Detailed information for compound 1302035

Basic information

Technical information
  • TDR Targets ID: 1302035
  • Name: N-[(2-prop-2-enoxyphenyl)methyl]tetrazole-1,5 -diamine
  • MW: 246.268 | Formula: C11H14N6O
  • H donors: 2 H acceptors: 3 LogP: 1.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccccc1CNn1nnnc1N
  • InChi: 1S/C11H14N6O/c1-2-7-18-10-6-4-3-5-9(10)8-13-17-11(12)14-15-16-17/h2-6,13H,1,7-8H2,(H2,12,14,16)
  • InChiKey: WGUBYIANRTZAKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-allyloxyphenyl)methyl]tetrazole-1,5-diamine
  • (2-allyloxybenzyl)-(5-aminotetrazol-1-yl)amine
  • N-[(2-prop-2-enoxyphenyl)methyl]-1,2,3,4-tetrazole-1,5-diamine
  • ZINC02861052
  • MLS000050308
  • N~1~-[2-(allyloxy)benzyl]-1H-tetrazole-1,5-diamine
  • SMR000077522
  • BAS 07017368
  • N*1*-(2-Allyloxy-benzyl)-tetrazole-1,5-diamine
  • T5487201
  • AP-970/42167829

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.007 0.0722 0.0669
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.1833 0.217
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0391 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0477 0.0474
Loa Loa (eye worm) hypothetical protein 0.0045 0.0374 0.0374
Brugia malayi Cytochrome P450 family protein 0.0048 0.0405 0.0405
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0083 0.0223
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0542 0.3024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0542 0.1988
Loa Loa (eye worm) hypothetical protein 0.0161 0.2003 0.2003
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0212 0.2727 0.4451
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0477 0.083
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0057 0.0542 0.1814
Echinococcus granulosus cathepsin b 0.0425 0.5743 0.5741
Brugia malayi PHD-finger family protein 0.0024 0.0076 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3294 0.3981
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0542 0.0569
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0477 0.0474
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0477 0.0477
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0722 0.072
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.011 0.1285 0.3875
Toxoplasma gondii phosphofructokinase PFKII 0.0057 0.0542 0.1419
Giardia lamblia Alanyl dipeptidyl peptidase 0.0071 0.073 0.3695
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0396 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0057 0.0211
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0542 0.0291
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.011 0.1285 0.3875
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0212 0.2727 0.8221
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0083 0.0223
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0482 0.0479
Echinococcus multilocularis cysteine protease 0.0079 0.0856 0.0854
Mycobacterium leprae Probable lipase LipE 0.007 0.0722 0.2491
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0083 0.008
Brugia malayi Bromodomain containing protein 0.0073 0.0767 0.0767
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0083 0.0144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0542 0.054
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0726 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0542 0.0569
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0083 0.0026
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0057 0.0542 0.2862
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0477 0.225
Toxoplasma gondii prolyl endopeptidase 0.0191 0.2428 0.725
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0212 0.2727 0.4748
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0477 0.083
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0477 0.1571
Brugia malayi Cathepsin L-like precursor 0.0079 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.007 0.0722 0.0722
Brugia malayi Cathepsin L-like precursor 0.0057 0.0543 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Mycobacterium tuberculosis Conserved protein 0.007 0.0722 0.1109
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0253 0.3317 0.5776
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0138 0.1686 0.2935
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0722 0.0722
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0083 0.0223
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0071 0.073 0.0802
Plasmodium vivax unspecified product 0.0047 0.0396 0.2136
Brugia malayi Cathepsin L-like precursor 0.0079 0.0856 0.0856
Entamoeba histolytica cysteine protease, putative 0.0025 0.0083 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0361 0.0361
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0396 0.127
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0856 0.1491
Brugia malayi cathepsin B-like cysteine proteinase 0.0425 0.5743 0.5743
Giardia lamblia Cathepsin B precursor 0.0149 0.1833 1
Schistosoma mansoni hypothetical protein 0.0352 0.4714 0.4712
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0477 0.0488
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0477 0.1437
Loa Loa (eye worm) cysteine protease 0.0079 0.0856 0.0856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Plasmodium vivax GPI-anchor transamidase, putative 0.0138 0.1686 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0079 0.0856 0.0854
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0482 0.0479
Brugia malayi Cathepsin L-like precursor 0.0022 0.0046 0.0046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0856 0.0854
Giardia lamblia Cathepsin B precursor 0.0149 0.1833 1
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0856 0.1491
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.3294 0.3294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0542 0.2865
Loa Loa (eye worm) hypothetical protein 0.0057 0.0543 0.0543
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0361 0.0358
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0542 0.1816
Echinococcus granulosus cysteine protease 0.0047 0.0396 0.0394
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.2488 0.2486
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0405 0.0405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0425 0.5743 0.5741
Echinococcus multilocularis 6 phosphofructokinase 0.0212 0.2727 0.2725
Mycobacterium ulcerans hypothetical protein 0.007 0.0722 0.2649
Brugia malayi hypothetical protein 0.0251 0.3286 0.3286
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0391 0.0391
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0482 0.0479
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0149 0.1833 0.5527
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0425 0.5743 0.5741
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0396 0.0396
Trichomonas vaginalis immunophilin, putative 0.0053 0.0477 0.0488
Entamoeba histolytica prolyl oligopeptidase family protein 0.0071 0.073 0.2519
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0138 0.1686 0.1987
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0722 0.1258
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0726 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0083 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0083 0.008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0284 0.3754 0.3754
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0071 0.073 0.2
Brugia malayi hypothetical protein 0.0161 0.2003 0.2003
Plasmodium vivax vivapain-2 0.0079 0.0856 0.4941
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0447 0.6055 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0391 0.0388
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0722 0.0722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Onchocerca volvulus 0.0229 0.2968 0.2928
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0396 0.127
Brugia malayi Pre-SET motif family protein 0.0201 0.2575 0.2575
Plasmodium vivax hypothetical protein, conserved 0.007 0.0722 0.4123
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0722 0.1258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0361 0.0358
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0391 0.0335
Entamoeba histolytica phosphofructokinase, putative 0.0212 0.2727 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0071 0.073 0.2519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Onchocerca volvulus 0.0047 0.0391 0.0335
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0083 0.0083
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0856 0.0854
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.073 0.0802
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0083 0.008
Brugia malayi follicle stimulating hormone receptor 0.0284 0.3754 0.3754
Mycobacterium leprae conserved hypothetical protein 0.007 0.0722 0.2491
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0396 0.127
Entamoeba histolytica cysteine protease, putative 0.0025 0.0083 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3294 0.3981
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.2488 0.2486
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0212 0.2727 1
Brugia malayi 6-phosphofructokinase 0.0212 0.2727 0.2727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0722 0.1109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0722 0.2649
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0856 0.0804
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0396 0.127
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0477 0.0488
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0138 0.1686 0.5082
Brugia malayi Bromodomain containing protein 0.0037 0.0261 0.0261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0046 0.0046
Loa Loa (eye worm) 6-phosphofructokinase 0.0212 0.2727 0.2727
Brugia malayi Pre-SET motif family protein 0.0029 0.0141 0.0141
Trypanosoma brucei oligopeptidase b 0.011 0.1285 0.3875
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0228 0.0226
Schistosoma mansoni hemoglobinase (C13 family) 0.0595 0.8149 0.8149
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0543 0.0945
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0138 0.1686 0.1987
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2968 0.3577
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Echinococcus granulosus geminin 0.0352 0.4714 0.4712
Loa Loa (eye worm) beta-lactamase 0.007 0.0722 0.0722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0396 0.1195
Schistosoma mansoni hemoglobinase (C13 family) 0.0595 0.8149 0.8149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0141 0.0178
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0477 0.083
Leishmania major ATP-dependent phosphofructokinase 0.0212 0.2727 0.8221
Echinococcus granulosus acylamino acid releasing enzyme 0.0071 0.073 0.0727
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0191 0.2428 0.7319
Loa Loa (eye worm) hypothetical protein 0.0251 0.3286 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0396 0.1195
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0253 0.3317 1
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0376 0.0373
Brugia malayi hypothetical protein 0.0183 0.232 0.232
Onchocerca volvulus Cathepsin F homolog 0.0079 0.0856 0.0804
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.0046 0.0046
Loa Loa (eye worm) ctsf protein 0.0079 0.0856 0.0856
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0425 0.5743 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0141 0.0574
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.3286 0.3284
Trypanosoma brucei prolyl oligopeptidase, putative 0.011 0.1285 0.3875
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0141 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0083 0.008
Toxoplasma gondii ABC1 family protein 0.007 0.0722 0.1977
Giardia lamblia GPI-anchor transamidase, putative 0.0138 0.1686 0.9157
Trypanosoma brucei prolyl endopeptidase 0.0191 0.2428 0.7319
Loa Loa (eye worm) hypothetical protein 0.007 0.0722 0.0722
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0083 0.008
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.3286 0.3284
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0083 0.0223
Brugia malayi Peptidase C13 family protein 0.0595 0.8149 0.8149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0361 0.0361
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0057 0.0543 0.0543
Plasmodium falciparum cysteine proteinase falcipain 3 0.0079 0.0856 0.4826
Plasmodium falciparum GPI-anchor transamidase, putative 0.0138 0.1686 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0722 0.0722
Loa Loa (eye worm) peptidase C13 family protein 0.0595 0.8149 0.8149
Leishmania major cysteine peptidase A (CPA) 0.0079 0.0856 0.2582
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0856 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0482 0.0479
Entamoeba histolytica phosphofructokinase, putative 0.0212 0.2727 1
Trichomonas vaginalis phosphofructokinase, putative 0.0212 0.2727 0.3278
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0856 0.2993
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0083
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0083 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0083 0.008
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Trypanosoma cruzi prolyl endopeptidase 0.0191 0.2428 0.4227
Brugia malayi Cathepsin L-like precursor 0.0057 0.0543 0.0543
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0722 0.1109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3294 0.3981
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0396 0.0394
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2195 0.2619
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0391 0.0388
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0396 0.0396
Plasmodium vivax vivapain-3 0.0047 0.0396 0.2136
Echinococcus multilocularis cathepsin b 0.0425 0.5743 0.5741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0722 0.072
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0083 0.0095
Onchocerca volvulus 0.0079 0.0856 0.0804
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0542 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Loa Loa (eye worm) hypothetical protein 0.0191 0.2428 0.2428
Brugia malayi Cathepsin L-like precursor 0.0079 0.0856 0.0856
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0212 0.2727 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.007 0.0722 0.0722
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.1833 0.3192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0542 0.0569
Onchocerca volvulus 0.0079 0.0856 0.0804
Echinococcus multilocularis acylamino acid releasing enzyme 0.0071 0.073 0.0727
Loa Loa (eye worm) phosphofructokinase 0.0212 0.2727 0.2727
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0083 0.0083
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0253 0.3317 0.3315
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.3294 0.3294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Echinococcus multilocularis prolyl endopeptidase 0.0191 0.2428 0.2426
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0396 0.0394
Mycobacterium ulcerans hypothetical protein 0.0023 0.0057 0.0211
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0542 0.0542
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0542 0.054
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0374 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0361 0.0358
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3294 0.3981
Brugia malayi 6-phosphofructokinase 0.0212 0.2727 0.2727
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Brugia malayi Cathepsin L-like precursor 0.0079 0.0856 0.0856
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0477 0.0474
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Brugia malayi prolyl oligopeptidase family protein 0.0253 0.3317 0.3317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0361 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0083 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0722 0.0793
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Schistosoma mansoni 6-phosphofructokinase 0.0212 0.2727 0.2725
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0057 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0212 0.2727 0.3278
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0057
Schistosoma mansoni immunophilin 0.0053 0.0477 0.0474
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0396 0.069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0361 0.0358
Toxoplasma gondii peptidase c13 family protein 0.0138 0.1686 0.4956
Trypanosoma cruzi oligopeptidase b 0.011 0.1285 0.2238
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0722 0.1109
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0477 0.1437
Brugia malayi fibroinase precursor 0.0025 0.0083 0.0083
Loa Loa (eye worm) prolyl oligopeptidase 0.0071 0.073 0.073
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0057 0.0542 0.5
Entamoeba histolytica cysteine protease, putative 0.0079 0.0856 0.2993
Schistosoma mansoni immunophilin 0.0053 0.0477 0.0474
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0396 0.127
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.011 0.1285 0.4713
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0856 0.1491
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0044 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0212 0.2727 0.3278
Schistosoma mansoni hypothetical protein 0.0051 0.0457 0.0455
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3294 0.3981
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0083 0.0083
Entamoeba histolytica cysteine protease, putative 0.0025 0.0083 0.0095
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0477 0.0477
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0722 0.072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.011 0.1285 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Brugia malayi beta-lactamase family protein 0.007 0.0722 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0083 0.0223
Schistosoma mansoni immunophilin 0.0045 0.0374 0.0372
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0477 0.1571
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0542 0.0542
Onchocerca volvulus 0.0025 0.0083 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Schistosoma mansoni survival motor neuron protein 0.0051 0.0457 0.0455
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0856 0.0854
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0071 0.073 0.0727
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0391 0.0388
Brugia malayi beta-lactamase family protein 0.007 0.0722 0.0722
Entamoeba histolytica GPI-anchor transamidase, putative 0.0138 0.1686 0.61
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0138 0.1686 0.1987
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0856 0.0854
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Loa Loa (eye worm) hypothetical protein 0.0047 0.0391 0.0391
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0079 0.0856 0.0856
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.073 0.073
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0149 0.1833 0.5527
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0253 0.3317 0.5776
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0542 0.0569
Mycobacterium tuberculosis Conserved protein 0.007 0.0722 0.1109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0425 0.5743 0.5741
Onchocerca volvulus 0.0079 0.0856 0.0804
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0057 0.0542 0.2862
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0138 0.1686 0.1683
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0057 0.0542 0.0289
Plasmodium vivax unspecified product 0.0025 0.0083 0.0223
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0477 0.1437
Plasmodium vivax 6-phosphofructokinase, putative 0.0057 0.0542 0.3021
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0057 0.0173
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0083 0.0223
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0057 0.0542 0.2621
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0542 0.0569
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0083 0.0083
Brugia malayi phosphofructokinase 0.0212 0.2727 0.2727
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0141 0.0138
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0057 0.0211
Brugia malayi mbt repeat family protein 0.0047 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0352 0.4714 0.4712
Entamoeba histolytica cysteine protease, putative 0.0025 0.0083 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0046 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0543 0.057
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0477 0.2457
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0457 0.0457
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.011 0.1285 0.2238
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0556 0.0553
Brugia malayi cathepsin L-like precursor 0.0057 0.0543 0.0543
Schistosoma mansoni cathepsin C 0.0025 0.0083 0.008
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.2069 0.2024
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0083 0.0095
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0071 0.073 0.0727
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0253 0.3317 0.3315
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.073 0.1271
Loa Loa (eye worm) hypothetical protein 0.007 0.0722 0.0722
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0477 0.0474
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Entamoeba histolytica hypothetical protein, conserved 0.0071 0.073 0.2519
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.073 0.073
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0722 0.2178
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0477 0.083
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0079 0.0856 0.0856
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0542 0.0808
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0057 0.0542 0.1419
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0057 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0057 0.0211
Leishmania major hypothetical protein, conserved 0.007 0.0722 0.2178
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0376 0.0373
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Schistosoma mansoni ap endonuclease 0.0057 0.0542 0.054
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0083 0.008
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0543 0.0543
Onchocerca volvulus 0.007 0.0722 0.0669
Echinococcus multilocularis fk506 binding protein 0.0053 0.0477 0.0474
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0057 0.0211
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0391 0.0388
Entamoeba histolytica hypothetical protein 0.0025 0.0083 0.0095
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0542 0.1634
Onchocerca volvulus Prolyl endopeptidase homolog 0.0191 0.2428 0.2384
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0376 0.0373
Onchocerca volvulus 0.0051 0.0457 0.0402
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Brugia malayi mbt repeat family protein 0.0047 0.0391 0.0391
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0722 0.1109
Echinococcus granulosus cathepsin l1 0.0057 0.0543 0.054
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0046 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0722 0.072
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0083
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0083 0.0223
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0057
Plasmodium vivax vivapain-2 0.0079 0.0856 0.4941
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0856 0.1491
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0856 0.0854
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0057 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0722 0.1109
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0057 0.0173
Entamoeba histolytica prolyl oligopeptidase family protein 0.0071 0.073 0.2519
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0391 0.0388
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0083 0.008
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0856 0.0854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0083 0.0223
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0543 0.054
Echinococcus multilocularis cathepsin L 0.0047 0.0396 0.0394
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0057 0.0542 0.0569
Onchocerca volvulus 0.0079 0.0856 0.0804
Mycobacterium tuberculosis Conserved protein 0.007 0.0722 0.1109
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.012 0.1431 0.229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0083 0.0223
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0396 0.069
Loa Loa (eye worm) prolyl oligopeptidase 0.0726 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0477 0.1748
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0253 0.3317 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0191 0.2428 0.2426
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0425 0.5743 0.5741
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0722 0.1109
Echinococcus granulosus cathepsin L 0.0025 0.0083 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2195 0.2619
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0477 0.0477
Brugia malayi prolyl oligopeptidase family protein 0.0191 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.0071 0.073 0.073
Mycobacterium ulcerans lipase LipD 0.007 0.0722 0.2649
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0045 0.0376 0.0376
Echinococcus granulosus Dipeptidyl peptidase 9 0.0253 0.3317 0.3315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0361 0.0358
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0396 0.0394
Trypanosoma cruzi oligopeptidase b 0.011 0.1285 0.2238
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.1833 0.1831
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0722 0.0793
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0396 0.069
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0374 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0057 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0057 0.0211
Loa Loa (eye worm) hypothetical protein 0.0057 0.0543 0.0543
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Giardia lamblia Alanyl dipeptidyl peptidase 0.0071 0.073 0.3695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Brugia malayi cathepsin L precursor 0.0025 0.0083 0.0083
Echinococcus multilocularis cathepsin b 0.0425 0.5743 0.5741
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Loa Loa (eye worm) hypothetical protein 0.007 0.0722 0.0722
Onchocerca volvulus 0.0079 0.0856 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0856 0.0959
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0542 0.1634
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0722 0.0793
Toxoplasma gondii exonuclease III APE 0.0057 0.0542 0.142
Leishmania major cathepsin L-like protease 0.0079 0.0856 0.2582
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0396 0.1956
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0141 0.0138
Onchocerca volvulus 0.007 0.0722 0.0669
Plasmodium vivax vivapain-1 0.0047 0.0396 0.2136
Onchocerca volvulus 0.0161 0.2003 0.1957
Trichomonas vaginalis esterase, putative 0.007 0.0722 0.0793
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0071 0.073 0.2519
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0083 0.0083
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.011 0.1285 0.4599
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0376 0.0373
Schistosoma mansoni hypothetical protein 0.0294 0.3895 0.3893
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0126 0.0123
Loa Loa (eye worm) hypothetical protein 0.0071 0.073 0.073
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0079 0.0856 0.4826
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0542 0.0944
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0083 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0396 0.127
Schistosoma mansoni hypothetical protein 0.002 0.0017 0.0015
Toxoplasma gondii cathepsin B 0.0149 0.1833 0.5413
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0722 0.0793
Schistosoma mansoni ap endonuclease 0.0057 0.0542 0.054
Echinococcus granulosus GPI anchor transamidase 0.0138 0.1686 0.1683
Trichomonas vaginalis phosphofructokinase, putative 0.0212 0.2727 0.3278
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0542 0.0569
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0138 0.1686 0.5082
Onchocerca volvulus Legumain homolog 0.0595 0.8149 0.8138
Onchocerca volvulus 0.0079 0.0856 0.0804
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0057
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Echinococcus multilocularis cathepsin L 0.0025 0.0083 0.008
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0477 0.225
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0044 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0856 0.2993
Schistosoma mansoni bromodomain containing protein 0.0062 0.0605 0.0603
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0722 0.2649
Plasmodium vivax 6-phosphofructokinase, putative 0.0057 0.0542 0.3021
Toxoplasma gondii cathepsin CPL 0.0079 0.0856 0.2392
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0856 0.0959
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0856 0.0856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0856 0.0959
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0556 0.0553
Onchocerca volvulus 0.0079 0.0856 0.0804
Plasmodium falciparum peptidase, putative 0.0071 0.073 0.4036
Onchocerca volvulus 0.0057 0.0543 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0361 0.0358
Loa Loa (eye worm) 6-phosphofructokinase 0.0212 0.2727 0.2727
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0482 0.0482
Loa Loa (eye worm) fibroinase 0.0079 0.0856 0.0856
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0057 0.0542 0.5
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0391 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3294 0.3981
Leishmania major oligopeptidase b 0.011 0.1285 0.3875
Loa Loa (eye worm) hypothetical protein 0.0425 0.5743 0.5743
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0083 0.0223
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0477 0.1437
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0069 0.0708 0.0708
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0396 0.069
Schistosoma mansoni cathepsin s 0.0022 0.0046 0.0044
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0595 0.8149 1
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0722 0.1109
Toxoplasma gondii 6-phosphofructokinase 0.0057 0.0542 0.1419
Mycobacterium ulcerans 6-phosphofructokinase 0.0212 0.2727 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0477 0.2625
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0017 0.0017
Brugia malayi beta-lactamase 0.007 0.0722 0.0722
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0083 0.0223
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0071 0.073 0.0802
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0083 0.0083
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0079 0.0856 0.4826
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0542 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.073 0.1271
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0542 0.0569
Mycobacterium ulcerans beta-lactamase 0.007 0.0722 0.2649
Echinococcus granulosus 6 phosphofructokinase 0.0212 0.2727 0.2725
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0262
Echinococcus granulosus cathepsin L 0.0047 0.0396 0.0394
Loa Loa (eye worm) hypothetical protein 0.0053 0.0482 0.0482
Loa Loa (eye worm) cathepsin B 0.0149 0.1833 0.1833
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0083 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0212 0.2727 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.232 0.232
Schistosoma mansoni 6-phosphofructokinase 0.0212 0.2727 0.2725
Echinococcus granulosus prolyl endopeptidase 0.0191 0.2428 0.2426
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0253 0.3317 1
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0856 0.1491
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0253 0.3317 1
Toxoplasma gondii hypothetical protein 0.0071 0.073 0.2
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Brugia malayi Cathepsin L-like precursor 0.0079 0.0856 0.0856
Plasmodium vivax hypothetical protein, conserved 0.0071 0.073 0.4169
Entamoeba histolytica cysteine protease, putative 0.0025 0.0083 0.0095
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0191 0.2428 0.2426
Echinococcus granulosus cathepsin l1 0.0079 0.0856 0.0854
Entamoeba histolytica cysteine protease, putative 0.0047 0.0396 0.127
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0595 0.8149 0.8149
Echinococcus multilocularis geminin 0.0352 0.4714 0.4712
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2069 0.2463
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0396 0.069
Onchocerca volvulus 0.0029 0.0141 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0071 0.073 0.22
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0543 0.1818
Echinococcus granulosus cathepsin l cysteine peptidase 0.0079 0.0856 0.0854
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0477 0.0488
Giardia lamblia Cathepsin B precursor 0.0149 0.1833 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1686 0.1686
Echinococcus multilocularis cysteine protease 0.0079 0.0856 0.0854
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0083 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0856 0.0959
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0482 0.0479
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0856 0.2582
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0726 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0228 0.0226
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0726 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0543 0.057
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0722 0.0793
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0057 0.0211
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0542 0.0944
Echinococcus multilocularis GPI anchor transamidase 0.0138 0.1686 0.1683
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0071 0.073 0.2519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0396 0.0389
Loa Loa (eye worm) MBCTL1 0.0053 0.0482 0.0482
Brugia malayi Cathepsin L-like precursor 0.0079 0.0856 0.0856
Mycobacterium tuberculosis Probable peptidase 0.011 0.1285 0.2047
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0044 0.0041
Brugia malayi GPI-anchor transamidase 0.0138 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.004 0.0295 0.0295
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.011 0.1285 0.2238
Entamoeba histolytica cysteine protease, putative 0.0025 0.0083 0.0095
Schistosoma mansoni hypothetical protein 0.0457 0.6196 0.6195
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0856 0.0856
Echinococcus granulosus cathepsin b 0.0425 0.5743 0.5741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0396 0.0389
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0542 0.2623

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4609 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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