Detailed information for compound 1191515

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.487 | Formula: C25H27NO2
  • H donors: 1 H acceptors: 2 LogP: 2.54 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1=CCN(CC1)C1CCC2(C1)Cc1ccccc1Cc1c2cccc1
  • InChi: 1S/C25H27NO2/c27-24(28)18-10-13-26(14-11-18)22-9-12-25(17-22)16-21-7-2-1-5-19(21)15-20-6-3-4-8-23(20)25/h1-8,10,22H,9,11-17H2,(H,27,28)
  • InChiKey: VFKIKYZNUCGJGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0034 0.0115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0076 0.012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0034 0.0054
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0006 0.0005
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0008 0.0006 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.1311 0.2082
Brugia malayi neuropeptide F receptor 0.0011 0.0034 0.0071
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.9534
Echinococcus multilocularis 0.0008 0.0005 0.0008
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.9534
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0034 0.0054
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0004 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0085 0.0181
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.1246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Schistosoma mansoni ferritin 0.0009 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0085 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Brugia malayi G-protein alpha subunit 0.0008 0.0006 0.0005
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.0006 0.001
Schistosoma mansoni ap endonuclease 0.0018 0.0085 0.0289
Brugia malayi MAP kinase sur-1 0.0053 0.0349 0.0821
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni hypothetical protein 0.0011 0.0034 0.0115
Loa Loa (eye worm) cytochrome P450 0.0008 0.0005 0.0006
Brugia malayi beta-lactamase family protein 0.0038 0.0231 0.0541
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0011 0.0034 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Echinococcus granulosus g protein coupled receptor 0.0011 0.0034 0.0054
Onchocerca volvulus 0.0038 0.0231 0.193
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0225 0.1211
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0004 0.0007
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0004 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.1761 0.1757
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0008 0.0005 0.0001
Schistosoma mansoni hypothetical protein 0.0011 0.0034 0.0115
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0008 0.0005 0.0003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0034 0.0054
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0006 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0034 0.0115
Onchocerca volvulus 0.0011 0.0034 0.0253
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Schistosoma mansoni neuropeptide receptor 0.0011 0.0034 0.0115
Brugia malayi Cytochrome P450 family protein 0.0008 0.0005 0.0003
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0008 0.0005 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0349 0.0771
Schistosoma mansoni opsin-like receptor 0.0011 0.0034 0.0115
Brugia malayi larval opioid receptor 0.0011 0.0034 0.0071
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0008 0.0005 0.0001
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0034 0.0253
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0034 0.0054
Onchocerca volvulus 0.0011 0.0034 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0349 0.0551
Echinococcus granulosus ferritin 0.0009 0.0012 0.002
Echinococcus granulosus neuropeptide receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) acetyltransferase 0.0141 0.1007 0.5494
Echinococcus granulosus serotonin receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni cytochrome P450 0.0008 0.0005 0.0018
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0354 0.0831
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0977 0.1551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.1311 0.4449
Mycobacterium ulcerans beta-lactamase 0.0038 0.0231 0.0227
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0034 0.0115
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0006 0.0021
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0008 0.0006 0.0012
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0034 0.0054
Mycobacterium ulcerans hypothetical protein 0.0038 0.0231 0.0227
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0231 0.0786
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0012 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.1311 0.7162
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0259 0.3778
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0034 0.0071
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0034 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0085 0.0192
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni hypothetical protein 0.0017 0.0076 0.0258
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0004 0.0014
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.9534
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0034 0.0054
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0034 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Schistosoma mansoni amine GPCR 0.0011 0.0034 0.0115
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0034 0.0054
Brugia malayi Dopamine receptor 0.0011 0.0034 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0008 0.0005 0.0001
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0022 0.0041
Schistosoma mansoni apoferritin-2 0.0009 0.0012 0.0042
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0006 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0034 0.0164
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0034 0.0164
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0005 0.0018
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0004 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1829 1
Echinococcus granulosus g protein coupled receptor 0.0011 0.0034 0.0054
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0896 0.212
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0034 0.0054
Trichomonas vaginalis ferritin, putative 0.0009 0.0012 0.0046
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0231 0.0227
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0008 0.0005 0.0001
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0006 0.0021
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0349 0.0551
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Mycobacterium leprae Probable lipase LipE 0.0038 0.0231 0.0227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0008 0.0005 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0395
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Toxoplasma gondii hypothetical protein 0.0097 0.0679 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0008 0.0005 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0008 0.0005 0.0001
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0233 1
Brugia malayi Serotonin receptor 0.0011 0.0034 0.0071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0022 0.0148
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0231 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Onchocerca volvulus 0.0011 0.0034 0.0253
Brugia malayi TAR-binding protein 0.0126 0.0896 0.212
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0231 0.0227
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0034 0.0054
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0034 0.0071
Echinococcus granulosus fmrfamide receptor 0.0011 0.0034 0.0054
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0006 0.0021
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0012 0.0008
Brugia malayi Dopamine receptor protein 1 0.0011 0.0034 0.0071
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0008 0.0005 0.0001
Onchocerca volvulus 0.0038 0.0231 0.193
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0034 0.0054
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0004 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0095
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0034 0.0115
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0008 0.0005 0.0001
Leishmania major mitochondrial DNA polymerase beta 0.0603 0.4481 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0008 0.0005 0.0001
Brugia malayi beta-lactamase 0.0038 0.0231 0.0541
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0034 0.0054
Brugia malayi neuropeptide F receptor 0.0011 0.0034 0.0071
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0004 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0034 0.0054
Onchocerca volvulus 0.0008 0.0006 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0041
Schistosoma mansoni biogenic amine receptor 0.0011 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0005 0.0006
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0233 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0085 0.0181
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0034 0.0071
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0034 0.0054
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0006 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1248 0.6819
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0034 0.0164
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0004 0.0007
Mycobacterium leprae Conserved hypothetical protein 0.0008 0.0005 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0095
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0034 0.0054
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0008 0.0005 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0285 0.2093 0.4666
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0231 0.0227
Leishmania major cytochrome p450-like protein 0.0017 0.0077 0.0162
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0006 0.0005
Brugia malayi ecdysteroid receptor 0.001 0.0022 0.0041
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0012 0.0008
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0231 0.0227
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0005 0.0003
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0034 0.0115
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0076 0.0121
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus granulosus orexin receptor type 2 0.0011 0.0034 0.0054
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1007 0.1588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.1311 0.2068
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0034 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0034 0.0054
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0896 0.4887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.1311 0.2068
Mycobacterium ulcerans TetR family transcriptional regulator 0.1337 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0076 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0005 0.0003
Schistosoma mansoni ferritin 0.0009 0.0012 0.0042
Brugia malayi nuclear receptor NHR-88 0.001 0.0022 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0013 0.002
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0034 0.0115
Brugia malayi G-protein coupled receptor 0.0011 0.0034 0.0071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0349 0.1186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0349 0.1892
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0034 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0008 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0034 0.0054
Schistosoma mansoni hypothetical protein 0.0017 0.0076 0.0258
Echinococcus granulosus expressed protein 0.0008 0.0006 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0076 0.0395
Trypanosoma brucei protein kinase, putative 0.0053 0.0349 0.0771
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0034 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0034 0.0164
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0034 0.0071
Brugia malayi sulfakinin receptor protein 0.0011 0.0034 0.0071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0034 0.0115
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0034 0.0054
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Brugia malayi steroid hormone receptor 0.001 0.0022 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0008 0.0005 0.0001
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Mycobacterium tuberculosis Conserved protein 0.0038 0.0231 0.0227
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Schistosoma mansoni myosin xvIII 0.0011 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0603 0.4481 1
Brugia malayi RNA binding protein 0.0126 0.0896 0.212
Schistosoma mansoni neuropeptide receptor 0.0011 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0349 0.0771
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0034 0.0164
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.6211 0.9798
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0004 0.0007
Echinococcus granulosus hypothetical protein 0.0008 0.0004 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0008 0.0005 0.0001
Brugia malayi hypothetical protein 0.0008 0.0006 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Echinococcus granulosus cpg binding protein 0.003 0.017 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0585 0.1298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0041
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0004 0.0007
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0004 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0008 0.0005 0.0001
Schistosoma mansoni hypothetical protein 0.0017 0.0076 0.0258
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0085 0.0444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0034
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0034 0.0115
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0006 0.001
Leishmania major hypothetical protein, conserved 0.0038 0.0231 0.0508
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0004 0.0007
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0012 0.0008
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0004 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0896 0.4887
Schistosoma mansoni hypothetical protein 0.0037 0.0222 0.0755
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0008 0.0005 0.0001
Schistosoma mansoni ap endonuclease 0.0018 0.0085 0.0289
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0004 0.0007
Loa Loa (eye worm) RNA binding protein 0.0126 0.0896 0.4887
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0896 0.3041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0004 0.0007
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0008 0.0005 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0231 0.1246
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0259 0.0411
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0008 0.0005 0.0001
Echinococcus multilocularis oxidoreductase 0.0008 0.0004 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0231 0.0227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0022 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0231 0.0365
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0585 0.1298
Schistosoma mansoni histamine h1 receptor 0.0011 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0349 0.0771
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0076 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0034 0.0054
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0004 0.0007
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0006 0.001
Brugia malayi GnHR receptor homolog 0.0011 0.0034 0.0071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0085 0.2345
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0578
Schistosoma mansoni amine GPCR 0.0011 0.0034 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1829 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0022 0.0073
Schistosoma mansoni cpg binding protein 0.0028 0.0158 0.0537
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0022 0.0073
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0008 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0034 0.0071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0022 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0034 0.0115
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0012
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0006 0.001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0034 0.0115
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0085 0.0444
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0085 0.0181
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0034 0.0164
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0006 0.0021
Onchocerca volvulus 0.0008 0.0006 0.0018
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0034 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0022 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.2093 0.4666
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0034 0.0054
Schistosoma mansoni neuropeptide receptor 0.0011 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0077 0.0162
Schistosoma mansoni nuclear hormone receptor 0.001 0.0022 0.0073
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0349 0.1892
Onchocerca volvulus 0.0028 0.0158 0.1308
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0006 0.0021
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0006 0.001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0034 0.0115
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Schistosoma mansoni neuropeptide receptor 0.0011 0.0034 0.0115
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Brugia malayi nuclear hormone receptor 0.001 0.0022 0.0041
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0034 0.0054
Toxoplasma gondii ABC1 family protein 0.0038 0.0231 0.3369
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0259 0.1397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0095
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0231 0.0508
Mycobacterium leprae putative cytochrome p450 0.0008 0.0005 0.0001
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0034 0.0164
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0077 0.0397
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0008 0.0005 0.0001
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.9534
Brugia malayi Cytochrome P450 family protein 0.0017 0.0077 0.0172
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0006 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0085 0.3535
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0231 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0231 0.1246
Brugia malayi ORL1-like opioid receptor 0.0011 0.0034 0.0071
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.0006 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0008 0.0005 0.0001
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0004 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0013 0.002
Echinococcus multilocularis GPCR, family 2 0.0017 0.0076 0.012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0008 0.0006 0.0012
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0349 0.0771
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0022 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0008 0.0005 0.0001
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0006 0.0021
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0034 0.0054
Echinococcus granulosus neuropeptide receptor 0.0011 0.0034 0.0054
Onchocerca volvulus 0.0011 0.0034 0.0253
Mycobacterium tuberculosis Conserved protein 0.0038 0.0231 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0022 0.0034
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0005 0.0003
Onchocerca volvulus 0.0011 0.0034 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0085 0.0081
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0008 0.0005 0.0001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0034 0.0054
Brugia malayi cytochrome P450 0.0008 0.0005 0.0003
Loa Loa (eye worm) beta-lactamase 0.0038 0.0231 0.1246
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0034 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0041
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0006 0.0005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0034
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0004 0.0007
Schistosoma mansoni carbonyl reductase 0.0008 0.0004 0.0014
Echinococcus granulosus dnaJ subfamily B 0.0399 0.2946 0.4678
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0231 0.0368
Schistosoma mansoni carbonyl reductase 0.0008 0.0004 0.0014
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0022 0.0034
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0008 0.0005 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0034 0.0054
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0008 0.0006 0.0012
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Entamoeba histolytica G protein alpha subunit, putative 0.0008 0.0006 0.0092
Schistosoma mansoni opsin-like receptor 0.0011 0.0034 0.0115
Onchocerca volvulus 0.001 0.0022 0.0148
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0034 0.0054
Brugia malayi Dopamine receptor protein 2 0.0011 0.0034 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0349 0.1892
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.6339 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0034
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0222 0.0353
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0034 0.0115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0022 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0225 0.0526
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0022 0.0034
Schistosoma mansoni biogenic amine receptor 0.0011 0.0034 0.0115
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.0082
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0034 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0222 0.0351
Echinococcus granulosus FTZ F1 alpha 0.001 0.0022 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0896 0.3041
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0231 0.0508
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0896 0.1413
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0085 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0231 0.0227
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0004 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0349 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0158 0.0845
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0005 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0231 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0349 0.1892
Onchocerca volvulus 0.0011 0.0034 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0231 0.8918
Echinococcus granulosus g protein coupled receptor 0.0011 0.0034 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0354 0.0831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Brugia malayi Serotonin receptor 0.0567 0.421 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis serotonin receptor 0.0011 0.0034 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0349 0.1892
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1829 1
Onchocerca volvulus 0.0011 0.0034 0.0253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0373 0.5459
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0231 0.1246
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0034 0.0054
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0008 0.0005 0.0001
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0006 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0233 0.6634
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0022 0.0095
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0006 0.0005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0259 0.3778
Echinococcus granulosus allatostatin A receptor 0.0011 0.0034 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0008 0.0005 0.0001
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0349 0.5115
Echinococcus multilocularis cpg binding protein 0.003 0.017 0.0269
Onchocerca volvulus 0.0011 0.0034 0.0253
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0085 0.0081
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.0006 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0012 0.0019
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0085 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0222 0.0755
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0034 0.0054
Schistosoma mansoni hypothetical protein 0.0008 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1829 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0585 0.1298
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0008 0.0005 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0034 0.0054
Brugia malayi Cytochrome P450 family protein 0.0008 0.0005 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0022 0.0073
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0034 0.0115
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0004 0.0007
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0004 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0231 0.0227
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0022 0.0034
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0004 0.0014
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0008 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0076 0.0171
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0006 0.0012
Mycobacterium ulcerans hypothetical protein 0.0318 0.2336 0.2333
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0085 0.3175
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0034 0.0164
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0006 0.001
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0008 0.0005 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0034 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0231 0.0508
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0349 0.0555
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0034 0.0115
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0077 0.0073
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0034 0.0115
Brugia malayi hypothetical protein 0.0037 0.0222 0.0519
Schistosoma mansoni ferritin 0.0009 0.0012 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.1311 0.4449
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0004 0.0014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1007 0.3416
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.0006 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0008 0.0005 0.0001
Schistosoma mansoni ferritin light chain 0.0009 0.0012 0.0042
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Echinococcus granulosus sex peptide receptor 0.0011 0.0034 0.0054
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.0006 0.001
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0041
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0006 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.1311 0.3107
Brugia malayi G protein-coupled receptor 0.0011 0.0034 0.0071
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0012
Schistosoma mansoni amine GPCR 0.0011 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.1246
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus granulosus tar DNA binding protein 0.0126 0.0896 0.1423
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0006 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0006 0.0021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0005 0.0003
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0008 0.0005 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0231 0.0541
Echinococcus granulosus hypothetical protein 0.0845 0.6297 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0012 0.1026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0034 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0008 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0034 0.0054
Schistosoma mansoni coup transcription factor 0.001 0.0022 0.0073
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0034 0.0054
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0006 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0896 0.3041
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0034 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0034
Schistosoma mansoni adenoreceptor 0.0011 0.0034 0.0115
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0259 1
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.1246
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1829 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0725 0.1609
Brugia malayi CXXC zinc finger family protein 0.0028 0.0158 0.0366
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.1829 0.4339
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0004 0.0007
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0006 0.001
Brugia malayi RE15519p 0.0011 0.0034 0.0071
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0008 0.0005 0.0001
Schistosoma mansoni amine GPCR 0.0011 0.0034 0.0115
Brugia malayi G-protein coupled receptor 0.0011 0.0034 0.0071
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0008 0.0005 0.0001
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0034 0.0054
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis serotonin receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0012
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0006 0.0021
Echinococcus multilocularis ferritin 0.0009 0.0012 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0095
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0022 0.0148
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0012
Echinococcus multilocularis expressed protein 0.0009 0.0012 0.002
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0008 0.0005 0.0001
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0022 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0034 0.0054
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0022 0.0148
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0076 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0077 0.0397
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0004 0.0007
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0006 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0034 0.0054
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0004 0.0007
Schistosoma mansoni amine GPCR 0.0011 0.0034 0.0115
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0034 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0896 0.3041
Echinococcus multilocularis expressed protein 0.0008 0.0006 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0022 0.0073
Onchocerca volvulus 0.0008 0.0006 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0231 0.1246
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0349 0.0771
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.1246
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0349 0.0771
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0012 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.1311 0.4449
Schistosoma mansoni opsin-like receptor 0.0011 0.0034 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0022 0.0041
Echinococcus granulosus GPCR family 2 0.0017 0.0076 0.0121
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0041
Schistosoma mansoni carbonyl reductase 0.0008 0.0004 0.0014
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0006 0.0021
Brugia malayi hypothetical protein 0.0011 0.0034 0.0071
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.2946 0.4648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0077 0.0397
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0034 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0085 0.0444
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0022 0.0034
Onchocerca volvulus 0.0011 0.0034 0.0253
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0004 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0034 0.0115
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0034 0.0253
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0034 0.0054
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1337 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0006 0.0012
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1007 0.2384
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0022 0.0041
Brugia malayi putative neuropeptide receptor 0.0011 0.0034 0.0071
Leishmania major cytochrome p450-like protein 0.0008 0.0005 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0394 0.1338
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0259 0.1397
Schistosoma mansoni ferritin light chain 0.0009 0.0012 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0231 0.1246
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0034 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0008 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0006 0.001
Echinococcus multilocularis sex peptide receptor 0.0011 0.0034 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0022 0.0034
Echinococcus multilocularis somatostatin receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.1246
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.2093 0.4666
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0034 0.0164
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0399 0.2946 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0073
Brugia malayi AKH receptor 0.0011 0.0034 0.0071
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1182 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0585 0.1298
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0034 0.0054
Onchocerca volvulus 0.0038 0.0231 0.193
Echinococcus granulosus somatostatin receptor 0.0011 0.0034 0.0054
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0076 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0896 0.3041
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0034 0.0054
Schistosoma mansoni hypothetical protein 0.0037 0.0225 0.0764
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0034 0.0164
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0085 0.0181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0231 0.0786
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0004 0.0007
Echinococcus granulosus expressed protein 0.0009 0.0012 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0231 0.1246
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0085 0.0135
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0034 0.0054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0022 0.0034
Onchocerca volvulus 0.0011 0.0034 0.0253
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Brugia malayi Cytochrome P450 family protein 0.0017 0.0077 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1248 0.6819
Brugia malayi beta-lactamase family protein 0.0038 0.0231 0.0541
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0034 0.0115
Trichomonas vaginalis esterase, putative 0.0038 0.0231 0.1246
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.1311 0.2082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Brugia malayi Melatonin receptor type 1A 0.0011 0.0034 0.0071
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.4481 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0318 0.2336 0.2333
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0349 0.0555
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0006 0.0021
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0349 0.0771
Echinococcus granulosus hypothetical protein 0.0008 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0354 0.1915
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0578
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.1246
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0034 0.0054
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0034 0.0054
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1829 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0008 0.0005 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0034 0.0115
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0008 0.0005 0.0001
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0034 0.0054
Schistosoma mansoni hypothetical protein 0.0011 0.0034 0.0115
Mycobacterium tuberculosis Conserved protein 0.0038 0.0231 0.0227
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0034 0.0054
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0013 0.0048
Mycobacterium ulcerans transcriptional regulator 0.1337 1 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0006 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0034 0.0115
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0085 0.3535
Schistosoma mansoni biogenic amine receptor 0.0011 0.0034 0.0115
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0354 0.1915
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1182 0.6455
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0164
Leishmania major cytochrome p450-like protein 0.0008 0.0005 0.0003
Schistosoma mansoni ferritin 0.0009 0.0012 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0077 0.0162
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.4481 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0006 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0041
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0034 0.0054
Onchocerca volvulus 0.0011 0.0034 0.0253
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.1829 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0004 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0095
Echinococcus granulosus oxidoreductase 0.0008 0.0004 0.0007
Mycobacterium ulcerans lipase LipD 0.0038 0.0231 0.0227
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0034 0.0071
Schistosoma mansoni apoferritin-2 0.0009 0.0012 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0077 0.0162
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0034 0.0054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0034 0.0054
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0008 0.0005 0.0001
Toxoplasma gondii exonuclease III APE 0.0018 0.0085 0.12
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0034

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) > 5.7 Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay ChEMBL. 20942472
Ki (functional) = 6.7 Antagonist activity at human 5HT2C receptor expressed in human SH-SY5Y cells by FLIPR assay ChEMBL. 20942472
Ki (functional) = 7.1 Antagonist activity at human 5HT2A receptor expressed in HEK cells assessed as inhibition of intracellular calcium accumulation by aequorin assay ChEMBL. 20942472
Ki (functional) = 7.4 Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay ChEMBL. 20942472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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