Detailed information for compound 116702

Basic information

Technical information
  • TDR Targets ID: 116702
  • Name: 4-(4-chlorophenyl)-5-[2-(4-phenylpiperazin-1- yl)ethyl]-3H-1,3-oxazol-2-one
  • MW: 383.871 | Formula: C21H22ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 4.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nc(oc1CCN1CCN(CC1)c1ccccc1)O
  • InChi: 1S/C21H22ClN3O2/c22-17-8-6-16(7-9-17)20-19(27-21(26)23-20)10-11-24-12-14-25(15-13-24)18-4-2-1-3-5-18/h1-9H,10-15H2,(H,23,26)
  • InChiKey: GHLFWWUERYGWEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-chlorophenyl)-5-[2-(4-phenylpiperazin-1-yl)ethyl]-3H-oxazol-2-one
  • 4-(4-chlorophenyl)-5-[2-(4-phenyl-1-piperazinyl)ethyl]-3H-oxazol-2-one
  • 4-(4-chlorophenyl)-5-[2-(4-phenylpiperazino)ethyl]-4-oxazolin-2-one
  • 52868-08-3
  • 4-(4-Chlorophenyl)-5-(2-(4-phenyl-1-piperazinyl)ethyl)-2(3H)-oxazolone
  • BRN 1170810
  • 2(3H)-Oxazolone, 4-(4-chlorophenyl)-5-(2-(4-phenyl-1-piperazinyl)ethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0269
Echinococcus granulosus histone deacetylase 6 0.0327 0.3708 0.3707
Loa Loa (eye worm) alpha-tubulin 0.0273 0.3062 0.4377
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0175 0.1406
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0256 0.0254
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0256 0.0363
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Onchocerca volvulus 0.0099 0.0996 0.2271
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0359 0.4088 0.4087
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.0248
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0769 0.1182
Schistosoma mansoni tubulin subunit gamma 0.0205 0.2263 0.2261
Brugia malayi hypothetical protein 0.0166 0.1798 0.2569
Echinococcus granulosus histone acetyltransferase KAT2B 0.0282 0.3172 0.317
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Brugia malayi dihydrofolate reductase family protein 0.0045 0.0351 0.0498
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Onchocerca volvulus 0.0067 0.0619 0.1377
Brugia malayi MH1 domain containing protein 0.0041 0.0308 0.0437
Loa Loa (eye worm) tubulin alpha 2 0.0067 0.0619 0.0882
Plasmodium vivax histone deacetylase 2, putative 0.0302 0.3418 0.5353
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0099 0.0996 0.0994
Brugia malayi Histone deacetylase family protein 0.0302 0.3418 0.4887
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0416 0.0413
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0109 0.0107
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0016
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0175 0.0248
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0256 0.0402
Schistosoma mansoni hypothetical protein 0.007 0.0647 0.0645
Loa Loa (eye worm) hypothetical protein 0.0166 0.1798 0.2569
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1137 0.1762
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.3062 0.306
Brugia malayi 6-phosphofructokinase 0.0111 0.1137 0.1624
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0047 0.0374 0.0372
Schistosoma mansoni lamin 0.0027 0.0146 0.0144
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0038 0.0051
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0147 0.1569 0.1567
Schistosoma mansoni intermediate filament proteins 0.0027 0.0146 0.0144
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0074
Brugia malayi Flap endonuclease-1 0.0027 0.0135 0.019
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Echinococcus granulosus tubulin beta 4A class IVa 0.0359 0.4088 0.4087
Schistosoma mansoni lamin 0.0027 0.0146 0.0144
Schistosoma mansoni alpha tubulin 0.0273 0.3062 0.306
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.0351 0.0498
Brugia malayi histone deacetylase 11 0.0191 0.2095 0.2994
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0393 0.0558
Echinococcus granulosus thyroid hormone receptor alpha 0.0047 0.0374 0.0372
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0329 0.0516
Toxoplasma gondii beta tubulin 0.0359 0.4088 0.6408
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Plasmodium vivax histone deacetylase, putative 0.0191 0.2095 0.3269
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0393 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0293 0.046
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0664 0.1042
Onchocerca volvulus 0.0047 0.0374 0.0798
Echinococcus multilocularis chromobox protein 1 0.0071 0.0664 0.0662
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0769 0.0766
Trypanosoma cruzi epsilon tubulin, putative 0.0205 0.2263 0.3533
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Brugia malayi hypothetical protein 0.0052 0.0441 0.0627
Trypanosoma brucei epsilon tubulin 0.0205 0.2263 0.3533
Toxoplasma gondii exonuclease III APE 0.0019 0.0047 0.0046
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0205 0.2263 0.3533
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus granulosus flap endonuclease 1 0.0027 0.0135 0.0133
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.0351 0.2971
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0454 0.0646
Trypanosoma brucei zeta tubulin, putative 0.0089 0.088 0.1357
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0109 0.0144
Mycobacterium tuberculosis Conserved protein 0.0037 0.0256 0.0918
Echinococcus granulosus histone deacetylase 6 0.0302 0.3418 0.3417
Loa Loa (eye worm) transcription factor SMAD2 0.0603 0.6992 1
Loa Loa (eye worm) alpha-tubulin 0.0273 0.3062 0.4377
Schistosoma mansoni alpha tubulin 0.0273 0.3062 0.306
Brugia malayi hypothetical protein 0.005 0.0417 0.0594
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.5474 0.5472
Leishmania major zeta tubulin, putative 0.0089 0.088 0.1357
Loa Loa (eye worm) tubulin alpha 2 0.0183 0.2001 0.2859
Loa Loa (eye worm) CBP-B 0.0079 0.0757 0.108
Echinococcus granulosus CREB binding protein 0.011 0.1133 0.1131
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0168 0.0236
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.3062 0.4806
Plasmodium vivax glutathione reductase, putative 0.0048 0.0393 0.059
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0256 0.1589
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0189 0.0187
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0441 0.0627
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0175 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0189 0.0187
Plasmodium falciparum histone deacetylase 1 0.0551 0.637 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1273 0.4845
Plasmodium falciparum alpha tubulin 1 0.0273 0.3062 0.4791
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0996 0.1421
Giardia lamblia Gamma tubulin 0.0205 0.2263 0.3533
Plasmodium vivax histone deacetylase, putative 0.0302 0.3418 0.5353
Brugia malayi hypothetical protein 0.0047 0.0374 0.0532
Trichomonas vaginalis tubulin beta chain, putative 0.0116 0.1202 0.1887
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0749 0.111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0024 0.0109 0.0144
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Echinococcus multilocularis beta tubulin 0.0359 0.4088 0.4087
Brugia malayi nuclear receptor NHR-67 0.0047 0.0374 0.0532
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0135 0.0133
Echinococcus multilocularis CREB binding protein 0.0017 0.0021 0.0019
Toxoplasma gondii alpha-tubulin I, putative 0.0273 0.3062 0.4791
Loa Loa (eye worm) histone deacetylase 1 0.0551 0.637 0.9111
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0099 0.0996 0.1421
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Trichomonas vaginalis tubulin alpha chain, putative 0.0116 0.1202 0.1887
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0769 0.1182
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0769 0.1182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0189 0.0187
Trypanosoma cruzi tubulin delta chain 0.0089 0.088 0.1357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0904 0.0902
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0047 0.0262
Trichomonas vaginalis tubulin epsilon chain, putative 0.0359 0.4088 0.6418
Mycobacterium ulcerans hypothetical protein 0.0021 0.0064 0.0409
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0024 0.0109 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0099 0.0996 0.1421
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0016
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0135 0.0184
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0097 0.0136
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.2608 1
Echinococcus granulosus CREB binding protein 0.0017 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0135 0.019
Onchocerca volvulus 0.0027 0.0146 0.0257
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0052 0.0441 0.0439
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1137 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0109 0.0107
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0749 0.5664
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1137 0.1624
Mycobacterium tuberculosis Conserved protein 0.0037 0.0256 0.0918
Echinococcus multilocularis histone deacetylase 6 0.0302 0.3418 0.3417
Loa Loa (eye worm) glutathione reductase 0.0048 0.0393 0.0558
Loa Loa (eye worm) hypothetical protein 0.0033 0.0215 0.0304
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Schistosoma mansoni transcription factor LCR-F1 0.0182 0.1981 0.1979
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0256 0.0363
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0256 0.2125
Echinococcus granulosus histone deacetylase 6 0.0302 0.3418 0.3417
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0064 0.0088
Loa Loa (eye worm) beta-tubulin 0.0359 0.4088 0.5846
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0374 0.0532
Brugia malayi Histone deacetylase 1 0.0551 0.637 0.9111
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1273 0.4845
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0769 0.1182
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0292 0.329 0.3289
Trypanosoma brucei histone deacetylase 3 0.0302 0.3418 0.5353
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.1645 0.235
Schistosoma mansoni tubulin subunit alpha 0.0089 0.088 0.0878
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0256 0.0918
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0182 0.1981 0.1979
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0099 0.0996 0.0994
Schistosoma mansoni tubulin subunit epsilon 0.0205 0.2263 0.2261
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0037 0.0057
Plasmodium vivax tubulin epsilon chain, putative 0.0205 0.2263 0.3533
Echinococcus multilocularis lamin dm0 0.0027 0.0146 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0374 0.0372
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0097 0.0125
Brugia malayi p25-alpha family protein 0.0373 0.4256 0.6085
Echinococcus multilocularis CREB binding protein 0.0017 0.0021 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 0.2154
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi MH2 domain containing protein 0.0018 0.0038 0.0051
Giardia lamblia Beta tubulin 0.0359 0.4088 0.6408
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0189 0.0187
Loa Loa (eye worm) p25-alpha family protein 0.0373 0.4256 0.6085
Brugia malayi tubulin alpha-2 chain 0.0273 0.3062 0.4377
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0024 0.0109 0.0144
Onchocerca volvulus 0.0245 0.2737 0.6399
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.0206
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.0996 0.1421
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0135 0.0139
Schistosoma mansoni hypothetical protein 0.0053 0.0446 0.0444
Mycobacterium tuberculosis Conserved protein 0.0037 0.0256 0.0918
Echinococcus granulosus histone deacetylase 8 0.0191 0.2095 0.2093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0904 0.0902
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.0996 0.0994
Brugia malayi hypothetical protein 0.0052 0.0439 0.0625
Onchocerca volvulus Histone deacetylase 10 homolog 0.0191 0.2095 0.4876
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0664 0.0947
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0018 0.0022
Brugia malayi histone deacetylase 1 (HD1) 0.0551 0.637 0.9111
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Trypanosoma cruzi histone deacetylase, putative 0.0302 0.3418 0.5353
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0051
Echinococcus granulosus tubulin alpha 0.0205 0.2263 0.2261
Brugia malayi Tubulin gamma chain 0.0205 0.2263 0.3234
Loa Loa (eye worm) acetyltransferase 0.0292 0.329 0.4704
Brugia malayi Muscleblind-like protein 0.0152 0.163 0.2329
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0256 0.2125
Onchocerca volvulus 0.0029 0.0168 0.0308
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1346 0.1344
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.1127 0.8793
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0089 0.088 0.1357
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0256 0.0402
Loa Loa (eye worm) hypothetical protein 0.0273 0.3062 0.4377
Echinococcus multilocularis musashi 0.0027 0.0146 0.0144
Brugia malayi beta-lactamase 0.0037 0.0256 0.0363
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0183 0.2001 0.3141
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0097 0.0125
Onchocerca volvulus Protein ultraspiracle homolog 0.0099 0.0996 0.2271
Brugia malayi hypothetical protein 0.0047 0.0374 0.0532
Echinococcus multilocularis CREB binding protein 0.0078 0.0747 0.0744
Entamoeba histolytica tubulin alpha chain, putative 0.0273 0.3062 0.4767
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Giardia lamblia Epsilon tubulin 0.0089 0.088 0.1357
Schistosoma mansoni histone deacetylase 4 5 0.0302 0.3418 0.3417
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0135 0.0212
Leishmania major cytochrome p450-like protein 0.0023 0.0097 0.0125
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0175 0.0275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Echinococcus multilocularis peroxisome assembly protein 26 0.0273 0.3062 0.306
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.0248
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0024 0.0109 0.0107
Echinococcus granulosus cpg binding protein 0.0031 0.0187 0.0185
Schistosoma mansoni chromobox protein 0.0071 0.0664 0.0662
Brugia malayi nuclear hormone receptor 0.0099 0.0996 0.1421
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Brugia malayi MH1 domain containing protein 0.0023 0.009 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0256 0.0374
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0256 0.0918
Echinococcus multilocularis thyroid hormone receptor alpha 0.0227 0.2522 0.252
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0749 0.115
Brugia malayi phosphofructokinase 0.0111 0.1137 0.1624
Schistosoma mansoni nuclear receptor 0.0047 0.0374 0.0372
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0038 0.0035
Trypanosoma cruzi histone deacetylase 1, putative 0.0551 0.637 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0417 0.0629
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Schistosoma mansoni RAR-like nuclear receptor 0.0099 0.0996 0.0994
Trypanosoma cruzi histone deacetylase, putative 0.0302 0.3418 0.5353
Trypanosoma brucei zeta tubulin 0.0089 0.088 0.1357
Schistosoma mansoni cpg binding protein 0.0029 0.0168 0.0165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.0996 0.1421
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 0.2154
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0135 0.0184
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.3062 0.306
Schistosoma mansoni smad1 5 8 and 0.0041 0.0308 0.0306
Trypanosoma brucei beta tubulin 0.0205 0.2263 0.3533
Onchocerca volvulus 0.0037 0.0256 0.0517
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Schistosoma mansoni smad1 5 8 and 0.0041 0.0308 0.0306
Schistosoma mansoni tubulin subunit delta 0.0089 0.088 0.0878
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0374 0.0798
Mycobacterium ulcerans endonuclease IV 0.0078 0.0749 0.6528
Echinococcus multilocularis histone deacetylase 6 0.0302 0.3418 0.3417
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0099 0.0996 0.1421
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0099 0.0996 0.0994
Mycobacterium tuberculosis Probable reductase 0.011 0.1127 0.4282
Mycobacterium tuberculosis Hypothetical protein 0.0052 0.0439 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0099 0.0996 0.1421
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0047 0.0374 0.0532
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0047 0.0064
Loa Loa (eye worm) hypothetical protein 0.005 0.0417 0.0594
Echinococcus granulosus histone deacetylase 1 0.0551 0.637 0.637
Toxoplasma gondii alpha tubulin TUBA1 0.0273 0.3062 0.4791
Echinococcus multilocularis tubulin delta chain 0.0089 0.088 0.0878
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0135 0.0184
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0047 0.0374 0.0372
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0769 0.1182
Trypanosoma brucei histone deacetylase 2 0.0191 0.2095 0.3269
Echinococcus multilocularis beta tubulin 0.0359 0.4088 0.4087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Echinococcus granulosus single minded 2 0.0037 0.0256 0.0254
Loa Loa (eye worm) nuclear hormone receptor 0.0047 0.0374 0.0532
Echinococcus granulosus smad 0.0041 0.0308 0.0306
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0175 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0227 0.2522 0.252
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0099 0.0996 0.0994
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0046
Brugia malayi steroid hormone receptor 0.0099 0.0996 0.1421
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0256 0.2125
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Mycobacterium tuberculosis Cell division protein FtsZ 0.0089 0.088 0.3329
Trypanosoma cruzi histone deacetylase, putative 0.0191 0.2095 0.3269
Onchocerca volvulus 0.0037 0.0262 0.0532
Trypanosoma cruzi tubulin delta chain 0.0089 0.088 0.1357
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0018 0.0028
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0097 0.0708
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.0996 0.1421
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0018 0.0028
Brugia malayi alpha-tubulin 0.0273 0.3062 0.4377
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0109 0.0144
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0047 0.0374 0.0372
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.0996 0.1421
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0064 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0099 0.0996 0.1421
Onchocerca volvulus 0.0043 0.0327 0.0686
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.3062 0.4377
Trichomonas vaginalis tubulin gamma chain, putative 0.0359 0.4088 0.6418
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1137 0.1135
Trypanosoma brucei histone deacetylase, putative 0.0302 0.3418 0.5353
Giardia lamblia Alpha-tubulin 0.0273 0.3062 0.4791
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Echinococcus granulosus tubulin gamma 1 chain 0.0205 0.2263 0.2261
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1273 0.4845
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Trichomonas vaginalis esterase, putative 0.0037 0.0256 0.0402
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Toxoplasma gondii histone deacetylase HDAC5 0.0191 0.2095 0.3269
Echinococcus multilocularis histone deacetylase 0.0302 0.3418 0.3417
Echinococcus granulosus chromobox protein 1 0.0071 0.0664 0.0662
Echinococcus granulosus tumor protein p63 0.0344 0.3916 0.3914
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0551 0.637 1
Schistosoma mansoni histone deacetylase hda2 0.0327 0.3708 0.3707
Toxoplasma gondii histone deacetylase HDAC3 0.0551 0.637 1
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Loa Loa (eye worm) BEN-1 protein 0.0359 0.4088 0.5846
Echinococcus granulosus muscleblind protein 0.0152 0.163 0.1628
Trypanosoma brucei epsilon tubulin 0.0205 0.2263 0.3533
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0116 0.1202 0.1887
Echinococcus multilocularis histone deacetylase 7 0.0302 0.3418 0.3417
Trypanosoma cruzi epsilon tubulin, putative 0.0205 0.2263 0.3533
Schistosoma mansoni Smad4 0.0041 0.0308 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0256 0.0402
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0109 0.0153
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Loa Loa (eye worm) tubulin alpha-3 chain 0.0156 0.1679 0.2399
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.0996 0.1421
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0109 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.0099 0.0996 0.0994
Echinococcus multilocularis tubulin gamma 1 chain 0.0205 0.2263 0.2261
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Brugia malayi hypothetical protein 0.0052 0.0441 0.0627
Echinococcus granulosus lamin dm0 0.0027 0.0146 0.0144
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1127 0.4282
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Brugia malayi Pre-SET motif family protein 0.0031 0.0189 0.0267
Trypanosoma cruzi histone deacetylase, putative 0.0302 0.3418 0.5353
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0064 0.0409
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Echinococcus multilocularis tubulin subunit TubB 0.0273 0.3062 0.306
Giardia lamblia Hypothetical protein 0.0024 0.0109 0.0144
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0109 0.0153
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0256 0.0402
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Echinococcus multilocularis thymidylate synthase 0.0109 0.1122 0.112
Loa Loa (eye worm) Smad1 0.0041 0.0308 0.0437
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0417 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0439 0.0689
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0024 0.0109 0.0098
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0099 0.0996 0.0994
Loa Loa (eye worm) hypothetical protein 0.0152 0.163 0.2329
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi nuclear hormone receptor family member nhr-6 0.0047 0.0374 0.0532
Trichomonas vaginalis tubulin epsilon chain, putative 0.0089 0.088 0.1382
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0168 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0099 0.0996 0.1421
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0256 0.0254
Schistosoma mansoni thyroid hormone receptor 0.0227 0.2522 0.252
Treponema pallidum cell division protein FtsZ 0.0089 0.088 0.7704
Brugia malayi follicle stimulating hormone receptor 0.0241 0.2685 0.3838
Echinococcus granulosus neuropeptide s receptor 0.0475 0.5474 0.5472
Schistosoma mansoni histone deacetylase 4 5 0.0302 0.3418 0.3417
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1137 0.4321
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0374 0.0532
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0099 0.0996 0.1421
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1127 0.4282
Brugia malayi Pre-SET motif family protein 0.0213 0.235 0.3359
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0175 0.0248
Schistosoma mansoni nuclear hormone receptor 0.0099 0.0996 0.0994
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0329 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0099 0.0996 0.1421
Echinococcus granulosus peroxisome assembly protein 26 0.0273 0.3062 0.306
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.3062 0.4806
Loa Loa (eye worm) histone deacetylase 0.0302 0.3418 0.4887
Echinococcus granulosus Smad4 0.0041 0.0308 0.0306
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0109 0.0153
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0393 0.059
Trichomonas vaginalis tubulin, putative 0.0089 0.088 0.1382
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0074
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0049 0.0398 0.0565
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0855 0.1343
Brugia malayi TAZ zinc finger family protein 0.011 0.1133 0.1617
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0308 0.0437
Giardia lamblia Histone deacetylase 0.0551 0.637 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0205 0.2263 0.3552
Brugia malayi Dihydrofolate reductase 0.0045 0.0351 0.0498
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0047 0.0374 0.0372
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0099 0.0996 0.0994
Schistosoma mansoni hypothetical protein 0.0023 0.0088 0.0085
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0417 0.0629
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.0351 0.0348
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0826 0.965 0.965
Brugia malayi bZIP transcription factor family protein 0.0086 0.0837 0.1195
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1137 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.088 0.1382
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0052 0.0439 0.0663
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0045
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0099 0.0996 0.0994
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0374 0.0372
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Loa Loa (eye worm) histone deacetylase 3 0.0551 0.637 0.9111
Brugia malayi tailless protein 0.0047 0.0374 0.0532
Brugia malayi MH2 domain containing protein 0.0041 0.0308 0.0437
Onchocerca volvulus 0.0242 0.2699 0.6308
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.1122 0.1601
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0089 0.088 0.1382
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0308 0.0306
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0052 0.0441 0.0439
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1137 0.1723
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0016
Schistosoma mansoni jun-related protein 0.007 0.0647 0.0645
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1273 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0024 0.0109 0.0144
Plasmodium falciparum flap endonuclease 1 0.0027 0.0135 0.0184
Echinococcus granulosus nuclear receptor nhr 48 0.0047 0.0374 0.0372
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0855 0.1318
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0855 0.1318
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Echinococcus granulosus tubulin epsilon chain 0.0205 0.2263 0.2261
Trichomonas vaginalis tubulin alpha chain, putative 0.0116 0.1202 0.1887
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0125
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus granulosus chromobox protein 1 0.0071 0.0664 0.0662
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0024 0.0109 0.0107
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0024 0.0109 0.0153
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.011 0.1133 0.1131
Brugia malayi tubulin alpha chain - mouse 0.0273 0.3062 0.4377
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Plasmodium falciparum tubulin delta chain, putative 0.0089 0.088 0.1357
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0109 0.0144
Echinococcus granulosus lamin 0.0027 0.0146 0.0144
Leishmania major histone deacetylase, putative 0.0302 0.3418 0.5353
Loa Loa (eye worm) hypothetical protein 0.0111 0.1143 0.1632
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.3062 0.306
Onchocerca volvulus 0.0031 0.0191 0.0362
Brugia malayi nuclear receptor RXR 0.0052 0.0441 0.0627
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.3062 0.4791
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0256 0.0918
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0256 0.0254
Brugia malayi nuclear receptor NHR-88 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0417 0.0629
Echinococcus multilocularis muscleblind protein 1 0.0152 0.163 0.1628
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0109 0.0144
Echinococcus granulosus CREB binding protein 0.0017 0.0021 0.0019
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0749 0.2821
Brugia malayi beta-tubulin, identical 0.0359 0.4088 0.5846
Trypanosoma brucei tubulin delta chain 0.0089 0.088 0.1357
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0089 0.088 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0099 0.0996 0.1421
Trypanosoma cruzi histone deacetylase 1, putative 0.0551 0.637 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0146 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0904 0.0902
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.1128 0.161
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0769 0.0766
Loa Loa (eye worm) nuclear factor I 0.0023 0.009 0.0125
Loa Loa (eye worm) hypothetical protein 0.0183 0.2001 0.2859
Onchocerca volvulus 0.0116 0.1202 0.2759
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1137 0.1135
Trichomonas vaginalis tubulin gamma chain, putative 0.0089 0.088 0.1382
Schistosoma mansoni histone deacetylase 0.0551 0.637 0.637
Echinococcus granulosus dihydrofolate reductase 0.0045 0.0351 0.0348
Toxoplasma gondii endonuclease IV APN 0.0078 0.0749 0.115
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi intermediate filament protein 0.0027 0.0146 0.0206
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0046
Echinococcus multilocularis muscleblind protein 0.0152 0.163 0.1628
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1127 0.4282
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Onchocerca volvulus 0.0037 0.0256 0.0517
Brugia malayi hypothetical protein 0.0182 0.1981 0.2831
Brugia malayi Tubulin beta chain 0.0089 0.088 0.1256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0904 0.0902
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0417 0.0629
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0256 0.0374
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0571 0.0569
Leishmania major hypothetical protein, conserved 0.0024 0.0109 0.0144
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Schistosoma mansoni alpha tubulin 0.0273 0.3062 0.306
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1137 0.1723
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Brugia malayi ecdysteroid receptor 0.0099 0.0996 0.1421
Echinococcus multilocularis chromobox protein 1 0.0071 0.0664 0.0662
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0109 0.0153
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.3062 0.306
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.0248
Brugia malayi orphan nuclear receptor NR2E1 0.0047 0.0374 0.0532
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.0769 0.1182
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0097 0.0136
Trypanosoma cruzi zeta tubulin, putative 0.0089 0.088 0.1357
Entamoeba histolytica tubulin alpha-1 chain 0.0273 0.3062 0.4767
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Histone deacetylase family protein 0.0302 0.3418 0.4887
Brugia malayi MH2 domain containing protein 0.0041 0.0308 0.0437
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0038 0.0035
Schistosoma mansoni histone deacetylase hda2 0.0191 0.2095 0.2093
Trichomonas vaginalis tubulin, putative 0.0116 0.1202 0.1887
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0374 0.0372
Brugia malayi nuclear receptor NHR-88 0.0099 0.0996 0.1421
Brugia malayi Cytochrome P450 family protein 0.0023 0.0097 0.0136
Loa Loa (eye worm) hypothetical protein 0.0136 0.1433 0.2046
Leishmania major delta tubulin, putative 0.0089 0.088 0.1357
Loa Loa (eye worm) BEN-1 protein 0.0359 0.4088 0.5846
Entamoeba histolytica tubulin family protein 0.0359 0.4088 0.6391
Schistosoma mansoni tubulin subunit beta 0.0089 0.088 0.0878
Echinococcus multilocularis cpg binding protein 0.0031 0.0187 0.0185
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0089 0.088 0.1357
Loa Loa (eye worm) DR-78 0.0047 0.0374 0.0532
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0109 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0099 0.0996 0.1421
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0052 0.0441 0.0439
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0038 0.0051
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0292 0.329 0.3289
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0024 0.0109 0.0107
Onchocerca volvulus 0.005 0.0419 0.0904
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.2737 0.3913
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0109 0.0153
Entamoeba histolytica tubulin family protein 0.0359 0.4088 0.6391
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0664 0.1042
Mycobacterium ulcerans thymidylate synthase 0.0109 0.1122 0.9865
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.5474 0.5472
Leishmania major trypanothione reductase 0.0048 0.0393 0.059
Brugia malayi Cytochrome P450 family protein 0.0023 0.0097 0.0136
Schistosoma mansoni histone deacetylase 0.0551 0.637 0.637
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0308 0.0306
Echinococcus granulosus tubulin subunit TubB 0.0273 0.3062 0.306
Echinococcus multilocularis CREB binding protein 0.0017 0.0021 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0024 0.0109 0.0098
Brugia malayi MH1 domain containing protein 0.0041 0.0308 0.0437
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0047 0.0046
Brugia malayi Thioredoxin reductase 0.0048 0.0393 0.0558
Echinococcus granulosus histone deacetylase 0.0302 0.3418 0.3417
Leishmania major histone deacetylase, putative 0.0551 0.637 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0769 0.1182
Entamoeba histolytica histone deacetylase, putative 0.0551 0.637 1
Trypanosoma cruzi alpha tubulin, putative 0.0273 0.3062 0.4791
Schistosoma mansoni smad 0.0018 0.0038 0.0035
Brugia malayi Tubulin beta chain 0.0116 0.1202 0.1716
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0099 0.0996 0.0994
Echinococcus multilocularis lamin 0.0027 0.0146 0.0144
Chlamydia trachomatis endonuclease IV 0.0078 0.0749 1
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1137 0.1723
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0855 0.0853
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.235 0.3359
Schistosoma mansoni nuclear receptor nhr-48 0.0047 0.0374 0.0372
Trichomonas vaginalis tubulin gamma chain, putative 0.0205 0.2263 0.3552
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0024 0.0109 0.0144
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0749 0.1068
Schistosoma mansoni nuclear receptor 0.0047 0.0374 0.0372
Trichomonas vaginalis tubulin, putative 0.0116 0.1202 0.1887
Schistosoma mansoni smad 0.0041 0.0308 0.0306
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0183 0.2001 0.2859
Echinococcus multilocularis Smad4 0.0041 0.0308 0.0306
Echinococcus granulosus thymidylate synthase 0.0109 0.1122 0.112
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.2685 0.3838
Trypanosoma brucei trypanothione reductase 0.0048 0.0393 0.059
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0393 0.059
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0135 0.0184
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.3062 0.306
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0185
Brugia malayi conserved hypotetical protein 0.0047 0.0374 0.0532
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0047 0.0045
Brugia malayi nuclear hormone receptor 0.0047 0.0374 0.0532
Giardia lamblia Beta tubulin 0.0359 0.4088 0.6408
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Leishmania major histone deacetylase, putative 0.0302 0.3418 0.5353
Mycobacterium ulcerans cell division protein FtsZ 0.0089 0.088 0.7704
Plasmodium vivax delta tubulin, putative 0.0089 0.088 0.1357
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0199 0.2191 0.2189
Echinococcus granulosus ecdysone induced protein 78C 0.0099 0.0996 0.0994
Loa Loa (eye worm) beta-lactamase 0.0037 0.0256 0.0363
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0045
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Echinococcus multilocularis tubulin beta 1 chain 0.0359 0.4088 0.4087
Trichomonas vaginalis brca1-associated protein, putative 0.0024 0.0109 0.0172
Brugia malayi ecdysone receptor 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Echinococcus multilocularis tubulin epsilon chain 0.0205 0.2263 0.2261
Echinococcus granulosus beta tubulin 0.0359 0.4088 0.4087
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0308 0.0306
Echinococcus multilocularis tumor protein p63 0.0344 0.3916 0.3914
Schistosoma mansoni single-minded 0.005 0.0409 0.0407
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0749 0.115
Echinococcus granulosus beta tubulin 0.0359 0.4088 0.4087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0598 0.0914
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.3062 0.306
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Brugia malayi nuclear receptor RXR 0.0047 0.0374 0.0532
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.0351 0.4552
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Toxoplasma gondii histone deacetylase HDAC4 0.0191 0.2095 0.3269
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0243
Brugia malayi Smad1 0.0041 0.0308 0.0437
Schistosoma mansoni tubulin subunit alpha 0.0273 0.3062 0.306
Entamoeba histolytica tubulin gamma chain 0.0205 0.2263 0.3503
Brugia malayi glutathione reductase 0.0048 0.0393 0.0558
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.3062 0.306
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0099 0.0996 0.0994
Schistosoma mansoni coup transcription factor 0.0099 0.0996 0.0994
Mycobacterium leprae Probable lipase LipE 0.0037 0.0256 0.1589
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0769 0.1096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0047 0.034
Plasmodium vivax histone deacetylase 1, putative 0.0551 0.637 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0749 0.1151
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1137 0.1762
Trichomonas vaginalis BRCA1-associated protein, putative 0.0024 0.0109 0.0172
Mycobacterium ulcerans beta-lactamase 0.0037 0.0256 0.2125
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1127 0.4282
Leishmania major hypothetical protein, conserved 0.0037 0.0256 0.0374
Toxoplasma gondii beta-1 tubulin, putative 0.0359 0.4088 0.6408
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0047 0.0045
Schistosoma mansoni histone deacetylase 1 2 3 0.0191 0.2095 0.2093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0099 0.0996 0.2271
Trypanosoma brucei histone deacetylase 1 0.0551 0.637 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0374 0.0372
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0047 0.0064
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0855 0.1343
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.3062 0.306
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0256 0.0363
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0256 0.0918
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0256 0.0918
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0109 0.1122 0.4263
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0189 0.0187
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0086 0.0837 0.0835
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0045 0.0351 0.2372
Loa Loa (eye worm) nuclear receptor NHR-67 0.0047 0.0374 0.0532
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0109 0.1122 0.8752
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Loa Loa (eye worm) tubulin alpha 2 0.0183 0.2001 0.2859
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0267
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0185
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0769 0.1182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Trichomonas vaginalis tubulin alpha chain, putative 0.0116 0.1202 0.1887
Echinococcus multilocularis smad 0.0041 0.0308 0.0306
Brugia malayi CXXC zinc finger family protein 0.0029 0.0168 0.0236
Echinococcus granulosus transcription factor eb 0.011 0.1128 0.1126
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0135 0.0184
Schistosoma mansoni smad1 5 8 and 0.0041 0.0308 0.0306
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0038 0.0051
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0749 0.1151
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0855 0.1318
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.0248
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0088 0.0085
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1137 0.8877
Brugia malayi histone deacetylase 3 (HD3) 0.0551 0.637 0.9111
Trypanosoma brucei alpha tubulin, putative 0.0116 0.1202 0.1863
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trichomonas vaginalis tubulin alpha chain, putative 0.0359 0.4088 0.6418
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1137 0.1135
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Plasmodium vivax SET domain protein, putative 0.0031 0.0189 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Echinococcus granulosus CREB binding protein 0.0071 0.0662 0.066
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Schistosoma mansoni hypothetical protein 0.0856 1 1
Trichomonas vaginalis tubulin, putative 0.0359 0.4088 0.6418
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.3062 0.306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0904 0.0902
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0109 0.0153
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0099 0.0996 0.0994
Brugia malayi 6-phosphofructokinase 0.0111 0.1137 0.1624
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0086 0.0837 0.0835
Loa Loa (eye worm) hypothetical protein 0.0083 0.081 0.1155
Brugia malayi thymidylate synthase 0.0109 0.1122 0.1602
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0441 0.0627
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0099 0.0996 0.1421
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0327 0.0325
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0154 0.1653 0.2574
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.3062 0.4377
Brugia malayi isocitrate dehydrogenase 0.008 0.0769 0.1096
Schistosoma mansoni hypothetical protein 0.0856 1 1
Echinococcus granulosus tubulin subunit beta 0.0359 0.4088 0.4087
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.3062 0.306
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0109 0.1122 0.112
Brugia malayi Heterochromatin protein 1 0.0071 0.0664 0.0947
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0156 0.1679 0.2636
Onchocerca volvulus 0.0037 0.0256 0.0517
Brugia malayi Pax transcription factor protein 2 0.0245 0.2737 0.3913
Mycobacterium ulcerans epimerase 0.0021 0.0064 0.0409
Schistosoma mansoni hypothetical protein 0.0182 0.1981 0.1979
Brugia malayi chromobox protein homolog 3 0.004 0.0293 0.0416
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.3062 0.4791
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0329 0.069
Loa Loa (eye worm) hypothetical protein 0.0191 0.2095 0.2994
Trypanosoma brucei histone deacetylase 4 0.0302 0.3418 0.5353
Trypanosoma cruzi histone deacetylase, putative 0.0191 0.2095 0.3269
Schistosoma mansoni dihydrofolate reductase 0.0045 0.0351 0.0348
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2699 0.4236
Brugia malayi hypothetical protein 0.0032 0.0205 0.0291
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0393 0.039
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0097 0.0136
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Leishmania major hypothetical protein, conserved 0.0024 0.0109 0.0144
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1346 0.1344
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0398 0.0565
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0256 0.0254
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0551 0.637 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0099 0.0996 0.0994
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0215 0.0304
Loa Loa (eye worm) histone deacetylase 11 0.0191 0.2095 0.2994
Loa Loa (eye worm) hypothetical protein 0.0048 0.0396 0.0564
Echinococcus multilocularis nuclear receptor nhr 48 0.0047 0.0374 0.0372
Plasmodium falciparum histone deacetylase, putative 0.0302 0.3418 0.5353
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1137 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1127 0.4282
Giardia lamblia Beta tubulin 0.0359 0.4088 0.6408
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Cytochrome P450 family protein 0.0053 0.0454 0.0646
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0099 0.0996 0.0994
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0037 0.0057
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0038 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0769 0.0766
Plasmodium falciparum tubulin beta chain 0.0359 0.4088 0.6408
Brugia malayi nuclear hormone receptor family member odr-7 0.0047 0.0374 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0293 0.046
Toxoplasma gondii histone deacetylase HDAC2 0.0551 0.637 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0099 0.0996 0.1421
Plasmodium falciparum alpha tubulin 2 0.0273 0.3062 0.4791
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Brugia malayi BRCA1-associated protein 2 containing protein 0.0024 0.0109 0.0153
Trichomonas vaginalis tubulin alpha chain, putative 0.0205 0.2263 0.3552
Brugia malayi Tubulin alpha-2 chain 0.0273 0.3062 0.4377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0904 0.1291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0904 0.1291
Echinococcus multilocularis transcription factor eb 0.011 0.1128 0.1126
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0551 0.637 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0205 0.2263 0.3533
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0417 0.0629
Loa Loa (eye worm) hypothetical protein 0.0109 0.1122 0.1601
Loa Loa (eye worm) tubulin beta-2A chain 0.0359 0.4088 0.5846
Trypanosoma cruzi zeta tubulin, putative 0.0089 0.088 0.1357
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0256 0.0254
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0273 0.3062 0.4806
Loa Loa (eye worm) tubulin beta chain 0.0089 0.088 0.1256
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0064 0.0061
Brugia malayi hypoxia-induced factor 1 0.0153 0.1645 0.235
Mycobacterium leprae cell division protein FtsZ 0.0089 0.088 0.6752
Echinococcus multilocularis geminin 0.0856 1 1
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0088 0.0085
Schistosoma mansoni retinoic acid receptor RXR 0.0199 0.2191 0.2189
Loa Loa (eye worm) tubulin alpha-2 chain 0.0273 0.3062 0.4377
Echinococcus granulosus jun protein 0.0086 0.0837 0.0835
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0038 0.0035
Loa Loa (eye worm) thymidylate synthase 0.0109 0.1122 0.1602
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0146 0.0206
Echinococcus granulosus BRCA1 associated protein 0.0024 0.0109 0.0107
Loa Loa (eye worm) histone deacetylase 7A 0.0302 0.3418 0.4887
Onchocerca volvulus 0.0047 0.0374 0.0798
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) tubulin beta chain 0.0359 0.4088 0.5846
Trypanosoma brucei tubulin gamma chain 0.0205 0.2263 0.3533
Echinococcus multilocularis BRCA1 associated protein 0.0024 0.0109 0.0107
Trichomonas vaginalis tubulin beta chain, putative 0.0359 0.4088 0.6418
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0175 0.0248
Echinococcus granulosus intermediate filament protein 0.0027 0.0146 0.0144
Brugia malayi Isocitrate dehydrogenase 0.008 0.0769 0.1096
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.3062 0.306
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0099 0.0996 0.0994
Onchocerca volvulus 0.0027 0.0146 0.0257
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0099 0.0996 0.1421
Brugia malayi Tubulin alpha-2 chain 0.0273 0.3062 0.4377
Plasmodium falciparum glutathione reductase 0.0048 0.0393 0.059
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0308 0.0306
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Brugia malayi beta-lactamase family protein 0.0037 0.0256 0.0363
Plasmodium falciparum thioredoxin reductase 0.0048 0.0393 0.059
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.0351 0.1284
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0308 0.0306
Leishmania major histone deacetylase, putative 0.0551 0.637 1
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Loa Loa (eye worm) MH2 domain-containing protein 0.0603 0.6992 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0359 0.4088 0.5846
Toxoplasma gondii ABC1 family protein 0.0037 0.0256 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0256 0.0374
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Brugia malayi beta-lactamase family protein 0.0037 0.0256 0.0363
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus granulosus histone deacetylase 3 0.0551 0.637 0.637
Giardia lamblia Delta tubulin 0.0089 0.088 0.1357
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0904 0.0902
Brugia malayi Tubulin alpha chain 0.0273 0.3062 0.4377
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0308 0.0437
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0189 0.0269
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0551 0.637 0.9111
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0256 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0996 0.1421
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0109 0.0107
Plasmodium falciparum histone deacetylase 2 0.0302 0.3418 0.5353
Echinococcus granulosus tubulin beta 1 chain 0.0359 0.4088 0.4087
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0197
Loa Loa (eye worm) hypothetical protein 0.005 0.0419 0.0596
Echinococcus multilocularis histone deacetylase 8 0.0191 0.2095 0.2093
Echinococcus granulosus tubulin delta chain 0.0089 0.088 0.0878
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.088 0.1382
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Echinococcus granulosus FTZ F1 alpha 0.0099 0.0996 0.0994
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0293 0.0605
Plasmodium vivax tubulin gamma chain, putative 0.0205 0.2263 0.3533
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0097 0.0125
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Tubulin alpha chain 0.0089 0.088 0.1256
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0024 0.0109 0.0169
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1137 0.1624
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0769 0.2898
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Trichomonas vaginalis tubulin epsilon chain, putative 0.0359 0.4088 0.6418
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0109 0.0107
Schistosoma mansoni Smad4 0.0018 0.0038 0.0035
Brugia malayi Cell division protein ftsZ 0.0089 0.088 0.1256
Loa Loa (eye worm) steroid hormone receptor 0.0099 0.0996 0.1421
Brugia malayi hypothetical protein 0.0067 0.0619 0.0882
Leishmania major gamma-tubulin 0.0205 0.2263 0.3533
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0256 0.0918
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1137 0.1762
Echinococcus multilocularis histone deacetylase 6 0.0327 0.3708 0.3707
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0441 0.0439
Brugia malayi PAS domain containing protein 0.005 0.0409 0.0582
Onchocerca volvulus 0.0109 0.1122 0.257
Schistosoma mansoni Smad4 0.0018 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0156 0.1679 0.2399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0099 0.0996 0.1421
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Echinococcus multilocularis hypothetical protein 0.0273 0.3062 0.306
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0256 0.0918
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0024 0.0109 0.0098
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0419 0.0417
Schistosoma mansoni tubulin subunit alpha 0.0273 0.3062 0.306
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0182 0.1981 0.1979
Plasmodium vivax tubulin beta chain, putative 0.0359 0.4088 0.6408
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Leishmania major epsilon tubulin, putative 0.0205 0.2263 0.3533
Loa Loa (eye worm) hypothetical protein 0.004 0.0293 0.0416
Echinococcus multilocularis tubulin subunit beta 0.0359 0.4088 0.4087
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0135 0.0184
Plasmodium falciparum tubulin gamma chain 0.0205 0.2263 0.3533
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1137 0.1624
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.5474 0.5472
Mycobacterium ulcerans hypothetical protein 0.0037 0.0256 0.2125
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Schistosoma mansoni CREB-binding protein 2 0.011 0.1133 0.1131
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0052 0.0441 0.0627
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0189 0.0187
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Giardia lamblia Alpha-tubulin 0.0273 0.3062 0.4791
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0769 0.1182
Echinococcus multilocularis jun protein 0.0086 0.0837 0.0835
Brugia malayi Tubulin beta-1 chain 0.0359 0.4088 0.5846
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0243
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0398 0.0565
Loa Loa (eye worm) tubulin beta-1 chain 0.0359 0.4088 0.5846
Loa Loa (eye worm) hypothetical protein 0.0152 0.163 0.2329
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0047 0.0113
Loa Loa (eye worm) hypothetical protein 0.0078 0.0749 0.1068
Brugia malayi acetyltransferase, GNAT family protein 0.0292 0.329 0.4704
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0146 0.0206
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0047 0.0262
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.3062 0.306
Schistosoma mansoni chromobox protein 0.0071 0.0664 0.0662
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0024 0.0109 0.0153
Trypanosoma brucei epsilon tubulin 0.0205 0.2263 0.3533
Brugia malayi MH1 domain containing protein 0.0023 0.009 0.0125
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Onchocerca volvulus TPPP family protein homolog 0.0373 0.4256 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0256 0.2125
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.3062 0.306
Brugia malayi Steroid receptor seven-up type 2 0.0099 0.0996 0.1421
Schistosoma mansoni hypothetical protein 0.0128 0.1346 0.1344
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0374 0.0798
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0088
Echinococcus multilocularis histone deacetylase 3 0.0551 0.637 0.637
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.0212
Schistosoma mansoni zinc finger protein 0.0047 0.0374 0.0372
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0024 0.0109 0.0144
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0046
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.3062 0.306
Onchocerca volvulus Bile acid receptor homolog 0.0099 0.0996 0.2271
Schistosoma mansoni flap endonuclease-1 0.0024 0.0105 0.0102
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0047 0.0046
Toxoplasma gondii beta-tubulin, putative 0.0359 0.4088 0.6408
Echinococcus multilocularis ecdysone induced protein 78C 0.0099 0.0996 0.0994
Echinococcus multilocularis tubulin alpha 0.0205 0.2263 0.2261
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0904 0.0902
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0099 0.0996 0.1421
Echinococcus multilocularis histone deacetylase 1 0.0551 0.637 0.637
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0398 0.0565
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0393 0.039
Echinococcus granulosus histone deacetylase 7 0.0302 0.3418 0.3417
Echinococcus granulosus alpha tubulin 0.0273 0.3062 0.306
Toxoplasma gondii thioredoxin reductase 0.0048 0.0393 0.059
Trypanosoma cruzi beta tubulin, putative 0.0359 0.4088 0.6408
Toxoplasma gondii histone deacetylase HDAC1 0.0302 0.3418 0.5353
Schistosoma mansoni tubulin subunit alpha 0.0273 0.3062 0.306
Trypanosoma cruzi tubulin gamma chain 0.0205 0.2263 0.3533
Loa Loa (eye worm) tubulin gamma chain 0.0205 0.2263 0.3234
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0256 0.0402
Leishmania major hypothetical protein, conserved 0.005 0.0417 0.0629
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0417 0.0629
Brugia malayi MH2 domain containing protein 0.0603 0.6992 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0099 0.0996 0.0994

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 3 mg kg-1 Inhibition of spontaneous motor activity in mice, by administering perorally ChEMBL. 2571727
ED50 (functional) = 3 mg kg-1 Inhibition of spontaneous motor activity in mice, by administering perorally ChEMBL. 2571727
ED50 (functional) = 4.7 mg kg-1 Inhibition of amphetamine-induced hypermobility in mice following p.o. administration. ChEMBL. 2571727
ED50 (functional) = 4.7 mg kg-1 Inhibition of amphetamine-induced hypermobility in mice following p.o. administration. ChEMBL. 2571727
Inhibition (functional) = 0 % Antagonistic activity against apomorphine-induced stereotypy in rats, by administering perorally at a dose of 400 mg/kg ChEMBL. 2571727
Inhibition (functional) = 0 % Activity of the compound to evoke catalepsy in rats, by administering perorally at a dose of 150 mg/kg ChEMBL. 2571727
LD50 (ADMET) > 1000 mg kg-1 Lethal dose in mice (LD50) following i.p. dosing ChEMBL. 2571727
LD50 (ADMET) > 1000 mg kg-1 Lethal dose in mice (LD50) following i.p. dosing ChEMBL. 2571727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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