Detailed information for compound 1067288

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.353 | Formula: C20H17NO4
  • H donors: 1 H acceptors: 3 LogP: 3.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)O)C(=O)c1ccc(=O)n(c1)c1ccc(cc1)C
  • InChi: 1S/C20H17NO4/c1-13-3-6-15(7-4-13)21-12-14(5-10-19(21)23)20(24)17-9-8-16(25-2)11-18(17)22/h3-12,22H,1-2H3
  • InChiKey: WLLLVBXXOMZZJC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0095 0.0248
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0768 0.176
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0165 0.133
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0226 0.0226
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.7112
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0361 0.4451 0.4451
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0165 0.0737
Schistosoma mansoni hypothetical protein 0.0067 0.0722 0.0722
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0000068855 0.0000068855
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1095 0.1095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0000068855 0.0000068855
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0057 0.0131
Echinococcus granulosus pyruvate kinase 0.002 0.0125 0.0125
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0071 0.0768 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.1997 0.4576
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0165 0.0534
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0515 0.0515
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0322 0.0322
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0374 0.121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0218 0.0336
Plasmodium falciparum thioredoxin reductase 0.0043 0.041 0.2305
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0057 0.0131
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Brugia malayi nuclear hormone receptor 0.001 0.0000068855 0.0000068855
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.2413 0.2413
Brugia malayi Cytochrome P450 family protein 0.0017 0.0091 0.0091
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0165 0.0737
Loa Loa (eye worm) hypothetical protein 0.0027 0.0216 0.0216
Brugia malayi Bromodomain containing protein 0.008 0.0884 0.0884
Brugia malayi mbt repeat family protein 0.0051 0.0515 0.0515
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0057 0.1371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0473 0.0473
Trichomonas vaginalis esterase, putative 0.004 0.0374 0.0576
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0374 0.0576
Loa Loa (eye worm) hypothetical protein 0.0048 0.0473 0.0473
Echinococcus multilocularis GPCR, family 2 0.0067 0.0722 0.0722
Leishmania major mitochondrial DNA polymerase beta 0.0354 0.4364 1
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.649 1
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.041 0.041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0187 0.2237 0.7242
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0000068855 0.0000068855
Mycobacterium ulcerans aldehyde dehydrogenase 0.0186 0.2235 0.999
Echinococcus granulosus expressed conserved protein 0.0091 0.1021 0.1021
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0000068855 0.0000068855
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0722 0.0722
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.009 0.0217
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0165 0.1506
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0095 0.0095
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0063 0.0674 0.5432
Mycobacterium ulcerans aldehyde dehydrogenase 0.0186 0.2235 0.999
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0722 0.0722
Loa Loa (eye worm) hypothetical protein 0.0212 0.2562 0.2562
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0366 0.0839
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0063 0.0674 0.2181
Onchocerca volvulus 0.0136 0.1589 0.1589
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0095 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0091 0.0091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0186 0.0425
Echinococcus multilocularis inositol monophosphatase 1 0.0071 0.0768 0.0768
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.1103 0.8891
Echinococcus granulosus serotonin transporter 0.0799 1 1
Echinococcus multilocularis pyruvate kinase 0.002 0.0125 0.0125
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0038 0.0353 0.0353
Trypanosoma brucei trypanothione reductase 0.0043 0.041 0.094
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.041 0.1328
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0095 0.0095
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0145 0.171 0.171
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0136 0.1589 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0604 0.0604
Entamoeba histolytica hypothetical protein 0.0035 0.0318 0.29
Trichomonas vaginalis ran, putative 0.0025 0.0186 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Echinococcus granulosus neuropeptide s receptor 0.0419 0.5185 0.5185
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0095 0.0095
Schistosoma mansoni nuclear hormone receptor 0.001 0.0000068855 0.0000068855
Schistosoma mansoni hypothetical protein 0.0067 0.0722 0.0722
Schistosoma mansoni rab6-interacting 0.0018 0.0095 0.0095
Brugia malayi beta-lactamase family protein 0.004 0.0374 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0000068855 0.0000068855
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0071 0.0768 0.3436
Plasmodium vivax importin-beta 2, putative 0.0034 0.0299 0.1578
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0000068855 0.0000068855
Brugia malayi CHE-14 protein 0.0041 0.0396 0.0396
Schistosoma mansoni bromodomain containing protein 0.0068 0.0737 0.0737
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.2562 0.2562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Toxoplasma gondii ABC1 family protein 0.004 0.0374 0.1672
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0000068855 0.0000068855
Mycobacterium leprae conserved hypothetical protein 0.004 0.0374 0.3014
Echinococcus granulosus cpg binding protein 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0799 1 1
Leishmania major hypothetical protein, conserved 0.004 0.0374 0.0856
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0057 0.0131
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0374 0.0856
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0374 0.121
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0374 0.0576
Leishmania major pyruvate kinase 0.0039 0.0366 0.0839
Brugia malayi Doublecortin family protein 0.0018 0.0095 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Loa Loa (eye worm) hypothetical protein 0.0051 0.0515 0.0515
Echinococcus granulosus neuropeptide receptor A26 0.0419 0.5185 0.5185
Echinococcus multilocularis RUN 0.0018 0.0095 0.0095
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Leishmania major trypanothione reductase 0.0043 0.041 0.094
Loa Loa (eye worm) hypothetical protein 0.007 0.076 0.076
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1095 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0639 0.0639
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0396 0.0396
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.171 0.171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0000068855 0.0000068855
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0366 0.0839
Schistosoma mansoni sodium-dependent amino acid transporter 0.0136 0.1589 0.1589
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0604 0.0604
Echinococcus granulosus geminin 0.0347 0.4271 0.4271
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0091 0.0209
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0354 0.4364 1
Schistosoma mansoni cpg binding protein 0.0028 0.0226 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.649 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0165 0.0378
Mycobacterium tuberculosis Conserved protein 0.004 0.0374 0.121
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) glutathione reductase 0.0043 0.041 0.041
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.1103 0.357
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0691 0.0691
Schistosoma mansoni hypothetical protein 0.0067 0.0722 0.0722
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.1589
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0366 0.0564
Loa Loa (eye worm) hypothetical protein 0.004 0.0374 0.0374
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0496 0.0765
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0000068855 0.0000068855
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.649 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1095 0.1095
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0502 0.115
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0165 0.0165
Schistosoma mansoni cpg binding protein 0.0032 0.027 0.027
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0057 0.0088
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0366 0.0564
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0496 0.222
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0000068855 0.0000068855
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0136 0.1589 0.1589
Echinococcus multilocularis pyruvate kinase 0.002 0.0125 0.0125
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0366 0.2953
Brugia malayi Inositol-1 0.0071 0.0768 0.0768
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1356 0.1356
Echinococcus multilocularis protein patched 0.0041 0.0396 0.0396
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0417 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.009 0.0217
Entamoeba histolytica Ran family GTPase 0.0025 0.0186 0.1695
Onchocerca volvulus 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) hypothetical protein 0.0799 1 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0000068855 0.0000068855
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0722 0.0722
Trypanosoma brucei ISWI complex protein 0.0015 0.0062 0.0143
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0165 0.133
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0218 0.0499
Brugia malayi Thioredoxin reductase 0.0043 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0091 0.0209
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0078 0.0253
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.064 0.1467
Schistosoma mansoni inositol monophosphatase 0.0071 0.0768 0.0768
Plasmodium vivax glutathione reductase, putative 0.0043 0.041 0.2305
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis pyruvate kinase 0.0031 0.0262 0.0262
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.649 1
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0515 0.0515
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0522 0.649 0.649
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0216 0.1973
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0136 0.1589 0.1589
Echinococcus granulosus sodium and chloride dependent glycine 0.0136 0.1589 0.1589
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0000068855 0.0000068855
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0366 0.0839
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0366 0.0839
Echinococcus multilocularis protein dispatched 1 0.0047 0.047 0.047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0502 0.115
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0165 0.0165
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0095 0.0248
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0366 0.0366
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2535 0.2535
Mycobacterium ulcerans lipase LipD 0.004 0.0374 0.1671
Onchocerca volvulus 0.0051 0.0515 0.0515
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0136 0.1589 0.1589
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1621 0.1621
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0000068855 0.0000068855
Onchocerca volvulus 0.0028 0.0226 0.0226
Schistosoma mansoni polycystin 1-related 0.0018 0.0095 0.0095
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.041 0.094
Mycobacterium tuberculosis Conserved protein 0.004 0.0374 0.121
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4942 0.4942
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0722 0.0722
Onchocerca volvulus 0.0031 0.0259 0.0259
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0299 0.1338
Mycobacterium ulcerans beta-lactamase 0.004 0.0374 0.1671
Trichomonas vaginalis glucosylceramidase, putative 0.0361 0.4447 0.6853
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0374 0.0576
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0366 0.0366
Plasmodium falciparum amino acid transporter, putative 0.0136 0.1589 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1928 0.1928
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0174 0.0174
Schistosoma mansoni lipoxygenase 0.005 0.0501 0.0501
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Echinococcus multilocularis geminin 0.0347 0.4271 0.4271
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2902 0.4471
Onchocerca volvulus 0.004 0.0374 0.0374
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0186 0.0425
Brugia malayi Cytochrome P450 family protein 0.0044 0.0427 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1613 0.1613
Echinococcus granulosus importin subunit beta 1 0.0034 0.0299 0.0299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1613 0.1613
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.004 0.0374 0.0374
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.124 0.4015
Schistosoma mansoni loxhd1 0.0018 0.0095 0.0095
Mycobacterium ulcerans hypothetical protein 0.004 0.0374 0.1671
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0057 0.0088
Brugia malayi Pre-SET motif family protein 0.021 0.2535 0.2535
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0165 0.0165
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis sodium and chloride dependent glycine 0.0136 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Schistosoma mansoni hypothetical protein 0.0015 0.0062 0.0062
Schistosoma mansoni sodium/chloride dependent transporter 0.0136 0.1589 0.1589
Schistosoma mansoni coup transcription factor 0.001 0.0000068855 0.0000068855
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0299 0.0685
Brugia malayi CXXC zinc finger family protein 0.0028 0.0226 0.0226
Echinococcus granulosus arachidonate 5 lipoxygenase 0.005 0.0501 0.0501
Loa Loa (eye worm) PHD-finger family protein 0.002 0.013 0.013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0473 0.0473
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0473 0.0473
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0374 0.121
Onchocerca volvulus 0.0239 0.2902 0.2902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0259 0.0259
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0057 0.0057
Echinococcus granulosus pyruvate kinase 0.002 0.0125 0.0125
Schistosoma mansoni pyruvate kinase 0.002 0.0125 0.0125
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0136 0.1589 0.1589
Echinococcus multilocularis neuropeptide s receptor 0.0419 0.5185 0.5185
Brugia malayi RNA, U transporter 1 0.0096 0.109 0.109
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.1842 0.1842
Onchocerca volvulus Glucosylceramidase homolog 0.0342 0.4213 0.4213
Loa Loa (eye worm) hypothetical protein 0.004 0.0374 0.0374
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0186 0.0186
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0085 0.0085
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0374 0.121
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0396 0.061
Toxoplasma gondii thioredoxin reductase 0.0043 0.041 0.1836
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0000068855 0.0000068855
Brugia malayi beta-lactamase 0.004 0.0374 0.0374
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0057 0.0256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0374 0.0374
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0057 0.0255
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0496 0.2866
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0000068855 0.0000068855
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0186 0.2235 0.5121
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Brugia malayi steroid hormone receptor 0.001 0.0000068855 0.0000068855
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0502 0.115
Mycobacterium tuberculosis Conserved protein 0.004 0.0374 0.121
Loa Loa (eye worm) hypothetical protein 0.0023 0.0165 0.0165
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0057 0.0255
Brugia malayi MH2 domain containing protein 0.0117 0.1356 0.1356
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0057 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.649 1
Echinococcus granulosus GPCR family 2 0.0067 0.0722 0.0722
Schistosoma mansoni hypothetical protein 0.04 0.4942 0.4942
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0000068855 0.0000068855
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0496 0.222
Mycobacterium tuberculosis Probable reductase 0.0097 0.1103 0.357
Plasmodium vivax hypothetical protein, conserved 0.0136 0.1589 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0000068855 0.0000068855
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0057 0.0057
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0366 0.2017
Echinococcus multilocularis neuropeptide receptor A26 0.0419 0.5185 0.5185
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis pyruvate kinase 0.0039 0.0366 0.0366
Schistosoma mansoni patched 1 0.0041 0.0396 0.0396
Brugia malayi nuclear receptor NHR-88 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1356 0.1356
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0000068855 0.0000068855
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0057 0.0057
Brugia malayi Importin beta-1 subunit 0.0034 0.0299 0.0299
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0165 0.1506
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.1103 0.357
Schistosoma mansoni hypothetical protein 0.004 0.0377 0.0377
Echinococcus multilocularis snurportin 1 0.0361 0.4451 0.4451
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0085 0.0085
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0007 0.0007
Brugia malayi PHD-finger family protein 0.003 0.0253 0.0253
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.1589
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0374 0.1671
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0095 0.0095
Schistosoma mansoni lipoxygenase 0.0018 0.0095 0.0095
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.2413 0.2413
Treponema pallidum sodium- and chloride- dependent transporter 0.0799 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0000068855 0.0000068855
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0496 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0000068855 0.0000068855
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0085 0.0085
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0165 0.1506
Leishmania major hypothetical protein, conserved 0.0015 0.0062 0.0143
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0186 0.2235 0.2235
Echinococcus multilocularis pyruvate kinase 0.002 0.0125 0.0125
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0186 0.0186
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0318 0.0318
Trypanosoma cruzi ISWI complex protein 0.0015 0.0062 0.0143
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0186 0.0831
Schistosoma mansoni ran 0.0025 0.0186 0.0186
Mycobacterium ulcerans hypothetical protein 0.0187 0.2237 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0473 0.0473
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0165 0.0737
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.2562 0.2562
Loa Loa (eye worm) hypothetical protein 0.0023 0.0165 0.0165
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0071 0.0768 0.1183
Plasmodium falciparum importin beta, putative 0.0034 0.0299 0.1578
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0136 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Toxoplasma gondii hypothetical protein 0.0136 0.1589 0.7112
Schistosoma mansoni zinc finger protein 0.0015 0.0062 0.0062
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.1103 0.357
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.9963 0.9963
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0057 0.0744
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0374 0.121
Toxoplasma gondii hypothetical protein 0.0136 0.1589 0.7112
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0374 0.1671
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0515 0.0515
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.1589
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0722 0.0722
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0366 0.0366
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0396 0.0396
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0604 0.0604
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0374 0.0856
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0057 0.0185
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0374 0.121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1613 0.1613
Echinococcus multilocularis cpg binding protein 0.0032 0.027 0.027
Schistosoma mansoni zinc finger protein 0.0025 0.0186 0.0186
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0000068855 0.0000068855
Schistosoma mansoni hypothetical protein 0.002 0.013 0.013
Leishmania major cytochrome p450-like protein 0.0017 0.0091 0.0209
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0125 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0078 0.0253
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0186 0.0839
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0396 0.0396
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0502 0.115
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0057 0.0131
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0039 0.0366 0.0366
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0165 0.0534
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0071 0.0768 0.1183
Onchocerca volvulus 0.0018 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0000068855 0.0000068855
Onchocerca volvulus 0.0023 0.0165 0.0165
Brugia malayi glutathione reductase 0.0043 0.041 0.041
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0067 0.0722 0.0722
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0174 0.0174
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.0347 0.4271 0.4271
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0041 0.0396 0.0396
Schistosoma mansoni cpg binding protein 0.0032 0.027 0.027
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0136 0.1589 0.1589
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1613 0.1613
Mycobacterium ulcerans aldehyde dehydrogenase 0.0186 0.2235 0.999
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0768 0.176
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0174 0.0174
Loa Loa (eye worm) serotonin transporter b 0.0799 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0377 0.0377
Loa Loa (eye worm) norepinephrine transporter 0.0799 1 1
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0095 0.0095
Leishmania major pyruvate kinase 0.0039 0.0366 0.0839
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0768 0.176
Echinococcus multilocularis zinc finger protein 0.0025 0.0186 0.0186
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0374 0.121
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0309 0.3793 0.3793
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0604 0.0604
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0259 0.1158
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0237 0.0237
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.124 1
Loa Loa (eye worm) hypothetical protein 0.0799 1 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.009 0.0292
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0000068855 0.0000068855
Onchocerca volvulus 0.0799 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1928 0.1928
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0165 0.0378
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0374 0.0856
Plasmodium vivax SET domain protein, putative 0.0031 0.0259 0.1315
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0366 0.0366
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.1103 0.357
Schistosoma mansoni hypothetical protein 0.0035 0.0318 0.0318
Brugia malayi hypothetical protein 0.0035 0.0318 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0361 0.4447 0.6853
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0218 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0000068855 0.0000068855
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0218 0.0336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0374 0.0374
Brugia malayi hypothetical protein 0.0136 0.1589 0.1589
Schistosoma mansoni sodium/chloride dependent transporter 0.0799 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0354 0.4364 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0000068855 0.0000068855
Loa Loa (eye worm) beta-lactamase 0.004 0.0374 0.0374
Schistosoma mansoni sodium/chloride dependent transporter 0.0136 0.1589 0.1589
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0318 0.0318
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.009 0.0404
Loa Loa (eye worm) MBCTL1 0.0058 0.0604 0.0604
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0396 0.0396
Echinococcus multilocularis serotonin transporter 0.0799 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.1103 0.357
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0427 0.0427
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0057 0.0057
Chlamydia trachomatis pyruvate kinase 0.0039 0.0366 0.2017
Loa Loa (eye worm) inositol-1 0.0071 0.0768 0.0768
Giardia lamblia Pyruvate kinase 0.002 0.0125 0.2991
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0259 0.0259
Schistosoma mansoni thyroid hormone receptor 0.001 0.0000068855 0.0000068855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0374 0.0374
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0186 0.0186
Onchocerca volvulus 0.0018 0.0095 0.0095
Giardia lamblia Pyruvate kinase 0.0039 0.0366 0.8789
Echinococcus granulosus FTZ F1 alpha 0.001 0.0000068855 0.0000068855
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0366 0.0366
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0057 0.0131
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0085 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0000068855 0.0000068855
Onchocerca volvulus 0.004 0.0374 0.0374
Mycobacterium leprae Probable lipase LipE 0.004 0.0374 0.3014
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0000068855 0.0000068855
Brugia malayi hypothetical protein 0.0018 0.0095 0.0095
Brugia malayi Bromodomain containing protein 0.0042 0.0402 0.0402
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0604 0.0604
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0417 0.3805
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0366 0.0366
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0216 0.0216
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.2562 0.2562
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0091 0.0209
Brugia malayi ecdysteroid receptor 0.001 0.0000068855 0.0000068855
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0417 0.2347
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0186 0.2235 0.7234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1613 0.1613
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0000068855 0.0000068855
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0165 0.0378
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0515 0.0515
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0515 0.0515
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0638 0.2855
Loa Loa (eye worm) hypothetical protein 0.0058 0.0604 0.0604
Leishmania major importin beta-1 subunit, putative 0.0027 0.0218 0.0499
Loa Loa (eye worm) hypothetical protein 0.004 0.0374 0.0374
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.009 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0000068855 0.0000068855
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0057 0.0256
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0522 0.649 0.649
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0000068855 0.0000068855
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0186 0.0839
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0366 0.1639
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0374 0.0576
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.0768 0.176
Loa Loa (eye worm) hypothetical protein 0.0051 0.0514 0.0514
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0057 0.0744
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0691 0.0691
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0515 0.0515
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0000068855 0.0000068855
Echinococcus granulosus pyruvate kinase 0.002 0.0125 0.0125
Entamoeba histolytica hypothetical protein 0.0035 0.0318 0.29
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0165 0.0737
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0023 0.0165 0.0165
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0186 0.4455
Loa Loa (eye worm) solute carrier family 6 member 4 0.0799 1 1
Brugia malayi beta-lactamase family protein 0.004 0.0374 0.0374
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0722 0.0722
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0000068855 0.0000068855
Plasmodium falciparum glutathione reductase 0.0043 0.041 0.2305
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0000068855 0.0000068855
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0186 0.0425
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0000068855 0.0000068855
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.1589
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.1997 0.4576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0000068855 0.0000068855
Entamoeba histolytica hypothetical protein 0.0035 0.0318 0.29
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0722 0.0722
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0799 1 1
Plasmodium falciparum pyruvate kinase 0.0039 0.0366 0.2017
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0366 0.1637
Echinococcus granulosus snurportin 1 0.0361 0.4451 0.4451
Schistosoma mansoni pyruvate kinase 0.0039 0.0366 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1613 0.1613
Loa Loa (eye worm) acetyltransferase 0.0162 0.1928 0.1928
Schistosoma mansoni hypothetical protein 0.0361 0.4451 0.4451
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1114 0.1114
Schistosoma mansoni rab6-interacting 0.0018 0.0095 0.0095
Mycobacterium ulcerans hypothetical protein 0.0023 0.0165 0.0737
Schistosoma mansoni hypothetical protein 0.0067 0.0722 0.0722
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0136 0.1589 0.1589
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0136 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.004 0.0374 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0000068855 0.0000068855
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0000068855 0.0000068855
Echinococcus multilocularis sodium and chloride dependent glycine 0.0136 0.1589 0.1589
Brugia malayi hypothetical protein 0.0018 0.0095 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0057 0.0131
Loa Loa (eye worm) hypothetical protein 0.0097 0.1095 0.1095
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.005 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.004 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0347 0.4271 0.4271
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0477
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.3089 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.004 0.0377 0.0377
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0057 0.0131
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0057 0.0131
Echinococcus multilocularis pyruvate kinase 0.0039 0.0366 0.0366
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0136 0.1589 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0000068855 0.0000068855
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.124 0.4015
Toxoplasma gondii aldehyde dehydrogenase 0.0186 0.2235 1
Leishmania major GTP-binding protein, putative 0.0025 0.0186 0.0425
Echinococcus granulosus zinc finger protein 0.0025 0.0186 0.0186
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0374 0.0374
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0165 0.0737
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0078 0.0253
Schistosoma mansoni aldehyde dehydrogenase 0.0186 0.2235 0.2235
Loa Loa (eye worm) hypothetical protein 0.0044 0.0432 0.0432
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0136 0.1589 0.1589
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0057 0.0131
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0168 0.1997 0.4576
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1621 0.1621
Entamoeba histolytica hypothetical protein 0.0027 0.0218 0.1989
Brugia malayi mbt repeat family protein 0.0051 0.0515 0.0515
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1613 0.1613
Schistosoma mansoni pyruvate kinase 0.0039 0.0366 0.0366
Trichomonas vaginalis inositol monophosphatase, putative 0.0071 0.0768 0.1183
Onchocerca volvulus 0.004 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.001 0.0000068855 0.0000068855
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4213 0.6492
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.7112
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0034 0.0299 0.0299
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0259 0.0259
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0366 0.0366
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0299 0.0299
Entamoeba histolytica hypothetical protein 0.0035 0.0318 0.29
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0000068855 0.0000068855
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0000068855 0.0000068855
Brugia malayi Cytochrome P450 family protein 0.0017 0.0091 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0078 0.0253
Schistosoma mansoni inositol monophosphatase 0.0071 0.0768 0.0768
Echinococcus granulosus pyruvate kinase 0.0039 0.0366 0.0366
Schistosoma mansoni hypothetical protein 0.004 0.0377 0.0377
Echinococcus granulosus RUN 0.0018 0.0095 0.0095
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0299 0.0685
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0091 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0374 0.0576
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0125 0.0558
Echinococcus granulosus sodium and chloride dependent glycine 0.0136 0.1589 0.1589
Onchocerca volvulus 0.0136 0.1589 0.1589
Echinococcus granulosus pyruvate kinase 0.0039 0.0366 0.0366
Plasmodium falciparum transporter, putative 0.0136 0.1589 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0000068855 0.0000068855
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0000068855 0.0000068855
Echinococcus granulosus dnaJ subfamily B 0.04 0.4942 0.4942
Toxoplasma gondii hypothetical protein 0.0057 0.0595 0.2661
Echinococcus granulosus inositol monophosphatase 1 0.0071 0.0768 0.0768
Brugia malayi Pre-SET motif family protein 0.0031 0.0259 0.0259
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0496 0.0496
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0095
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0374 0.0374
Schistosoma mansoni aldehyde dehydrogenase 0.0186 0.2235 0.2235
Plasmodium falciparum pyruvate kinase 2 0.002 0.0125 0.0441
Treponema pallidum NADH oxidase 0.0015 0.0057 0.0057
Onchocerca volvulus 0.0136 0.1589 0.1589
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0354 0.4364 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0366 0.1186
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0017 0.0017
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0136 0.1589 0.7112
Echinococcus multilocularis expressed conserved protein 0.0091 0.1021 0.1021
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0057 0.0131
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0322 0.0322
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0165 0.0737
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.649 1
Plasmodium vivax amine transporter, putative 0.0136 0.1589 1
Schistosoma mansoni hypothetical protein 0.0145 0.171 0.171
Schistosoma mansoni importin beta-1 0.0034 0.0299 0.0299
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0165 0.0737
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0071 0.0768 0.7011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0091 0.0408
Plasmodium vivax hypothetical protein, conserved 0.004 0.0374 0.2066
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Schistosoma mansoni ran 0.0025 0.0186 0.0186
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0186 0.2235 0.2235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1613 0.1613
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.124 0.4015
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0071 0.0768 0.3433
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.041 0.2305
Trypanosoma cruzi ISWI complex protein 0.0015 0.0062 0.0143
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.002 0.002
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.041 0.041
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0604 0.0604

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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