Detailed information for compound 114192

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.53 | Formula: C23H26N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1N(Cc1ccccc1)Cc1ccccc1)C)NS(=O)(=O)C
  • InChi: 1S/C23H26N2O2S/c1-18-14-15-22(24-28(3,26)27)19(2)23(18)25(16-20-10-6-4-7-11-20)17-21-12-8-5-9-13-21/h4-15,24H,16-17H2,1-3H3
  • InChiKey: QKZSCCWAEXBTGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.2225 0.4145 0.4145
Loa Loa (eye worm) hypothetical protein 0.0139 0.0243 0.0243
Brugia malayi Calcitonin receptor-like protein seb-1 0.0126 0.0219 0.0219
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.002 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.4667 0.8715 0.8715
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0635 0.1172 0.1849
Entamoeba histolytica hypothetical protein 0.0148 0.0259 0.0622
Brugia malayi Papain family cysteine protease containing protein 0.128 0.2377 0.2377
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0028 0.0041
Schistosoma mansoni hypothetical protein 0.0086 0.0145 0.0145
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0009 0.0009
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0147 0.0258 0.0623
Brugia malayi cathepsin L-like cysteine proteinase 0.0635 0.1172 0.1172
Echinococcus granulosus alkaline phosphatase 0.0133 0.0231 0.0231
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0133 0.0231 0.0231
Schistosoma mansoni SET domain protein 0.0028 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0012 0.0006 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.002 0.0028
Brugia malayi Phosphoglycerate kinase 0.0139 0.0243 0.0243
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0058 0.0089
Plasmodium vivax vivapain-1 0.128 0.2377 0.5727
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0015 0.0012 0.0016
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0013 0.0008 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0074 0.0083
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0018 0.0026
Plasmodium vivax serine-repeat antigen (SERA) 0.0635 0.1172 0.2813
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0099 0.0167 0.0167
Onchocerca volvulus 0.0013 0.0008 0.0019
Echinococcus multilocularis cysteine protease 0.2225 0.4145 0.4145
Loa Loa (eye worm) hypothetical protein 0.158 0.294 0.294
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0012 0.0012
Brugia malayi cathepsin L precursor 0.0635 0.1172 0.1172
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0017 0.0015 0.0015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0635 0.1172 0.1172
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0092 0.0092
Leishmania major GTP-binding protein, putative 0.0017 0.0015 0.0016
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0047 0.0072
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0002 0.0001
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.001 0.0001 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0644 0.1188 0.1188
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0014 0.0014
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0089 0.0149 0.0147
Mycobacterium ulcerans lipase LipD 0.0056 0.0088 0.272
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0089 0.0149 0.2245
Schistosoma mansoni phosphoglycerate kinase 0.0139 0.0243 0.0243
Loa Loa (eye worm) PHD-finger family protein 0.0047 0.0071 0.0071
Onchocerca volvulus Cathepsin L homolog 0.2225 0.4145 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0012 0.0024
Brugia malayi PHD-finger family protein 0.0017 0.0015 0.0015
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.001 0.0001 0.0001
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0156 0.0276 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Echinococcus granulosus snurportin 1 0.0251 0.0452 0.0452
Brugia malayi Papain family cysteine protease containing protein 0.128 0.2377 0.2377
Brugia malayi Bromodomain containing protein 0.0031 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0635 0.1172 0.1849
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0024 0.0028 0.0041
Brugia malayi 6-phosphofructokinase 0.0089 0.0149 0.0149
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2225 0.4145 0.4145
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0149 0.0233
Loa Loa (eye worm) fibroinase 0.2225 0.4145 0.4145
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0011 0.0015
Trypanosoma brucei phosphoglycerate kinase 0.0139 0.0243 0.0277
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0361 0.0657 1
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0103 0.0103
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0635 0.1172 0.1172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0635 0.1172 0.1849
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0074 0.0083
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0015 0.0012 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.0635 0.1172 0.1172
Trypanosoma cruzi ISWI complex protein 0.0012 0.0006 0.0005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0039 0.0056 0.0134
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0013 0.0008 0.0008
Echinococcus granulosus expressed protein 0.0013 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0056 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0635 0.1172 0.1849
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0011 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.0056 0.0088 0.1326
Giardia lamblia Encystation-specific protease 0.0635 0.1172 0.1849
Entamoeba histolytica Ran family GTPase 0.0017 0.0015 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0088 0.01
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0056 0.0088 0.1326
Echinococcus multilocularis muscleblind protein 1 0.0275 0.0497 0.0497
Loa Loa (eye worm) aldehyde dehydrogenase 0.001 0.0001 0.0001
Leishmania major phosphoglycerate kinase B, cytosolic 0.0139 0.0243 0.0277
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0013 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0056 0.0088 0.1326
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0017 0.0015 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0039 0.0056 0.0056
Schistosoma mansoni phd finger protein 0.001 0.0001 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.0321 0.0321
Echinococcus granulosus cathepsin b 0.5354 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0259 0.0259
Trichomonas vaginalis ran, putative 0.0017 0.0015 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2225 0.4145 0.655
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0133 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0635 0.1172 0.1849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.158 0.294 0.4644
Brugia malayi mbt repeat family protein 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0635 0.1172 0.2813
Schistosoma mansoni flap endonuclease-1 0.0019 0.0019 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0058 0.0058
Brugia malayi Importin beta-1 subunit 0.0023 0.0027 0.0027
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0139 0.0243 0.0381
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0104 0.0118
Brugia malayi jmjC domain containing protein 0.0059 0.0092 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0058 0.0058
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.0321 0.0321
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0139 0.0243 0.0381
Giardia lamblia Hypothetical protein 0.0635 0.1172 0.1849
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0088 0.0087
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0012 0.0012
Giardia lamblia Cathepsin B precursor 0.3391 0.6328 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.0027 0.0029
Entamoeba histolytica cysteine protease, putative 0.2225 0.4145 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0019 0.0018 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0008 0.0007
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0089 0.0149 0.0169
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2225 0.4145 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0039 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0126 0.0219 0.0219
Echinococcus granulosus jumonji domain containing protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0635 0.1172 0.2812
Toxoplasma gondii exonuclease III APE 0.0015 0.0012 0.0016
Onchocerca volvulus 0.2225 0.4145 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0013 0.0008 0.0008
Echinococcus multilocularis bloom syndrome protein 0.002 0.002 0.002
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0008 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.158 0.294 0.294
Trypanosoma cruzi cruzipain precursor, putative 0.4667 0.8715 0.8715
Loa Loa (eye worm) hypothetical protein 0.0635 0.1172 0.1172
Schistosoma mansoni DNA polymerase eta 0.0064 0.0103 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0126 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Giardia lamblia Cathepsin L precursor 0.0635 0.1172 0.1849
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0008 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0039 0.0039
Onchocerca volvulus 0.0013 0.0008 0.0019
Toxoplasma gondii cathepsin B 0.3391 0.6328 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0139 0.0243 0.0381
Trypanosoma brucei ISWI complex protein 0.0012 0.0006 0.0005
Leishmania major hypothetical protein, conserved 0.0015 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.128 0.2377 0.3755
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0011 0.0011
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0013 0.0008 0.0008
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0635 0.1172 0.2813
Brugia malayi Cathepsin L-like precursor 0.158 0.294 0.294
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0012 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0012 0.0154
Echinococcus multilocularis alkaline phosphatase 0.0133 0.0231 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0013 0.0008 0.0008
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0021 0.0023 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0104 0.322
Leishmania major cathepsin L-like protease 0.2225 0.4145 0.4756
Trypanosoma cruzi cysteine peptidase, putative 0.0644 0.1188 0.1187
Echinococcus granulosus geminin 0.0254 0.0458 0.0458
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0011 0.0011
Echinococcus granulosus muscleblind protein 0.0275 0.0497 0.0497
Brugia malayi polk-prov protein 0.0035 0.0049 0.0049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0056 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0086 0.0145 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0012 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0012 0.0009
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0635 0.1172 0.1849
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0013 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.2225 0.4145 0.4145
Echinococcus multilocularis SAM and MBT domain containing protein 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Trypanosoma brucei cysteine peptidase C (CPC) 0.3391 0.6328 0.7261
Brugia malayi PHD-finger family protein 0.0047 0.0071 0.0071
Giardia lamblia Cysteine protease 0.0635 0.1172 0.1849
Echinococcus granulosus dna polymerase eta 0.0064 0.0103 0.0103
Schistosoma mansoni ran 0.0017 0.0015 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0311 0.0565 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.128 0.2377 0.3755
Loa Loa (eye worm) 6-phosphofructokinase 0.0089 0.0149 0.0149
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.128 0.2377 0.2726
Mycobacterium ulcerans beta-lactamase 0.0056 0.0088 0.272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.158 0.294 0.4644
Loa Loa (eye worm) hypothetical protein 0.0635 0.1172 0.1172
Plasmodium vivax JmjC domain containing protein 0.0015 0.0011 0.0009
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.4667 0.8715 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0635 0.1172 0.1172
Brugia malayi Aldehyde dehydrogenase protein 4 0.001 0.0001 0.0001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0012 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0012 0.0016
Plasmodium falciparum importin beta, putative 0.0023 0.0027 0.0045
Echinococcus granulosus flap endonuclease 1 0.0021 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0275 0.0497 0.0497
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0051 0.0078 0.0077
Loa Loa (eye worm) hypothetical protein 0.0044 0.0066 0.0066
Echinococcus multilocularis cathepsin b 0.5354 1 1
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Plasmodium vivax unspecified product 0.0635 0.1172 0.2813
Echinococcus granulosus 6 phosphofructokinase 0.0089 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Brugia malayi Muscleblind-like protein 0.0275 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0635 0.1172 0.1172
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0039 0.0039
Giardia lamblia Cathepsin B precursor 0.3391 0.6328 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Schistosoma mansoni cathepsin s 0.0644 0.1188 0.1188
Mycobacterium ulcerans hypothetical protein 0.0056 0.0088 0.272
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0011 0.0011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0009 0.0009
Plasmodium falciparum cysteine proteinase falcipain 1 0.128 0.2377 0.5726
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0008 0.0007
Entamoeba histolytica G protein alpha subunit, putative 0.0013 0.0008 0.0015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0635 0.1172 0.2813
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0008 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.0015 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0056 0.0088 0.0137
Loa Loa (eye worm) hypothetical protein 0.2225 0.4145 0.4145
Brugia malayi Cathepsin L-like cysteine proteinase 0.158 0.294 0.294
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0139 0.0243 1
Trichomonas vaginalis D-aminoacylase, putative 0.0056 0.0088 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0149 0.0233
Echinococcus granulosus cathepsin b 0.5354 1 1
Onchocerca volvulus 0.0104 0.0178 0.043
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3391 0.6328 0.6328
Plasmodium falciparum serine repeat antigen 3 0.0635 0.1172 0.2812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0635 0.1172 0.1849
Mycobacterium tuberculosis Probable hydrolase 0.0056 0.0088 0.1326
Loa Loa (eye worm) ctsf protein 0.2225 0.4145 0.4145
Onchocerca volvulus 0.2225 0.4145 1
Echinococcus multilocularis 6 phosphofructokinase 0.0089 0.0149 0.0149
Leishmania major cathepsin L-like protease 0.2225 0.4145 0.4756
Plasmodium vivax vivapain-2 0.2225 0.4145 1
Schistosoma mansoni cathepsin B (C01 family) 0.0635 0.1172 0.1172
Entamoeba histolytica cysteine proteinase, putative 0.128 0.2377 0.5733
Brugia malayi Cathepsin L-like precursor 0.2225 0.4145 0.4145
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0012 0.0315
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0056 0.0088 0.0088
Schistosoma mansoni ran 0.0017 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Brugia malayi Papain family cysteine protease containing protein 0.2225 0.4145 0.4145
Plasmodium vivax serine-repeat antigen (SERA) 0.0635 0.1172 0.2813
Toxoplasma gondii cathepsin CPL 0.2225 0.4145 0.655
Trypanosoma cruzi cysteine peptidase, putative 0.4667 0.8715 0.8715
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0054
Plasmodium falciparum serine repeat antigen 9 0.0635 0.1172 0.2812
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.0013
Giardia lamblia Hypothetical protein 0.0635 0.1172 0.1849
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0024 0.0028 0.0041
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0635 0.1172 0.2813
Leishmania major cathepsin L-like protease 0.2225 0.4145 0.4756
Onchocerca volvulus 0.0039 0.0056 0.0134
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0251 0.0452 0.0452
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0017 0.0015 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0058 0.0058
Echinococcus granulosus phd:f box containing protein 0.0015 0.0011 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.2225 0.4145 0.4145
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0024 0.0028 0.1086
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0139 0.0243 0.0381
Plasmodium vivax flap endonuclease 1, putative 0.0021 0.0023 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0104 0.322
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.002 0.0028
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0008 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0056 0.0088 0.0137
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0635 0.1172 0.2813
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.001 0.0001 0.0004
Trichomonas vaginalis DNA helicase recq, putative 0.001 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0149 0.0233
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0635 0.1172 0.1849
Giardia lamblia Cathepsin L precursor 0.0635 0.1172 0.1849
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0018 0.0027
Echinococcus multilocularis cathepsin L 0.128 0.2377 0.2377
Loa Loa (eye worm) hypothetical protein 0.0031 0.0041 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0311 0.0565 0.0565
Brugia malayi PHD-finger family protein 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0049 0.0049
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0051 0.0078 0.0077
Toxoplasma gondii PHD-finger domain-containing protein 0.0047 0.0071 0.011
Entamoeba histolytica cysteine proteinase 1, putative 0.128 0.2377 0.5733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0011 0.0009
Echinococcus granulosus cathepsin L cysteine proteinase 0.2225 0.4145 0.4145
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0635 0.1172 0.1172
Plasmodium falciparum phd finger protein, putative 0.0047 0.0071 0.0152
Loa Loa (eye worm) MBCTL1 0.0044 0.0066 0.0066
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0321 0.0321
Brugia malayi aldehyde dehydrogenase 0.001 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Brugia malayi Pre-SET motif family protein 0.003 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0013 0.0008 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0104 0.0118
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Onchocerca volvulus 0.2225 0.4145 1
Schistosoma mansoni hypothetical protein 0.0251 0.0452 0.0452
Schistosoma mansoni myelin transcription factor 1 myt1 0.0044 0.0066 0.0066
Brugia malayi Latrophilin receptor protein 2 0.004 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0635 0.1172 0.2824
Leishmania major cathepsin L-like protease 0.4667 0.8715 1
Onchocerca volvulus 0.0056 0.0088 0.0213
Entamoeba histolytica cysteine protease, putative 0.0635 0.1172 0.2824
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0018 0.0017 0.0017
Brugia malayi Cathepsin L-like precursor 0.0644 0.1188 0.1188
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0019 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0058
Echinococcus multilocularis zinc finger protein 0.0016 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.2225 0.4145 0.4756
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.0001 0.0001
Echinococcus granulosus cathepsin L cysteine protease 0.128 0.2377 0.2377
Plasmodium falciparum serine repeat antigen 7 0.0635 0.1172 0.2812
Leishmania major DNA damage repair protein, putative 0.0013 0.0008 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0311 0.0565 0.0565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0088 0.0087
Echinococcus multilocularis cathepsin b 0.5354 1 1
Brugia malayi Phosphoglycerate kinase 0.0051 0.0078 0.0078
Entamoeba histolytica cysteine protease, putative 0.0635 0.1172 0.2824
Echinococcus granulosus phosphoglycerate kinase 1 0.0139 0.0243 0.0243
Mycobacterium tuberculosis Conserved protein 0.0056 0.0088 0.1326
Echinococcus granulosus PHD finger protein rhinoceros 0.0047 0.0071 0.0071
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0008 0.0008
Onchocerca volvulus 0.0013 0.0008 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.2225 0.4145 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0104 0.0103
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0058 0.0089
Mycobacterium tuberculosis Conserved protein 0.0056 0.0088 0.1326
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0321 0.0321
Echinococcus multilocularis flap endonuclease 1 0.0021 0.0023 0.0023
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.001 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.128 0.2377 0.2726
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.001 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0011 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0259 0.0259
Leishmania major cathepsin L-like protease 0.2225 0.4145 0.4756
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0104 0.0103
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0008 0.0008
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0044 0.0066 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.2225 0.4145 0.4145
Schistosoma mansoni importin beta-1 0.0023 0.0027 0.0027
Trichomonas vaginalis esterase, putative 0.0056 0.0088 0.0137
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.001 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0015
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0008 0.0008
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0013 0.0008 0.0008
Toxoplasma gondii ABC1 family protein 0.0056 0.0088 0.0137
Plasmodium vivax unspecified product 0.0644 0.1188 0.2854
Brugia malayi fibroinase precursor 0.0635 0.1172 0.1172
Trichomonas vaginalis D-aminoacylase, putative 0.0056 0.0088 0.0137
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0133 0.0231 0.0231
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0635 0.1172 0.1172
Leishmania major hypothetical protein, conserved 0.002 0.002 0.0022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2673 0.4984 0.4984
Onchocerca volvulus 0.2225 0.4145 1
Onchocerca volvulus 0.003 0.0039 0.0095
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0056 0.0088 0.1326
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0635 0.1172 0.2824
Echinococcus multilocularis jumonji domain containing protein 0.0065 0.0105 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0311 0.0565 0.0565
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.001 0.0001 0.0001
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0008 0.0007
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0644 0.1188 0.1188
Giardia lamblia Cathepsin B precursor 0.3391 0.6328 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0044 0.0066 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0635 0.1172 0.1172
Brugia malayi Cathepsin L-like precursor 0.158 0.294 0.294
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0012 0.0016
Leishmania major ATP-dependent phosphofructokinase 0.0089 0.0149 0.0169
Echinococcus granulosus GTP binding nuclear protein Ran 0.0017 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0635 0.1172 0.1849
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0259 0.0259
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.001 0.0001 0.0001
Brugia malayi hypothetical protein 0.0148 0.0259 0.0259
Onchocerca volvulus Cathepsin L homolog 0.2225 0.4145 1
Giardia lamblia Cysteine protease 0.0635 0.1172 0.1849
Plasmodium vivax vivapain-2 0.2225 0.4145 1
Giardia lamblia Cathepsin B precursor 0.0635 0.1172 0.1849
Giardia lamblia Flap structure-specific endonuclease 0.0021 0.0023 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.002 0.0019
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0001 0.0001
Giardia lamblia Cathepsin L-like protease 0.0635 0.1172 0.1849
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0635 0.1172 0.1849
Toxoplasma gondii 6-phosphofructokinase 0.0024 0.0028 0.0041
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0002 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2225 0.4145 1
Onchocerca volvulus 0.2225 0.4145 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0635 0.1172 0.1172
Trypanosoma cruzi major cysteine proteinase, putative 0.3078 0.5741 0.574
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0051 0.0078 0.0088
Schistosoma mansoni cathepsin F (C01 family) 0.2225 0.4145 0.4145
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0058 0.0089
Echinococcus multilocularis dna polymerase eta 0.0064 0.0103 0.0103
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0013 0.0008 0.001
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0089 0.0149 0.6108
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0058
Plasmodium vivax vivapain-3 0.128 0.2377 0.5727
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0635 0.1172 0.1849
Chlamydia trachomatis phosphoglycerate kinase 0.0139 0.0243 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0008 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Trypanosoma brucei phosphoglycerate kinase, putative 0.0051 0.0078 0.0088
Onchocerca volvulus 0.0056 0.0088 0.0213
Schistosoma mansoni 6-phosphofructokinase 0.0089 0.0149 0.0149
Echinococcus granulosus cathepsin l cysteine peptidase 0.2225 0.4145 0.4145
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0635 0.1172 0.1172
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0008 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0311 0.0565 0.0565
Brugia malayi G-protein alpha subunit 0.0013 0.0008 0.0008
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0011 0.0026
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0103 0.0116
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0012 0.0418
Loa Loa (eye worm) hypothetical protein 0.0644 0.1188 0.1188
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0028 0.0035 0.0035
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0009 0.0009
Echinococcus granulosus polycomb protein SCMH1 0.0039 0.0056 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0058
Mycobacterium ulcerans phosphoglycerate kinase 0.0139 0.0243 0.754
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0011
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0008 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0064 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0058 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0015
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0008 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0056 0.0088 0.0088
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0635 0.1172 0.1849
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0091 0.0091
Plasmodium vivax phosphoglycerate kinase, putative 0.0139 0.0243 0.0568
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.128 0.2377 0.2377
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.128 0.2377 0.2377
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0014 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.0149 0.0355
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0044 0.0066 0.0066
Plasmodium falciparum serine repeat antigen 6 0.0635 0.1172 0.2812
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0058 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0044 0.0066 0.0066
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0011 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0018 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.2225 0.4145 0.4144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.2225 0.4145 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0008 0.0008
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0635 0.1172 0.1849
Echinococcus granulosus cathepsin l1 0.158 0.294 0.294
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0635 0.1172 0.1849
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0635 0.1172 0.2813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Schistosoma mansoni hypothetical protein 0.0254 0.0458 0.0458
Toxoplasma gondii PHD-finger domain-containing protein 0.0015 0.0012 0.0016
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.001 0.0001 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.0321 0.0505
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0015
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Loa Loa (eye worm) hypothetical protein 0.0056 0.0088 0.0088
Giardia lamblia Phosphoglycerate kinase 0.0139 0.0243 0.0381
Brugia malayi hypothetical protein 0.002 0.002 0.002
Echinococcus multilocularis phosphoglycerate kinase 1 0.0139 0.0243 0.0243
Echinococcus granulosus histone acetyltransferase MYST2 0.0044 0.0066 0.0066
Toxoplasma gondii phosphofructokinase PFKII 0.0024 0.0028 0.0041
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0015 0.0012 0.0012
Echinococcus granulosus cathepsin l1 0.2225 0.4145 0.4145
Brugia malayi Bromodomain containing protein 0.0049 0.0075 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0148 0.0259 0.0622
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi 6-phosphofructokinase 0.0089 0.0149 0.0149
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0148 0.0259 0.0622
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0321 1
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0051 0.0078 0.0077
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0013 0.0008 0.0008
Echinococcus granulosus microtubule associated protein 2 0.0765 0.1414 0.1414
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Echinococcus multilocularis geminin 0.0254 0.0458 0.0458
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0089 0.0149 0.6108
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.001 0.0001 0.0001
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0635 0.1172 0.2812
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0635 0.1172 0.2813
Schistosoma mansoni jumonji domain containing protein 0.0122 0.0212 0.0212
Trypanosoma brucei phosphoglycerate kinase 0.0139 0.0243 0.0277
Mycobacterium leprae Probable lipase LipE 0.0056 0.0088 0.3607
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0017 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0644 0.1188 0.1188
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0013 0.0008 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0056 0.0088 0.272
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0275 0.0497 0.0497
Leishmania major DNA polymerase eta, putative 0.0064 0.0103 0.0116
Brugia malayi Bloom's syndrome protein homolog 0.002 0.002 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0104 0.0103
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0104 0.0104
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0635 0.1172 0.2813
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0021 0.0023 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.128 0.2377 0.5733
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0017 0.0017
Echinococcus granulosus bloom syndrome protein 0.002 0.002 0.002
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0011 0.0015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0047 0.0071 0.0071
Schistosoma mansoni ap endonuclease 0.0015 0.0012 0.0012
Leishmania major DNA polymerase kappa, putative 0.0013 0.0008 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0008 0.0007
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0021 0.0023 0.0024
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.001 0.0001 0.0001
Echinococcus multilocularis expressed protein 0.0013 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0054
Loa Loa (eye worm) hypothetical protein 0.0064 0.0103 0.0103
Giardia lamblia Cathepsin L precursor 0.0635 0.1172 0.1849
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0008 0.0008
Schistosoma mansoni alkaline phosphatase 0.0133 0.0231 0.0231
Plasmodium falciparum serine repeat antigen 1 0.0635 0.1172 0.2812
Giardia lamblia Cathepsin L precursor 0.0635 0.1172 0.1849
Entamoeba histolytica cysteine proteinase, putative 0.2225 0.4145 1
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0045 0.0045
Toxoplasma gondii preprocathepsin c precursor, putative 0.0635 0.1172 0.1849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0311 0.0565 0.0565
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0028 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0635 0.1172 0.1849
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Giardia lamblia Cathepsin L precursor 0.0635 0.1172 0.1849
Leishmania major phosphoglycerate kinase C, glycosomal 0.0139 0.0243 0.0277
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0097 0.0165 0.0165
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.002 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0036 0.0036
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0011 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0635 0.1172 0.1172
Schistosoma mansoni alpha glucosidase 0.004 0.0058 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.3391 0.6328 1
Schistosoma mansoni hypothetical protein 0.0069 0.0112 0.0112
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0058 0.0089
Loa Loa (eye worm) hypothetical protein 0.0056 0.0088 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0056 0.0088 0.0088
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0021 0.0023 0.0024
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0008 0.001
Trichomonas vaginalis importin beta-1, putative 0.0019 0.0018 0.0027
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0156 0.0276 0.0276
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.0149 0.0355
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0056 0.0088 0.0088
Giardia lamblia DNA damage repair protein 0.0013 0.0008 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0321 1
Brugia malayi hypothetical protein 0.0013 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) mbt repeat family protein 0.0039 0.0056 0.0056
Echinococcus granulosus cysteine protease 0.128 0.2377 0.2377
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0011 0.0008
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0008 0.0008
Brugia malayi phosphofructokinase 0.0089 0.0149 0.0149
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0368 0.0368
Echinococcus multilocularis muscleblind protein 0.0275 0.0497 0.0497
Giardia lamblia DINP protein human, muc B family 0.0049 0.0074 0.0114
Leishmania major cathepsin L-like protease 0.4667 0.8715 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0058 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0011
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0064 0.0064
Schistosoma mansoni sex comb on midleg homolog 0.0039 0.0056 0.0056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0635 0.1172 0.1172
Trypanosoma cruzi major cysteine proteinase, putative 0.0635 0.1172 0.117
Giardia lamblia PHD finger protein 15 0.0047 0.0071 0.011
Trypanosoma cruzi cysteine proteinase, putative 0.128 0.2377 0.2376
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.001 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0058 0.0089
Schistosoma mansoni bromodomain containing protein 0.0052 0.0079 0.0079
Brugia malayi Bromodomain containing protein 0.0061 0.0097 0.0097
Echinococcus multilocularis snurportin 1 0.0251 0.0452 0.0452
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0011 0.0011
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0013 0.0008 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0635 0.1172 0.1849
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0064 0.0951
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.0074 0.0074
Loa Loa (eye worm) bromodomain containing protein 0.0014 0.001 0.001
Entamoeba histolytica Flap nuclease, putative 0.0021 0.0023 0.0051
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0013 0.0008 0.0008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.0271 0.0271
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0635 0.1172 0.1172
Echinococcus multilocularis microtubule associated protein 2 0.0765 0.1414 0.1414
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0017 0.0015 0.0015
Echinococcus granulosus importin subunit beta 1 0.0023 0.0027 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0092 0.0092
Brugia malayi beta-lactamase 0.0056 0.0088 0.0088
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0028 0.0048
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0008 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0311 0.0565 0.0565
Trypanosoma brucei glucosidase, putative 0.004 0.0058 0.0065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0147 0.0258 0.0258
Brugia malayi Papain family cysteine protease containing protein 0.0635 0.1172 0.1172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0066 0.0066
Schistosoma mansoni alpha-glucosidase 0.0155 0.0274 0.0274
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0064 0.0064
Echinococcus granulosus intestinal type alkaline phosphatase 0.0133 0.0231 0.0231
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0001 0.0001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0064 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.0321 0.0321
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.0635 0.1172 0.2824
Toxoplasma gondii PHD-finger domain-containing protein 0.0047 0.0071 0.011
Brugia malayi N-terminal motif family protein 0.0147 0.0258 0.0258
Echinococcus multilocularis cysteine protease 0.2225 0.4145 0.4145
Schistosoma mansoni hypothetical protein 0.0017 0.0014 0.0014
Echinococcus multilocularis polycomb protein SCMH1 0.0039 0.0056 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0104 0.0103
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0321 0.0321
Mycobacterium ulcerans 6-phosphofructokinase 0.0089 0.0149 0.4605
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0008 0.0008
Trypanosoma brucei unspecified product 0.006 0.0094 0.0107
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0012 0.0418
Onchocerca volvulus 0.0056 0.0088 0.0213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0311 0.0565 0.0565
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0011 0.0011
Toxoplasma gondii cathepsin CPC2 0.0635 0.1172 0.1849
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.024 0.0431 0.0431
Echinococcus granulosus cathepsin L 0.0635 0.1172 0.1172
Onchocerca volvulus Cathepsin F homolog 0.2225 0.4145 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Loa Loa (eye worm) hypothetical protein 0.0056 0.0088 0.0088
Mycobacterium ulcerans esterase/lipase LipP 0.0056 0.0088 0.272
Mycobacterium tuberculosis Probable esterase LipL 0.0056 0.0088 0.1326
Entamoeba histolytica cysteine proteinase, putative 0.158 0.294 0.7091
Trypanosoma brucei unspecified product 0.003 0.0039 0.0043
Trypanosoma cruzi cysteine proteinase, putative 0.128 0.2377 0.2376
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0635 0.1172 0.2812
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0104 0.0163
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0013 0.0008 0.001
Leishmania major hypothetical protein, conserved 0.0056 0.0088 0.01
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0089 0.0089
Brugia malayi Flap endonuclease-1 0.0021 0.0023 0.0023
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0028 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.0271 0.0271
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0017 0.0015 0.0016
Trypanosoma cruzi cysteine protease, putative 0.128 0.2377 0.2376
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.002 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0058 0.0065
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0058 0.0089
Schistosoma mansoni ap endonuclease 0.0015 0.0012 0.0012
Echinococcus granulosus dna polymerase kappa 0.0065 0.0104 0.0104
Brugia malayi jmjC domain containing protein 0.0154 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0056
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0038 0.0038
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0058 0.0056
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0051 0.0078 0.0077
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0058 0.0058
Entamoeba histolytica cysteine protease, putative 0.0635 0.1172 0.2824
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0635 0.1172 0.1849
Plasmodium falciparum serine repeat antigen 2 0.0635 0.1172 0.2812
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0015
Leishmania major importin beta-1 subunit, putative 0.0019 0.0018 0.0019
Loa Loa (eye worm) phosphofructokinase 0.0089 0.0149 0.0149
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0011 0.0011
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0012 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0086 0.0145 0.0145
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5354 1 1
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2225 0.4145 0.655
Plasmodium falciparum phosphoglycerate kinase 0.0139 0.0243 0.0567
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0012 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0039 0.006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0012 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2225 0.4145 0.4145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Onchocerca volvulus 0.2225 0.4145 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0635 0.1172 0.1172
Loa Loa (eye worm) hypothetical protein 0.0044 0.0066 0.0066
Brugia malayi cathepsin Z-like cysteine proteinase 0.0635 0.1172 0.1172
Giardia lamblia Cysteine protease 0.0635 0.1172 0.1849
Plasmodium falciparum flap endonuclease 1 0.0021 0.0023 0.0035
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0002 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0028 0.0041
Echinococcus multilocularis peregrin 0.0057 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Mycobacterium leprae conserved hypothetical protein 0.0056 0.0088 0.3607
Entamoeba histolytica cysteine proteinase, putative 0.128 0.2377 0.5733
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0074 0.1104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0056 0.0088 0.0088
Giardia lamblia Cysteine protease 0.0635 0.1172 0.1849
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.3391 0.6328 0.7261
Echinococcus granulosus fetal alzheimer antigen falz 0.0018 0.0017 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0011 0.0015
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0013 0.0008 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0094 0.0107
Echinococcus granulosus zinc finger protein 0.0016 0.0013 0.0013
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0044 0.0066 0.0066
Entamoeba histolytica recQ family helicase, putative 0.001 0.0002 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0321 0.0321
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0635 0.1172 0.2824
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0644 0.1188 0.1188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0635 0.1172 0.1172
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0008 0.0008
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0051 0.0078 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0635 0.1172 0.1172
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0104 0.0118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0007 0.0009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0008 0.0008
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.001 0.0001 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0009 0.0009
Giardia lamblia Cathepsin B precursor 0.0635 0.1172 0.1849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Entamoeba histolytica phosphoglycerate kinase, putative 0.0139 0.0243 0.0582
Trypanosoma cruzi cruzipain precursor, putative 0.0644 0.1188 0.1187
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0139 0.0243 0.0241
Plasmodium falciparum serine repeat antigen 5 0.0635 0.1172 0.2812
Echinococcus granulosus beta LACTamase domain containing family member 0.0056 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0635 0.1172 0.1849
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0149 0.0233
Onchocerca volvulus 0.2225 0.4145 1
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0008 0.0008
Toxoplasma gondii cathepsin CPC1 0.0635 0.1172 0.1849
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0011 0.0011
Echinococcus granulosus GPCR family 2 0.004 0.0058 0.0058
Brugia malayi beta-lactamase family protein 0.0056 0.0088 0.0088
Giardia lamblia Cathepsin B precursor 0.0635 0.1172 0.1849
Plasmodium falciparum serine repeat antigen 8 0.0635 0.1172 0.2812
Treponema pallidum phosphoglycerate kinase 0.0139 0.0243 1
Brugia malayi Cathepsin L-like precursor 0.2225 0.4145 0.4145
Toxoplasma gondii HEAT repeat-containing protein 0.0023 0.0027 0.004
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0008 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0001 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2225 0.4145 0.4145
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.002 0.003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0104 0.0163
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0139 0.0243 0.0241
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0133 0.0231 0.0231
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.002 0.003
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0635 0.1172 0.2824
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0081 0.0134 0.0134
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0421 0.0662
Echinococcus multilocularis PHD finger protein rhinoceros 0.0047 0.0071 0.0071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.4023 0.7509 0.7509
Entamoeba histolytica cysteine proteinase, putative 0.128 0.2377 0.5733
Brugia malayi mbt repeat family protein 0.0039 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) 6-phosphofructokinase 0.0089 0.0149 0.0149
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.5354 1 1
Plasmodium falciparum serine repeat antigen 4 0.0635 0.1172 0.2812
Schistosoma mansoni hypothetical protein 0.0148 0.0259 0.0259
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0254 0.0458 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2225 0.4145 0.4145
Schistosoma mansoni phosphoglycerate kinase 0.0139 0.0243 0.0243
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0058 0.0058
Loa Loa (eye worm) cysteine protease 0.2225 0.4145 0.4145
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0139 0.0243 1
Entamoeba histolytica cysteine proteinase 2 0.128 0.2377 0.5733
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0011 0.0011
Plasmodium vivax SET domain protein, putative 0.003 0.0039 0.0077
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0058
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0048 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.0321 0.0367
Onchocerca volvulus 0.158 0.294 0.7092
Onchocerca volvulus Cathepsin L homolog 0.0635 0.1172 0.2826
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0011 0.0022
Giardia lamblia Cathepsin L precursor 0.0635 0.1172 0.1849
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5354 1 1
Echinococcus granulosus cathepsin L 0.128 0.2377 0.2377
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.128 0.2377 0.2376
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0008 0.001
Echinococcus multilocularis GPCR, family 2 0.004 0.0058 0.0058
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.001 0.0001 0.0001
Onchocerca volvulus 0.0234 0.0421 0.1015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0311 0.0565 0.0565
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0058 0.0089
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0008 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0018 0.0018
Leishmania major DNA polymerase eta, putative 0.0034 0.0047 0.0052
Trypanosoma brucei phosphoglycerate kinase 0.0051 0.0078 0.0088
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0126 0.0219 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5354 1 1
Loa Loa (eye worm) RecQ helicase 0.002 0.002 0.002
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0635 0.1172 0.2813
Brugia malayi cathepsin F-like cysteine proteinase 0.0644 0.1188 0.1188
Brugia malayi Pre-SET motif family protein 0.0206 0.0368 0.0368
Trypanosoma cruzi cysteine peptidase, putative 0.128 0.2377 0.2376
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0635 0.1172 0.2813
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0058 0.0089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0321 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0635 0.1172 0.1849
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0044 0.0066 0.0066
Giardia lamblia Cathepsin B precursor 0.0635 0.1172 0.1849
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.001 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0635 0.1172 0.1849
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0028 0.0035 0.0035
Echinococcus multilocularis cathepsin L 0.0635 0.1172 0.1172
Echinococcus multilocularis cathepsin L cysteine protease 0.2225 0.4145 0.4145
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0008 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0056 0.0088 0.1326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Brugia malayi RNA, U transporter 1 0.0067 0.0108 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0058 0.0056
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0015 0.0012 0.0012
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0008 0.0008
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0092 0.0092
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3391 0.6328 0.6328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.0149 0.0355
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0028 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0635 0.1172 0.1849
Echinococcus multilocularis importin subunit beta 1 0.0023 0.0027 0.0027
Brugia malayi cathepsin L-like precursor 0.158 0.294 0.294
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.128 0.2377 0.2377
Schistosoma mansoni cathepsin S (C01 family) 0.0635 0.1172 0.1172
Loa Loa (eye worm) flap endonuclease-1 0.0021 0.0023 0.0023
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0139 0.0243 0.3676
Schistosoma mansoni alpha-glucosidase 0.0155 0.0274 0.0274
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0056 0.0088 0.1326
Brugia malayi Cathepsin L-like precursor 0.2225 0.4145 0.4145
Brugia malayi cathepsin Z-like cysteine proteinase 0.0635 0.1172 0.1172
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0635 0.1172 0.1849
Entamoeba histolytica hypothetical protein 0.0148 0.0259 0.0622
Giardia lamblia Cathepsin L-like protease 0.0635 0.1172 0.1849
Leishmania major DNA polymerase kappa, putative 0.0049 0.0074 0.0083
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0017 0.0015 0.0018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.0074 0.0074
Echinococcus granulosus betaine aldehyde dehydrogenase 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0635 0.1172 0.1172
Loa Loa (eye worm) hypothetical protein 0.158 0.294 0.294
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0133 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0012
Onchocerca volvulus Alhambra homolog 0.0047 0.0071 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0103 0.0101
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.002 0.0031
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2225 0.4145 0.655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0024 0.0028 0.0041
Leishmania major cysteine peptidase A (CPA) 0.2225 0.4145 0.4756
Brugia malayi Cathepsin L-like precursor 0.2225 0.4145 0.4145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2225 0.4145 0.655
Brugia malayi AF-10 protein 0.0015 0.0012 0.0012
Trichomonas vaginalis flap endonuclease-1, putative 0.0021 0.0023 0.0033
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0013 0.0008 0.0008
Schistosoma mansoni cathepsin C 0.0635 0.1172 0.1172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0635 0.1172 0.1849
Loa Loa (eye worm) cathepsin B 0.3391 0.6328 0.6328
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0038 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0056 0.0088 0.0137
Loa Loa (eye worm) hypothetical protein 0.158 0.294 0.294
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0058 0.0058
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0011 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.0027 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4667 0.8715 1
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0028 0.0041
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0047 0.0045
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0066 0.0066
Schistosoma mansoni zinc finger protein 0.0012 0.0006 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0635 0.1172 0.1172
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0011 0.0015
Schistosoma mansoni SET domain protein 0.0011 0.0004 0.0004
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0011 0.0011
Echinococcus granulosus peregrin 0.0057 0.0089 0.0089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.0321 0.0321
Trypanosoma cruzi cysteine peptidase, putative 0.4667 0.8715 0.8715
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0011 0.0011
Trypanosoma cruzi ISWI complex protein 0.0012 0.0006 0.0005
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0024 0.0028 0.0063
Schistosoma mansoni 6-phosphofructokinase 0.0089 0.0149 0.0149
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0008 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.0765 0.1414 0.1414
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0008 0.0008
Plasmodium vivax importin-beta 2, putative 0.0023 0.0027 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0071 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0054
Giardia lamblia Cathepsin B precursor 0.0635 0.1172 0.1849
Loa Loa (eye worm) beta-lactamase 0.0056 0.0088 0.0088
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0058 0.0089
Onchocerca volvulus 0.0635 0.1172 0.2826
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.5354 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.0321 0.4875
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0635 0.1172 0.1172
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0058 0.0136
Loa Loa (eye worm) G protein alpha subunit 3 0.0013 0.0008 0.0008
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0008 0.0008
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.5354 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Entamoeba histolytica cysteine protease, putative 0.128 0.2377 0.5733
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0635 0.1172 0.1172
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0321 0.0321
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0013 0.0008 0.0008
Brugia malayi hypothetical protein 0.0013 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0635 0.1172 0.2824
Plasmodium vivax unspecified product 0.128 0.2377 0.5727
Trypanosoma brucei unspecified product 0.003 0.0039 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0088 0.0195
Schistosoma mansoni alkaline phosphatase 0.0133 0.0231 0.0231

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) nM Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase ChEMBL. 15081010
IC50 (functional) 0 nM Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase ChEMBL. 15081010
IC50 (binding) = 1100 nM Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand ChEMBL. 15081010
IC50 (binding) = 1100 nM Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand ChEMBL. 15081010

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.