Detailed information for compound 1243723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.444 | Formula: C23H22N4O6
  • H donors: 2 H acceptors: 5 LogP: 1.21 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)C(=O)COC(=O)c1ccc(cc1)C=O
  • InChi: 1S/C23H22N4O6/c1-2-26(18(29)14-33-22(31)17-10-8-16(13-28)9-11-17)19-20(24)27(23(32)25-21(19)30)12-15-6-4-3-5-7-15/h3-11,13H,2,12,14,24H2,1H3,(H,25,30,32)
  • InChiKey: BCXHCVOFVBYNPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0107 0.1086 0.2112
Onchocerca volvulus 0.0024 0.0106 0.0087
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0293 0.3279 0.7104
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0293 0.3279 0.3246
Schistosoma mansoni hypothetical protein 0.0064 0.0575 0.1202
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1226 0.1183
Brugia malayi hypothetical protein 0.002 0.0057 0.0111
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0022 0.0082 0.0257
Schistosoma mansoni opsin-like receptor 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0294
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0106 0.0206
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0256 0.0208
Loa Loa (eye worm) hypothetical protein 0.0154 0.1633 0.3176
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0022 0.0082 0.0292
Brugia malayi Bromodomain containing protein 0.0087 0.0846 0.1646
Schistosoma mansoni ap endonuclease 0.0037 0.0261 0.0516
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0575 0.0529
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Onchocerca volvulus 0.0024 0.0106 0.0087
Onchocerca volvulus 0.0107 0.1086 0.1831
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Brugia malayi ORL1-like opioid receptor 0.0024 0.0106 0.0206
Echinococcus granulosus allatostatin A receptor 0.0024 0.0106 0.0126
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1247 0.2673
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0575 0.1119
Brugia malayi hypothetical protein 0.0152 0.162 0.3151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0166 0.0328
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0256 0.1969
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0256 0.1734
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0156 0.1664 0.3236
Schistosoma mansoni ap endonuclease 0.0037 0.0261 0.0516
Echinococcus multilocularis expressed conserved protein 0.0112 0.1141 0.1098
Brugia malayi AF-10 protein 0.0029 0.017 0.0331
Mycobacterium ulcerans hypothetical protein 0.0107 0.1086 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0156 0.1664 0.3585
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0231 0.2546 0.4429
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0106 0.0058
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0138 0.0268
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0537
Echinococcus granulosus peregrin 0.0096 0.0952 0.1986
Schistosoma mansoni hypothetical protein 0.0029 0.017 0.0317
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0106 0.0058
Brugia malayi vesicular acetylcholine transporter unc-17 0.0231 0.2546 0.4951
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0264 0.0474
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0106 0.0206
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0069
Brugia malayi Doublecortin family protein 0.002 0.0057 0.0111
Schistosoma mansoni biogenic amine receptor 0.0024 0.0106 0.0176
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0106 0.0058
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Echinococcus multilocularis sex peptide receptor 0.0024 0.0106 0.0058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0106 0.0087
Loa Loa (eye worm) hypothetical protein 0.0121 0.1251 0.2433
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0107 0.1086 0.2112
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1827 0.1787
Trypanosoma brucei C-8 sterol isomerase, putative 0.038 0.4305 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0101
Echinococcus granulosus g protein coupled receptor 0.0024 0.0106 0.0126
Onchocerca volvulus 0.0026 0.0138 0.0144
Loa Loa (eye worm) PHD-finger family protein 0.009 0.088 0.1712
Onchocerca volvulus 0.0024 0.0106 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1409 0.3028
Onchocerca volvulus 0.0024 0.0106 0.0087
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0138 0.0246
Loa Loa (eye worm) hypothetical protein 0.0062 0.0562 0.1092
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0106 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0563 0.1176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0106 0.0176
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0138 0.0196
Loa Loa (eye worm) hypothetical protein 0.0082 0.0786 0.1528
Entamoeba histolytica hypothetical protein 0.0037 0.0264 0.1809
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0106 0.0206
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1086 0.1839
Loa Loa (eye worm) hypothetical protein 0.0043 0.0327 0.0636
Loa Loa (eye worm) hypothetical protein 0.0152 0.162 0.3151
Brugia malayi jmjC domain containing protein 0.0029 0.0166 0.0323
Echinococcus granulosus neuropeptide receptor 0.0024 0.0106 0.0126
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0106 0.0126
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1226 0.2589
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0575 0.0529
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Onchocerca volvulus 0.0107 0.1086 0.1831
Mycobacterium tuberculosis Conserved protein 0.0107 0.1086 0.1142
Echinococcus granulosus lamin 0.0028 0.0151 0.0225
Onchocerca volvulus 0.0026 0.0138 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0427 0.0666
Brugia malayi PHD-finger family protein 0.009 0.088 0.1712
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1086 0.232
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.1445 0.281
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1409 0.3028
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0009
Echinococcus granulosus g protein coupled receptor 0.0024 0.0106 0.0126
Plasmodium vivax JmjC domain containing protein 0.0029 0.0166 0.1059
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0106 0.0176
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0106 0.0126
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0138 0.0246
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0106 0.0176
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1265 0.246
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0052 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0052 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.011 0.1127 0.241
Loa Loa (eye worm) hypothetical protein 0.0029 0.0166 0.0323
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0106 0.0126
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0106 0.0058
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0261 0.2528
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1086 0.1839
Loa Loa (eye worm) hypothetical protein 0.0156 0.1664 0.3236
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1086 0.2478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1226 1
Schistosoma mansoni vesicular acetylcholine transporter 0.0231 0.2546 0.5514
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0082 0.0054
Loa Loa (eye worm) acetyltransferase 0.0144 0.1519 0.2954
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0256 0.0362
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1086 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0052 0.0061
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0138 0.0196
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0138 0.0246
Echinococcus granulosus hypothetical protein 0.0024 0.0106 0.0126
Loa Loa (eye worm) beta-lactamase 0.0107 0.1086 0.2112
Schistosoma mansoni patched 1 0.0051 0.0427 0.0877
Onchocerca volvulus 0.0028 0.0151 0.0167
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0106 0.0058
Onchocerca volvulus 0.0024 0.0106 0.0087
Brugia malayi hypothetical protein 0.0026 0.0138 0.0268
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1086 0.1142
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0274 0.268
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0346 0.2839
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0786 0.1663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.0451 0.5142 1
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Brugia malayi PHD-finger family protein 0.0031 0.0192 0.0373
Loa Loa (eye worm) hypothetical protein 0.0119 0.1226 0.2384
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0261 0.0551
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0106 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1409 0.3028
Onchocerca volvulus 0.0026 0.0138 0.0144
Brugia malayi Serotonin receptor 0.0024 0.0106 0.0206
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0106 0.0176
Brugia malayi Serotonin receptor 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0107 0.1086 0.2112
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0166 0.0118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0575 0.1119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Onchocerca volvulus Alhambra homolog 0.009 0.088 0.1465
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0106 0.0206
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Onchocerca volvulus 0.0024 0.0106 0.0087
Brugia malayi Dopamine receptor protein 2 0.0024 0.0106 0.0206
Schistosoma mansoni hypothetical protein 0.0064 0.0575 0.1202
Schistosoma mansoni hypothetical protein 0.0049 0.0405 0.083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0106 0.0126
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0138 0.0246
Onchocerca volvulus 0.0024 0.0106 0.0087
Loa Loa (eye worm) hypothetical protein 0.0245 0.2708 0.5266
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0106 0.0206
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0346 0.0522
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus serotonin receptor 0.0024 0.0106 0.0126
Brugia malayi Serine carboxypeptidase S28 family protein 0.0022 0.0082 0.016
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0106 0.0058
Echinococcus granulosus lysine specific demethylase 5A 0.011 0.1127 0.2371
Echinococcus multilocularis serotonin transporter 0.0156 0.1664 0.1623
Schistosoma mansoni amine GPCR 0.0195 0.212 0.4584
Echinococcus multilocularis lamin 0.0028 0.0151 0.0103
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0106 0.0126
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0106 0.0058
Schistosoma mansoni lamin 0.0028 0.0151 0.0274
Leishmania major C-8 sterol isomerase-like protein 0.038 0.4305 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0261 0.0372
Loa Loa (eye worm) hypothetical protein 0.009 0.088 0.1712
Toxoplasma gondii hypothetical protein 0.0026 0.0138 0.0831
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0026 0.0138 0.009
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0022 0.0082 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0282
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0261 0.0508
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0231 0.2546 0.4951
Onchocerca volvulus 0.0028 0.0151 0.0167
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0538 0.1198
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0106 0.0058
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0405 0.4596 1
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0436 0.4966 0.9657
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0563 0.4942
Brugia malayi intermediate filament protein 0.0028 0.0151 0.0294
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0106 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0261 0.2528
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Schistosoma mansoni lipoxygenase 0.0082 0.0793 0.1679
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0022 0.0082 0.0124
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1086 0.2112
Echinococcus multilocularis protein patched 0.0051 0.0427 0.038
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0261 0.0372
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0106 0.0126
Toxoplasma gondii exonuclease III APE 0.0037 0.0261 0.2024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0831
Echinococcus multilocularis protein dispatched 1 0.0058 0.0512 0.0465
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0346 0.2839
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0261 0.0551
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0106 0.0206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.1409 0.2993
Schistosoma mansoni DNA helicase recq5 0.0019 0.0052 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0684 0.7877 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0022 0.0082 0.0257
Schistosoma mansoni zinc finger protein 0.0025 0.0122 0.0211
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0166 0.0323
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0166 0.0307
Schistosoma mansoni biogenic amine receptor 0.0024 0.0106 0.0176
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0022 0.0082 0.0054
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0106 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Brugia malayi larval opioid receptor 0.0024 0.0106 0.0206
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0575 0.1158
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0538 0.1077
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0176
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0575 0.1119
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0261 0.0551
Echinococcus granulosus neuropeptide receptor 0.0024 0.0106 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.1409 0.2993
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0537
Schistosoma mansoni bromodomain containing protein 0.0074 0.0693 0.1461
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1086 0.1043
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0274 0.268
Echinococcus granulosus bloom syndrome protein 0.0019 0.0052 0.0007
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0106 0.0126
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0538 0.4702
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0268
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0138 0.009
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0106 0.0126
Echinococcus multilocularis lamin dm0 0.0028 0.0151 0.0103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis serotonin receptor 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Schistosoma mansoni lipoxygenase 0.0118 0.1209 0.259
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0022 0.0082 0.0034
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Mycobacterium tuberculosis Conserved protein 0.0107 0.1086 0.1142
Schistosoma mansoni hypothetical protein 0.0064 0.0575 0.1202
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0261 0.0508
Plasmodium vivax amine transporter, putative 0.0026 0.0138 0.0785
Onchocerca volvulus 0.0024 0.0106 0.0087
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1226 0.2384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Mycobacterium leprae Probable lipase LipE 0.0107 0.1086 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0166 0.0323
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.0107 0.1086 0.2112
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0256 0.0455
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Echinococcus granulosus phd:f box containing protein 0.0029 0.0166 0.0259
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni polycystin 1-related 0.002 0.0057 0.0069
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0106 0.0126
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0106 0.0058
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0121 0.1251 0.2433
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0151 0.0294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.2194 0.4267
Onchocerca volvulus 0.0024 0.0106 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0052 0.0007
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0405 0.4596 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.0138 0.009
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0106 0.0176
Brugia malayi Bromodomain containing protein 0.0096 0.0952 0.1851
Onchocerca volvulus 0.0024 0.0106 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0538 0.3403
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0106 0.0058
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1086 0.1839
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0106 0.0206
Loa Loa (eye worm) norepinephrine transporter 0.0156 0.1664 0.3236
Echinococcus multilocularis vesicular acetylcholine transporter 0.0231 0.2546 0.2509
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0106 0.0126
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0538 0.0427
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0106 0.0206
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0106 0.0176
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0405 0.4596 0.4569
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1086 0.1142
Schistosoma mansoni survival motor neuron protein 0.005 0.0414 0.0849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.1409 0.1368
Schistosoma mansoni hypothetical protein 0.0037 0.0264 0.0522
Onchocerca volvulus 0.0063 0.0563 0.09
Echinococcus granulosus g protein coupled receptor 0.0024 0.0106 0.0126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0106 0.0058
Brugia malayi Serine protease Z688.6 precursor 0.0022 0.0082 0.016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.00000000099579
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0106 0.0206
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0261 0.1783
Entamoeba histolytica hypothetical protein 0.0037 0.0264 0.1809
Brugia malayi hypothetical protein 0.002 0.0057 0.0111
Brugia malayi CHE-14 protein 0.0051 0.0427 0.083
Loa Loa (eye worm) hypothetical protein 0.0201 0.2194 0.4267
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1086 0.2112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.088 0.8009
Echinococcus granulosus fmrfamide receptor 0.0024 0.0106 0.0126
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.012 0.0072
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1519 0.2954
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2194 0.4267
Plasmodium falciparum amino acid transporter, putative 0.0026 0.0138 0.1038
Schistosoma mansoni hypothetical protein 0.009 0.088 0.187
Onchocerca volvulus 0.0156 0.1664 0.286
Leishmania major hypothetical protein, conserved 0.0107 0.1086 0.2478
Schistosoma mansoni adenoreceptor 0.0024 0.0106 0.0176
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0022 0.0082 0.0132
Giardia lamblia Thymus-specific serine protease precursor 0.0022 0.0082 0.0365
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Brugia malayi beta-lactamase family protein 0.0107 0.1086 0.2112
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0536 0.1072
Trypanosoma cruzi C-8 sterol isomerase, putative 0.038 0.4305 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0106 0.0126
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0022 0.0082 0.0132
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0106 0.0206
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0052 0.0003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0106 0.0058
Brugia malayi RE15519p 0.0024 0.0106 0.0206
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0646 0.0601
Brugia malayi PHD-finger family protein 0.0031 0.0195 0.038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0424 0.0824
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0052 0.0003
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0138 0.0196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0106 0.0126
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1827 0.391
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1086 0.1142
Schistosoma mansoni loxhd1 0.002 0.0057 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0138 0.0785
Echinococcus multilocularis geminin 0.0167 0.1797 0.1757
Schistosoma mansoni neuropeptide receptor 0.0024 0.0106 0.0176
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0106 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1086 0.1839
Loa Loa (eye worm) solute carrier family 6 member 4 0.0156 0.1664 0.3236
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0538 0.3403
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Brugia malayi Pre-SET motif family protein 0.0063 0.0563 0.1095
Leishmania major hypothetical protein, conserved 0.0029 0.0166 0.0328
Echinococcus multilocularis peregrin 0.0096 0.0952 0.0908
Echinococcus granulosus PHD finger protein rhinoceros 0.009 0.088 0.1829
Schistosoma mansoni amine GPCR 0.0024 0.0106 0.0176
Onchocerca volvulus 0.0107 0.1086 0.1831
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0106 0.0176
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus zinc finger protein 0.0025 0.0122 0.0162
Mycobacterium ulcerans beta-lactamase 0.0107 0.1086 1
Plasmodium falciparum phd finger protein, putative 0.009 0.088 1
Schistosoma mansoni neuropeptide receptor 0.0024 0.0106 0.0176
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.1409 0.2741
Schistosoma mansoni opsin-like receptor 0.0024 0.0106 0.0176
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0537
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.0069
Brugia malayi jmjC domain containing protein 0.0029 0.0166 0.0323
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Onchocerca volvulus 0.0024 0.0106 0.0087
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0052 0.0101
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.017 0.1146
Brugia malayi sulfakinin receptor protein 0.0024 0.0106 0.0206
Echinococcus multilocularis RUN 0.002 0.0057 0.0009
Onchocerca volvulus 0.005 0.0414 0.0635
Schistosoma mansoni opsin-like receptor 0.0024 0.0106 0.0176
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0106 0.0126
Onchocerca volvulus 0.0022 0.0082 0.0045
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0166 0.1379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Toxoplasma gondii hypothetical protein 0.0026 0.0138 0.0831
Onchocerca volvulus Huntingtin homolog 0.0121 0.1251 0.2125
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0106 0.0058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1441 0.3063
Loa Loa (eye worm) hypothetical protein 0.0194 0.2115 0.4113
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.012 0.0158
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0166 0.0307
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1086 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0166 0.1104
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0138 0.0246
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0026 0.0138 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0106 0.0176
Brugia malayi Dopamine receptor protein 1 0.0451 0.5142 1
Giardia lamblia PHD finger protein 15 0.009 0.088 1
Echinococcus granulosus lamin dm0 0.0028 0.0151 0.0225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0575 0.1158
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0106 0.0206
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0106 0.0206
Onchocerca volvulus 0.0152 0.162 0.2782
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.0101
Echinococcus granulosus intermediate filament protein 0.0028 0.0151 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0563 0.1176
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0268
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0538 0.0492
Brugia malayi jmjC domain containing protein 0.0029 0.0166 0.0323
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.2708 0.5848
Brugia malayi jmjC domain containing protein 0.011 0.1127 0.2192
Echinococcus granulosus GPCR family 2 0.0064 0.0575 0.1158
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0106 0.0058
Brugia malayi beta-lactamase 0.0107 0.1086 0.2112
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0538 0.1121
Brugia malayi jmjC domain containing protein 0.0293 0.3279 0.6376
Plasmodium vivax SET domain protein, putative 0.0063 0.0563 0.4917
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0166 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0022 0.0082 0.0132
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0106 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Loa Loa (eye worm) doublecortin family protein 0.002 0.0057 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Entamoeba histolytica hypothetical protein 0.0037 0.0264 0.1809
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni sodium/chloride dependent transporter 0.0156 0.1664 0.3585
Brugia malayi neuropeptide F receptor 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.1119
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0052 0.0061
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.2992 0.5818
Onchocerca volvulus 0.0024 0.0106 0.0087
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1086 0.1142
Schistosoma mansoni hypothetical protein 0.0049 0.0405 0.083
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0166 0.0259
Brugia malayi Melatonin receptor type 1A 0.0024 0.0106 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.1409 0.1368
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.088 0.8009
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1086 0.1839
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.0786 0.1621
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.1209 0.2553
Brugia malayi neuropeptide F receptor 0.0024 0.0106 0.0206
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni hypothetical protein 0.0137 0.1445 0.3105
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1086 0.2478
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0166 0.0323
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0106 0.0126
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.0101
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0106 0.0126
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0831
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.009 0.088 0.187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0106 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0106 0.0126
Brugia malayi MH2 domain containing protein 0.0122 0.1265 0.246
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0166 0.0118
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0346 0.0522
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0166 0.0259
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0166 0.0307
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0057 0.0063
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0138 0.0246
Onchocerca volvulus 0.0024 0.0106 0.0087
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0346 0.2803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1086 0.1142
Schistosoma mansoni lamin 0.0028 0.0151 0.0274
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.0138 0.009
Schistosoma mansoni amine GPCR 0.0024 0.0106 0.0176
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1265 0.246
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0106 0.0058
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0106 0.0206
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0166 0.0118
Schistosoma mansoni hypothetical protein 0.0049 0.0405 0.083
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0256 0.0362
Loa Loa (eye worm) inositol-1 0.0036 0.0256 0.0497
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0176
Schistosoma mansoni jumonji domain containing protein 0.0233 0.2569 0.5566
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis GPCR, family 2 0.0064 0.0575 0.0529
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0176
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0106 0.0176
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.2708 0.2672
Echinococcus granulosus geminin 0.0167 0.1797 0.3846
Echinococcus multilocularis musashi 0.0028 0.0151 0.0103
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0166 0.0118
Loa Loa (eye worm) serotonin transporter b 0.0156 0.1664 0.3236
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0414 0.0805
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0261 0.0214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0261 0.0551
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Onchocerca volvulus 0.0497 0.5676 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1445 0.281
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0427 0.083
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0097 0.0189
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1519 0.3267
Echinococcus granulosus vesicular acetylcholine transporter 0.0231 0.2546 0.5492
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0191 0.0313
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1086 0.1142
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0106 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0166 0.0323
Echinococcus granulosus orexin receptor type 2 0.0024 0.0106 0.0126
Brugia malayi hypothetical protein 0.0245 0.2708 0.5266
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0106 0.0058
Brugia malayi Bromodomain containing protein 0.0046 0.0367 0.0713
Schistosoma mansoni neuropeptide receptor 0.0024 0.0106 0.0176
Loa Loa (eye worm) jmjC domain-containing protein 0.0185 0.2003 0.3895
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0138 0.009
Onchocerca volvulus 0.0024 0.0106 0.0087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.1209 0.1167
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0261 0.1984
Echinococcus multilocularis zinc finger protein 0.0025 0.0122 0.0074
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0191 0.0143
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0151 0.0294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0106 0.0176
Echinococcus multilocularis serotonin receptor 0.0024 0.0106 0.0058
Schistosoma mansoni hypothetical protein 0.0167 0.1797 0.3876
Loa Loa (eye worm) hypothetical protein 0.0031 0.0195 0.038
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0106 0.0176
Brugia malayi Pre-SET motif family protein 0.0436 0.4966 0.9657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0111
Loa Loa (eye worm) jmjC domain-containing protein 0.011 0.1127 0.2192
Plasmodium vivax hypothetical protein, conserved 0.0029 0.017 0.1101
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0095 0.0185
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0256 0.0362
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.016
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0346 0.0653
Treponema pallidum sodium- and chloride- dependent transporter 0.0156 0.1664 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0256 0.0503
Echinococcus granulosus serotonin transporter 0.0156 0.1664 0.3553
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0223 0.0433
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0537
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0166 0.0259
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0022 0.0082 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0264 0.0217
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0106 0.0126
Schistosoma mansoni amine GPCR 0.0024 0.0106 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Schistosoma mansoni neuropeptide receptor 0.0024 0.0106 0.0176
Schistosoma mansoni hypothetical protein 0.0023 0.0095 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0427 0.083
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0106 0.0176
Schistosoma mansoni DNA helicase recq1 0.0019 0.0052 0.0057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0138 0.0246
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0261 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Brugia malayi G-protein coupled receptor 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis somatostatin receptor 0.0024 0.0106 0.0058
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.012 0.0207
Schistosoma mansoni myosin xvIII 0.0024 0.0106 0.0176
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0646 0.1315
Brugia malayi G protein-coupled receptor 0.0024 0.0106 0.0206
Brugia malayi hypothetical protein 0.0121 0.1251 0.2433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.0786 0.0741
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0261 0.0069
Giardia lamblia Serine peptidase, putative 0.0022 0.0082 0.0365
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0261 1
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0106 0.0126
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0106 0.0126
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0538 0.1121
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Toxoplasma gondii ABC1 family protein 0.0107 0.1086 1
Echinococcus granulosus RUN 0.002 0.0057 0.0019
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0106 0.0058
Echinococcus granulosus sex peptide receptor 0.0024 0.0106 0.0126
Schistosoma mansoni intermediate filament proteins 0.0028 0.0151 0.0274
Brugia malayi Dopamine receptor 0.0024 0.0106 0.0206
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0022 0.0082 0.0257
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.017 0.1146
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.016
Echinococcus multilocularis jumonji domain containing protein 0.0125 0.1293 0.1251
Loa Loa (eye worm) hypothetical protein 0.0107 0.1086 0.2112
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0268
Brugia malayi putative neuropeptide receptor 0.0024 0.0106 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0106 0.0176
Brugia malayi jmjC domain containing protein 0.0029 0.0166 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1086 0.2478
Brugia malayi ERG2 and Sigma1 receptor like protein 0.038 0.4305 0.8371
Brugia malayi GnHR receptor homolog 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0106 0.0126
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0166 0.1104
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0106 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2194 0.4267
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0427 0.0831
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0106 0.0058
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0427 0.0831
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0057 0.0009
Schistosoma mansoni amine GPCR 0.0024 0.0106 0.0176
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0106 0.0206
Schistosoma mansoni hypothetical protein 0.005 0.0414 0.0849
Loa Loa (eye worm) RecQ helicase 0.0019 0.0052 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0106 0.0126
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1086 0.2282
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0198 0.0376
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0138 0.0831
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Onchocerca volvulus 0.0024 0.0106 0.0087
Trichomonas vaginalis esterase, putative 0.0107 0.1086 0.1839
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0786 0.1663
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0049 0.0399 0.0775
Loa Loa (eye worm) hypothetical protein 0.0107 0.1086 0.2112
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0026 0.0138 0.0196
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0106 0.0126
Onchocerca volvulus 0.0024 0.0106 0.0087
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0106 0.0058
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.0138 0.0196
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.017 0.0338
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis PHD finger protein rhinoceros 0.009 0.088 0.0836
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0106 0.0176
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0106 0.0058
Mycobacterium tuberculosis Conserved protein 0.0107 0.1086 0.1142
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Entamoeba histolytica hypothetical protein 0.0037 0.0264 0.1809
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0106 0.0058
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0295 0.0248
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0295 0.0542
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0106 0.0058
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0274 0.1891
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.1409 0.2741
Loa Loa (eye worm) hypothetical protein 0.0078 0.075 0.1458
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0138 0.0246
Plasmodium falciparum transporter, putative 0.0026 0.0138 0.1038
Mycobacterium ulcerans lipase LipD 0.0107 0.1086 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0166 0.0328
Onchocerca volvulus 0.0024 0.0106 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0106 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0106 0.0058
Schistosoma mansoni inositol monophosphatase 0.0036 0.0256 0.0503
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0049 0.005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0106 0.0176
Brugia malayi Serine protease Z688.6 precursor 0.0022 0.0082 0.016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0138 0.0246
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0151 0.0294
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0106 0.0126
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0563 0.0517
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0166 0.0328
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0166 0.0307
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0138 0.0196
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0261 0.0066
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1086 0.1142
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0156 0.1664 0.3236
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0057 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0538 0.3403
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.038 0.4305 0.8371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0009
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1086 1
Schistosoma mansoni biogenic amine receptor 0.0024 0.0106 0.0176
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1086 1
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0106 0.0058
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1519 0.1477
Schistosoma mansoni hypothetical protein 0.0064 0.0575 0.1202
Schistosoma mansoni jumonji/arid domain-containing protein 0.011 0.1127 0.241
Plasmodium vivax hypothetical protein, conserved 0.009 0.088 0.7999
Echinococcus granulosus jumonji domain containing protein 0.0125 0.1293 0.2737
Echinococcus granulosus expressed conserved protein 0.0112 0.1141 0.2402
Brugia malayi follicle stimulating hormone receptor 0.0269 0.2992 0.5818
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0111
Brugia malayi G-protein coupled receptor 0.0024 0.0106 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0106 0.0126
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0106 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0138 0.0246
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0138 0.0246
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.017 0.1431
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0052 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1086 0.232
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.1102 0.1059
Brugia malayi hypothetical protein 0.0024 0.0106 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0106 0.0176
Brugia malayi Inositol-1 0.0036 0.0256 0.0497
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Brugia malayi AKH receptor 0.0024 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.1664 0.3236
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Schistosoma mansoni hypothetical protein 0.0049 0.0405 0.083
Echinococcus granulosus somatostatin receptor 0.0024 0.0106 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0082 0.0054
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.0069
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0106 0.0176
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0264 0.0522
Loa Loa (eye worm) hypothetical protein 0.0107 0.1086 0.2112
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0106 0.0206
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0106 0.0058
Schistosoma mansoni hypothetical protein 0.0167 0.1797 0.3876
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0022 0.0082 0.0054
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0106 0.0087
Brugia malayi hypothetical protein 0.0037 0.0264 0.0514
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0206
Trichomonas vaginalis set domain proteins, putative 0.0497 0.5676 1
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0022 0.0082 0.0054
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.017 0.0338
Onchocerca volvulus Huntingtin homolog 0.0121 0.1251 0.2125
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0427 0.038
Schistosoma mansoni histamine h1 receptor 0.0024 0.0106 0.0176

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 122.492 uM PubChem BioAssay. Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) 122.492 uM PubChem BioAssay. Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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