Detailed information for compound 1334647

Basic information

Technical information
  • TDR Targets ID: 1334647
  • Name: 1,3-dioxo-N-(phenylmethyl)-2-(pyridin-3-ylmet hyl)isoindole-5-carboxamide
  • MW: 371.389 | Formula: C22H17N3O3
  • H donors: 1 H acceptors: 4 LogP: 2.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)C(=O)N(C2=O)Cc1cccnc1)NCc1ccccc1
  • InChi: 1S/C22H17N3O3/c26-20(24-13-15-5-2-1-3-6-15)17-8-9-18-19(11-17)22(28)25(21(18)27)14-16-7-4-10-23-12-16/h1-12H,13-14H2,(H,24,26)
  • InChiKey: GJKCJJLUOJOWIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dioxo-N-(phenylmethyl)-2-(3-pyridylmethyl)isoindoline-5-carboxamide
  • 1,3-dioxo-N-(phenylmethyl)-2-(3-pyridylmethyl)-5-isoindolinecarboxamide
  • N-(benzyl)-1,3-diketo-2-(3-pyridylmethyl)isoindoline-5-carboxamide
  • ZINC00692953
  • AN-979/41972032
  • STK266436

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0221 0.1256 0.19
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0876 0.5194 0.5178
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0073 0.004
Giardia lamblia DINP protein human, muc B family 0.0019 0.0041 0.0014
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0221 0.1256 0.19
Trypanosoma brucei unspecified product 0.0019 0.0041 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1701 0.2586
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0199 0.0165
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0041 0.0041
Echinococcus multilocularis acetylcholinesterase 0.1675 1 1
Loa Loa (eye worm) beta-lactamase 0.0039 0.0161 0.0161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.026 0.0227
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0221 0.1256 0.2359
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0037 0.0003
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0153 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0197 0.1114 0.1114
Mycobacterium tuberculosis Conserved protein 0.0039 0.0161 0.0234
Brugia malayi cyclic AMP-response element binding protein 1 gamma 1, putative 0.0211 0.1197 0.117
Echinococcus multilocularis lipoxygenase domain containing protein 0.0077 0.0392 0.036
Echinococcus granulosus neuroligin 0.0283 0.1629 0.1601
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0161 0.0128
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0876 0.5194 0.7978
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0177 0.0233
Loa Loa (eye worm) hypothetical protein 0.0078 0.0396 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.006 0.0031
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0221 0.1256 0.2359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0037 0.0037
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1094 0.6505 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0767 0.1144
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0876 0.5194 0.5178
Brugia malayi hypothetical protein 0.0077 0.0392 0.0363
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0283 0.1629 0.1629
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0041 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0054 0.025 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.026
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0034 0.0043
Schistosoma mansoni hypothetical protein 0.0043 0.0189 0.0189
Brugia malayi beta-lactamase 0.0039 0.0161 0.0132
Brugia malayi nuclear hormone receptor 0.0022 0.006 0.0031
Schistosoma mansoni hypothetical protein 0.0077 0.0392 0.0392
Plasmodium falciparum LCCL domain-containing protein 0.0077 0.0392 0.06
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0221 0.1256 0.1227
Plasmodium vivax multidomain scavenger receptor, putative 0.0077 0.0392 0.06
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0073 0.0074
Schistosoma mansoni high-affinity choline transporter 0.0339 0.1969 0.1969
Echinococcus multilocularis GPCR, family 2 0.0054 0.025 0.0217
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.006 0.0031
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0876 0.5194 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1012 0.1012
Trypanosoma cruzi polyprenyl synthase, putative 0.0221 0.1256 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0199 0.032
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0283 0.1629 0.1601
Loa Loa (eye worm) hypothetical protein 0.0339 0.1969 0.1969
Schistosoma mansoni nuclear hormone receptor 0.0022 0.006 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0034 0.0034
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0221 0.1256 1
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0221 0.1256 0.123
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0283 0.1629 0.1629
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.0324
Echinococcus granulosus solute carrier family 5 0.0037 0.0153 0.0119
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0221 0.1256 0.1227
Schistosoma mansoni hypothetical protein 0.0043 0.0189 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0174
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0034 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1701 0.2586
Brugia malayi GH02984p 0.0339 0.1969 0.1945
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0077 0.0392 0.0392
Schistosoma mansoni lipoxygenase 0.0323 0.187 0.187
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0221 0.1256 1
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.2981 0.2958
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.006 0.0027
Echinococcus granulosus GPCR family 2 0.0054 0.025 0.0217
Schistosoma mansoni rab6-interacting 0.0077 0.0392 0.0392
Echinococcus granulosus zinc finger protein 0.0028 0.0098 0.0065
Schistosoma mansoni BC026374 protein (S09 family) 0.0283 0.1629 0.1629
Schistosoma mansoni gliotactin 0.0283 0.1629 0.1629
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0041 0.0054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0356 0.0323
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0073 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0559 0.0527
Echinococcus multilocularis protein dispatched 1 0.0051 0.0237 0.0204
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0876 0.5194 1
Leishmania major hypothetical protein, conserved 0.0026 0.0086 0.0093
Echinococcus multilocularis zinc finger protein 0.0028 0.0098 0.0065
Schistosoma mansoni patched 1 0.0045 0.0199 0.0199
Loa Loa (eye worm) polyprenyl synthetase 0.0876 0.5194 0.5194
Schistosoma mansoni hypothetical protein 0.0043 0.0189 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0161 0.0148
Leishmania major polyprenyl synthase, putative 0.0221 0.1256 0.19
Schistosoma mansoni acetylcholinesterase 0.0283 0.1629 0.1629
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.006 0.0027
Onchocerca volvulus 0.0077 0.0392 0.2114
Echinococcus granulosus dna polymerase kappa 0.0019 0.0041 0.0007
Trichomonas vaginalis esterase, putative 0.0039 0.0161 0.0248
Echinococcus granulosus histone acetyltransferase KAT2B 0.0297 0.1716 0.1688
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1444 0.2733
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0199 0.0199
Entamoeba histolytica hypothetical protein 0.0081 0.0415 0.312
Onchocerca volvulus 0.0283 0.1629 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0084 0.043 0.0402
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1094 0.6505 0.6494
Mycobacterium ulcerans carboxylesterase, LipT 0.0283 0.1629 0.3083
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1444 0.2733
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.006 0.0027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0161
Echinococcus granulosus RUN 0.0077 0.0392 0.036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0037 0.0037
Echinococcus multilocularis expressed conserved protein 0.0099 0.0521 0.0489
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0322 0.0559
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0086 0.0086
Trypanosoma brucei C-8 sterol isomerase, putative 0.1094 0.6505 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.006 0.0031
Loa Loa (eye worm) carboxylesterase 0.1675 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0559 0.4298
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0034 0.0012
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0075 0.0381 0.0381
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.006 0.0027
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0034 0.0012
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0221 0.1256 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0161 0.0234
Echinococcus granulosus lipoxygenase domain containing protein 0.0077 0.0392 0.036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.006 0.0031
Onchocerca volvulus Huntingtin homolog 0.0263 0.1512 0.925
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0221 0.1256 0.1227
Mycobacterium ulcerans hypothetical protein 0.0039 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0169 0.0946 0.0946
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.026 0.0227
Leishmania major DNA polymerase kappa, putative 0.0019 0.0041 0.0023
Echinococcus multilocularis lipoxygenase domain containing protein 0.0077 0.0392 0.036
Echinococcus granulosus tyrosine protein kinase ABL1 0.0205 0.1161 0.1132
Schistosoma mansoni survival motor neuron protein 0.0104 0.055 0.055
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0221 0.1256 0.1256
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0559 0.0527
Echinococcus multilocularis RUN 0.0077 0.0392 0.036
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0199 0.0165
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0161 0.0234
Onchocerca volvulus 0.0211 0.1197 0.7242
Leishmania major C-8 sterol isomerase-like protein 0.1094 0.6505 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.006 0.0031
Schistosoma mansoni loxhd1 0.0077 0.0392 0.0392
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0034 0.0034
Mycobacterium ulcerans beta-lactamase 0.0039 0.0161 0.0234
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0876 0.5194 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0944 0.5605 0.559
Schistosoma mansoni hypothetical protein 0.0054 0.025 0.025
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0072 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.006 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0322 0.0322
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0862 0.1593
Schistosoma mansoni hypothetical protein 0.0197 0.1114 0.1114
Echinococcus granulosus expressed conserved protein 0.0099 0.0521 0.0489
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.026 0.0231
Onchocerca volvulus 0.0283 0.1629 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0161
Echinococcus granulosus BC026374 protein S09 family 0.0283 0.1629 0.1601
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0484 0.0452
Loa Loa (eye worm) hypothetical protein 0.0559 0.3289 0.3289
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0424 0.3189
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0876 0.5194 0.7978
Echinococcus multilocularis protein patched 0.0045 0.0199 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0041 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.026 0.0227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0161 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0086 0.0093
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0199 0.0165
Echinococcus granulosus acetylcholinesterase 0.1675 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0177 0.0233
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0177 0.0263
Brugia malayi Latrophilin receptor protein 2 0.0054 0.025 0.0221
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0161 0.0128
Schistosoma mansoni zinc finger protein 0.0016 0.0026 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0041 0.0054
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0116 0.0624 0.0624
Brugia malayi PHD-finger family protein 0.0034 0.0132 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0231 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0169 0.0946 0.0919
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.083 0.0799
Schistosoma mansoni hypothetical protein 0.0054 0.025 0.025
Brugia malayi acetyltransferase, GNAT family protein 0.0309 0.1783 0.1759
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0221 0.1256 0.2359
Brugia malayi nuclear receptor NHR-88 0.0022 0.006 0.0031
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0161 0.0161
Brugia malayi Carboxylesterase family protein 0.0283 0.1629 0.1604
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0322 0.0289
Loa Loa (eye worm) hypothetical protein 0.0092 0.0481 0.0481
Schistosoma mansoni glutathione synthetase 0.0221 0.1256 0.1256
Schistosoma mansoni hypothetical protein 0.0022 0.006 0.006
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0153 0.0119
Loa Loa (eye worm) polyprenyl synthetase 0.0221 0.1256 0.1256
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0876 0.5194 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0041 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0322 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0322 0.0546
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0283 0.1629 0.1601
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0158 0.0125
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0053 0.0042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0041 0.0023
Trypanosoma cruzi polyprenyl synthase, putative 0.0221 0.1256 0.19
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0041 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.006 0.006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1675 1 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.1197 0.1197
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0041 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Trichomonas vaginalis spcc417.12 protein, putative 0.0283 0.1629 0.3092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.055 0.0522
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0309 0.1783 0.1755
Brugia malayi latrophilin 2 splice variant baaae 0.0116 0.0624 0.0596
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0158 0.0125
Schistosoma mansoni hypothetical protein 0.0104 0.055 0.055
Echinococcus multilocularis microtubule associated protein 2 0.1436 0.8565 0.856
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0876 0.5194 1
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.083 0.0799
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0356 0.0323
Loa Loa (eye worm) hypothetical protein 0.0508 0.2981 0.2981
Brugia malayi hypothetical protein 0.0283 0.1629 0.1604
Loa Loa (eye worm) carboxylesterase 0.0283 0.1629 0.1629
Echinococcus multilocularis muscleblind protein 0.018 0.1012 0.0982
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0559 0.0531
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0037 0.0037
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1701 0.2609
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.006 0.006
Brugia malayi ecdysteroid receptor 0.0022 0.006 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.0415 0.0383
Echinococcus granulosus muscleblind protein 0.018 0.1012 0.0982
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0037 0.0037
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0054 0.025 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0177 0.0233
Brugia malayi Doublecortin family protein 0.0077 0.0392 0.0363
Schistosoma mansoni polycystin 1-related 0.0077 0.0392 0.0392
Schistosoma mansoni neuroligin 3 (S09 family) 0.0283 0.1629 0.1629
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0976 0.1826
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.006 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.0415 0.0383
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0322 0.0457
Brugia malayi steroid hormone receptor 0.0022 0.006 0.0031
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0153 0.0119
Loa Loa (eye worm) hypothetical protein 0.0051 0.0234 0.0234
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0041 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.006 0.006
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0073 0.0104
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0221 0.1256 0.237
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1444 0.1419
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0876 0.5194 0.5194
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.006 0.0027
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.0676 0.0648
Echinococcus multilocularis geminin 0.0197 0.1114 0.1084
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0034 0.0012
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0221 0.1256 0.1925
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0322 0.0546
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0012
Schistosoma mansoni bromodomain containing protein 0.0075 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0092 0.0481 0.0481
Mycobacterium tuberculosis Carboxylesterase LipT 0.0283 0.1629 0.3083
Loa Loa (eye worm) hypothetical protein 0.0263 0.1512 0.1512
Echinococcus granulosus microtubule associated protein 2 0.1436 0.8565 0.856
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0153 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.006 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0169 0.0946 0.0946
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0041 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0161 0.0248
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0034 0.0013
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.006 0.006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0283 0.1629 0.1629
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0283 0.1629 0.3092
Leishmania major solanesyl-diphosphate synthase, putative 0.0221 0.1256 0.19
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0037 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.006 0.006
Brugia malayi Polyprenyl synthetase family protein 0.0876 0.5194 0.518
Mycobacterium ulcerans lipase LipD 0.0039 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.018 0.1012 0.1012
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0221 0.1256 0.2292
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0034 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.006 0.006
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0153 0.0123
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0876 0.5194 1
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0923 0.5495
Schistosoma mansoni eyes absent homolog 0.0092 0.0481 0.0481
Echinococcus granulosus Polycystic kidney disease protein 0.0077 0.0392 0.036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0073 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0041 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0161 0.0248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0153
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0043 0.0189 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1444 0.2733
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0221 0.1256 0.1256
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0161 0.0248
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0221 0.1256 0.5
Schistosoma mansoni sodium/solute symporter 0.0037 0.0153 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0004
Toxoplasma gondii ABC1 family protein 0.0039 0.0161 0.0248
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0161 0.0234
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.006 0.0027
Echinococcus multilocularis tyrosine protein kinase Abl 0.0084 0.043 0.0398
Echinococcus multilocularis muscleblind protein 1 0.018 0.1012 0.0982
Onchocerca volvulus 0.0283 0.1629 1
Leishmania major hypothetical protein, conserved 0.0039 0.0161 0.021
Loa Loa (eye worm) hypothetical protein 0.0053 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Schistosoma mansoni lipoxygenase 0.0462 0.2706 0.2706
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0086 0.0093
Schistosoma mansoni zinc finger protein 0.0028 0.0098 0.0098
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0161 0.0248
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.1422 0.268
Brugia malayi hypothetical protein 0.0026 0.0086 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0161
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0034 0.0012
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0034 0.0043
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0161 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1444 0.2733
Brugia malayi Carboxylesterase family protein 0.0283 0.1629 0.1604
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.006 0.0031
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0221 0.1256 0.2292
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0054 0.025 0.0217
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0077 0.0392 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.006 0.0031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0034 0.0013
Loa Loa (eye worm) carboxylesterase 0.0283 0.1629 0.1629
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0205 0.1161 0.1132
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0034 0.0034
Echinococcus granulosus para nitrobenzyl esterase 0.0283 0.1629 0.1601
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0221 0.1256 0.2359
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0283 0.1629 0.3083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0462 0.2706 0.2682
Schistosoma mansoni hypothetical protein 0.0081 0.0415 0.0415
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0026
Echinococcus granulosus geminin 0.0197 0.1114 0.1084
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0161 0.021
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0876 0.5194 0.7984
Echinococcus granulosus high affinity choline transporter 1 0.0339 0.1969 0.1942
Echinococcus granulosus lipoxygenase domain containing protein 0.0077 0.0392 0.036
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.0415 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Loa Loa (eye worm) hypothetical protein 0.0105 0.0559 0.0559
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0221 0.1256 0.19
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Brugia malayi Polyprenyl synthetase family protein 0.0221 0.1256 0.123
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0153 0.0119
Brugia malayi Carboxylesterase family protein 0.1675 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0569 0.0569
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0161 0.0234
Onchocerca volvulus 0.0039 0.0161 0.0644
Giardia lamblia Farnesyl diphosphate synthase 0.0876 0.5194 1
Leishmania major farnesyl pyrophosphate synthase 0.0876 0.5194 0.7978
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0161 0.024
Echinococcus multilocularis neuroligin 0.0283 0.1629 0.1601
Onchocerca volvulus 0.0283 0.1629 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0041 0.0007
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0221 0.1256 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.006 0.0027
Echinococcus granulosus carboxylesterase 5A 0.1675 1 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.006 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0161 0.0248
Brugia malayi Bromodomain containing protein 0.0088 0.0454 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.006 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.006 0.006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0767 0.1144
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0322 0.0546
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.006 0.0031
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0221 0.1256 0.1227
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Loa Loa (eye worm) latrophilin receptor protein 2 0.0054 0.025 0.025
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0424 0.0661
Mycobacterium ulcerans hypothetical protein 0.0155 0.0862 0.1593
Onchocerca volvulus 0.0104 0.055 0.3123
Trypanosoma brucei ISWI complex protein 0.0016 0.0026 0.0031
Entamoeba histolytica hypothetical protein 0.0081 0.0415 0.312
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.2981 0.2958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.006 0.006
Onchocerca volvulus 0.0037 0.0153 0.0588
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0484 0.0872
Brugia malayi hypothetical protein 0.0092 0.0481 0.0453
Brugia malayi CHE-14 protein 0.0045 0.0199 0.0169
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.006 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.1094 0.6505 0.6505
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0161
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0322 0.0546
Loa Loa (eye worm) hypothetical protein 0.0283 0.1629 0.1629
Echinococcus multilocularis para nitrobenzyl esterase 0.0283 0.1629 0.1601
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.006 0.006
Brugia malayi hypothetical protein 0.0081 0.0415 0.0387
Entamoeba histolytica hypothetical protein 0.0081 0.0415 0.312
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1444 0.2733
Onchocerca volvulus 0.0039 0.0161 0.0644
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0484 0.0779
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.026 0.026
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0322 0.0289
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0073 0.0073
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0221 0.1256 1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0161 0.0234
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0309 0.1783 0.1783
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0041 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0161 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0004
Mycobacterium tuberculosis Conserved protein 0.0039 0.0161 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0054 0.025 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0161 0.021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.006 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.006 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0161
Onchocerca volvulus Huntingtin homolog 0.0263 0.1512 0.925
Echinococcus multilocularis solute carrier family 5 0.0037 0.0153 0.0119
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0484 0.0872
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0054 0.025 0.0217
Schistosoma mansoni tyrosine kinase 0.0202 0.1144 0.1144
Echinococcus granulosus acetylcholinesterase 0.1675 1 1
Onchocerca volvulus 0.0077 0.0392 0.2114
Loa Loa (eye worm) hypothetical protein 0.0263 0.1512 0.1512
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0037 0.0003
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0153 0.0119
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0153 0.0119
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.006 0.006
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0876 0.5194 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.006 0.0027
Brugia malayi hypothetical protein 0.0263 0.1512 0.1486
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0161 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0023
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0876 0.5194 1
Echinococcus multilocularis acetylcholinesterase 0.1675 1 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1675 1 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0041 0.0041
Echinococcus multilocularis BC026374 protein (S09 family) 0.0283 0.1629 0.1601
Schistosoma mansoni coup transcription factor 0.0022 0.006 0.006
Brugia malayi hypothetical protein 0.0508 0.2981 0.296
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0221 0.1256 0.1227
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0073 0.004
Brugia malayi Bromodomain containing protein 0.0048 0.0218 0.0189
Mycobacterium tuberculosis Conserved protein 0.0039 0.0161 0.0234
Loa Loa (eye worm) TK/ABL protein kinase 0.0205 0.1161 0.1161
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0484 0.0872
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0072 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0077
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0221 0.1256 0.1227
Loa Loa (eye worm) hypothetical protein 0.1675 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0034 0.0012
Brugia malayi beta-lactamase family protein 0.0039 0.0161 0.0132
Echinococcus multilocularis carboxylesterase 5A 0.1675 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Brugia malayi beta-lactamase family protein 0.0039 0.0161 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0923 0.1722
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.006 0.0031
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.025
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.006 0.006
Echinococcus multilocularis high affinity choline transporter 1 0.0339 0.1969 0.1942
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0086 0.0101
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0221 0.1256 0.5
Onchocerca volvulus 0.0283 0.1629 1
Brugia malayi Carboxylesterase family protein 0.0283 0.1629 0.1604
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0976 0.1826
Echinococcus granulosus FTZ F1 alpha 0.0022 0.006 0.0027
Loa Loa (eye worm) hypothetical protein 0.1675 1 1
Schistosoma mansoni inositol transporter 0.0037 0.0153 0.0153
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0876 0.5194 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.006 0.0027
Echinococcus multilocularis Polycystic kidney disease protein 0.0077 0.0392 0.036
Entamoeba histolytica hypothetical protein 0.0081 0.0415 0.312
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.006 0.0027
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0767 0.1171
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0041 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0034 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.006 0.0027
Echinococcus multilocularis dna polymerase eta 0.0019 0.0041 0.0007
Schistosoma mansoni rab6-interacting 0.0077 0.0392 0.0392
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0161 0.0234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0169 0.0946 0.0919
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.006 0.0027
Leishmania major DNA polymerase eta, putative 0.0019 0.0041 0.0023
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0462 0.2706 0.2682
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0037 0.0003
Toxoplasma gondii hypothetical protein 0.0048 0.0214 0.0349
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0484 0.0872
Schistosoma mansoni hypothetical protein 0.0054 0.025 0.025
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0283 0.1629 0.3083
Schistosoma mansoni thyroid hormone receptor 0.0022 0.006 0.006
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0086 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0054 0.025 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1444 0.2733
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0424 0.0756
Loa Loa (eye worm) hypothetical protein 0.0045 0.0199 0.0199
Schistosoma mansoni trans-prenyltransferase 0.0221 0.1256 0.1256
Schistosoma mansoni hypothetical protein 0.0116 0.0624 0.0624
Onchocerca volvulus 0.0039 0.0161 0.0644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.026 0.0227
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0041 0.0058
Treponema pallidum octaprenyl-diphosphate synthase 0.0221 0.1256 0.5
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1444 0.1444
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0221 0.1256 0.2359
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0034 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.1436 0.8565 0.8565
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.006 0.006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0012
Schistosoma mansoni inositol transporter 0.0037 0.0153 0.0153
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.006 0.0027
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1701 0.2586
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.006 0.0027
Loa Loa (eye worm) doublecortin family protein 0.0077 0.0392 0.0392
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.006 0.0031
Loa Loa (eye worm) acetyltransferase 0.0309 0.1783 0.1783
Brugia malayi Muscleblind-like protein 0.018 0.1012 0.0986
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0153 0.0119
Brugia malayi hypothetical protein 0.0077 0.0392 0.0363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.006
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0041 0.0023
Brugia malayi Carboxylesterase family protein 0.0283 0.1629 0.1604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.006 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.006 0.0027

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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