Detailed information for compound 1306229

Basic information

Technical information
  • TDR Targets ID: 1306229
  • Name: N-(furan-2-ylmethyl)-6-oxopyran-3-carboxamide
  • MW: 219.193 | Formula: C11H9NO4
  • H donors: 1 H acceptors: 2 LogP: 0.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc(co1)C(=O)NCc1ccco1
  • InChi: 1S/C11H9NO4/c13-10-4-3-8(7-16-10)11(14)12-6-9-2-1-5-15-9/h1-5,7H,6H2,(H,12,14)
  • InChiKey: FMGIKUUNEULXBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-furylmethyl)-6-oxo-pyran-3-carboxamide
  • N-(2-furylmethyl)-6-oxo-3-pyrancarboxamide
  • N-(2-furylmethyl)-6-keto-pyran-3-carboxamide
  • N-(furan-2-ylmethyl)-6-oxo-pyran-3-carboxamide
  • STOCK2S-72843
  • MLS000078347
  • SMR000037656
  • ZINC00545945

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni patched 1 0.0215 0.0324 0.0789
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0123 0.0647
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.0123 0.2572
Echinococcus granulosus Protein son of sevenless 0.0033 0.0017 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0041 0.2207
Mycobacterium tuberculosis Carboxylesterase LipT 0.0069 0.0078 0.1409
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0027 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0023 0.012
Schistosoma mansoni myst-related protein 0.0024 0.0003 0.0007
Trypanosoma cruzi cysteine protease, putative 0.0622 0.101 0.2777
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0031 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0031 0.0086
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.0041 0.0291
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0017 0.0017
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0023 0.0063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0027 0.0141
Schistosoma mansoni DNA ligase IV 0.005 0.0047 0.0113
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Toxoplasma gondii cathepsin CPC2 0.0261 0.0402 0.2113
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0307 0.048 0.892
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0327 0.0513 0.141
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0205 0.0308 0.0847
Giardia lamblia Cathepsin L-like protease 0.0261 0.0402 0.2865
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0009 0.0026
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0047 0.0245
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0027 0.0141
Loa Loa (eye worm) MH1 domain-containing protein 0.0031 0.0015 0.0041
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.009 0.009
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0622 0.101 0.2458
Trypanosoma cruzi cysteine proteinase, putative 0.0622 0.101 0.2777
Echinococcus granulosus Niemann Pick C1 protein 0.0501 0.0806 0.1961
Echinococcus multilocularis snurportin 1 0.0325 0.051 0.051
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0017 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0221 0.0334 0.0812
Brugia malayi Thioredoxin reductase 0.0135 0.0189 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0261 0.0402 0.2113
Schistosoma mansoni hypothetical protein 0.026 0.04 0.0974
Entamoeba histolytica hypothetical protein 0.0195 0.029 0.1525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0031 0.0086
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0041 0.0099
Brugia malayi Cathepsin L-like precursor 0.0791 0.1294 0.3557
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0195 0.029 0.0798
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0041 0.0213
Onchocerca volvulus 0.003 0.0013 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0791 0.1294 0.6802
Loa Loa (eye worm) transcription factor SMAD2 0.1024 0.1687 0.4636
Brugia malayi hypothetical protein 0.0069 0.0078 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.1152 0.1903 0.5229
Loa Loa (eye worm) hypothetical protein 0.0361 0.0571 0.1568
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0822 0.1346 0.3701
Echinococcus granulosus Protein patched homolog 1 0.0215 0.0324 0.0789
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1152 0.1903 0.5229
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0004 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0031 0.0086
Entamoeba histolytica cysteine protease, putative 0.0261 0.0402 0.2113
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0031 0.0076
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0031 0.0076
Giardia lamblia Cathepsin B precursor 0.0261 0.0402 0.2865
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0261 0.0402 0.2113
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0028 0.0203
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0047
Echinococcus granulosus GPCR family 2 0.026 0.04 0.0974
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0047 0.0245
Echinococcus multilocularis sterol regulatory element binding protein 0.0215 0.0324 0.0324
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Onchocerca volvulus 0.0051 0.0048 0.0204
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0023 0.0063
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0031 0.0076
Loa Loa (eye worm) patched family protein 0.003 0.0013 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0562 0.0908 0.2497
Onchocerca volvulus 0.0791 0.1294 0.6786
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0064 0.0069 0.0069
Echinococcus granulosus carboxylesterase 5A 0.0407 0.0649 0.1578
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0031 0.0076
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0046 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Echinococcus multilocularis dnaJ subfamily B 0.2462 0.411 0.411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0031 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0031 0.0076
Brugia malayi Patched related family protein 10 0.003 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0261 0.0402 0.2113
Onchocerca volvulus 0.1152 0.1903 1
Brugia malayi Papain family cysteine protease containing protein 0.0261 0.0402 0.1105
Toxoplasma gondii patched family protein 0.003 0.0013 0.007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0201 0.0489
Onchocerca volvulus 0.0046 0.0039 0.0158
Echinococcus multilocularis segment polarity protein dishevelled 0.0046 0.0039 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0622 0.101 0.531
Loa Loa (eye worm) hypothetical protein 0.0076 0.009 0.0248
Echinococcus granulosus thioredoxin glutathione reductase 0.0135 0.019 0.0462
Brugia malayi Cathepsin L-like precursor 0.1152 0.1903 0.5229
Echinococcus multilocularis cathepsin L cysteine protease 0.1152 0.1903 0.1903
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0261 0.0402 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0047 0.0245
Giardia lamblia Cathepsin B precursor 0.0855 0.1403 1
Trypanosoma cruzi cysteine peptidase, putative 0.0622 0.101 0.2777
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.0123 0.2248
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0128
Leishmania major trypanothione reductase 0.0135 0.0189 0.0994
Plasmodium vivax unspecified product 0.0622 0.101 0.531
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0041
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0069 0.0078 0.0411
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Trichomonas vaginalis helicase, putative 0.0047 0.0041 0.0213
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0027 0.0065
Onchocerca volvulus 0.005 0.0047 0.0196
Loa Loa (eye worm) glutathione reductase 0.0135 0.0189 0.052
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0208 0.0208
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0261 0.0402 0.2113
Brugia malayi Carboxylesterase family protein 0.0069 0.0078 0.0215
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0261 0.0402 0.0978
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0069 0.0078 0.019
Echinococcus multilocularis cathepsin L cysteine protease 0.1152 0.1903 0.1903
Giardia lamblia Encystation-specific protease 0.0261 0.0402 0.2865
Loa Loa (eye worm) MH1 domain-containing protein 0.007 0.008 0.0219
Plasmodium falciparum zinc finger protein, putative 0.0024 0.0003 0.0016
Echinococcus granulosus segment polarity protein dishevelled 0.0046 0.0039 0.0096
Entamoeba histolytica cysteine protease, putative 0.0261 0.0402 0.2113
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.0324 0.1705
Echinococcus multilocularis segment polarity protein dishevelled 0.0046 0.0039 0.0039
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0208 0.0571
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0027 0.0191
Brugia malayi hypothetical protein 0.0221 0.0334 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0082 0.0226
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0509 0.0819 0.1993
Brugia malayi hypothetical protein 0.005 0.0047 0.0128
Echinococcus granulosus BC026374 protein S09 family 0.0069 0.0078 0.019
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Schistosoma mansoni smad1 5 8 and 0.007 0.008 0.0194
Onchocerca volvulus 0.0151 0.0216 0.109
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 0.1829
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Echinococcus multilocularis regulator of G protein signaling 7 0.0046 0.0039 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0027 0.0394
Giardia lamblia Hypothetical protein 0.0261 0.0402 0.2865
Echinococcus multilocularis nibrin 0.005 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0031 0.0031
Entamoeba histolytica cysteine proteinase, putative 0.0622 0.101 0.531
Loa Loa (eye worm) acetylcholinesterase 1 0.0407 0.0649 0.1783
Schistosoma mansoni coup transcription factor 0.0041 0.0031 0.0076
Entamoeba histolytica hypothetical protein 0.005 0.0047 0.0245
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0261 0.0402 0.0978
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0023 0.0063
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0017 0.004
Echinococcus multilocularis neuroligin 0.0069 0.0078 0.0078
Plasmodium vivax vivapain-3 0.0622 0.101 0.531
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2182 0.3638 0.8852
Schistosoma mansoni hypothetical protein 0.026 0.04 0.0974
Plasmodium vivax replication factor C subunit 1, putative 0.005 0.0047 0.0245
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0407 0.0649 0.1578
Toxoplasma gondii histone lysine methyltransferase SET1 0.0392 0.0623 0.3276
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0261 0.0402 0.2113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Entamoeba histolytica hypothetical protein 0.0024 0.0003 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0123 0.0647
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0041 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0123
Entamoeba histolytica hypothetical protein 0.0025 0.0004 0.002
Echinococcus granulosus smad 0.007 0.008 0.0194
Brugia malayi CHE-14 protein 0.0215 0.0324 0.0891
Schistosoma mansoni hypothetical protein 0.0051 0.0048 0.0117
Schistosoma mansoni smad1 5 8 and 0.007 0.008 0.0194
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.026 0.04 0.0974
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0047 0.0128
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Plasmodium falciparum serine repeat antigen 4 0.0261 0.0402 0.2113
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0261 0.0402 0.2865
Onchocerca volvulus 0.0069 0.0078 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0327 0.0513 0.1248
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0195 0.029 0.0798
Loa Loa (eye worm) hypothetical protein 0.0071 0.0082 0.0226
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0009 0.0123
Entamoeba histolytica hypothetical protein 0.0033 0.0017 0.009
Echinococcus granulosus cathepsin L cysteine protease 0.0622 0.101 0.2458
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0261 0.0402 0.2113
Brugia malayi protein C24B5.3 0.003 0.0013 0.0037
Echinococcus multilocularis acetylcholinesterase 0.0407 0.0649 0.0649
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0031 0.0115
Plasmodium falciparum serine repeat antigen 9 0.0261 0.0402 0.2113
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0123 0.2572
Loa Loa (eye worm) patched family protein 0.003 0.0013 0.0037
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0261 0.0402 0.2113
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0023 0.0055
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0004 0.0011
Plasmodium falciparum serine repeat antigen 5 0.0261 0.0402 0.2113
Loa Loa (eye worm) hypothetical protein 0.093 0.1529 0.4202
Trypanosoma brucei trypanothione reductase 0.0135 0.0189 0.0994
Echinococcus multilocularis son of sevenless 1 0.0033 0.0017 0.0017
Brugia malayi Smad1 0.007 0.008 0.0219
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0622 0.101 0.2777
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.0123 0.2572
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0041 0.0213
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0023 0.0055
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0208 0.0506
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0031 0.0076
Echinococcus multilocularis carboxylesterase 5A 0.0407 0.0649 0.0649
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0041 0.071
Schistosoma mansoni ap endonuclease 0.0038 0.0027 0.0065
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0023 0.0055
Toxoplasma gondii ATPase, AAA family protein 0.005 0.0047 0.0245
Toxoplasma gondii preprocathepsin c precursor, putative 0.0261 0.0402 0.2113
Trichomonas vaginalis spcc417.12 protein, putative 0.0069 0.0078 0.0411
Schistosoma mansoni hypothetical protein 0.2462 0.411 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.002 0.0055
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0004 0.002
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.0722 0.0722
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0327 0.0513 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0791 0.1294 0.6802
Loa Loa (eye worm) hypothetical protein 0.0361 0.0571 0.1568
Loa Loa (eye worm) hypothetical protein 0.0261 0.0402 0.1105
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0123 0.0647
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0041 0.0215
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Schistosoma mansoni topbp1 0.005 0.0047 0.0113
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0005 0.0026
Schistosoma mansoni hypothetical protein 0.0721 0.1177 0.2863
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0435 0.0696 0.1692
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0031 0.0076
Trichomonas vaginalis ras GTP exchange factor, putative 0.0033 0.0017 0.009
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0009 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Brugia malayi Papain family cysteine protease containing protein 0.0261 0.0402 0.1105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Giardia lamblia Cysteine protease 0.0261 0.0402 0.2865
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0017 0.0087
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.029 0.0451 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0046 0.0039 0.0108
Giardia lamblia Cathepsin B precursor 0.0261 0.0402 0.2865
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0307 0.048 0.892
Loa Loa (eye worm) hypothetical protein 0.0071 0.0082 0.0226
Loa Loa (eye worm) MH2 domain-containing protein 0.007 0.008 0.0219
Loa Loa (eye worm) hypothetical protein 0.0261 0.0402 0.1105
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0031 0.0086
Brugia malayi N-terminal motif family protein 0.0033 0.0017 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1152 0.1903 1
Onchocerca volvulus 0.1152 0.1903 1
Echinococcus multilocularis replication factor c subunit 1 0.005 0.0047 0.0047
Brugia malayi Cathepsin L-like precursor 0.1152 0.1903 0.5229
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0112
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0014 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0327 0.0513 0.0513
Brugia malayi MH1 domain containing protein 0.0039 0.0027 0.0075
Brugia malayi Carboxylesterase family protein 0.0407 0.0649 0.1783
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0017 0.0087
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0622 0.101 0.2458
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1152 0.1903 0.1903
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0031 0.0086
Echinococcus multilocularis mothers against decapentaplegic 2 0.0031 0.0015 0.0015
Onchocerca volvulus Cathepsin F homolog 0.1152 0.1903 1
Echinococcus multilocularis cathepsin b 0.2182 0.3638 0.3638
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Loa Loa (eye worm) acetyltransferase 0.0146 0.0208 0.0571
Loa Loa (eye worm) cathepsin B 0.0855 0.1403 0.3856
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0215
Brugia malayi cathepsin L-like precursor 0.0791 0.1294 0.3557
Echinococcus multilocularis tar DNA binding protein 0.0457 0.0733 0.0733
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.026 0.04 0.04
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0112
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.051 0.1402
Schistosoma mansoni smad 0.0031 0.0015 0.0036
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 0.0474
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0341 0.0537 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0017 0.0046
Plasmodium vivax unspecified product 0.0261 0.0402 0.2113
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0017 0.0087
Onchocerca volvulus 0.0095 0.0123 0.06
Onchocerca volvulus 0.1152 0.1903 1
Echinococcus multilocularis cathepsin L 0.0261 0.0402 0.0402
Brugia malayi Cathepsin L-like precursor 0.1152 0.1903 0.5229
Entamoeba histolytica cysteine proteinase, putative 0.0791 0.1294 0.6802
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0261 0.0402 0.0978
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0261 0.0402 0.2113
Onchocerca volvulus 0.1152 0.1903 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Echinococcus multilocularis GPCR, family 2 0.026 0.04 0.04
Loa Loa (eye worm) latrophilin receptor protein 2 0.026 0.04 0.11
Loa Loa (eye worm) hypothetical protein 0.0501 0.0806 0.2215
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0501 0.0806 0.4236
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Brugia malayi Niemann-Pick C1 protein precursor 0.0501 0.0806 0.2215
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.009 0.0474
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0123 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0031 0.0086
Schistosoma mansoni importin beta-1 0.003 0.0014 0.0033
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0855 0.1403 0.3856
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0031 0.0086
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0046 0.0039 0.0108
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0009 0.0026
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0017 0.004
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Loa Loa (eye worm) patched family protein 0.003 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0261 0.0402 0.2113
Schistosoma mansoni Smad4 0.0031 0.0015 0.0036
Schistosoma mansoni dishevelled 0.0046 0.0039 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Echinococcus multilocularis cathepsin b 0.2182 0.3638 0.3638
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0026
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0041 0.0215
Onchocerca volvulus Cathepsin L homolog 0.0261 0.0402 0.2073
Plasmodium falciparum serine repeat antigen 8 0.0261 0.0402 0.2113
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0031 0.0115
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0128
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0009 0.0123
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0261 0.0402 0.1105
Brugia malayi cathepsin F-like cysteine proteinase 0.0261 0.0402 0.1105
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0261 0.0402 0.1105
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0009 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0261 0.0402 0.2113
Loa Loa (eye worm) carboxylesterase 0.0069 0.0078 0.0215
Plasmodium falciparum thioredoxin reductase 0.0047 0.0041 0.0215
Trichomonas vaginalis replication factor C large subunit, putative 0.005 0.0047 0.0245
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0031 0.0086
Schistosoma mansoni hypothetical protein 0.026 0.04 0.0974
Brugia malayi RNA binding protein 0.0457 0.0733 0.2014
Schistosoma mansoni ras GTP exchange factor 0.0033 0.0017 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0041 0.0213
Brugia malayi MH2 domain containing protein 0.007 0.008 0.0219
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0031 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Giardia lamblia Cathepsin B precursor 0.0855 0.1403 1
Loa Loa (eye worm) TAR-binding protein 0.0457 0.0733 0.2014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1152 0.1903 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0034 0.0181
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0215 0.0324 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Onchocerca volvulus 0.0033 0.0017 0.0041
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0261 0.0402 0.2113
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0031 0.0031
Echinococcus granulosus cathepsin l1 0.0791 0.1294 0.3149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.0513 0.1248
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0261 0.0402 0.2113
Loa Loa (eye worm) oxidoreductase 0.0028 0.0009 0.0026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0006 0.0033
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0195 0.029 0.1525
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0123 0.2248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.0513 0.1248
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0034 0.0181
Schistosoma mansoni cpg binding protein 0.0217 0.0328 0.0797
Loa Loa (eye worm) hypothetical protein 0.0194 0.0289 0.0793
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0307 0.048 0.892
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.007 0.008 0.0194
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.009 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0031 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0622 0.101 0.2777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0041 0.0215
Entamoeba histolytica protein kinase, putative 0.0195 0.029 0.1525
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Trypanosoma cruzi cruzipain precursor, putative 0.0361 0.0571 0.1568
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.026 0.04 0.11
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Trypanosoma cruzi hypothetical protein 0.0033 0.0017 0.0047
Echinococcus granulosus mothers against decapentaplegic 2 0.0031 0.0015 0.0036
Plasmodium vivax vivapain-1 0.0622 0.101 0.531
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0031 0.0086
Plasmodium vivax vivapain-2 0.1152 0.1903 1
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0031 0.0086
Trypanosoma cruzi FHA domain containing protein, putative 0.005 0.0047 0.0128
Onchocerca volvulus 0.0069 0.0078 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0041 0.0213
Brugia malayi F/Y-rich N-terminus family protein 0.0063 0.0068 0.0186
Plasmodium falciparum glutathione reductase 0.0135 0.0189 0.0994
Loa Loa (eye worm) RasGEF domain-containing protein 0.0033 0.0017 0.0047
Echinococcus granulosus dual specificity 0.0195 0.029 0.0706
Mycobacterium tuberculosis Probable oxidoreductase 0.0341 0.0537 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0027 0.0074
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0041 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Brugia malayi steroid hormone receptor 0.0041 0.0031 0.0086
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.1152 0.1903 0.5229
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Schistosoma mansoni hypothetical protein 0.0207 0.0311 0.0757
Brugia malayi Latrophilin receptor protein 2 0.026 0.04 0.11
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Plasmodium falciparum replication factor C subunit 1, putative 0.005 0.0047 0.0245
Brugia malayi nuclear receptor NHR-88 0.0041 0.0031 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0123 0.2572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0361 0.0571 0.1568
Loa Loa (eye worm) carboxylesterase 0.0407 0.0649 0.1783
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0031 0.0014 0.0035
Echinococcus multilocularis BC026374 protein (S09 family) 0.0069 0.0078 0.0078
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0009 0.0123
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0051 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Echinococcus multilocularis Protein son of sevenless 0.0033 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0046 0.0039 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Loa Loa (eye worm) glutaminase 0.0282 0.0437 0.1201
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0791 0.1294 0.3149
Plasmodium falciparum acyl-CoA synthetase 0.0071 0.0082 0.0433
Entamoeba histolytica cysteine proteinase, putative 0.1152 0.1903 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.007 0.008 0.0194
Echinococcus multilocularis protein dispatched 1 0.0245 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0622 0.101 0.531
Loa Loa (eye worm) RasGEF domain-containing protein 0.0033 0.0017 0.0047
Brugia malayi TAR-binding protein 0.0457 0.0733 0.2014
Brugia malayi cathepsin Z-like cysteine proteinase 0.0261 0.0402 0.1105
Echinococcus granulosus replication factor c subunit 1 0.005 0.0047 0.0113
Echinococcus granulosus cathepsin L 0.0622 0.101 0.2458
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Schistosoma mansoni smad 0.007 0.008 0.0194
Brugia malayi hypothetical protein 0.005 0.0047 0.0128
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0034 0.0181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Entamoeba histolytica cysteine protease, putative 0.0261 0.0402 0.2113
Echinococcus multilocularis mothers against decapentaplegic 5 0.007 0.008 0.008
Echinococcus granulosus mothers against decapentaplegic 5 0.007 0.008 0.0194
Brugia malayi Patched protein homolog 1 0.003 0.0013 0.0037
Onchocerca volvulus Cathepsin L homolog 0.1152 0.1903 1
Echinococcus multilocularis protein patched 0.0215 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0215 0.0324 0.0891
Plasmodium vivax patched family protein, putative 0.003 0.0013 0.007
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Schistosoma mansoni dishevelled 0.0046 0.0039 0.0096
Brugia malayi RNA, U transporter 1 0.0087 0.0108 0.0297
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.005 0.0047 0.0128
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0361 0.0571 0.1568
Brugia malayi fibroinase precursor 0.0261 0.0402 0.1105
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0261 0.0402 0.0978
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0047 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0006 0.0033
Onchocerca volvulus 0.0069 0.0078 0.0363
Schistosoma mansoni z-protein (S1r protein) 0.0046 0.0039 0.0096
Brugia malayi Cathepsin L-like precursor 0.0791 0.1294 0.3557
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.0123 0.0647
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0046 0.0809
Brugia malayi Papain family cysteine protease containing protein 0.0622 0.101 0.2777
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0033 0.0017 0.0042
Schistosoma mansoni ap endonuclease 0.0038 0.0027 0.0065
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0023 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0457 0.0733 0.1783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0123 0.0338
Schistosoma mansoni hypothetical protein 0.026 0.04 0.0974
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0221 0.0334 0.0334
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2182 0.3638 0.8852
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0123 0.2572
Plasmodium falciparum serine repeat antigen 6 0.0261 0.0402 0.2113
Echinococcus granulosus mothers against decapentaplegic 6 0.0031 0.0015 0.0036
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Schistosoma mansoni tar DNA-binding protein 0.0457 0.0733 0.1783
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Entamoeba histolytica cysteine proteinase, putative 0.1152 0.1903 1
Echinococcus multilocularis cysteine protease 0.1152 0.1903 0.1903
Brugia malayi Papain family cysteine protease containing protein 0.1152 0.1903 0.5229
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0047 0.0245
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0622 0.101 0.531
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0031 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0027 0.0141
Onchocerca volvulus 0.0041 0.0031 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0261 0.0402 0.2113
Loa Loa (eye worm) nuclear factor I 0.0039 0.0027 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Echinococcus granulosus neuroligin 0.0069 0.0078 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0027 0.0141
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0031 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0123 0.0338
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0135 0.0189 0.3483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0261 0.0402 0.2113
Onchocerca volvulus Protein patched homolog 0.003 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.026 0.04 0.11
Schistosoma mansoni hypothetical protein 0.0721 0.1177 0.2863
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.026 0.04 0.04
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0023 0.012
Onchocerca volvulus 0.0069 0.0078 0.0363
Toxoplasma gondii patched family protein 0.003 0.0013 0.007
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Echinococcus granulosus cathepsin l cysteine peptidase 0.1152 0.1903 0.4629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Onchocerca volvulus 0.0468 0.0751 0.3916
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0261 0.0402 0.2113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0361 0.0571 0.1568
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.009 0.0474
Loa Loa (eye worm) RasGEF domain-containing protein 0.0033 0.0017 0.0047
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0047 0.0245
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0027 0.0141
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0017 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0261 0.0402 0.1105
Brugia malayi Patched related family protein 4 0.003 0.0013 0.0037
Brugia malayi Protein kinase domain containing protein 0.0195 0.029 0.0798
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0017 0.0017
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0261 0.0402 0.2865
Echinococcus granulosus neuropeptide s receptor 0.0451 0.0722 0.1757
Loa Loa (eye worm) hypothetical protein 0.0046 0.0039 0.0108
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.0407 0.0649 0.1783
Onchocerca volvulus 0.1152 0.1903 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0041 0.0213
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0017 0.0087
Loa Loa (eye worm) patched family protein 0.003 0.0013 0.0037
Brugia malayi hypothetical protein 0.003 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0009 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0457 0.0733 0.1783
Brugia malayi photoreceptor-specific nuclear receptor 0.0284 0.0441 0.1212
Echinococcus granulosus expressed conserved protein 0.0471 0.0755 0.1836
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi MH2 domain containing protein 0.0031 0.0015 0.0041
Loa Loa (eye worm) ctsf protein 0.1152 0.1903 0.5229
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Schistosoma mansoni cathepsin F (C01 family) 0.1152 0.1903 0.4629
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0009 0.0026
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0017 0.0087
Echinococcus granulosus cathepsin L 0.0261 0.0402 0.0978
Brugia malayi Myosin head containing protein 0.003 0.0013 0.0037
Toxoplasma gondii thioredoxin reductase 0.0135 0.0189 0.0994
Brugia malayi RasGEF domain containing protein 0.0033 0.0017 0.0047
Toxoplasma gondii patched family protein 0.003 0.0013 0.007
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0017 0.0087
Plasmodium falciparum serine repeat antigen 7 0.0261 0.0402 0.2113
Entamoeba histolytica cysteine proteinase 1, putative 0.0622 0.101 0.531
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0041 0.0215
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0014
Echinococcus multilocularis Niemann Pick C1 protein 0.0501 0.0806 0.0806
Loa Loa (eye worm) hypothetical protein 0.0261 0.0402 0.1105
Leishmania major cathepsin L-like protease 0.1152 0.1903 1
Brugia malayi nuclear hormone receptor 0.0041 0.0031 0.0086
Loa Loa (eye worm) histone methyltransferase 0.0064 0.0069 0.019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0383 0.0932
Giardia lamblia Hypothetical protein 0.0261 0.0402 0.2865
Trypanosoma cruzi hypothetical protein 0.0033 0.0017 0.0047
Loa Loa (eye worm) Smad1 0.007 0.008 0.0219
Entamoeba histolytica hypothetical protein 0.0261 0.0402 0.2113
Schistosoma mansoni cathepsin B (C01 family) 0.0261 0.0402 0.0978
Schistosoma mansoni transcription factor LCR-F1 0.0221 0.0334 0.0812
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0009 0.0026
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0047 0.0128
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0009 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0031 0.0086
Echinococcus granulosus Smad4 0.007 0.008 0.0194
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi Pax transcription activation domain interacting protein 0.005 0.0047 0.0128
Toxoplasma gondii exonuclease III APE 0.0038 0.0027 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0112
Trichomonas vaginalis hypothetical protein 0.0025 0.0004 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.1024 0.1687 0.4636
Brugia malayi isocitrate dehydrogenase 0.0032 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0151 0.0216 0.0593
Brugia malayi hypothetical protein 0.003 0.0013 0.0037
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0046 0.0039 0.0158
Loa Loa (eye worm) hypothetical protein 0.0284 0.0441 0.1212
Brugia malayi Cathepsin L-like precursor 0.1152 0.1903 0.5229
Onchocerca volvulus 0.0261 0.0402 0.2073
Plasmodium falciparum serine repeat antigen 1 0.0261 0.0402 0.2113
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0327 0.0513 0.141
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0046 0.0039 0.0108
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0128
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0009 0.0123
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0341 0.0537 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0031 0.0086
Echinococcus multilocularis expressed conserved protein 0.0471 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.026 0.04 0.0974
Plasmodium vivax serine-repeat antigen (SERA) 0.0261 0.0402 0.2113
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0026
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0009 0.0123
Entamoeba histolytica cysteine proteinase, putative 0.0622 0.101 0.531
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0023 0.012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.009 0.0474
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Brugia malayi hypothetical protein 0.0046 0.0039 0.0108
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0261 0.0402 0.2113
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0195 0.029 0.1525
Echinococcus granulosus acetylcholinesterase 0.0407 0.0649 0.1578
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0041 0.0215
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0031 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0051 0.0048 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0041 0.0213
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0026
Mycobacterium tuberculosis Probable reductase 0.0307 0.048 0.892
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0017 0.0042
Echinococcus granulosus cathepsin b 0.2182 0.3638 0.8852
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0457 0.0733 0.2014
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0033 0.0017 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0261 0.0402 0.0978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0261 0.0402 0.2113
Loa Loa (eye worm) hypothetical protein 0.0791 0.1294 0.3557
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.0402 0.2113
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0041 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0046 0.0809
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0078 0.1409
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi MH1 domain containing protein 0.007 0.008 0.0219
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0078 0.019
Giardia lamblia Cysteine protease 0.0261 0.0402 0.2865
Brugia malayi hypothetical protein 0.0025 0.0005 0.0014
Giardia lamblia Cathepsin L precursor 0.0261 0.0402 0.2865
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0034 0.0181
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0048 0.0132
Loa Loa (eye worm) hypothetical protein 0.0071 0.0082 0.0226
Loa Loa (eye worm) glutaminase 2 0.0282 0.0437 0.1201
Echinococcus granulosus cpg binding protein 0.0217 0.0328 0.0797
Onchocerca volvulus 0.003 0.0013 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0031 0.0015 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0031 0.0076
Treponema pallidum DNA ligase (lig) 0.005 0.0047 0.4798
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0012 0.0029
Brugia malayi Carboxylesterase family protein 0.0069 0.0078 0.0215
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0009 0.0023
Schistosoma mansoni myst-related protein 0.0024 0.0003 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Echinococcus multilocularis cysteine protease 0.1152 0.1903 0.1903
Brugia malayi Cathepsin L-like precursor 0.1152 0.1903 0.5229
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0123 0.0338
Mycobacterium tuberculosis Probable dehydrogenase 0.0307 0.048 0.892
Schistosoma mansoni hypothetical protein 0.0207 0.0311 0.0757
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0063
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0261 0.0402 0.2113
Brugia malayi MH2 domain containing protein 0.1024 0.1687 0.4636
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0041 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0046 0.0039 0.0096
Giardia lamblia Cathepsin L precursor 0.0261 0.0402 0.2865
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0261 0.0402 0.2865
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0078 0.019
Loa Loa (eye worm) carboxylesterase 0.0069 0.0078 0.0215
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0017 0.0256
Schistosoma mansoni BC026374 protein (S09 family) 0.0069 0.0078 0.019
Loa Loa (eye worm) hypothetical protein 0.0261 0.0402 0.1105
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0026
Giardia lamblia Cathepsin B precursor 0.0261 0.0402 0.2865
Loa Loa (eye worm) hypothetical protein 0.0263 0.0406 0.1115
Schistosoma mansoni cathepsin s 0.0361 0.0571 0.1388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0034 0.0084
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Onchocerca volvulus 0.0205 0.0308 0.1577
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0014
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.005 0.0047 0.3116
Brugia malayi cathepsin Z-like cysteine proteinase 0.0261 0.0402 0.1105
Loa Loa (eye worm) thioredoxin reductase 0.0135 0.0189 0.052
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0009 0.005
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0261 0.0402 0.2113
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0047 0.0245
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0069 0.0078 0.0078
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0059
Echinococcus multilocularis cathepsin L 0.0622 0.101 0.101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0031 0.0086
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0622 0.101 0.2458
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0033 0.0017 0.0017
Schistosoma mansoni acetylcholinesterase 0.0069 0.0078 0.019
Schistosoma mansoni hypothetical protein 0.0325 0.051 0.1241
Schistosoma mansoni cathepsin C 0.0261 0.0402 0.0978
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0041 0.2207
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Onchocerca volvulus 0.003 0.0013 0.0021
Brugia malayi MH1 domain containing protein 0.007 0.008 0.0219
Loa Loa (eye worm) patched family protein 0.003 0.0013 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0215
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0041 0.0711
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0041 0.0215
Loa Loa (eye worm) hypothetical protein 0.0791 0.1294 0.3557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0261 0.0402 0.2113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0855 0.1403 0.7373
Trypanosoma cruzi major cysteine proteinase, putative 0.0261 0.0402 0.1105
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Brugia malayi topoisomerase 0.005 0.0047 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0076 0.1365
Loa Loa (eye worm) hypothetical protein 0.0407 0.0649 0.1783
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2182 0.3638 0.8852
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0031 0.0086
Brugia malayi Cathepsin L-like cysteine proteinase 0.0791 0.1294 0.3557
Brugia malayi cathepsin L precursor 0.0261 0.0402 0.1105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0261 0.0402 0.0978
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0017 0.0042
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 0.1829
Schistosoma mansoni dep domain containing protein 0.0046 0.0039 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0033 0.0017 0.0042
Echinococcus granulosus para nitrobenzyl esterase 0.0069 0.0078 0.019
Schistosoma mansoni cathepsin S (C01 family) 0.0261 0.0402 0.0978
Entamoeba histolytica cysteine proteinase 2 0.0622 0.101 0.531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0622 0.101 0.531
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Treponema pallidum NADH oxidase 0.0047 0.0041 0.4111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0064 0.0069 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0076 0.1365
Brugia malayi Importin beta-1 subunit 0.003 0.0014 0.0037
Brugia malayi hypothetical protein 0.003 0.0013 0.0037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0031 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.0513 0.1248
Echinococcus multilocularis acetylcholinesterase 0.0407 0.0649 0.0649
Giardia lamblia Cathepsin L-like protease 0.0261 0.0402 0.2865
Schistosoma mansoni cpg binding protein 0.0205 0.0308 0.0749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0261 0.0402 0.2113
Toxoplasma gondii cathepsin CPL 0.1152 0.1903 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0033 0.0017 0.0041
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0027 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0041 0.0215
Plasmodium vivax unspecified product 0.0361 0.0571 0.2999
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0041 0.0215
Loa Loa (eye worm) hypothetical protein 0.0261 0.0402 0.1105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0261 0.0402 0.0978
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0041 0.0711
Echinococcus granulosus Niemann Pick C1 protein 0.0716 0.1168 0.2842
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0261 0.0402 0.2113
Brugia malayi DKFZp564C0469 protein 0.005 0.0047 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0076 0.1365
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0261 0.0402 0.2113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2182 0.3638 0.8852
Echinococcus granulosus segment polarity protein dishevelled 0.0046 0.0039 0.0096
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Echinococcus granulosus ras GTP exchange factor 0.0033 0.0017 0.0042
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0261 0.0402 0.2113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0031 0.0031
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0031 0.0031
Echinococcus multilocularis tumor protein p63 0.1029 0.1695 0.1695
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0009 0.0023
Trichomonas vaginalis ras GTP exchange factor, putative 0.0033 0.0017 0.009
Schistosoma mansoni cpg binding protein 0.0217 0.0328 0.0797
Schistosoma mansoni tar DNA-binding protein 0.0457 0.0733 0.1783
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0004 0.0022
Trichomonas vaginalis glutaminase, putative 0.0282 0.0437 0.2297
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0017 0.0017
Echinococcus granulosus tumor protein p63 0.1029 0.1695 0.4124
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0341 0.0537 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0041 0.0112
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0046 0.075
Plasmodium vivax thioredoxin reductase, putative 0.0135 0.0189 0.0994
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0307 0.048 0.8913
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0009 0.005
Loa Loa (eye worm) hypothetical protein 0.0046 0.0039 0.0108
Onchocerca volvulus Protein patched homolog 0.003 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Entamoeba histolytica cysteine protease, putative 0.0261 0.0402 0.2113
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0033 0.0017 0.009
Echinococcus multilocularis Smad4 0.007 0.008 0.008
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0047 0.0245
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.0368 0.1012
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0361 0.0571 0.1568
Schistosoma mansoni Smad4 0.007 0.008 0.0194
Echinococcus granulosus dnaJ subfamily B 0.2462 0.411 1
Plasmodium falciparum serine repeat antigen 2 0.0261 0.0402 0.2113
Loa Loa (eye worm) hypothetical protein 0.0095 0.0123 0.0338
Plasmodium vivax importin-beta 2, putative 0.003 0.0014 0.0071
Echinococcus multilocularis para nitrobenzyl esterase 0.0069 0.0078 0.0078
Onchocerca volvulus 0.003 0.0013 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0027 0.0448
Entamoeba histolytica cysteine protease, putative 0.0261 0.0402 0.2113
Echinococcus multilocularis geminin 0.0721 0.1177 0.1177
Leishmania major importin beta-1 subunit, putative 0.0025 0.0004 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0027 0.0027
Brugia malayi glutathione reductase 0.0135 0.0189 0.052
Giardia lamblia Replication factor C, subunit 1 0.005 0.0047 0.0332
Brugia malayi Calcitonin receptor-like protein seb-1 0.0822 0.1346 0.3701
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0047 0.0245
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0031 0.0076
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0031 0.0015 0.0028
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0069 0.0078 0.019
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0005 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0031 0.0076
Entamoeba histolytica cysteine protease, putative 0.0261 0.0402 0.2113
Onchocerca volvulus 0.003 0.0013 0.0021
Trypanosoma cruzi trypanothione reductase, putative 0.0135 0.0189 0.052
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.0095 0.0123 0.0338
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi mothers against decapentaplegic homolog 3 0.0031 0.0015 0.0041
Brugia malayi MH2 domain containing protein 0.007 0.008 0.0219
Loa Loa (eye worm) RNA binding protein 0.0457 0.0733 0.2014
Giardia lamblia Cathepsin B precursor 0.0855 0.1403 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0031 0.0076
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.0216 0.0525
Schistosoma mansoni survival motor neuron protein 0.0051 0.0048 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0041 0.0213
Onchocerca volvulus Cathepsin L homolog 0.1152 0.1903 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0031 0.0076
Trypanosoma cruzi cysteine peptidase, putative 0.1152 0.1903 0.5229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0622 0.101 0.531
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0307 0.048 0.892
Brugia malayi Carboxylesterase family protein 0.0069 0.0078 0.0215
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.0722 0.0722
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0047 0.0245
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0026
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0033 0.0017 0.0047
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0017 0.0042
Mycobacterium ulcerans carboxylesterase, LipT 0.0069 0.0078 0.1556
Echinococcus multilocularis importin subunit beta 1 0.003 0.0014 0.0014
Echinococcus granulosus sterol regulatory element binding protein 0.0215 0.0324 0.0789
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0123 0.2572
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0128
Giardia lamblia Cathepsin L precursor 0.0261 0.0402 0.2865
Onchocerca volvulus 0.003 0.0013 0.0021
Brugia malayi DIX domain containing protein 0.0046 0.0039 0.0108
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0261 0.0402 0.2113
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0009 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0261 0.0402 0.2113
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0028 0.015
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0047 0.0245
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0037
Echinococcus granulosus regulator of G protein signaling 7 0.0046 0.0039 0.0096
Toxoplasma gondii hypothetical protein 0.0046 0.0039 0.0207
Giardia lamblia Cathepsin L precursor 0.0261 0.0402 0.2865
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.005 0.0047 0.0245
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2182 0.3638 1
Schistosoma mansoni chromosome transmission fidelity factor 0.005 0.0047 0.0113
Brugia malayi cathepsin L-like cysteine proteinase 0.0261 0.0402 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Chlamydia trachomatis DNA ligase 0.005 0.0047 0.1166
Brugia malayi glutaminase DH11.1 0.0282 0.0437 0.1201
Loa Loa (eye worm) hypothetical protein 0.0194 0.0289 0.0793
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0086
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0261 0.0402 0.1105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0082 0.1651
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0023 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0051 0.0048 0.0117
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0025 0.0005 0.0026
Brugia malayi protein C24B5.3 0.003 0.0013 0.0037
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.027 0.0417 0.7742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0622 0.101 0.531
Plasmodium falciparum thioredoxin reductase 0.0135 0.0189 0.0994
Schistosoma mansoni topbp1 0.005 0.0047 0.0113
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0046 0.0039 0.0096
Brugia malayi hypothetical protein 0.0046 0.0039 0.0108
Schistosoma mansoni smad1 5 8 and 0.007 0.008 0.0194
Brugia malayi follicle stimulating hormone receptor 0.0241 0.0368 0.1012
Plasmodium vivax glutathione reductase, putative 0.0135 0.0189 0.0994
Entamoeba histolytica hypothetical protein 0.0221 0.0334 0.1755
Echinococcus multilocularis ras GTP exchange factor 0.0033 0.0017 0.0017
Schistosoma mansoni Smad4 0.0031 0.0015 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0031 0.0076
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.093 0.1529 0.8025
Brugia malayi regulator of G-protein signaling egl-10 0.0046 0.0039 0.0108
Giardia lamblia Cathepsin L precursor 0.0261 0.0402 0.2865
Plasmodium vivax vivapain-2 0.1152 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi Patched related family protein 12 0.003 0.0013 0.0037
Schistosoma mansoni gliotactin 0.0069 0.0078 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0009 0.0009
Brugia malayi hypothetical protein 0.003 0.0013 0.0037
Echinococcus multilocularis cpg binding protein 0.0217 0.0328 0.0328
Trypanosoma cruzi cysteine proteinase, putative 0.0622 0.101 0.2777
Giardia lamblia Cathepsin B precursor 0.0261 0.0402 0.2865
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0327 0.0513 0.0513
Giardia lamblia Cysteine protease 0.0261 0.0402 0.2865
Plasmodium falciparum cysteine proteinase falcipain 1 0.0622 0.101 0.531
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0009 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0027 0.2443
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0009 0.0026
Brugia malayi RNA recognition motif domain containing protein 0.0457 0.0733 0.2014
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.005 0.0047 0.0841
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0009 0.005
Plasmodium vivax acyl-CoA synthetase, putative 0.0071 0.0082 0.0433
Echinococcus multilocularis smad 0.007 0.008 0.008
Brugia malayi cathepsin B-like cysteine proteinase 0.2182 0.3638 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0041 0.0215
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0031 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0112
Brugia malayi hypothetical protein 0.025 0.0383 0.1053
Schistosoma mansoni hypothetical protein 0.0207 0.0311 0.0757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1152 0.1903 1
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Trypanosoma brucei cysteine peptidase C (CPC) 0.0855 0.1403 0.7373
Trypanosoma cruzi cysteine peptidase, putative 0.1152 0.1903 0.5229
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.005 0.0047 0.0245
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.029 0.0451 1
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.005 0.0047 0.0758
Plasmodium vivax serine-repeat antigen (SERA) 0.0261 0.0402 0.2113
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0261 0.0402 0.2113
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0128
Loa Loa (eye worm) cysteine protease 0.1152 0.1903 0.5229
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1152 0.1903 0.5229
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.002 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0031 0.0086
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0033 0.0017 0.0042
Echinococcus granulosus mixed lineage leukemia protein mll 0.0051 0.0048 0.0117
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0261 0.0402 0.2113
Echinococcus granulosus Pleckstrin G protein interacting region 0.0046 0.0039 0.0096
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0009 0.0123
Entamoeba histolytica hypothetical protein 0.0221 0.0334 0.1755
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0855 0.1403 0.7373
Brugia malayi N-terminal motif family protein 0.0033 0.0017 0.0047
Loa Loa (eye worm) hypothetical protein 0.0468 0.0751 0.2064
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0023 0.012
Echinococcus granulosus nibrin 0.005 0.0047 0.0113
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0023 0.0023
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0261 0.0402 0.2113
Leishmania major cysteine peptidase A (CPA) 0.1152 0.1903 1
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0009 0.005
Plasmodium falciparum lipid/sterol:H+ symporter 0.003 0.0013 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0031 0.0076
Loa Loa (eye worm) hypothetical protein 0.0822 0.1346 0.3701
Brugia malayi hypothetical protein 0.0468 0.0751 0.2064
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0027 0.0141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0041 0.0112
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0023 0.0055
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0261 0.0402 0.1105
Schistosoma mansoni hypothetical protein 0.0562 0.0908 0.221
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.0722 0.1757
Toxoplasma gondii cathepsin B 0.0855 0.1403 0.7373
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0009 0.0059
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0041 0.0215
Echinococcus granulosus importin subunit beta 1 0.003 0.0014 0.0033
Giardia lamblia Cysteine protease 0.0261 0.0402 0.2865
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0123 0.0338
Toxoplasma gondii patched family protein 0.003 0.0013 0.007
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0261 0.0402 0.2865
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.0402 0.2113
Toxoplasma gondii hypothetical protein 0.0026 0.0006 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0041 0.0215
Entamoeba histolytica hypothetical protein 0.0221 0.0334 0.1755
Plasmodium falciparum importin beta, putative 0.003 0.0014 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0027 0.0074
Echinococcus granulosus cathepsin L cysteine proteinase 0.1152 0.1903 0.4629
Trypanosoma cruzi major cysteine proteinase, putative 0.0261 0.0402 0.1105
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0033 0.0018 0.0093
Onchocerca volvulus 0.0069 0.0078 0.0363
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0009 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.009 0.158
Mycobacterium ulcerans hypothetical protein 0.0095 0.0123 0.2572
Echinococcus multilocularis Niemann Pick C1 protein 0.0716 0.1168 0.1168
Entamoeba histolytica cysteine protease, putative 0.1152 0.1903 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0027 0.0074
Onchocerca volvulus 0.1152 0.1903 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0009 0.005
Toxoplasma gondii cathepsin CPC1 0.0261 0.0402 0.2113
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.009 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0261 0.0402 0.2113
Brugia malayi cathepsin F-like cysteine proteinase 0.0361 0.0571 0.1568
Echinococcus granulosus cathepsin b 0.2182 0.3638 0.8852
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0123 0.0647
Brugia malayi MH1 domain containing protein 0.0039 0.0027 0.0075
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0028 0.015
Echinococcus granulosus acetylcholinesterase 0.0407 0.0649 0.1578
Echinococcus multilocularis regulator of G protein signaling 7 0.0046 0.0039 0.0039
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1152 0.1903 1
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0033 0.0017 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Loa Loa (eye worm) hypothetical protein 0.0791 0.1294 0.3557
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0071 0.0082 0.8408
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0041 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0017 0.0046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1152 0.1903 0.1903
Echinococcus granulosus tar DNA binding protein 0.0457 0.0733 0.1783
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0046 0.0112
Brugia malayi RasGEF domain containing protein 0.0033 0.0017 0.0047
Entamoeba histolytica protein kinase, putative 0.0195 0.029 0.1525
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0005 0.0026
Brugia malayi Carboxylesterase family protein 0.0069 0.0078 0.0215
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0261 0.0402 0.0978
Echinococcus granulosus cathepsin l1 0.1152 0.1903 0.4629
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0031 0.0086
Brugia malayi Cathepsin L-like precursor 0.1152 0.1903 0.5229
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0009 0.005
Schistosoma mansoni tar DNA-binding protein 0.0457 0.0733 0.1783
Loa Loa (eye worm) fibroinase 0.1152 0.1903 0.5229
Loa Loa (eye worm) hypothetical protein 0.2182 0.3638 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0128
Loa Loa (eye worm) DIX domain-containing protein 0.0046 0.0039 0.0108
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Brugia malayi Carboxylesterase family protein 0.0407 0.0649 0.1783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1152 0.1903 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0075
Plasmodium falciparum glutathione reductase 0.0047 0.0041 0.0215
Brugia malayi CXXC zinc finger family protein 0.0205 0.0308 0.0847
Onchocerca volvulus 0.003 0.0013 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0112
Loa Loa (eye worm) hypothetical protein 0.0261 0.0402 0.1105
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0031 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0123 0.2572
Brugia malayi ecdysteroid receptor 0.0041 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0261 0.0402 0.2113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0822 0.1346 0.3701
Echinococcus granulosus regulator of G protein signaling 7 0.0046 0.0039 0.0096
Plasmodium falciparum cysteine proteinase falcipain 3 0.1152 0.1903 1
Onchocerca volvulus 0.1152 0.1903 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0009 0.005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0135 0.019 0.019
Echinococcus granulosus snurportin 1 0.0325 0.051 0.1241
Entamoeba histolytica hypothetical protein 0.0221 0.0334 0.1755
Echinococcus multilocularis dual specificity 0.0195 0.029 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0076 0.1365
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0051 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Brugia malayi RasGEF domain containing protein 0.0033 0.0017 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0031 0.0076
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0026
Schistosoma mansoni hypothetical protein 0.0207 0.0311 0.0757
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0031 0.0086
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0034 0.0181
Echinococcus granulosus cysteine protease 0.0622 0.101 0.2458
Schistosoma mansoni glutaminase 0.0282 0.0437 0.1063
Mycobacterium ulcerans glutaminase 0.0282 0.0437 0.9677
Toxoplasma gondii hypothetical protein 0.003 0.0013 0.007
Echinococcus multilocularis TGF beta signal transducer SmadC 0.007 0.008 0.008
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0791 0.1294 0.3557
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0004 0.002
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0041 0.0711
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0195 0.029 0.0798
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0009 0.005
Loa Loa (eye worm) hypothetical protein 0.0562 0.0908 0.2497
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0009 0.005
Echinococcus granulosus geminin 0.0721 0.1177 0.2863
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0261 0.0402 0.2113
Schistosoma mansoni hypothetical protein 0.0221 0.0334 0.0812
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0071 0.0082 0.1487
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.009 0.022
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0009 0.0059
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0123
Echinococcus granulosus son of sevenless 1 0.0033 0.0017 0.0042
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0009 0.005
Loa Loa (eye worm) hypothetical protein 0.025 0.0383 0.1053
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0855 0.1403 0.3413
Plasmodium falciparum serine repeat antigen 3 0.0261 0.0402 0.2113
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0078 0.1409
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1152 0.1903 1
Giardia lamblia Cathepsin B precursor 0.0261 0.0402 0.2865
Brugia malayi Cathepsin L-like precursor 0.0361 0.0571 0.1568
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0041 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0047
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0041 0.0215
Brugia malayi Patched family protein 0.003 0.0013 0.0037
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0041 0.0041
Echinococcus multilocularis mothers against decapentaplegic 6 0.0031 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0071 0.0082 0.0226
Trypanosoma cruzi cruzipain precursor, putative 0.1152 0.1903 0.5229
Loa Loa (eye worm) hypothetical protein 0.0069 0.0078 0.0215
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.029 0.0706
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0014 0.0071
Entamoeba histolytica cysteine protease, putative 0.0622 0.101 0.531
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0017 0.0017
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0041 0.0112
Giardia lamblia Cathepsin L precursor 0.0261 0.0402 0.2865
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0031 0.0076
Entamoeba histolytica protein kinase domain containing protein 0.0195 0.029 0.1525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1152 0.1903 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0023 0.012
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0031 0.0076
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0123 0.2198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0078 0.019
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0041 0.0215
Schistosoma mansoni cathepsin F (C01 family) 0.1152 0.1903 0.4629
Brugia malayi Probable ClpP-like protease 0.0076 0.009 0.0248
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0023 0.0055
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0123 0.2198
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.1152 0.1903 0.5229
Brugia malayi N-terminal motif family protein 0.093 0.1529 0.4202
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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