Detailed information for compound 116702

Basic information

Technical information
  • TDR Targets ID: 116702
  • Name: 4-(4-chlorophenyl)-5-[2-(4-phenylpiperazin-1- yl)ethyl]-3H-1,3-oxazol-2-one
  • MW: 383.871 | Formula: C21H22ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 4.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nc(oc1CCN1CCN(CC1)c1ccccc1)O
  • InChi: 1S/C21H22ClN3O2/c22-17-8-6-16(7-9-17)20-19(27-21(26)23-20)10-11-24-12-14-25(15-13-24)18-4-2-1-3-5-18/h1-9H,10-15H2,(H,23,26)
  • InChiKey: GHLFWWUERYGWEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-chlorophenyl)-5-[2-(4-phenylpiperazin-1-yl)ethyl]-3H-oxazol-2-one
  • 4-(4-chlorophenyl)-5-[2-(4-phenyl-1-piperazinyl)ethyl]-3H-oxazol-2-one
  • 4-(4-chlorophenyl)-5-[2-(4-phenylpiperazino)ethyl]-4-oxazolin-2-one
  • 52868-08-3
  • 4-(4-Chlorophenyl)-5-(2-(4-phenyl-1-piperazinyl)ethyl)-2(3H)-oxazolone
  • BRN 1170810
  • 2(3H)-Oxazolone, 4-(4-chlorophenyl)-5-(2-(4-phenyl-1-piperazinyl)ethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Brugia malayi beta-lactamase 0.0037 0.0256 0.0363
Loa Loa (eye worm) hypothetical protein 0.0083 0.081 0.1155
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0024 0.0109 0.0144
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1137 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0047 0.0374 0.0372
Plasmodium vivax glutathione reductase, putative 0.0048 0.0393 0.059
Plasmodium falciparum tubulin gamma chain 0.0205 0.2263 0.3533
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.0248
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0168 0.0166
Trypanosoma cruzi histone deacetylase 1, putative 0.0551 0.637 1
Schistosoma mansoni RAR-like nuclear receptor 0.0099 0.0996 0.0994
Schistosoma mansoni coup transcription factor 0.0099 0.0996 0.0994
Loa Loa (eye worm) histone deacetylase 11 0.0191 0.2095 0.2994
Trypanosoma brucei beta tubulin 0.0205 0.2263 0.3533
Loa Loa (eye worm) tubulin beta-1 chain 0.0359 0.4088 0.5846
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.3062 0.306
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Giardia lamblia Alpha-tubulin 0.0273 0.3062 0.4791
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.5474 0.5472
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0047 0.0064
Schistosoma mansoni nuclear receptor 0.0047 0.0374 0.0372
Brugia malayi Cytochrome P450 family protein 0.0053 0.0454 0.0646
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1273 0.4845
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi MH1 domain containing protein 0.0023 0.009 0.0125
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0135 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Onchocerca volvulus 0.0245 0.2737 0.6399
Toxoplasma gondii ABC1 family protein 0.0037 0.0256 0.0374
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1127 0.4282
Echinococcus granulosus CREB binding protein 0.0071 0.0662 0.066
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Schistosoma mansoni flap endonuclease-1 0.0024 0.0105 0.0102
Echinococcus multilocularis tubulin epsilon chain 0.0205 0.2263 0.2261
Plasmodium falciparum tubulin epsilon chain, putative 0.0205 0.2263 0.3533
Schistosoma mansoni tubulin subunit alpha 0.0089 0.088 0.0878
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0135 0.0184
Loa Loa (eye worm) hypothetical protein 0.005 0.0419 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0099 0.0996 0.1421
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.3062 0.4377
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1137 0.1723
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0037 0.0057
Leishmania major histone deacetylase, putative 0.0302 0.3418 0.5353
Echinococcus multilocularis tubulin subunit TubB 0.0273 0.3062 0.306
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0024 0.0109 0.0098
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus granulosus flap endonuclease 1 0.0027 0.0135 0.0133
Trypanosoma brucei alpha tubulin, putative 0.0116 0.1202 0.1863
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.2737 0.3913
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0256 0.0254
Trypanosoma cruzi alpha tubulin, putative 0.0273 0.3062 0.4791
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.0996 0.1421
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0393 0.059
Trypanosoma cruzi histone deacetylase 1, putative 0.0551 0.637 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0064 0.0409
Brugia malayi acetyltransferase, GNAT family protein 0.0292 0.329 0.4704
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0089 0.088 0.1382
Plasmodium falciparum alpha tubulin 2 0.0273 0.3062 0.4791
Toxoplasma gondii histone deacetylase HDAC5 0.0191 0.2095 0.3269
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0417 0.0629
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.1128 0.161
Brugia malayi nuclear receptor NHR-88 0.0047 0.0374 0.0532
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0099 0.0996 0.0994
Plasmodium falciparum thioredoxin reductase 0.0048 0.0393 0.059
Brugia malayi Histone deacetylase family protein 0.0302 0.3418 0.4887
Loa Loa (eye worm) hypothetical protein 0.0152 0.163 0.2329
Brugia malayi PAS domain containing protein 0.005 0.0409 0.0582
Trichomonas vaginalis tubulin gamma chain, putative 0.0205 0.2263 0.3552
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Brugia malayi hypothetical protein 0.0067 0.0619 0.0882
Toxoplasma gondii beta tubulin 0.0359 0.4088 0.6408
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.1127 0.8793
Brugia malayi Dihydrofolate reductase 0.0045 0.0351 0.0498
Loa Loa (eye worm) steroid hormone receptor 0.0099 0.0996 0.1421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0664 0.1042
Loa Loa (eye worm) tubulin gamma chain 0.0205 0.2263 0.3234
Echinococcus granulosus tubulin beta 1 chain 0.0359 0.4088 0.4087
Leishmania major histone deacetylase, putative 0.0302 0.3418 0.5353
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0256 0.0254
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.3062 0.306
Brugia malayi intermediate filament protein 0.0027 0.0146 0.0206
Trypanosoma brucei histone deacetylase 1 0.0551 0.637 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0256 0.0918
Brugia malayi Tubulin alpha chain 0.0089 0.088 0.1256
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0088 0.0085
Trypanosoma cruzi histone deacetylase, putative 0.0302 0.3418 0.5353
Loa Loa (eye worm) histone deacetylase 1 0.0551 0.637 0.9111
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Brugia malayi tubulin alpha-2 chain 0.0273 0.3062 0.4377
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0109 0.0153
Plasmodium vivax tubulin epsilon chain, putative 0.0205 0.2263 0.3533
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0047 0.0374 0.0532
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0256 0.0363
Trypanosoma brucei tubulin delta chain 0.0089 0.088 0.1357
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0855 0.1343
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0045
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0749 0.5664
Brugia malayi MH2 domain containing protein 0.0603 0.6992 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0183 0.2001 0.3141
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0045
Brugia malayi nuclear hormone receptor 0.0047 0.0374 0.0532
Echinococcus granulosus muscleblind protein 0.0152 0.163 0.1628
Mycobacterium tuberculosis Probable reductase 0.011 0.1127 0.4282
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0293 0.046
Loa Loa (eye worm) hypothetical protein 0.0166 0.1798 0.2569
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0199 0.2191 0.2189
Trichomonas vaginalis tubulin alpha chain, putative 0.0116 0.1202 0.1887
Trypanosoma brucei zeta tubulin, putative 0.0089 0.088 0.1357
Loa Loa (eye worm) hypothetical protein 0.0078 0.0749 0.1068
Loa Loa (eye worm) tubulin alpha-3 chain 0.0156 0.1679 0.2399
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0047 0.0113
Leishmania major hypothetical protein, conserved 0.0024 0.0109 0.0144
Brugia malayi photoreceptor-specific nuclear receptor 0.0099 0.0996 0.1421
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.3062 0.306
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0243
Trichomonas vaginalis tubulin, putative 0.0089 0.088 0.1382
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Leishmania major delta tubulin, putative 0.0089 0.088 0.1357
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0097 0.0708
Echinococcus granulosus thyroid hormone receptor alpha 0.0047 0.0374 0.0372
Entamoeba histolytica tubulin alpha-1 chain 0.0273 0.3062 0.4767
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus granulosus alpha tubulin 0.0273 0.3062 0.306
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1137 1
Loa Loa (eye worm) p25-alpha family protein 0.0373 0.4256 0.6085
Trypanosoma cruzi epsilon tubulin, putative 0.0205 0.2263 0.3533
Echinococcus multilocularis beta tubulin 0.0359 0.4088 0.4087
Brugia malayi hypothetical protein 0.0047 0.0374 0.0532
Schistosoma mansoni tubulin subunit alpha 0.0273 0.3062 0.306
Leishmania major histone deacetylase, putative 0.0551 0.637 1
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Plasmodium falciparum alpha tubulin 1 0.0273 0.3062 0.4791
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0308 0.0306
Mycobacterium tuberculosis Conserved protein 0.0037 0.0256 0.0918
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0398 0.0565
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.3062 0.306
Loa Loa (eye worm) tubulin beta-4 chain 0.0359 0.4088 0.5846
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.0212
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0146 0.0206
Leishmania major hypothetical protein, conserved 0.0024 0.0109 0.0144
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0047 0.0064
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.0248
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0374 0.0532
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0046
Trypanosoma cruzi zeta tubulin, putative 0.0089 0.088 0.1357
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0904 0.1291
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1137 0.4321
Loa Loa (eye worm) BEN-1 protein 0.0359 0.4088 0.5846
Brugia malayi dihydrofolate reductase family protein 0.0045 0.0351 0.0498
Giardia lamblia Gamma tubulin 0.0205 0.2263 0.3533
Trichomonas vaginalis tubulin alpha chain, putative 0.0205 0.2263 0.3552
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0047 0.0374 0.0372
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.0351 0.2971
Mycobacterium tuberculosis Cell division protein FtsZ 0.0089 0.088 0.3329
Schistosoma mansoni histone deacetylase 4 5 0.0302 0.3418 0.3417
Echinococcus multilocularis musashi 0.0027 0.0146 0.0144
Echinococcus multilocularis tubulin delta chain 0.0089 0.088 0.0878
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0064 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0099 0.0996 0.1421
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.3062 0.4791
Echinococcus multilocularis geminin 0.0856 1 1
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0064 0.0409
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Echinococcus granulosus histone acetyltransferase KAT2B 0.0282 0.3172 0.317
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0256 0.0363
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0045 0.0351 0.2372
Giardia lamblia Beta tubulin 0.0359 0.4088 0.6408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Leishmania major hypothetical protein, conserved 0.0037 0.0256 0.0374
Schistosoma mansoni nuclear hormone receptor 0.0099 0.0996 0.0994
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Brugia malayi glutathione reductase 0.0048 0.0393 0.0558
Schistosoma mansoni histone deacetylase hda2 0.0191 0.2095 0.2093
Brugia malayi phosphofructokinase 0.0111 0.1137 0.1624
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0185
Schistosoma mansoni tubulin subunit epsilon 0.0205 0.2263 0.2261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0099 0.0996 0.0994
Giardia lamblia Epsilon tubulin 0.0089 0.088 0.1357
Brugia malayi Steroid receptor seven-up type 2 0.0099 0.0996 0.1421
Schistosoma mansoni alpha tubulin 0.0273 0.3062 0.306
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0052 0.0439 0.0663
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0374 0.0532
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0769 0.0766
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0551 0.637 1
Schistosoma mansoni histone deacetylase hda2 0.0327 0.3708 0.3707
Toxoplasma gondii alpha tubulin TUBA1 0.0273 0.3062 0.4791
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0099 0.0996 0.1421
Brugia malayi ecdysteroid receptor 0.0099 0.0996 0.1421
Onchocerca volvulus 0.0099 0.0996 0.2271
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0273 0.3062 0.4806
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus multilocularis jun protein 0.0086 0.0837 0.0835
Trichomonas vaginalis esterase, putative 0.0037 0.0256 0.0402
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus multilocularis thyroid hormone receptor alpha 0.0227 0.2522 0.252
Loa Loa (eye worm) nuclear receptor NHR-67 0.0047 0.0374 0.0532
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0769 0.1096
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0227 0.2522 0.252
Trypanosoma cruzi tubulin gamma chain 0.0205 0.2263 0.3533
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0156 0.1679 0.2636
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0256 0.0254
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0416 0.0413
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0749 0.1151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0048 0.0396 0.0564
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0038 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0189 0.0187
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0419 0.0417
Loa Loa (eye worm) hypothetical protein 0.005 0.0417 0.0594
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.0769 0.1182
Onchocerca volvulus 0.0043 0.0327 0.0686
Entamoeba histolytica tubulin gamma chain 0.0205 0.2263 0.3503
Trichomonas vaginalis tubulin alpha chain, putative 0.0116 0.1202 0.1887
Brugia malayi hypothetical protein 0.0052 0.0441 0.0627
Brugia malayi Histone deacetylase family protein 0.0302 0.3418 0.4887
Schistosoma mansoni smad1 5 8 and 0.0041 0.0308 0.0306
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0256 0.0402
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0097 0.0125
Echinococcus granulosus CREB binding protein 0.011 0.1133 0.1131
Brugia malayi nuclear hormone receptor 0.0099 0.0996 0.1421
Brugia malayi nuclear hormone receptor family member odr-7 0.0047 0.0374 0.0532
Schistosoma mansoni tubulin subunit alpha 0.0273 0.3062 0.306
Brugia malayi MH2 domain containing protein 0.0041 0.0308 0.0437
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.3062 0.4377
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0292 0.329 0.3289
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0109 0.0153
Echinococcus granulosus chromobox protein 1 0.0071 0.0664 0.0662
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0664 0.1042
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1137 0.1723
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0598 0.0914
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0393 0.039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Brugia malayi MH2 domain containing protein 0.0018 0.0038 0.0051
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0329 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0439 0.0689
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.0351 0.4552
Plasmodium vivax histone deacetylase 2, putative 0.0302 0.3418 0.5353
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0417 0.0629
Onchocerca volvulus 0.0037 0.0256 0.0517
Onchocerca volvulus 0.0029 0.0168 0.0308
Trypanosoma cruzi histone deacetylase, putative 0.0302 0.3418 0.5353
Brugia malayi nuclear receptor NHR-67 0.0047 0.0374 0.0532
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Brugia malayi MH1 domain containing protein 0.0041 0.0308 0.0437
Schistosoma mansoni hypothetical protein 0.007 0.0647 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.088 0.1382
Onchocerca volvulus 0.0109 0.1122 0.257
Loa Loa (eye worm) hypothetical protein 0.0551 0.637 0.9111
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.0351 0.0348
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0308 0.0437
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0183 0.2001 0.2859
Schistosoma mansoni tubulin subunit delta 0.0089 0.088 0.0878
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) tubulin beta chain 0.0089 0.088 0.1256
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0749 0.115
Schistosoma mansoni retinoic acid receptor RXR 0.0199 0.2191 0.2189
Plasmodium vivax tubulin gamma chain, putative 0.0205 0.2263 0.3533
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0256 0.0918
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0168 0.0236
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0189 0.0269
Schistosoma mansoni smad 0.0041 0.0308 0.0306
Brugia malayi Flap endonuclease-1 0.0027 0.0135 0.019
Plasmodium vivax delta tubulin, putative 0.0089 0.088 0.1357
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0175 0.0275
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0047 0.0374 0.0532
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0256 0.2125
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 0.2154
Loa Loa (eye worm) hypothetical protein 0.0152 0.163 0.2329
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0256 0.2125
Onchocerca volvulus 0.005 0.0419 0.0904
Echinococcus multilocularis tubulin alpha 0.0205 0.2263 0.2261
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0135 0.0133
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0769 0.0766
Echinococcus multilocularis Smad4 0.0041 0.0308 0.0306
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.2608 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0047 0.0046
Echinococcus multilocularis histone deacetylase 8 0.0191 0.2095 0.2093
Giardia lamblia Beta tubulin 0.0359 0.4088 0.6408
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus granulosus BRCA1 associated protein 0.0024 0.0109 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0293 0.046
Echinococcus granulosus thymidylate synthase 0.0109 0.1122 0.112
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.3062 0.306
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0904 0.0902
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0749 0.1151
Loa Loa (eye worm) histone deacetylase 7A 0.0302 0.3418 0.4887
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0175 0.0248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.2685 0.3838
Trichomonas vaginalis tubulin beta chain, putative 0.0359 0.4088 0.6418
Trypanosoma cruzi beta tubulin, putative 0.0359 0.4088 0.6408
Loa Loa (eye worm) tubulin alpha 2 0.0183 0.2001 0.2859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0904 0.0902
Echinococcus granulosus chromobox protein 1 0.0071 0.0664 0.0662
Schistosoma mansoni steroid hormone receptor ad4bp 0.0099 0.0996 0.0994
Echinococcus multilocularis histone deacetylase 6 0.0302 0.3418 0.3417
Brugia malayi tubulin alpha chain - mouse 0.0273 0.3062 0.4377
Echinococcus granulosus histone deacetylase 3 0.0551 0.637 0.637
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0256 0.0363
Toxoplasma gondii histone deacetylase HDAC1 0.0302 0.3418 0.5353
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0749 0.111
Loa Loa (eye worm) nuclear factor I 0.0023 0.009 0.0125
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0024 0.0109 0.0153
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0308 0.0306
Schistosoma mansoni tubulin subunit alpha 0.0273 0.3062 0.306
Echinococcus multilocularis smad 0.0041 0.0308 0.0306
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0109 0.0144
Brugia malayi hypothetical protein 0.0166 0.1798 0.2569
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0996 0.1421
Echinococcus multilocularis BRCA1 associated protein 0.0024 0.0109 0.0107
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Brugia malayi hypothetical protein 0.0052 0.0441 0.0627
Echinococcus granulosus histone deacetylase 1 0.0551 0.637 0.637
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0664 0.0947
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.3062 0.4806
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0256 0.0918
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2699 0.4236
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0064 0.0177
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0441 0.0439
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0038 0.0051
Schistosoma mansoni dihydrofolate reductase 0.0045 0.0351 0.0348
Toxoplasma gondii exonuclease III APE 0.0019 0.0047 0.0046
Schistosoma mansoni chromobox protein 0.0071 0.0664 0.0662
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Trichomonas vaginalis brca1-associated protein, putative 0.0024 0.0109 0.0172
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0189 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0189 0.0187
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Toxoplasma gondii beta-1 tubulin, putative 0.0359 0.4088 0.6408
Loa Loa (eye worm) tubulin alpha 2 0.0067 0.0619 0.0882
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Loa Loa (eye worm) Smad1 0.0041 0.0308 0.0437
Chlamydia trachomatis endonuclease IV 0.0078 0.0749 1
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0024 0.0109 0.0169
Onchocerca volvulus 0.0031 0.0191 0.0362
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.5474 0.5472
Echinococcus multilocularis beta tubulin 0.0359 0.4088 0.4087
Echinococcus multilocularis tumor protein p63 0.0344 0.3916 0.3914
Onchocerca volvulus Histone deacetylase 10 homolog 0.0191 0.2095 0.4876
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0099 0.0996 0.0994
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0256 0.1589
Echinococcus multilocularis ecdysone induced protein 78C 0.0099 0.0996 0.0994
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0047 0.0262
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Echinococcus granulosus smad 0.0041 0.0308 0.0306
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0267
Trypanosoma brucei zeta tubulin 0.0089 0.088 0.1357
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0088
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Tubulin gamma chain 0.0205 0.2263 0.3234
Loa Loa (eye worm) tubulin beta-2A chain 0.0359 0.4088 0.5846
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Brugia malayi TAZ zinc finger family protein 0.011 0.1133 0.1617
Brugia malayi thymidylate synthase 0.0109 0.1122 0.1602
Schistosoma mansoni CREB-binding protein 2 0.011 0.1133 0.1131
Loa Loa (eye worm) hypothetical protein 0.0183 0.2001 0.2859
Schistosoma mansoni lamin 0.0027 0.0146 0.0144
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0135 0.0184
Toxoplasma gondii histone deacetylase HDAC2 0.0551 0.637 1
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.088 0.1382
Onchocerca volvulus Bile acid receptor homolog 0.0099 0.0996 0.2271
Onchocerca volvulus 0.0037 0.0262 0.0532
Trichomonas vaginalis tubulin gamma chain, putative 0.0205 0.2263 0.3552
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0551 0.637 1
Echinococcus granulosus histone deacetylase 8 0.0191 0.2095 0.2093
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0097 0.0136
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.3062 0.306
Loa Loa (eye worm) beta-lactamase 0.0037 0.0256 0.0363
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0182 0.1981 0.1979
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Loa Loa (eye worm) histone deacetylase 0.0302 0.3418 0.4887
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1137 0.8877
Onchocerca volvulus 0.0067 0.0619 0.1377
Echinococcus multilocularis histone deacetylase 6 0.0302 0.3418 0.3417
Echinococcus granulosus histone deacetylase 6 0.0302 0.3418 0.3417
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0769 0.1182
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0099 0.0996 0.0994
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0024 0.0109 0.0153
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1127 0.4282
Onchocerca volvulus Protein ultraspiracle homolog 0.0099 0.0996 0.2271
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0417 0.0629
Loa Loa (eye worm) hypothetical protein 0.0156 0.1679 0.2399
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Entamoeba histolytica hypothetical protein 0.0182 0.1981 0.3058
Trypanosoma brucei histone deacetylase 3 0.0302 0.3418 0.5353
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0024 0.0109 0.0107
Mycobacterium leprae cell division protein FtsZ 0.0089 0.088 0.6752
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0109 0.0144
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0256 0.2125
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.0248
Brugia malayi MH1 domain containing protein 0.0041 0.0308 0.0437
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0047 0.0262
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Brugia malayi CXXC zinc finger family protein 0.0029 0.0168 0.0236
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Schistosoma mansoni tubulin subunit gamma 0.0205 0.2263 0.2261
Schistosoma mansoni hypothetical protein 0.0023 0.0088 0.0085
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0417 0.0629
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0769 0.1182
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.3062 0.306
Echinococcus multilocularis thymidylate synthase 0.0109 0.1122 0.112
Schistosoma mansoni Smad4 0.0041 0.0308 0.0306
Schistosoma mansoni histone deacetylase 0.0551 0.637 0.637
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0256 0.0402
Mycobacterium ulcerans beta-lactamase 0.0037 0.0256 0.2125
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0197
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.3062 0.306
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0097 0.0136
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0099 0.0996 0.1421
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0329 0.0516
Schistosoma mansoni hypothetical protein 0.0856 1 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0393 0.0558
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Leishmania major epsilon tubulin, putative 0.0205 0.2263 0.3533
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0099 0.0996 0.2271
Echinococcus granulosus histone deacetylase 7 0.0302 0.3418 0.3417
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0308 0.0306
Brugia malayi bZIP transcription factor family protein 0.0086 0.0837 0.1195
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0047 0.0374 0.0372
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.0996 0.1421
Brugia malayi Tubulin beta chain 0.0116 0.1202 0.1716
Brugia malayi BRCA1-associated protein 2 containing protein 0.0024 0.0109 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0099 0.0996 0.1421
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.3062 0.306
Echinococcus granulosus tubulin delta chain 0.0089 0.088 0.0878
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0038 0.0051
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0417 0.0629
Leishmania major cytochrome p450-like protein 0.0023 0.0097 0.0125
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0182 0.1981 0.1979
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0398 0.0565
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0099 0.0996 0.0994
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0018 0.0022
Echinococcus granulosus beta tubulin 0.0359 0.4088 0.4087
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0359 0.4088 0.4087
Brugia malayi hypothetical protein 0.005 0.0417 0.0594
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1273 0.4845
Echinococcus multilocularis peroxisome assembly protein 26 0.0273 0.3062 0.306
Brugia malayi beta-lactamase family protein 0.0037 0.0256 0.0363
Brugia malayi histone deacetylase 3 (HD3) 0.0551 0.637 0.9111
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0374 0.0798
Schistosoma mansoni thyroid hormone receptor 0.0227 0.2522 0.252
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1346 0.1344
Trypanosoma cruzi tubulin delta chain 0.0089 0.088 0.1357
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.3062 0.306
Echinococcus multilocularis tubulin gamma 1 chain 0.0205 0.2263 0.2261
Echinococcus granulosus CREB binding protein 0.0017 0.0021 0.0019
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1137 0.1135
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0024 0.0109 0.0098
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0769 0.1182
Entamoeba histolytica histone deacetylase, putative 0.0551 0.637 1
Brugia malayi Tubulin alpha-2 chain 0.0273 0.3062 0.4377
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.235 0.3359
Leishmania major hypothetical protein, conserved 0.005 0.0417 0.0629
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Schistosoma mansoni smad1 5 8 and 0.0041 0.0308 0.0306
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1137 0.1723
Echinococcus granulosus Smad4 0.0041 0.0308 0.0306
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1137 0.1624
Plasmodium falciparum histone deacetylase 1 0.0551 0.637 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0146 0.0206
Brugia malayi Cytochrome P450 family protein 0.0023 0.0097 0.0136
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi hypoxia-induced factor 1 0.0153 0.1645 0.235
Loa Loa (eye worm) histone deacetylase 3 0.0551 0.637 0.9111
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0855 0.0853
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0551 0.637 1
Brugia malayi Thioredoxin reductase 0.0048 0.0393 0.0558
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0256 0.0918
Echinococcus granulosus single minded 2 0.0037 0.0256 0.0254
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0135 0.0212
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0024 0.0109 0.0098
Brugia malayi isocitrate dehydrogenase 0.008 0.0769 0.1096
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1137 0.1762
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0089 0.088 0.1357
Trichomonas vaginalis tubulin alpha chain, putative 0.0116 0.1202 0.1887
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Trypanosoma cruzi histone deacetylase, putative 0.0191 0.2095 0.3269
Leishmania major zeta tubulin, putative 0.0089 0.088 0.1357
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0018 0.0028
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0052 0.0441 0.0439
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0308 0.0306
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0016
Giardia lamblia Alpha-tubulin 0.0273 0.3062 0.4791
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0329 0.069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0904 0.0902
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0109 0.1122 0.112
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1273 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0256 0.2125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0099 0.0996 0.1421
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0393 0.059
Loa Loa (eye worm) nuclear hormone receptor 0.0047 0.0374 0.0532
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0147 0.1569 0.1567
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 0.2154
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0256 0.0254
Plasmodium vivax SET domain protein, putative 0.0031 0.0189 0.0269
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1346 0.1344
Giardia lamblia Delta tubulin 0.0089 0.088 0.1357
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Loa Loa (eye worm) tubulin alpha-2 chain 0.0273 0.3062 0.4377
Echinococcus multilocularis muscleblind protein 1 0.0152 0.163 0.1628
Loa Loa (eye worm) transcription factor SMAD2 0.0603 0.6992 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0269
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0024 0.0109 0.0107
Trypanosoma brucei histone deacetylase 2 0.0191 0.2095 0.3269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0099 0.0996 0.1421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Echinococcus granulosus histone deacetylase 6 0.0302 0.3418 0.3417
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0256 0.0374
Toxoplasma gondii beta-tubulin, putative 0.0359 0.4088 0.6408
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0097 0.0125
Loa Loa (eye worm) thymidylate synthase 0.0109 0.1122 0.1602
Brugia malayi tailless protein 0.0047 0.0374 0.0532
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Echinococcus granulosus ecdysone induced protein 78C 0.0099 0.0996 0.0994
Schistosoma mansoni hypothetical protein 0.0856 1 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0016
Onchocerca volvulus 0.0037 0.0256 0.0517
Loa Loa (eye worm) BEN-1 protein 0.0359 0.4088 0.5846
Brugia malayi Smad1 0.0041 0.0308 0.0437
Brugia malayi Tubulin beta chain 0.0089 0.088 0.1256
Brugia malayi Histone deacetylase 1 0.0551 0.637 0.9111
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Onchocerca volvulus 0.0116 0.1202 0.2759
Loa Loa (eye worm) hypothetical protein 0.0033 0.0215 0.0304
Schistosoma mansoni alpha tubulin 0.0273 0.3062 0.306
Schistosoma mansoni Smad4 0.0018 0.0038 0.0035
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.5474 0.5472
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0099 0.0996 0.0994
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0256 0.0374
Echinococcus granulosus intermediate filament protein 0.0027 0.0146 0.0144
Loa Loa (eye worm) tubulin alpha 2 0.0183 0.2001 0.2859
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0046
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0109 0.1122 0.8752
Brugia malayi orphan nuclear receptor NR2E1 0.0047 0.0374 0.0532
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Brugia malayi MH2 domain containing protein 0.0041 0.0308 0.0437
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Mycobacterium ulcerans thymidylate synthase 0.0109 0.1122 0.9865
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0135 0.0139
Echinococcus multilocularis histone deacetylase 7 0.0302 0.3418 0.3417
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0109 0.1122 0.4263
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Loa Loa (eye worm) MH2 domain-containing protein 0.0603 0.6992 1
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0109 0.0107
Echinococcus granulosus jun protein 0.0086 0.0837 0.0835
Schistosoma mansoni single-minded 0.005 0.0409 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Trypanosoma brucei epsilon tubulin 0.0205 0.2263 0.3533
Schistosoma mansoni chromobox protein 0.0071 0.0664 0.0662
Loa Loa (eye worm) hypothetical protein 0.0273 0.3062 0.4377
Brugia malayi Cell division protein ftsZ 0.0089 0.088 0.1256
Schistosoma mansoni tubulin subunit beta 0.0089 0.088 0.0878
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0016
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0769 0.1182
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0099 0.0996 0.1421
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0175 0.0248
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0089 0.088 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0374 0.0372
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Schistosoma mansoni Smad4 0.0018 0.0038 0.0035
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1137 0.1762
Brugia malayi steroid hormone receptor 0.0099 0.0996 0.1421
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.3062 0.4806
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0175 0.0248
Plasmodium falciparum flap endonuclease 1 0.0027 0.0135 0.0184
Brugia malayi beta-lactamase family protein 0.0037 0.0256 0.0363
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0769 0.2898
Echinococcus multilocularis hypothetical protein 0.0273 0.3062 0.306
Onchocerca volvulus TPPP family protein homolog 0.0373 0.4256 1
Trypanosoma cruzi histone deacetylase, putative 0.0191 0.2095 0.3269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0904 0.0902
Plasmodium falciparum glutathione reductase 0.0048 0.0393 0.059
Loa Loa (eye worm) hypothetical protein 0.0191 0.2095 0.2994
Entamoeba histolytica tubulin family protein 0.0359 0.4088 0.6391
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0327 0.0325
Echinococcus granulosus transcription factor eb 0.011 0.1128 0.1126
Brugia malayi nuclear hormone receptor family member nhr-6 0.0047 0.0374 0.0532
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0256 0.0374
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1137 0.1624
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0052 0.0441 0.0627
Trichomonas vaginalis histone deacetylase, putative 0.0551 0.637 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.0248
Mycobacterium leprae Probable lipase LipE 0.0037 0.0256 0.1589
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0089 0.088 0.1357
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0037 0.0057
Trypanosoma cruzi epsilon tubulin, putative 0.0205 0.2263 0.3533
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0109 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0996 0.1421
Leishmania major gamma-tubulin 0.0205 0.2263 0.3533
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0454 0.0646
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0099 0.0996 0.1421
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0125
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.3062 0.306
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0047 0.0045
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0215 0.0304
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Onchocerca volvulus 0.0242 0.2699 0.6308
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0099 0.0996 0.0994
Loa Loa (eye worm) hypothetical protein 0.0111 0.1143 0.1632
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.0996 0.0994
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0749 0.1068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0099 0.0996 0.1421
Echinococcus granulosus peroxisome assembly protein 26 0.0273 0.3062 0.306
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0109 0.0153
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1127 0.4282
Trichomonas vaginalis tubulin epsilon chain, putative 0.0359 0.4088 0.6418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.0996 0.1421
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0189 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0256 0.0402
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0904 0.0902
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0099 0.0996 0.0994
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0769 0.1182
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0393 0.039
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0855 0.1318
Brugia malayi nuclear receptor NHR-88 0.0099 0.0996 0.1421
Echinococcus multilocularis chromobox protein 1 0.0071 0.0664 0.0662
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0047 0.0374 0.0372
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0256 0.0918
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0135 0.0184
Echinococcus multilocularis lamin dm0 0.0027 0.0146 0.0144
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus granulosus nuclear receptor nhr 48 0.0047 0.0374 0.0372
Schistosoma mansoni transcription factor LCR-F1 0.0182 0.1981 0.1979
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0256 0.0374
Brugia malayi histone deacetylase 11 0.0191 0.2095 0.2994
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0097 0.0125
Schistosoma mansoni zinc finger protein 0.0047 0.0374 0.0372
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1273 0.4845
Echinococcus granulosus tubulin gamma 1 chain 0.0205 0.2263 0.2261
Echinococcus multilocularis histone deacetylase 0.0302 0.3418 0.3417
Toxoplasma gondii alpha-tubulin I, putative 0.0273 0.3062 0.4791
Mycobacterium ulcerans hypothetical protein 0.0037 0.0256 0.2125
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0047 0.0046
Schistosoma mansoni intermediate filament proteins 0.0027 0.0146 0.0144
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Echinococcus granulosus tumor protein p63 0.0344 0.3916 0.3914
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Trypanosoma cruzi zeta tubulin, putative 0.0089 0.088 0.1357
Brugia malayi histone deacetylase 1 (HD1) 0.0551 0.637 0.9111
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0769 0.1182
Plasmodium falciparum tubulin beta chain 0.0359 0.4088 0.6408
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0749 0.2821
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0441 0.0627
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0292 0.329 0.3289
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0047 0.0045
Schistosoma mansoni histone deacetylase 0.0551 0.637 0.637
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0256 0.0402
Entamoeba histolytica tubulin family protein 0.0359 0.4088 0.6391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0904 0.0902
Schistosoma mansoni histone deacetylase 4 5 0.0302 0.3418 0.3417
Brugia malayi Isocitrate dehydrogenase 0.008 0.0769 0.1096
Loa Loa (eye worm) CBP-B 0.0079 0.0757 0.108
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0099 0.0996 0.1421
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0374 0.0372
Brugia malayi Heterochromatin protein 1 0.0071 0.0664 0.0947
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Echinococcus granulosus tubulin subunit TubB 0.0273 0.3062 0.306
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.3062 0.306
Brugia malayi Tubulin alpha-2 chain 0.0273 0.3062 0.4377
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0047 0.034
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0175 0.0202
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.1122 0.1601
Brugia malayi Pax transcription factor protein 2 0.0245 0.2737 0.3913
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0024 0.0109 0.0144
Echinococcus multilocularis histone deacetylase 3 0.0551 0.637 0.637
Brugia malayi Muscleblind-like protein 0.0152 0.163 0.2329
Brugia malayi MH1 domain containing protein 0.0023 0.009 0.0125
Trichomonas vaginalis tubulin gamma chain, putative 0.0089 0.088 0.1382
Brugia malayi hypothetical protein 0.0047 0.0374 0.0532
Echinococcus granulosus cpg binding protein 0.0031 0.0187 0.0185
Plasmodium falciparum histone deacetylase 2 0.0302 0.3418 0.5353
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.3062 0.4791
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Echinococcus multilocularis chromobox protein 1 0.0071 0.0664 0.0662
Trypanosoma brucei epsilon tubulin 0.0205 0.2263 0.3533
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Echinococcus granulosus tubulin epsilon chain 0.0205 0.2263 0.2261
Toxoplasma gondii endonuclease IV APN 0.0078 0.0749 0.115
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.0351 0.1284
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0175 0.0248
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0256 0.0918
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Plasmodium falciparum tubulin delta chain, putative 0.0089 0.088 0.1357
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0024 0.0109 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus multilocularis histone deacetylase 1 0.0551 0.637 0.637
Mycobacterium ulcerans epimerase 0.0021 0.0064 0.0409
Echinococcus multilocularis tubulin subunit beta 0.0359 0.4088 0.4087
Brugia malayi conserved hypotetical protein 0.0047 0.0374 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0099 0.0996 0.1421
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1127 0.4282
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0099 0.0996 0.0994
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0374 0.0372
Brugia malayi Tubulin beta-1 chain 0.0359 0.4088 0.5846
Echinococcus granulosus lamin 0.0027 0.0146 0.0144
Loa Loa (eye worm) beta-tubulin 0.0359 0.4088 0.5846
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0024 0.0109 0.0107
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Schistosoma mansoni smad1 5 8 and 0.0041 0.0308 0.0306
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0086 0.0837 0.0835
Plasmodium vivax tubulin beta chain, putative 0.0359 0.4088 0.6408
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Trichomonas vaginalis tubulin beta chain, putative 0.0116 0.1202 0.1887
Schistosoma mansoni histone deacetylase 1 2 3 0.0191 0.2095 0.2093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0099 0.0996 0.0994
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0293 0.0605
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Trypanosoma brucei beta tubulin 0.0359 0.4088 0.6408
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1127 0.4282
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1137 0.1785
Loa Loa (eye worm) hypothetical protein 0.0109 0.1122 0.1601
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.011 0.1133 0.1131
Trichomonas vaginalis BRCA1-associated protein, putative 0.0024 0.0109 0.0172
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0393 0.0558
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Echinococcus granulosus tubulin beta 4A class IVa 0.0359 0.4088 0.4087
Schistosoma mansoni hypothetical protein 0.0053 0.0446 0.0444
Echinococcus multilocularis tubulin beta 1 chain 0.0359 0.4088 0.4087
Trichomonas vaginalis tubulin, putative 0.0116 0.1202 0.1887
Plasmodium vivax histone deacetylase, putative 0.0302 0.3418 0.5353
Trichomonas vaginalis tubulin gamma chain, putative 0.0359 0.4088 0.6418
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Echinococcus multilocularis muscleblind protein 0.0152 0.163 0.1628
Echinococcus multilocularis CREB binding protein 0.0078 0.0747 0.0744
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0024 0.0109 0.0144
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0769 0.1182
Brugia malayi Tubulin alpha chain 0.0273 0.3062 0.4377
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0109 0.0144
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0308 0.0306
Echinococcus granulosus beta tubulin 0.0359 0.4088 0.4087
Schistosoma mansoni lamin 0.0027 0.0146 0.0144
Trichomonas vaginalis tubulin epsilon chain, putative 0.0359 0.4088 0.6418
Plasmodium falciparum histone deacetylase, putative 0.0302 0.3418 0.5353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0099 0.0996 0.1421
Plasmodium vivax histone deacetylase, putative 0.0191 0.2095 0.3269
Giardia lamblia Beta tubulin 0.0359 0.4088 0.6408
Brugia malayi chromobox protein homolog 3 0.004 0.0293 0.0416
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0769 0.1182
Echinococcus multilocularis CREB binding protein 0.0017 0.0021 0.0019
Brugia malayi Pre-SET motif family protein 0.0213 0.235 0.3359
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0099 0.0996 0.0994
Brugia malayi hypothetical protein 0.0182 0.1981 0.2831
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0099 0.0996 0.1421
Trypanosoma brucei histone deacetylase 4 0.0302 0.3418 0.5353
Echinococcus granulosus tubulin subunit beta 0.0359 0.4088 0.4087
Echinococcus multilocularis transcription factor eb 0.011 0.1128 0.1126
Trichomonas vaginalis tubulin epsilon chain, putative 0.0089 0.088 0.1382
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0088 0.0085
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0086 0.0837 0.0835
Brugia malayi nuclear receptor RXR 0.0047 0.0374 0.0532
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0441 0.0627
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1137 0.1135
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0374 0.0372
Echinococcus granulosus histone deacetylase 0.0302 0.3418 0.3417
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0571 0.0569
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0109 0.0144
Onchocerca volvulus 0.0047 0.0374 0.0798
Brugia malayi nuclear receptor RXR 0.0052 0.0441 0.0627
Mycobacterium ulcerans cell division protein FtsZ 0.0089 0.088 0.7704
Echinococcus multilocularis CREB binding protein 0.0017 0.0021 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0256 0.0918
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1137 0.1135
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0417 0.0629
Loa Loa (eye worm) hypothetical protein 0.0136 0.1433 0.2046
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0769 0.0766
Brugia malayi alpha-tubulin 0.0273 0.3062 0.4377
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1137 0.1135
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0038 0.0035
Mycobacterium tuberculosis Conserved protein 0.0037 0.0256 0.0918
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1137 0.1762
Echinococcus multilocularis CREB binding protein 0.0017 0.0021 0.0019
Loa Loa (eye worm) DR-78 0.0047 0.0374 0.0532
Schistosoma mansoni hypothetical protein 0.0128 0.1346 0.1344
Trypanosoma brucei trypanothione reductase 0.0048 0.0393 0.059
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0064 0.0061
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1137 0.1624
Loa Loa (eye worm) alpha-tubulin 0.0273 0.3062 0.4377
Plasmodium vivax histone deacetylase 1, putative 0.0551 0.637 1
Loa Loa (eye worm) acetyltransferase 0.0292 0.329 0.4704
Treponema pallidum cell division protein FtsZ 0.0089 0.088 0.7704
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0109 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.0996 0.0994
Toxoplasma gondii histone deacetylase HDAC3 0.0551 0.637 1
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0374 0.0372
Loa Loa (eye worm) tubulin beta chain 0.0359 0.4088 0.5846
Trichomonas vaginalis tubulin, putative 0.0116 0.1202 0.1887
Trichomonas vaginalis tubulin, putative 0.0359 0.4088 0.6418
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0046
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0109 0.0107
Giardia lamblia Histone deacetylase 0.0551 0.637 1
Leishmania major trypanothione reductase 0.0048 0.0393 0.059
Echinococcus granulosus tubulin alpha 0.0205 0.2263 0.2261
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.3062 0.306
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.0996 0.1421
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0099 0.0996 0.0994
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0826 0.965 0.965
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0154 0.1653 0.2574
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1421
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0374 0.0798
Echinococcus granulosus tubulin alpha chain 0.0273 0.3062 0.306
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0398 0.0565
Schistosoma mansoni cpg binding protein 0.0029 0.0168 0.0165
Echinococcus granulosus histone deacetylase 6 0.0327 0.3708 0.3707
Schistosoma mansoni nuclear receptor 0.0047 0.0374 0.0372
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0052 0.0441 0.0439
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0189 0.0187
Echinococcus granulosus lamin dm0 0.0027 0.0146 0.0144
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0024 0.0109 0.0144
Mycobacterium ulcerans endonuclease IV 0.0078 0.0749 0.6528
Schistosoma mansoni alpha tubulin 0.0273 0.3062 0.306
Loa Loa (eye worm) hypothetical protein 0.0047 0.0374 0.0532
Trypanosoma cruzi tubulin delta chain 0.0089 0.088 0.1357
Brugia malayi hypothetical protein 0.0032 0.0205 0.0291
Brugia malayi Cytochrome P450 family protein 0.0023 0.0097 0.0136
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Onchocerca volvulus 0.0027 0.0146 0.0257
Trichomonas vaginalis tubulin alpha chain, putative 0.0359 0.4088 0.6418
Brugia malayi follicle stimulating hormone receptor 0.0241 0.2685 0.3838
Echinococcus granulosus Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0275
Echinococcus granulosus dihydrofolate reductase 0.0045 0.0351 0.0348
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0855 0.1343
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0256 0.0254
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Echinococcus granulosus neuropeptide s receptor 0.0475 0.5474 0.5472
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0109 0.0107
Trypanosoma cruzi histone deacetylase, putative 0.0302 0.3418 0.5353
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.3062 0.4806
Echinococcus multilocularis Tubulin beta 2C chain 0.0359 0.4088 0.4087
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0154 0.1653 0.2574
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0109 0.0153
Schistosoma mansoni nuclear receptor nhr-48 0.0047 0.0374 0.0372
Loa Loa (eye worm) hypothetical protein 0.0049 0.0398 0.0565
Trypanosoma brucei histone deacetylase, putative 0.0302 0.3418 0.5353
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0308 0.0437
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0293 0.0416
Brugia malayi ecdysone receptor 0.0047 0.0374 0.0532
Trypanosoma brucei tubulin gamma chain 0.0205 0.2263 0.3533
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0047 0.0046
Schistosoma mansoni tubulin subunit beta 0.0359 0.4088 0.4087
Echinococcus multilocularis cpg binding protein 0.0031 0.0187 0.0185
Echinococcus granulosus CREB binding protein 0.0017 0.0021 0.0019
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0097 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0417 0.0629
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0038 0.0035
Leishmania major beta tubulin 0.0359 0.4088 0.6408
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0038 0.0035
Onchocerca volvulus 0.0027 0.0146 0.0257
Toxoplasma gondii thioredoxin reductase 0.0048 0.0393 0.059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.0996 0.1421
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Trypanosoma brucei alpha tubulin 0.0273 0.3062 0.4791
Trypanosoma brucei epsilon tubulin 0.0205 0.2263 0.3533
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0256 0.0402
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0109 0.0144
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0109 0.0107
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.1645 0.235
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0175 0.1406
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0052 0.0441 0.0439
Mycobacterium tuberculosis Hypothetical protein 0.0052 0.0439 0.1626
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0904 0.0902
Brugia malayi beta-tubulin, identical 0.0359 0.4088 0.5846
Brugia malayi Pre-SET motif family protein 0.0031 0.0189 0.0267
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0855 0.1318
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0205 0.2263 0.3533
Echinococcus multilocularis lamin 0.0027 0.0146 0.0144
Echinococcus multilocularis histone deacetylase 6 0.0327 0.3708 0.3707
Brugia malayi 6-phosphofructokinase 0.0111 0.1137 0.1624
Echinococcus granulosus FTZ F1 alpha 0.0099 0.0996 0.0994
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0109 0.0144
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0749 0.115
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0047 0.0374 0.0372
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Loa Loa (eye worm) alpha-tubulin 0.0273 0.3062 0.4377
Schistosoma mansoni smad 0.0018 0.0038 0.0035
Brugia malayi p25-alpha family protein 0.0373 0.4256 0.6085
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.0351 0.0498
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0109 0.0153
Toxoplasma gondii histone deacetylase HDAC4 0.0191 0.2095 0.3269
Schistosoma mansoni jun-related protein 0.007 0.0647 0.0645
Entamoeba histolytica tubulin alpha chain, putative 0.0273 0.3062 0.4767
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0024 0.0109 0.0107
Leishmania major alpha tubulin 0.0273 0.3062 0.4791
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0904 0.1291
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0189 0.0187
Brugia malayi 6-phosphofructokinase 0.0111 0.1137 0.1624
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0627
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0099 0.0996 0.0994
Schistosoma mansoni hypothetical protein 0.0182 0.1981 0.1979
Onchocerca volvulus 0.0037 0.0256 0.0517
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0256 0.0918
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0135 0.019
Onchocerca volvulus 0.0047 0.0374 0.0798
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0135 0.0184
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.3062 0.306
Echinococcus multilocularis tubulin alpha chain 0.0273 0.3062 0.306
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0135 0.0184
Brugia malayi hypothetical protein 0.0052 0.0439 0.0625
Echinococcus multilocularis FTZ F1 alpha 0.0099 0.0996 0.0994
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0116 0.1202 0.1887
Giardia lamblia Hypothetical protein 0.0024 0.0109 0.0144
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0109 0.0107
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0855 0.1318
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0109 0.0144
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0393 0.1446
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0769 0.0766
Leishmania major histone deacetylase, putative 0.0551 0.637 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 3 mg kg-1 Inhibition of spontaneous motor activity in mice, by administering perorally ChEMBL. 2571727
ED50 (functional) = 3 mg kg-1 Inhibition of spontaneous motor activity in mice, by administering perorally ChEMBL. 2571727
ED50 (functional) = 4.7 mg kg-1 Inhibition of amphetamine-induced hypermobility in mice following p.o. administration. ChEMBL. 2571727
ED50 (functional) = 4.7 mg kg-1 Inhibition of amphetamine-induced hypermobility in mice following p.o. administration. ChEMBL. 2571727
Inhibition (functional) = 0 % Antagonistic activity against apomorphine-induced stereotypy in rats, by administering perorally at a dose of 400 mg/kg ChEMBL. 2571727
Inhibition (functional) = 0 % Activity of the compound to evoke catalepsy in rats, by administering perorally at a dose of 150 mg/kg ChEMBL. 2571727
LD50 (ADMET) > 1000 mg kg-1 Lethal dose in mice (LD50) following i.p. dosing ChEMBL. 2571727
LD50 (ADMET) > 1000 mg kg-1 Lethal dose in mice (LD50) following i.p. dosing ChEMBL. 2571727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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