Detailed information for compound 1325610

Basic information

Technical information
  • TDR Targets ID: 1325610
  • Name: 2-[2-[(4-methylcyclohexyl)amino]-2-oxoethoxy] benzamide
  • MW: 290.357 | Formula: C16H22N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCC(CC1)NC(=O)COc1ccccc1C(=O)N
  • InChi: 1S/C16H22N2O3/c1-11-6-8-12(9-7-11)18-15(19)10-21-14-5-3-2-4-13(14)16(17)20/h2-5,11-12H,6-10H2,1H3,(H2,17,20)(H,18,19)
  • InChiKey: XUCWIONZOJWVNQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[2-[(4-methylcyclohexyl)amino]-2-oxo-ethoxy]benzamide
  • 2-[2-keto-2-[(4-methylcyclohexyl)amino]ethoxy]benzamide
  • T5308336
  • ZINC03330292
  • MLS000570668
  • SMR000150505

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0381 0.1791
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Onchocerca volvulus 0.0072 0.0736 0.127
Onchocerca volvulus 0.0021 0.0074 0.0052
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0094 0.1279
Echinococcus granulosus g protein coupled receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0052 0.0476 0.0822
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0755 0.0879
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0736 0.9043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0286 0.3891
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0158 0.0184
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0055 0.0055
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0446 0.548
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0158 0.0158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0228 0.2774 0.4788
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0446 0.6059
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0062 0.061 0.1056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0736 0.127
Echinococcus multilocularis GPCR, family 2 0.0016 0.0014 0.0014
Loa Loa (eye worm) beta-lactamase 0.0072 0.0736 0.127
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0158 0.0272
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0531 0.0531
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0288 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0736 0.0857
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0015 0 0.0003
Brugia malayi Dopamine receptor protein 2 0.0027 0.0158 0.0272
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0064 0.0074
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0259 0.3167 0.3167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0055 0.0094
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0814 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0094 0.1247
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0158 0.0184
Schistosoma mansoni cpg binding protein 0.003 0.0191 0.0222
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0288 0.5349
Echinococcus multilocularis follistatin 0.0019 0.0046 0.0046
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0021 0.0074 0.0087
Echinococcus granulosus serotonin receptor 0.0027 0.0158 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0278 0.3416
Brugia malayi calpain family protein 1 0.0054 0.0499 0.0861
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Brugia malayi nuclear receptor NHR-88 0.002 0.0055 0.0094
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0755 0.9277
Leishmania major DNA polymerase eta, putative 0.0037 0.0288 0.3816
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0005 0.0006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0158 0.0158
Echinococcus granulosus sex peptide receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0381 0.1077
Onchocerca volvulus 0.0033 0.0235 0.0348
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5175
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.101
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0158 0.0158
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0446 0.548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0055 0.0064
Schistosoma mansoni bromodomain containing protein 0.0078 0.0817 0.0952
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0436 0.5475 0.9448
Onchocerca volvulus 0.0028 0.0161 0.0211
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0057 0.0538 0.6615
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0055 0.0055
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0057 0.0538 0.0627
Onchocerca volvulus Cell death protein 3 homolog 0.012 0.1365 0.2429
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0736 0.1273
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0381 0.1077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0055 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0158 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0055 0.0055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0055 0.0064
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0381 0.1077
Toxoplasma gondii hypothetical protein 0.0027 0.0149 0.1834
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0055 0.0094
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0057 0.0538 0.6615
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0046 0.008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0158 0.0272
Onchocerca volvulus 0.0436 0.5475 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0163 0.2
Plasmodium falciparum importin beta, putative 0.0028 0.0163 0.2
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0158 0.0272
Trypanosoma cruzi protein farnesyltransferase, putative 0.0057 0.0538 0.7315
Trypanosoma cruzi protein farnesyltransferase, putative 0.0057 0.0538 0.7315
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0158 0.0184
Trypanosoma brucei unspecified product 0.0037 0.0288 0.3914
Loa Loa (eye worm) Smad1 0.0016 0.0005 0.0009
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0074 0.1377
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0074 0.101
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi putative neuropeptide receptor 0.0027 0.0158 0.0272
Entamoeba histolytica hypothetical protein 0.0023 0.0094 0.1744
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0057 0.0538 0.0538
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0755 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0053 0.0493 0.085
Brugia malayi AKH receptor 0.0027 0.0158 0.0272
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0055 0.0094
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0094 0.0266
Onchocerca volvulus 0.0037 0.0278 0.0427
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0057 0.0538 0.0627
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0158 0.0184
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0158 0.0158
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Brugia malayi Bromodomain containing protein 0.0046 0.0402 0.0694
Loa Loa (eye worm) hypothetical protein 0.0078 0.0814 0.1404
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Schistosoma mansoni adenoreceptor 0.0027 0.0158 0.0184
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0158 0.0158
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.0161 0.0161
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.091
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.6234 0.6234
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus multilocularis dna polymerase eta 0.0037 0.0288 0.0288
Schistosoma mansoni biogenic amine receptor 0.0027 0.0158 0.0184
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0067 0.0067
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0009
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0531 0.0618
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0476 0.0822
Echinococcus granulosus apoptotic protease activating factor 1 0.012 0.1365 0.159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0055 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0067 0.0823
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Entamoeba histolytica Ran family GTPase 0.0021 0.0067 0.1239
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0546 0.0636
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Loa Loa (eye worm) hypothetical protein 0.0147 0.1713 0.2956
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0158 0.0158
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0158 0.0158
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0736 0.1273
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Schistosoma mansoni calpain (C02 family) 0.002 0.0064 0.0074
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0755 0.0879
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Toxoplasma gondii exonuclease III APE 0.0037 0.0286 0.3519
Schistosoma mansoni Smad4 0.0016 0.0005 0.0006
Brugia malayi neuropeptide F receptor 0.0027 0.0158 0.0272
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0736 1
Echinococcus multilocularis serotonin receptor 0.0027 0.0158 0.0158
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0163 0.2211
Echinococcus granulosus calpain 0.002 0.0064 0.0074
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0067 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.2214 0.258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.2214 0.258
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0531 0.0618
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0736 0.1273
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0158 0.0184
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0068 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.2214 0.258
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Schistosoma mansoni hypothetical protein 0.0674 0.8581 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0464 0.0804
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.5362 0.5362
Onchocerca volvulus 0.0047 0.0407 0.0664
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0286 0.0494
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Schistosoma mansoni hypothetical protein 0.0297 0.3672 0.4279
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2774 0.2774
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0006
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0158 0.0272
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0814 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.0769
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0163 0.0163
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0055 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0278 0.0324
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni opsin-like receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Onchocerca volvulus 0.0027 0.0158 0.0206
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0158 0.0184
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0814 0.0948
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0158 0.0158
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni cpg binding protein 0.0034 0.0243 0.0283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0761 0.0761
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0476 0.0822
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0021 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus GPCR family 2 0.0016 0.0014 0.0016
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0161 0.0277
Schistosoma mansoni bhlhzip transcription factor bigmax 0.046 0.5794 0.6753
Brugia malayi calpain 7 0.002 0.0064 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0158
Echinococcus multilocularis cpg binding protein 0.0034 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.012 0.1365 0.2355
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0158 0.0184
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0158 0.0184
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0055 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0736 0.2082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni calpain C (C02 family) 0.002 0.0064 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0137 0.1856
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0055 0.0094
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0286 0.0495
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0736 0.1273
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0055 0.0064
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Echinococcus granulosus neuropeptide receptor 0.0027 0.0158 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0055 0.0094
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0823
Schistosoma mansoni organic anion transporter 0.0028 0.0161 0.0187
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0288 0.3914
Leishmania major lanosterol synthase, putative 0.0047 0.041 0.5428
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0184
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0158 0.0272
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0009
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus multilocularis hypothetical protein 0.002 0.0064 0.0064
Echinococcus multilocularis serotonin receptor 0.0027 0.0158 0.0158
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0736 0.8524
Brugia malayi hypothetical protein 0.0032 0.0217 0.0374
Onchocerca volvulus 0.0028 0.0161 0.0211
Echinococcus granulosus neuropeptide s receptor 0.0494 0.6234 0.7265
Leishmania major GTP-binding protein, putative 0.0021 0.0067 0.0887
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Onchocerca volvulus 0.0287 0.3533 0.6423
Loa Loa (eye worm) calpain 0.002 0.0064 0.011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0158 0.0184
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0288 0.0497
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0078 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0546 0.0636
Brugia malayi beta-lactamase 0.0072 0.0736 0.127
Schistosoma mansoni coup transcription factor 0.002 0.0055 0.0064
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0177 0.0206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0288 0.0498
Trypanosoma brucei unspecified product 0.0026 0.0137 0.1856
Brugia malayi RE15519p 0.0027 0.0158 0.0272
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0288 0.0288
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0158 0.0184
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Schistosoma mansoni hypothetical protein 0.0051 0.0459 0.0535
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0158 0.0158
Mycobacterium ulcerans hypothetical protein 0.0072 0.0736 0.8524
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0464 0.0804
Brugia malayi GnHR receptor homolog 0.0027 0.0158 0.0272
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Brugia malayi SPARC precursor 0.0019 0.0046 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0736 1
Schistosoma mansoni follistatin 0.0019 0.0046 0.0054
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0041 0.0338 0.4154
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0015 0 0.0003
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0021 0.0074 0.021
Schistosoma mansoni inhibitor of apoptosis protein 0.0436 0.5475 0.638
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Echinococcus multilocularis apoptotic protease activating factor 1 0.012 0.1365 0.1365
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0158 0.0272
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0014 0.0024
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0015 0 0.0003
Mycobacterium tuberculosis Conserved protein 0.0072 0.0736 0.1273
Schistosoma mansoni opsin-like receptor 0.0027 0.0158 0.0184
Brugia malayi Melatonin receptor type 1A 0.0027 0.0158 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0074 0.101
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0046 0.0569
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0381 0.1791
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0286 0.0334
Onchocerca volvulus Deterin homolog 0.0436 0.5475 1
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0064 0.0074
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0843
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.032 0.0554
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0646 0.0752
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0158 0.0272
Trypanosoma brucei unspecified product 0.0026 0.0137 0.1856
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0021 0.0074 0.0087
Schistosoma mansoni hypothetical protein 0.0018 0.0041 0.0047
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0814 1
Brugia malayi ORL1-like opioid receptor 0.0027 0.0158 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0736 1
Echinococcus multilocularis calpain 5 0.002 0.0064 0.0064
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0064 0.0074
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0158 0.0272
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0094 0.0266
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0161 0.0211
Echinococcus granulosus caspase 2 0.012 0.1365 0.159
Leishmania major hypothetical protein, conserved 0.005 0.0446 0.5907
Leishmania major DNA polymerase kappa, putative 0.0037 0.0288 0.3816
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0158 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0021 0.0074 0.1377
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0022 0.009 0.0104
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0158 0.0272
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.2813 0.4855
Giardia lamblia DINP protein human, muc B family 0.0037 0.0288 0.5349
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0736 0.1273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Plasmodium vivax calpain, putative 0.002 0.0064 0.0782
Mycobacterium tuberculosis Conserved protein 0.0072 0.0736 0.1273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.2214 0.2214
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0016
Loa Loa (eye worm) inositol-1 0.0045 0.0381 0.0657
Schistosoma mansoni histamine h1 receptor 0.0027 0.0158 0.0184
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0288 0.0336
Brugia malayi Dopamine receptor 0.0027 0.0158 0.0272
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.2214 0.382
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0074 0.101
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0288 0.0814
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0814 1
Brugia malayi larval opioid receptor 0.0027 0.0158 0.0272
Echinococcus granulosus dna polymerase eta 0.0037 0.0288 0.0336
Schistosoma mansoni inositol monophosphatase 0.0045 0.0381 0.0444
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0286 0.5317
Toxoplasma gondii ABC1 family protein 0.0072 0.0736 0.9043
Brugia malayi nuclear hormone receptor 0.002 0.0055 0.0094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0755 0.8884
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3672 0.6337
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0158 0.0184
Mycobacterium ulcerans lipase LipD 0.0072 0.0736 0.8524
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0407 0.0702
Loa Loa (eye worm) hypothetical protein 0.0085 0.0912 0.1574
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0021 0.0074 0.0074
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0021 0.0074 0.0914
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0055 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0137 0.1856
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.2214 0.382
Echinococcus multilocularis snurportin 1 0.0297 0.3672 0.3672
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0594 0.7306
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0055 0.0064
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi calpain family protein 1 0.0054 0.0499 0.0861
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0453
Brugia malayi Dopamine receptor protein 1 0.0027 0.0158 0.0272
Echinococcus granulosus calpain A 0.0056 0.0531 0.0618
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0158 0.0158
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0158 0.0184
Onchocerca volvulus 0.0028 0.0161 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0365 0.0365
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0158 0.0272
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0158 0.0158
Echinococcus granulosus importin subunit beta 1 0.0028 0.0163 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0128
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0158 0.0184
Plasmodium vivax SET domain protein, putative 0.0037 0.0278 0.3416
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0055 0.0064
Echinococcus granulosus follistatin 0.0019 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Schistosoma mansoni myosin xvIII 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0497
Schistosoma mansoni hypothetical protein 0.0025 0.0124 0.0145
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0262 0.0453
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0464 0.4744
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0381 0.7073
Echinococcus multilocularis calpain A 0.0056 0.0531 0.0531
Echinococcus granulosus somatostatin receptor 0.0027 0.0158 0.0184
Brugia malayi PHD-finger family protein 0.0032 0.0214 0.0369
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Leishmania major farnesyltransferase beta subunit 0.0057 0.0538 0.7131
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0191 0.0329
Onchocerca volvulus 0.0027 0.0158 0.0206
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0736 0.127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni DNA polymerase eta 0.0037 0.0288 0.0336
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0427 0.5362 0.6249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni ran 0.0021 0.0067 0.0078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0055 0.0064
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0562 0.0655
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0057 0.0538 0.1523
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0158 0.0184
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0158 0.0184
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0057 0.0538 0.1523
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0158 0.0158
Onchocerca volvulus 0.0027 0.0158 0.0206
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0736 0.2082
Schistosoma mansoni ap endonuclease 0.0037 0.0286 0.0334
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0055 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0055 0.0094
Schistosoma mansoni ran 0.0021 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0436 0.5475 0.9448
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0761 0.0887
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0499 0.0861
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0024
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0158 0.0184
Trichomonas vaginalis esterase, putative 0.0072 0.0736 0.2082
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0021 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0055 0.0094
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus calpain A 0.002 0.0064 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0406
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0016
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0021 0.0074 0.0087
Echinococcus granulosus orexin receptor type 2 0.0027 0.0158 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0015 0 0.0003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0755 0.0755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0055 0.0094
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0055 0.0094
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0158 0.0272
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0288 0.0497
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0055 0.0015
Echinococcus granulosus g protein coupled receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Trichomonas vaginalis ran, putative 0.0021 0.0067 0.0189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0736 0.0736
Schistosoma mansoni organic anion transporter 0.0028 0.0161 0.0187
Loa Loa (eye worm) hypothetical protein 0.0046 0.0403 0.0696
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0055 0.0064
Trypanosoma cruzi MFS transporter, putative 0.0028 0.0161 0.2184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0055 0.0094
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0286 0.5317
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.032 0.2569
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0288 0.0498
Echinococcus granulosus smad 0.0016 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0736 0.1273
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0158 0.0184
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0436 0.5475 0.638
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Onchocerca volvulus 0.0028 0.0161 0.0211
Brugia malayi MH2 domain containing protein 0.0231 0.2813 0.4855
Echinococcus multilocularis agrin 0.0019 0.0046 0.0046
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0158 0.0206
Echinococcus granulosus fmrfamide receptor 0.0027 0.0158 0.0184
Brugia malayi sulfakinin receptor protein 0.0027 0.0158 0.0272
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0055 0.0015
Schistosoma mansoni hypothetical protein 0.0674 0.8581 1
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Bromodomain containing protein 0.0092 0.1001 0.1728
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0055 0.0094
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0158 0.0184
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0074 0.1377
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0057 0.0538 0.1523
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0137 0.1856
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0158 0.0158
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0436 0.5475 0.9448
Brugia malayi steroid hormone receptor 0.002 0.0055 0.0094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.6234 0.7265
Echinococcus granulosus FTZ F1 alpha 0.002 0.0055 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0446 0.548
Trypanosoma brucei antigen, putative 0.002 0.0064 0.0865
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0055 0.0055
Brugia malayi ecdysteroid receptor 0.002 0.0055 0.0094
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0288 0.3914
Schistosoma mansoni inositol monophosphatase 0.0045 0.0381 0.0444
Brugia malayi Serotonin receptor 0.0027 0.0158 0.0272
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0531 0.0618
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0736 0.2082
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0021 0.0074 0.0914
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0446 0.548
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Leishmania major hypothetical protein, conserved 0.0072 0.0736 0.9748
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0286 0.3519
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Brugia malayi hypothetical protein 0.0147 0.1713 0.2956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0115
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0446 0.6059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0365 0.0425
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0259 0.3167 0.369
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.012 0.1365 0.2355
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0736 0.2082
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0057 0.0538 0.0929
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0057 0.0538 0.1523
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0381 0.0381
Schistosoma mansoni smad 0.0016 0.0005 0.0006
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.0161 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0 0.0003
Brugia malayi G protein-coupled receptor 0.0027 0.0158 0.0272
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3533 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0755 0.8884
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0161 0.1975
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Echinococcus granulosus cpg binding protein 0.0034 0.0243 0.0283
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.1239
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0286 0.3519
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0259 0.3167 0.369
Brugia malayi hypothetical protein 0.005 0.0446 0.0769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0055 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0057 0.0538 0.0929
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi RNA, U transporter 1 0.0079 0.0831 0.1435
Brugia malayi G-protein coupled receptor 0.0027 0.0158 0.0272
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0005 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0546 0.0636
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Echinococcus multilocularis zinc finger protein 0.0025 0.013 0.013
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 0.5
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.5778 1
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.6234 0.6234
Trypanosoma cruzi ISWI complex protein 0.0018 0.0041 0.0551
Loa Loa (eye worm) hypothetical protein 0.0057 0.0546 0.0942
Onchocerca volvulus 0.0028 0.0161 0.0211
Loa Loa (eye worm) hypothetical protein 0.0049 0.0441 0.076
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0381 0.468
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.046 0.5794 1
Echinococcus multilocularis somatostatin receptor 0.0027 0.0158 0.0158
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0288 0.0497
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0184
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0158
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0074 0.101
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.009 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0055 0.0094
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0055 0.0055
Schistosoma mansoni zinc finger protein 0.0025 0.013 0.0152
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0161 0.0211
Brugia malayi hypothetical protein 0.0228 0.2774 0.4788
Echinococcus granulosus geminin 0.0674 0.8581 1
Echinococcus multilocularis sex peptide receptor 0.0027 0.0158 0.0158
Brugia malayi hypothetical protein 0.012 0.1365 0.2355
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0286 0.3891
Loa Loa (eye worm) calpain family protein 1 0.004 0.0315 0.0543
Onchocerca volvulus 0.003 0.0191 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0158 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0286 0.081
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0055 0.0055
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0158 0.0206
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0755 0.0879
Echinococcus granulosus agrin 0.0019 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0015 0 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.2813 0.4855
Schistosoma mansoni thyroid hormone receptor 0.002 0.0055 0.0064
Echinococcus granulosus max protein X 0.046 0.5794 0.6753
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0055 0.0064
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0278 0.0278
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Schistosoma mansoni hypothetical protein 0.0436 0.5475 0.638
Mycobacterium tuberculosis Conserved protein 0.0072 0.0736 0.1273
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0288 0.3914
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.0985
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0161 0.0277
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0074 0.101
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.0161 0.0277
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0055 0.0055
Brugia malayi CXXC zinc finger family protein 0.003 0.0191 0.0329
Echinococcus multilocularis smad 0.0016 0.0005 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0158 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0055 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Leishmania major geranylgeranyltransferase, putative 0.0015 0 0.0003
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0163 0.2211
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0724
Echinococcus granulosus neuropeptide receptor 0.0027 0.0158 0.0184
Onchocerca volvulus 0.0027 0.0158 0.0206
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0288 0.3816
Leishmania major hypothetical protein, conserved 0.0018 0.0041 0.0537
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0006
Echinococcus granulosus allatostatin A receptor 0.0027 0.0158 0.0184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0476 0.0822
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.101
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0149 0.1834
Echinococcus granulosus Smad4 0.0016 0.0005 0.0006
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0158 0.0184
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0055 0.0064
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0064 0.0865
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus multilocularis caspase 2 0.012 0.1365 0.1365
Brugia malayi neuropeptide F receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Echinococcus granulosus hypothetical protein 0.0027 0.0158 0.0184
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0055 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0158 0.0158
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0161 0.0277
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.101
Brugia malayi hypothetical protein 0.0028 0.0161 0.0277
Echinococcus multilocularis Smad4 0.0016 0.0005 0.0005
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0158 0.0158
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0158 0.0158
Echinococcus granulosus dnaJ subfamily B 0.0427 0.5362 0.6249
Brugia malayi Pre-SET motif family protein 0.0252 0.3081 0.5317
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0015 0 0.0003
Onchocerca volvulus 0.0027 0.0158 0.0206
Schistosoma mansoni hypothetical protein 0.0036 0.0262 0.0306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0158 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0446 0.6059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0055 0.0094
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0814 0.0948
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 0.5
Brugia malayi beta-lactamase family protein 0.0072 0.0736 0.127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.2214 0.258
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Mycobacterium ulcerans beta-lactamase 0.0072 0.0736 0.8524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0252 0.0294
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0158 0.0158
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0158 0.0158
Echinococcus multilocularis calpain 0.002 0.0064 0.0064
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0158 0.0158
Echinococcus granulosus snurportin 1 0.0297 0.3672 0.4279
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.091
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0005 0.0006
Trypanosoma brucei ISWI complex protein 0.0018 0.0041 0.0551
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0158 0.0184
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.1377
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0055 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0542 0.6853 0.7987
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0158 0.0184
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni zinc finger protein 0.0018 0.0041 0.0047
Schistosoma mansoni hypothetical protein 0.0047 0.0407 0.0474
Echinococcus multilocularis geminin 0.0674 0.8581 0.8581
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0158 0.0272
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0068 0.0068
Onchocerca volvulus 0.0072 0.0736 0.127
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0158 0.0272
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0158 0.0158
Brugia malayi Pre-SET motif family protein 0.0037 0.0278 0.048
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0158 0.0272
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0055 0.0094
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0158 0.0158
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0161 0.0211
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0177 0.0206
Brugia malayi Cell death protein 3 precursor 0.012 0.1365 0.2355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0736 0.8524
Echinococcus granulosus inhibitor of apoptosis protein 0.0436 0.5475 0.638
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0286 0.3793
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0158 0.0184
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0068 0.0079
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0436 0.5475 0.5475
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0057 0.0538 0.1523
Brugia malayi Importin beta-1 subunit 0.0028 0.0163 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.2214 0.2214
Schistosoma mansoni ap endonuclease 0.0037 0.0286 0.0334
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0755 0.8884
Trypanosoma cruzi ISWI complex protein 0.0018 0.0041 0.0551
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Brugia malayi beta-lactamase family protein 0.0072 0.0736 0.127
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0158 0.0272
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Toxoplasma gondii hypothetical protein 0.0021 0.0074 0.0914
Onchocerca volvulus 0.012 0.1365 0.2429
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0046 0.008
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0436 0.5475 0.638
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0278 0.0324
Schistosoma mansoni biogenic amine receptor 0.0027 0.0158 0.0184
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0288 0.3914
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0464 0.0464
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0158 0.0184
Brugia malayi Serotonin receptor 0.0027 0.0158 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0 0.0003
Schistosoma mansoni bhlhzip transcription factor bigmax 0.046 0.5794 0.6753
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0068 0.0079
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.009 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0055 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi G-protein coupled receptor 0.0027 0.0158 0.0272
Brugia malayi Probable ClpP-like protease 0.0078 0.0814 0.1404
Trypanosoma cruzi lanosterol synthase, putative 0.0062 0.061 0.829
Brugia malayi prostaglandin transporter 0.0028 0.0161 0.0277
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0464 0.0541
Schistosoma mansoni cpg binding protein 0.0034 0.0243 0.0283
Loa Loa (eye worm) hypothetical protein 0.0054 0.0499 0.0861
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Schistosoma mansoni survival motor neuron protein 0.0047 0.0407 0.0474
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0736 0.0857
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0067 0.0823
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0158 0.0184
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0021 0.0074 0.0914
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0149 0.1834
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0288 0.0336
Loa Loa (eye worm) hypothetical protein 0.0436 0.5475 0.9448
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0158 0.0158
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0843
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2774 0.3233
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Schistosoma mansoni importin beta-1 0.0028 0.0163 0.019
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0814 0.0814
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0736 0.0857
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0115
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0158 0.0158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0546 0.0546
Echinococcus granulosus calpain 7 C02 family 0.002 0.0064 0.0074
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0543
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0736 0.8828
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Mycobacterium leprae Probable lipase LipE 0.0072 0.0736 0.8828
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0288 0.0814
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.0281
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0499 0.0581
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3081 0.5317
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0843
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0055 0.0064
Echinococcus multilocularis expressed protein 0.0019 0.0046 0.0046
Echinococcus multilocularis inhibitor of apoptosis protein 0.0436 0.5475 0.5475
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Schistosoma mansoni hypothetical protein 0.012 0.1365 0.159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0014 0.0024
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0288 0.0288
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.1365 0.159
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Echinococcus granulosus dna polymerase kappa 0.0037 0.0288 0.0336
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0177 0.0177
Echinococcus multilocularis max protein X 0.046 0.5794 0.5794
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0286 0.0286
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0755 0.1306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0057 0.0538 1
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0021 0.0074 0.0087
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0286 0.0494
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0736 0.2082
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.091
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0286 0.081
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0158 0.0158
Schistosoma mansoni thyroid hormone receptor 0.002 0.0055 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Schistosoma mansoni biogenic amine receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0124 0.0215
Brugia malayi Inositol-1 0.0045 0.0381 0.0657
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0381 0.0444
Trypanosoma cruzi lanosterol synthase, putative 0.0062 0.061 0.829
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0057 0.0538 0.7315
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Onchocerca volvulus 0.0027 0.0158 0.0206
Giardia lamblia Prenyltransferase 0.0057 0.0538 1
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0288 0.0032
Echinococcus granulosus zinc finger protein 0.0025 0.013 0.0152
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0736 0.1273
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0005 0.0005
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.046 0.5794 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0158 0.0158
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0055 0.0094
Echinococcus granulosus calpain 5 0.002 0.0064 0.0074
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Plasmodium vivax geranylgeranyltransferase, putative 0.0015 0 0.0003
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.021
Onchocerca volvulus 0.002 0.0055 0.0015
Echinococcus granulosus g protein coupled receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0005 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0055 0.0094
Onchocerca volvulus 0.0027 0.0158 0.0206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0074 0.101
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0542 0.6853 0.6853
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0158 0.0184
Brugia malayi Smad1 0.0016 0.0005 0.0009
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0286 0.2064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Brugia malayi hypothetical protein 0.0028 0.0161 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5175
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0094 0.0266
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0057 0.0538 0.6615
Onchocerca volvulus 0.0027 0.0158 0.0206
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0163 0.2
Schistosoma mansoni nuclear hormone receptor 0.002 0.0055 0.0064
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.0161 0.0187
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0021 0.0074 0.0914
Schistosoma mansoni opsin-like receptor 0.0027 0.0158 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0286 0.3891
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma brucei lanosterol synthase 0.0062 0.061 0.829
Schistosoma mansoni agrin 0.0019 0.0046 0.0054
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.2214 0.258
Onchocerca volvulus 0.0072 0.0736 0.127
Onchocerca volvulus 0.0147 0.1713 0.3071
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0158 0.0184
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0057 0.0538 0.1523
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0158 0.0272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Plasmodium falciparum geranylgeranyltransferase, putative 0.0015 0 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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