Detailed information for compound 1171102

Basic information

Technical information
  • TDR Targets ID: 1171102
  • Name: (4-bromophenyl)methylsulfanylmethanimidamide hydrobromide
  • MW: 326.051 | Formula: C8H10Br2N2S
  • H donors: 1 H acceptors: 0 LogP: 3.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)SCc1ccc(cc1)Br.Br
  • InChi: 1S/C8H9BrN2S.BrH/c9-7-3-1-6(2-4-7)5-12-8(10)11;/h1-4H,5H2,(H3,10,11);1H
  • InChiKey: PHMCIGUUXGYEBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-bromophenyl)methylsulfanylformamidine hydrobromide
  • [(4-bromophenyl)methylthio]formamidine hydrobromide
  • [(4-bromobenzyl)thio]formamidine hydrobromide
  • STK099425
  • NSC403785

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens indoleamine 2,3-dioxygenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00463 indoleamine 2,3-dioxygenase, putative Get druggable targets OG5_130288 All targets in OG5_130288
Brugia malayi indoleamine 2,3-dioxygenase Get druggable targets OG5_130288 All targets in OG5_130288
Schistosoma japonicum IPR000898,Indoleamine 2,3-dioxygenase,domain-containing Get druggable targets OG5_130288 All targets in OG5_130288
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130288 All targets in OG5_130288
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130288 All targets in OG5_130288
Candida albicans similar to indoleamine 2,3-dioxygenases Get druggable targets OG5_130288 All targets in OG5_130288
Loa Loa (eye worm) indoleamine 2,3-dioxygenase Get druggable targets OG5_130288 All targets in OG5_130288
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 Get druggable targets OG5_130288 All targets in OG5_130288
Echinococcus granulosus indoleamine 23 dioxygenase 2 Get druggable targets OG5_130288 All targets in OG5_130288
Candida albicans similar to indoleamine 2,3-dioxygenases Get druggable targets OG5_130288 All targets in OG5_130288
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0026 0.0171 0.0236
Schistosoma mansoni ap endonuclease 0.004 0.0329 0.0348
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0079 0.0763 0.2297
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0255 0.0766
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0171 0.0409
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0088 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3122 0.7451
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0083 0.0806 0.2428
Echinococcus granulosus heat shock protein 90 0.031 0.3313 0.3313
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0623 0.0659
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0088 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0125 0.0298
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1382 0.1905
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0079 0.0763 0.182
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0088 0.0211
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.001 0.0002 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0102 0.1008 0.1008
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0088 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0102 0.1008 0.139
Loa Loa (eye worm) hypothetical protein 0.0102 0.1008 0.139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0806 0.1235
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.2123 0.5068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0164 0.039
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0079 0.0763 0.132
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0912 0.0912
Echinococcus multilocularis cpg binding protein 0.0064 0.0597 0.0597
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.001 0.0002 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0623 0.086
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0083 0.0806 0.0806
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0088 0.0121
Brugia malayi RNA binding protein 0.0067 0.0623 0.086
Mycobacterium tuberculosis Possible two component sensor kinase 0.0079 0.0763 0.132
Schistosoma mansoni DNA topoisomerase II 0.0079 0.0763 0.0806
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0002 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0077 0.013
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.001 0.0002 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0329 0.0785
Loa Loa (eye worm) hypothetical protein 0.0079 0.0763 0.1051
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0088 0.0206
Trichomonas vaginalis DNA topoisomerase II, putative 0.0079 0.0763 0.182
Mycobacterium tuberculosis Conserved protein 0.0083 0.0806 0.1395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Brugia malayi TAR-binding protein 0.0067 0.0623 0.086
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0088 0.0206
Leishmania major hypothetical protein, conserved 0.0079 0.0763 0.1816
Schistosoma mansoni hypothetical protein 0.0102 0.1008 0.1065
Loa Loa (eye worm) beta-lactamase 0.0083 0.0806 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0171 0.0409
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0088 0.021
Brugia malayi CXXC zinc finger family protein 0.0061 0.0558 0.077
Trypanosoma brucei DNA topoisomerase ii 0.0079 0.0763 0.1816
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0088 0.0206
Loa Loa (eye worm) aldehyde dehydrogenase 0.001 0.0002 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0321 0.3432 0.4732
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0389 0.419 1
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0171 0.0404
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0079 0.0763 0.3789
Toxoplasma gondii aldehyde dehydrogenase 0.0191 0.1992 0.4753
Mycobacterium tuberculosis Probable esterase LipL 0.0083 0.0806 0.1395
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.2123 0.5068
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.001 0.0002 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3122 0.7451
Entamoeba histolytica hypothetical protein 0.0025 0.0164 0.039
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0255 0.044
Plasmodium vivax DNA gyrase subunit B, putative 0.0079 0.0763 0.1123
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0079 0.0763 0.2297
Mycobacterium tuberculosis Conserved protein 0.0079 0.0763 0.132
Mycobacterium ulcerans putative regultory protein 0.0079 0.0763 0.2297
Trichomonas vaginalis heat shock protein, putative 0.031 0.3313 0.7908
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0077 0.0226
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0013 0.0026
Leishmania major developmentally regulated phosphoprotein-like protein 0.0079 0.0763 0.1816
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0079 0.0763 0.2297
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0077 0.0226
Brugia malayi Hsp90 protein 0.016 0.1649 0.2274
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0079 0.0763 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Schistosoma mansoni endoplasmin 0.0389 0.419 0.4428
Trypanosoma cruzi heat shock protein 90, putative 0.0389 0.419 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0079 0.0763 0.182
Toxoplasma gondii heat shock protein 75, putative 0.016 0.1649 0.3934
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0171 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0079 0.0763 0.3789
Mycobacterium leprae conserved hypothetical protein 0.0083 0.0806 0.2428
Schistosoma mansoni ap endonuclease 0.004 0.0329 0.0348
Echinococcus granulosus heat shock protein 0.0389 0.419 0.419
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0079 0.0763 0.132
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.001 0.0002 0.0005
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.016 0.1649 0.8208
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0321 0.3432 0.4732
Chlamydia trachomatis DNA gyrase subunit B 0.0079 0.0763 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0077 0.013
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1382 0.1905
Trichomonas vaginalis sensor histidine kinase, putative 0.0079 0.0763 0.182
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0079 0.0763 0.1816
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Entamoeba histolytica heat shock protein 90, putative 0.0389 0.419 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0002 0.0002
Leishmania major heat shock protein, putative 0.016 0.1649 0.3934
Trypanosoma cruzi DNA topoisomerase II, putative 0.0079 0.0763 0.182
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.001 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0531 0.5749 0.6076
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2644 0.2644
Loa Loa (eye worm) hypothetical protein 0.0083 0.0806 0.1111
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0077 0.0226
Brugia malayi Aldehyde dehydrogenase protein 4 0.001 0.0002 0.0003
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.016 0.1649 0.1649
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.001 0.0002 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Leishmania major hypothetical protein, conserved 0.0083 0.0806 0.192
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0079 0.0763 0.182
Schistosoma mansoni cpg binding protein 0.0061 0.0558 0.059
Brugia malayi MH2 domain containing protein 0.0135 0.1382 0.1905
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0912 0.1257
Loa Loa (eye worm) hypothetical protein 0.0079 0.0763 0.1051
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0299 0.0709
Brugia malayi Cytochrome P450 family protein 0.0054 0.0488 0.0673
Trypanosoma brucei heat shock protein 90, putative 0.0389 0.419 1
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.001 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Mycobacterium leprae Probable two-component sensor kinase 0.0079 0.0763 0.2297
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0053 0.0053
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0164 0.0173
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.7326 0.7326
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.001 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0623 0.0659
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0191 0.1992 0.4753
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0449 0.0619
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0088 0.021
Schistosoma mansoni hypothetical protein 0.0051 0.0449 0.0474
Mycobacterium ulcerans lipase LipD 0.0083 0.0806 0.2428
Mycobacterium ulcerans DNA gyrase subunit B 0.0079 0.0763 0.2297
Brugia malayi Inositol-1 0.0037 0.0299 0.0412
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0077 0.013
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0088 0.0206
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0013 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trichomonas vaginalis receptor histidine kinase, putative 0.0079 0.0763 0.182
Plasmodium vivax heat shock protein, putative 0.016 0.1649 0.3421
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.001 0.0002 0.0002
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0077 0.013
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0077 0.013
Trypanosoma cruzi heat shock protein, putative 0.016 0.1649 0.3937
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0623 0.0659
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0088 0.0206
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0667 0.7253 0.7253
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Mycobacterium ulcerans hypothetical protein 0.0083 0.0806 0.2428
Giardia lamblia Grp94/Hsp90 0.031 0.3313 0.7907
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0299 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0623 0.086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0013 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0038 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Leishmania major cytochrome p450-like protein 0.0017 0.0077 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0053 0.0053
Echinococcus multilocularis heat shock protein 90 0.031 0.3313 0.3313
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0088 0.0206
Trichomonas vaginalis heat shock protein, putative 0.031 0.3313 0.7908
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0164 0.0386
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.001 0.0002 0.0002
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0079 0.0763 0.2297
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0329 0.0329
Onchocerca volvulus 0.0083 0.0806 0.4005
Brugia malayi Probable DNA topoisomerase II 0.0079 0.0763 0.1051
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0806 0.1923
Schistosoma mansoni heat shock protein 0.0389 0.419 0.4428
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0079 0.0763 0.132
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0079 0.0763 0.182
Echinococcus multilocularis heat shock protein 0.0389 0.419 0.419
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0806 0.1111
Echinococcus multilocularis neuropeptide s receptor 0.0915 1 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0079 0.0763 0.2297
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0083 0.0806 0.1395
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Brugia malayi heat shock protein 90 0.0389 0.419 0.5777
Toxoplasma gondii exonuclease III APE 0.004 0.0329 0.0781
Loa Loa (eye worm) hypothetical protein 0.0219 0.231 0.3185
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0293 0.3122 0.4304
Toxoplasma gondii Hsp90 domain-containing protein 0.016 0.1649 0.3934
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0077 0.013
Loa Loa (eye worm) TOPoisomerase family member 0.0079 0.0763 0.1051
Mycobacterium leprae putative cytochrome p450 0.0017 0.0077 0.0226
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0088 0.0206
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0191 0.1992 0.3455
Echinococcus granulosus betaine aldehyde dehydrogenase 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0077 0.013
Trypanosoma cruzi heat shock protein 85, putative 0.0389 0.419 1
Schistosoma mansoni hypothetical protein 0.0102 0.1008 0.1065
Trypanosoma brucei Heat shock protein 83, putative 0.0389 0.419 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0079 0.0763 0.182
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0077 0.013
Echinococcus granulosus beta LACTamase domain containing family member 0.0083 0.0806 0.0806
Loa Loa (eye worm) hypothetical protein 0.0083 0.0806 0.1111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.031 0.3313 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Loa Loa (eye worm) hypothetical protein 0.0083 0.0806 0.1111
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0079 0.0763 0.2297
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0038 0.0092
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.8879 0.8879
Schistosoma mansoni survival motor neuron protein 0.0051 0.0449 0.0474
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0079 0.0763 0.182
Loa Loa (eye worm) latrophilin receptor protein 2 0.0102 0.1008 0.139
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0077 0.0226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0038 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0806 0.1923
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0088 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0077 0.013
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0293 0.3122 0.4304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0912 0.0963
Schistosoma mansoni inositol monophosphatase 0.0037 0.0299 0.0316
Brugia malayi Cytochrome P450 family protein 0.0026 0.0171 0.0236
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0083 0.0806 0.1395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0912 0.0912
Loa Loa (eye worm) RNA binding protein 0.0067 0.0623 0.086
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.001 0.0002 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0329 0.0781
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0299 0.0299
Echinococcus multilocularis geminin 0.0531 0.5749 0.5749
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0077 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0094 0.0094
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0077 0.0226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0912 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0077 0.0226
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0077 0.0226
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0079 0.0763 0.1816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0164 0.0226
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0002
Trypanosoma brucei heat shock protein 90, putative 0.0389 0.419 1
Plasmodium falciparum heat shock protein 90, putative 0.016 0.1649 0.3421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0079 0.0763 0.1123
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.031 0.3313 0.7907
Trichomonas vaginalis receptor histidine kinase, putative 0.0079 0.0763 0.182
Brugia malayi beta-lactamase family protein 0.0083 0.0806 0.1111
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0623 0.0659
Trypanosoma brucei developmentally regulated phosphoprotein 0.0079 0.0763 0.1816
Brugia malayi beta-lactamase family protein 0.0083 0.0806 0.1111
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0088 0.021
Echinococcus granulosus GPCR family 2 0.0102 0.1008 0.1008
Echinococcus granulosus geminin 0.0531 0.5749 0.5749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0329 0.0987
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0077 0.013
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0002 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0488 0.0673
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0077 0.0226
Mycobacterium tuberculosis Probable lipase LipE 0.0083 0.0806 0.1395
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0079 0.0763 0.1816
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2644 0.2644
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0079 0.0763 0.1051
Schistosoma mansoni cpg binding protein 0.0064 0.0597 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Echinococcus multilocularis endoplasmin 0.031 0.3313 0.3313
Echinococcus multilocularis heat shock protein 90 0.0389 0.419 0.419
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0079 0.0763 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.1992 0.6011
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0079 0.0763 0.2297
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0077 0.013
Onchocerca volvulus 0.0083 0.0806 0.4005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0102 0.1008 0.1008
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.0002 0.0002
Schistosoma mansoni endoplasmin 0.0389 0.419 0.4428
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0083 0.0806 0.1395
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0171 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.1992 0.6011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0053 0.0053
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0164 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0002 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0806 0.1923
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0077 0.013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0191 0.1992 0.1992
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0079 0.0763 0.132
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3122 0.7451
Plasmodium vivax heat shock protein 90, putative 0.016 0.1649 0.3421
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0077 0.0183
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0079 0.0763 0.132
Leishmania major DNA topoisomerase ii 0.0079 0.0763 0.1816
Loa Loa (eye worm) hypothetical protein 0.0083 0.0806 0.1111
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.001 0.0002 0.0003
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.001 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0077 0.0226
Schistosoma mansoni hypothetical protein 0.0102 0.1008 0.1065
Schistosoma mansoni heat shock protein 0.016 0.1649 0.1743
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Schistosoma mansoni heat shock protein 0.0389 0.419 0.4428
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0077 0.0226
Mycobacterium ulcerans two component sensor kinase MprB 0.0079 0.0763 0.2297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1312 0.1387
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0077 0.0226
Schistosoma mansoni inositol monophosphatase 0.0037 0.0299 0.0316
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0102 0.1008 0.1008
Loa Loa (eye worm) cytochrome P450 0.0017 0.0077 0.0106
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0164 0.039
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0329 0.0785
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0088 0.021
Loa Loa (eye worm) inositol-1 0.0037 0.0299 0.0412
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.001 0.0002 0.0002
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0079 0.0763 0.132
Leishmania major cytochrome p450-like protein 0.0026 0.0171 0.0404
Giardia lamblia GTOR 0.0018 0.0088 0.0206
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0077 0.0226
Entamoeba histolytica DNA topoisomerase II, putative 0.0079 0.0763 0.182
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.031 0.3313 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0867 0.9462 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0038 0.0092
Leishmania major cytochrome p450-like protein 0.0017 0.0077 0.0179
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0667 0.7253 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.016 0.1649 0.3937
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0077 0.0179
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0079 0.0763 0.2297
Mycobacterium tuberculosis Probable hydrolase 0.0083 0.0806 0.1395
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0038 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0806 0.0852
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.116 0.2765
Plasmodium falciparum DNA gyrase subunit B 0.0079 0.0763 0.1123
Plasmodium falciparum DNA topoisomerase 2 0.0079 0.0763 0.1123
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.1992 0.2106
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0079 0.0763 0.0763
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0079 0.0763 0.2297
Schistosoma mansoni hypothetical protein 0.0219 0.231 0.2441
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0053 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3122 0.7451
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0002 0.0005
Giardia lamblia Pms1-like protein 0.0079 0.0763 0.1816
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0102 0.1008 0.1008
Treponema pallidum heat shock protein 90 0.031 0.3313 1
Entamoeba histolytica heat shock protein 90, putative 0.0389 0.419 1
Onchocerca volvulus 0.0051 0.0449 0.2225
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0667 0.7253 0.7253
Onchocerca volvulus 0.0061 0.0558 0.2772
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0079 0.0763 0.182
Echinococcus granulosus endoplasmin 0.031 0.3313 0.3313
Plasmodium vivax endoplasmin, putative 0.0389 0.419 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0079 0.0763 0.2297
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Mycobacterium tuberculosis Probable lipase LipD 0.0083 0.0806 0.1395
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0329 0.0781
Loa Loa (eye worm) hypothetical protein 0.0079 0.0763 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Mycobacterium ulcerans heat shock protein 90 0.031 0.3313 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0912 0.0912
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0088 0.021
Giardia lamblia Heat shock protein HSP 90-alpha 0.031 0.3313 0.7907
Loa Loa (eye worm) heat shock protein 75 0.016 0.1649 0.2274
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0079 0.0763 0.2297
Onchocerca volvulus Glucosylceramidase homolog 0.0192 0.2009 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0079 0.0763 0.1816
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.001 0.0002 0.0005
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0079 0.0763 0.132
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0329 0.0785
Trypanosoma cruzi heat shock protein 85, putative 0.0389 0.419 1
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0002 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0088 0.0206
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0088 0.021
Trichomonas vaginalis esterase, putative 0.0083 0.0806 0.1923
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0077 0.0226
Echinococcus granulosus tar DNA binding protein 0.0067 0.0623 0.0623
Plasmodium falciparum heat shock protein 90, putative 0.016 0.1649 0.3421
Loa Loa (eye worm) hypothetical protein 0.0083 0.0806 0.1111
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.031 0.3313 0.5748
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0091 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0806 0.0852
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0102 0.1008 0.139
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0299 0.0713
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0053 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0077 0.013
Onchocerca volvulus 0.0083 0.0806 0.4005
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0077 0.013
Brugia malayi indoleamine 2,3-dioxygenase 0.0667 0.7253 1
Toxoplasma gondii heat shock protein 90, putative 0.0389 0.419 1
Plasmodium falciparum heat shock protein 90 0.0389 0.419 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0079 0.0763 0.2297
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0079 0.0763 0.1051
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0164 0.0164
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0077 0.0179
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.016 0.1649 0.1649
Brugia malayi cytochrome P450 0.0017 0.0077 0.0106
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0329 0.0453
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0077 0.013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0299 0.0713
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3122 0.7451
Mycobacterium ulcerans two component regulator - sensor kinase 0.0079 0.0763 0.2297
Plasmodium falciparum endoplasmin, putative 0.0239 0.2526 0.5691
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Plasmodium vivax DNA topoisomerase II, putative 0.0079 0.0763 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Giardia lamblia Heat shock protein HSP 90-alpha 0.0389 0.419 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0912 0.0963
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0002 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0329 0.0329
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0558 0.077
Mycobacterium leprae Probable two component sensor kinase MprB 0.0079 0.0763 0.2297
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0077 0.0226
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0088 0.0121
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.001 0.0002 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.1992 0.2106
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.001 0.0002 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0867 0.9462 0.9462
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0077 0.0226
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0806 0.1923
Echinococcus multilocularis dnaJ subfamily B 0.0867 0.9462 0.9462
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0088 0.021
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0077 0.013
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0088 0.0207
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0088 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0219 0.231 0.3185
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0623 0.0659
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0329 0.0785
Brugia malayi Endoplasmin precursor 0.0389 0.419 0.5777
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.001 0.0002 0.0002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0088 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Trichomonas vaginalis heat shock protein, putative 0.0239 0.2526 0.6029
Trichomonas vaginalis heat shock protein, putative 0.031 0.3313 0.7908
Trypanosoma cruzi heat shock protein 90, putative 0.031 0.3313 0.7908
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0623 0.086
Loa Loa (eye worm) heat shock protein 90 0.0389 0.419 0.5777
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0018
Toxoplasma gondii heat shock protein HSP90 0.0389 0.419 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0088 0.0121
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0077 0.0226
Mycobacterium leprae Probable lipase LipE 0.0083 0.0806 0.2428
Echinococcus multilocularis 0.0017 0.0077 0.0077
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0299 0.0713
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0299 0.0299
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0171 0.0511
Trichomonas vaginalis heat shock protein, putative 0.0389 0.419 1
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.001 0.0002 0.0005
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0077 0.0226
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.001 0.0002 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0038 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0077 0.0226
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0038 0.0092
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0077 0.0077
Schistosoma mansoni pyruvate dehydrogenase 0.0079 0.0763 0.0806
Schistosoma mansoni hypothetical protein 0.0017 0.0077 0.0081
Schistosoma mansoni cytochrome P450 0.0017 0.0077 0.0081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0083 0.0806 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0806 0.1923
Brugia malayi aldehyde dehydrogenase 0.001 0.0002 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0299 0.0896
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.001 0.0002 0.0005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0299 0.0896
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0299 0.0713
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0079 0.0763 0.182
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0079 0.0763 0.0763
Echinococcus granulosus cpg binding protein 0.0064 0.0597 0.0597
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0329 0.0781
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0077 0.0183
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0079 0.0763 0.132
Brugia malayi hypothetical protein 0.025 0.2644 0.3646
Schistosoma mansoni hypothetical protein 0.0531 0.5749 0.6076
Loa Loa (eye worm) endoplasmin 0.0389 0.419 0.5777
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0079 0.0763 0.132
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0077 0.0226
Schistosoma mansoni hypothetical protein 0.0667 0.7253 0.7665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3122 0.7451
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0329 0.0987
Schistosoma mansoni cpg binding protein 0.0064 0.0597 0.0631
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0079 0.0763 0.1816
Toxoplasma gondii DNA topoisomerase 2, putative 0.0079 0.0763 0.1816
Mycobacterium tuberculosis Probable two component sensor kinase 0.0079 0.0763 0.132
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0079 0.0763 0.182
Echinococcus multilocularis neuropeptide receptor A26 0.0915 1 1
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0329 0.0453
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0077 0.0226
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0088 0.0088
Echinococcus granulosus heat shock protein 90 0.0389 0.419 0.419
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0094 0.013
Schistosoma mansoni hypothetical protein 0.0667 0.7253 0.7665
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0806 0.1923
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0912 0.1257
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0329 0.0987
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0083 0.0806 0.1111
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0079 0.0763 0.2297
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0077 0.0226
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0088 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0532 0.5762 1
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.7326 0.7742
Trypanosoma cruzi heat shock protein 85, putative 0.031 0.3313 0.7908
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.031 0.3313 0.3313
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.001 0.0002 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0321 0.3432 0.4732
Echinococcus multilocularis GPCR, family 2 0.0102 0.1008 0.1008
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.001 0.0002 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.4795
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0079 0.0763 0.1816
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0806 0.192
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0077 0.013
Plasmodium vivax heat shock protein 86, putative 0.0389 0.419 1
Toxoplasma gondii ABC1 family protein 0.0083 0.0806 0.192
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0763 0.1123
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0079 0.0763 0.3789
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0191 0.1992 0.1992
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0299 0.0713
Loa Loa (eye worm) hypothetical protein 0.025 0.2644 0.3646
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0623 0.0623
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0079 0.0763 0.0763
Schistosoma mansoni hypothetical protein 0.0102 0.1008 0.1065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0329 0.0785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0912 0.0963
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0077 0.0179
Trypanosoma cruzi heat shock protein 90, putative 0.023 0.2426 0.5791
Trypanosoma brucei heat shock protein, putative 0.0389 0.419 1
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0079 0.0763 0.182
Trypanosoma brucei heat shock protein 84, putative 0.016 0.1649 0.3934
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0079 0.0763 0.0763
Mycobacterium ulcerans beta-lactamase 0.0083 0.0806 0.2428
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.1992 0.6011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0088 0.021
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0002 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.0083 0.0806 0.2428
Leishmania major mitochondrial DNA topoisomerase II 0.0079 0.0763 0.1816
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0079 0.0763 0.132
Brugia malayi beta-lactamase 0.0083 0.0806 0.1111
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0077 0.013
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0806 0.1923
Echinococcus granulosus microtubule associated protein 2 0.0673 0.7326 0.7326
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0038 0.0092
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0079 0.0763 0.132
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0079 0.0763 0.2297
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0077 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0013 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.0915 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0171 0.0236
Mycobacterium tuberculosis Conserved protein 0.0083 0.0806 0.1395
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0172
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0077 0.0183
Brugia malayi Calcitonin receptor-like protein seb-1 0.0321 0.3432 0.4732
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0329 0.0567
Trypanosoma cruzi heat shock protein 85, putative 0.0389 0.419 1
Trichomonas vaginalis helicase, putative 0.0014 0.0038 0.0092
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0079 0.0763 0.2297
Trichomonas vaginalis endoplasmin, putative 0.0239 0.2526 0.6029
Chlamydia trachomatis DNA gyrase subunit B 0.0079 0.0763 0.5
Brugia malayi Cytochrome P450 family protein 0.0017 0.0077 0.0106
Leishmania major heat shock protein 83-1 0.0389 0.419 1
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.0002 0.0002
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0299 0.0713
Mycobacterium tuberculosis Conserved protein 0.0083 0.0806 0.1395
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0299 0.0709
Trichomonas vaginalis heat shock protein, putative 0.016 0.1649 0.3937
Brugia malayi kinase, mitochondrial precursor 0.0079 0.0763 0.1051

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.8 uM Inhibition of indoleamine-2,3-dioxygenase in human A431 cells assessed as inhibition of IFN-gamma-stimulated kynurenine production ChEMBL. 20688518
IC50 (binding) = 1.3 uM Inhibition of indoleamine-2,3-dioxygenase ChEMBL. 20688518

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.