein kinase, putative 0.0082 0.0409 0.1711
Brugia malayi Ras association domain family 1 isoform A 0.0052 0.0148 0.0161
Loa Loa (eye worm) AGC/PKN protein kinase 0.0151 0.1012 0.1098
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.2255 0.344
Brugia malayi C-terminal src kinase protein 1 0.0037 0.0015 0.0016
Brugia malayi Protein kinase domain 0.0083 0.0423 0.0458
Echinococcus multilocularis hemicentin 1 0.0041 0.0057 0.0069
Brugia malayi integrin-linked kinase 0.0037 0.0015 0.0016
Trypanosoma cruzi casein kinase II, putative 0.01 0.0567 0.2401
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0376 0.0574
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.0015 0.0016
Onchocerca volvulus 0.0071 0.0318 0.0614
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Entamoeba histolytica serine/threonine kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Brugia malayi map kinase activated protein kinase protein 2 0.0448 0.359 0.3894
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0167 0.1148 0.1391
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Echinococcus multilocularis heat shock protein 70 0.0037 0.0015 0.0018
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0301 0.2316 0.2805
Brugia malayi protein kinase C II. 0.0205 0.1477 0.1602
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.0073
Echinococcus granulosus casein kinase I alpha 0.0066 0.0266 0.0266
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0161 0.11 0.1332
Onchocerca volvulus 0.0043 0.0074 0.0143
Echinococcus multilocularis myosin iiia 0.0082 0.0409 0.0495
Loa Loa (eye worm) SRC-1 0.0169 0.1166 0.1265
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0081 0.0399 0.167
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0169 0.1166 0.1166
Schistosoma mansoni tyrosine kinase 0.0512 0.4151 0.6334
Echinococcus multilocularis 0.0205 0.1482 0.1794
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Schistosoma mansoni GTPase activating protein 0.0035 0.0001 0.0002
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0063 0.0245 0.0374
Giardia lamblia Kinase, CK1 Casein kinase 0.0066 0.0266 0.1093
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0219 0.1602 0.1939
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.01 0.0567 0.4876
Echinococcus granulosus serine threonine protein kinase nrc 0.0167 0.1148 0.1148
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica protein kinase, putative 0.0304 0.234 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0345 0.1475
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0506 0.0771
Schistosoma mansoni hypothetical protein 0.0467 0.3761 0.5739
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0068 0.0289 0.2417
Schistosoma mansoni atypical protein kinase C 0.0308 0.2379 0.363
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0205 0.1477 0.1602
Echinococcus multilocularis c src tyrosine kinase 0.01 0.0564 0.0682
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0448 0.359 0.359
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0015 0.0018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0057 0.0061
Entamoeba histolytica tyrosin kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica protein kinase, putative 0.0304 0.234 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0015 0.0015
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0154 0.1034 0.4418
Echinococcus granulosus contactin 0.0044 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0124 0.0779 0.0845
Onchocerca volvulus 0.0037 0.0015 0.0028
Loa Loa (eye worm) TK/EPH protein kinase 0.0133 0.0853 0.0925
Echinococcus multilocularis death associated protein kinase 1 0.0984 0.8258 1
Schistosoma mansoni protein kinase 0.0048 0.011 0.0168
Brugia malayi RhoGAP domain containing protein 0.0073 0.0327 0.0355
Echinococcus granulosus neuroglian 0.0109 0.0646 0.0646
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Entamoeba histolytica protein kinase, putative 0.0154 0.1034 0.4418
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0037 0.0015 0.0023
Echinococcus granulosus tyrosine protein kinase ABL1 0.0317 0.245 0.245
Plasmodium falciparum calcium-dependent protein kinase 5 0.0048 0.011 0.0839
Brugia malayi Protein kinase domain containing protein 0.0206 0.149 0.1616
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0053 0.0161 0.0161
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0189 0.134 0.134
Trypanosoma brucei protein kinase, putative 0.0081 0.0399 0.1653
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0046 0.01 0.0367
Echinococcus granulosus tyrosine protein kinase Src64B 0.0169 0.1166 0.1166
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0161 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0131 0.0837 0.3538
Echinococcus granulosus tyrosine protein kinase Fyn 0.0169 0.1166 0.1166
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Echinococcus granulosus peroxidasin 0.0042 0.0059 0.0059
Echinococcus granulosus NCK adaptor protein 0.0063 0.0245 0.0245
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0081 0.0399 0.167
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0289 0.044
Loa Loa (eye worm) hypothetical protein 0.0092 0.0499 0.0541
Echinococcus granulosus growth factor receptor bound protein 2 0.0063 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0015 0.0028
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.0195 0.0785
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.076 0.3203
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0126 0.0795 0.3389
Echinococcus granulosus roundabout 2 0.0134 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0722 0.5973 0.6478
Echinococcus multilocularis serine:threonine protein kinase N2 0.0151 0.1012 0.1226
Entamoeba histolytica serine/threonine kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica diacylglycerol kinase, putative 0.0052 0.0148 0.0634
Brugia malayi Raf kinase 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.01 0.0567 0.0615
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.0175
Brugia malayi Protein kinase domain containing protein 0.021 0.152 0.1648
Trichomonas vaginalis CK1 family protein kinase 0.0066 0.0266 0.1082
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0113
Echinococcus multilocularis tyrosine protein kinase HCK 0.0106 0.0617 0.0748
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Echinococcus granulosus epidermal growth factor receptor 0.0704 0.5822 0.5822
Schistosoma mansoni neuroglian 0.0044 0.0081 0.0124
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0345 0.1475
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0015 0.0016
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.021 0.152 0.152
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0037 0.0015 0.0016
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0285 0.2178 0.2363
Echinococcus multilocularis FL cytokine receptor 0.0037 0.0015 0.0018
Brugia malayi hypothetical protein 0.0071 0.0318 0.0345
Echinococcus multilocularis Rac GTPase activating protein 1 0.0124 0.0779 0.0944
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.003 0.0032
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0448 0.359 0.3894
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0423 0.0512
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Trypanosoma cruzi casein kinase, putative 0.0066 0.0266 0.1093
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Schistosoma mansoni diacylglycerol kinase theta 0.0052 0.0148 0.0226
Loa Loa (eye worm) TK/RYK protein kinase 0.0037 0.0015 0.0016
Echinococcus granulosus casein kinase I alpha 0.0066 0.0266 0.0266
Echinococcus multilocularis unc 13 (munc13) 0.0053 0.0161 0.0195
Entamoeba histolytica diacylglycerol kinase, putative 0.0052 0.0148 0.0634
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0046 0.01 0.0109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase, putative 0.0154 0.1034 0.4418
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Schistosoma mansoni tyrosine kinase 0.01 0.0564 0.086
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0037 0.0015 0.0018
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase, putative 0.0056 0.0181 0.0772
Giardia lamblia Kinase, CMGC CK2 0.01 0.0567 0.2401
Entamoeba histolytica tyrosin kinase, putative 0.0037 0.0015 0.0063
Schistosoma mansoni tyrosine kinase 0.01 0.0564 0.086
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0037 0.0015 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Schistosoma mansoni tyrosine kinase 0.0458 0.3683 0.5619
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0068 0.0289 0.1208
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0117 0.0716 0.0777
Echinococcus granulosus Immunoglobulin 0.0089 0.0474 0.0474
Brugia malayi Protein kinase domain containing protein 0.0151 0.1012 0.1098
Brugia malayi Temporarily assigned gene name protein 59 0.0152 0.1022 0.1109
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Schistosoma mansoni tyrosine kinase 0.0169 0.1166 0.1779
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1034 0.4382
Entamoeba histolytica protein kinase, putative 0.0066 0.0267 0.1139
Echinococcus multilocularis serine:threonine protein kinase 0.0117 0.0711 0.0861
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0048 0.011 0.0119
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.0861 0.3679
Echinococcus multilocularis twitchin 0.0041 0.0049 0.006
Trichomonas vaginalis STE family protein kinase 0.0143 0.0938 0.397
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0169 0.1166 0.1412
Onchocerca volvulus Serine\/threonine kinase homolog 0.0301 0.2316 0.4473
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0271 0.2053 0.2485
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0015 0.0023
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0252 0.1885 0.2282
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0049 0.0075
Echinococcus multilocularis raf serine:threonine protein kinase 0.0089 0.0467 0.0565
Schistosoma mansoni protein kinase 0.0058 0.02 0.0305
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.017 0.1174 0.5037
Schistosoma mansoni tyrosine kinase 0.0422 0.3364 0.5133
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0423 0.0512
Giardia lamblia Kinase, CMGC GSK 0.0134 0.0861 0.3677
Brugia malayi RhoGAP domain containing protein 0.0124 0.0779 0.0845
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0052 0.0148 0.0161
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Trypanosoma cruzi cdc2-related kinase 3 0.0122 0.076 0.3236
Brugia malayi MH2 domain containing protein 0.0136 0.0883 0.0958
Brugia malayi Variant SH3 domain containing protein 0.0087 0.0452 0.049
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0151 0.1012 0.1012
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0266 0.0406
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0154 0.1034 0.1034
Echinococcus granulosus casein kinase I alpha 0.0066 0.0266 0.0266
Entamoeba histolytica protein kinase 2, putative 0.0167 0.1148 0.4907
Schistosoma mansoni tyrosine kinase 0.0229 0.1689 0.2577
Echinococcus multilocularis cyclin dependent kinase 5 0.0122 0.076 0.092
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Trichomonas vaginalis STE family protein kinase 0.0083 0.0423 0.1754
Brugia malayi Protein kinase domain containing protein 0.0304 0.234 0.2538
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0301 0.2316 0.2512
Schistosoma mansoni protein kinase 0.0048 0.011 0.0168
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0048 0.011 0.0839
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Entamoeba histolytica hypothetical protein 0.0126 0.0795 0.3397
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0927 0.7755 0.9391
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0078 0.0376 0.0376
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Schistosoma mansoni tyrosine kinase 0.0078 0.0375 0.0572
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0143 0.0938 0.4068
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Echinococcus granulosus mitogen activated protein kinase 14 0.017 0.1174 0.1174
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0057 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.11 0.1678
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Onchocerca volvulus 0.0037 0.0015 0.0028
Echinococcus multilocularis receptor type guanylyl cyclase 0.0037 0.0015 0.0018
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.0015 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1034 0.4382
Giardia lamblia Kinase, PLK 0.0301 0.2316 1
Entamoeba histolytica protein kinase, putative 0.0064 0.0256 0.1095
Schistosoma mansoni septate junction protein 0.0041 0.0057 0.0086
Trypanosoma cruzi casein kinase, putative 0.0066 0.0266 0.1093
Plasmodium falciparum glycogen synthase kinase 3 0.0134 0.0861 0.7465
Trypanosoma cruzi cdc2-related kinase 3 0.0122 0.076 0.3236
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.0795 0.3397
Plasmodium falciparum NIMA related kinase 1 0.0143 0.0938 0.8143
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0092 0.0499 0.0541
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Echinococcus multilocularis casein kinase I alpha 0.0066 0.0266 0.0322
Onchocerca volvulus 0.0155 0.1044 0.2016
Echinococcus granulosus twitchin 0.013 0.0826 0.0826
Echinococcus granulosus N chimaerin 0.0087 0.0453 0.0453
Echinococcus multilocularis casein kinase i 0.0066 0.0266 0.0322
Entamoeba histolytica PH domain containing protein kinase, putative 0.0173 0.1205 0.5149
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0037 0.0019 0.0021
Schistosoma mansoni serine/threonine RGC 0.0037 0.0015 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.134 0.2044
Toxoplasma gondii histone kinase SNF1, putative 0.0047 0.0109 0.0417
Echinococcus multilocularis dnaJ subfamily B 0.0467 0.3761 0.4555
Schistosoma mansoni tyrosine kinase 0.0282 0.2147 0.3275
Echinococcus granulosus lachesin 0.0041 0.0057 0.0057
Echinococcus multilocularis hemicentin 1 0.0041 0.0057 0.0069
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0044 0.0081 0.0124
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Brugia malayi Variant SH3 domain containing protein 0.0063 0.0245 0.0266
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.035
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0044 0.0081 0.0088
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Schistosoma mansoni hypothetical protein 0.0194 0.1381 0.2106
Schistosoma mansoni rac gtpase activating protein 0.0124 0.0779 0.1189
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Loa Loa (eye worm) protein kinase domain-containing protein 0.0037 0.0015 0.0016
Entamoeba histolytica hypothetical protein 0.0052 0.0148 0.0634
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0109 0.0167
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0037 0.0015 0.0016
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0078 0.0376 0.0455
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.0195 0.0785
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0883 0.0958
Brugia malayi SRC-1 0.0169 0.1166 0.1265
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0164 0.1123 0.1218
Brugia malayi ribosomal protein S6 kinase alpha 3 0.012 0.0742 0.0804
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0301 0.2316 0.2316
Leishmania major protein kinase, putative 0.0154 0.1034 0.4427
Echinococcus granulosus neuroglian 0.0044 0.0081 0.0081
Echinococcus granulosus dual specificity 0.0126 0.0795 0.0795
Entamoeba histolytica protein kinase, putative 0.0048 0.011 0.0469
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica protein kinase, putative 0.0064 0.0256 0.1095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0074 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0242 0.0977
Giardia lamblia Aurora kinase 0.0154 0.1034 0.4427
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0037 0.0015 0.0016
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Echinococcus granulosus protein kinase shaggy 0.0134 0.0861 0.0861
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0071 0.0318 0.136
Schistosoma mansoni protein kinase 0.01 0.0567 0.0866
Trichomonas vaginalis AGC family protein kinase 0.0151 0.1012 0.429
Echinococcus granulosus nervana 2 0.0146 0.0968 0.0968
Trypanosoma brucei aurora B kinase 0.0154 0.1034 0.4382
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Schistosoma mansoni protein kinase C 0.0053 0.0161 0.0246
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0037 0.0015 0.0018
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus multilocularis kinase suppressor of Ras 1 0.0037 0.0015 0.0018
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0081 0.0399 0.1653
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Schistosoma mansoni tyrosine kinase 0.0169 0.1166 0.1779
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0146 0.0968 0.1172
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0095 0.052 0.0629
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0037 0.0019 0.0019
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0066 0.0266 0.0289
Onchocerca volvulus 0.0051 0.0143 0.0277
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.0015 0.0016
Loa Loa (eye worm) TK/CSK protein kinase 0.0037 0.0015 0.0016
Echinococcus granulosus roundabout 2 0.0044 0.0081 0.0081
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0066 0.0267 0.0323
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.0015 0.0015
Brugia malayi protein kinase C3,putative 0.0171 0.1181 0.1281
Brugia malayi casein kinase I 0.0066 0.0266 0.0289
Echinococcus granulosus tyrosine protein kinase Fyn 0.0169 0.1166 0.1166
Plasmodium vivax unspecified product 0.01 0.0567 0.4876
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0795 0.1213
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0081 0.0399 0.167
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Schistosoma mansoni protein kinase 0.0083 0.0423 0.0645
Loa Loa (eye worm) hypothetical protein 0.013 0.083 0.09
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.0015 0.0015
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0089 0.0474 0.0723
Trypanosoma brucei cdc2-related kinase 3 0.0122 0.076 0.3203
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.01 0.0153
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0082 0.0409 0.1746
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0047 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0131 0.0834 0.0904
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.0015 0.0015
Echinococcus multilocularis mitogen activated protein kinase 14 0.017 0.1174 0.1422
Echinococcus granulosus insulin receptor 0.0512 0.4151 0.4151
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.0133
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0037 0.0015 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Schistosoma mansoni cell adhesion molecule 0.0041 0.0057 0.0086
Echinococcus granulosus Protein kinase C brain isozyme 0.0252 0.1885 0.1885
Echinococcus multilocularis protein tyrosine kinase 0.0037 0.0015 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0376 0.1553
Echinococcus granulosus mitogen activated protein kinase 0.0081 0.0399 0.0399
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0089 0.0474 0.0574
Entamoeba histolytica protein kinase, putative 0.0106 0.0617 0.2639
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0047 0.0109 0.0834
Giardia lamblia Kinase, NEK 0.0143 0.0938 0.401
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.0133
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Brugia malayi Protein kinase domain containing protein 0.0151 0.1012 0.1098
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0047 0.0104 0.0126
Echinococcus granulosus tyrosine protein kinase HCK 0.0106 0.0617 0.0617
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0143 0.0939 0.0939
Brugia malayi Protein kinase domain containing protein 0.1095 0.922 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0169 0.1166 0.1412
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0087 0.0452 0.0547
Trypanosoma cruzi casein kinase, putative 0.0066 0.0266 0.1093
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0042 0.0058 0.0088
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.0195 0.0777
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0939 0.1432
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0506 0.0771
Onchocerca volvulus 0.0574 0.4689 0.9054
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Schistosoma mansoni septate junction protein 0.0041 0.0057 0.0086
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0187 0.0202
Toxoplasma gondii AGC kinase 0.0068 0.0289 0.1208
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0037 0.0015 0.0028
Echinococcus multilocularis cyclin dependent kinase 0.0122 0.076 0.092
Trichomonas vaginalis AGC family protein kinase 0.0151 0.1012 0.429
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.1034 0.1577
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Echinococcus multilocularis serine threonine protein kinase 0.02 0.1433 0.1735
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.076 0.1159
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0169 0.1166 0.1412
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Brugia malayi Tyrosine-protein kinase abl-1 0.0193 0.1379 0.1495
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0154 0.1034 0.4418
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0095 0.052 0.0793
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Loa Loa (eye worm) AUR protein kinase 0.0154 0.1034 0.1121
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus roundabout 2 0.0044 0.0081 0.0081
Trypanosoma cruzi p21-activated kinase 3, putative 0.0046 0.01 0.0371
Loa Loa (eye worm) hypothetical protein 0.0095 0.052 0.0563
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0567 0.2425
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0251 0.1877 0.2273
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0037 0.0015 0.0016
Echinococcus multilocularis cyclin dependent kinase 1 0.0122 0.076 0.092
Loa Loa (eye worm) TK/INSR protein kinase 0.0512 0.4151 0.4503
Brugia malayi hypothetical protein 0.0037 0.0015 0.0016
Brugia malayi hypothetical protein 0.0037 0.0015 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0788 0.6555 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0081 0.0088
Onchocerca volvulus 0.0037 0.0015 0.0028
Trichomonas vaginalis STE family protein kinase 0.0083 0.0423 0.1754
Echinococcus multilocularis lachesin 0.0041 0.0057 0.0069
Brugia malayi Cam kinase protein 1 0.0048 0.011 0.0119
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0037 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0216 0.1575 0.1708
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0151 0.1012 0.1226
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0044 0.0081 0.0098
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0066 0.0267 0.0267
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Plasmodium falciparum protein kinase, putative 0.0057 0.0195 0.1594
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0134 0.0861 0.3677
Schistosoma mansoni hypothetical protein 0.0194 0.1381 0.2106
Leishmania major protein kinase A catalytic subunit isoform 2 0.0068 0.0289 0.119
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0047 0.0109 0.0411
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Echinococcus granulosus tyrosine protein kinase Src42A 0.0169 0.1166 0.1166
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0169 0.1166 0.1166
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0376 0.0408
Echinococcus multilocularis mitogen activated protein kinase 11 0.017 0.1174 0.1422
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.0015 0.0015
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase, putative 0.0058 0.02 0.0853
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0399 0.1653
Echinococcus granulosus protein kinase C gamma type 0.02 0.1433 0.1433
Entamoeba histolytica p21-activated kinase 0.009 0.0479 0.2047
Echinococcus granulosus tyrosine kinase 0.0071 0.0318 0.0318
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.017 0.1174 0.4985
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1095 0.922 1
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0399 0.1653
Schistosoma mansoni ephrin receptor 0.0039 0.004 0.006
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Entamoeba histolytica protein kinase domain containing protein 0.0154 0.1034 0.4418
Echinococcus multilocularis nervana 2 0.0146 0.0968 0.1172
Schistosoma mansoni tyrosine protein kinase 0.0037 0.0015 0.0023
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0008 0.0009
Brugia malayi serine/threonine-protein kinase 6 0.0154 0.1034 0.1121
Echinococcus granulosus ephrin type A receptor 4 A 0.0112 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0161
Giardia lamblia Kinase, NEK 0.0143 0.0938 0.401
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0143 0.0938 0.8143
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus multilocularis PAK box P21 Rho binding 0.0058 0.02 0.0242
Echinococcus multilocularis dual specificity 0.0126 0.0795 0.0963
Loa Loa (eye worm) CAMK/PIM protein kinase 0.021 0.152 0.1648
Brugia malayi MAP kinase sur-1 0.0081 0.0399 0.0433
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0297 0.2284 0.2477
Loa Loa (eye worm) TK/ALK protein kinase 0.0037 0.0015 0.0016
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Brugia malayi protein unc-22 0.0043 0.0074 0.008
Brugia malayi Protein kinase domain containing protein 0.0512 0.4151 0.4503
Giardia lamblia Rho GAP, putative 0.0073 0.0327 0.1358
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0081 0.0399 0.167
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0161 0.11 0.11
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0499 0.0541
Entamoeba histolytica receptor protein kinase, putative 0.0037 0.0015 0.0063
Echinococcus multilocularis casein kinase I alpha 0.0066 0.0266 0.0322
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.011
Entamoeba histolytica serine/threonine kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus tyrosine protein kinase shark 0.0071 0.0318 0.0318
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.0015 0.0018
Echinococcus granulosus mitogen activated protein kinase 3 0.0081 0.0399 0.0399
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.01 0.0153
Schistosoma mansoni protein kinase 0.0241 0.1794 0.2736
Echinococcus multilocularis casein kinase I alpha 0.0066 0.0266 0.0322
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.134 0.2044
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0169 0.1166 0.1412
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0195 0.0835
Schistosoma mansoni cell adhesion molecule 0.0044 0.0081 0.0124
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0045 0.0086 0.0308
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Brugia malayi p70 ribosomal S6 kinase beta 0.0297 0.2284 0.2477
Loa Loa (eye worm) hypothetical protein 0.0117 0.0711 0.0772
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.0861 0.3679
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0161 0.11 0.1193
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0257 0.1935 0.2342
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase domain containing protein 0.004 0.0047 0.0203
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0154 0.1034 0.899
Loa Loa (eye worm) TK protein kinase 0.0106 0.0617 0.067
Brugia malayi Tyrosine-protein kinase abl-1 0.0151 0.1013 0.1099
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0041 0.0057 0.0109
Onchocerca volvulus 0.0037 0.0015 0.0028
Schistosoma mansoni tyrosine kinase 0.0458 0.3683 0.5619
Loa Loa (eye worm) RasGEF domain-containing protein 0.0052 0.0148 0.0161
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0066 0.0266 0.0323
Echinococcus granulosus rho-associated protein kinase 1 0.0366 0.288 0.288
Entamoeba histolytica tyrosin kinase, putative 0.004 0.0047 0.0203
Echinococcus multilocularis Immunoglobulin 0.0089 0.0474 0.0574
Entamoeba histolytica serine/threonine kinase, putative 0.0037 0.0015 0.0063
Echinococcus granulosus activin receptor type 0.0057 0.0195 0.0195
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0294 0.2255 0.2445
Echinococcus granulosus tyrosine protein kinase Lyn 0.019 0.1347 0.1347
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0044 0.0081 0.0088
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0126 0.0795 0.3389
Brugia malayi Protein kinase domain containing protein 0.0071 0.0318 0.0345
Toxoplasma gondii diacylglycerol kinase, putative 0.0052 0.0148 0.0589
Echinococcus multilocularis mitogen activated protein kinase 0.0081 0.0399 0.0483
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0037 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0315 0.2439 0.2645
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Trypanosoma brucei protein kinase, putative 0.0057 0.0195 0.0777
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0081 0.0399 0.1694
Brugia malayi C1-like domain containing protein 0.0169 0.1168 0.1267
Echinococcus multilocularis calcium activated potassium channel 0.0093 0.0506 0.0612
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0066 0.0266 0.0289
Schistosoma mansoni protein tyrosine kinase 0.0037 0.0015 0.0023
Entamoeba histolytica protein kinase, putative 0.0078 0.0376 0.1606
Schistosoma mansoni microsomal glutathione s-transferase 0.0135 0.0872 0.133
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Echinococcus multilocularis tyrosine protein kinase shark 0.0071 0.0318 0.0385
Onchocerca volvulus 0.0071 0.0318 0.0614
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0015 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Echinococcus multilocularis N chimaerin 0.0087 0.0453 0.0548
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0037 0.0015 0.0028
Echinococcus multilocularis Diacylglycerol kinase theta 0.0052 0.0148 0.018
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.011
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0146 0.0968 0.0968
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0301 0.2316 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0124 0.0779 0.0779
Trypanosoma brucei casein kinase I, isoform 2 0.0066 0.0266 0.1082
Brugia malayi Protein kinase domain containing protein 0.0078 0.0376 0.0408
Loa Loa (eye worm) hypothetical protein 0.0071 0.0318 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.011 0.0409
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0117 0.0711 0.0772
Leishmania major protein kinase A catalytic subunit 0.0068 0.0289 0.119
Schistosoma mansoni hypothetical protein 0.0037 0.0019 0.0029
Echinococcus multilocularis protein KINase family member (kin 25) 0.0037 0.0015 0.0018
Echinococcus multilocularis transfer RNA-Thr 0.0037 0.0015 0.0018
Echinococcus multilocularis NCK adaptor protein 0.0063 0.0245 0.0297
Brugia malayi Serine/threonine-protein kinase Pim-3 0.021 0.152 0.1648
Echinococcus multilocularis serine:threonine protein kinase 0.0117 0.0711 0.0861
Echinococcus multilocularis protein kinase 0.0037 0.0015 0.0018
Echinococcus multilocularis tyrosine protein kinase Abl 0.0193 0.1379 0.1669
Echinococcus granulosus PAK box P21 Rho binding 0.0037 0.0019 0.0019
Schistosoma mansoni protein kinase C mu 0.0169 0.1168 0.1782
Schistosoma mansoni protein kinase 0.0037 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0063 0.0242 0.0262
Echinococcus granulosus microtubule associated protein 2 0.0788 0.6555 0.6555
Toxoplasma gondii AGC kinase 0.0068 0.0289 0.1208
Loa Loa (eye worm) CAMK/PIM protein kinase 0.021 0.152 0.1648
Entamoeba histolytica protein kinase, putative 0.0066 0.0267 0.1139
Echinococcus granulosus serine:threonine protein kinase 0.0117 0.0711 0.0711
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0015 0.0018
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Giardia lamblia Kinase, AGC PKA 0.0068 0.0289 0.119
Entamoeba histolytica serine/threonine protein kinase, putative 0.0047 0.0109 0.0467
Loa Loa (eye worm) hypothetical protein 0.0106 0.0614 0.0666
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Brugia malayi SH2 domain containing protein 0.0071 0.0318 0.0345
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.0015 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.011 0.0168
Brugia malayi protein-tyrosine kinase 0.0141 0.0921 0.0999
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Echinococcus multilocularis roundabout 2 0.0134 0.0859 0.104
Brugia malayi Stress-activated protein kinase jnk-1 0.0294 0.2255 0.2445
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0037 0.0015 0.0016
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0289 0.119
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0423 0.0423
Schistosoma mansoni protein kinase 0.0241 0.1794 0.2736
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0154 0.1034 0.4418
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0376 0.1553
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0241 0.1794 0.2172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0135 0.0872 0.1056
Onchocerca volvulus 0.0071 0.0318 0.0614
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.021 0.152 0.2934
Entamoeba histolytica protein kinase, putative 0.0297 0.2284 0.9758
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0141 0.0919 0.0997
Schistosoma mansoni protein kinase C mu 0.0052 0.0148 0.0226
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0169 0.1168 0.1267
Onchocerca volvulus 0.0076 0.0355 0.0685
Loa Loa (eye worm) CAMK protein kinase 0.0043 0.0074 0.008
Entamoeba histolytica protein kinase, putative 0.0049 0.0123 0.0525
Echinococcus granulosus mitogen activated protein kinase 11 0.017 0.1174 0.1174
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0141 0.0921 0.0921
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0035 0.0001 0.0001
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0095 0.052 0.052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0057 0.0061
Entamoeba histolytica protein kinase, putative 0.0126 0.0795 0.3397
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0294 0.2255 0.273
Entamoeba histolytica cell division protein kinase 2, putative 0.0122 0.076 0.3246
Brugia malayi Protein kinase domain containing protein 0.0122 0.076 0.0824
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0081 0.0088
Trichomonas vaginalis CK1 family protein kinase 0.0066 0.0266 0.1082
Plasmodium falciparum casein kinase 2, alpha subunit 0.01 0.0567 0.4876
Echinococcus multilocularis tyrosine kinase 0.0071 0.0318 0.0385
Loa Loa (eye worm) AUR protein kinase 0.0154 0.1034 0.1121
Brugia malayi phosphoinositide-dependent protein kinase I 0.0078 0.0376 0.0408
Entamoeba histolytica cysteine surface protein, putative 0.0037 0.0015 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0938 0.397
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Echinococcus multilocularis tyrosine protein kinase 0.0037 0.0015 0.0018
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.0015 0.0018
Schistosoma mansoni growth factor receptor-bound protein 0.0063 0.0245 0.0374
Schistosoma mansoni serine/threonine-protein kinase 0.0173 0.1205 0.1838
Loa Loa (eye worm) TK/FAK protein kinase 0.0037 0.0015 0.0016
Onchocerca volvulus 0.0066 0.0266 0.0514
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0083 0.0423 0.0512
Loa Loa (eye worm) hypothetical protein 0.0096 0.0535 0.0581
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0289 0.044
Echinococcus multilocularis mitogen activated protein kinase 14 0.017 0.1174 0.1422
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.0073
Schistosoma mansoni growth factor receptor-bound protein 0.0063 0.0245 0.0374
Echinococcus granulosus dnaJ subfamily B 0.0467 0.3761 0.3761
Echinococcus multilocularis geminin 0.0194 0.1381 0.1672
Echinococcus multilocularis tyrosine protein kinase otk 0.0041 0.0057 0.0069
Schistosoma mansoni hypothetical protein 0.0095 0.052 0.0793
Echinococcus multilocularis tyrosine protein kinase Blk 0.0141 0.0921 0.1115
Giardia lamblia Kinase, CAMK CAMKL 0.0047 0.0109 0.0411
Loa Loa (eye worm) hypothetical protein 0.0076 0.0355 0.0385
Brugia malayi diacylglycerol kinase 0.0052 0.0148 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.0301 0.2316 1
Schistosoma mansoni vesicular amine transporter 0.0089 0.0474 0.0723
Echinococcus granulosus tyrosine protein kinase pr2 0.0037 0.0015 0.0015
Brugia malayi casein kinase 1, delta 0.0066 0.0266 0.0289
Schistosoma mansoni protein kinase 0.0057 0.0195 0.0298
Echinococcus granulosus casein kinase I delta 0.0066 0.0266 0.0266
Echinococcus multilocularis mitogen activated protein kinase 11 0.017 0.1174 0.1422
Brugia malayi serine/threonine-protein kinase PAK 7 0.0256 0.1924 0.2087
Loa Loa (eye worm) hypothetical protein 0.0089 0.0474 0.0514
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Echinococcus granulosus protein kinase c iota type 0.0301 0.2316 0.2316
Loa Loa (eye worm) raf kinase 0.0052 0.0148 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.0301 0.2316 1
Echinococcus granulosus tyrosine kinase 0.0141 0.0921 0.0921
Brugia malayi Furin-like cysteine rich region family protein 0.0704 0.5822 0.6315
Schistosoma mansoni adapter molecule crk 0.0063 0.0245 0.0374
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) TK/ACK protein kinase 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0057 0.0061
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0104 0.0603 0.073
Schistosoma mansoni serine/threonine protein kinase 0.0448 0.359 0.5477
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0169 0.1166 0.1412
Entamoeba histolytica hypothetical protein 0.0037 0.0019 0.0081
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0048 0.011 0.011
Loa Loa (eye worm) TK/Met protein kinase 0.0037 0.0015 0.0016
Toxoplasma gondii AGC kinase 0.0297 0.2284 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1012 0.1545
Plasmodium vivax casein kinase 1, putative 0.0066 0.0266 0.2219
Echinococcus multilocularis roundabout 2 0.0044 0.0081 0.0098
Brugia malayi Cytochrome P450 family protein 0.0036 0.0008 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0151 0.1012 0.429
Echinococcus granulosus natriuretic peptide receptor 1 0.0037 0.0015 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0131 0.0837 0.3538
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.0133
Echinococcus multilocularis Immunoglobulin 0.0089 0.0474 0.0574
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0068 0.0289 0.1178
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.0711 0.2996
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1012 0.1545
Echinococcus multilocularis tyrosine protein kinase pr2 0.0037 0.0015 0.0018
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0219 0.1602 0.1602
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.011 0.011
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0122 0.076 0.076
Toxoplasma gondii casein kinase I 0.0066 0.0266 0.1109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Onchocerca volvulus 0.0134 0.0861 0.1662
Echinococcus granulosus protein kinase 0.0037 0.0015 0.0015
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0087 0.0453 0.0491
Loa Loa (eye worm) AGC/AKT protein kinase 0.0304 0.234 0.2538
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0063 0.0245 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0399 0.1653
Brugia malayi hypothetical protein 0.0092 0.0499 0.0541
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0081 0.0399 0.0433
Brugia malayi Protein kinase domain containing protein 0.0071 0.0318 0.0345
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0087 0.0452 0.0452
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0241 0.1794 0.1794
Trypanosoma brucei rac serine-threonine kinase, putative 0.0304 0.234 1
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0467 0.0712
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.0187 0.0226
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0048 0.011 0.0839
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0037 0.0019 0.0029
Echinococcus granulosus NDR protein kinase 0.0151 0.1012 0.1012
Entamoeba histolytica hypothetical protein 0.0037 0.0019 0.0081
Loa Loa (eye worm) hypothetical protein 0.009 0.0476 0.0516
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0047 0.0109 0.0411
Echinococcus granulosus serine/threonine protein kinase 0.0173 0.1205 0.1205
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0151 0.1012 0.1012
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0376 0.1553
Schistosoma mansoni protein kinase 0.0048 0.011 0.0168
Loa Loa (eye worm) hypothetical protein 0.0099 0.0556 0.0603
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0289 0.2417
Echinococcus multilocularis activin receptor type 0.0057 0.0195 0.0237
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.0073
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Echinococcus granulosus serine:threonine protein kinase 0.0117 0.0711 0.0711
Plasmodium falciparum calcium-dependent protein kinase 1 0.0048 0.011 0.0839
Echinococcus multilocularis growth factor receptor bound protein 2 0.0063 0.0245 0.0297
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0058 0.0205 0.0222
Brugia malayi Protein kinase domain containing protein 0.0071 0.0318 0.0345
Brugia malayi P21-Rho-binding domain containing protein 0.0037 0.0019 0.0021
Entamoeba histolytica protein kinase, putative 0.0151 0.1012 0.4326
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.0015 0.0023
Onchocerca volvulus 0.0045 0.0086 0.0165
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0068 0.0289 0.0313
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0057 0.0061
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0134 0.0861 0.0934
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0173 0.1205 0.5171
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0219 0.1602 0.1737
Brugia malayi WH1 domain containing protein 0.0037 0.0019 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0301 0.2316 0.9898
Brugia malayi P21-Rho-binding domain containing protein 0.0037 0.0019 0.0021
Onchocerca volvulus 0.0366 0.288 0.5561
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1012 0.1545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0057 0.0061
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0161 0.11 0.1193
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0053 0.0161 0.0195
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.0015 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis Glutaredoxin protein 5 0.0146 0.0968 0.1172
Echinococcus granulosus cyclin dependent kinase 5 0.0122 0.076 0.076
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0056 0.0181 0.0772
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis peroxidasin 0.0042 0.0059 0.0071
Echinococcus granulosus tyrosine protein kinase Src42A 0.0104 0.0603 0.0603
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0135 0.0872 0.133
Loa Loa (eye worm) hypothetical protein 0.0164 0.1123 0.1218
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Brugia malayi Protein kinase domain containing protein 0.0093 0.0506 0.0548
Giardia lamblia Kinase, CMGC CDK 0.0122 0.076 0.3236
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0143 0.0939 0.1136
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0082 0.0409 0.1694
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Entamoeba histolytica casein kinase, putative 0.01 0.0567 0.2425
Schistosoma mansoni serine/threonine-protein kinase 0.0173 0.1205 0.1838
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0153 0.1027 0.1027
Loa Loa (eye worm) TK/ABL protein kinase 0.0317 0.245 0.2657
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.035
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Schistosoma mansoni cell adhesion molecule 0.0044 0.0081 0.0124
Brugia malayi Protein kinase domain containing protein 0.0117 0.0711 0.0772
Echinococcus granulosus casein kinase i 0.0066 0.0266 0.0266
Loa Loa (eye worm) apoptosis regulator protein 0.0095 0.052 0.0563
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0134 0.0861 0.1314
Onchocerca volvulus 0.0037 0.0015 0.0028
Trypanosoma brucei protein kinase, putative 0.0134 0.0861 0.3639
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0048 0.011 0.0409
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0081 0.0399 0.167
Schistosoma mansoni kinase 0.0323 0.2506 0.3823
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.021 0.152 0.2319
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0317 0.245 0.2967
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0267 0.0407
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Plasmodium falciparum serine/threonine protein kinase KIN 0.0047 0.0109 0.0834
Brugia malayi bone morphogenetic protein type 1 receptor 0.0037 0.0015 0.0016
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0041 0.0057 0.0069
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Brugia malayi RhoGAP domain containing protein 0.0087 0.0453 0.0491
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0318 0.0345
Echinococcus granulosus serine:threonine protein kinase 3 0.0285 0.2178 0.2178
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0134 0.0861 0.0934
Echinococcus multilocularis casein kinase ii subunit alpha 0.01 0.0567 0.0687
Schistosoma mansoni hypothetical protein 0.0037 0.0019 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.076 0.3203
Schistosoma mansoni titin 0.0041 0.0057 0.0086
Schistosoma mansoni serine/threonine kinase 0.0093 0.0506 0.0771
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.007 0.0075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.0921 0.1115
Echinococcus granulosus tyrosine protein kinase Blk 0.0141 0.0921 0.0921
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0122 0.076 0.3236
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0044 0.0081 0.0098
Echinococcus granulosus raf serine:threonine protein kinase 0.0089 0.0467 0.0467
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Brugia malayi Protein kinase domain containing protein 0.0126 0.0795 0.0862
Loa Loa (eye worm) hypothetical protein 0.0164 0.1123 0.1218
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0134 0.0861 0.1043
Echinococcus multilocularis casein kinase I delta 0.0066 0.0266 0.0322
Echinococcus granulosus Diacylglycerol kinase theta 0.0052 0.0148 0.0148
Brugia malayi Fibronectin type III domain containing protein 0.0092 0.0499 0.0541
Loa Loa (eye worm) TK/EGFR protein kinase 0.0704 0.5822 0.6315
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0109 0.0167
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0154 0.1034 0.1252
Echinococcus granulosus casein kinase ii subunit alpha 0.01 0.0567 0.0567
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0037 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0071 0.0318 0.0385
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0044 0.0081 0.0081
Schistosoma mansoni roundabout 0.0041 0.0057 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0399 0.0609
Schistosoma mansoni protein kinase 0.0066 0.0266 0.0406
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.0015 0.0015
Echinococcus multilocularis PAK box P21 Rho binding 0.0037 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.017 0.1172 0.1271
Echinococcus multilocularis neuroglian 0.0044 0.0081 0.0098
Echinococcus granulosus c src tyrosine kinase 0.01 0.0564 0.0564
Echinococcus multilocularis protein kinase 0.0037 0.0015 0.0018
Onchocerca volvulus Tyrosine kinase homolog 0.063 0.5179 1
Entamoeba histolytica protein kinase , putative 0.0154 0.1034 0.4418
Plasmodium falciparum casein kinase 1 0.0066 0.0266 0.2219
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Echinococcus multilocularis RNA directed DNA polymerase 0.0047 0.0104 0.0126
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0046 0.01 0.0371
Trypanosoma cruzi aurora B kinase, putative 0.0154 0.1034 0.4427
Entamoeba histolytica protein kinase, putative 0.0037 0.0015 0.0063
Loa Loa (eye worm) serine/threonine protein kinase 0.0037 0.0015 0.0016
Brugia malayi Protein kinase domain containing protein 0.0213 0.1552 0.1683
Echinococcus granulosus tyrosine kinase 0.0037 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0155 0.1044 0.1132
Trichomonas vaginalis STE family protein kinase 0.0082 0.0409 0.1694
Schistosoma mansoni tyrosine kinase 0.0422 0.3364 0.5133
Plasmodium falciparum protein kinase 5 0.0122 0.076 0.6571
Onchocerca volvulus 0.0053 0.0161 0.0312
Loa Loa (eye worm) TK protein kinase 0.0291 0.2224 0.2413
Schistosoma mansoni vav2 0.0093 0.0508 0.0776
Brugia malayi serine/threonine-protein kinase plk-2 0.0301 0.2316 0.2512
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0289 0.119
Plasmodium falciparum serine/threonine protein kinase, putative 0.0154 0.1034 0.899
Onchocerca volvulus 0.0096 0.0535 0.1034
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0109 0.0167
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0046 0.01 0.0109
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0178 0.1244 0.1349
Brugia malayi Prion-like- 0.0041 0.0057 0.0061
Echinococcus granulosus titin 0.0043 0.0074 0.0074
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Brugia malayi serine/threonine kinase 12 0.0154 0.1034 0.1121
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.0187 0.0187
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0037 0.0019 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Plasmodium falciparum calcium-dependent protein kinase 3 0.0048 0.011 0.0839
Echinococcus granulosus protein kinase c eta type 0.0052 0.0148 0.0148
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0035 0.0001 0.0001
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0122 0.076 0.3236
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0148 0.0987 0.1071
Giardia lamblia Kinase, CAMK CAMKL 0.0047 0.0109 0.0411
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0151 0.1012 0.1098
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0037 0.0015 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0567 0.2377
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0052 0.0148 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.1877 0.2864
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.2316 0.3534
Echinococcus granulosus fibroblast growth factor receptor 4 0.0271 0.2053 0.2053
Loa Loa (eye worm) hypothetical protein 0.0092 0.0499 0.0541
Schistosoma mansoni hypothetical protein 0.0072 0.0325 0.0496
Echinococcus multilocularis serine:threonine protein kinase 38 0.0151 0.1012 0.1226
Echinococcus granulosus Glutaredoxin protein 5 0.0146 0.0968 0.0968
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0515 0.4176 0.4176
Echinococcus multilocularis protein kinase c epsilon type 0.0205 0.1477 0.1789
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.021 0.152 0.184
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0122 0.076 0.0824
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0095 0.052 0.052
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.1885 0.2876
Toxoplasma gondii MAPEG family protein 0.0135 0.0872 0.3778
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.0289
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Echinococcus granulosus defective proboscis extension response 0.0089 0.0474 0.0474
Leishmania major protein kinase, putative 0.0057 0.0195 0.0785
Schistosoma mansoni serine/threonine protein kinase 0.0366 0.288 0.4394
Entamoeba histolytica serine/threonine protein kinase, putative 0.0301 0.2316 0.9899
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0047 0.0108 0.0131
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0169 0.1166 0.1412
Schistosoma mansoni tyrosine kinase 0.0512 0.4151 0.6334
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.003 0.0032
Trypanosoma cruzi cdc2-related kinase 1 0.0122 0.076 0.3236
Leishmania major casein kinase II, putative 0.01 0.0567 0.2401
Schistosoma mansoni ephrin receptor 0.0112 0.0673 0.1026
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0271 0.2053 0.2053
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0458 0.3683 0.3683
Trichomonas vaginalis STE family protein kinase 0.0058 0.02 0.0795
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0037 0.0015 0.0016
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Schistosoma mansoni protein kinase 0.0037 0.0015 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0304 0.234 1
Echinococcus multilocularis protein kinase c iota type 0.0301 0.2316 0.2805
Echinococcus multilocularis mitogen activated protein kinase 3 0.0081 0.0399 0.0483
Giardia lamblia Kinase, NEK 0.0143 0.0938 0.401
Echinococcus multilocularis rho associated protein kinase 0.0366 0.288 0.3488
Echinococcus multilocularis casein kinase I delta 0.0066 0.0266 0.0322
Onchocerca volvulus 0.0345 0.27 0.5212
Schistosoma mansoni hypothetical protein 0.0052 0.0148 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Onchocerca volvulus 0.0071 0.0318 0.0614
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0048 0.011 0.0419
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0289 0.1178
Entamoeba histolytica ankyrin repeat protein 0.0037 0.0015 0.0063
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0047 0.0109 0.0407
Schistosoma mansoni titin 0.0043 0.0074 0.0113
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Giardia lamblia Kinase, CMGC MAPK 0.0081 0.0399 0.167
Brugia malayi RhoGEF domain containing protein 0.0052 0.0148 0.0161
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0189 0.134 0.1622
Schistosoma mansoni apoptosis regulator bax 0.0095 0.052 0.0793
Brugia malayi SH2 domain containing protein 0.0071 0.0318 0.0345
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0161
Brugia malayi Kinase associated domain 1 family protein 0.0072 0.0325 0.0352
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0043 0.0074 0.008
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0095 0.052 0.0793
Brugia malayi ephrin receptor 1 precursor 0.0072 0.0325 0.0352
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0087 0.0453 0.0691
Echinococcus granulosus epidermal growth factor receptor 0.0458 0.3683 0.3683
Echinococcus multilocularis activated cdc42 kinase 1 0.0037 0.0015 0.0018
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0087 0.0453 0.0691
Giardia lamblia Kinase, CMGC GSK 0.0134 0.0861 0.3677
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0016
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0289 0.119
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.1885 0.2876
Schistosoma mansoni protein kinase 0.0154 0.1034 0.1577
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0257 0.1935 0.1935
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0582 0.0889
Entamoeba histolytica protein kinase, putative 0.0126 0.0795 0.3397
Schistosoma mansoni tyrosine kinase 0.0704 0.5822 0.8883
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.035
Echinococcus multilocularis tyrosine kinase 0.0037 0.0015 0.0018
Echinococcus multilocularis myotubularin protein 13 0.0058 0.0205 0.0248
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0063
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0289 0.0313
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.0407
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0081 0.0088
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0861 0.3639
Echinococcus multilocularis roundabout 2 0.0044 0.0081 0.0098
Loa Loa (eye worm) hypothetical protein 0.0063 0.0245 0.0266
Trichomonas vaginalis AGC family protein kinase 0.0158 0.1069 0.4534
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.01 0.0564 0.086
Echinococcus granulosus RNA directed DNA polymerase 0.0047 0.0104 0.0104
Echinococcus granulosus tyrosine protein kinase Fyn 0.0169 0.1166 0.1166
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0506 0.0771
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0015 0.0063
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0048 0.011 0.0419
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0289 0.0313
Echinococcus granulosus c-Jun N-terminal kinases 0.0294 0.2255 0.2255
Trypanosoma cruzi cdc2-related kinase 1 0.0122 0.076 0.3236
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0015 0.0015
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.017 0.1174 0.1273
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Giardia lamblia Kinase, STE STE20 0.0082 0.0409 0.1711
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0047 0.0109 0.0411
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Giardia lamblia Kinase, AGC PKA 0.0167 0.1148 0.4925
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0134 0.0861 0.0861
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0015 0.0016
Echinococcus granulosus aurora kinase A 0.0154 0.1034 0.1034
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0251 0.1877 0.2036
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0069 0.0298 0.0323
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.0289
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0126 0.0795 0.0862
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0048 0.011 0.0119
Loa Loa (eye worm) hypothetical protein 0.0073 0.0327 0.0355
Entamoeba histolytica protein kinase, putative 0.0083 0.0423 0.1806
Schistosoma mansoni nephrin 0.0112 0.0671 0.1023
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0126 0.0795 0.3355
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Trypanosoma cruzi casein kinase, putative 0.0066 0.0266 0.1093
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0448 0.359 0.4347
Echinococcus granulosus unc 13 munc13 0.0053 0.0161 0.0161
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0189 0.134 0.134
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0057 0.0061
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0047 0.0109 0.0119
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Schistosoma mansoni tyrosine kinase 0.0074 0.0337 0.0514
Trypanosoma brucei SNF1-related protein kinases, putative 0.0047 0.0109 0.0407
Echinococcus multilocularis aurora kinase A 0.0154 0.1034 0.1252
Entamoeba histolytica receptor protein kinase, putative 0.0037 0.0015 0.0063
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Brugia malayi Variant SH3 domain containing protein 0.0043 0.007 0.0075
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0289 0.1178
Echinococcus granulosus myotubularin protein 13 0.0058 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0095 0.052 0.0793
Brugia malayi intracellular kinase 0.0134 0.0861 0.0934
Brugia malayi Protein kinase domain containing protein 0.0071 0.0318 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0939 0.1432
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0082 0.0409 0.1711
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0167 0.1148 0.1148
Schistosoma mansoni tyrosine kinase 0.0071 0.0318 0.0485
Brugia malayi Casein kinase II, alpha chain 0.01 0.0567 0.0615
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Echinococcus multilocularis microtubule associated protein 2 0.0788 0.6555 0.7937
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0046 0.01 0.0109
Echinococcus granulosus casein kinase I delta 0.0066 0.0266 0.0266
Brugia malayi Protein kinase domain containing protein 0.0219 0.1602 0.1737
Trypanosoma brucei Casein kinase II 0.01 0.0567 0.2377
Brugia malayi Protein kinase domain containing protein 0.0071 0.0318 0.0345
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0122 0.076 0.0824
Giardia lamblia Kinase, AGC AKT 0.012 0.0742 0.3159
Brugia malayi Protein kinase domain containing protein 0.0037 0.0015 0.0016
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0289 0.035
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0071 0.0318 0.0318
Brugia malayi Peroxidasin 0.0042 0.0059 0.0064
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0048 0.011 0.0119
Leishmania major protein kinase A catalytic subunit isoform 1 0.0068 0.0289 0.119
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0126 0.0795 0.3389
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0074 0.0113
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0161 0.0246
Entamoeba histolytica tyrosine kinase, putative 0.0037 0.0015 0.0063
Plasmodium falciparum calcium-dependent protein kinase 4 0.0048 0.011 0.0839
Loa Loa (eye worm) AUR protein kinase 0.0154 0.1034 0.1121
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.1477 0.2254
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0089 0.0474 0.0723
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0111 0.0662 0.0662
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.017 0.1174 0.5037
Brugia malayi Receptor family ligand binding region containing protein 0.0037 0.0015 0.0016
Brugia malayi Tyrosine-protein kinase PR2 0.0037 0.0015 0.0016
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0037 0.0015 0.0016
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0037 0.0015 0.0063
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0083 0.0423 0.0423
Onchocerca volvulus 0.0037 0.0015 0.0028
Schistosoma mansoni tyrosine kinase 0.0037 0.0015 0.0023
Schistosoma mansoni hypothetical protein 0.0037 0.0015 0.0023

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) Inhibition of CYP2C19 ChEMBL. 19739647
IC50 (ADMET) Inhibition of CYP1A2 ChEMBL. 19739647
IC50 (ADMET) = 2.6 nM Inhibition of CYP2D6 ChEMBL. 19739647
IC50 (ADMET) = 4.7 nM Inhibition of CYP3A4 ChEMBL. 19739647
IC50 (binding) = 9 nM Displacement of [3H]3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzyl-indol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear cell membrane ChEMBL. 19739647
IC50 (ADMET) = 15.5 nM Inhibition of CYP2C9 ChEMBL. 19739647

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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