Detailed information for compound 1175044

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1848.84 | Formula: C92H159ClN22O15
  • H donors: 21 H acceptors: 15 LogP: 5.82 Rotable bonds: 78
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CC(C)C)C(C)C)CCCCN)CC(C)C)C(C)C)C)[C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](CCCC[N+](C)(C)C)N)CCCCN)CC(C)C)CCCCN.[Cl-]
  • InChi: 1S/C92H158N22O15.ClH/c1-17-59(12)78(90(127)100-53-75(115)101-60(13)80(117)111-76(57(8)9)92(129)110-72(49-56(6)7)86(123)105-68(40-25-30-44-95)84(121)112-77(58(10)11)91(128)106-70(79(98)116)47-54(2)3)113-85(122)69(41-26-31-45-96)102-82(119)66(38-23-28-42-93)103-88(125)73(50-61-33-19-18-20-34-61)109-87(124)71(48-55(4)5)108-83(120)67(39-24-29-43-94)104-89(126)74(51-62-52-99-65-37-22-21-35-63(62)65)107-81(118)64(97)36-27-32-46-114(14,15)16;/h18-22,33-35,37,52,54-60,64,66-74,76-78,99H,17,23-32,36,38-51,53,93-97H2,1-16H3,(H15-,98,100,101,102,103,104,105,106,107,108,109,110,111,112,113,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129);1H/t59-,60-,64-,66-,67-,68-,69-,70-,71-,72-,73-,74-,76-,77-,78-;/m0./s1
  • InChiKey: WYMJYNLUSOOYTA-LYLHQTILSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.066
Mycobacterium leprae conserved hypothetical protein 0.0293 0.0797 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0118 0.0269 0.0364
Loa Loa (eye worm) TAR-binding protein 0.0342 0.0943 0.1277
Brugia malayi Cathepsin L-like precursor 0.0087 0.0175 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0342 0.0943 0.1277
Schistosoma mansoni hypothetical protein 0.0144 0.0348 0.0471
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0013 0.0018
Giardia lamblia Kinesin-5 0.0266 0.0716 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0184 0.0244
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Brugia malayi Cathepsin L-like precursor 0.0087 0.0175 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0005 0.0007
Schistosoma mansoni zinc finger protein 0.0046 0.0053 0.0072
Onchocerca volvulus 0.0144 0.0348 0.1599
Schistosoma mansoni hypothetical protein 0.0214 0.0557 0.0754
Schistosoma mansoni hypothetical protein 0.0108 0.0238 0.0322
Leishmania major cathepsin L-like protease 0.0331 0.091 0.4884
Echinococcus granulosus cysteine protease 0.0045 0.0048 0.006
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0022 0.0084
Loa Loa (eye worm) hypothetical protein 0.0147 0.0358 0.0484
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0006 0.0008
Mycobacterium leprae Probable lipase LipE 0.0293 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.012
Echinococcus multilocularis cathepsin L cysteine protease 0.0087 0.0175 0.0171
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0037 0.0025 0.0033
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0045 0.0048 0.0065
Echinococcus granulosus snurportin 1 0.032 0.0878 0.1183
Schistosoma mansoni coup transcription factor 0.003 0.0005 0.0007
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0404 0.0542
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0018 0.0167
Toxoplasma gondii kinesin motor domain-containing protein 0.0266 0.0716 0.869
Toxoplasma gondii LsmAD domain-containing protein 0.0082 0.0161 0.1924
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0143 0.0345 0.1862
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0022 0.023
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.002 0.0027
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0675 0.1949 0.2637
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Schistosoma mansoni cathepsin F (C01 family) 0.0087 0.0175 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0175 0.0237
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0119 0.0191
Echinococcus multilocularis beta LACTamase domain containing family member 0.0293 0.0797 0.0794
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0089 0.0393
Schistosoma mansoni hypothetical protein 0.1061 0.3111 0.421
Loa Loa (eye worm) hypothetical protein 0.0293 0.0797 0.1079
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0071 0.0091
Loa Loa (eye worm) fli-1 protein 0.0215 0.056 0.0758
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 0.1356
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0063 0.0102 0.0138
Mycobacterium tuberculosis Probable esterase LipL 0.0293 0.0797 0.1414
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0005 0.0002
Brugia malayi hypothetical protein 0.0053 0.0074 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Schistosoma mansoni ets-related 0.0215 0.056 0.0758
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0392 0.0531
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0256 0.0342
Entamoeba histolytica kinesin, putative 0.0266 0.0716 1
Echinococcus multilocularis Smad4 0.0035 0.002 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0246 0.0655 0.0651
Schistosoma mansoni cpg binding protein 0.0118 0.0269 0.0364
Onchocerca volvulus 0.0094 0.0197 0.0896
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0048 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0012 0.0011
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0256 0.1368
Brugia malayi latrophilin 2 splice variant baaae 0.0462 0.1305 0.1766
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0012 0.0008
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0071 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0029 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0282 0.1293
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0143 0.0709
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0005 0.0002
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0143 0.014
Onchocerca volvulus 0.0087 0.0175 0.0793
Echinococcus granulosus kinesin family 1 0.2049 0.609 0.8241
Brugia malayi cathepsin L-like precursor 0.0058 0.0089 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0256 0.1176
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0245 0.1326
Mycobacterium tuberculosis Conserved protein 0.0293 0.0797 0.1414
Brugia malayi Cathepsin L-like precursor 0.0087 0.0175 0.0237
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0103 0.0225 0.0305
Schistosoma mansoni jumonji domain containing protein 0.0212 0.0553 0.0748
Echinococcus granulosus cpg binding protein 0.013 0.0307 0.041
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0109 0.0243 0.0239
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0031 0.015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0013 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0092 0.1082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0154 0.0208
Schistosoma mansoni gabp alpha 0.0071 0.0127 0.0171
Schistosoma mansoni nuclear hormone receptor 0.003 0.0005 0.0007
Onchocerca volvulus 0.0087 0.0175 0.0793
Schistosoma mansoni alpha glucosidase 0.0036 0.0022 0.003
Schistosoma mansoni kinesin eg-5 0.0266 0.0716 0.0969
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0013 0.0018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0143 0.0345 0.1862
Echinococcus multilocularis cathepsin L 0.0045 0.0048 0.0044
Trypanosoma brucei ISWI complex protein 0.0046 0.0053 0.0269
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0013 0.0009
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0194 0.0885
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0006 0.0028
Plasmodium vivax vivapain-3 0.0045 0.0048 0.0606
Plasmodium vivax unspecified product 0.0045 0.0048 0.0606
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0238 0.0234
Brugia malayi jmjC domain containing protein 0.0035 0.0018 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0256 0.1176
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0194 0.2322
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0194 0.2322
Onchocerca volvulus 0.0087 0.0175 0.0793
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0048 0.0058 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0084
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0005 0.0002
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.0816 0.1104
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0002
Echinococcus multilocularis musashi 0.0226 0.0596 0.0592
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.0816 0.1104
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.002 0.0016
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0256 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Leishmania major hypothetical protein, conserved 0.0293 0.0797 0.4269
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0006 0.0008
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0031 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Plasmodium falciparum kinesin-5 0.0266 0.0716 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0143 0.0756
Brugia malayi Cathepsin L-like precursor 0.0087 0.0175 0.0237
Loa Loa (eye worm) jmjC domain-containing protein 0.0142 0.0341 0.0462
Brugia malayi Cathepsin L-like precursor 0.0058 0.0089 0.012
Trypanosoma cruzi major cysteine proteinase, putative 0.026 0.0697 0.3767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0058 0.0251
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0031 0.0028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0675 0.1949 0.2637
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0013 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0006 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0652 0.1877 0.2541
Echinococcus granulosus cathepsin l cysteine peptidase 0.0087 0.0175 0.0232
Trypanosoma brucei glucosidase, putative 0.0036 0.0022 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0707 0.3279
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0707 0.3279
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0018 0.0014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0031 0.0043
Echinococcus granulosus cathepsin l1 0.0087 0.0175 0.0232
Schistosoma mansoni lamin 0.0226 0.0596 0.0806
Loa Loa (eye worm) hypothetical protein 0.0147 0.0358 0.0485
Onchocerca volvulus 0.0293 0.0797 0.3698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0127 0.0171
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0114 0.0257 0.1325
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0246 0.0655 0.0881
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0092 0.0089
Trypanosoma cruzi target of rapamycin kinase 3 0.0114 0.0257 0.1387
Plasmodium falciparum phd finger protein, putative 0.0059 0.0092 0.1245
Loa Loa (eye worm) hypothetical protein 0.0215 0.0561 0.0759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0256 0.3526
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0462 0.2137
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0092 0.0125
Brugia malayi Bromodomain containing protein 0.0123 0.0285 0.0386
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0045 0.0048 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0005 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0005 0.0002
Loa Loa (eye worm) Smad1 0.0035 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0081 0.0159 0.0215
Brugia malayi PHD-finger family protein 0.0059 0.0092 0.0125
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Loa Loa (eye worm) histone methyltransferase 0.004 0.0034 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Schistosoma mansoni cpg binding protein 0.013 0.0307 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Brugia malayi hypothetical protein 0.0147 0.0358 0.0485
Schistosoma mansoni intermediate filament proteins 0.0226 0.0596 0.0806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Echinococcus granulosus lamin 0.0226 0.0596 0.0802
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Brugia malayi 6-phosphofructokinase 0.0114 0.0256 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0707 0.3279
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.002 0.0022
Onchocerca volvulus 0.0087 0.0175 0.0793
Loa Loa (eye worm) hypothetical protein 0.0087 0.0175 0.0237
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0256 0.3526
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Loa Loa (eye worm) ctsf protein 0.0087 0.0175 0.0237
Onchocerca volvulus 0.0087 0.0175 0.0793
Brugia malayi Cathepsin L-like precursor 0.0058 0.0089 0.012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0031 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Brugia malayi TAR-binding protein 0.0342 0.0943 0.1277
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0643 0.1851 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0186 0.1004
Loa Loa (eye worm) beta-lactamase 0.0293 0.0797 0.1079
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0018 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0045 0.0048 0.0065
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0468
Leishmania major cathepsin L-like protease 0.0087 0.0175 0.0882
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0013 0.0114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0293 0.0797 0.1079
Brugia malayi beta-lactamase family protein 0.0293 0.0797 0.1079
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.054 0.292
Loa Loa (eye worm) bromodomain containing protein 0.0061 0.0097 0.0131
Loa Loa (eye worm) transcription factor SMAD2 0.0519 0.1478 0.2
Toxoplasma gondii ABC1 family protein 0.0293 0.0797 0.9687
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0087 0.0175 0.2407
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0194 0.0885
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0022 0.0121
Schistosoma mansoni jumonji/arid domain-containing protein 0.0142 0.0341 0.0462
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0005 0.0002
Schistosoma mansoni alpha-glucosidase 0.014 0.0336 0.0455
Loa Loa (eye worm) hypothetical protein 0.0197 0.0506 0.0685
Echinococcus multilocularis lysine specific demethylase 5A 0.0129 0.0304 0.03
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0304 0.083 0.4475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0168 0.0766
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0127 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0005 0.0007
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0434 0.2002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0342 0.0943 0.1277
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0175 0.0237
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0256 0.0347
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0143 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Trypanosoma brucei PAB1-binding protein , putative 0.0082 0.0161 0.0854
Onchocerca volvulus 0.0226 0.0596 0.2757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0246 0.0655 0.0886
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.0816 0.0812
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0018 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0013 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0048 0.0594
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0031 0.0389
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0194 0.2433
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0186 0.1004
Brugia malayi follicle stimulating hormone receptor 0.0232 0.0611 0.0827
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0246 0.0655 0.0886
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0256 0.1176
Plasmodium falciparum cysteine proteinase falcipain 1 0.0045 0.0048 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0005 0.0007
Brugia malayi Cathepsin L-like cysteine proteinase 0.0058 0.0089 0.012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0106 0.0234 0.281
Loa Loa (eye worm) hypothetical protein 0.0105 0.023 0.0312
Onchocerca volvulus 0.0741 0.2148 1
Schistosoma mansoni hypothetical protein 0.0081 0.0159 0.0215
Brugia malayi steroid hormone receptor 0.003 0.0005 0.0007
Brugia malayi Cathepsin L-like precursor 0.0087 0.0175 0.0237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0005 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0246 0.0655 0.0886
Brugia malayi Inositol-1 0.0076 0.0143 0.0194
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0006 0.0008
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0018 0.0192
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0168 0.0222
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.0506 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0171 0.0778
Brugia malayi Importin beta-1 subunit 0.003 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Leishmania major cathepsin L-like protease 0.0087 0.0175 0.0882
Brugia malayi Smad1 0.0035 0.002 0.0027
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0018 0.0019
Leishmania major cysteine peptidase A (CPA) 0.0087 0.0175 0.0882
Onchocerca volvulus 0.0058 0.0089 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Trypanosoma cruzi cruzipain precursor, putative 0.0331 0.091 0.492
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.0797 0.3701
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0302 0.0823 0.146
Brugia malayi MH1 domain containing protein 0.0035 0.002 0.0027
Echinococcus multilocularis GPCR, family 2 0.0214 0.0557 0.0554
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0256 0.2552
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0195 0.0502 0.0674
Echinococcus granulosus methyl CpG binding domain protein 2 0.0052 0.007 0.0089
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.0611 0.0827
Echinococcus multilocularis cysteine protease 0.0087 0.0175 0.0171
Entamoeba histolytica hypothetical protein 0.0108 0.0238 0.3262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Trichomonas vaginalis set domain proteins, putative 0.0741 0.2148 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0005 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0254 0.0678 0.0917
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 0.5902
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0089 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0256 0.1176
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0168 0.0227
Echinococcus granulosus lamin dm0 0.0226 0.0596 0.0802
Schistosoma mansoni hypothetical protein 0.0046 0.0053 0.0072
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0256 1
Trypanosoma cruzi ISWI complex protein 0.0046 0.0053 0.0289
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0005 0.0007
Mycobacterium tuberculosis Conserved protein 0.0293 0.0797 0.1414
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0345 0.1587
Echinococcus granulosus mixed lineage leukemia protein mll 0.0033 0.0012 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0005 0.0007
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0256 0.0347
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0302 0.0823 0.082
Trypanosoma cruzi cysteine proteinase, putative 0.0045 0.0048 0.0261
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0143 0.9153
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.1204 0.12
Echinococcus granulosus FTZ F1 alpha 0.003 0.0005 0.0002
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0018 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0048 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0005 0.0007
Schistosoma mansoni survival motor neuron protein 0.0144 0.0348 0.0471
Echinococcus multilocularis cysteine protease 0.0087 0.0175 0.0171
Schistosoma mansoni cpg binding protein 0.013 0.0307 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0293 0.0797 0.4309
Plasmodium vivax ataxin-2 like protein, putative 0.0082 0.0161 0.2025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0214 0.0557 0.0754
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0707 0.3279
Loa Loa (eye worm) hypothetical protein 0.0059 0.0092 0.0125
Echinococcus multilocularis tar DNA binding protein 0.0342 0.0943 0.094
Trypanosoma brucei DNA polymerase beta thumb, putative 0.009 0.0186 0.0986
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0005 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0226 0.0596 0.0806
Loa Loa (eye worm) hypothetical protein 0.0293 0.0797 0.1079
Loa Loa (eye worm) hypothetical protein 0.0293 0.0797 0.1079
Loa Loa (eye worm) inositol-1 0.0076 0.0143 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0005 0.0007
Onchocerca volvulus Cathepsin L homolog 0.0087 0.0175 0.0793
Brugia malayi jmjC domain containing protein 0.0035 0.0018 0.0024
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0048 0.0058 0.0244
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.012
Echinococcus granulosus zinc finger protein 0.0073 0.0134 0.0177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0214 0.0557 0.0554
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0018 0.0024
Brugia malayi Probable ClpP-like protease 0.008 0.0154 0.0208
Plasmodium vivax hypothetical protein, conserved 0.0293 0.0797 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0147 0.0358 0.0354
Brugia malayi beta-lactamase family protein 0.0293 0.0797 0.1079
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0168 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0084
Mycobacterium tuberculosis Probable hydrolase 0.0293 0.0797 0.1414
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0404 0.0401
Echinococcus granulosus expressed conserved protein 0.0185 0.047 0.0632
Echinococcus multilocularis lamin 0.0226 0.0596 0.0592
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.012
Brugia malayi MH2 domain containing protein 0.0035 0.002 0.0027
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.007 0.0094
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0154 0.114
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0018 0.0074
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.0807
Echinococcus multilocularis Niemann Pick C1 protein 0.0281 0.0761 0.0757
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0114 0.0257 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0087 0.0175 0.0797
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0033 0.0012 0.0008
Echinococcus multilocularis kinesin family 1 0.2049 0.609 0.6088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Schistosoma mansoni ap endonuclease 0.0039 0.0031 0.0043
Schistosoma mansoni lamin 0.0226 0.0596 0.0806
Loa Loa (eye worm) acetyltransferase 0.0299 0.0816 0.1104
Echinococcus multilocularis protein dispatched 1 0.0096 0.0204 0.02
Brugia malayi nuclear hormone receptor 0.003 0.0005 0.0007
Leishmania major cathepsin L-like protease 0.0087 0.0175 0.0882
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0256 0.0347
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0087 0.0175 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0013 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Echinococcus multilocularis zinc finger protein 0.0073 0.0134 0.0131
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0006 0.0033
Toxoplasma gondii cathepsin CPL 0.0087 0.0175 0.2091
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0161 0.0873
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0075 0.014 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0171 0.0778
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0143 0.1241
Schistosoma mansoni aldehyde dehydrogenase 0.0302 0.0823 0.1114
Echinococcus granulosus cathepsin L cysteine proteinase 0.0087 0.0175 0.0232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0302 0.0823 0.8773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.0071 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0005 0.0007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0018 0.0167
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0256 0.0253
Loa Loa (eye worm) hypothetical protein 0.0109 0.0243 0.0329
Schistosoma mansoni hypothetical protein 0.0214 0.0557 0.0754
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.03 0.0402
Trypanosoma brucei hypothetical protein, conserved 0.0208 0.054 0.2905
Loa Loa (eye worm) RNA binding protein 0.0342 0.0943 0.1277
Loa Loa (eye worm) MH2 domain-containing protein 0.0519 0.1478 0.2
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0143 0.0345 0.0466
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0144 0.0348 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0005 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.091 0.492
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0643 0.1851 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.0583 0.079
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.248 0.7389 1
Leishmania major hypothetical protein, conserved 0.0035 0.0018 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0345 0.0466
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0058 0.0314
Loa Loa (eye worm) intermediate filament protein 0.0226 0.0596 0.0806
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0034 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0342 0.0943 0.1277
Brugia malayi RNA binding protein 0.0342 0.0943 0.1277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0024
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0048 0.0058 0.0054
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0031 0.0033
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0293 0.0797 0.1414
Mycobacterium ulcerans esterase/lipase LipP 0.0293 0.0797 0.8489
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0022 0.005
Mycobacterium tuberculosis Probable lipase LipD 0.0293 0.0797 0.1414
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0058 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0005 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0168 0.0222
Brugia malayi PHD-finger family protein 0.0032 0.001 0.0013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0121 0.0279 0.0378
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0151 0.2065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0087 0.0175 0.0797
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0031 0.1013
Echinococcus granulosus beta LACTamase domain containing family member 0.0293 0.0797 0.1075
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0129
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0048 0.0594
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0163 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0034 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0005 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.091 0.492
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.0707 0.0957
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0025 0.0021
Leishmania major cathepsin L-like protease 0.0331 0.091 0.4884
Echinococcus granulosus lysine specific demethylase 5A 0.0142 0.0341 0.0457
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0219
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0006 0.0028
Brugia malayi ecdysteroid receptor 0.003 0.0005 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0031 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0048 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0058 0.0251
Echinococcus multilocularis lamin dm0 0.0226 0.0596 0.0592
Loa Loa (eye worm) hypothetical protein 0.0226 0.0596 0.0806
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0018 0.0024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0087 0.0175 0.2407
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0143 0.0775
Schistosoma mansoni inositol monophosphatase 0.0076 0.0143 0.0194
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0302 0.0823 0.4408
Schistosoma mansoni bromodomain containing protein 0.0206 0.0534 0.0723
Schistosoma mansoni inositol monophosphatase 0.0076 0.0143 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0256 0.1176
Echinococcus granulosus cathepsin L 0.0045 0.0048 0.006
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0256 0.2492
Echinococcus granulosus microtubule associated protein 2 0.2178 0.6478 0.8767
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0031 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0058 0.0251
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0071 0.0067
Brugia malayi jmjC domain containing protein 0.0252 0.0673 0.0911
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0143 0.0345 0.1845
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0143 0.0649
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0102 0.0138
Brugia malayi Pre-SET motif family protein 0.0652 0.1877 0.2541
Onchocerca volvulus 0.0147 0.0358 0.1646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0024
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0018 0.0019
Echinococcus granulosus tar DNA binding protein 0.0342 0.0943 0.1272
Schistosoma mansoni smad1 5 8 and 0.0035 0.002 0.0027
Leishmania major hypothetical protein, conserved 0.0046 0.0053 0.0219
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0068 0.0117 0.0615
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0175 0.2382
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0087 0.0175 0.0237
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0031 0.0357
Schistosoma mansoni patched 1 0.0084 0.0168 0.0227
Echinococcus granulosus intermediate filament protein 0.0226 0.0596 0.0802
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0256 0.0438
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0084
Loa Loa (eye worm) hypothetical protein 0.0293 0.0797 0.1079
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.007 0.0094
Leishmania major hypothetical protein, conserved 0.0208 0.054 0.2869
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0005 0.0007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0302 0.0823 0.1109
Leishmania major cathepsin L-like protease 0.0087 0.0175 0.0882
Plasmodium vivax vivapain-2 0.0087 0.0175 0.2197
Loa Loa (eye worm) hypothetical protein 0.0214 0.0557 0.0754
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0707 0.3279
Toxoplasma gondii hypothetical protein 0.0104 0.0226 0.2711
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0048 0.0594
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0022 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0013 0.0009
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0143 0.0649
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.002 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0161 0.2214
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 1
Brugia malayi Fli-1 protein 0.0215 0.056 0.0758
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0031 0.0037
Echinococcus multilocularis geminin 0.1061 0.3111 0.3108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0675 0.1949 0.2637
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0005 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0022 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0345 0.1587
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0058 0.0294
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0143 0.0345 0.4768
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0005 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0005 0.0007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0087 0.0175 0.2407
Schistosoma mansoni hypothetical protein 0.0081 0.0159 0.0215
Echinococcus granulosus Niemann Pick C1 protein 0.0281 0.0761 0.1025
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0047 0.0055 0.007
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0058 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.0662
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0161 0.0873
Entamoeba histolytica hypothetical protein 0.0108 0.0238 0.3262
Mycobacterium tuberculosis Conserved hypothetical protein 0.0339 0.0934 0.166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.0202 0.0273
Schistosoma mansoni alpha-glucosidase 0.014 0.0336 0.0455
Loa Loa (eye worm) hypothetical protein 0.0293 0.0797 0.1079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0293 0.0797 0.8489
Echinococcus multilocularis survival motor neuron protein 1 0.0707 0.2044 0.2041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0143 0.0345 0.4768
Brugia malayi Cathepsin L-like precursor 0.0087 0.0175 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0252 0.0673 0.0906
Brugia malayi hypothetical protein 0.0707 0.2044 0.2766
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0045 0.0048 0.0261
Giardia lamblia PHD finger protein 15 0.0059 0.0092 0.1217
Entamoeba histolytica hypothetical protein 0.0108 0.0238 0.3262
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0052 0.007 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0256 0.1176
Brugia malayi cytoplasmic intermediate filament protein 0.0121 0.0279 0.0378
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0151 0.2039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Echinococcus granulosus smad 0.0035 0.002 0.0022
Schistosoma mansoni importin beta-1 0.003 0.0004 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0092 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0022 0.0121
Mycobacterium ulcerans hypothetical protein 0.0293 0.0797 0.8489
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.248 0.7389 0.7388
Brugia malayi F/Y-rich N-terminus family protein 0.0065 0.0108 0.0147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0171 0.0778
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0214 0.0557 0.0554
Brugia malayi indoleamine 2,3-dioxygenase 0.248 0.7389 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0005 0.0007
Loa Loa (eye worm) cysteine protease 0.0087 0.0175 0.0237
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0022 0.0084
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0161 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0048 0.0205
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0643 0.1851 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0175 0.0797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0048 0.0241
Onchocerca volvulus Cathepsin F homolog 0.0087 0.0175 0.0793
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0005 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0005 0.0007
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0256 0.3526
Mycobacterium tuberculosis Conserved protein 0.0293 0.0797 0.1414
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0238 0.0317
Mycobacterium ulcerans hypothetical protein 0.0339 0.0934 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0048 0.0058 0.0294
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0018 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0089 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0119 0.0665
Plasmodium vivax vivapain-2 0.0087 0.0175 0.2197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.0662
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0707 0.3279
Schistosoma mansoni tar DNA-binding protein 0.0342 0.0943 0.1277
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.0797 0.3701
Plasmodium vivax importin-beta 2, putative 0.003 0.0004 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0154 0.0203
Loa Loa (eye worm) hypothetical protein 0.0116 0.0265 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0005 0.0007
Loa Loa (eye worm) kinesin-like protein KLP2 0.0266 0.0716 0.0969
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0154 0.1831
Brugia malayi Pre-SET motif family protein 0.0096 0.0202 0.0273
Loa Loa (eye worm) hypothetical protein 0.0255 0.0681 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0005 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0238 0.0322
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0175 0.0947
Loa Loa (eye worm) hypothetical protein 0.0105 0.023 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0092 0.116
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0005 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.0506 0.068
Brugia malayi PHD-finger family protein 0.0089 0.0183 0.0248
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Echinococcus multilocularis smad 0.0035 0.002 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0031 0.0127
Loa Loa (eye worm) fibroinase 0.0087 0.0175 0.0237
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.0392 0.0389
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Echinococcus multilocularis snurportin 1 0.032 0.0878 0.0874
Schistosoma mansoni hypothetical protein 0.248 0.7389 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0143 0.0775
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0022 0.0084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0005 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0006 0.0008
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0154 0.015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0031 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0018 0.0024
Schistosoma mansoni hypothetical protein 0.1783 0.5287 0.7156
Onchocerca volvulus 0.0293 0.0797 0.3698
Trypanosoma cruzi cysteine protease, putative 0.0045 0.0048 0.0261
Brugia malayi isocitrate dehydrogenase 0.0033 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0081 0.0159 0.0215
Echinococcus multilocularis cpg binding protein 0.013 0.0307 0.0303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0246 0.0655 0.0651
Brugia malayi Bromodomain containing protein 0.0242 0.0642 0.0868
Echinococcus granulosus peregrin 0.0074 0.0136 0.0179
Brugia malayi jmjC domain containing protein 0.0035 0.0018 0.0024
Plasmodium vivax kinesin-5 0.0266 0.0716 0.8976
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.0506 0.7048
Plasmodium vivax vivapain-1 0.0045 0.0048 0.0606
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.0506 0.0503
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0013 0.0114
Trichomonas vaginalis esterase, putative 0.0293 0.0797 0.3701
Brugia malayi CXXC zinc finger family protein 0.0118 0.0269 0.0364
Echinococcus granulosus Smad4 0.0035 0.002 0.0022
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0025 0.0028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0047 0.0055 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.0797 0.3701
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0256 0.1385
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0031 0.017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0143 0.0649
Trypanosoma brucei hypothetical protein, conserved 0.0293 0.0797 0.4298
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.0093 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0058 0.0251
Echinococcus granulosus histone lysine methyltransferase setb 0.0147 0.0358 0.0479
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0022 0.003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.002 0.0016
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0878 0.1188
Onchocerca volvulus 0.0255 0.0681 0.3155
Leishmania major cathepsin L-like protease 0.0331 0.091 0.4884
Schistosoma mansoni smad1 5 8 and 0.0035 0.002 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0005 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0109 0.0243 0.0324
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1874 0.5561 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0256 0.1176
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0143 0.0345 0.1845
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0304 0.083 0.4447
Loa Loa (eye worm) hypothetical protein 0.0707 0.2044 0.2766
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0128 0.03 0.0407
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0005 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Brugia malayi intermediate filament protein 0.0226 0.0596 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Brugia malayi 6-phosphofructokinase 0.0114 0.0256 0.0347
Brugia malayi beta-lactamase 0.0293 0.0797 0.1079
Brugia malayi jmjC domain containing protein 0.0035 0.0018 0.0024
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0018 0.0014
Echinococcus granulosus dnaJ subfamily B 0.0428 0.1204 0.1625
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0304 0.083 0.4486
Onchocerca volvulus Cathepsin L homolog 0.0087 0.0175 0.0793
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0252 0.0673 0.067
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Echinococcus granulosus histone acetyltransferase KAT2B 0.0284 0.0769 0.1036
Schistosoma mansoni aldehyde dehydrogenase 0.0302 0.0823 0.1114
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.03 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0293 0.0797 0.3701
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0404 0.0547
Plasmodium vivax JmjC domain containing protein 0.0035 0.0018 0.022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0005 0.0002
Schistosoma mansoni cathepsin F (C01 family) 0.0087 0.0175 0.0237
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.1061 0.3111 0.421
Echinococcus multilocularis microtubule associated protein 2 0.2178 0.6478 0.6477
Mycobacterium ulcerans aldehyde dehydrogenase 0.0302 0.0823 0.8773
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Mycobacterium ulcerans aldehyde dehydrogenase 0.0302 0.0823 0.8773
Onchocerca volvulus Alhambra homolog 0.0059 0.0092 0.0407
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.032 0.0878 0.1188
Schistosoma mansoni cellular tumor antigen P53 0.0255 0.0681 0.0922
Toxoplasma gondii exonuclease III APE 0.0039 0.0031 0.0338
Brugia malayi Ets-domain containing protein 0.0071 0.0127 0.0171
Mycobacterium ulcerans lipase LipD 0.0293 0.0797 0.8489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0246 0.0655 0.0886
Brugia malayi hypothetical protein 0.0082 0.0161 0.0219
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0143 0.0345 0.0341
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0013 0.0071
Schistosoma mansoni hypothetical protein 0.0214 0.0557 0.0754
Loa Loa (eye worm) hypothetical protein 0.0462 0.1305 0.1766
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0195 0.0502 0.0498
Brugia malayi jmjC domain containing protein 0.0142 0.0341 0.0462
Trichomonas vaginalis penicillin-binding protein, putative 0.0293 0.0797 0.3701
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0202 0.0198
Onchocerca volvulus 0.0293 0.0797 0.3698
Brugia malayi MH2 domain containing protein 0.0519 0.1478 0.2
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0256 0.1176
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0005 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0462 0.2137
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.0707 0.0957
Onchocerca volvulus 0.0087 0.0175 0.0793
Brugia malayi hypothetical protein 0.0108 0.0238 0.0322
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0246 0.0655 0.0886
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0151 0.2039
Mycobacterium tuberculosis Probable lipase LipE 0.0293 0.0797 0.1414
Schistosoma mansoni hypothetical protein 0.0462 0.1305 0.1766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0013 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0283 0.0383
Brugia malayi Kinesin motor domain containing protein 0.0266 0.0716 0.0969
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0434 0.2006
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0018 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0031 0.017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0214 0.0557 0.075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Schistosoma mansoni smad 0.0035 0.002 0.0027
Entamoeba histolytica cysteine proteinase 1, putative 0.0045 0.0048 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0293 0.0797 0.4309
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0005 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0005 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0087 0.0175 0.0171
Brugia malayi Ets-domain containing protein 0.0071 0.0127 0.0171
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0214 0.0557 0.075
Echinococcus multilocularis expressed conserved protein 0.0185 0.047 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0345 0.1587
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0022 0.0227
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0226 0.0596 0.0806
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0163 0.0215
Schistosoma mansoni hypothetical protein 0.0214 0.0557 0.0754
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0013 0.0131
Schistosoma mansoni smad1 5 8 and 0.0035 0.002 0.0027
Schistosoma mansoni microtubule-associated protein tau 0.2178 0.6478 0.8768
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0143 0.1935
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0022 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0147 0.0358 0.0484
Loa Loa (eye worm) hypothetical protein 0.0117 0.0267 0.0361
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0013 0.0165
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0048 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0675 0.1949 0.2637
Trypanosoma cruzi ISWI complex protein 0.0046 0.0053 0.0289
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 0.1356
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0127 0.0166
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.248 0.7389 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0018 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.0186 0.1004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0241 0.064 0.7769
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0175 0.2382
Echinococcus granulosus cathepsin L cysteine protease 0.0045 0.0048 0.006
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.002 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Brugia malayi RNA, U transporter 1 0.0085 0.017 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0005 0.0007
Entamoeba histolytica hypothetical protein 0.0108 0.0238 0.3262
Schistosoma mansoni tar DNA-binding protein 0.0342 0.0943 0.1277
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0048 0.0058 0.0073
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0075 0.014 0.019
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0013 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0293 0.0797 0.1414
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0143 0.0345 0.1803
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0404 0.0401
Loa Loa (eye worm) hypothetical protein 0.0084 0.0168 0.0227
Echinococcus granulosus survival motor neuron protein 1 0.0707 0.2044 0.2762
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0092 0.0125
Onchocerca volvulus 0.0096 0.0202 0.0917
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.054 0.292
Brugia malayi MH2 domain containing protein 0.0035 0.002 0.0027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0202 0.2417
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0293 0.0797 0.1079
Onchocerca volvulus 0.0118 0.0269 0.123
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0013 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0293 0.0797 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0005 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0293 0.0797 0.1414
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0302 0.0824 0.4452
Toxoplasma gondii aldehyde dehydrogenase 0.0302 0.0823 1
Echinococcus granulosus phd:f box containing protein 0.0035 0.0018 0.0019
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0256 0.0347
Schistosoma mansoni zinc finger protein 0.0073 0.0134 0.0182
Schistosoma mansoni hypothetical protein 0.0428 0.1204 0.1629
Leishmania major mitochondrial DNA polymerase beta 0.0643 0.1851 1
Onchocerca volvulus 0.0087 0.0175 0.0793
Brugia malayi CHE-14 protein 0.0084 0.0168 0.0227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0214 0.0557 0.0754
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0058 0.0079
Echinococcus multilocularis protein patched 0.0084 0.0168 0.0164
Schistosoma mansoni ap endonuclease 0.0039 0.0031 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0005 0.0007
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0058 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0202 0.0273
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0194 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.091 0.4909
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0089 0.1163
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0154 0.1929
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0006 0.0033
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0013 0.0051
Echinococcus granulosus cathepsin l1 0.0058 0.0089 0.0115
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0143 0.0189
Echinococcus granulosus fetal alzheimer antigen falz 0.0075 0.014 0.0184
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.0662
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Brugia malayi Bromodomain containing protein 0.0074 0.0136 0.0184
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0018 0.0095
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0154 0.2107
Brugia malayi MH1 domain containing protein 0.0035 0.002 0.0027
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0006 0.0028
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0143 0.0345 0.0461
Brugia malayi nuclear receptor NHR-88 0.003 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.0154 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.066
Brugia malayi Latrophilin receptor protein 2 0.0214 0.0557 0.0754
Onchocerca volvulus 0.0226 0.0596 0.2757
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0092 0.1082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0005 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0193 0.0882
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0006 0.0077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0059 0.0092 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0203 0.0925
Plasmodium vivax SET domain protein, putative 0.0096 0.0202 0.2531
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0022 0.0084
Giardia lamblia GTOR 0.0143 0.0345 0.4768
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0345 0.0466
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0256 0.1176
Schistosoma mansoni Smad4 0.0035 0.002 0.0027
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0109 0.0242 0.0323
Trypanosoma cruzi cysteine proteinase, putative 0.0045 0.0048 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0168 0.0766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0147 0.0358 0.0484
Mycobacterium ulcerans beta-lactamase 0.0293 0.0797 0.8489
Echinococcus granulosus geminin 0.1061 0.3111 0.4207
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0006 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0342 0.0943 0.1277
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0392 0.0531
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0022 0.003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0154 0.1831
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0087 0.0175 0.0171
Echinococcus granulosus tumor protein p63 0.174 0.5158 0.698
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0293 0.0797 0.1079
Echinococcus multilocularis peregrin 0.0074 0.0136 0.0132
Loa Loa (eye worm) hypothetical protein 0.0293 0.0797 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0256 0.1324
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0022 0.023
Brugia malayi phosphofructokinase 0.0114 0.0256 0.0347
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0071 0.0104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0142 0.0341 0.0462
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0143 0.0345 0.1803
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0404 0.0547
Schistosoma mansoni hypothetical protein 0.248 0.7389 1
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0048 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0234 0.1072
Brugia malayi RNA recognition motif domain containing protein 0.0342 0.0943 0.1277
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0168 0.0763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0175 0.0797
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.091 0.492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0058 0.0251
Entamoeba histolytica cysteine proteinase 2 0.0045 0.0048 0.0594
Entamoeba histolytica cysteine protease, putative 0.0045 0.0048 0.0594
Leishmania major cathepsin L-like protease 0.0087 0.0175 0.0882
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0018 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0006 0.0008
Echinococcus multilocularis tumor protein p63 0.174 0.5158 0.5157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0515 0.0698
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0246 0.0655 0.0881
Echinococcus granulosus GPCR family 2 0.0214 0.0557 0.075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0109 0.0242 0.0239
Loa Loa (eye worm) hypothetical protein 0.0131 0.0308 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0146 0.066
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0048 0.0594
Entamoeba histolytica cysteine protease, putative 0.0087 0.0175 0.2382

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.9 uM Antileishmanial activity against Leishmania donovani MHOM/SD/001S-2D promastigotes after 72 hrs by MTT assay ChEMBL. 20617807
LC50 (functional) = 2.8 uM Antileishmanial activity against Leishmania donovani MHOM/SD/001S-2D promastigotes after 72 hrs by MTT assay ChEMBL. 20617807

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania donovani ChEMBL23 20617807

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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