TDR Targets

Basic information

Technical information

TDR Targets ID: 1219086
Name: O2-[2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyr imidin-5-yl]-propylamino]-2-oxoethyl] O4-meth yl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
MW: 511.527 | Formula: C25H29N5O7
H donors: 3 H acceptors: 5 LogP: 2.01 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCCN(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)C(=O)COC(=O)c1[nH]c(c(c1C)C(=O)OC)C
InChi: 1S/C25H29N5O7/c1-5-11-29(17(31)13-37-24(34)19-14(2)18(15(3)27-19)23(33)36-4)20-21(26)30(25(35)28-22(20)32)12-16-9-7-6-8-10-16/h6-10,27H,5,11-13,26H2,1-4H3,(H,28,32,35)
InChiKey: UHCZJZGYEAKMTN-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

O2-[2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyrimidin-5-yl]-propyl-amino]-2-oxo-ethyl] O4-methyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid O2-[2-[[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-propylamino]-2-oxoethyl] O4-methyl ester
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid O2-[2-[[6-amino-1-(benzyl)-2,4-diketo-pyrimidin-5-yl]-propyl-amino]-2-keto-ethyl] O4-methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0032	0.0229	0.1957
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Brugia malayi	Protein kinase domain containing protein	0.001	0.0002	0.0009
Schistosoma mansoni	tubulin subunit alpha	0.0032	0.0229	0.0612
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0043	0.0349	0.0934
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0036	0.0277	0.0742
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0288	0.0899
Trichomonas vaginalis	tubulin alpha chain, putative	0.0033	0.0243	0.0738
Echinococcus multilocularis	roundabout 2	0.0015	0.0056	0.0056
Echinococcus multilocularis	lamin	0.0027	0.0184	0.0184
Echinococcus multilocularis	Tubulin beta 2C chain	0.008	0.0725	0.0725
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0179	0.0479
Trichomonas vaginalis	tubulin, putative	0.0059	0.051	0.1687
Leishmania major	protein kinase, putative	0.0013	0.0038	0.001
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0173	0.13
Echinococcus granulosus	Tubulin alpha 1 chain	0.0098	0.0912	0.244
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Echinococcus granulosus	polycomb protein SCMH1	0.0053	0.0454	0.1214
Brugia malayi	Tubulin gamma chain	0.0092	0.085	0.3406
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.021	0.2072	0.5547
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.0541	0.1449
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.0541	0.6016
Trypanosoma brucei	beta tubulin	0.0065	0.0568	0.1647
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0015	0.0063	0.0251
Loa Loa (eye worm)	tubulin beta chain	0.008	0.0725	0.1942
Trichomonas vaginalis	tubulin beta chain, putative	0.0098	0.0912	0.3112
Giardia lamblia	Gamma tubulin	0.0092	0.085	0.9169
Schistosoma mansoni	hypothetical protein	0.0019	0.01	0.0266
Trypanosoma brucei	tubulin gamma chain	0.0092	0.085	0.2563
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.0877	0.2347
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0093	0.0863	0.3458
Echinococcus granulosus	Tubulin beta 2C chain	0.008	0.0725	0.1942
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0275	0.0736
Echinococcus multilocularis	tubulin alpha chain	0.0098	0.0912	0.0912
Loa Loa (eye worm)	alpha-tubulin	0.0098	0.0912	0.244
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0288	0.0899
Entamoeba histolytica	hypothetical protein	0.0026	0.0173	0.1877
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0184	0.0492
Brugia malayi	hypothetical protein	0.0124	0.1179	0.4726
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0155	0.1497	0.4008
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0015	0.0063	0.0167
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Echinococcus granulosus	tubulin alpha chain	0.0098	0.0912	0.244
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Schistosoma mansoni	tyrosine kinase	0.0016	0.0071	0.019
Loa Loa (eye worm)	TK protein kinase	0.0039	0.0306	0.0819
Echinococcus granulosus	aryl hydrocarbon receptor	0.0013	0.0035	0.0093
Echinococcus multilocularis	tubulin beta 1 chain	0.008	0.0725	0.0725
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Echinococcus granulosus	tubulin delta chain	0.0032	0.0229	0.0612
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0288	0.0288
Schistosoma mansoni	tubulin subunit alpha	0.0098	0.0912	0.244
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0167
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0046	0.0375	0.1003
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0098	0.0912	0.244
Trichomonas vaginalis	tubulin alpha chain, putative	0.0065	0.0568	0.1893
Brugia malayi	hypothetical protein	0.0165	0.1603	0.6425
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0043	0.0349	0.3372
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0063	0.0167
Trichomonas vaginalis	tubulin alpha chain, putative	0.0033	0.0243	0.0738
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.01	0.0266
Loa Loa (eye worm)	TK/ABL protein kinase	0.0218	0.215	0.5756
Onchocerca volvulus		0.0027	0.0184	0.0637
Echinococcus granulosus	single minded 2	0.0036	0.0278	0.0744
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0014	0.0042	0.0114
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.0541	0.0541
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0053	0.0454	0.0454
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0038	0.001
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.01	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0275	0.0736
Echinococcus granulosus	lamin dm0	0.0027	0.0184	0.0492
Trypanosoma brucei	epsilon tubulin	0.0065	0.0568	0.1647
Loa Loa (eye worm)	tubulin alpha 2	0.0066	0.0586	0.1568
Brugia malayi	PAS domain containing protein	0.0049	0.041	0.1642
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0431	0.1154
Trypanosoma cruzi	tubulin delta chain	0.0032	0.0229	0.0626
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Brugia malayi	Sex muscle abnormal protein 5	0.0014	0.0042	0.017
Brugia malayi	SH2 domain containing protein	0.001	0.0002	0.0009
Loa Loa (eye worm)	beta-tubulin	0.008	0.0725	0.1942
Brugia malayi	tubulin alpha chain - mouse	0.0098	0.0912	0.3654
Echinococcus multilocularis	tubulin subunit TubB	0.0098	0.0912	0.0912
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0167	0.0428
Schistosoma mansoni	nck2/grb4	0.0014	0.0042	0.0114
Echinococcus granulosus	tubulin alpha chain	0.0098	0.0912	0.244
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0043	0.0349	0.3372
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0038	0.001
Schistosoma mansoni	tyrosine kinase	0.0046	0.0375	0.1003
Schistosoma mansoni	alpha tubulin	0.0098	0.0912	0.244
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0167	0.0341
Loa Loa (eye worm)	SRC-1	0.0046	0.0375	0.1003
Echinococcus granulosus	tyrosine kinase	0.0039	0.0306	0.0819
Echinococcus multilocularis	tubulin delta chain	0.0032	0.0229	0.0229
Mycobacterium ulcerans	cell division protein FtsZ	0.0032	0.0229	0.0793
Entamoeba histolytica	tubulin gamma chain	0.0092	0.085	0.932
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	1
Schistosoma mansoni	importin beta-1	0.0035	0.0262	0.0702
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0375	0.0375
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0375	0.0375
Brugia malayi	Variant SH3 domain containing protein	0.0014	0.0042	0.017
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0524	0.1402
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0288	0.0771
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0431	0.0431
Schistosoma mansoni	tyrosine kinase	0.001	0.0002	0.0006
Onchocerca volvulus		0.0067	0.059	0.2061
Echinococcus granulosus	geminin	0.0171	0.1668	0.4464
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0013	0.0035	0.0093
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0043	0.0349	0.1013
Loa Loa (eye worm)	tubulin beta-1 chain	0.008	0.0725	0.1942
Brugia malayi	mbt repeat family protein	0.0053	0.0454	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0877	0.2347
Brugia malayi	Tubulin beta chain	0.0032	0.0229	0.0917
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0431	0.1154
Onchocerca volvulus		0.0139	0.134	0.4695
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.0877	1
Schistosoma mansoni	tubulin subunit alpha	0.0098	0.0912	0.244
Schistosoma mansoni	protein kinase	0.0015	0.0063	0.0167
Treponema pallidum	methionine aminopeptidase (map)	0.0043	0.0349	0.2499
Brugia malayi	Tubulin beta chain	0.0033	0.0243	0.0973
Trypanosoma brucei	epsilon tubulin	0.0065	0.0568	0.1647
Plasmodium falciparum	importin beta, putative	0.0035	0.0262	0.235
Echinococcus granulosus	neuroglian	0.0012	0.0025	0.0066
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0275	0.0275
Plasmodium vivax	tubulin alpha chain, putative	0.0098	0.0912	1
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0043	0.0349	0.0349
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0375	0.1003
Trichomonas vaginalis	tubulin gamma chain, putative	0.0032	0.0229	0.0689
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0032	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0039	0.0103
Giardia lamblia	Alpha-tubulin	0.0098	0.0912	1
Loa Loa (eye worm)	mbt repeat family protein	0.0053	0.0454	0.1214
Echinococcus multilocularis	calcium dependent protein kinase	0.0015	0.0059	0.0059
Echinococcus granulosus	tubulin alpha 1C chain	0.0098	0.0912	0.244
Schistosoma mansoni	tubulin subunit alpha	0.0098	0.0912	0.244
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0046	0.0375	0.0375
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.008	0.0725	0.0725
Loa Loa (eye worm)	tubulin alpha chain	0.0098	0.0912	0.244
Echinococcus granulosus	tubulin beta 4A class IVa	0.008	0.0725	0.1942
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0046	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0114
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0176	0.047
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0167	0.0167
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0152	0.1471	0.3938
Echinococcus granulosus	tubulin alpha 3 chain	0.0098	0.0912	0.244
Echinococcus multilocularis	tubulin alpha 3 chain	0.0098	0.0912	0.0912
Trichomonas vaginalis	tubulin epsilon chain, putative	0.008	0.0725	0.2451
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0194	0.0515
Schistosoma mansoni	lamin	0.0027	0.0184	0.0492
Schistosoma mansoni	tyrosine kinase	0.0046	0.0375	0.1003
Plasmodium falciparum	alpha tubulin 2	0.0098	0.0912	1
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0043	0.0349	0.373
Brugia malayi	Cam kinase protein 1	0.0015	0.0063	0.0251
Loa Loa (eye worm)	BEN-1 protein	0.008	0.0725	0.1942
Echinococcus granulosus	tubulin alpha chain	0.0098	0.0912	0.244
Echinococcus granulosus	intermediate filament protein	0.0027	0.0184	0.0492
Trichomonas vaginalis	tubulin alpha chain, putative	0.0033	0.0243	0.0738
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0278	0.1115
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0061	0.053	0.2124
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0043	0.0349	0.2499
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0877	0.9591
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0046	0.0375	0.0375
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0275	0.0736
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0038	0.001
Brugia malayi	alpha-tubulin	0.0098	0.0912	0.3654
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0061	0.053	0.1418
Echinococcus granulosus	c src tyrosine kinase	0.0016	0.0071	0.019
Echinococcus granulosus	histone acetyltransferase MYST2	0.0061	0.053	0.1418
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0229	0.0689
Echinococcus multilocularis	tubulin subunit beta	0.008	0.0725	0.0725
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0524	0.21
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0535	0.1615
Toxoplasma gondii	beta tubulin	0.008	0.0725	0.7807
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0288	0.1155
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0016	0.0071	0.0071
Brugia malayi	SRC-1	0.0046	0.0375	0.1502
Schistosoma mansoni	single-minded	0.0049	0.041	0.1097
Brugia malayi	Probable ClpP-like protease	0.0094	0.0877	0.3515
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.021	0.2072	0.2072
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0262	0.0702
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Echinococcus granulosus	Tubulin alpha 1 chain	0.0098	0.0912	0.244
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0167	0.0671
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0098	0.0912	0.0912
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0098	0.0912	0.3112
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Schistosoma mansoni	hypothetical protein	0.0372	0.3736	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0586	0.1568
Trichomonas vaginalis	tubulin gamma chain, putative	0.008	0.0725	0.2451
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0173	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0033	0.009
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0016	0.0071	0.019
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0061	0.053	0.053
Trichomonas vaginalis	tubulin beta chain, putative	0.0098	0.0912	0.3112
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0046	0.0375	0.1003
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0039	0.0306	0.0819
Onchocerca volvulus		0.0027	0.0184	0.0637
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0033	0.0239	0.242
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.01	0.01
Onchocerca volvulus	Huntingtin homolog	0.0124	0.1179	0.4128
Echinococcus granulosus	alpha tubulin	0.0098	0.0912	0.244
Trichomonas vaginalis	ran, putative	0.0026	0.0167	0.0471
Leishmania major	protein kinase, putative	0.0013	0.0038	0.001
Onchocerca volvulus		0.0033	0.0243	0.0843
Mycobacterium leprae	cell division protein FtsZ	0.0032	0.0229	0.2304
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1179	0.3156
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0167
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0098	0.0912	0.3112
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0167
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0085	0.0778	0.2081
Trichomonas vaginalis	tubulin beta chain, putative	0.0098	0.0912	0.3112
Trypanosoma cruzi	beta tubulin, putative	0.008	0.0725	0.2228
Toxoplasma gondii	methionine aminopeptidase	0.0043	0.0349	0.3372
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2495	0.6677
Echinococcus multilocularis	GPCR, family 2	0.0019	0.01	0.01
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0167	0.1234
Entamoeba histolytica	protein kinase, putative	0.0032	0.0235	0.2564
Trichomonas vaginalis	tubulin alpha chain, putative	0.008	0.0725	0.2451
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.2853	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0167	0.0428
Echinococcus multilocularis	beta tubulin	0.008	0.0725	0.0725
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0431	0.1154
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0046	0.0378	0.1012
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0535	0.1433
Trypanosoma brucei	alpha tubulin, putative	0.0033	0.0243	0.0586
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.01	0.0399
Trichomonas vaginalis	tubulin beta chain, putative	0.0098	0.0912	0.3112
Echinococcus multilocularis	snurportin 1	0.0372	0.3736	0.3736
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0535	0.1433
Trichomonas vaginalis	tubulin, putative	0.0033	0.0243	0.0738
Schistosoma mansoni	tubulin subunit delta	0.0032	0.0229	0.0612
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0535	0.9839
Echinococcus granulosus	Tubulin beta 2C chain	0.008	0.0725	0.1942
Schistosoma mansoni	hypothetical protein	0.0052	0.0442	0.1182
Echinococcus multilocularis	tyrosine kinase	0.001	0.0002	0.0002
Echinococcus multilocularis	tubulin alpha 1C chain	0.0098	0.0912	0.0912
Toxoplasma gondii	alpha-tubulin I, putative	0.0098	0.0912	1
Echinococcus multilocularis	musashi	0.0027	0.0184	0.0184
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0431	0.1154
Trypanosoma brucei	alpha tubulin	0.0098	0.0912	0.2764
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0039	0.0306	0.0306
Schistosoma mansoni	lamin	0.0027	0.0184	0.0492
Trypanosoma cruzi	alpha tubulin, putative	0.0098	0.0912	0.2829
Brugia malayi	Pre-SET motif family protein	0.0036	0.0275	0.1102
Brugia malayi	Tubulin alpha chain	0.0032	0.0229	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0035	0.0093
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0043	0.0349	0.0934
Echinococcus granulosus	Tubulin beta 2C chain	0.008	0.0725	0.1942
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0065	0.0572	0.1907
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0066	0.0586	0.1956
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0093	0.0863	0.0863
Brugia malayi	protein-tyrosine kinase	0.0039	0.0306	0.1226
Chlamydia trachomatis	methionine aminopeptidase	0.0043	0.0349	0.373
Echinococcus granulosus	calcium dependent protein kinase	0.0015	0.0059	0.0159
Echinococcus multilocularis	tubulin alpha chain	0.0098	0.0912	0.0912
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0288	0.0771
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0032	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0327	0.0876
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0015	0.0063	0.0167
Echinococcus multilocularis	tubulin alpha 3 chain	0.0098	0.0912	0.0912
Onchocerca volvulus		0.0036	0.0275	0.0956
Loa Loa (eye worm)	hypothetical protein	0.006	0.0524	0.1402
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0063
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0043	0.0349	0.4775
Schistosoma mansoni	tubulin subunit beta	0.008	0.0725	0.1942
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0032	0.0229	0.0689
Plasmodium falciparum	tubulin delta chain, putative	0.0032	0.0229	0.1957
Echinococcus multilocularis	Tubulin beta 2C chain	0.008	0.0725	0.0725
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0145	0.1394	0.4882
Schistosoma mansoni	tubulin subunit beta	0.008	0.0725	0.1942
Brugia malayi	hypothetical protein	0.0067	0.059	0.2364
Echinococcus granulosus	growth factor receptor bound protein 2	0.0014	0.0042	0.0114
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Loa Loa (eye worm)	tubulin beta-2A chain	0.008	0.0725	0.1942
Echinococcus granulosus	tubulin alpha 3 chain	0.0098	0.0912	0.244
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0278	0.1493
Mycobacterium ulcerans	methionine aminopeptidase	0.0043	0.0349	0.2499
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.001	0.0002	0.0006
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0014	0.0042	0.0114
Echinococcus multilocularis	Tubulin beta 2C chain	0.008	0.0725	0.0725
Trichomonas vaginalis	tubulin gamma chain, putative	0.0092	0.085	0.2892
Entamoeba histolytica	tubulin alpha chain, putative	0.0098	0.0912	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0098	0.0912	0.0912
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0173	0.13
Brugia malayi	Pre-SET motif family protein	0.0251	0.2495	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0184	0.0184
Echinococcus granulosus	tyrosine protein kinase Blk	0.0039	0.0306	0.0819
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0167	0.1234
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0288	0.0771
Echinococcus granulosus	jun protein	0.0085	0.0778	0.2081
Schistosoma mansoni	tyrosine kinase	0.0211	0.208	0.5567
Schistosoma mansoni	hypothetical protein	0.0171	0.1668	0.4464
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0327	0.1313
Echinococcus multilocularis	NCK adaptor protein	0.0014	0.0042	0.0042
Onchocerca volvulus		0.0286	0.2853	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0431	0.0431
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.0173	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1603	0.429
Leishmania major	gamma-tubulin	0.0092	0.085	0.2629
Loa Loa (eye worm)	MBCTL1	0.0061	0.053	0.1418
Leishmania major	epsilon tubulin, putative	0.0065	0.0568	0.1721
Trypanosoma brucei	methionine aminopeptidase, putative	0.0043	0.0349	0.0932
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.0877	0.2347
Brugia malayi	Tubulin alpha-2 chain	0.0098	0.0912	0.3654
Trypanosoma brucei	tubulin delta chain	0.0032	0.0229	0.0541
Trypanosoma cruzi	tubulin gamma chain	0.0092	0.085	0.2629
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0098	0.0912	0.3112
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0262	0.0262
Loa Loa (eye worm)	tubulin gamma chain	0.0092	0.085	0.2274
Loa Loa (eye worm)	tubulin beta chain	0.0032	0.0229	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0033	0.009
Echinococcus granulosus	beta tubulin	0.008	0.0725	0.1942
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0043	0.0349	0.0932
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Trichomonas vaginalis	tubulin epsilon chain, putative	0.008	0.0725	0.2451
Echinococcus multilocularis	polycomb protein SCMH1	0.0053	0.0454	0.0454
Schistosoma mansoni	hypothetical protein	0.0325	0.3249	0.8698
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0039	0.0103
Schistosoma mansoni	aryl hydrocarbon receptor	0.0049	0.041	0.1097
Trypanosoma cruzi	tubulin delta chain	0.0032	0.0229	0.0626
Echinococcus granulosus	Tubulin beta 2C chain	0.008	0.0725	0.1942
Giardia lamblia	Alpha-tubulin	0.0098	0.0912	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0098	0.0912	1
Echinococcus multilocularis	beta tubulin	0.008	0.0725	0.0725
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0043	0.0349	0.3372
Trypanosoma brucei	epsilon tubulin	0.0065	0.0568	0.1647
Schistosoma mansoni	hypothetical protein	0.0019	0.01	0.0266
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0043	0.0349	0.2499
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	1
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0173	0.13
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.0454	0.1214
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0572	0.1531
Brugia malayi	Tyrosine-protein kinase abl-1	0.0129	0.123	0.493
Brugia malayi	beta-tubulin, identical	0.008	0.0725	0.2908
Toxoplasma gondii	hypothetical protein	0.0033	0.0239	0.2073
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0239	0.0932
Schistosoma mansoni	tubulin subunit beta	0.008	0.0725	0.1942
Treponema pallidum	cell division protein FtsZ	0.0032	0.0229	0.0793
Schistosoma mansoni	hypothetical protein	0.0069	0.0614	0.1643
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0039	0.0039
Brugia malayi	Protein kinase domain containing protein	0.001	0.0002	0.0009
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0043	0.0349	0.373
Giardia lamblia	Beta tubulin	0.008	0.0725	0.7499
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0184	0.0737
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0033	0.0243	0.0738
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0275	0.2499
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0524	0.21
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0235	0.063
Echinococcus granulosus	tubulin alpha chain	0.0098	0.0912	0.244
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0043	0.0349	0.0934
Entamoeba histolytica	hypothetical protein	0.0028	0.0194	0.2111
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0098	0.0912	0.0912
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0054	0.0143
Brugia malayi	mbt repeat family protein	0.0053	0.0454	0.1818
Brugia malayi	Methionine aminopeptidase protein type I	0.0043	0.0349	0.1398
Echinococcus multilocularis	tyrosine protein kinase shark	0.001	0.0002	0.0002
Brugia malayi	intermediate filament protein	0.0027	0.0184	0.0737
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0043	0.0349	0.0349
Plasmodium falciparum	tubulin beta chain	0.008	0.0725	0.7807
Plasmodium falciparum	alpha tubulin 1	0.0098	0.0912	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0288	0.3145
Echinococcus granulosus	beta tubulin	0.008	0.0725	0.1942
Trypanosoma brucei	beta tubulin	0.008	0.0725	0.2158
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0184	0.0492
Echinococcus granulosus	tyrosine protein kinase Srms	0.001	0.0002	0.0006
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0043	0.0349	0.3372
Schistosoma mansoni	growth factor receptor-bound protein	0.0014	0.0042	0.0114
Trypanosoma brucei	zeta tubulin	0.0313	0.3134	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0032	0.0085
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0288	0.0288
Schistosoma mansoni	hypothetical protein	0.0019	0.01	0.0266
Loa Loa (eye worm)	tubulin alpha 2	0.0033	0.0246	0.0659
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0288	0.0818
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Entamoeba histolytica	Ran family GTPase	0.0026	0.0167	0.1815
Brugia malayi	hypoxia-induced factor 1	0.0152	0.1471	0.5897
Brugia malayi	Cell division protein ftsZ	0.0032	0.0229	0.0917
Brugia malayi	tubulin alpha-2 chain	0.0098	0.0912	0.3654
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0306	0.0306
Schistosoma mansoni	tyrosine kinase	0.0016	0.0071	0.019
Brugia malayi	Tubulin beta-1 chain	0.008	0.0725	0.2908
Plasmodium vivax	tubulin epsilon chain, putative	0.0065	0.0568	0.5957
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0096	0.0892	0.0892
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0535	0.515
Giardia lamblia	Delta tubulin	0.0032	0.0229	0.0825
Echinococcus multilocularis	peroxisome assembly protein 26	0.0098	0.0912	0.0912
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0043	0.0349	0.0932
Toxoplasma gondii	beta-tubulin, putative	0.008	0.0725	0.7807
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	1
Schistosoma mansoni	tyrosine kinase	0.001	0.0002	0.0006
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Trypanosoma brucei	beta tubulin	0.008	0.0725	0.2158
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0036	0.0277	0.0277
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0032	0.0229	0.1957
Trichomonas vaginalis	tubulin beta chain, putative	0.0098	0.0912	0.3112
Echinococcus granulosus	snurportin 1	0.0372	0.3736	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0218	0.215	0.5756
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0066	0.0586	0.1568
Echinococcus multilocularis	geminin	0.0171	0.1668	0.1668
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0061	0.053	0.1418
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Brugia malayi	Protein kinase domain containing protein	0.001	0.0002	0.0009
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0043	0.0349	0.1013
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0288	0.0899
Brugia malayi	Protein kinase domain containing protein	0.001	0.0002	0.0009
Schistosoma mansoni	hypothetical protein	0.0171	0.1668	0.4464
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0375	0.1003
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0877	0.9591
Echinococcus multilocularis	neuroglian	0.0012	0.0025	0.0025
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.01	0.0399
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0032	0.0229	0.0689
Brugia malayi	Tyrosine-protein kinase abl-1	0.0096	0.0892	0.3577
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0184	0.0492
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Echinococcus multilocularis	tubulin alpha chain	0.0098	0.0912	0.0912
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0275	0.0275
Brugia malayi	Tubulin alpha-2 chain	0.0098	0.0912	0.3654
Echinococcus multilocularis	tubulin alpha	0.0065	0.0568	0.0568
Plasmodium vivax	delta tubulin, putative	0.0032	0.0229	0.1957
Echinococcus multilocularis	Tubulin beta 2C chain	0.008	0.0725	0.0725
Onchocerca volvulus		0.0013	0.0035	0.0114
Trichomonas vaginalis	tubulin beta chain, putative	0.0098	0.0912	0.3112
Onchocerca volvulus		0.0053	0.0454	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0063	0.0167
Schistosoma mansoni	serine/threonine protein kinase	0.0009	0.0001	0.0001
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0046	0.0375	0.0375
Echinococcus multilocularis	hypothetical protein	0.0098	0.0912	0.0912
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0194	0.0515
Brugia malayi	Tubulin alpha chain	0.0098	0.0912	0.3654
Plasmodium vivax	tubulin alpha chain, putative	0.0098	0.0912	1
Brugia malayi	Variant SH3 domain containing protein	0.0014	0.0042	0.017
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0535	0.0535
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.0877	0.0877
Schistosoma mansoni	protein kinase	0.0015	0.0063	0.0167
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0063
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Echinococcus granulosus	Tubulin beta 2C chain	0.008	0.0725	0.1942
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0184	0.0492
Echinococcus granulosus	tubulin subunit TubB	0.0098	0.0912	0.244
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0275	0.0736
Echinococcus granulosus	roundabout 2	0.0015	0.0056	0.0151
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Echinococcus multilocularis	Tubulin beta 2C chain	0.008	0.0725	0.0725
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.0877	0.9591
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.0541	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0098	0.0912	1
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0043	0.0349	0.3372
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0262	0.0702
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Schistosoma mansoni	nephrin	0.0012	0.0025	0.0066
Entamoeba histolytica	protein kinase, putative	0.0015	0.0063	0.0663
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0288	0.0771
Echinococcus granulosus	tubulin alpha 1C chain	0.0098	0.0912	0.244
Echinococcus multilocularis	tubulin epsilon chain	0.0065	0.0568	0.0568
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.0541	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.01	0.01
Schistosoma mansoni	adapter molecule crk	0.0014	0.0042	0.0114
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0431	0.1728
Plasmodium vivax	tubulin gamma chain, putative	0.0092	0.085	0.9271
Loa Loa (eye worm)	tubulin alpha 2	0.0066	0.0586	0.1568
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0013	0.0035	0.0035
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	1
Trichomonas vaginalis	CAMK family protein kinase	0.0015	0.0063	0.0099
Trypanosoma cruzi	zeta tubulin, putative	0.0313	0.3134	1
Schistosoma mansoni	ran	0.0026	0.0167	0.0448
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0288	0.0818
Trypanosoma brucei	zeta tubulin, putative	0.0313	0.3134	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0092	0.085	0.085
Echinococcus multilocularis	tubulin alpha chain	0.0098	0.0912	0.0912
Echinococcus granulosus	tubulin alpha	0.0065	0.0568	0.1521
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0092	0.085	0.2274
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0043	0.0349	0.1013
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0046	0.0375	0.0375
Echinococcus granulosus	SAM and MBT domain containing protein	0.0053	0.0454	0.1214
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0006
Brugia malayi	SH2 domain containing protein	0.001	0.0002	0.0009
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0167	0.1234
Echinococcus granulosus	lamin	0.0027	0.0184	0.0492
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0194	0.0566
Echinococcus granulosus	tubulin alpha chain	0.0098	0.0912	0.244
Giardia lamblia	Beta tubulin	0.008	0.0725	0.7499
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0375	0.1003
Trypanosoma brucei	alpha tubulin	0.0098	0.0912	0.2764
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0229	0.0689
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0012	0.0032	0.0085
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0065	0.0572	0.1531
Plasmodium vivax	tubulin beta chain, putative	0.008	0.0725	0.7807
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0093	0.0863	0.2309
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0863	0.2309
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0912	0.244
Trypanosoma cruzi	epsilon tubulin, putative	0.0065	0.0568	0.1721
Schistosoma mansoni	growth factor receptor-bound protein	0.0014	0.0042	0.0114
Schistosoma mansoni	ran	0.0026	0.0167	0.0448
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0288	0.0771
Trypanosoma cruzi	epsilon tubulin, putative	0.0065	0.0568	0.1721
Echinococcus granulosus	L aminoadipate semialdehyde	0.0093	0.0863	0.2309
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0288	0.0288
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0043	0.0349	0.0934
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0173	0.13
Trypanosoma brucei	beta tubulin	0.008	0.0725	0.2158
Brugia malayi	bZIP transcription factor family protein	0.0085	0.0778	0.3117
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0375	0.0375
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0288	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0288	0.0771
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0431	0.1154
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0032	0.0229	0.0793
Echinococcus multilocularis	c src tyrosine kinase	0.0016	0.0071	0.0071
Entamoeba histolytica	protein kinase, putative	0.0015	0.0063	0.0663
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0262	0.065
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0015	0.0063	0.0063
Plasmodium falciparum	tubulin epsilon chain, putative	0.0065	0.0568	0.5957
Brugia malayi	Importin beta-1 subunit	0.0035	0.0262	0.1051
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.001	0.0002	0.0002
Trypanosoma brucei	beta tubulin	0.008	0.0725	0.2158
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0013	0.0035	0.0093
Schistosoma mansoni	hypothetical protein	0.0019	0.01	0.0266
Leishmania major	GTP-binding protein, putative	0.0026	0.0167	0.0428
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Giardia lamblia	Beta tubulin	0.008	0.0725	0.7499
Loa Loa (eye worm)	alpha-tubulin	0.0098	0.0912	0.244
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0262	0.235
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0278	0.0278
Echinococcus multilocularis	tubulin alpha chain	0.0098	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0754	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0753	0.2016
Onchocerca volvulus	Huntingtin homolog	0.0124	0.1179	0.4128
Trypanosoma brucei	alpha tubulin	0.0098	0.0912	0.2764
Leishmania major	delta tubulin, putative	0.0032	0.0229	0.0626
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0194	0.0566
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0288	0.1624
Toxoplasma gondii	beta-1 tubulin, putative	0.008	0.0725	0.7807
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0167	0.0448
Schistosoma mansoni	alpha tubulin	0.0098	0.0912	0.244
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.01	0.0266
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0877	0.9591
Brugia malayi	hypothetical protein	0.001	0.0002	0.0009
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0038	0.001
Echinococcus granulosus	tyrosine protein kinase shark	0.001	0.0002	0.0006
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0053	0.0454	0.1214
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Leishmania major	zeta tubulin, putative	0.0313	0.3134	1
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.0454	0.1214
Giardia lamblia	Epsilon tubulin	0.0032	0.0229	0.0825
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0014	0.0042	0.0114
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Schistosoma mansoni	tubulin subunit epsilon	0.0065	0.0568	0.1521
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.1497	0.6003
Brugia malayi	Protein kinase domain containing protein	0.001	0.0002	0.0009
Trichomonas vaginalis	tubulin, putative	0.0033	0.0243	0.0738
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0046	0.0375	0.1003
Schistosoma mansoni	tubulin subunit beta	0.0032	0.0229	0.0612
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0046	0.0375	0.1003
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0013	0.0035	0.0035
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0065	0.0568	0.5957
Echinococcus multilocularis	jun protein	0.0085	0.0778	0.0778
Echinococcus granulosus	tubulin epsilon chain	0.0065	0.0568	0.1521
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0262	0.235
Schistosoma mansoni	hypothetical protein	0.0041	0.0327	0.0876
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0061	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0454	0.1214
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0218	0.215	0.215
Loa Loa (eye worm)	tubulin beta-4 chain	0.008	0.0725	0.1942
Leishmania major	protein kinase, putative	0.0015	0.0063	0.009
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Echinococcus granulosus	tubulin beta 1 chain	0.008	0.0725	0.1942
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0015	0.0063	0.0167
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0085	0.0778	0.0778
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0033	0.0239	0.2073
Schistosoma mansoni	protein kinase	0.0015	0.0063	0.0167
Leishmania major	beta tubulin	0.008	0.0725	0.2228
Trichomonas vaginalis	tubulin gamma chain, putative	0.0065	0.0568	0.1893
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Trypanosoma brucei	alpha tubulin	0.0098	0.0912	0.2764
Brugia malayi	RNA, U transporter 1	0.0099	0.0924	0.3704
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0173	0.1641
Echinococcus granulosus	GPCR family 2	0.0019	0.01	0.0266
Echinococcus granulosus	peroxisome assembly protein 26	0.0098	0.0912	0.244
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0262	0.065
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0167	0.0448
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0275	0.0736
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0535	0.1433
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0151
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0098	0.0912	0.0912
Echinococcus granulosus	NCK adaptor protein	0.0014	0.0042	0.0114
Onchocerca volvulus		0.0093	0.0863	0.3018
Onchocerca volvulus		0.0036	0.0278	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1179	0.3156
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0535	0.515
Loa Loa (eye worm)	BEN-1 protein	0.008	0.0725	0.1942
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0046	0.0375	0.0375
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0032	0.0229	0.1515
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0016	0.0071	0.019
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0173	0.036
Leishmania major	alpha tubulin	0.0098	0.0912	0.2829
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0151
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.3736	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0535	0.515
Schistosoma mansoni	tubulin subunit beta	0.008	0.0725	0.1942
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.0725	0.2451
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0053	0.0454	0.1583
Echinococcus granulosus	Tubulin alpha 1 chain	0.0098	0.0912	0.244
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0431	0.1154
Schistosoma mansoni	tubulin subunit beta	0.008	0.0725	0.1942
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0288	0.0735
Entamoeba histolytica	tubulin family protein	0.008	0.0725	0.7953
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0039	0.0306	0.0306
Echinococcus granulosus	twitchin	0.0012	0.0028	0.0075
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0261	0.0699
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0535	0.557
Plasmodium vivax	SET domain protein, putative	0.0036	0.0275	0.2499
Schistosoma mansoni	jun-related protein	0.0069	0.0614	0.1643
Echinococcus granulosus	tyrosine protein kinase HCK	0.0032	0.0235	0.063
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0176	0.0704
Trichomonas vaginalis	tubulin, putative	0.008	0.0725	0.2451
Schistosoma mansoni	tubulin subunit beta	0.008	0.0725	0.1942
Loa Loa (eye worm)	tubulin alpha chain	0.0098	0.0912	0.244
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0002	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0019	0.01	0.0266
Schistosoma mansoni	tubulin subunit gamma	0.0092	0.085	0.2274
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0054	0.0215
Echinococcus granulosus	tubulin subunit beta	0.008	0.0725	0.1942
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.0243	0.0738
Entamoeba histolytica	tubulin family protein	0.008	0.0725	0.7953
Schistosoma mansoni	alpha tubulin	0.0098	0.0912	0.244
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0275	0.0736
Trypanosoma cruzi	zeta tubulin, putative	0.0313	0.3134	1
Toxoplasma gondii	methionine aminopeptidase	0.0043	0.0349	0.3372
Loa Loa (eye worm)	hypothetical protein	0.0061	0.053	0.1418
Plasmodium falciparum	tubulin gamma chain	0.0092	0.085	0.9271
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0014	0.0042	0.0042
Echinococcus granulosus	tyrosine kinase	0.001	0.0002	0.0006
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0043	0.0349	0.4775
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0239	0.2073
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0194	0.0566

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.3078 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3535 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	67.4555 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1370370

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1219086