Detailed information for compound 1316767

Basic information

Technical information
  • TDR Targets ID: 1316767
  • Name: 3-(dimethylsulfamoyl)-N-(4-pyrrolidin-1-ylsul fonylphenyl)benzamide
  • MW: 437.533 | Formula: C19H23N3O5S2
  • H donors: 1 H acceptors: 5 LogP: 1.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)S(=O)(=O)N(C)C)Nc1ccc(cc1)S(=O)(=O)N1CCCC1
  • InChi: 1S/C19H23N3O5S2/c1-21(2)28(24,25)18-7-5-6-15(14-18)19(23)20-16-8-10-17(11-9-16)29(26,27)22-12-3-4-13-22/h5-11,14H,3-4,12-13H2,1-2H3,(H,20,23)
  • InChiKey: UHUAYZYOHDEIKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(dimethylsulfamoyl)-N-(4-1-pyrrolidinylsulfonylphenyl)benzamide
  • SMR000371673
  • ZINC03209771
  • Oprea1_028862
  • T0505-1411
  • MLS000774388

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin dm0 0.0022 0.0124 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1028 0.5317
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0303
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0022 0.012 0.064
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0428 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0428 0.0513
Leishmania major cathepsin L-like protease 0.0196 0.1923 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.2316 0.2774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0124 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0167
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.002 0.0107 0.0541
Echinococcus multilocularis acylamino acid releasing enzyme 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0106 0.0989 0.1184
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Echinococcus granulosus tar DNA binding protein 0.0062 0.0538 0.0644
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0218 0.2036
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0171 0.0834
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1353 1
Mycobacterium ulcerans beta-lactamase 0.011 0.1028 0.7529
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0428 0.1455
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0016 0.0066 0.0229
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0653 0.4687
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0164 0.0208
Plasmodium vivax vivapain-1 0.0027 0.0171 0.1569
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0078 0.1599
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Echinococcus granulosus geminin 0.0205 0.2008 0.2405
Schistosoma mansoni patched 1 0.0042 0.0329 0.0394
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2316 0.2316
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0078 0.032
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.003 0.0211 0.0274
Mycobacterium ulcerans thioesterase 0.0017 0.0072 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Trypanosoma cruzi cruzipain precursor, putative 0.0196 0.1923 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0329 0.1108
Brugia malayi beta-lactamase family protein 0.011 0.1028 0.1231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0378 0.0453
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0218 0.0261
Plasmodium vivax vivapain-3 0.0027 0.0171 0.1569
Schistosoma mansoni CD36-like class B scavenger receptor 0.0229 0.2255 0.2701
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0011 0.0011 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0139 0.0786
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Loa Loa (eye worm) hypothetical protein 0.0052 0.0428 0.0513
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0819 0.835 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0786
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0078 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.081 0.8254 0.8254
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1028 0.1231
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0022 0.012 0.0146
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0401 0.048
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Mycobacterium tuberculosis Probable peptidase 0.0042 0.0331 0.0443
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0042 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.092 0.1101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0171 0.0834
Onchocerca volvulus 0.0052 0.0428 0.19
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1028 0.1423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1304 0.1304
Toxoplasma gondii cathepsin CPL 0.0052 0.0428 0.4106
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0271 0.0324
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0329 0.0329
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0022 0.012 0.064
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1028 0.3545
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0011 0.0013 0.0016
Echinococcus multilocularis tumor protein p63 0.0334 0.3344 0.3344
Echinococcus granulosus intermediate filament protein 0.0022 0.0124 0.0149
Schistosoma mansoni loxhd1 0.0019 0.0096 0.0115
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0819 0.835 1
Echinococcus multilocularis muscleblind protein 0.0151 0.145 0.145
Echinococcus granulosus cathepsin L 0.0027 0.0171 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Schistosoma mansoni intermediate filament proteins 0.0022 0.0124 0.0149
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0164 0.0197
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.0311
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0428 0.0513
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Plasmodium vivax unspecified product 0.0017 0.0072 0.0603
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Trypanosoma cruzi oligopeptidase b 0.0042 0.0331 0.1672
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0218 0.1083
Echinococcus multilocularis lamin dm0 0.0022 0.0124 0.0124
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0105 0.0983 0.1178
Schistosoma mansoni hypothetical protein 0.0036 0.0271 0.0324
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0022 0.012 0.0146
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0106 0.0989 0.1184
Schistosoma mansoni hypothetical protein 0.0048 0.039 0.0467
Onchocerca volvulus 0.0022 0.0124 0.0552
Leishmania major cathepsin L-like protease 0.0196 0.1923 1
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.1923 1
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1028 0.3545
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.002 0.0107 0.0128
Brugia malayi prolyl oligopeptidase family protein 0.0106 0.0989 0.1184
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Mycobacterium leprae Probable lipase LipE 0.011 0.1028 0.7529
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0408 0.9506
Mycobacterium ulcerans hypothetical protein 0.011 0.1028 0.7529
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.142 0.17
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0904 0.0904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0171 0.0834
Echinococcus multilocularis lysosome membrane protein 2 0.0229 0.2255 0.2255
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.142 0.17
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1028 0.1231
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0378 0.0453
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0653 0.0653
Trypanosoma brucei prolyl oligopeptidase, putative 0.0042 0.0331 0.1672
Brugia malayi STAT protein, DNA binding domain containing protein 0.0157 0.1511 0.181
Leishmania major hypothetical protein, conserved 0.005 0.0408 0.2075
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.2878 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.145 0.1736
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.6957 0.8332
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0394
Loa Loa (eye worm) STAT protein 0.0157 0.1511 0.181
Loa Loa (eye worm) hypothetical protein 0.0101 0.0938 0.1123
Echinococcus multilocularis muscleblind protein 1 0.0151 0.145 0.145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1028 0.1423
Mycobacterium tuberculosis Polyketide synthase Pks2 0.002 0.01 0.0119
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1028 0.1423
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0378 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Onchocerca volvulus 0.0048 0.039 0.173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1028 0.7529
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0011 0.0011 0.0049
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Echinococcus granulosus prolyl endopeptidase 0.0106 0.0989 0.1184
Schistosoma mansoni cd36 antigen 0.0086 0.0787 0.0943
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0096 0.2036
Brugia malayi hypothetical protein 0.0086 0.0787 0.0943
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0408 0.9506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0538 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi beta-lactamase 0.011 0.1028 0.1231
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0408 0.2075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.2255 0.2701
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1028 0.1028
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0022 0.012 0.0146
Loa Loa (eye worm) hypothetical protein 0.0098 0.0904 0.1083
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0042 0.0331 0.1672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0171 0.0556
Trypanosoma brucei prolyl endopeptidase 0.0106 0.0989 0.5113
Loa Loa (eye worm) fibroinase 0.0052 0.0428 0.0513
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0357 0.3401
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1028 0.1423
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Onchocerca volvulus 0.0052 0.0428 0.19
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0428 0.0513
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Echinococcus multilocularis cpg binding protein 0.006 0.0517 0.0517
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0786
Onchocerca volvulus 0.0052 0.0428 0.19
Loa Loa (eye worm) hypothetical protein 0.0086 0.0787 0.0943
Toxoplasma gondii ABC1 family protein 0.011 0.1028 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0096 0.0115
Loa Loa (eye worm) hypothetical protein 0.0105 0.0983 0.1178
Echinococcus granulosus muscleblind protein 0.0151 0.145 0.1736
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0078 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.1304 0.1562
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.142 0.17
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.7122 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Schistosoma mansoni survival motor neuron protein 0.0048 0.039 0.0467
Brugia malayi beta-lactamase family protein 0.011 0.1028 0.1231
Onchocerca volvulus Fatty acid synthase homolog 0.0037 0.0276 0.1222
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0428 0.2183
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0072 0.0087
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.2878 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0428 0.19
Mycobacterium tuberculosis Conserved protein 0.011 0.1028 0.1423
Brugia malayi hypothetical protein 0.0019 0.0096 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Brugia malayi CD36 family protein 0.0229 0.2255 0.2701
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0042 0.0331 0.2241
Trypanosoma cruzi major cysteine proteinase, putative 0.0154 0.1489 0.7731
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0167
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Brugia malayi hypothetical protein 0.0086 0.0787 0.0943
Brugia malayi Cathepsin L-like precursor 0.0035 0.0253 0.0303
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0819 0.835 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0115
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0022 0.012 0.064
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2316 0.2774
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0011 0.0011 0.0013
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0011 0.0011 0.0013
Echinococcus multilocularis protein dispatched 1 0.0048 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0096 0.0096
Echinococcus granulosus dnaJ subfamily B 0.081 0.8254 0.9886
Schistosoma mansoni cpg binding protein 0.0057 0.0483 0.0579
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0139 0.0447
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0653 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Schistosoma mansoni cpg binding protein 0.006 0.0517 0.0619
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0096 0.0115
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0171 0.0556
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1028 0.5317
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0329 0.0394
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0357 0.1206
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0428 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0271 0.0324
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0295 0.0354
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0078 0.0656
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0428 0.0513
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.002 0.0107 0.0128
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0126 0.0151
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0428 1
Schistosoma mansoni hypothetical protein 0.0022 0.0126 0.0151
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0096 0.0115
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0107 0.0541
Schistosoma mansoni polycystin 1-related 0.0019 0.0096 0.0115
Schistosoma mansoni rab6-interacting 0.0019 0.0096 0.0115
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0017 0.0072 0.0275
Loa Loa (eye worm) hypothetical protein 0.0022 0.012 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus granulosus cathepsin l1 0.0035 0.0253 0.0303
Brugia malayi hypothetical protein 0.0036 0.0271 0.0324
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0309 0.2071
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0139 0.0786
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0483 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Mycobacterium ulcerans hypothetical protein 0.0024 0.0139 0.0786
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0229 0.2255 0.2701
Loa Loa (eye worm) hypothetical protein 0.0229 0.2255 0.2701
Schistosoma mansoni rab6-interacting 0.0019 0.0096 0.0115
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1353 0.1882
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1336 0.1336
Mycobacterium tuberculosis Conserved protein 0.011 0.1028 0.1423
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1028 0.1423
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0218 0.2036
Mycobacterium leprae Probable polyketide synthase Pks1 0.0022 0.012 0.064
Onchocerca volvulus 0.0052 0.0428 0.19
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0095 0.0874 0.1207
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0428 0.0428
Echinococcus multilocularis protein patched 0.0042 0.0329 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus granulosus tumor protein p63 0.0334 0.3344 0.4005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0218
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0011 0.0011 0.0013
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.1747 0.908
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.0064
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0218 0.496
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.0167
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0011 0.0011 0.0013
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0042 0.0331 0.1672
Schistosoma mansoni CD36-like class B scavenger receptor 0.0229 0.2255 0.2701
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0819 0.835 0.835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0428 0.19
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0042 0.0051
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Schistosoma mansoni inositol monophosphatase 0.0045 0.0357 0.0427
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0042 0.0331 0.2241
Onchocerca volvulus 0.011 0.1028 0.4556
Onchocerca volvulus 0.0019 0.0096 0.0426
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.109 0.1305
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2878 1
Schistosoma mansoni lamin 0.0022 0.0124 0.0149
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0171 0.0204
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1028 0.1423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.0167
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1028 0.3545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0115
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0171 0.3821
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2878 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.067
Toxoplasma gondii prolyl endopeptidase 0.0106 0.0989 0.9617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi Muscleblind-like protein 0.0151 0.145 0.1736
Loa Loa (eye worm) prolyl oligopeptidase 0.0011 0.0011 0.0013
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0072 0.0321
Mycobacterium ulcerans lipase LipD 0.011 0.1028 0.7529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Trypanosoma brucei oligopeptidase b 0.0042 0.0331 0.1672
Echinococcus granulosus Dipeptidyl peptidase 9 0.0011 0.0011 0.0013
Schistosoma mansoni cpg binding protein 0.006 0.0517 0.0619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0019 0.0022
Plasmodium vivax unspecified product 0.0027 0.0171 0.1569
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Onchocerca volvulus 0.0035 0.0253 0.112
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1028 0.7529
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0428 0.0513
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.1923 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.039 0.0467
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0107 0.0128
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1028 0.1231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1008 0.9811
Onchocerca volvulus 0.0052 0.0428 0.19
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0171 0.0204
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0096 0.0836
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0171 0.0834
Schistosoma mansoni lamin 0.0022 0.0124 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0329 0.0394
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0428 1
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0408 0.2075
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Onchocerca volvulus 0.0042 0.0334 0.148
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Echinococcus granulosus microtubule associated protein 2 0.0684 0.6957 0.8332
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0087
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0218 0.1083
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.002 0.0107 0.0541
Onchocerca volvulus 0.0019 0.0096 0.0426
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0408 0.2075
Toxoplasma gondii type I fatty acid synthase, putative 0.0015 0.0046 0.0346
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0357 0.1206
Loa Loa (eye worm) prolyl oligopeptidase 0.0011 0.0011 0.0013
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Loa Loa (eye worm) hypothetical protein 0.0049 0.0401 0.048
Echinococcus multilocularis expressed conserved protein 0.0092 0.0843 0.0843
Echinococcus multilocularis transcription factor eb 0.0106 0.0989 0.0989
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi RNA binding protein 0.0062 0.0538 0.0644
Echinococcus granulosus cysteine protease 0.0027 0.0171 0.0204
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0016 0.0066 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1028 0.5317
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0078 0.0094
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0126 0.0126
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0042 0.0042
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0538 0.0644
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1028 0.3545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0017 0.0069 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0011 0.0011 0.0011
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0072 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0408 0.3903
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0428 0.0428
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0378 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0218 0.0261
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0078 0.0094
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0357 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Brugia malayi Inositol-1 0.0045 0.0357 0.0427
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0096 0.0115
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0904 0.3114
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0218 0.1083
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0428 0.0428
Mycobacterium leprae conserved hypothetical protein 0.011 0.1028 0.7529
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0653 0.0896
Onchocerca volvulus 0.0026 0.0164 0.0729
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0106 0.0989 0.1184
Trypanosoma cruzi prolyl endopeptidase 0.0106 0.0989 0.5113
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0218 0.0218
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0229 0.2255 0.2701
Brugia malayi hypothetical protein 0.0234 0.2316 0.2774
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0106 0.0989 0.1184
Mycobacterium tuberculosis Probable thioesterase TesA 0.0017 0.0072 0.0078
Plasmodium vivax vivapain-2 0.0052 0.0428 0.4106
Echinococcus granulosus RUN 0.0019 0.0096 0.0115
Echinococcus multilocularis prolyl endopeptidase 0.0106 0.0989 0.0989
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0218 0.0284
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Mycobacterium tuberculosis Conserved protein 0.011 0.1028 0.1423
Mycobacterium ulcerans polyketide synthase Pks13 0.003 0.0211 0.133
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0357 0.1206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1304 0.1562
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0653 0.0782
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1304 0.1304
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0261
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0253 0.0842
Brugia malayi cathepsin L-like precursor 0.0035 0.0253 0.0303
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0042 0.0331 0.1672
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0253 0.0842
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0019 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0378 0.0453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0171 0.0556
Schistosoma mansoni hypothetical protein 0.0205 0.2008 0.2405
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0115
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0408 0.3903
Loa Loa (eye worm) hypothetical protein 0.0148 0.142 0.17
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.0167
Loa Loa (eye worm) cysteine protease 0.0052 0.0428 0.0513
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0253 0.0842
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1141 0.1367
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0078 0.0087
Onchocerca volvulus 0.011 0.1028 0.4556
Entamoeba histolytica cysteine protease, putative 0.0052 0.0428 0.1455
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1028 0.1231
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0428 0.2183
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0139 0.0786
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0017
Brugia malayi Cathepsin L-like precursor 0.0035 0.0253 0.0303
Onchocerca volvulus 0.011 0.1028 0.4556
Echinococcus granulosus lysosome membrane protein 2 0.0229 0.2255 0.2701
Schistosoma mansoni hypothetical protein 0.0205 0.2008 0.2405
Loa Loa (eye worm) hypothetical protein 0.0151 0.145 0.1736
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0087
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0171 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0357 0.2437
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.016 0.0521
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0253 0.0303
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0653 0.4687
Echinococcus multilocularis cysteine protease 0.0052 0.0428 0.0428
Echinococcus granulosus transcription factor eb 0.0106 0.0989 0.1184
Echinococcus multilocularis GPCR, family 2 0.0047 0.0378 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0171 0.0834
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Schistosoma mansoni lipoxygenase 0.0081 0.0731 0.0875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0218 0.0261
Loa Loa (eye worm) hypothetical protein 0.0051 0.0426 0.051
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0329 0.0394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Echinococcus granulosus lamin 0.0022 0.0124 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0164 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Leishmania major oligopeptidase b 0.0042 0.0331 0.1672
Schistosoma mansoni hypothetical protein 0.0101 0.0938 0.1123
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Loa Loa (eye worm) hypothetical protein 0.0086 0.0787 0.0943
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0538 0.0644
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0428 0.0428
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0428 0.1455
Loa Loa (eye worm) inositol-1 0.0045 0.0357 0.0427
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0042 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1304 0.1562
Echinococcus multilocularis cysteine protease 0.0052 0.0428 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus multilocularis cathepsin L 0.0027 0.0171 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1028 0.3545
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0218 0.1083
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0076 0.0091
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0171 0.0204
Echinococcus granulosus cathepsin l1 0.0052 0.0428 0.0513
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0139 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0139 0.0173
Loa Loa (eye worm) fatty acid synthase 0.002 0.0104 0.0125
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0904 0.1083
Onchocerca volvulus 0.0022 0.0124 0.0552
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0218
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Echinococcus multilocularis musashi 0.0022 0.0124 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0042 0.0331 0.1672
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0309 0.0412
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0072 0.0321
Echinococcus granulosus GPCR family 2 0.0047 0.0378 0.0453
Echinococcus granulosus expressed conserved protein 0.0092 0.0843 0.1009
Loa Loa (eye worm) hypothetical protein 0.0086 0.0787 0.0943
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0253 0.0303
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0011 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0.0007 0.0008
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0904 0.1083
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.1304 0.1562
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Toxoplasma gondii type I fatty acid synthase, putative 0.0023 0.013 0.1168
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.002 0.0107 0.0128
Mycobacterium ulcerans thioesterase TesA 0.0017 0.0072 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) ctsf protein 0.0052 0.0428 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0428 0.1455
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0139 0.0447
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) beta-lactamase 0.011 0.1028 0.1231
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.109 0.109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0022 0.012 0.064
Echinococcus granulosus cpg binding protein 0.006 0.0517 0.0619
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0087
Brugia malayi hypothetical protein 0.0019 0.0096 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Brugia malayi hypothetical protein 0.0032 0.0227 0.0271
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.002 0.0107 0.0541
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Plasmodium vivax hypothetical protein, conserved 0.011 0.1028 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0653 0.3358
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0303
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Schistosoma mansoni cathepsin s 0.0017 0.0072 0.0087
Onchocerca volvulus Prolyl endopeptidase homolog 0.0106 0.0989 0.4384
Brugia malayi CXXC zinc finger family protein 0.0057 0.0483 0.0579
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0124 0.0149
Brugia malayi hypothetical protein 0.005 0.0408 0.0488
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1353 1
Mycobacterium ulcerans polyketide synthase 0.002 0.0107 0.0541
Echinococcus granulosus acylamino acid releasing enzyme 0.0011 0.0011 0.0013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0357 0.1206
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1028 0.1231
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0428 1
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0653 0.4687
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0139 0.0786
Schistosoma mansoni inositol monophosphatase 0.0045 0.0357 0.0427
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0072 0.0087
Echinococcus multilocularis lamin 0.0022 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Onchocerca volvulus 0.0052 0.0428 0.19
Brugia malayi TAR-binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0819 0.835 1
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0229 0.2255 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Plasmodium vivax vivapain-2 0.0052 0.0428 0.4106
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Loa Loa (eye worm) hypothetical protein 0.005 0.0408 0.0488
Onchocerca volvulus 0.0057 0.0483 0.2144
Brugia malayi CHE-14 protein 0.0042 0.0329 0.0394
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0378 0.0378
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0015 0.0048 0.0044
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0218 0.1083
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1336 0.16
Mycobacterium tuberculosis Polyketide synthase Pks13 0.003 0.0211 0.0274
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1304 0.1562
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0107 0.0541
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0149
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0171 0.0204
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0096 0.0096
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0096 0.0096
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0171 0.0204
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0171 0.0204
Brugia malayi isocitrate dehydrogenase 0.0031 0.0218 0.0261
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0357 0.5
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0171 0.0834
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0271 0.0271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1304 0.1562
Loa Loa (eye worm) RNA binding protein 0.0062 0.0538 0.0644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.6957 0.6957
Mycobacterium leprae Polyketide synthase Pks13 0.003 0.0211 0.133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0378 0.0453
Leishmania major hypothetical protein, conserved 0.011 0.1028 0.5317
Onchocerca volvulus 0.0024 0.0139 0.0617
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0016 0.0066 0.0229
Mycobacterium ulcerans polyketide synthase 0.0022 0.012 0.064
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.002 0.01 0.0119
Onchocerca volvulus 0.0052 0.0428 0.19
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0938 0.1123
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0042 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0042 0.0331 0.0443
Schistosoma mansoni hypothetical protein 0.081 0.8254 0.9886
Brugia malayi Doublecortin family protein 0.0019 0.0096 0.0115
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0378 0.0378
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1304 0.1562
Echinococcus multilocularis RUN 0.0019 0.0096 0.0096
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0107 0.0541
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0218 0.2036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0653 0.0782
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0538 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0124 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0428 0.0513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0106 0.0989 0.5113
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.1923 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0139 0.0786
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0171 0.0834
Brugia malayi intermediate filament protein 0.0022 0.0124 0.0149
Onchocerca volvulus 0.0049 0.0401 0.1779
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0139 0.0786
Trichomonas vaginalis esterase, putative 0.011 0.1028 0.3545
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0013 0.0033 0.0215
Schistosoma mansoni lipoxygenase 0.0116 0.109 0.1305
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1028 0.1423
Trichomonas vaginalis helicase, putative 0.0013 0.003 0.0064
Trypanosoma cruzi oligopeptidase b 0.0042 0.0331 0.1672
Echinococcus multilocularis geminin 0.0205 0.2008 0.2008
Leishmania major cathepsin L-like protease 0.0196 0.1923 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0653 0.6317

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0168 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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