Detailed information for compound 1242272

Basic information

Technical information
  • TDR Targets ID: 1242272
  • Name: ChemDivAM_000167
  • MW: 499.343 | Formula: C25H20Cl2N2O5
  • H donors: 0 H acceptors: 3 LogP: 4.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)C(=O)OCCn1c(=O)c2cccc3c2c(c1=O)ccc3N1CCOCC1
  • InChi: 1S/C25H20Cl2N2O5/c26-15-4-5-16(20(27)14-15)25(32)34-13-10-29-23(30)18-3-1-2-17-21(28-8-11-33-12-9-28)7-6-19(22(17)18)24(29)31/h1-7,14H,8-13H2
  • InChiKey: RPTBEJCGKVGUHU-UHFFFAOYSA-N  

Network

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Synonyms

  • MLS000722249
  • SMR000235882
  • ChemDiv1_000490

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens troponin I type 3 (cardiac) Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens kelch-like ECH-associated protein 1 No references
Homo sapiens troponin T type 2 (cardiac) Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens troponin C type 1 (slow) Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Human herpesvirus 8 ORF 73 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Mycobacterium ulcerans UDP-galactopyranose mutase Glf Get druggable targets OG5_139595 All targets in OG5_139595
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Troponin I homolog Get druggable targets OG5_132708 All targets in OG5_132708
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Troponin family protein Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) troponin Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine non-variant cyst protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus granulosus coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Troponin I 4, putative Get druggable targets OG5_132708 All targets in OG5_132708
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni troponin t invertebrate Get druggable targets OG5_129858 All targets in OG5_129858
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 Get druggable targets OG5_129858 All targets in OG5_129858
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Involucrin, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Kelch-like ECH-associated protein 1, putative Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum IPR001978,Troponin,domain-containing Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K10456 kelch-like protein 19, putative Get druggable targets OG5_134673 All targets in OG5_134673
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Troponin T, skeletal muscle, putative Get druggable targets OG5_129858 All targets in OG5_129858
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_132708 All targets in OG5_132708
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Neurogenic locus notch protein homolog precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni notch Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134673 All targets in OG5_134673
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis Kelch repeat type 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus oncosphere protein Tso22e Get druggable targets OG5_129858 All targets in OG5_129858
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica CXXC-rich protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia High cysteine membrane protein Group 1 Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Brugia malayi Kelch motif family protein kelch-like ECH-associated protein 1 624 aa 565 aa 31.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum centrin-3 troponin C type 1 (slow) 161 aa 148 aa 33.1 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus jumonji domain containing 1A 0.0022 0.0121 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0463 0.0463
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.3014 0.3556
Mycobacterium ulcerans beta-lactamase 0.004 0.0349 0.0266
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0062 0.0062
Echinococcus granulosus oncosphere protein Tso22e 0.016 0.1822 0.1822
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0089 0.0156
Schistosoma mansoni hypothetical protein 0.0041 0.036 0.036
Brugia malayi Bromodomain containing protein 0.0092 0.099 0.154
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0542
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0089 0.0138
Echinococcus granulosus troponin i 0.0129 0.144 0.144
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0391 0.1127
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0681 1
Toxoplasma gondii ABC1 family protein 0.004 0.0349 0.5123
Schistosoma mansoni troponin I 0.0129 0.144 0.144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0089 0.0089
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0099 0.1077 0.1077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0559 0.0559
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.000000000066352 0.00000000097446
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0661 0.0661
Brugia malayi mbt repeat family protein 0.0058 0.0563 0.0875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0264
Loa Loa (eye worm) jmjC domain-containing protein 0.0085 0.0906 0.1408
Onchocerca volvulus 0.0058 0.0563 0.0859
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0198 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0067 0.0681 1
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.1257 0.1257
Onchocerca volvulus 0.0099 0.1077 0.166
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0062 0.0096
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.022 0.2562 0.2562
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.062 0.1457
Echinococcus multilocularis chromobox protein 1 0.0078 0.0811 0.0811
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.062 0.062
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0011 0.0161
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0011 0.0161
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0198 0.0392
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0011 0.00000000089667
Mycobacterium tuberculosis Conserved protein 0.004 0.0349 0.0316
Echinococcus granulosus peregrin 0.007 0.0716 0.0716
Loa Loa (eye worm) runx1 0.0067 0.0679 0.1056
Leishmania major hypothetical protein, conserved 0.0027 0.0185 0.0358
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0019 0.0093 0.1224
Echinococcus multilocularis snurportin 1 0.0372 0.4426 0.4426
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0022 0.0124 0.1828
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0283 0.0643
Brugia malayi CXXC zinc finger family protein 0.0032 0.0246 0.0383
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0089 0.0089
Echinococcus granulosus phd:f box containing protein 0.0022 0.0121 0.0121
Loa Loa (eye worm) PHD-finger family protein 0.0067 0.0681 0.1059
Loa Loa (eye worm) hypothetical protein 0.0144 0.1631 0.2536
Loa Loa (eye worm) troponin T 0.0076 0.0795 0.1236
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0062 0.0062
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0198 0.0082
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0207 0.0322
Brugia malayi mbt repeat family protein 0.0058 0.0563 0.0875
Schistosoma mansoni hypothetical protein 0.0205 0.2371 0.2371
Schistosoma mansoni jumonji/arid domain-containing protein 0.0085 0.0906 0.0906
Schistosoma mansoni hypothetical protein 0.0022 0.0124 0.0124
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0131 0.0515
Schistosoma mansoni hypothetical protein 0.0372 0.4426 0.4426
Brugia malayi hypothetical protein 0.0076 0.0795 0.1236
Plasmodium falciparum importin beta, putative 0.0035 0.0283 0.4149
Echinococcus multilocularis Protein lozenge 0.0067 0.0679 0.0679
Echinococcus multilocularis phd:f box containing protein 0.0022 0.0121 0.0121
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0563 0.0563
Trypanosoma brucei protein kinase, putative 0.0062 0.062 0.1491
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0349 0.0349
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0563 0.0859
Onchocerca volvulus Huntingtin homolog 0.0146 0.1656 0.2561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0052 0.0122
Loa Loa (eye worm) troponin 0.0076 0.0795 0.1236
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0089 0.0138
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0011 0.0161
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0198 0.2909
Echinococcus multilocularis jumonji domain containing 1A 0.0022 0.0121 0.0121
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0108 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0595 0.0924
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0131 0.0356
Brugia malayi RNA, U transporter 1 0.0099 0.1072 0.1667
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0131 0.0131
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0089 0.0089
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0811 0.2375
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.01 0.0264
Schistosoma mansoni chromobox protein 0.0013 0.0011 0.0011
Schistosoma mansoni troponin I 0.0129 0.144 0.144
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0289 0.0449
Schistosoma mansoni hypothetical protein 0.0067 0.0681 0.0681
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0264
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0349 0.0316
Loa Loa (eye worm) hypothetical protein 0.0085 0.0905 0.1406
Loa Loa (eye worm) jmjC domain-containing protein 0.0139 0.1561 0.2427
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6722 0.6722
Leishmania major hypothetical protein, conserved 0.004 0.0349 0.0773
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0043 0.0126
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0349 0.0316
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0062 0.0062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1818 0.4504
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0043 0.004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.062 0.1491
Brugia malayi PHD-finger family protein 0.0026 0.0175 0.0272
Schistosoma mansoni hypothetical protein 0.0018 0.0082 0.0082
Brugia malayi hypothetical protein 0.0043 0.0389 0.0604
Brugia malayi Troponin T 0.0076 0.0795 0.1236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0389 0.0389
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0089 0.0156
Echinococcus multilocularis geminin 0.0205 0.2371 0.2371
Loa Loa (eye worm) hypothetical protein 0.0067 0.0681 0.1059
Brugia malayi PHD-finger family protein 0.0067 0.0681 0.1059
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0131 0.0356
Echinococcus granulosus bloom syndrome protein 0.0029 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0066 0.0661 0.1027
Loa Loa (eye worm) hypothetical protein 0.0146 0.1656 0.2574
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0022 0.0121 0.0121
Onchocerca volvulus 0.004 0.0349 0.0526
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0022 0.0121 0.0237
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0022 0.0124 0.0245
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0202 0.0566
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0835 0.2031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.01 0.0264
Echinococcus multilocularis GPCR, family 2 0.0019 0.0089 0.0089
Trypanosoma cruzi polo-like protein kinase, putative 0.0218 0.2539 0.6319
Brugia malayi hypothetical protein 0.0535 0.6432 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0148 0.2179
Brugia malayi beta-lactamase family protein 0.004 0.0349 0.0542
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0431 0.1248
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.022 0.2562 0.2562
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.0659
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.338 0.9997
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0542
Brugia malayi Bromodomain containing protein 0.0046 0.0423 0.0658
Onchocerca volvulus 0.0287 0.3381 0.5248
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0661 0.1027
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0688 0.8314 1
Trypanosoma brucei polo-like protein kinase 0.0218 0.2539 0.6319
Brugia malayi hypothetical protein 0.0146 0.1656 0.2574
Schistosoma mansoni ap endonuclease 0.0022 0.0131 0.0131
Trypanosoma cruzi ISWI complex protein 0.0018 0.0082 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0048
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0089 0.0156
Schistosoma mansoni ap endonuclease 0.0022 0.0131 0.0131
Echinococcus multilocularis lysine specific demethylase 6a 0.0022 0.0121 0.0121
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0011 0.0161
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0306 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.062 0.1807
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0349 0.0809
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0198 0.2794
Schistosoma mansoni troponin t invertebrate 0.016 0.1822 0.1822
Loa Loa (eye worm) RecQ helicase 0.0029 0.0207 0.0322
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0349 0.0316
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0835 0.3258
Schistosoma mansoni tsg101-related 0.007 0.0714 0.0714
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0559 0.0559
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0349 0.0316
Mycobacterium tuberculosis Conserved protein 0.004 0.0349 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0048
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3366 0.3366
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0542
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4426 0.6881
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.00000000017828
Schistosoma mansoni hypothetical protein 0.0058 0.0571 0.0571
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0121 0.0188
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0661 0.0661
Brugia malayi jmjC domain containing protein 0.0085 0.0906 0.1408
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0089 0.0138
Onchocerca volvulus 0.0013 0.0011 0.000000028918
Schistosoma mansoni hypothetical protein 0.0129 0.144 0.144
Loa Loa (eye worm) MBCTL1 0.0066 0.0661 0.1027
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0011 0.0011
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0422 0.0422
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0835 0.2
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0131 0.1921
Schistosoma mansoni protein phosphatase 2C 0.0022 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0535 0.6432 1
Echinococcus multilocularis Chromo domain 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0542
Echinococcus granulosus jumonji domain containing protein 0.0094 0.1005 0.1005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0349 0.0542
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0202 0.0566
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0059 0.0141
Brugia malayi AF-10 protein 0.0022 0.0124 0.0194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0089 0.0138
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Brugia malayi PHD-finger family protein 0.0032 0.0247 0.0383
Brugia malayi Pre-SET motif family protein 0.0037 0.0306 0.0476
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.062 0.1491
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.056
Loa Loa (eye worm) hypothetical protein 0.0055 0.0534 0.083
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.062 0.062
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0283 0.4149
Onchocerca volvulus Serine\/threonine kinase homolog 0.0218 0.2539 0.3938
Onchocerca volvulus 0.0049 0.0463 0.0704
Schistosoma mansoni phd/f-box containing protein 0.0022 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0081 0.0855 0.0855
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0835 0.1298
Loa Loa (eye worm) hypothetical protein 0.0049 0.0459 0.0714
Brugia malayi serine/threonine-protein kinase plk-2 0.0218 0.2539 0.3948
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0349 0.0316
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0022 0.0124 0.0245
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.2702 0.2702
Schistosoma mansoni zinc finger protein 0.0018 0.0082 0.0082
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.0022 0.0121 0.0188
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0198 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0337 0.4003 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0563 0.0563
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0431 0.1248
Schistosoma mansoni jumonji/arid domain-containing protein 0.0085 0.0906 0.0906
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0121 0.0188
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0011 0.0161
Plasmodium vivax JmjC domain containing protein 0.0022 0.0121 0.1645
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0089 0.0089
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0835 0.0835
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0563 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0559 0.0559
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0164 0.2414
Plasmodium falciparum JmjC domain-containing protein, putative 0.0022 0.0121 0.1779
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0349 0.0316
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0563 0.0563
Echinococcus granulosus lysine specific demethylase 6a 0.0022 0.0121 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.00000000017828
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0131 0.0203
Leishmania major importin beta-1 subunit, putative 0.0028 0.0202 0.0401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0131 0.0261
Echinococcus granulosus chromobox protein 1 0.0078 0.0811 0.0811
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0542
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0571 0.0887
Plasmodium falciparum phd finger protein, putative 0.0067 0.0681 1
Giardia lamblia PHD finger protein 15 0.0067 0.0681 0.2681
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0022 0.0121 0.1779
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0089 0.1164
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.036 0.056
Plasmodium vivax importin-beta 2, putative 0.0035 0.0283 0.4054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.00000000017828
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.2039 0.2371
Mycobacterium leprae conserved hypothetical protein 0.004 0.0349 0.0186
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0131 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.0389 0.1494
Loa Loa (eye worm) hypothetical protein 0.006 0.0595 0.0924
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0388 0.0388
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0198 0.043
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0211 0.0211
Toxoplasma gondii exonuclease III APE 0.0022 0.0131 0.1921
Loa Loa (eye worm) beta-lactamase 0.004 0.0349 0.0542
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0218 0.2539 0.3948
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0563 0.0563
Echinococcus granulosus Chromo domain 0.0013 0.0011 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0131 0.0203
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0438 0.1033
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.338 0.9997
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0218 0.2539 0.2539
Schistosoma mansoni kinase 0.0111 0.1222 0.1222
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0198 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0000000002376
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.338 0.9997
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1627 0.253
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.062 0.1807
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.1257 0.1257
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0099 0.1077 0.1674
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1187 0.349
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0185 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0349 0.0809
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0133 0.0133
Echinococcus multilocularis PHD finger protein rhinoceros 0.0067 0.0681 0.0681
Onchocerca volvulus Huntingtin homolog 0.0146 0.1656 0.2561
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.338 0.9997
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0835 0.1298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0131 0.0261
Entamoeba histolytica hypothetical protein 0.0014 0.0027 0.0064
Schistosoma mansoni hypothetical protein 0.0043 0.0389 0.0389
Brugia malayi Heterochromatin protein 1 0.0078 0.0811 0.1261
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0011 0.0161
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0349 0.1003
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0198 0.2909
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0211 0.0211
Schistosoma mansoni cpg binding protein 0.0036 0.0297 0.0297
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0198 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1627 0.253
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0148 0.2051
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0563 0.0875
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0349 0.0316
Schistosoma mansoni zinc finger protein 0.0025 0.0167 0.0167
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0661 0.0661
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0349 0.0542
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0011 0.0017
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0022 0.0121 0.1779
Schistosoma mansoni bromodomain containing protein 0.0078 0.0816 0.0816
Schistosoma mansoni chromobox protein 0.0078 0.0811 0.0811
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.338 0.9997
Echinococcus granulosus zinc finger protein 0.0025 0.0167 0.0167
Mycobacterium ulcerans hypothetical protein 0.004 0.0349 0.0266
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0011 0.0017
Brugia malayi Protein cec-1. 0.0013 0.0011 0.0017
Toxoplasma gondii hypothetical protein 0.0054 0.0523 0.7687
Entamoeba histolytica hypothetical protein 0.0028 0.0202 0.0754
Echinococcus granulosus kelch ECH associated protein 1 0.0114 0.1257 0.1257
Schistosoma mansoni chromobox protein 0.0013 0.0011 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0763 0.0763
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0349 0.0266
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0067 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0053 0.051 0.0793
Brugia malayi SET domain containing protein 0.0015 0.0036 0.0056
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6722 0.6722
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.062 0.0963
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0089 0.1306
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3381 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0349 0.1003
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0011 0.0011
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0121 0.0188
Echinococcus granulosus L aminoadipate semialdehyde 0.0099 0.1077 0.1077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0264
Toxoplasma gondii PHD-finger domain-containing protein 0.0067 0.0681 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0438 0.1033
Onchocerca volvulus 0.0058 0.0571 0.0872
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0108 0.0108
Leishmania major mitochondrial DNA polymerase beta 0.0337 0.4003 1
Schistosoma mansoni troponin I 0.0129 0.144 0.144
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0422 0.0422
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0563 0.0563
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0349 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0234 0.0662
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.0887 0.0887
Onchocerca volvulus 0.0032 0.0246 0.0367
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.062 0.1491
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0131 0.0474
Echinococcus granulosus PHD finger protein rhinoceros 0.0067 0.0681 0.0681
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0185 0.0396
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0198 1
Echinococcus granulosus chromobox protein 2 0.0013 0.0011 0.0011
Echinococcus multilocularis microtubule associated protein 2 0.0825 1 1
Entamoeba histolytica hypothetical protein 0.0014 0.0027 0.0064
Brugia malayi jmjC domain containing protein 0.022 0.2562 0.3982
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0286 0.3366 0.5233
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.062 0.1457
Entamoeba histolytica hypothetical protein 0.0043 0.0389 0.1494
Schistosoma mansoni survival motor neuron protein 0.0058 0.0571 0.0571
Echinococcus granulosus GPCR family 2 0.0019 0.0089 0.0089
Schistosoma mansoni tsg101-related 0.007 0.0714 0.0714
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0389 0.0389
Echinococcus multilocularis Kelch repeat type 1 0.0114 0.1261 0.1261
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0349 0.0809
Loa Loa (eye worm) hypothetical protein 0.0129 0.144 0.2239
Brugia malayi hypothetical protein 0.0286 0.3366 0.5233
Echinococcus multilocularis jumonji domain containing protein 0.0094 0.1005 0.1005
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0234 0.0662
Loa Loa (eye worm) hypothetical protein 0.0146 0.1656 0.2574
Echinococcus multilocularis tumor protein p63 0.0377 0.4496 0.4496
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6722 0.6722
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1818 0.4482
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0131 0.1789
Brugia malayi Troponin T 0.0076 0.0795 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Schistosoma mansoni hypothetical protein 0.0205 0.2371 0.2371
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3366 0.3366
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0218 0.2539 0.2539
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0565 0.1354
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.062 0.1491
Mycobacterium tuberculosis Conserved protein 0.004 0.0349 0.0316
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0835 0.0835
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0283 0.0283
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0131 0.0261
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0811 0.1261
Loa Loa (eye worm) hypothetical protein 0.0058 0.0563 0.0875
Onchocerca volvulus Troponin I homolog 0.0129 0.144 0.2226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0089 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0763 0.0763
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.1257 0.1257
Echinococcus multilocularis chromobox protein 2 0.0013 0.0011 0.0011
Loa Loa (eye worm) troponin I 0.0129 0.144 0.2239
Mycobacterium leprae Probable lipase LipE 0.004 0.0349 0.0186
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0389 0.0389
Mycobacterium ulcerans lipase LipD 0.004 0.0349 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.0439
Brugia malayi Troponin family protein 0.0129 0.144 0.2239
Echinococcus granulosus tumor protein p63 0.0377 0.4496 0.4496
Onchocerca volvulus 0.0055 0.0534 0.0814
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0117 0.0181
Brugia malayi isocitrate dehydrogenase 0.0019 0.0089 0.0138
Echinococcus granulosus JmjC domain containing protein 4 0.0022 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0531 0.6383 0.9923
Loa Loa (eye worm) hypothetical protein 0.0057 0.0559 0.087
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.2702 0.2702
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0025 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0019 0.0089 0.0089
Entamoeba histolytica hypothetical protein 0.0043 0.0389 0.1494
Echinococcus multilocularis peregrin 0.007 0.0716 0.0716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0306 0.0306
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.062 0.2441
Onchocerca volvulus 0.0531 0.6383 0.9923
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.062 0.1491
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0559 0.0559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0438 0.1033
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2292 0.6769
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0161 0.025
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0108 0.0108
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0283 0.0643
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.2539 0.2539
Schistosoma mansoni microtubule-associated protein tau 0.0825 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0207 0.0583
Onchocerca volvulus 0.0034 0.0275 0.0411
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0011 0.0011
Loa Loa (eye worm) helicase 0.0013 0.0011 0.0017
Schistosoma mansoni hypothetical protein 0.0019 0.0089 0.0089
Entamoeba histolytica serine/threonine protein kinase, putative 0.0218 0.2539 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0202 0.0566
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.016 0.1822 0.1822
Loa Loa (eye worm) hypothetical protein 0.0129 0.144 0.2239
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.1818 0.4504
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1187 0.349
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.062 0.062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0264
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0264
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0287 0.338 0.5254
Echinococcus multilocularis zinc finger protein 0.0025 0.0167 0.0167
Plasmodium vivax hypothetical protein, conserved 0.004 0.0349 0.5044
Brugia malayi Pre-SET motif family protein 0.0252 0.2954 0.4592
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0000000002376
Schistosoma mansoni cpg binding protein 0.0032 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0211 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0306 0.4497
Onchocerca volvulus 0.004 0.0349 0.0526
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0391 0.0591
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0438 0.1033
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0207 0.0583
Schistosoma mansoni hypothetical protein 0.0019 0.0089 0.0089
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0000000002376
Leishmania major hypothetical protein, conserved 0.0018 0.0082 0.0098
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0043 0.0095
Entamoeba histolytica hypothetical protein 0.0014 0.0027 0.0064
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0089 0.0089
Trypanosoma brucei ISWI complex protein 0.0018 0.0082 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.062 0.1807
Entamoeba histolytica hypothetical protein 0.0043 0.0389 0.1494
Brugia malayi beta-lactamase family protein 0.004 0.0349 0.0542
Echinococcus multilocularis cpg binding protein 0.0036 0.0297 0.0297
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0011 0.0017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0089 0.0089
Schistosoma mansoni jumonji domain containing protein 0.0022 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0542
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0388 0.0388
Brugia malayi MH2 domain containing protein 0.0144 0.1627 0.253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0019 0.0089 0.0089
Echinococcus granulosus cpg binding protein 0.0036 0.0297 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Brugia malayi hypothetical protein 0.0013 0.0011 0.0017
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0076 0.0795 0.1221
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 0.4003 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0131 0.0222
Giardia lamblia Kinase, PLK 0.0218 0.2539 1
Echinococcus granulosus snurportin 1 0.0372 0.4426 0.4426
Schistosoma mansoni troponin I 0.0129 0.144 0.144
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0391 0.1127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.338 0.9997
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0022 0.0121 0.0237
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0089 0.0138
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0022 0.0121 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0115 0.1271 0.1977
Schistosoma mansoni cpg binding protein 0.0036 0.0297 0.0297
Echinococcus multilocularis L aminoadipate semialdehyde 0.0099 0.1077 0.1077
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.062 0.1807
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0688 0.8314 1
Brugia malayi jmjC domain containing protein 0.0022 0.0121 0.0188
Brugia malayi jmjC domain containing protein 0.0022 0.0121 0.0188
Echinococcus granulosus Chromobox protein 3 0.0013 0.0011 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6722 0.6722
Loa Loa (eye worm) hypothetical protein 0.0084 0.0887 0.1379
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.062 0.9102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0264
Schistosoma mansoni lozenge 0.0067 0.0679 0.0679
Brugia malayi beta-lactamase 0.004 0.0349 0.0542
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0649 0.9524
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0246 0.0383
Schistosoma mansoni chromobox protein 0.0078 0.0811 0.0811
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0172 0.0172
Schistosoma mansoni phosphatidylserine receptor 0.0022 0.0121 0.0121
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.016 0.1822 0.282
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.2539 0.7503
Schistosoma mansoni importin beta-1 0.0035 0.0283 0.0283
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0557 0.2159
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0287 0.338 0.5254
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0011 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi jmjC domain containing protein 0.0022 0.0121 0.0188
Brugia malayi chromobox protein homolog 3 0.0044 0.0391 0.0607
Loa Loa (eye worm) hypothetical protein 0.0044 0.0391 0.0607
Echinococcus granulosus geminin 0.0205 0.2371 0.2371
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 0.4003 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0835 0.0835
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0089 0.0089
Entamoeba histolytica hypothetical protein 0.0028 0.0198 0.074
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0089 0.0156
Brugia malayi hypothetical protein 0.0531 0.6383 0.9923
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0089 0.1306
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0661 0.0661
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0059 0.0141
Brugia malayi CHD4 protein 0.0017 0.0062 0.0096
Brugia malayi Troponin I 0.0129 0.144 0.2239
Trichomonas vaginalis esterase, putative 0.004 0.0349 0.1003
Loa Loa (eye worm) hypothetical protein 0.0099 0.1077 0.1674
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0349 0.1003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0795 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0011 0.0017
Echinococcus multilocularis troponin i 0.0129 0.144 0.144
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0534 0.0534
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0702 0.0702
Entamoeba histolytica hypothetical protein 0.0014 0.0027 0.0064
Echinococcus multilocularis chromobox protein 1 0.0078 0.0811 0.0811
Trichomonas vaginalis hypothetical protein 0.0041 0.0357 0.1028
Brugia malayi Bromodomain containing protein 0.007 0.0716 0.1113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0595 0.0924
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0595 0.0924
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2954 0.4592
Mycobacterium ulcerans hypothetical protein 0.0178 0.2039 0.2332
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.1257 0.1257
Brugia malayi Importin beta-1 subunit 0.0035 0.0283 0.0439
Onchocerca volvulus Alhambra homolog 0.0067 0.0681 0.1043
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0349 0.1003
Schistosoma mansoni hypothetical protein 0.0114 0.1261 0.1261
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0563 0.0563
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0349 0.0349
Schistosoma mansoni jumonji domain containing protein 0.0175 0.2005 0.2005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0835 0.2031
Echinococcus multilocularis JmjC domain containing protein 4 0.0022 0.0121 0.0121
Brugia malayi Troponin T 0.0076 0.0795 0.1236
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0349 0.0266
Loa Loa (eye worm) hypothetical protein 0.0535 0.6432 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0431 0.0655
Plasmodium vivax SET domain protein, putative 0.0037 0.0306 0.4407
Onchocerca volvulus Glucosylceramidase homolog 0.0188 0.2167 0.3358
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2292 0.6769
Onchocerca volvulus 0.004 0.0349 0.0526
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Schistosoma mansoni hypothetical protein 0.0355 0.4216 0.4216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0835 0.2031
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0349 0.0349
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0089 0.0089
Echinococcus granulosus importin subunit beta 1 0.0035 0.0283 0.0283
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0202 0.0439
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0089 0.0089
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0089 0.0116
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0207 0.0207
Echinococcus granulosus chromobox protein 1 0.0078 0.0811 0.0811
Brugia malayi jmjC domain containing protein 0.0022 0.0121 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0811 0.2375
Trypanosoma cruzi ISWI complex protein 0.0018 0.0082 0.0137
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0000000002376
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0218 0.2539 0.6305
Brugia malayi hypothetical protein 0.0084 0.0887 0.1379
Trypanosoma cruzi polo-like protein kinase, putative 0.0218 0.2539 0.6319
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0138
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0043 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.009 0.1324
Echinococcus granulosus lysine specific demethylase 5A 0.0085 0.0906 0.0906
Onchocerca volvulus 0.0535 0.6432 1
Brugia malayi MAP kinase sur-1 0.0062 0.062 0.0963
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0198 0.2909
Loa Loa (eye worm) hypothetical protein 0.0034 0.0275 0.0427
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0022 0.0121 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2167 0.64
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0121 0.0188
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0688 0.8314 1
Schistosoma mansoni tsg101-related 0.0057 0.0557 0.0557
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0124 0.1828
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0089 0.1306

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 5.23 uM PUBCHEM_BIOASSAY: Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504439] ChEMBL. No reference
AC50 (binding) = 7.59 uM PUBCHEM_BIOASSAY: Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504540] ChEMBL. No reference
AC50 (binding) = 15.513 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
AC50 (functional) = 16.473 uM PUBCHEM_BIOASSAY: 24 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
EC50 (binding) = 1.113 uM PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493008, AID493018, AID504382, AID504383] ChEMBL. No reference
Max_Activity_Concent (functional) 0.38 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Max_Concentration (binding) 50 uM PubChem BioAssay. Counterscreen to eliminate false positive from thermal shift assay Measured in Biochemical System Using Plate Reader - 2119-07_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8356 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 4.6061 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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