Detailed information for compound 1132140

Basic information

Technical information
  • TDR Targets ID: 1132140
  • Name: 2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3, 4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-6-m ethoxycyclohexa-2,5-diene-1,4-dione
  • MW: 342.472 | Formula: C22H30O3
  • H donors: 0 H acceptors: 2 LogP: 4.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)C=C(C1=O)C[C@]1(C)[C@@H](C)CC[C@]2([C@H]1CCC=C2C)C
  • InChi: 1S/C22H30O3/c1-14-7-6-8-19-21(14,3)10-9-15(2)22(19,4)13-16-11-17(23)12-18(25-5)20(16)24/h7,11-12,15,19H,6,8-10,13H2,1-5H3/t15-,19+,21+,22+/m0/s1
  • InChiKey: DVKAFVFWYAIMKZ-SFPRVHAESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-6-methoxy-1,4-benzoquinone
  • 2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-6-methoxy-p-benzoquinone
  • 2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-6-methoxy-cyclohexa-2,5-diene-1,4-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0012 0.0101
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0027 0.1066
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0009 0.0074
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.012 0.0116
Schistosoma mansoni nuclear receptor nhr-48 0.0059 0.003 0.0369
Mycobacterium ulcerans hypothetical protein 0.0048 0.0018 0.0014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0053 0.0023 0.0125
Brugia malayi nuclear receptor NHR-88 0.0126 0.01 0.0832
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0066 0.0037 0.0461
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0015 0.2073
Leishmania major hypothetical protein, conserved 0.0145 0.012 0.4175
Brugia malayi Cathepsin L-like precursor 0.0056 0.0027 0.0224
Loa Loa (eye worm) hypothetical protein 0.0038 0.0007 0.006
Schistosoma mansoni hypothetical protein 0.08 0.0808 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0126 0.01 0.0832
Brugia malayi Augmenter of liver regeneration 0.0037 0.0007 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0029 0.1986
Brugia malayi hypothetical protein 0.0066 0.0037 0.0311
Brugia malayi tailless protein 0.0059 0.003 0.0249
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0007 0.0284
Brugia malayi Latrophilin receptor protein 2 0.037 0.0356 0.2979
Schistosoma mansoni nuclear receptor 0.0059 0.003 0.0369
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1171 0.1197 1
Brugia malayi ecdysone receptor 0.0059 0.003 0.0249
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.1002
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0065 0.5019
Trichomonas vaginalis glucosylceramidase, putative 0.0277 0.0258 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0126 0.01 0.0832
Brugia malayi Pre-SET motif family protein 0.0034 0.0003 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0005 0.0194
Brugia malayi MH1 domain containing protein 0.0069 0.004 0.0336
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0385 0.0372 0.0367
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.012 0.4539
Brugia malayi photoreceptor-specific nuclear receptor 0.0126 0.01 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0126 0.01 0.0832
Trypanosoma cruzi cysteine peptidase, putative 0.0215 0.0193 0.6833
Leishmania major cathepsin L-like protease 0.0215 0.0193 0.6833
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0059 0.003 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.0111 0.0084 0.0699
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0007 0.0284
Brugia malayi MH2 domain containing protein 0.0069 0.004 0.0336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0005 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0009 0.0159
Loa Loa (eye worm) MH1 domain-containing protein 0.0069 0.004 0.0336
Trypanosoma cruzi cruzipain precursor, putative 0.0215 0.0193 0.6833
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0064
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0048 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.1002
Brugia malayi nuclear receptor NHR-67 0.0059 0.003 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0126 0.01 0.0545
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0126 0.01 0.0545
Onchocerca volvulus 0.0056 0.0027 0.1066
Echinococcus granulosus mothers against decapentaplegic 5 0.0069 0.004 0.022
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.012 0.4539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0126 0.01 0.0832
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0027 0.0224
Echinococcus multilocularis polycomb protein SCMH1 0.0097 0.0069 0.0381
Entamoeba histolytica hypothetical protein 0.0262 0.0243 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0007 0.0091
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0007 0.007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0385 0.0372 0.0368
Echinococcus granulosus thioredoxin glutathione reductase 0.0152 0.0127 0.0696
Entamoeba histolytica hypothetical protein 0.0262 0.0243 1
Toxoplasma gondii ABC1 family protein 0.0145 0.012 0.9425
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.0088 0.006 0.0502
Brugia malayi Cathepsin L-like precursor 0.0056 0.0027 0.0224
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0005 0.0194
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0053 0.0023 0.0651
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0005 0.013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0053 0.0023 0.0125
Mycobacterium tuberculosis Conserved protein 0.0145 0.012 0.0116
Onchocerca volvulus 0.027 0.0251 1
Echinococcus granulosus snurportin 1 0.0653 0.0653 0.3574
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0015 0.0123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0006 0.0047
Brugia malayi hypothetical protein 0.0066 0.0037 0.0311
Loa Loa (eye worm) hypothetical protein 0.0038 0.0007 0.006
Onchocerca volvulus 0.0059 0.003 0.1188
Loa Loa (eye worm) latrophilin receptor protein 2 0.037 0.0356 0.2979
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0029 0.0957
Leishmania major cathepsin L-like protease 0.0056 0.0027 0.0795
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0029 0.0026
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0059 0.003 0.0369
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0152 0.0127 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0027 0.0331
Mycobacterium ulcerans histidinol dehydrogenase 0.9557 1 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0015 0.0081
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0132 0.0129
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0018 0.0154
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0029 0.0243
Trichomonas vaginalis glutathione reductase, putative 0.0053 0.0023 0.0708
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0346 0.0331 0.0328
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.012 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Onchocerca volvulus Bile acid receptor homolog 0.0126 0.01 0.3966
Schistosoma mansoni cellular tumor antigen P53 0.0259 0.024 0.2966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Brugia malayi PHD-finger family protein 0.0057 0.0027 0.0227
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0111 0.0084 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0215 0.0193 0.6833
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0126 0.01 0.1232
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Loa Loa (eye worm) hypothetical protein 0.08 0.0808 0.675
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.002 0.0534
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.012 0.1002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0012 0.0242
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0027 0.1066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0126 0.01 0.0832
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0007 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.012 0.4175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0029 0.0024
Mycobacterium ulcerans bacterioferritin BfrA 0.0044 0.0013 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0126 0.01 0.0832
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0053 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0126 0.01 0.1232
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0005 0.013
Loa Loa (eye worm) nuclear receptor NHR-67 0.0059 0.003 0.0249
Echinococcus granulosus SAM and MBT domain containing protein 0.0097 0.0069 0.0381
Loa Loa (eye worm) hypothetical protein 0.0076 0.0047 0.0396
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0395 0.0382 0.209
Echinococcus granulosus FTZ F1 alpha 0.0126 0.01 0.0545
Toxoplasma gondii NADPH-glutathione reductase 0.0053 0.0023 0.1579
Echinococcus multilocularis ecdysone induced protein 78C 0.0126 0.01 0.0545
Echinococcus granulosus nuclear receptor nhr 48 0.0059 0.003 0.0163
Echinococcus multilocularis cysteine protease 0.0056 0.0027 0.0146
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.1002
Brugia malayi RNA, U transporter 1 0.0174 0.015 0.1254
Loa Loa (eye worm) MH2 domain-containing protein 0.0069 0.004 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0126 0.01 0.0832
Loa Loa (eye worm) beta-lactamase 0.0145 0.012 0.1002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0126 0.01 0.0545
Trypanosoma cruzi cysteine peptidase, putative 0.0215 0.0193 0.6833
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Schistosoma mansoni hypothetical protein 0.0176 0.0152 0.188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0621 0.0619 0.3392
Schistosoma mansoni transcription factor LCR-F1 0.0262 0.0243 0.3003
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0027 0.0831
Echinococcus granulosus smad 0.0069 0.004 0.022
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0259 0.024 0.2002
Loa Loa (eye worm) mbt repeat family protein 0.0097 0.0069 0.0581
Loa Loa (eye worm) hypothetical protein 0.0056 0.0027 0.0224
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0053 0.0023 0.0651
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0059 0.003 0.0163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.012 0.1484
Schistosoma mansoni hypothetical protein 0.0176 0.0152 0.188
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0018 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0346 0.0331 0.0327
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0027 0.0146
Echinococcus granulosus cathepsin l1 0.0056 0.0027 0.0146
Echinococcus multilocularis cysteine protease 0.0056 0.0027 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0027 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0621 0.0619 0.3392
Brugia malayi orphan nuclear receptor NR2E1 0.0059 0.003 0.0249
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0346 0.0331 0.0328
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0032 0.0975
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0111 0.0084 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.012 0.0657
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.012 0.0115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0262 0.0243 0.1329
Schistosoma mansoni apoferritin-2 0.0044 0.0013 0.0167
Trypanosoma brucei trypanothione reductase 0.0152 0.0127 0.4434
Brugia malayi acetyltransferase, GNAT family protein 0.0306 0.0288 0.2409
Echinococcus multilocularis nuclear receptor nhr 48 0.0059 0.003 0.0163
Brugia malayi Pre-SET motif family protein 0.0237 0.0217 0.1809
Schistosoma mansoni ferritin 0.0044 0.0013 0.0167
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0007 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0277 0.0258 1
Onchocerca volvulus 0.0145 0.012 0.4778
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.012 0.0116
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0029 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0097 0.0069 0.0381
Schistosoma mansoni ferritin 0.0044 0.0013 0.0167
Plasmodium falciparum thioredoxin reductase 0.0053 0.0023 0.1469
Plasmodium vivax importin-beta 2, putative 0.0061 0.0032 0.23
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0395 0.0382 0.209
Loa Loa (eye worm) hypothetical protein 0.0038 0.0007 0.006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0126 0.01 0.1232
Brugia malayi Ets-domain containing protein 0.0077 0.0048 0.0401
Schistosoma mansoni apoferritin-2 0.0044 0.0013 0.0167
Brugia malayi Cathepsin L-like precursor 0.0056 0.0027 0.0224
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0029 0.0159
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0018 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0039 0.048
Loa Loa (eye worm) acetyltransferase 0.0306 0.0288 0.2409
Mycobacterium tuberculosis Probable reductase 0.0346 0.0331 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0009 0.0073
Loa Loa (eye worm) fibroinase 0.0056 0.0027 0.0224
Schistosoma mansoni bromodomain containing protein 0.0133 0.0107 0.1324
Echinococcus granulosus ecdysone induced protein 78C 0.0126 0.01 0.0545
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0037 0.0461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Leishmania major trypanothione reductase 0.0152 0.0127 0.4434
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0018 0.0478
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0053 0.0023 0.0651
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.0066 0.0037 0.0311
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0092 0.0064 0.0535
Onchocerca volvulus 0.0038 0.0007 0.0286
Onchocerca volvulus 0.0126 0.01 0.3966
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0015 0.036
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0053 0.0023 0.1469
Trichomonas vaginalis importin beta-1, putative 0.005 0.002 0.0581
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Schistosoma mansoni hypothetical protein 0.0041 0.001 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0027 0.0864
Loa Loa (eye worm) hypothetical protein 0.0066 0.0036 0.0304
Echinococcus multilocularis pyruvate kinase 0.0036 0.0005 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0009 0.0159
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0126 0.01 0.1232
Mycobacterium tuberculosis Conserved protein 0.0145 0.012 0.0116
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0059 0.003 0.0163
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0029 0.0881
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0042 0.0232
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0009 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.012 0.4175
Loa Loa (eye worm) thioredoxin reductase 0.0152 0.0127 0.1061
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0018 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0039 0.048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.002 0.0581
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0059 0.003 0.1188
Schistosoma mansoni ferritin 0.0044 0.0013 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.012 0.4175
Schistosoma mansoni hypothetical protein 0.0261 0.0242 0.2992
Trichomonas vaginalis mercuric reductase, putative 0.0053 0.0023 0.0708
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0262 0.0243 0.1329
Schistosoma mansoni coup transcription factor 0.0126 0.01 0.1232
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0029 0.0881
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0069 0.004 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0621 0.0619 0.7667
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0006 0.0399
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.012 0.0116
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0005 0.0041
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0277 0.0258 0.2158
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Schistosoma mansoni ran 0.0045 0.0015 0.0183
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0018 0.0014
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.012 0.0116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0029 0.209
Onchocerca volvulus 0.0056 0.0027 0.1066
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0056 0.0027 0.1792
Loa Loa (eye worm) hypothetical protein 0.1171 0.1197 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0009 0.0159
Echinococcus granulosus Smad4 0.0069 0.004 0.022
Plasmodium falciparum cysteine proteinase falcipain 3 0.0056 0.0027 0.1792
Schistosoma mansoni nuclear hormone receptor 0.0059 0.003 0.0369
Schistosoma mansoni gabp alpha 0.0077 0.0048 0.0595
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.012 0.1002
Schistosoma mansoni nuclear hormone receptor 0.0059 0.003 0.0369
Brugia malayi Nuclear hormone receptor E75 0.0059 0.003 0.0249
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0009 0.0073
Loa Loa (eye worm) hypothetical protein 0.037 0.0356 0.2979
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0018 0.0493
Echinococcus granulosus cathepsin l cysteine peptidase 0.0056 0.0027 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0041
Plasmodium falciparum importin beta, putative 0.0061 0.0032 0.2199
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0044 0.0013 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0029 0.0881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0003 0.004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0018 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0927 0.0941 0.0938
Loa Loa (eye worm) hypothetical protein 0.0068 0.0039 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0126 0.01 0.0832
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0053 0.0023 0.0651
Trypanosoma cruzi trypanothione reductase, putative 0.0152 0.0127 0.4434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0621 0.0619 0.7667
Mycobacterium tuberculosis Conserved protein 0.0145 0.012 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0053 0.0023 0.0191
Echinococcus granulosus thyroid hormone receptor alpha 0.0059 0.003 0.0163
Schistosoma mansoni hypothetical protein 0.0653 0.0653 0.8079
Brugia malayi Bromodomain containing protein 0.0083 0.0055 0.0459
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0126 0.01 0.0545
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0048 0.0263
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0037 0.0311
Onchocerca volvulus 0.0056 0.0027 0.1066
Schistosoma mansoni ferritin light chain 0.0044 0.0013 0.0167
Loa Loa (eye worm) hypothetical protein 0.0048 0.0018 0.0154
Mycobacterium ulcerans bacterioferritin BfrB 0.0044 0.0013 0.0009
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0006 0.0187
Echinococcus granulosus cathepsin l1 0.0038 0.0007 0.0039
Echinococcus multilocularis geminin 0.0176 0.0152 0.0832
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0037 0.0311
Loa Loa (eye worm) fli-1 protein 0.0233 0.0212 0.1771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.028 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0053 0.0023 0.0019
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0005 0.0194
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0044 0.0013 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0126 0.0099 0.0545
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0007 0.0157
Echinococcus multilocularis smad 0.0069 0.004 0.022
Onchocerca volvulus Cathepsin F homolog 0.0056 0.0027 0.1066
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0027 0.0146
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.1002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.003 0.0163
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Brugia malayi glutathione reductase 0.0152 0.0127 0.1061
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0007 0.0284
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0039 0.0008 0.0068
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.012 0.0116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0126 0.01 0.0545
Onchocerca volvulus 0.0259 0.024 0.9547
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.012 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0116 0.4019
Schistosoma mansoni smad1 5 8 and 0.0069 0.004 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0015 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0277 0.0258 1
Brugia malayi Thioredoxin reductase 0.0152 0.0127 0.1061
Brugia malayi Nuclear hormone receptor-like 1 0.0126 0.01 0.0832
Brugia malayi MH1 domain containing protein 0.0069 0.004 0.0336
Loa Loa (eye worm) Smad1 0.0069 0.004 0.0336
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.037 0.0356 0.1952
Onchocerca volvulus 0.0145 0.012 0.4778
Brugia malayi Cathepsin L-like precursor 0.0056 0.0027 0.0224
Plasmodium falciparum glutathione reductase 0.0152 0.0127 1
Schistosoma mansoni hypothetical protein 0.037 0.0356 0.4413
Loa Loa (eye worm) DR-78 0.0059 0.003 0.0249
Schistosoma mansoni zinc finger protein 0.0046 0.0016 0.0198
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.037 0.0356 0.1952
Schistosoma mansoni ran 0.0045 0.0015 0.0183
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0069 0.004 0.022
Brugia malayi nuclear receptor NHR-88 0.0059 0.003 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0621 0.0619 0.3392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0003 0.0018
Schistosoma mansoni myelin transcription factor 1 myt1 0.0111 0.0084 0.1035
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0053 0.1933
Schistosoma mansoni hypothetical protein 0.037 0.0356 0.4413
Echinococcus multilocularis ferritin 0.0044 0.0013 0.0074
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0009 0.0146
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0056 0.0027 0.1792
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0015 0.0812
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0126 0.01 0.0545
Schistosoma mansoni hypothetical protein 0.0602 0.06 0.7424
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0126 0.01 0.3966
Loa Loa (eye worm) hypothetical protein 0.0097 0.0069 0.0581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Schistosoma mansoni alpha-glucosidase 0.0153 0.0128 0.1584
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0014 0.0079
Leishmania major GTP-binding protein, putative 0.0045 0.0015 0.036
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0005 0.0041
Schistosoma mansoni importin beta-1 0.0061 0.0032 0.0393
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0126 0.01 0.1232
Schistosoma mansoni ap endonuclease 0.0059 0.0029 0.036
Echinococcus granulosus histone acetyltransferase KAT2B 0.0292 0.0275 0.1504
Trichomonas vaginalis esterase, putative 0.0145 0.012 0.4539
Onchocerca volvulus 0.0103 0.0075 0.3001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Schistosoma mansoni ferritin light chain 0.0044 0.0013 0.0167
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0003 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0007 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0621 0.0619 0.5175
Mycobacterium tuberculosis Probable oxidoreductase 0.0385 0.0372 0.0368
Brugia malayi hypothetical protein 0.0059 0.003 0.0249
Entamoeba histolytica Ran family GTPase 0.0045 0.0015 0.0323
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.012 0.1484
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.003 0.0163
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 0.9557 1 1
Schistosoma mansoni zinc finger protein 0.0059 0.003 0.0369
Echinococcus granulosus cathepsin L cysteine proteinase 0.0056 0.0027 0.0146
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.012 0.0115
Schistosoma mansoni Smad4 0.0069 0.004 0.0497
Loa Loa (eye worm) transcription factor SMAD2 0.1015 0.1033 0.8634
Schistosoma mansoni smad1 5 8 and 0.0069 0.004 0.0497
Loa Loa (eye worm) hypothetical protein 0.0036 0.0006 0.0047
Brugia malayi ecdysteroid receptor 0.0126 0.01 0.0832
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0029 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0003 0.004
Onchocerca volvulus 0.0056 0.0027 0.1066
Brugia malayi Smad1 0.0069 0.004 0.0336
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0059 0.003 0.0163
Brugia malayi mbt repeat family protein 0.0097 0.0069 0.0581
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0056 0.0027 0.0224
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0277 0.0258 0.2158
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0007 0.007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0018 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.037 0.0356 0.2979
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0066 0.0037 0.0204
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0059 0.003 0.0163
Schistosoma mansoni pyruvate kinase 0.0036 0.0005 0.006
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0053 0.0023 0.1579
Plasmodium falciparum glutathione reductase 0.0053 0.0023 0.1469
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0126 0.01 0.0545
Echinococcus granulosus GPCR family 2 0.037 0.0356 0.1952
Schistosoma mansoni smad 0.0069 0.004 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Echinococcus granulosus Nuclear hormone receptor HR96 0.0059 0.003 0.0163
Brugia malayi beta-lactamase 0.0145 0.012 0.1002
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.012 0.4539
Brugia malayi MH2 domain containing protein 0.1015 0.1033 0.8634
Leishmania major hypothetical protein, conserved 0.0037 0.0007 0.007
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0196 0.0174 0.6123
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0053 0.0023 0.0651
Brugia malayi Nuclear hormone receptor E75 0.0059 0.003 0.0249
Brugia malayi Cathepsin L-like precursor 0.0038 0.0007 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0621 0.0619 0.3392
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0023 0.0651
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0021 0.0591
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.0217 0.1809
Brugia malayi Cathepsin L-like precursor 0.0056 0.0027 0.0224
Onchocerca volvulus 0.0059 0.003 0.1188
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0018 0.0014
Loa Loa (eye worm) nuclear factor I 0.0038 0.0008 0.0064
Echinococcus multilocularis mothers against decapentaplegic 5 0.0069 0.004 0.022
Leishmania major cathepsin L-like protease 0.0056 0.0027 0.0795
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0042 0.0232
Leishmania major cysteine peptidase A (CPA) 0.0056 0.0027 0.0795
Trichomonas vaginalis ferritin, putative 0.0044 0.0013 0.0341
Brugia malayi beta-lactamase family protein 0.0145 0.012 0.1002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0037 0.0311
Toxoplasma gondii hypothetical protein 0.0048 0.0018 0.1191
Schistosoma mansoni RAR-like nuclear receptor 0.0126 0.01 0.1232
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.001 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0621 0.0619 0.7667
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0007 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0012 0.0242
Leishmania major cathepsin L-like protease 0.0215 0.0193 0.6833
Schistosoma mansoni nuclear receptor 0.0059 0.003 0.0369
Loa Loa (eye worm) nuclear hormone receptor 0.0059 0.003 0.0249
Echinococcus multilocularis histone acetyltransferase MYST2 0.0111 0.0084 0.0458
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Echinococcus granulosus expressed protein 0.0044 0.0013 0.0074
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0014 0.0079
Plasmodium vivax vivapain-2 0.0056 0.0027 0.1898
Loa Loa (eye worm) hypothetical protein 0.0066 0.0037 0.0311
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0116 0.4019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1171 0.1197 1
Schistosoma mansoni ferritin 0.0044 0.0013 0.0167
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0261 0.0242 0.1324
Echinococcus granulosus importin subunit beta 1 0.0061 0.0032 0.0174
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.0069 0.086
Brugia malayi nuclear hormone receptor 0.0126 0.01 0.0832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0126 0.01 0.0832
Onchocerca volvulus 0.0145 0.012 0.4778
Plasmodium vivax thioredoxin reductase, putative 0.0152 0.0127 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0007 0.007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.037 0.0356 0.1952
Loa Loa (eye worm) MBCTL1 0.0111 0.0084 0.0699
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0154 0.0843
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0065 0.5019
Schistosoma mansoni alpha glucosidase 0.0039 0.0009 0.011
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0027 0.0146
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Schistosoma mansoni pyruvate kinase 0.0036 0.0005 0.006
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0126 0.01 0.0832
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.0154 0.0843
Onchocerca volvulus 0.0056 0.0027 0.1066
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0065 0.2387
Mycobacterium ulcerans lipase LipD 0.0145 0.012 0.0115
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.1002
Onchocerca volvulus 0.0034 0.0003 0.013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0006 0.0047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0152 0.0127 0.0696
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0059 0.003 0.0249
Plasmodium vivax glutathione reductase, putative 0.0152 0.0127 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Plasmodium vivax vivapain-2 0.0056 0.0027 0.1898
Echinococcus granulosus geminin 0.0176 0.0152 0.0832
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0053 0.0023 0.0018
Brugia malayi nuclear hormone receptor family member nhr-6 0.0059 0.003 0.0249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Echinococcus multilocularis GPCR, family 2 0.037 0.0356 0.1952
Trichomonas vaginalis ran, putative 0.0045 0.0015 0.0391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0126 0.01 0.0832
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0053 0.0023 0.0018
Brugia malayi conserved hypotetical protein 0.0059 0.003 0.0249
Leishmania major cathepsin L-like protease 0.0056 0.0027 0.0795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.012 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.1002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0006 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0018 0.0014
Leishmania major cathepsin L-like protease 0.0056 0.0027 0.0795
Brugia malayi nuclear receptor RXR 0.0059 0.003 0.0249
Echinococcus granulosus tumor protein p63 0.177 0.1826 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0065 0.0358
Loa Loa (eye worm) glutathione reductase 0.0152 0.0127 0.1061
Onchocerca volvulus Glucosylceramidase homolog 0.0182 0.0158 0.6309
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0066 0.0037 0.0204
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0053 0.0023 0.0651
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.012 0.4539
Onchocerca volvulus 0.0056 0.0027 0.1066
Schistosoma mansoni retinoic acid receptor RXR 0.0126 0.01 0.1232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.002 0.0581
Echinococcus multilocularis thyroid hormone receptor alpha 0.0387 0.0374 0.2047
Onchocerca volvulus Protein ultraspiracle homolog 0.0126 0.01 0.3966
Brugia malayi hypothetical protein 0.0059 0.003 0.0249
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0044 0.0013 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0126 0.01 0.1232
Onchocerca volvulus 0.0048 0.0018 0.0735
Schistosoma mansoni alpha-glucosidase 0.0153 0.0128 0.1584
Trypanosoma brucei glucosidase, putative 0.0039 0.0009 0.0146
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.0154 0.1286
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0027 0.0795
Toxoplasma gondii cathepsin CPL 0.0056 0.0027 0.1898
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0009 0.0455
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0027 0.0331
Brugia malayi Importin beta-1 subunit 0.0061 0.0032 0.0265
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0029 0.5071
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.012 0.4539
Loa Loa (eye worm) hypothetical protein 0.0061 0.0032 0.0265
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0066 0.0037 0.0311
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0027 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0126 0.01 0.0832
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0032 0.0975
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0018 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0009 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0277 0.0258 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0053 0.0023 0.1579
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0126 0.01 0.0545
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0261 0.0242 0.1324
Brugia malayi Fli-1 protein 0.0233 0.0212 0.1771
Schistosoma mansoni smad1 5 8 and 0.0069 0.004 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Brugia malayi beta-lactamase family protein 0.0145 0.012 0.1002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0053 0.0023 0.0651
Trypanosoma cruzi major cysteine proteinase, putative 0.0169 0.0145 0.5081
Mycobacterium tuberculosis Probable dehydrogenase 0.0346 0.0331 0.0328
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0053 0.0023 0.5955
Toxoplasma gondii exonuclease III APE 0.0059 0.0029 0.209
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Echinococcus granulosus histone acetyltransferase MYST2 0.0111 0.0084 0.0458
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0832
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0059 0.003 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0065 0.5019
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0018 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0126 0.01 0.1232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0621 0.0619 0.5175
Schistosoma mansoni thyroid hormone receptor 0.0387 0.0374 0.4626
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0009 0.0159
Loa Loa (eye worm) cysteine protease 0.0056 0.0027 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0018 0.0014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0012 0.0242
Treponema pallidum NADH oxidase 0.0053 0.0023 0.5955
Schistosoma mansoni hypothetical protein 0.037 0.0356 0.4413
Brugia malayi MH1 domain containing protein 0.0038 0.0008 0.0064
Mycobacterium ulcerans hypothetical protein 0.0145 0.012 0.0115
Brugia malayi MH2 domain containing protein 0.0069 0.004 0.0336
Echinococcus multilocularis FTZ F1 alpha 0.0126 0.01 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0126 0.01 0.0832
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0346 0.0331 0.0328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0126 0.01 0.0545
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0053 0.0023 0.0651
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0007 0.0037
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.0069 0.086
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0003 0.0017
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0005 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0145 0.012 0.9425
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0015 0.036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0126 0.01 0.0545
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.028 1
Trichomonas vaginalis set domain proteins, putative 0.027 0.0251 0.9709
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.028 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0126 0.01 0.1232
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0053 0.3917
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0027 0.0831
Loa Loa (eye worm) hypothetical protein 0.0036 0.0006 0.0047
Entamoeba histolytica hypothetical protein 0.0262 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Brugia malayi nuclear hormone receptor family member odr-7 0.0059 0.003 0.0249
Echinococcus multilocularis pyruvate kinase 0.0036 0.0005 0.0027
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0009 0.0159
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0346 0.0331 0.0328
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0097 0.0069 0.086
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0653 0.0653 0.5453
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0032 0.23
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0306 0.0288 0.1579
Schistosoma mansoni hypothetical protein 0.037 0.0356 0.4413
Echinococcus granulosus polycomb protein SCMH1 0.0097 0.0069 0.0381
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0029 0.0243
Onchocerca volvulus 0.0056 0.0027 0.1066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0023 0.0651
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0039 0.0212
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0126 0.01 0.0832
Echinococcus multilocularis expressed protein 0.0044 0.0013 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0169 0.646
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0053 0.0023 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Toxoplasma gondii thioredoxin reductase 0.0152 0.0127 1
Entamoeba histolytica hypothetical protein 0.0262 0.0243 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0154 0.0843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0029 0.0881
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0018 0.0478
Echinococcus multilocularis zinc finger protein 0.0046 0.0016 0.0088
Brugia malayi Serotonin receptor 0.1002 0.1019 0.8516
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0018 0.0493
Echinococcus granulosus Nuclear hormone receptor HR96 0.0059 0.003 0.0163
Loa Loa (eye worm) hypothetical protein 0.0048 0.0018 0.0154
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0005 0.0041
Giardia lamblia NADH oxidase lateral transfer candidate 0.0053 0.0023 0.3751
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.0154 0.1286
Echinococcus granulosus ferritin 0.0044 0.0013 0.0074
Schistosoma mansoni ap endonuclease 0.0059 0.0029 0.036
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0015 0.0123
Schistosoma mansoni thyroid hormone receptor 0.0387 0.0374 0.4626
Brugia malayi Ets-domain containing protein 0.0077 0.0048 0.0401
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0009 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0037 0.0311
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0126 0.0099 0.0545
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0009 0.0146
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Brugia malayi latrophilin 2 splice variant baaae 0.08 0.0808 0.675
Echinococcus multilocularis snurportin 1 0.0653 0.0653 0.3574
Brugia malayi Steroid receptor seven-up type 2 0.0126 0.01 0.0832
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0032 0.0174
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Schistosoma mansoni ets-related 0.0233 0.0212 0.2623
Trichomonas vaginalis glucosylceramidase, putative 0.0277 0.0258 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0007 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0126 0.01 0.0832
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0018 0.0493
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0126 0.01 0.0545
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0007 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.028 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0018 0.0154
Leishmania major cathepsin L-like protease 0.0056 0.0027 0.0795
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0005 0.0041
Brugia malayi nuclear receptor RXR 0.0066 0.0037 0.0311
Brugia malayi Calcitonin receptor-like protein seb-1 0.1171 0.1197 1
Brugia malayi MH1 domain containing protein 0.0038 0.0008 0.0064
Brugia malayi steroid hormone receptor 0.0126 0.01 0.0832
Loa Loa (eye worm) hypothetical protein 0.014 0.0115 0.0958
Onchocerca volvulus 0.0097 0.0069 0.277
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0009 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0003 0.0037
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0053 0.0023 1
Trichomonas vaginalis glucosylceramidase, putative 0.0277 0.0258 1
Brugia malayi nuclear hormone receptor 0.0059 0.003 0.0249
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0249
Brugia malayi Cathepsin L-like precursor 0.0056 0.0027 0.0224
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0006 0.0001
Echinococcus granulosus zinc finger protein 0.0046 0.0016 0.0088
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0009 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Loa Loa (eye worm) hypothetical protein 0.0066 0.0037 0.0311
Mycobacterium ulcerans beta-lactamase 0.0145 0.012 0.0115
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0009 0.0049
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0002 0.0011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0014 0.0179
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0009 0.0049
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0029 0.0932
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0039 0.0212
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0029 0.0159
Leishmania major importin beta-1 subunit, putative 0.005 0.002 0.0534
Mycobacterium leprae Probable lipase LipE 0.0145 0.012 0.0115
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0059 0.003 0.1188
Loa Loa (eye worm) MH2 domain-containing protein 0.1015 0.1033 0.8634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Mycobacterium leprae conserved hypothetical protein 0.0145 0.012 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0018 0.0015
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0111 0.0084 0.0699
Echinococcus granulosus pyruvate kinase 0.0036 0.0005 0.0027
Echinococcus multilocularis tumor protein p63 0.177 0.1826 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.037 0.0356 0.1952
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0048 0.0263
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0065 0.2387
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0027 0.0864
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0126 0.01 0.0545
Loa Loa (eye worm) ctsf protein 0.0056 0.0027 0.0224
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0009 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0215 0.0193 0.6833
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0385 0.0372 0.0368
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0007 0.006
Loa Loa (eye worm) steroid hormone receptor 0.0126 0.01 0.0832
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0015 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0027 0.0864
Entamoeba histolytica cysteine protease, putative 0.0056 0.0027 0.0831
Echinococcus granulosus pyruvate kinase 0.0036 0.0005 0.0027
Brugia malayi Bromodomain containing protein 0.0156 0.0131 0.1097
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0306 0.0288 0.3569
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0126 0.01 0.0832
Leishmania major cathepsin L-like protease 0.0215 0.0193 0.6833
Brugia malayi hypothetical protein 0.0262 0.0243 0.2027
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0006 0.0059
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0053 0.0023 0.5955
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0015 0.0931
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0169 0.646
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0012 0.0242
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0053 0.0023 0.1579
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0158 0.6055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0126 0.01 0.0545
Echinococcus granulosus TGF beta signal transducer SmadC 0.0069 0.004 0.022
Echinococcus multilocularis Smad4 0.0069 0.004 0.022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0039 0.0008 0.0068
Schistosoma mansoni hypothetical protein 0.0262 0.0243 0.3003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0116 0.4019
Entamoeba histolytica hypothetical protein 0.005 0.002 0.0527
Loa Loa (eye worm) hypothetical protein 0.0036 0.0006 0.0047
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0059 0.003 0.0369
Brugia malayi cathepsin L-like precursor 0.0038 0.0007 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0027 0.0864
Plasmodium falciparum thioredoxin reductase 0.0152 0.0127 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0097 0.0069 0.277
Mycobacterium ulcerans hypothetical protein 0.0157 0.0132 0.0128
Brugia malayi mbt repeat family protein 0.0097 0.0069 0.0581
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0015 0.036
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0029 0.0957
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0053 0.0023 0.0282
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0053 0.0023 0.1469

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.1 uM Cytotoxicity against human K562 cells by MTT assay ChEMBL. 19995673
IC50 (ADMET) = 5.5 uM Cytotoxicity against human phytohemagglutininin-stimulated PBMC cells assessed as growth inhibition by MTT assay ChEMBL. 19995673
IC50 (ADMET) = 5.9 uM Cytotoxicity against human PBMC cells by MTT assay ChEMBL. 19995673
IC50 (functional) = 13.3 uM Cytotoxicity against human HeLa cells assessed as decrease in total cellular protein by kenacid blue R binding method ChEMBL. 19995673
MIC (functional) = 50 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 by serial dilution method ChEMBL. 19995673

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19995673

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.