Detailed information for compound 1345272

Basic information

Technical information
  • TDR Targets ID: 1345272
  • Name: 5-(1H-indol-2-ylmethylidene)-2-sulfanylidene- 1,3-diazinane-4,6-dione
  • MW: 271.294 | Formula: C13H9N3O2S
  • H donors: 3 H acceptors: 2 LogP: 1.72 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)C(=Cc2cc3c([nH]2)cccc3)C(=O)N1
  • InChi: 1S/C13H9N3O2S/c17-11-9(12(18)16-13(19)15-11)6-8-5-7-3-1-2-4-10(7)14-8/h1-6,14H,(H2,15,16,17,18,19)
  • InChiKey: JZALJKMCUUXBKR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-(1H-indol-2-ylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione
  • 5-(1H-indol-2-ylmethylene)-2-thioxohexahydropyrimidine-4,6-dione
  • 5-(1H-indol-2-ylmethylene)-2-thioxo-hexahydropyrimidine-4,6-quinone
  • 5-(1H-indol-2-ylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
  • MLS001008604
  • SMR000495894
  • ZINC01225660

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens sirtuin 1 Starlite/ChEMBL References
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum M18 aspartyl aminopeptidase Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus aspartyl aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128020 All targets in OG5_128020
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum M18 aspartyl aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Babesia bovis aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax M18 aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase Get druggable targets OG5_129944 All targets in OG5_129944
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_129944 All targets in OG5_129944
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC Get druggable targets OG5_128020 All targets in OG5_128020
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 Get druggable targets OG5_128020 All targets in OG5_128020
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) aspartyl aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128020 All targets in OG5_128020
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Echinococcus multilocularis aspartyl aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to vacuolar aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Probable aminopeptidase PepC Get druggable targets OG5_128020 All targets in OG5_128020
Schistosoma mansoni aspartyl aminopeptidase (M18 family) Get druggable targets OG5_128020 All targets in OG5_128020
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128020 All targets in OG5_128020
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K01463 sirtuin 1 (silent mating type information regulation 2, homolog) 1 [EC:3.5.1.-], putative Get druggable targets OG5_129944 All targets in OG5_129944
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 Get druggable targets OG5_128020 All targets in OG5_128020
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_129944 All targets in OG5_129944
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01267 aspartyl aminopeptidase [EC3.4.11.21], putative Get druggable targets OG5_128020 All targets in OG5_128020
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129944 All targets in OG5_129944
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Aspartyl aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi M18 aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 Get druggable targets OG5_128020 All targets in OG5_128020
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni aspartyl aminopeptidase (M18 family) Get druggable targets OG5_128020 All targets in OG5_128020
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129944 All targets in OG5_129944
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei M18 aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Trypanosoma congolense aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase Get druggable targets OG5_129944 All targets in OG5_129944
Candida albicans similar to vacuolar aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia NAD-dependent histone deacetylase Sir2 Get druggable targets OG5_129944 All targets in OG5_129944
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 Get druggable targets OG5_129944 All targets in OG5_129944
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 Get druggable targets OG5_129944 All targets in OG5_129944
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 Get druggable targets OG5_128020 All targets in OG5_128020
Brugia malayi NAD-dependent deacetylase SIRT1 Get druggable targets OG5_129944 All targets in OG5_129944
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei aspartyl aminopeptidase, putative Get druggable targets OG5_128020 All targets in OG5_128020
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_128020 All targets in OG5_128020
Cryptosporidium parvum possible aspartyl aminopeptidase Get druggable targets OG5_128020 All targets in OG5_128020
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 Get druggable targets OG5_128020 All targets in OG5_128020
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 Get druggable targets OG5_128020 All targets in OG5_128020
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0605 0.1117
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1089 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Trypanosoma brucei SIR2-like protein 4, putative 0.002 0.0644 0.1189
Onchocerca volvulus 0.0179 0.8685 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0257 0.0223
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.002 0.0644 0.1189
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0064 0.0085
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.1174 0.1174
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.1174 0.1174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.0151 0.7282 0.8372
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0136 0.0136
Brugia malayi ecdysteroid receptor 0.0012 0.0257 0.0223
Schistosoma mansoni smad1 5 8 and 0.001 0.0136 0.0136
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0087 0.4029 0.7441
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0605 0.0861
Echinococcus multilocularis serotonin transporter 0.0179 0.8685 0.8685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0257 0.0223
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0641 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2436 0.2436
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.4642
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0605 0.1117
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0064 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.1089 0.1555
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.2028 0.5033
Brugia malayi nuclear receptor NHR-88 0.0012 0.0257 0.0223
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0603 0.0625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0257 0.0257
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.1174 0.1174
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.0644 0.0672
Loa Loa (eye worm) glutathione reductase 0.0057 0.253 0.286
Loa Loa (eye worm) hypothetical protein 0.0029 0.1089 0.1188
Schistosoma mansoni coup transcription factor 0.0012 0.0257 0.0257
Schistosoma mansoni chromatin regulatory protein sir2 0.0151 0.7282 0.7282
Brugia malayi nuclear hormone receptor 0.0012 0.0257 0.0223
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.1288
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0257 0.0257
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0136 0.0083
Plasmodium vivax NAD-dependent deacetylase, putative 0.002 0.0644 0.1597
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.1174 0.1174
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0257 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0257 0.0223
Mycobacterium ulcerans Sir2-like regulatory protein 0.002 0.0644 0.5913
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0375 0.036
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0136 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0257 0.0223
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.1174 0.1174
Brugia malayi Thioredoxin reductase 0.0057 0.253 0.286
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Plasmodium vivax amine transporter, putative 0.003 0.1174 0.2915
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.5415 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0641 0.0641
Loa Loa (eye worm) aspartyl aminopeptidase 0.0087 0.4029 0.4599
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0064 0.0592
Echinococcus multilocularis aspartyl aminopeptidase 0.0087 0.4029 0.4029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.6234 0.8934
Leishmania major silent information regulator 2, putative 0.002 0.0644 0.1189
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0641 0.2533
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0644 0.0644
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.2245 0.8873
Brugia malayi steroid hormone receptor 0.0012 0.0257 0.0223
Mycobacterium ulcerans hypothetical protein 0.0029 0.1089 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0257 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0257 0.0223
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0641 0.5887
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0064 0.0592
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.2245 0.5572
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.0644 0.0672
Plasmodium falciparum thioredoxin reductase 0.002 0.0641 0.159
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0644 0.0644
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.5415 0.6206
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0087 0.4029 0.5777
Onchocerca volvulus 0.003 0.1174 0.1288
Toxoplasma gondii hypothetical protein 0.003 0.1174 0.4642
Schistosoma mansoni Smad4 0.001 0.0136 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0064 0.0119
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0605 0.0605
Treponema pallidum sodium- and chloride- dependent transporter 0.0179 0.8685 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.697 1
Giardia lamblia Transcriptional regulator, Sir2 family 0.002 0.0644 0.0004
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.2245 0.3021
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0257 0.0257
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0605 0.1117
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0087 0.4029 0.4029
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0087 0.4029 0.5493
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.6939 0.7974
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0087 0.4029 0.5741
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.253 0.628
Mycobacterium tuberculosis Transcriptional regulatory protein 0.002 0.0644 0.0916
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.002 0.0644 0.1189
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2436 0.2751
Loa Loa (eye worm) hypothetical protein 0.0087 0.4029 0.4599
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.2028 0.2089
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0151 0.7282 0.7282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2436 0.2436
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0644 0.0644
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0641 0.5887
Schistosoma mansoni hypothetical protein 0.0041 0.1723 0.1723
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0257 0.0223
Trypanosoma brucei Silent information regulator 2 related protein 1 0.002 0.0644 0.1189
Schistosoma mansoni hypothetical protein 0.0019 0.0603 0.0603
Echinococcus granulosus smad 0.001 0.0136 0.0136
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0644 0.1189
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0087 0.4029 0.7441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0257 0.0223
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.1174 0.1174
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0257 0.0257
Plasmodium falciparum glutathione reductase 0.0057 0.253 0.628
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.1089 0.201
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0603 0.0603
Plasmodium falciparum transcriptional regulatory protein sir2b 0.002 0.0644 0.1597
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.1174 0.1174
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.1089 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0064 0.0064
Plasmodium falciparum amino acid transporter, putative 0.003 0.1174 0.2915
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.1174 0.1174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0663 0.0944
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.4642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0663 0.0944
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0257 0.0257
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0641 0.1183
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.0644 0.0672
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0151 0.7282 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0641 0.0641
Echinococcus granulosus aspartyl aminopeptidase 0.0087 0.4029 0.4029
Giardia lamblia Hypothetical protein 0.002 0.0644 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0151 0.7282 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.1174 0.1174
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.1288
Loa Loa (eye worm) Smad1 0.001 0.0136 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0257 0.0223
Echinococcus granulosus Smad4 0.001 0.0136 0.0136
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0087 0.4029 0.7441
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0087 0.4029 1
Loa Loa (eye worm) norepinephrine transporter 0.0179 0.8685 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.1174 0.1174
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0064 0.0085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.1089 0.1555
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.002 0.0644 0.0644
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0641 0.0798
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.1174 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0722 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1089 0.1188
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0257 0.0257
Brugia malayi Aspartyl aminopeptidase 0.0087 0.4029 0.4599
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0605 0.0605
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.002 0.0644 0.1189
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1089 0.1188
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.1174 0.1174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0257 0.0257
Schistosoma mansoni smad 0.001 0.0136 0.0136
Onchocerca volvulus 0.003 0.1174 0.1288
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0064 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.006 0.2687 0.3042
Onchocerca volvulus 0.003 0.1174 0.1288
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0641 0.1183
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0257 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Loa Loa (eye worm) sirtuin 4 0.002 0.0644 0.0672
Trypanosoma brucei Silent information regulator 2 related protein 3 0.002 0.0644 0.1189
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.6234 0.8943
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0064 0.0255
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0151 0.7282 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.1174 0.1174
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0064 0.0119
Schistosoma mansoni smad1 5 8 and 0.001 0.0136 0.0136
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0064 0.0592
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0257 0.0257
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0257 0.0257
Brugia malayi MH1 domain containing protein 0.001 0.0136 0.0083
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.697 1
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0064 0.0119
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0641 0.2533
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0257 0.0223
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.5415 0.5415
Brugia malayi MH1 domain containing protein 0.001 0.0136 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2436 0.2436
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0605 0.0605
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0375 0.036
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.1697 0.2261
Echinococcus granulosus serotonin transporter 0.0179 0.8685 0.8685
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0605 0.2391
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0605 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.1697 0.2261
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0722 0.0763
Loa Loa (eye worm) serotonin transporter b 0.0179 0.8685 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0136 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0257 0.0223
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0064 0.0592
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0605 0.0605
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0257 0.0257
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0641 0.5887
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0722 0.1029
Loa Loa (eye worm) hypothetical protein 0.0179 0.8685 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0605 0.0627
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0257 0.0223
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0641 0.1183
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.1174 0.1174
Brugia malayi hypothetical protein 0.003 0.1174 0.1288
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0605 0.1501
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Echinococcus granulosus GPCR family 2 0.0019 0.0603 0.0603
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0641 0.1183
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0131 0.6277 0.7207
Brugia malayi Smad1 0.001 0.0136 0.0083
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.002 0.0644 0.0644
Toxoplasma gondii histone deacetylase SIR2 0.002 0.0644 0.2544
Toxoplasma gondii thioredoxin reductase 0.0057 0.253 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.8501 0.9787
Loa Loa (eye worm) transcriptional regulator 0.002 0.0644 0.0672
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0257 0.0257
Brugia malayi isocitrate dehydrogenase 0.0019 0.0605 0.0627
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0064 0.0592
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.5415 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0064 0.0592
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1089 0.201
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.1174 0.1174
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.1174 0.1174
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0151 0.7282 0.7282
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0136 0.0136
Entamoeba histolytica aminopeptidase, putative 0.0087 0.4029 0.7441
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2498 0.3372
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0644 0.0644
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2436 0.2751
Brugia malayi NAD-dependent deacetylase SIRT1 0.0151 0.7282 0.8372
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.1089 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.5415 0.5415
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0257 0.0257
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0644 0.0644
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.6939 0.7974
Loa Loa (eye worm) transcriptional regulator 0.002 0.0644 0.0672
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0257 0.0257
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0641 0.0912
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.002 0.0644 0.0644
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0605 0.2391
Schistosoma mansoni hypothetical protein 0.0019 0.0603 0.0603
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.697 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1089 1
Echinococcus multilocularis geminin 0.0205 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0641 0.159
Echinococcus multilocularis chromatin regulatory protein sir2 0.002 0.0644 0.0644
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.5415 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0257 0.0257
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.253 0.3625
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0257 0.0223
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0064 0.0119
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0064 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0603 0.0625
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0722 0.1792
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.1089 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.002 0.0644 0.5913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0722 0.0763
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.002 0.0644 0.0644
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2687 0.3042
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0064 0.0119
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0257 0.0223
Onchocerca volvulus 0.0012 0.0257 0.0223
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.1089 1
Brugia malayi glutathione reductase 0.0057 0.253 0.286
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0257 0.0257
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0064 0.0119
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.5415 0.5415
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0257 0.0257
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0605 0.0605
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0064 0.016
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0257 0.0223
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0064 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2687 0.3042
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2436 0.2436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2687 0.3042
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.2028 0.3745
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0722 0.6633
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0064 0.0085
Giardia lamblia Kinase, PLK 0.0114 0.5415 0.7189
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.697 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0179 0.8685 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0257 0.0223
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0605 0.1501
Echinococcus multilocularis GPCR, family 2 0.0019 0.0603 0.0603
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0257 0.0257
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.6234 0.8943
Loa Loa (eye worm) solute carrier family 6 member 4 0.0179 0.8685 1
Schistosoma mansoni hypothetical protein 0.0019 0.0603 0.0603
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0605 0.1117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0257 0.0223
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.0644 0.1189
Schistosoma mansoni kinase 0.0058 0.2574 0.2574
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Plasmodium falciparum transcriptional regulatory protein sir2a 0.002 0.0644 0.1597
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0663 0.0944
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0722 0.1792
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.1288
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0603 0.0625
Loa Loa (eye worm) hypothetical protein 0.0179 0.8685 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.002 0.0644 0.1189
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.002 0.0644 0.1189
Plasmodium vivax hypothetical protein, conserved 0.002 0.0644 0.1597
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0087 0.4029 0.7441
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0641 0.159
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0087 0.4029 0.5493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.1089 0.201
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0064 0.0085
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.1089 0.1483
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.5415 1
Schistosoma mansoni hypothetical protein 0.0205 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1723 0.1923
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.2245 0.3021
Echinococcus multilocularis Smad4 0.001 0.0136 0.0136
Plasmodium vivax glutathione reductase, putative 0.0057 0.253 0.628
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.1174 0.1174
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0605 0.0605
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0641 0.159
Trypanosoma brucei polo-like protein kinase 0.0114 0.5415 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0064 0.0592
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0603 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0257 0.0223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2436 0.2436
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2498 0.3372
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.8501 0.8501
Giardia lamblia Sirtuin type 2 0.002 0.0644 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1089 0.201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0064 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.5415 0.6206
Schistosoma mansoni sodium/chloride dependent transporter 0.0179 0.8685 0.8685
Brugia malayi MH2 domain containing protein 0.001 0.0136 0.0083
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0064 0.0119
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0641 0.0668
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.1193 0.1193
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.253 0.4673
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Mycobacterium tuberculosis Probable reductase 0.013 0.6234 0.8943
Leishmania major sir2-family protein-like protein 0.002 0.0644 0.1189
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0087 0.4029 0.5493
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0064 0.0064
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.1174 0.1174
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0087 0.4029 0.7441
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.6234 0.8943
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.8253 0.8253
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.1174 0.1174
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0257 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.5415 0.6206
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1089 1
Echinococcus multilocularis smad 0.001 0.0136 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.1089 0.1483
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0641 0.1183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0603 0.0603
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.0644 0.1189
Onchocerca volvulus 0.0029 0.1089 0.1188
Trypanosoma brucei trypanothione reductase 0.0057 0.253 0.4673
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0641 0.1183
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0257 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Toxoplasma gondii hypothetical protein 0.003 0.1174 0.4642
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.1174 0.1174
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0641 0.0641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0257 0.0223
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0064 0.0119
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0064 0.0592
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0064 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2436 0.2436
Plasmodium falciparum transporter, putative 0.003 0.1174 0.2915
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.0644 0.1189
Brugia malayi Cytochrome P450 family protein 0.0022 0.0767 0.0815
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0641 0.159
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.6234 0.8943
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.4642
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0064 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0663 0.0944
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0605 0.1117
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.1174 0.1288
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.2245 0.8873
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.1288
Loa Loa (eye worm) hypothetical protein 0.0012 0.0257 0.0223
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0605 0.0605
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.8501 0.8501
Leishmania major trypanothione reductase 0.0057 0.253 0.4673
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0064 0.0085
Brugia malayi MH2 domain containing protein 0.0144 0.6939 0.7974
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0041 0.1697 0.2261
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0257 0.0257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0257 0.0257
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0257 0.0257
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.253 0.253
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.8501 0.9787
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0179 0.8685 0.8685
Loa Loa (eye worm) hypothetical protein 0.0087 0.4029 0.4599
Loa Loa (eye worm) hypothetical protein 0.0029 0.1089 0.1188
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0136 0.0136
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0064 0.0085
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0136 0.0136
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.1174 0.1288
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.253 0.286
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0257 0.0257
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.1174 0.1174
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0087 0.4029 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0257 0.0257
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.253 0.253
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0064 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1723 0.1923
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.0644 0.0802
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0151 0.7282 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2436 0.2436
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.002 0.0644 0.0644
Plasmodium falciparum glutathione reductase 0.002 0.0641 0.159
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.1089 0.201
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0641 0.1183
Loa Loa (eye worm) transcriptional regulator 0.002 0.0644 0.0672
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.003 0.1174 0.1288
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0064 0.0592
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0257 0.0257
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0041 0.1697 0.2261
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0641 0.1183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0641 0.1183
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0087 0.4029 0.4029
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0064 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0257 0.0257
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.2245 0.2245
Loa Loa (eye worm) hypothetical protein 0.0029 0.1089 0.1188
Plasmodium vivax hypothetical protein, conserved 0.003 0.1174 0.2915
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0257 0.0223
Trichomonas vaginalis hypothetical protein 0.0041 0.1697 0.2261
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0257 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0722 0.0763
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.1174 0.1174
Schistosoma mansoni hypothetical protein 0.0205 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0767 0.0815
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0257 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5415 0.7413
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0257 0.0223
Brugia malayi MH2 domain containing protein 0.001 0.0136 0.0083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0641 0.1183
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.002 0.0644 0.1189
Loa Loa (eye worm) hypothetical protein 0.0179 0.8685 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.6234 0.8943
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0722 0.1523
Loa Loa (eye worm) hypothetical protein 0.0019 0.0603 0.0625
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0087 0.4029 0.7441
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.1697 0.2261
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0151 0.7282 1
Toxoplasma gondii histone deacetylase SIR2-like 0.002 0.0644 0.2544
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.002 0.0644 0.0644
Loa Loa (eye worm) hypothetical protein 0.0021 0.0722 0.0763
Schistosoma mansoni hypothetical protein 0.0019 0.0603 0.0603
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0064 0.0085
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0064 0.0255
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0041 0.1697 0.2261
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0064 0.0592
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1089 0.1188
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0644 0.0644
Plasmodium falciparum thioredoxin reductase 0.0057 0.253 0.628
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0641 0.0798
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1089 0.201
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0641 0.5
Echinococcus granulosus chromatin regulatory protein sir2 0.002 0.0644 0.0644

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 6 uM PUBCHEM_BIOASSAY: Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr1 with Hit compounds from Cherry Pick1. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 1.671 um PUBCHEM_BIOASSAY: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). (Class of assay: confirmatory) [Related PubChem assays: 2170 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)] ChEMBL. No reference
IC50 (binding) = 5.9 uM Inhibition of recombinant human GST-tagged SIRT-1 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assay ChEMBL. No reference
IC50 (binding) = 6 uM Inhibition of SIRT1 ChEMBL. 21080630
IC50 (binding) = 20 uM Inhibition of SIRT2 ChEMBL. 21080630
IC50 (binding) > 59.642 um PUBCHEM_BIOASSAY: QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). (Class of assay: confirmatory) [Related pubchem assays: 2178 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)] ChEMBL. No reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 0.5174 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.3371 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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