Detailed information for compound 1106634

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.306 | Formula: C18H14FNO4
  • H donors: 1 H acceptors: 3 LogP: 3.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cn1cc(C(=O)O)c(=O)c2c1c(F)ccc2
  • InChi: 1S/C18H14FNO4/c1-24-12-7-5-11(6-8-12)9-20-10-14(18(22)23)17(21)13-3-2-4-15(19)16(13)20/h2-8,10H,9H2,1H3,(H,22,23)
  • InChiKey: ZMMVCCBNJDVNAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ets 0.001 0.0045 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0249 0.1917
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0034 0.0347
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0034 0.0153
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.012 0.0123
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0034 0.0026
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0034 0.0272
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0628 0.0621
Schistosoma mansoni ferritin 0.0009 0.0034 0.0033
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0125 0.3605
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0034 0.0272
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0731 0.0724
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0798 0.0829
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0008 0.0005
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0034 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.012 0.0219
Echinococcus multilocularis zinc finger protein 0.0022 0.0184 0.0177
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0045 0.0073
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0034 0.0051
Schistosoma mansoni SET domain protein 0.0007 0.0003 0.0001
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0034 0.0347
Schistosoma mansoni ferritin 0.0009 0.0034 0.0033
Loa Loa (eye worm) Smad1 0.0017 0.012 0.0219
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0039 0.007
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0518
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0034 0.0059
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0045 0.004
Schistosoma mansoni myst-related protein 0.0009 0.003 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0798 0.0834
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0798 0.8168
Loa Loa (eye worm) hypothetical protein 0.0096 0.1023 0.1974
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0192 0.0194
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.3305
Schistosoma mansoni smad 0.0007 0.0014 0.0012
Brugia malayi Muscleblind-like protein 0.0307 0.3438 0.6671
Echinococcus multilocularis muscleblind protein 1 0.0307 0.3438 0.3433
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0051
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0034 0.0026
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0975 0.1887
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0008 0.0005
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0034 0.0272
Onchocerca volvulus 0.001 0.0039 0.007
Loa Loa (eye worm) hypothetical protein 0.0457 0.5152 1
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0034 0.0033
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0552 0.6237 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0628 0.0651
Toxoplasma gondii hypothetical protein 0.001 0.0039 0.0197
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0125 0.0118
Plasmodium falciparum importin beta, putative 0.0031 0.0287 0.6318
Brugia malayi RasGEF domain containing protein 0.0007 0.0008 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.6669
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Onchocerca volvulus 0.0007 0.0008 0.0008
Echinococcus granulosus importin subunit beta 1 0.0031 0.0287 0.0293
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Trichomonas vaginalis DNA helicase recq1, putative 0.0048 0.0473 0.4813
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0552 0.6237 1
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.0978 0.0971
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0051
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0034 0.0153
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0798 0.0829
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0069 0.0712 0.1369
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0125 0.0118
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0298 0.0305
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0798 0.8168
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0117 0.012
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0034 0.0026
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0138 0.0253
Schistosoma mansoni ets-related 0.0213 0.2364 0.2476
Entamoeba histolytica hypothetical protein 0.0009 0.003 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0034 0.0272
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0192 0.1911
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0034 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0213
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0034 0.0272
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0034 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0219 0.2189
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0039 0.007
Brugia malayi hypothetical protein 0.0096 0.1023 0.1981
Schistosoma mansoni tsg101-related 0.0056 0.057 0.0595
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0192 0.6265
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0051
Echinococcus multilocularis geminin 0.0348 0.391 0.3905
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0045 0.0038
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0034 0.0026
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0219 0.2189
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0034 0.0347
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0125 0.0118
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0798 0.8168
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0034 0.0272
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.2734 0.5299
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0798 0.0834
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0034 0.0272
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0192 0.1455
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0014 0.0013
Schistosoma mansoni bromodomain containing protein 0.0008 0.0015 0.0013
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.012 0.0118
Brugia malayi Bromodomain containing protein 0.0037 0.0353 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0034 0.0059
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0192 0.1974
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0447 0.454
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0045 0.0038
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0101
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0125 0.2344
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.0334 0.3378
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Schistosoma mansoni Smad4 0.0007 0.0014 0.0012
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Loa Loa (eye worm) hypothetical protein 0.006 0.0614 0.118
Loa Loa (eye worm) hypothetical protein 0.0067 0.0699 0.1344
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0298 0.6591
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Echinococcus granulosus dnaJ subfamily B 0.0841 0.9538 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0975 0.102
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.6669
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.3305
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0053
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0192 0.0359
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0731 0.1406
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Leishmania major importin beta-1 subunit, putative 0.0025 0.0219 0.197
Schistosoma mansoni apoferritin-2 0.0009 0.0034 0.0033
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0975 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0604 0.1159
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0518
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.0634 0.0968
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0082 0.0767
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0298 0.2322
Loa Loa (eye worm) hypothetical protein 0.0045 0.044 0.084
Brugia malayi Smad1 0.0017 0.012 0.0227
Echinococcus granulosus cpg binding protein 0.0064 0.0663 0.0688
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0014 0.0007
Schistosoma mansoni tsg101-related 0.0046 0.0453 0.0472
Chlamydia trachomatis metal transport ATPase 0.0009 0.0034 0.5
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0034 0.0272
Brugia malayi MH2 domain containing protein 0.0017 0.012 0.0227
Brugia malayi N-terminal motif family protein 0.0007 0.0008 0.0008
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0045 0.0045
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0138 0.013
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0192 0.0185
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0133 0.145 0.2805
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0034 0.0026
Schistosoma mansoni regulator of G protein signaling 0.001 0.0039 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0118 0.0121
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0039 0.007
Echinococcus multilocularis ferritin 0.0009 0.0034 0.0027
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.136 0.1424
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0004 0.0001
Schistosoma mansoni myst-related protein 0.0009 0.003 0.0029
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0287 0.2231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0082 0.0767
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0125 0.0118
Echinococcus multilocularis muscleblind protein 0.0307 0.3438 0.3433
Brugia malayi MH1 domain containing protein 0.0017 0.012 0.0227
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0029 0.0256 0.8773
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0125 0.0129
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0192 0.1911
Onchocerca volvulus 0.0457 0.5152 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0034 0.0033
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0034 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0058 0.0518
Schistosoma mansoni DNA helicase recq1 0.0032 0.0298 0.031
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0034 0.0347
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.0008 0.0008
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0045 0.0038
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0034 0.0033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0118 0.0121
Brugia malayi MH1 domain containing protein 0.0017 0.012 0.0227
Loa Loa (eye worm) RecQ helicase 0.0048 0.0473 0.0905
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0034 0.0028
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0034 0.0026
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0034 0.0272
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0298 0.2808
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0287 0.2944
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0125 0.0228
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0039 0.0032
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0034 0.0272
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0034 0.0272
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0014 0.0021
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.0634 0.0968
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0157 0.0291
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0039 0.0033
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0014 0.0007
Schistosoma mansoni importin beta-1 0.0031 0.0287 0.0298
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.0975 0.0968
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.2171 0.421
Schistosoma mansoni cpg binding protein 0.0064 0.0663 0.0693
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0518
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0518
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0298 0.2322
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0073
Schistosoma mansoni DNA helicase recq5 0.0032 0.0298 0.031
Brugia malayi MH2 domain containing protein 0.0017 0.012 0.0227
Schistosoma mansoni hypothetical protein 0.0035 0.0327 0.0341
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0798 0.0791
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0298 0.0573
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.012 0.0113
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0975 1
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0034 0.0347
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0138 0.0136
Brugia malayi Ets-domain containing protein 0.001 0.0045 0.0081
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0045 0.004
Schistosoma mansoni hypothetical protein 0.0348 0.391 0.4098
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0062
Echinococcus granulosus bloom syndrome protein 0.0048 0.0473 0.0489
Onchocerca volvulus Huntingtin homolog 0.0133 0.145 0.2811
Leishmania major hypothetical protein, conserved 0.0015 0.0098 0.0685
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0034 0.0026
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0034 0.0272
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0034 0.0026
Plasmodium vivax importin-beta 2, putative 0.0031 0.0287 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0518
Brugia malayi Ets-domain containing protein 0.007 0.0731 0.1413
Echinococcus multilocularis Smad4 0.0017 0.012 0.0113
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0125 0.1283
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0592
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0125 0.1215
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0034 0.0033
Schistosoma mansoni smad 0.0017 0.012 0.0123
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.0975 0.0968
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0034 0.0028
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.3305
Echinococcus granulosus protein C ets 2 0.001 0.0045 0.004
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0034 0.0039
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0096 0.0093
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0034 0.5
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0298 0.0565
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0334 0.3193
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0034 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Treponema pallidum ATP-dependent DNA helicase 0.0016 0.0117 1
Brugia malayi hypothetical protein 0.0035 0.0327 0.0629
Echinococcus granulosus microtubule associated protein 2 0.075 0.8499 0.891
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0034 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0045 0.004
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0125 0.0123
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0034 0.0272
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0034 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.0841 0.9538 0.9538
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0156 0.0297
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0437 1
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0045 0.004
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0034 0.0001
Schistosoma mansoni ferritin light chain 0.0009 0.0034 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0014 0.0013
Onchocerca volvulus 0.0009 0.0034 0.0059
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0034 0.0272
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0034 0.0028
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0175 0.1796
Schistosoma mansoni dep domain containing protein 0.001 0.0039 0.0039
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0039 0.0062
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0034 0.0347
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0975 0.188
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0045 0.0081
Brugia malayi MH2 domain containing protein 0.0245 0.2734 0.5303
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0034 0.0026
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0034 0.0001
Echinococcus multilocularis bloom syndrome protein 0.0048 0.0473 0.0466
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0217 0.022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0327 0.0335
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0192 0.0367
Schistosoma mansoni ets-related 0.001 0.0045 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0327 0.032
Brugia malayi MH2 domain containing protein 0.0007 0.0014 0.0021
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0298 0.0291
Schistosoma mansoni eyes absent homolog 0.0096 0.1023 0.1071
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.012 0.0219
Brugia malayi Bromodomain containing protein 0.0076 0.0798 0.1543
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0011 0.0035
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0125 0.1215
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0118 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0298 0.0565
Echinococcus multilocularis microtubule associated protein 2 0.075 0.8499 0.8498
Trypanosoma brucei ISWI complex protein 0.0015 0.0098 0.1008
Schistosoma mansoni kinase 0.0047 0.046 0.048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0132 0.0243
Schistosoma mansoni cpg binding protein 0.0064 0.0663 0.0693
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.0975 0.1015
Brugia malayi CXXC zinc finger family protein 0.0059 0.0604 0.1166
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0014
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0039 0.0033
Trichomonas vaginalis DNA helicase recq, putative 0.0048 0.0473 0.4813
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0327 0.0319
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.012 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Echinococcus multilocularis protein C ets 2 0.001 0.0045 0.0038
Trypanosoma cruzi ISWI complex protein 0.0015 0.0098 0.0938
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0034 0.0028
Schistosoma mansoni apoferritin-2 0.0009 0.0034 0.0033
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0798 0.8117
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0118 0.0116
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0034 0.0272
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0034 0.0059
Echinococcus granulosus muscleblind protein 0.0307 0.3438 0.36
Schistosoma mansoni hypothetical protein 0.0348 0.391 0.4098
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0007 0.0014 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0096 0.0093
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0067 0.0699 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0011 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Trypanosoma brucei beta lactamase 0.0062 0.0634 0.6506
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0034 0.0272
Trichomonas vaginalis hypothetical protein 0.0033 0.0304 0.3064
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0045 0.0073
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0975 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0067 0.0699 0.0725
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0039 0.0039
Schistosoma mansoni dishevelled 0.001 0.0039 0.0039
Echinococcus granulosus ferritin 0.0009 0.0034 0.0028
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0975 1
Schistosoma mansoni tsg101-related 0.0056 0.057 0.0595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0082 0.0767
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0082 0.0767
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0014 0.0007
Schistosoma mansoni smad1 5 8 and 0.0017 0.012 0.0123
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0096 0.1023 0.1974
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0117 0.1132
Echinococcus multilocularis cpg binding protein 0.0064 0.0663 0.0656
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0298 0.0291
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0034 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0447 0.454
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0045 0.004
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0039 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0039 0.0033
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0552 0.6237 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0975 0.0968
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0034 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0096 0.0099
Schistosoma mansoni hypothetical protein 0.0335 0.3752 0.3932
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0045 0.0038
Entamoeba histolytica hypothetical protein 0.0025 0.0219 0.2189
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0798 0.8117
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0039 0.0032
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0039 0.007
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0016 0.011 0.3004
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0034 0.0272
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0082 0.0767
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0125 0.097
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0034 0.0272
Schistosoma mansoni ATPase 0.0009 0.0034 0.0033
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0034 0.0153
Schistosoma mansoni bromodomain containing protein 0.0065 0.0668 0.0698
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0798 0.8168
Brugia malayi hypothetical protein 0.0133 0.145 0.2811
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0798 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Trichomonas vaginalis helicase, putative 0.0013 0.0082 0.0767
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0039 0.0062
Schistosoma mansoni hypothetical protein 0.001 0.0045 0.0045
Onchocerca volvulus 0.0059 0.0604 0.1166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0082 0.0767
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0034 0.0272
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0192 0.3997
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Brugia malayi DIX domain containing protein 0.001 0.0039 0.007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0125 0.0118
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0034 0.0026
Loa Loa (eye worm) fli-1 protein 0.0213 0.2364 0.4579
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0045 0.0038
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0034 0.0153
Schistosoma mansoni dishevelled 0.001 0.0039 0.0039
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0125 0.0902
Schistosoma mansoni Smad4 0.0007 0.0014 0.0012
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0034 0.0153
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0034 0.0272
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0034 0.0026
Schistosoma mansoni gabp alpha 0.007 0.0731 0.0764
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0287 0.028
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0096 0.0089
Loa Loa (eye worm) nuclear factor I 0.0009 0.0035 0.0053
Schistosoma mansoni ferritin 0.0009 0.0034 0.0033
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0219 0.2189
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0045 0.0073
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0192 0.1685
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0117 0.1132
Echinococcus multilocularis snurportin 1 0.0335 0.3752 0.3747
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0034 0.0153
Onchocerca volvulus Huntingtin homolog 0.0133 0.145 0.2811
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.3305
Echinococcus multilocularis expressed protein 0.0009 0.0034 0.0027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0217 0.0225
Trichomonas vaginalis ferritin, putative 0.0009 0.0034 0.0275
Schistosoma mansoni hypothetical protein 0.001 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0354 0.0673
Entamoeba histolytica recQ family helicase, putative 0.0016 0.011 0.1058
Loa Loa (eye worm) hypothetical protein 0.0076 0.0798 0.1536
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0034 0.0051
Schistosoma mansoni hypothetical protein 0.002 0.0157 0.0162
Schistosoma mansoni smad1 5 8 and 0.0017 0.012 0.0123
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0034 0.0059
Schistosoma mansoni hypothetical protein 0.0092 0.0978 0.1023
Schistosoma mansoni microtubule-associated protein tau 0.075 0.8499 0.8911
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0129 0.1398 0.22
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0034 0.0153
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0008 0.0005
Schistosoma mansoni Smad4 0.0017 0.012 0.0123
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0327 0.0335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0132 0.0136
Schistosoma mansoni zinc finger protein 0.0015 0.0098 0.0101
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0034 0.0033
Brugia malayi RasGEF domain containing protein 0.0007 0.0008 0.0008
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0034 0.0272
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.038 0.0724
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0034 0.0272
Brugia malayi N-terminal motif family protein 0.0007 0.0008 0.0008
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0034 0.0272
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.0975 0.1015
Schistosoma mansoni cpg binding protein 0.0059 0.0604 0.063
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0217 0.021
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0034 0.0051
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.0975 0.1015
Brugia malayi RasGEF domain containing protein 0.0007 0.0008 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0287 0.2944
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0125 0.0237
Trypanosoma brucei polo-like protein kinase 0.0092 0.0975 1
Brugia malayi hypothetical protein 0.001 0.0039 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0132 0.0136
Entamoeba histolytica Ran family GTPase 0.0023 0.0192 0.1911
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0798 0.1543
Brugia malayi MH1 domain containing protein 0.0009 0.0035 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0132 0.0125
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0129 0.1398 0.22
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.0634 0.0968
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0082 0.0767
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0334 0.3378
Brugia malayi MH1 domain containing protein 0.0009 0.0035 0.0061
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0034 0.0272
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0034 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0082 0.0767
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0034 0.0028
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0034 0.0028
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0045 0.0038
Trichomonas vaginalis ran, putative 0.0023 0.0192 0.1911
Schistosoma mansoni blooms syndrome DNA helicase 0.0031 0.0285 0.0296
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0798 0.8168
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0045 0.004
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0034 0.0104
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0117 0.0836
Brugia malayi N-terminal motif family protein 0.0196 0.2171 0.421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0082 0.0767
Schistosoma mansoni ATPase 0.0009 0.0034 0.0033
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0034 0.0028
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0034 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0287 0.0543
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0073
Echinococcus multilocularis smad 0.0017 0.012 0.0113
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Schistosoma mansoni ran 0.0023 0.0192 0.0199
Echinococcus granulosus snurportin 1 0.0335 0.3752 0.3929
Brugia malayi Bloom's syndrome protein homolog 0.0048 0.0473 0.0913
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0096 0.0089
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0034 0.0026
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0039 0.0039
Brugia malayi hypothetical protein 0.0067 0.0699 0.1351
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0058 0.0518
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0798 0.0829
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0045 0.0073
Loa Loa (eye worm) calcium ATPase 0.0009 0.0034 0.0051
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0014 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0117 0.1132
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0125 0.1283
Trypanosoma cruzi ISWI complex protein 0.0015 0.0098 0.0938
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0453 0.4602
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0298 0.0305
Schistosoma mansoni smad1 5 8 and 0.0017 0.012 0.0123
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0034 0.0272
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0034 0.0153
Brugia malayi Ets-domain containing protein 0.007 0.0731 0.1413
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0124 0.0227
Schistosoma mansoni zinc finger protein 0.0022 0.0184 0.0191
Leishmania major GTP-binding protein, putative 0.0023 0.0192 0.1685
Schistosoma mansoni elf1 0.001 0.0045 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0026 0.0024
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0975 0.1887
Echinococcus multilocularis ets variant gene 4 0.001 0.0045 0.0038
Brugia malayi RNA, U transporter 1 0.0089 0.0947 0.1833
Schistosoma mansoni ferritin 0.0009 0.0034 0.0033
Echinococcus granulosus expressed protein 0.0009 0.0034 0.0028
Brugia malayi hypothetical protein 0.001 0.0039 0.007
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0034 0.0001
Echinococcus granulosus geminin 0.0348 0.391 0.4094
Giardia lamblia Kinase, PLK 0.0092 0.0975 1
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0034 0.0028
Echinococcus granulosus zinc finger protein 0.0022 0.0184 0.0185
Echinococcus granulosus Smad4 0.0017 0.012 0.0118
Brugia malayi transcription factor E74 isoform 0.001 0.0045 0.0081
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0731 0.0759
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0034 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.2734 0.5299
Loa Loa (eye worm) hypothetical protein 0.0196 0.2171 0.4205
Brugia malayi PHD-finger family protein 0.0028 0.0243 0.0466
Schistosoma mansoni ran 0.0023 0.0192 0.0199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1233 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0125 0.0147
Leishmania major hypothetical protein, conserved 0.0022 0.0175 0.1502
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0034 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0058 0.0518
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0175 0.1733
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0039 0.0032
Schistosoma mansoni ferritin light chain 0.0009 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0142 0.1555 0.3008
Brugia malayi hypothetical protein 0.0009 0.0034 0.0059
Brugia malayi Importin beta-1 subunit 0.0031 0.0287 0.0551
Entamoeba histolytica recQ family helicase, putative 0.0035 0.0334 0.3378
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0034 0.0272
Trichomonas vaginalis hypothetical protein 0.0007 0.0011 0.0035
Brugia malayi isocitrate dehydrogenase 0.0017 0.0125 0.0237
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0125 0.0902
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0034 0.0272
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0133 0.145 0.2805
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0334 0.3429
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0798 0.8168
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0975 0.1015
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0798 0.8182
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.3752 0.7278
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0219 0.2189
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0327 0.0341
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0034 0.0059
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0798 0.0791
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0034 0.0347
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0039 0.0032
Brugia malayi Fli-1 protein 0.0213 0.2364 0.4584
Echinococcus granulosus smad 0.0017 0.012 0.0118
Brugia malayi hypothetical protein 0.0457 0.5152 1
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0034 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0975 1
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0034 0.0153
Schistosoma mansoni hypothetical protein 0.0841 0.9538 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0518
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0298 0.0573
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0062
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0008 0.0005

Activities

Activity type Activity value Assay description Source Reference
IP (functional) = 1100 nM Allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced calcium mobilization by FLIPR assay ChEMBL. 20004574

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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