Detailed information for compound 1041814

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.896 | Formula: C22H23ClN4O3
  • H donors: 1 H acceptors: 3 LogP: 4.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(/C(=N\O)/c1cccnc1Oc1ccc(cc1c1ccno1)Cl)CC1CC1
  • InChi: 1S/C22H23ClN4O3/c1-2-12-27(14-15-5-6-15)21(26-28)17-4-3-10-24-22(17)29-19-8-7-16(23)13-18(19)20-9-11-25-30-20/h3-4,7-11,13,15,28H,2,5-6,12,14H2,1H3/b26-21-
  • InChiKey: PYJLDYBOGDGUEZ-QLYXXIJNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Toxoplasma gondii flavodoxin domain-containing protein 0.0024 0.001 0.001
Echinococcus multilocularis beta tubulin 0.2156 1 1
Brugia malayi alpha-tubulin 0.1616 0.747 0.747
Loa Loa (eye worm) tubulin alpha-2 chain 0.1616 0.747 0.747
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0655 0.2967 0.2953
Leishmania major beta tubulin 0.2156 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0075 0.0075
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.019 0.0171
Giardia lamblia Gamma tubulin 0.132 0.6083 0.6045
Onchocerca volvulus 0.0056 0.016 0.0478
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0075 0.0075
Leishmania major beta tubulin 0.2156 1 1
Leishmania major beta tubulin 0.2156 1 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.021 0.021
Echinococcus granulosus Chromobox protein 3 0.0026 0.0019 0.0019
Echinococcus granulosus Tubulin beta 2C chain 0.2156 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0388 0.0388
Leishmania major beta tubulin 0.2156 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0214 0.0214
Trichomonas vaginalis tubulin beta chain, putative 0.1616 0.747 0.7466
Loa Loa (eye worm) acetyltransferase 0.0289 0.1254 0.1254
Trypanosoma brucei alpha tubulin 0.1616 0.747 0.747
Trichomonas vaginalis chromobox protein, putative 0.0156 0.0631 0.0613
Echinococcus multilocularis tubulin alpha 3 chain 0.1616 0.747 0.747
Leishmania major alpha tubulin 0.1616 0.747 0.747
Leishmania major beta tubulin 0.2156 1 1
Schistosoma mansoni inositol transporter 0.004 0.0087 0.0087
Leishmania major alpha tubulin 0.1616 0.747 0.747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Trypanosoma brucei tubulin delta chain 0.1241 0.5716 0.5716
Loa Loa (eye worm) tubulin beta chain 0.0554 0.2494 0.2494
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0211 0.0211
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0019 0.0019
Trypanosoma cruzi tubulin delta chain 0.1241 0.5716 0.5716
Brugia malayi MAP kinase sur-1 0.0104 0.0388 0.0388
Schistosoma mansoni hypothetical protein 0.0026 0.0019 0.0019
Echinococcus granulosus tar DNA binding protein 0.0066 0.021 0.021
Trypanosoma brucei alpha tubulin 0.1616 0.747 0.747
Brugia malayi GH02984p 0.0363 0.1602 0.1602
Brugia malayi acetyltransferase, GNAT family protein 0.0289 0.1254 0.1254
Brugia malayi Tubulin gamma chain 0.132 0.6083 0.6083
Loa Loa (eye worm) PHD-finger family protein 0.0067 0.0211 0.0211
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0061 0.0042
Brugia malayi Bromodomain containing protein 0.0076 0.0255 0.0255
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0155 0.0155
Echinococcus granulosus beta tubulin 0.2156 1 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0066 0.021 0.021
Leishmania major beta tubulin 0.2156 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.1616 0.747 0.747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.004 0.004
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0133 0.052 0.052
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0048 0.0123 0.0123
Trypanosoma brucei alpha tubulin, putative 0.0655 0.2967 0.2967
Trichomonas vaginalis tubulin gamma chain, putative 0.1318 0.6076 0.6068
Schistosoma mansoni tar DNA-binding protein 0.0066 0.021 0.021
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0075 0.0075
Trichomonas vaginalis tubulin, putative 0.0655 0.2967 0.2953
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0087 0.0087
Plasmodium vivax tubulin gamma chain, putative 0.132 0.6083 0.6083
Trypanosoma cruzi beta tubulin, putative 0.2156 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.1616 0.747 0.747
Giardia lamblia Epsilon tubulin 0.0664 0.3008 0.294
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Schistosoma mansoni high-affinity choline transporter 0.0363 0.1602 0.1602
Schistosoma mansoni bromodomain containing protein 0.0071 0.0231 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0123 0.0123
Loa Loa (eye worm) tubulin alpha chain 0.1616 0.747 0.747
Trypanosoma brucei epsilon tubulin 0.1318 0.6076 0.6076
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0075 0.0075
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0075 0.0075
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0075 0.0075
Leishmania major beta tubulin 0.2156 1 1
Leishmania major epsilon tubulin, putative 0.1318 0.6076 0.6076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0075 0.0075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0305 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0388 0.037
Brugia malayi Cell division protein ftsZ 0.0554 0.2494 0.2494
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0133 0.052 0.052
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0075 0.0075
Trichomonas vaginalis tubulin beta chain, putative 0.1616 0.747 0.7466
Loa Loa (eye worm) hypothetical protein 0.0047 0.012 0.012
Schistosoma mansoni tubulin subunit beta 0.2156 1 1
Loa Loa (eye worm) BEN-1 protein 0.2156 1 1
Plasmodium vivax flavodoxin domain containing protein 0.0042 0.0097 0.0097
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0124 0.0124
Schistosoma mansoni chromobox protein 0.0156 0.0631 0.0631
Plasmodium falciparum tubulin epsilon chain, putative 0.1318 0.6076 0.6076
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0133 0.052 0.052
Echinococcus multilocularis Tubulin alpha 1 chain 0.1616 0.747 0.747
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0001 0.0001
Plasmodium vivax tubulin beta chain, putative 0.2156 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0388 0.0388
Loa Loa (eye worm) RNA binding protein 0.0066 0.021 0.021
Echinococcus granulosus tubulin alpha 1C chain 0.1616 0.747 0.747
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0388 0.0388
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0075 0.0075
Onchocerca volvulus 0.004 0.0087 0.0231
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0124 0.0124
Leishmania major zeta tubulin, putative 0.1703 0.788 0.788
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0075 0.0075
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0261 0.0166
Loa Loa (eye worm) tubulin beta-2A chain 0.2156 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0093 0.0334 0.0334
Echinococcus granulosus tubulin alpha chain 0.1616 0.747 0.747
Echinococcus granulosus tubulin alpha 1C chain 0.1616 0.747 0.747
Trichomonas vaginalis tubulin beta chain, putative 0.1616 0.747 0.7466
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0048 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0323 0.1413 0.1413
Echinococcus multilocularis tubulin alpha chain 0.1616 0.747 0.747
Leishmania major beta tubulin 0.2156 1 1
Loa Loa (eye worm) tubulin alpha 2 0.1062 0.4875 0.4875
Schistosoma mansoni tubulin subunit alpha 0.1616 0.747 0.747
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Echinococcus multilocularis tubulin alpha 1C chain 0.1616 0.747 0.747
Echinococcus multilocularis chromobox protein 2 0.0026 0.0019 0.0019
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1241 0.5716 0.5716
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0075 0.0075
Brugia malayi Bromodomain containing protein 0.0082 0.0286 0.0286
Echinococcus multilocularis peroxisome assembly protein 26 0.1616 0.747 0.747
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0133 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0123 0.0123
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0066 0.021 0.021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0075 0.0075
Echinococcus multilocularis tubulin subunit TubB 0.1616 0.747 0.747
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0075 0.0075
Giardia lamblia Beta tubulin 0.2156 1 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0049 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0088 0.0088
Brugia malayi Bromodomain containing protein 0.0046 0.0113 0.0113
Trypanosoma brucei beta tubulin 0.2156 1 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0029 0.0037 0.0037
Plasmodium falciparum tubulin gamma chain 0.132 0.6083 0.6083
Echinococcus granulosus methionine synthase reductase 0.0029 0.0037 0.0037
Echinococcus multilocularis tubulin beta 1 chain 0.2156 1 1
Leishmania major beta tubulin 0.2156 1 1
Mycobacterium ulcerans cell division protein FtsZ 0.0554 0.2494 1
Loa Loa (eye worm) tubulin beta chain 0.2156 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0211 0.0211
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0305 0.0287
Echinococcus multilocularis tubulin alpha chain 0.1616 0.747 0.747
Schistosoma mansoni tubulin subunit alpha 0.1616 0.747 0.747
Trypanosoma brucei beta tubulin 0.2156 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0961 0.4403 0.4392
Echinococcus multilocularis tubulin alpha chain 0.1616 0.747 0.747
Echinococcus granulosus Tubulin beta 2C chain 0.2156 1 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0026 0.0019 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0075 0.0075
Echinococcus granulosus tubulin alpha 0.1208 0.5562 0.5562
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0305 0.0305
Echinococcus granulosus tubulin epsilon chain 0.1318 0.6076 0.6076
Schistosoma mansoni tubulin subunit beta 0.2156 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0075 0.0075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0286 0.0286
Echinococcus multilocularis tubulin alpha chain 0.1616 0.747 0.747
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0029 0.0037 0.0037
Onchocerca volvulus Alhambra homolog 0.0067 0.0211 0.0653
Trypanosoma cruzi zeta tubulin, putative 0.1703 0.788 0.788
Plasmodium falciparum tubulin delta chain, putative 0.0554 0.2494 0.2494
Loa Loa (eye worm) hypothetical protein 0.0069 0.0221 0.0221
Echinococcus multilocularis chromobox protein 1 0.0156 0.0631 0.0631
Brugia malayi mbt repeat family protein 0.0048 0.0124 0.0124
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0042 0.0097 0.0078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0075 0.0075
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0261 0.0243
Trichomonas vaginalis tubulin epsilon chain, putative 0.1616 0.747 0.7466
Brugia malayi flavodoxin family protein 0.0048 0.0123 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0019 0.0019
Echinococcus multilocularis Tubulin beta 2C chain 0.2156 1 1
Echinococcus granulosus chromobox protein 1 0.0156 0.0631 0.0631
Brugia malayi PHD-finger family protein 0.0024 0.001 0.001
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0961 0.4403 0.4403
Echinococcus granulosus chromobox protein 1 0.0156 0.0631 0.0631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0075 0.0075
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0133 0.052 0.0502
Toxoplasma gondii tubulin, putative 0.011 0.0413 0.0413
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0048 0.0123 0.0123
Loa Loa (eye worm) tubulin alpha 2 0.0407 0.1808 0.1808
Echinococcus granulosus tubulin subunit TubB 0.1616 0.747 0.747
Brugia malayi Valyl-tRNA synthetase 0.0026 0.0019 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0075 0.0075
Loa Loa (eye worm) beta-tubulin 0.2156 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0083 0.0286 0.0286
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0067 0.0211 0.0211
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0019 0.0019
Brugia malayi Sodium:solute symporter family protein 0.004 0.0087 0.0087
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0198 0.0198
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0305 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0123 0.0123
Echinococcus granulosus tubulin alpha chain 0.1616 0.747 0.747
Leishmania major alpha tubulin 0.1616 0.747 0.747
Schistosoma mansoni inositol transporter 0.004 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0114 0.0434 0.0434
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0088 0.0309 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0309 0.0291
Leishmania major p450 reductase, putative 0.0048 0.0123 0.0123
Trichomonas vaginalis chromobox protein, putative 0.0094 0.0341 0.0322
Schistosoma mansoni diflavin oxidoreductase 0.0024 0.001 0.001
Mycobacterium leprae cell division protein FtsZ 0.0554 0.2494 0.5
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0019 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0067 0.0211 0.0211
Trichomonas vaginalis tubulin, putative 0.2156 1 1
Loa Loa (eye worm) hypothetical protein 0.0363 0.1602 0.1602
Loa Loa (eye worm) alpha-tubulin 0.1616 0.747 0.747
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0388 0.0388
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0087 0.0087
Echinococcus multilocularis Tubulin alpha 1 chain 0.1616 0.747 0.747
Entamoeba histolytica tubulin family protein 0.2156 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.1616 0.747 0.747
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0094 0.0341 0.1091
Schistosoma mansoni zinc finger protein 0.0027 0.0024 0.0024
Brugia malayi jmjC domain containing protein 0.0218 0.0922 0.0922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.012 0.012
Onchocerca volvulus 0.0069 0.0221 0.0685
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0019 0.0019
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0048 0.0123 0.0123
Echinococcus granulosus transcription factor Dp 1 0.0077 0.0259 0.0259
Brugia malayi Tubulin alpha chain 0.1616 0.747 0.747
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0124 0.0124
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0554 0.2494 0.5
Brugia malayi FAD binding domain containing protein 0.0029 0.0037 0.0037
Echinococcus granulosus alpha tubulin 0.1616 0.747 0.747
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0388 0.037
Toxoplasma gondii flavodoxin domain-containing protein 0.0024 0.001 0.001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0072 0.0072
Brugia malayi chromobox protein homolog 3 0.0088 0.0309 0.0309
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.0019 0.0019
Brugia malayi Cytochrome P450 family protein 0.0064 0.0198 0.0198
Echinococcus multilocularis Tubulin beta 2C chain 0.2156 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.001
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0075 0.0189
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0554 0.2494 0.248
Echinococcus multilocularis tubulin, beta 4A class IVa 0.2156 1 1
Brugia malayi jmjC domain containing protein 0.0083 0.0286 0.0286
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0035 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0006 0.0006
Echinococcus granulosus Tubulin beta 2C chain 0.2156 1 1
Loa Loa (eye worm) hypothetical protein 0.0323 0.1413 0.1413
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0028 0.0028
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0048 0.0123 0.0197
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0214 0.0214
Onchocerca volvulus 0.0048 0.0124 0.0357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0075 0.0075
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0075 0.0075
Leishmania major beta tubulin 0.2156 1 1
Trypanosoma brucei protein kinase, putative 0.0104 0.0388 0.0388
Schistosoma mansoni hypothetical protein 0.0177 0.0729 0.0729
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.0019 0.0019
Echinococcus multilocularis Chromo domain 0.0026 0.0019 0.0019
Leishmania major cytochrome p450-like protein 0.0037 0.0075 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0075 0.0075
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0124 0.0124
Echinococcus granulosus jumonji domain containing protein 0.0093 0.0334 0.0334
Echinococcus multilocularis muscleblind protein 0.0323 0.1413 0.1413
Echinococcus granulosus histone acetyltransferase KAT2B 0.0279 0.1205 0.1205
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0388 0.0388
Brugia malayi Protein cec-1. 0.0026 0.0019 0.0019
Echinococcus multilocularis tubulin delta chain 0.0554 0.2494 0.2494
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0087 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0075 0.0075
Leishmania major beta tubulin 0.2156 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0554 0.2494 0.5
Echinococcus multilocularis beta tubulin 0.2156 1 1
Brugia malayi AF-10 protein 0.0022 0.0001 0.0001
Trichomonas vaginalis tubulin alpha chain, putative 0.0655 0.2967 0.2953
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0087 0.0087
Schistosoma mansoni cytochrome P450 reductase 0.0048 0.0123 0.0123
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0048 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0071 0.0233 0.0233
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0075 0.0075
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.0019 0.0019
Brugia malayi FAD binding domain containing protein 0.0048 0.0123 0.0123
Schistosoma mansoni NADPH flavin oxidoreductase 0.0024 0.0012 0.0012
Brugia malayi Cytochrome P450 family protein 0.0037 0.0075 0.0075
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1062 0.4875 0.4875
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0019 0.0019
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Echinococcus multilocularis geminin 0.0177 0.0729 0.0729
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0388 0.0388
Leishmania major beta tubulin 0.2156 1 1
Trypanosoma brucei alpha tubulin 0.1616 0.747 0.747
Brugia malayi ecdysteroid receptor 0.0037 0.0075 0.0075
Brugia malayi Tubulin alpha-2 chain 0.1616 0.747 0.747
Brugia malayi Tubulin alpha-2 chain 0.1616 0.747 0.747
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0218 0.0922 0.0922
Schistosoma mansoni jumonji domain containing protein 0.0173 0.0711 0.0711
Leishmania major alpha tubulin 0.1616 0.747 0.747
Echinococcus multilocularis tubulin alpha chain 0.1616 0.747 0.747
Trypanosoma cruzi tubulin delta chain 0.1241 0.5716 0.5716
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0028 0.0028
Trypanosoma cruzi tubulin gamma chain 0.132 0.6083 0.6083
Leishmania major alpha tubulin 0.1616 0.747 0.747
Giardia lamblia Alpha-tubulin 0.1616 0.747 0.7446
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0075 0.0075
Trypanosoma brucei alpha tubulin 0.1616 0.747 0.747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0123 0.0123
Loa Loa (eye worm) tubulin beta-1 chain 0.2156 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.1616 0.747 0.747
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0075 0.0075
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0155 0.0155
Trichomonas vaginalis tubulin alpha chain, putative 0.2156 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0075 0.0075
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0664 0.3008 0.3008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.004 0.004
Echinococcus granulosus Tubulin beta 2C chain 0.2156 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0075 0.0075
Trichomonas vaginalis tubulin gamma chain, putative 0.0554 0.2494 0.248
Toxoplasma gondii alpha tubulin TUBA1 0.1616 0.747 0.747
Echinococcus multilocularis chromobox protein 1 0.0156 0.0631 0.0631
Echinococcus multilocularis tubulin alpha 0.1208 0.5562 0.5562
Trichomonas vaginalis tubulin epsilon chain, putative 0.2156 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0388 0.0294
Trypanosoma cruzi epsilon tubulin, putative 0.1318 0.6076 0.6076
Toxoplasma gondii alpha-tubulin I, putative 0.1616 0.747 0.747
Trichomonas vaginalis chromobox protein, putative 0.0094 0.0341 0.0322
Echinococcus multilocularis tubulin epsilon chain 0.1318 0.6076 0.6076
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.1062 0.4875 0.4875
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0124 0.0124
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0026 0.0019 0.0019
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.021 0.021
Brugia malayi nuclear receptor NHR-88 0.0037 0.0075 0.0075
Onchocerca volvulus 0.0037 0.0075 0.0189
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0048 0.0123 0.0123
Echinococcus multilocularis high affinity choline transporter 1 0.0363 0.1602 0.1602
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0133 0.052 0.052
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1208 0.5562 0.5562
Trypanosoma cruzi epsilon tubulin, putative 0.1318 0.6076 0.6076
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0022 0.0001 0.0001
Trypanosoma brucei zeta tubulin, putative 0.1703 0.788 0.788
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0075 0.0075
Trypanosoma brucei beta tubulin 0.1208 0.5562 0.5562
Chlamydia trachomatis sulfite reductase 0.0029 0.0037 0.5
Brugia malayi tubulin alpha-2 chain 0.1616 0.747 0.747
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0124 0.0124
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1616 0.747 0.7466
Schistosoma mansoni tubulin subunit epsilon 0.1318 0.6076 0.6076
Trichomonas vaginalis sulfite reductase, putative 0.0048 0.0123 0.0104
Trichomonas vaginalis tubulin epsilon chain, putative 0.2156 1 1
Echinococcus granulosus peregrin 0.0076 0.0255 0.0255
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0006 0.0006
Plasmodium vivax heterochromatin protein 1, putative 0.0026 0.0019 0.0019
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0133 0.052 0.052
Brugia malayi RNA binding protein 0.0066 0.021 0.021
Trypanosoma cruzi alpha tubulin, putative 0.1616 0.747 0.747
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0075 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.012 0.012
Entamoeba histolytica tubulin gamma chain 0.132 0.6083 0.6076
Echinococcus multilocularis Tubulin beta 2C chain 0.2156 1 1
Schistosoma mansoni tubulin subunit gamma 0.132 0.6083 0.6083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.012 0.012
Echinococcus granulosus zinc finger protein 0.0027 0.0024 0.0024
Toxoplasma gondii beta-1 tubulin, putative 0.2156 1 1
Echinococcus multilocularis tubulin gamma 1 chain 0.132 0.6083 0.6083
Echinococcus multilocularis methionine synthase reductase 0.0029 0.0037 0.0037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0069 0.0069
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0289 0.1254 0.1254
Trichomonas vaginalis tubulin alpha chain, putative 0.0655 0.2967 0.2953
Brugia malayi nuclear hormone receptor 0.0037 0.0075 0.0075
Giardia lamblia Beta tubulin 0.2156 1 1
Schistosoma mansoni alpha tubulin 0.1616 0.747 0.747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0123 0.0123
Echinococcus granulosus tubulin alpha chain 0.1616 0.747 0.747
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0075 0.0075
Loa Loa (eye worm) heterochromatin protein 1 0.0156 0.0631 0.0631
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.0019 0.0019
Echinococcus multilocularis tubulin subunit beta 0.2156 1 1
Brugia malayi SET domain containing protein 0.0027 0.0024 0.0024
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0048 0.0123 0.0123
Plasmodium falciparum alpha tubulin 1 0.1616 0.747 0.747
Trichomonas vaginalis tubulin alpha chain, putative 0.1208 0.5562 0.5553
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0133 0.052 0.052
Trichomonas vaginalis tubulin gamma chain, putative 0.2156 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0305 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0075 0.0075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0075 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0088 0.0088
Brugia malayi Pre-SET motif family protein 0.003 0.004 0.004
Loa Loa (eye worm) tubulin alpha chain 0.1616 0.747 0.747
Schistosoma mansoni tubulin subunit beta 0.0554 0.2494 0.2494
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0048 0.0123 0.0123
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0289 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Brugia malayi mbt repeat family protein 0.0048 0.0124 0.0124
Schistosoma mansoni tubulin subunit beta 0.2156 1 1
Loa Loa (eye worm) tubulin gamma chain 0.132 0.6083 0.6083
Trichomonas vaginalis tubulin, putative 0.0665 0.3016 0.3003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Plasmodium vivax tubulin alpha chain, putative 0.1616 0.747 0.747
Echinococcus granulosus Tubulin beta 2C chain 0.2156 1 1
Echinococcus granulosus tubulin gamma 1 chain 0.132 0.6083 0.6083
Giardia lamblia Beta tubulin 0.2156 1 1
Leishmania major gamma-tubulin 0.132 0.6083 0.6083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0124 0.0124
Giardia lamblia Delta tubulin 0.0554 0.2494 0.2421
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0124 0.0357
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0075 0.0075
Echinococcus granulosus solute carrier family 5 0.004 0.0087 0.0087
Loa Loa (eye worm) tubulin beta-4 chain 0.2156 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0075 0.0075
Entamoeba histolytica tubulin alpha-1 chain 0.1616 0.747 0.7466
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0075 0.0075
Schistosoma mansoni tubulin subunit beta 0.2156 1 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0001 0.0001
Loa Loa (eye worm) tubulin alpha 2 0.1062 0.4875 0.4875
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0022 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0177 0.0729 0.0729
Trichomonas vaginalis tubulin, putative 0.0655 0.2967 0.2953
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0388 0.0388
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0075 0.0075
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0261 0.0261
Leishmania major cytochrome P450 reductase, putative 0.0042 0.0097 0.0097
Brugia malayi beta-tubulin, identical 0.2156 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0081 0.0277 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0075 0.0075
Leishmania major alpha tubulin 0.1616 0.747 0.747
Plasmodium falciparum heterochromatin protein 1 0.0026 0.0019 0.0019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0786 0.0786
Brugia malayi TAR-binding protein 0.0066 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0123 0.0123
Onchocerca volvulus 0.0238 0.1016 0.3383
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0388 0.037
Schistosoma mansoni chromobox protein 0.0156 0.0631 0.0631
Trichomonas vaginalis tubulin gamma chain, putative 0.132 0.6083 0.6076
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.0259 0.0259
Trypanosoma brucei beta tubulin 0.2156 1 1
Schistosoma mansoni alpha tubulin 0.1616 0.747 0.747
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0881 0.0881
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0075 0.0189
Loa Loa (eye worm) helicase 0.0026 0.0019 0.0019
Leishmania major alpha tubulin 0.1616 0.747 0.747
Leishmania major alpha tubulin 0.1616 0.747 0.747
Trichomonas vaginalis tubulin epsilon chain, putative 0.0554 0.2494 0.248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.0986 0.0986
Trypanosoma cruzi zeta tubulin, putative 0.1703 0.788 0.788
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0075 0.0075
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0155 0.0155
Trypanosoma brucei zeta tubulin 0.1703 0.788 0.788
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0155 0.0155
Leishmania major alpha tubulin 0.1616 0.747 0.747
Schistosoma mansoni hypothetical protein 0.0292 0.1267 0.1267
Brugia malayi tubulin alpha chain - mouse 0.1616 0.747 0.747
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0075 0.0075
Schistosoma mansoni tubulin subunit alpha 0.0554 0.2494 0.2494
Plasmodium falciparum phd finger protein, putative 0.0067 0.0211 0.0211
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0155 0.0155
Loa Loa (eye worm) MBCTL1 0.0055 0.0155 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0388 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0309 0.0291
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0075 0.0075
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0087 0.0087
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0048 0.0123 0.0123
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0075 0.0075
Plasmodium vivax delta tubulin, putative 0.0554 0.2494 0.2494
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0075 0.0075
Echinococcus multilocularis hypothetical protein 0.1616 0.747 0.747
Trichomonas vaginalis tubulin alpha chain, putative 0.0655 0.2967 0.2953
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0048 0.0123 0.0123
Echinococcus multilocularis zinc finger protein 0.0027 0.0024 0.0024
Echinococcus granulosus tubulin beta 1 chain 0.2156 1 1
Echinococcus granulosus geminin 0.0177 0.0729 0.0729
Trichomonas vaginalis tubulin epsilon chain, putative 0.1616 0.747 0.7466
Echinococcus granulosus Tubulin alpha 1 chain 0.1616 0.747 0.747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.1616 0.747 0.747
Toxoplasma gondii PHD-finger domain-containing protein 0.0067 0.0211 0.0211
Plasmodium vivax SET domain protein, putative 0.003 0.004 0.004
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0015 0.0015
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0786 0.0786
Schistosoma mansoni tubulin subunit alpha 0.1616 0.747 0.747
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.016 0.016
Trichomonas vaginalis chromobox protein, putative 0.0156 0.0631 0.0613
Echinococcus granulosus chromobox protein 2 0.0026 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0075 0.0075
Schistosoma mansoni chromobox protein 0.0026 0.0019 0.0019
Brugia malayi Muscleblind-like protein 0.0323 0.1413 0.1413
Leishmania major alpha tubulin 0.1616 0.747 0.747
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0388 0.0388
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0075 0.0075
Trichomonas vaginalis tubulin beta chain, putative 0.2156 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0069 0.0069
Trichomonas vaginalis tubulin beta chain, putative 0.1616 0.747 0.7466
Leishmania major beta tubulin 0.2156 1 1
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1016 0.0999
Schistosoma mansoni tubulin subunit beta 0.2156 1 1
Leishmania major alpha tubulin 0.1616 0.747 0.747
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0048 0.0123 0.0123
Leishmania major alpha tubulin 0.1616 0.747 0.747
Echinococcus multilocularis PHD finger protein rhinoceros 0.0067 0.0211 0.0211
Treponema pallidum cell division protein FtsZ 0.0554 0.2494 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.1616 0.747 0.7466
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0388 0.0388
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0305 0.0305
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0075 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0075 0.0075
Echinococcus granulosus muscleblind protein 0.0323 0.1413 0.1413
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0006 0.0006
Echinococcus granulosus PHD finger protein rhinoceros 0.0067 0.0211 0.0211
Brugia malayi Heterochromatin protein 1 0.0156 0.0631 0.0631
Echinococcus granulosus tubulin subunit beta 0.2156 1 1
Plasmodium falciparum nitric oxide synthase, putative 0.0048 0.0123 0.0123
Entamoeba histolytica tubulin family protein 0.2156 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0022 0.0001 0.0001
Schistosoma mansoni chromobox protein 0.0026 0.0019 0.0019
Giardia lamblia Alpha-tubulin 0.1616 0.747 0.7446
Schistosoma mansoni coup transcription factor 0.0037 0.0075 0.0075
Brugia malayi steroid hormone receptor 0.0037 0.0075 0.0075
Echinococcus granulosus Tubulin alpha 1 chain 0.1616 0.747 0.747
Echinococcus multilocularis Tubulin beta 2C chain 0.2156 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.1616 0.747 0.747
Brugia malayi Cytochrome P450 family protein 0.0037 0.0075 0.0075
Brugia malayi follicle stimulating hormone receptor 0.0232 0.0986 0.0986
Leishmania major beta tubulin 0.2156 1 1
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0124 0.0124
Echinococcus granulosus Chromo domain 0.0026 0.0019 0.0019
Brugia malayi Tubulin beta chain 0.0655 0.2967 0.2967
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0087 0.0087
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0388 0.0388
Trypanosoma brucei beta tubulin 0.2156 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0286 0.0286
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0028 0.0028
Echinococcus granulosus tubulin alpha chain 0.1616 0.747 0.747
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0075 0.0075
Toxoplasma gondii beta-tubulin, putative 0.2156 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0138 0.0544 0.0544
Onchocerca volvulus 0.0026 0.0019 0.000000020004
Loa Loa (eye worm) BEN-1 protein 0.2156 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.1616 0.747 0.7466
Leishmania major delta tubulin, putative 0.1241 0.5716 0.5716
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0009 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0061 0.0042
Brugia malayi CHD4 protein 0.0027 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0388 0.0388
Brugia malayi PHD-finger family protein 0.0067 0.0211 0.0211
Brugia malayi PHD-finger family protein 0.0032 0.005 0.005
Toxoplasma gondii beta tubulin 0.2156 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0075 0.0075
Echinococcus multilocularis peregrin 0.0076 0.0255 0.0255
Schistosoma mansoni tubulin subunit delta 0.0554 0.2494 0.2494
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0075 0.0075
Plasmodium vivax tubulin alpha chain, putative 0.1616 0.747 0.747
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0554 0.2494 0.248
Trypanosoma brucei tubulin gamma chain 0.132 0.6083 0.6083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0124 0.0124
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.0019 0.0019
Echinococcus multilocularis tar DNA binding protein 0.0066 0.021 0.021
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0022 0.0001 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0015 0.0015
Schistosoma mansoni tubulin subunit beta 0.2156 1 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0048 0.0123 0.0123
Loa Loa (eye worm) FAD binding domain-containing protein 0.0048 0.0123 0.0123
Echinococcus granulosus beta tubulin 0.2156 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0075 0.0075
Echinococcus multilocularis Tubulin alpha 1 chain 0.1616 0.747 0.747
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.019 0.0171
Leishmania major beta tubulin 0.2156 1 1
Trypanosoma brucei epsilon tubulin 0.1208 0.5562 0.5562
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.0087
Echinococcus granulosus tubulin alpha chain 0.1616 0.747 0.747
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0218 0.0922 0.0922
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0133 0.052 0.052
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0087 0.0087
Echinococcus granulosus tubulin delta chain 0.0554 0.2494 0.2494
Loa Loa (eye worm) TAR-binding protein 0.0066 0.021 0.021
Plasmodium falciparum tubulin beta chain 0.2156 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0655 0.2967 0.2953
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0001 0.0001
Plasmodium falciparum alpha tubulin 2 0.1616 0.747 0.747
Trypanosoma cruzi p450 reductase, putative 0.0048 0.0123 0.0123
Brugia malayi Tubulin alpha chain 0.0554 0.2494 0.2494
Leishmania major beta tubulin 0.2156 1 1
Leishmania major beta tubulin 0.2156 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.2156 1 1
Schistosoma mansoni sodium/solute symporter 0.004 0.0087 0.0087
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.0309 0.0985
Leishmania major beta tubulin 0.2156 1 1
Brugia malayi hypothetical protein 0.0026 0.0019 0.0019
Loa Loa (eye worm) tubulin alpha-3 chain 0.0961 0.4403 0.4403
Echinococcus granulosus tubulin alpha 3 chain 0.1616 0.747 0.747
Loa Loa (eye worm) alpha-tubulin 0.1616 0.747 0.747
Plasmodium vivax tubulin epsilon chain, putative 0.1318 0.6076 0.6076
Echinococcus multilocularis solute carrier family 5 0.004 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0067 0.0211 0.0211
Echinococcus multilocularis muscleblind protein 1 0.0323 0.1413 0.1413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0075 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0075 0.0075
Entamoeba histolytica tubulin alpha chain, putative 0.1616 0.747 0.7466
Giardia lamblia PHD finger protein 15 0.0067 0.0211 0.0115
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0388 0.0388
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1062 0.4875 0.4865
Echinococcus granulosus tubulin beta 4A class IVa 0.2156 1 1
Brugia malayi Pre-SET motif family protein 0.0209 0.0881 0.0881
Brugia malayi Tubulin beta chain 0.0554 0.2494 0.2494
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0554 0.2494 0.248
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0048 0.0123 0.0123
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0009 0.0009
Echinococcus granulosus high affinity choline transporter 1 0.0363 0.1602 0.1602
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0075 0.0189
Trypanosoma brucei epsilon tubulin 0.1318 0.6076 0.6076
Schistosoma mansoni tar DNA-binding protein 0.0066 0.021 0.021
Onchocerca volvulus 0.0655 0.2967 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0019 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.012 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.008
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0133 0.052 0.052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0123 0.0123
Schistosoma mansoni alpha tubulin 0.1616 0.747 0.747
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.021 0.021

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 23 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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