Detailed information for compound 1309603

Basic information

Technical information
  • TDR Targets ID: 1309603
  • Name: (5Z)-3-(3,5-dimethylphenyl)-5-[(2-methoxyphen yl)methylidene]-2-(3-nitrophenyl)-1,1-dioxo-1 ,3-thiazolidin-4-one
  • MW: 478.517 | Formula: C25H22N2O6S
  • H donors: 0 H acceptors: 5 LogP: 4.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1/C=C\1/C(=O)N(C(S1(=O)=O)c1cccc(c1)[N+](=O)[O-])c1cc(C)cc(c1)C
  • InChi: 1S/C25H22N2O6S/c1-16-11-17(2)13-21(12-16)26-24(28)23(15-18-7-4-5-10-22(18)33-3)34(31,32)25(26)19-8-6-9-20(14-19)27(29)30/h4-15,25H,1-3H3/b23-15-
  • InChiKey: NOTYIPVHEGHBSO-HAHDFKILSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-3-(3,5-dimethylphenyl)-5-[(2-methoxyphenyl)methylene]-2-(3-nitrophenyl)-1,1-dioxo-1,3-thiazolidin-4-one
  • (5Z)-3-(3,5-dimethylphenyl)-1,1-diketo-5-(2-methoxybenzylidene)-2-(3-nitrophenyl)-1,3-thiazolidin-4-one
  • (5Z)-3-(3,5-dimethylphenyl)-5-(2-methoxybenzylidene)-2-(3-nitrophenyl)-1,3-thiazolidin-4-one 1,1-dioxide
  • MLS000583823
  • SMR000206809

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Brugia malayi beta-lactamase 0.0081 0.0076 0.2736
Echinococcus granulosus lamin 0.0081 0.0075 0.073
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0026 0.2175
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0076 0.0074
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0046 0.1313
Trypanosoma brucei protein kinase, putative 0.0055 0.0046 0.1313
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0021 0.02
Schistosoma mansoni hypothetical protein 0.0089 0.0086 0.0831
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0076 0.074
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0026 0.0085
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0076 0.2238
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0123 0.3357
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0002 0.0005
Brugia malayi CHE-14 protein 0.0093 0.009 0.3217
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0041 0.1174
Echinococcus multilocularis snurportin 1 0.0327 0.0368 0.1182
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0018 0.0487
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0037 0.0361
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0018 0.0174
Onchocerca volvulus Huntingtin homolog 0.0124 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0127 0.3459
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0707
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0116 0.4141
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.0279 0.7597
Loa Loa (eye worm) hypothetical protein 0.0173 0.0185 0.502
Giardia lamblia Kinase, PLK 0.0115 0.0116 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.008 0.2172
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0075 0.0723
Schistosoma mansoni coup transcription factor 0.0032 0.0018 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0018 0.0487
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.008 0.2859
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0046 0.0146
Loa Loa (eye worm) inositol-1 0.0039 0.0026 0.0719
Mycobacterium tuberculosis Conserved protein 0.0081 0.0076 0.0074
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0116 0.0372
Loa Loa (eye worm) hypothetical protein 0.0081 0.0075 0.2051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.001 0.0712
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0008 0.0352
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0003 0.0001
Onchocerca volvulus 0.0081 0.0076 0.5827
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0156 0.0501
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0156 0.151
Onchocerca volvulus 0.0081 0.0076 0.5827
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0022 0.0019
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0003 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0018 0.0174
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0013 0.036
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0003 0.0044
Leishmania major DNA polymerase eta, putative 0.002 0.0003 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0018 0.0642
Onchocerca volvulus 0.0081 0.0075 0.5744
Plasmodium falciparum importin beta, putative 0.0031 0.0016 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0045 0.0145
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0018 0.0174
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0002 0.0016
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0008 0.0852
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0123 0.3357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.001 0.035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2643 0.3111 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0046 0.1313
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0006 0.0118
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0003 0.0044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0003 0.0128
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0003 0.003
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0022 0.0006 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0075 0.27
Schistosoma mansoni hypothetical protein 0.0327 0.0368 0.3559
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0116 0.3412
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0026 0.0252
Brugia malayi steroid hormone receptor 0.0032 0.0018 0.0642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0156 0.151
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0018 0.0174
Schistosoma mansoni DNA ligase IV 0.0022 0.0006 0.0054
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0002 0.006
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0076 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.0279 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0008 0.0191
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0154 0.0496
Echinococcus multilocularis protein patched 0.0093 0.009 0.0289
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0047 0.0035 0.0341
Loa Loa (eye worm) hypothetical protein 0.0253 0.0279 0.7597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0018 0.0487
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0018 0.0174
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0002 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0025 0.001 0.0346
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0742
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2079
Mycobacterium ulcerans TetR family transcriptional regulator 0.8458 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0051 0.0492
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0008 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0022 0.0006 0.0116
Echinococcus multilocularis geminin 0.0889 0.1033 0.332
Brugia malayi Cytochrome P450 family protein 0.0019 0.0002 0.0079
Brugia malayi hypothetical protein 0.0026 0.001 0.0366
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.001 0.0243
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.0236 0.2285
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.034
Toxoplasma gondii FATC domain-containing protein 0.0025 0.001 0.1086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0156 0.0501
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Brugia malayi RNA, U transporter 1 0.0087 0.0083 0.2979
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0018 0.0642
Entamoeba histolytica hypothetical protein 0.0154 0.0162 0.6844
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0018 0.0174
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0046 0.1313
Leishmania major cytochrome p450-like protein 0.0019 0.0002 0.0016
Brugia malayi follicle stimulating hormone receptor 0.0228 0.025 0.8962
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0151
Brugia malayi cytochrome P450 0.0019 0.0002 0.0079
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0009 0.0677
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2079
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0051 0.0163
Brugia malayi Latrophilin receptor protein 2 0.008 0.0075 0.2673
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0071 0.1919
Loa Loa (eye worm) beta-lactamase 0.0081 0.0076 0.2079
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0018 0.0642
Leishmania major hypothetical protein, conserved 0.0026 0.001 0.0256
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0007 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0309 0.0346 0.1112
Schistosoma mansoni topbp1 0.0022 0.0006 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0071 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0031 0.0845
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0037 0.2608
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0148 0.439
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.0278 0.2689
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0076 0.6559
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0003 0.0062
Brugia malayi hypothetical protein 0.0022 0.0006 0.0198
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0016 0.0436
Loa Loa (eye worm) hypothetical protein 0.0093 0.009 0.2444
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.0336 1
Onchocerca volvulus 0.0051 0.0041 0.2889
Toxoplasma gondii ATPase, AAA family protein 0.0022 0.0006 0.0519
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0008 0.0191
Leishmania major DNA polymerase kappa, putative 0.002 0.0003 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.0309 0.0346 0.335
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0167 0.0165
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0046 0.0146
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.008 0.0773
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.009 0.2444
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0018 0.0058
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0029 0.1024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0018 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0018 0.0174
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0045 0.0438
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0037 0.0361
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0148 0.439
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.001 0.0256
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0151
Brugia malayi hypothetical protein 0.0154 0.0162 0.5803
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0018 0.0174
Mycobacterium ulcerans transcriptional regulator 0.8458 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.001 0.0256
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0026 0.2175
Mycobacterium ulcerans hypothetical protein 0.0081 0.0076 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0018 0.0174
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0051 0.0049
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.0368 1
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0047 0.4013
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.009 0.0289
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0076 0.074
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0051 0.0492
Schistosoma mansoni topbp1 0.0022 0.0006 0.0054
Echinococcus granulosus nibrin 0.0022 0.0006 0.0054
Schistosoma mansoni niemann-pick C1 (NPC1) 0.022 0.024 0.2324
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.001 0.0256
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0018 0.1018
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.0185 0.6609
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0018 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0018 0.0642
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0156 0.151
Plasmodium vivax importin-beta 2, putative 0.0031 0.0016 0.151
Echinococcus granulosus dna polymerase eta 0.002 0.0003 0.003
Echinococcus granulosus dna polymerase kappa 0.002 0.0003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0004 0.0035
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0004 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0071 0.0683
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0002 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0003 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0051 0.0492
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.003 0.0847
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0018 0.0642
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0018 0.0174
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0018 0.0174
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0018 0.0058
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0037 0.0361
Onchocerca volvulus 0.0048 0.0037 0.2608
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0018 0.0642
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0002 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0051 0.0049
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.0238
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0076 0.2736
Entamoeba histolytica hypothetical protein 0.0022 0.0006 0.0165
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0723
Loa Loa (eye worm) hypothetical protein 0.0048 0.0037 0.1014
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 0.3847
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0041 0.1457
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0003 0.0085
Schistosoma mansoni hypothetical protein 0.0889 0.1033 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0051 0.1471
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0022 0.0006 0.0165
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.0278 0.0893
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.066
Onchocerca volvulus Huntingtin homolog 0.0124 0.0127 1
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0022 0.0006 0.0003
Mycobacterium ulcerans lipase LipD 0.0081 0.0076 0.0074
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0013 0.0347
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0016 0.195
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0002 0.0016
Mycobacterium ulcerans AcrR family transcriptional regulator 0.8458 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.0162 0.1569
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0018 0.0174
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.0279 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0037 0.012
Schistosoma mansoni hypothetical protein 0.0089 0.0086 0.0831
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0046 0.3847
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0024 0.086
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0018 0.0642
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0076 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0018 0.0642
Schistosoma mansoni kinase 0.0058 0.0049 0.0476
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0116 0.112
Schistosoma mansoni hypothetical protein 0.0889 0.1033 1
Leishmania major mitochondrial DNA polymerase beta 0.03 0.0336 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0116 0.4863
Schistosoma mansoni ran 0.0023 0.0007 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0076 0.0246
Brugia malayi hypothetical protein 0.0124 0.0127 0.4554
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0002 0.0016
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0046 0.0441
Schistosoma mansoni inositol monophosphatase 0.0039 0.0026 0.0256
Brugia malayi RNA binding protein 0.0076 0.0071 0.2526
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.0206 0.1993
Brugia malayi intermediate filament protein 0.0081 0.0075 0.27
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.003 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.034
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.008 0.0257
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0002 0.0016
Onchocerca volvulus 0.0032 0.0018 0.1018
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.009 0.087
Echinococcus multilocularis expressed conserved protein 0.0203 0.0221 0.0709
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0076 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0018 0.0642
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0018 0.0174
Trichomonas vaginalis ran, putative 0.0023 0.0007 0.0438
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0076 0.0074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0046 0.1313
Schistosoma mansoni hypothetical protein 0.0089 0.0086 0.0831
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0075 0.2051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0148 0.439
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.0206 0.0662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0156 0.151
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 0.3847
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0071 0.0683
Brugia malayi Inositol-1 0.0039 0.0026 0.0947
Echinococcus granulosus intermediate filament protein 0.0081 0.0075 0.073
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0022 0.0006 0.0198
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0026 0.1057
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0018 0.0174
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0002 0.0016
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0051 0.004 0.0128
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.001 0.4375
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0018 0.0058
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0008 0.0852
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 0.3847
Leishmania major importin beta-1 subunit, putative 0.0025 0.0009 0.0231
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0022 0.0006 0.0116
Echinococcus granulosus importin subunit beta 1 0.0031 0.0016 0.0157
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0723
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0046 0.0441
Leishmania major hypothetical protein, conserved 0.0081 0.0076 0.2238
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0018 0.0058
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.001 0.0243
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0723
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.1042
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0022 0.0006 0.0116
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0037 0.012
Loa Loa (eye worm) hypothetical protein 0.0216 0.0236 0.6421
Schistosoma mansoni hypothetical protein 0.0154 0.0162 0.1569
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0016 0.0052
Schistosoma mansoni lamin 0.0081 0.0075 0.073
Loa Loa (eye worm) hypothetical protein 0.0124 0.0127 0.3459
Echinococcus multilocularis 0.0019 0.0002 0.0007
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.0236 0.8452
Loa Loa (eye worm) hypothetical protein 0.0114 0.0115 0.3117
Onchocerca volvulus 0.0084 0.008 0.611
Brugia malayi Cytochrome P450 family protein 0.0059 0.005 0.18
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0076 0.074
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0026 0.3315
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0006 0.0116
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0046 0.1313
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0026 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0026 0.2175
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0016 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0018 0.0642
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0007 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0018 0.0058
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.0162 0.1569
Loa Loa (eye worm) MBCTL1 0.0055 0.0045 0.1229
Loa Loa (eye worm) cytochrome P450 0.0019 0.0002 0.006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0022 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0018 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0018 0.0642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0018 0.0174
Brugia malayi nuclear hormone receptor 0.0032 0.0018 0.0642
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0116 0.3412
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0009 0.0677
Brugia malayi beta-lactamase family protein 0.0081 0.0076 0.2736
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0013 0.036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0009 0.0231
Trypanosoma brucei polo-like protein kinase 0.0115 0.0116 0.3412
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0075 0.024
Brugia malayi hypothetical protein 0.0251 0.0278 0.9946
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0008 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.003 0.0847
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0085
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0076 0.0074
Onchocerca volvulus 0.0081 0.0075 0.5744
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0006 0.0116
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0076 0.0074
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0076 0.0074
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.025 0.6809
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.001 0.4375
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0002 0.0016
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0001
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0013 0.036
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.008 0.0773
Echinococcus granulosus metabotropic glutamate receptor 5 0.0051 0.004 0.0386
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0002 0.0016
Mycobacterium ulcerans beta-lactamase 0.0081 0.0076 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0075 0.2031
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0046 0.1313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0018 0.0058
Echinococcus granulosus tar DNA binding protein 0.0076 0.0071 0.0683
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.001 0.1145
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0742
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0002 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0336 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.1229
Entamoeba histolytica Ran family GTPase 0.0023 0.0007 0.0213
Loa Loa (eye worm) RNA binding protein 0.0076 0.0071 0.1919
Schistosoma mansoni intermediate filament proteins 0.0081 0.0075 0.073
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0003 0.0128
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0002 0.0016
Echinococcus granulosus Protein patched homolog 1 0.0093 0.009 0.087
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0071 0.0683
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0018 0.0642
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0026 0.0256
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0076 0.0074
Brugia malayi beta-lactamase family protein 0.0081 0.0076 0.2736
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0045 0.1618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0018 0.0487
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0742
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0003 0.001
Echinococcus granulosus expressed conserved protein 0.0203 0.0221 0.2135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0008 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.052 0.0597 0.0594
Echinococcus multilocularis musashi 0.0081 0.0075 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0018 0.1018
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0013 0.0347
Giardia lamblia DINP protein human, muc B family 0.002 0.0003 0.0128
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0009 0.0677
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0151
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0002 0.006
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0742
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0051 0.0049
Brugia malayi ecdysteroid receptor 0.0032 0.0018 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0018 0.0642
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0002 0.0074
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0037 0.0361
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0076 0.6559
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0008 0.1192
Echinococcus granulosus lamin dm0 0.0081 0.0075 0.073
Loa Loa (eye worm) hypothetical protein 0.0051 0.004 0.1084
Entamoeba histolytica hypothetical protein 0.0154 0.0162 0.6844
Schistosoma mansoni ran 0.0023 0.0007 0.0064
Mycobacterium ulcerans hypothetical protein 0.0158 0.0167 0.0165
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.066
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0003 0.0044
Mycobacterium leprae Probable lipase LipE 0.0081 0.0076 0.0074
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0007 0.0149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0442
Schistosoma mansoni hypothetical protein 0.0051 0.0041 0.0394
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0071 0.1919
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0018 0.0174
Brugia malayi Muscleblind-like protein 0.0147 0.0154 0.5525
Toxoplasma gondii hypothetical protein 0.0048 0.0037 0.4768
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0008 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0076 0.6559
Brugia malayi MH2 domain containing protein 0.0121 0.0123 0.4419
Giardia lamblia Replication factor C, subunit 1 0.0022 0.0006 0.034
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0076 0.0074
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0046 0.5865
Loa Loa (eye worm) hypothetical protein 0.0251 0.0278 0.7555
Brugia malayi mbt repeat family protein 0.0048 0.0037 0.1334
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0045 0.0438
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0076 1
Entamoeba histolytica hypothetical protein 0.0024 0.0008 0.0272
Schistosoma mansoni cytochrome P450 0.0019 0.0002 0.0021
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0008 0.0006
Echinococcus granulosus muscleblind protein 0.0147 0.0154 0.1494
Schistosoma mansoni hypothetical protein 0.0089 0.0086 0.0831
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0018 0.0174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0075 0.024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.0162 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0156 0.151
Echinococcus granulosus replication factor c subunit 1 0.0022 0.0006 0.0054
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0026 0.0084
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0075 0.2051
Echinococcus multilocularis protein dispatched 1 0.0106 0.0105 0.0339
Echinococcus multilocularis lamin 0.0081 0.0075 0.0242
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.001 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0003 0.0044
Mycobacterium tuberculosis Conserved protein 0.0081 0.0076 0.0074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.0156 0.5583
Leishmania major cytochrome p450-like protein 0.0019 0.0002 0.0016
Schistosoma mansoni chromosome transmission fidelity factor 0.0022 0.0006 0.0054
Brugia malayi DKFZp564C0469 protein 0.0022 0.0006 0.0198
Loa Loa (eye worm) glutamate receptor 0.0041 0.0029 0.0778
Echinococcus multilocularis muscleblind protein 0.0147 0.0154 0.0496
Echinococcus multilocularis GPCR, family 2 0.008 0.0075 0.024
Echinococcus granulosus GPCR family 2 0.008 0.0075 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0018 0.0487
Echinococcus granulosus geminin 0.0889 0.1033 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0487
Schistosoma mansoni DNA polymerase eta 0.002 0.0003 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0003 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0047 0.4013
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0116 0.3412
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0003 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.001 0.0661
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.003 0.0847
Onchocerca volvulus 0.0081 0.0076 0.5827
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0022 0.0006 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0076 0.6559
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0151
Loa Loa (eye worm) hypothetical protein 0.0147 0.0154 0.4197
Echinococcus granulosus snurportin 1 0.0327 0.0368 0.3559
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0018 0.0058
Entamoeba histolytica hypothetical protein 0.0025 0.0009 0.0329
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0007 0.0668
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0018 0.0642
Brugia malayi TAR-binding protein 0.0076 0.0071 0.2526
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0116 0.9051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0007 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0018 0.0487
Leishmania major cytochrome p450-like protein 0.0028 0.0013 0.0347
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.0181
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.0438
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0116 0.3145
Echinococcus granulosus serine protein kinase ATM 0.0025 0.001 0.0095
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0003 0.003
Brugia malayi Pax transcription activation domain interacting protein 0.0022 0.0006 0.0198
Leishmania major GTP-binding protein, putative 0.0023 0.0007 0.0149
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0003 0.0112
Brugia malayi topoisomerase 0.0022 0.0006 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0003 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0018 0.0642
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0051 0.6574
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0021 0.02
Brugia malayi Cytochrome P450 family protein 0.0028 0.0013 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0037 0.0361
Entamoeba histolytica hypothetical protein 0.0154 0.0162 0.6844
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0037 0.1014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.0236 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.005 0.1368
Schistosoma mansoni inositol monophosphatase 0.0039 0.0026 0.0256
Brugia malayi mbt repeat family protein 0.0048 0.0037 0.1334
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.0236 0.0759
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.8458 1 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0071 0.0227
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.0156 0.4241
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0022 0.0006 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0018 0.0487
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0022 0.0006 0.0518
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0031 0.1113
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.009 0.7737
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0075 0.2673
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0021 0.0067
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0008 0.0006
Schistosoma mansoni survival motor neuron protein 0.0051 0.0041 0.0394
Schistosoma mansoni hypothetical protein 0.0173 0.0185 0.1787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0018 0.0058
Echinococcus multilocularis dna polymerase eta 0.002 0.0003 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0116 0.112
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.034
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0026 1
Toxoplasma gondii ABC1 family protein 0.0081 0.0076 1
Trichomonas vaginalis esterase, putative 0.0081 0.0076 0.6559
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0723
Brugia malayi Importin beta-1 subunit 0.0031 0.0016 0.0582
Schistosoma mansoni lamin 0.0081 0.0075 0.073
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0044
Entamoeba histolytica hypothetical protein 0.0154 0.0162 0.6844
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0051 0.0049
Mycobacterium tuberculosis Conserved protein 0.0081 0.0076 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0071 0.0683
Trypanosoma brucei unspecified product 0.002 0.0003 0.0044
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0013 0.0011
Schistosoma mansoni patched 1 0.0093 0.009 0.087
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2079
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0046 0.1313
Loa Loa (eye worm) hypothetical protein 0.0079 0.0074 0.2004
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0045 0.0438
Trichomonas vaginalis replication factor C large subunit, putative 0.0022 0.0006 0.034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2079
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 0.3847
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0008 0.2328
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0022 0.0006 0.034
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0075 0.0723
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0076 0.2238
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0003 0.0001
Schistosoma mansoni importin beta-1 0.0031 0.0016 0.0157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0018 0.0174
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0018 0.1018
Echinococcus multilocularis lamin dm0 0.0081 0.0075 0.0242
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0076 0.2238
Brugia malayi Cytochrome P450 family protein 0.0028 0.0013 0.0474
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0336 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0007 0.0149
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0018 0.0174
Brugia malayi nuclear receptor NHR-88 0.0032 0.0018 0.0642
Echinococcus multilocularis dna polymerase kappa 0.002 0.0003 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0076 0.2079
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0013 0.0347
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0046 0.1238
Brugia malayi hypothetical protein 0.0022 0.0006 0.0198
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0022 0.0006 0.034
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0007 0.0149
Brugia malayi MAP kinase sur-1 0.0055 0.0046 0.163
Echinococcus multilocularis replication factor c subunit 1 0.0022 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0147 0.0154 0.4197
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2079
Echinococcus multilocularis nibrin 0.0022 0.0006 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0018 0.0174
Schistosoma mansoni hypothetical protein 0.0294 0.0329 0.318
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0076 0.6559
Loa Loa (eye worm) hypothetical protein 0.008 0.0075 0.2031
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.001 0.0095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0018 0.0487
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0071 0.2526
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0045 0.0145
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0046 0.0441
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0116 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.3371 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.