Detailed information for compound 1359203

Basic information

Technical information
  • TDR Targets ID: 1359203
  • Name: propan-2-yl 5-chloro-1-[(2,4-dichlorophenyl)m ethyl]-6-oxopyridine-3-carboxylate
  • MW: 374.646 | Formula: C16H14Cl3NO3
  • H donors: 0 H acceptors: 2 LogP: 4.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)c1cn(Cc2ccc(cc2Cl)Cl)c(=O)c(c1)Cl)C
  • InChi: 1S/C16H14Cl3NO3/c1-9(2)23-16(22)11-5-14(19)15(21)20(8-11)7-10-3-4-12(17)6-13(10)18/h3-6,8-9H,7H2,1-2H3
  • InChiKey: VVZWXZWTXUVJDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl 5-chloro-1-[(2,4-dichlorophenyl)methyl]-6-oxo-pyridine-3-carboxylate
  • 5-chloro-1-[(2,4-dichlorophenyl)methyl]-6-oxo-3-pyridinecarboxylic acid isopropyl ester
  • 5-chloro-1-(2,4-dichlorobenzyl)-6-keto-nicotinic acid isopropyl ester
  • propan-2-yl 5-chloro-1-[(2,4-dichlorophenyl)methyl]-6-oxo-pyridine-3-carboxylate
  • Oprea1_786683
  • 10E-367S
  • ZINC03041712
  • Bionet1_000449

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0852 0.159
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0035 0.0065
Schistosoma mansoni smad1 5 8 and 0.0017 0.0035 0.0065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.004 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.1238 0.2312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0203 0.0379
Loa Loa (eye worm) hypothetical protein 0.0153 0.0852 0.159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.023 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Echinococcus multilocularis endoplasmin 0.0031 0.012 0.012
Brugia malayi hypothetical protein 0.0012 0.001 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0156 0.0373
Trypanosoma cruzi cysteine proteinase, putative 0.0386 0.2243 0.4178
Trypanosoma cruzi cysteine peptidase, putative 0.0666 0.3918 0.731
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0218 0.0406
Trichomonas vaginalis heat shock protein, putative 0.0031 0.012 0.0178
Trypanosoma brucei trypanothione reductase 0.0047 0.0218 0.0533
Brugia malayi nuclear hormone receptor 0.0033 0.0133 0.0249
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0033 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0666 0.3918 0.7099
Echinococcus granulosus lysine specific demethylase 5A 0.0252 0.1442 0.2693
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Brugia malayi Endoplasmin precursor 0.0039 0.0167 0.0311
Giardia lamblia Cathepsin B precursor 0.0153 0.0852 0.1494
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0334 0.0624
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0029 0.0054
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.012 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0433 0.2526 0.4563
Plasmodium falciparum endoplasmin, putative 0.0024 0.0078 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0233 0.1327 0.2465
Schistosoma mansoni nuclear receptor 0.0016 0.0029 0.0054
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0907 0.5356 1
Echinococcus granulosus cathepsin l1 0.0666 0.3918 0.7314
Trichomonas vaginalis rotamase, putative 0.004 0.0177 0.0282
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.012 0.0207
Onchocerca volvulus 0.0012 0.001 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1371 0.2559
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0022 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0133 0.0249
Echinococcus multilocularis musashi 0.0027 0.0095 0.0095
Schistosoma mansoni smad 0.0017 0.0035 0.0065
Onchocerca volvulus 0.0033 0.0133 0.034
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0579 0.2146
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0334 0.0624
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Brugia malayi Myosin head containing protein 0.0012 0.001 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0049 0.0091
Echinococcus granulosus cathepsin l cysteine peptidase 0.0666 0.3918 0.7314
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0666 0.3918 0.7099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0252 0.1442 0.2693
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0348 0.0348
Plasmodium falciparum serine repeat antigen 5 0.0153 0.0852 0.2154
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.023 0.0788
Onchocerca volvulus 0.0014 0.0022 0.0057
Brugia malayi hypothetical protein 0.0017 0.004 0.0075
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0065 0.0142
Plasmodium falciparum glutathione reductase 0.0047 0.0218 0.0531
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2888 0.2888
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0826 0.1543
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0907 0.5356 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0095 0.0177
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0033 0.2199
Schistosoma mansoni phosphatidylserine receptor 0.0067 0.0334 0.0624
Loa Loa (eye worm) patched family protein 0.0012 0.001 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0074
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0167 0.0295
Toxoplasma gondii cathepsin CPC1 0.0153 0.0852 0.2174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0045
Brugia malayi Importin beta-1 subunit 0.0029 0.0111 0.0207
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0455 0.2659 1
Onchocerca volvulus 0.0012 0.001 0.0025
Plasmodium vivax unspecified product 0.0386 0.2243 0.5715
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0078 0.0101
Brugia malayi cathepsin Z-like cysteine proteinase 0.0153 0.0852 0.159
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0329 0.0839
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0157 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0291
Schistosoma mansoni rotamase 0.004 0.0177 0.033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0203 0.0379
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0069 0.0346 0.0646
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0579 0.2146
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0033 0.0063
Echinococcus multilocularis jumonji domain containing 1A 0.0067 0.0334 0.0334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0386 0.2243 0.5716
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Plasmodium falciparum cysteine proteinase falcipain 1 0.0386 0.2243 0.5715
Loa Loa (eye worm) patched family protein 0.0012 0.001 0.0019
Schistosoma mansoni zinc finger protein 0.0016 0.0029 0.0054
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0133 0.0249
Onchocerca volvulus 0.0016 0.0029 0.0074
Echinococcus granulosus cathepsin L cysteine proteinase 0.0666 0.3918 0.7314
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0133 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0177 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0029 0.0029
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0111 0.0283
Brugia malayi Patched related family protein 12 0.0012 0.001 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.0666 0.3918 0.7099
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.1238 0.2312
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0852 0.1512
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0167 0.0295
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0153 0.0852 0.2154
Onchocerca volvulus Cathepsin L homolog 0.0666 0.3918 1
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0348 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0033 0.0062
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0167 0.0426
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0133 0.0249
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.023 0.041
Echinococcus multilocularis JmjC domain containing protein 4 0.0067 0.0334 0.0334
Brugia malayi Cathepsin L-like precursor 0.0666 0.3918 0.7314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0042
Echinococcus multilocularis cysteine protease 0.0666 0.3918 0.3918
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0218 0.0531
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.023 0.041
Trypanosoma brucei heat shock protein 84, putative 0.0016 0.003 0.0055
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0022 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0334 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0852 0.1512
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0133 0.0133
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0852 0.1512
Brugia malayi Cytochrome P450 family protein 0.0028 0.0102 0.019
Giardia lamblia Fructose-bisphosphate aldolase 0.0932 0.5509 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0144 0.0504
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0039
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0157 0.0293
Echinococcus granulosus lamin 0.0027 0.0095 0.0177
Entamoeba histolytica cysteine protease, putative 0.0153 0.0852 0.1512
Plasmodium vivax glutathione reductase, putative 0.0047 0.0218 0.0531
Echinococcus granulosus importin subunit beta 1 0.0029 0.0111 0.0207
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.065 0.2382
Schistosoma mansoni smad1 5 8 and 0.0017 0.0035 0.0065
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0045
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0033 0.0062
Loa Loa (eye worm) oxidoreductase 0.0014 0.0022 0.0042
Echinococcus granulosus cpg binding protein 0.0037 0.0155 0.0289
Entamoeba histolytica Ran family GTPase 0.0022 0.0065 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0852 0.159
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0133 0.0249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0133 0.0249
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0171 0.0415
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0049 0.0052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0852 0.159
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0321 0.1174
Brugia malayi cathepsin L-like cysteine proteinase 0.0153 0.0852 0.159
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0348 0.065
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0229 0.0427
Schistosoma mansoni hypothetical protein 0.0069 0.0348 0.065
Plasmodium vivax importin-beta 2, putative 0.0029 0.0111 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0852 0.1512
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0022
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.003 0.0057
Echinococcus multilocularis cathepsin L cysteine protease 0.0666 0.3918 0.3918
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0111 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0028 0.0072
Toxoplasma gondii cathepsin CPC2 0.0153 0.0852 0.2174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0133 0.0249
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0102 0.019
Giardia lamblia Cathepsin B precursor 0.0386 0.2245 0.4038
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0236 0.0441
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0022 0.0031
Trypanosoma cruzi cysteine proteinase, putative 0.0386 0.2243 0.4178
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0033 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0018
Schistosoma mansoni glutaminase 0.0862 0.5088 0.9499
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0028 0.0028
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Plasmodium vivax endoplasmin, putative 0.0039 0.0167 0.0401
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0022 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0153 0.0852 0.1512
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0067 0.0334 0.0832
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0153 0.0852 0.2154
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0852 0.1512
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0386 0.2243 0.4178
Loa Loa (eye worm) hypothetical protein 0.0077 0.0396 0.0739
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0167 0.0295
Echinococcus granulosus expressed protein 0.004 0.0177 0.033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Loa Loa (eye worm) patched family protein 0.0012 0.001 0.0019
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0133 0.0249
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Onchocerca volvulus 0.0666 0.3918 1
Brugia malayi fibroinase precursor 0.0153 0.0852 0.159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0133 0.0249
Schistosoma mansoni protein phosphatase 2C 0.0067 0.0334 0.0624
Echinococcus granulosus cathepsin b 0.0907 0.5356 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0133 0.0249
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.1804 0.3368
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0156 1
Brugia malayi nuclear hormone receptor 0.0016 0.0029 0.0054
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0065 0.0121
Trypanosoma cruzi heat shock protein, putative 0.0016 0.003 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Echinococcus granulosus cathepsin L cysteine protease 0.0386 0.2243 0.4188
Loa Loa (eye worm) hypothetical protein 0.0069 0.0348 0.065
Brugia malayi protein C24B5.3 0.0012 0.001 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0011 0.00000027528 0.00000051397
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0095 0.0177
Echinococcus granulosus cathepsin L 0.0153 0.0852 0.159
Brugia malayi Cathepsin L-like precursor 0.0666 0.3918 0.7314
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0133 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0144 0.0504
Entamoeba histolytica cysteine protease, putative 0.0153 0.0852 0.1512
Echinococcus multilocularis dna polymerase eta 0.0019 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0153 0.0852 0.1512
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0455 0.2659 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.004 0.0075
Echinococcus granulosus tumor protein p63 0.0343 0.1986 0.3708
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0029 0.0074
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0049 0.0091
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0033 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0133 0.0249
Echinococcus multilocularis protein dispatched 1 0.01 0.0534 0.0534
Echinococcus multilocularis tumor protein p63 0.0343 0.1986 0.1986
Onchocerca volvulus Cathepsin F homolog 0.0666 0.3918 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0033 0.2199
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0579 0.2146
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0042
Echinococcus multilocularis microtubule associated protein 2 0.082 0.4839 0.4839
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0133 0.0249
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0033 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0033 0.006
Schistosoma mansoni heat shock protein 0.0016 0.003 0.0057
Echinococcus granulosus GPCR family 2 0.0069 0.0348 0.065
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0133 0.0249
Trypanosoma cruzi cysteine peptidase, putative 0.0666 0.3918 0.731
Echinococcus granulosus smad 0.0017 0.0035 0.0065
Brugia malayi nuclear receptor NHR-88 0.0016 0.0029 0.0054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0852 0.159
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0028 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0386 0.2243 0.4047
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Onchocerca volvulus 0.0666 0.3918 1
Echinococcus multilocularis lysine specific demethylase 5A 0.025 0.1431 0.1431
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.023 0.043
Plasmodium falciparum serine repeat antigen 8 0.0153 0.0852 0.2154
Onchocerca volvulus 0.0153 0.0852 0.2174
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.0153 0.0852 0.159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0203 0.0203
Schistosoma mansoni lamin 0.0027 0.0095 0.0177
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Brugia malayi nuclear receptor NHR-67 0.0016 0.0029 0.0054
Trichomonas vaginalis heat shock protein, putative 0.0031 0.012 0.0178
Schistosoma mansoni cathepsin S (C01 family) 0.0153 0.0852 0.159
Giardia lamblia Cathepsin B precursor 0.0153 0.0852 0.1494
Brugia malayi nuclear receptor RXR 0.0016 0.0029 0.0054
Brugia malayi Augmenter of liver regeneration 0.0037 0.0157 0.0293
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Giardia lamblia Cathepsin B precursor 0.0386 0.2245 0.4038
Giardia lamblia Cathepsin B precursor 0.0153 0.0852 0.1494
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0133 0.0133
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Schistosoma mansoni cpg binding protein 0.0035 0.0143 0.0267
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0153 0.0852 0.2154
Onchocerca volvulus 0.0666 0.3918 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0049 0.0048
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0157 0.0276
Schistosoma mansoni hypothetical protein 0.0149 0.0826 0.1543
Brugia malayi Cathepsin L-like precursor 0.0666 0.3918 0.7314
Loa Loa (eye worm) hypothetical protein 0.0433 0.2526 0.4717
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Brugia malayi Cathepsin L-like precursor 0.0433 0.2526 0.4717
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0233 0.1327 0.2478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Plasmodium falciparum importin beta, putative 0.0029 0.0111 0.0258
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0386 0.2245 0.572
Giardia lamblia Cathepsin L precursor 0.0153 0.0852 0.1494
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0143 0.0267
Leishmania major hypothetical protein, conserved 0.0037 0.0157 0.0378
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0852 0.1494
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0579 0.2146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.1327 0.2478
Loa Loa (eye worm) hypothetical protein 0.0153 0.0852 0.159
Schistosoma mansoni hypothetical protein 0.0166 0.0926 0.1729
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0045
Onchocerca volvulus 0.0016 0.0029 0.0074
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0157 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0218 0.1239 0.2313
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.046 0.0859
Leishmania major cysteine peptidase A (CPA) 0.0666 0.3918 1
Echinococcus multilocularis cathepsin L 0.0153 0.0852 0.0852
Plasmodium vivax JmjC domain containing protein 0.0067 0.0334 0.083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0133 0.0249
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0075
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0063
Loa Loa (eye worm) ctsf protein 0.0666 0.3918 0.7314
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.004 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Brugia malayi cathepsin L precursor 0.0153 0.0852 0.159
Loa Loa (eye worm) fibroinase 0.0666 0.3918 0.7314
Echinococcus multilocularis GPCR, family 2 0.0069 0.0348 0.0348
Schistosoma mansoni jumonji/arid domain-containing protein 0.0252 0.1442 0.2693
Onchocerca volvulus 0.0012 0.001 0.0025
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Echinococcus granulosus lamin dm0 0.0027 0.0095 0.0177
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0049 0.0145
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0153 0.0852 0.2154
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0907 0.5356 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0153 0.0852 0.1576
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Schistosoma mansoni nuclear receptor 0.0016 0.0029 0.0054
Giardia lamblia Cathepsin L precursor 0.0153 0.0852 0.1494
Echinococcus multilocularis lamin 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0008 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0133 0.0249
Schistosoma mansoni coup transcription factor 0.0033 0.0133 0.0249
Schistosoma mansoni hypothetical protein 0.0202 0.1146 0.2139
Brugia malayi AMP-binding enzyme family protein 0.0049 0.023 0.043
Brugia malayi hypothetical protein 0.0012 0.001 0.0019
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.004 0.0075
Giardia lamblia Cysteine protease 0.0153 0.0852 0.1494
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.023 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0133 0.0249
Trypanosoma brucei cysteine peptidase C (CPC) 0.0386 0.2245 0.572
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.1238 0.2312
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0133 0.0249
Schistosoma mansoni hypothetical protein 0.0069 0.0348 0.065
Entamoeba histolytica cysteine proteinase, putative 0.0386 0.2243 0.4047
Trichomonas vaginalis rotamase, putative 0.0039 0.0171 0.0272
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0033
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0153 0.0852 0.2154
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0932 0.5509 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.023 0.041
Loa Loa (eye worm) patched family protein 0.0012 0.001 0.0019
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0049 0.0091
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0049 0.0052
Plasmodium vivax heat shock protein 90, putative 0.0016 0.003 0.0053
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0852 0.1494
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.023 0.083
Schistosoma mansoni DNA polymerase eta 0.0019 0.0049 0.0091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0029 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2888 0.5393
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0133 0.0249
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0171 0.0437
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0133 0.0249
Echinococcus granulosus cathepsin b 0.0907 0.5356 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0157 0.0293
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.012 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Giardia lamblia Cathepsin B precursor 0.0386 0.2245 0.4038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Schistosoma mansoni jumonji domain containing protein 0.025 0.1431 0.2671
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Mycobacterium ulcerans hypothetical protein 0.0049 0.023 0.041
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0022 0.0042
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0321 0.0819
Onchocerca volvulus 0.0666 0.3918 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0074
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0167 0.0243
Brugia malayi ecdysone receptor 0.0016 0.0029 0.0054
Onchocerca volvulus 0.0049 0.0229 0.0583
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0067 0.0334 0.0608
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0153 0.0852 0.159
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0028 0.0053
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0029 0.0074
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0133 0.0249
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1391 0.2597
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0133 0.0249
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0171 0.0303
Plasmodium falciparum serine repeat antigen 9 0.0153 0.0852 0.2154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0033 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0376 0.0701
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0153 0.0852 0.1512
Giardia lamblia Cathepsin B precursor 0.0153 0.0852 0.1494
Echinococcus multilocularis cpg binding protein 0.0037 0.0155 0.0155
Toxoplasma gondii hypothetical protein 0.0012 0.001 0.0025
Brugia malayi hypothetical protein 0.0012 0.001 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0348 0.065
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Giardia lamblia Encystation-specific protease 0.0153 0.0852 0.1494
Echinococcus granulosus heat shock protein 90 0.0039 0.0167 0.0311
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0065 0.0165
Plasmodium falciparum cysteine proteinase falcipain 3 0.0666 0.3918 1
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0157 0.04
Onchocerca volvulus 0.0014 0.0022 0.0057
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.012 0.0224
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0111 0.026
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0133 0.0249
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.012 0.0283
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0065 0.0104
Onchocerca volvulus Huntingtin homolog 0.0375 0.2179 0.5562
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0396 0.0989
Loa Loa (eye worm) hypothetical protein 0.0204 0.1158 0.2162
Brugia malayi Patched related family protein 4 0.0012 0.001 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0133 0.0249
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0142 0.0265
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0666 0.3918 0.3918
Trichomonas vaginalis ran, putative 0.0022 0.0065 0.0077
Trypanosoma brucei unspecified product 0.0013 0.0014 0.0011
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.046 0.046
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0028 0.0047
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0153 0.0852 0.2154
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0045
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0078 0.0101
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0153 0.0852 0.159
Trypanosoma brucei RNA helicase, putative 0.0202 0.1146 0.2908
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0321 0.0599
Echinococcus granulosus phd:f box containing protein 0.0067 0.0334 0.0624
Entamoeba histolytica hypothetical protein 0.0153 0.0852 0.1512
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0133 0.0133
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1371 0.1371
Entamoeba histolytica cysteine protease, putative 0.0153 0.0852 0.1512
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Entamoeba histolytica cysteine proteinase 1, putative 0.0386 0.2243 0.4047
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.003 0.0053
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0218 0.0218
Schistosoma mansoni importin beta-1 0.0029 0.0111 0.0207
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0133 0.034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0579 0.2146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0203 0.0379
Onchocerca volvulus Cathepsin L homolog 0.0153 0.0852 0.2174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0433 0.2526 0.4563
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0852 0.1512
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Schistosoma mansoni heat shock protein 0.0039 0.0167 0.0311
Brugia malayi Papain family cysteine protease containing protein 0.0666 0.3918 0.7314
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0167 0.0295
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0133 0.0249
Trypanosoma cruzi major cysteine proteinase, putative 0.0153 0.0852 0.1576
Toxoplasma gondii patched family protein 0.0012 0.001 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Brugia malayi Hsp90 protein 0.0016 0.003 0.0057
Giardia lamblia Grp94/Hsp90 0.0031 0.012 0.0158
Brugia malayi MH1 domain containing protein 0.0017 0.0035 0.0065
Schistosoma mansoni cpg binding protein 0.0037 0.0155 0.0289
Giardia lamblia Hypothetical protein 0.0153 0.0852 0.1494
Echinococcus multilocularis cathepsin b 0.0907 0.5356 0.5356
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0029 0.0054
Brugia malayi jmjC domain containing protein 0.025 0.1431 0.2671
Plasmodium falciparum JmjC domain-containing protein, putative 0.0067 0.0334 0.083
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0171 0.0303
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Trichomonas vaginalis glutaminase, putative 0.0862 0.5088 0.9231
Onchocerca volvulus Protein patched homolog 0.0012 0.001 0.0025
Leishmania major DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Brugia malayi nuclear receptor NHR-88 0.0033 0.0133 0.0249
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.003 0.003
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0022 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0078 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0852 0.1512
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0852 0.159
Echinococcus multilocularis expressed protein 0.004 0.0177 0.0177
Schistosoma mansoni cpg binding protein 0.0037 0.0155 0.0289
Echinococcus multilocularis cathepsin L cysteine protease 0.0666 0.3918 0.3918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0133 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0045
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0067 0.0334 0.0624
Plasmodium vivax serine-repeat antigen (SERA) 0.0153 0.0852 0.2154
Schistosoma mansoni lamin 0.0027 0.0095 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0852 0.1512
Loa Loa (eye worm) hypothetical protein 0.0049 0.023 0.043
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0852 0.159
Echinococcus granulosus lysine specific demethylase 6a 0.0067 0.0334 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.0011
Onchocerca volvulus 0.0012 0.001 0.0025
Brugia malayi CXXC zinc finger family protein 0.0035 0.0143 0.0267
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0028 0.0072
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0153 0.0852 0.159
Brugia malayi hypothetical protein 0.0012 0.001 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.023 0.0788
Echinococcus granulosus heat shock protein 0.0039 0.0167 0.0311
Schistosoma mansoni endoplasmin 0.0039 0.0167 0.0311
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0153 0.0852 0.1512
Loa Loa (eye worm) hypothetical protein 0.0218 0.1238 0.2312
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0078 0.0101
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0167 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.046 0.0798
Plasmodium falciparum glutathione reductase 0.0016 0.0033 0.006
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0153 0.0852 0.2154
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0153 0.0852 0.1512
Schistosoma mansoni heat shock protein 0.0039 0.0167 0.0311
Plasmodium falciparum serine repeat antigen 6 0.0153 0.0852 0.2154
Giardia lamblia Hypothetical protein 0.0153 0.0852 0.1494
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0111 0.026
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0022 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0133 0.0249
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0022 0.0057
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0167 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0133 0.0249
Loa Loa (eye worm) patched family protein 0.0012 0.001 0.0019
Entamoeba histolytica cysteine protease, putative 0.0153 0.0852 0.1512
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0386 0.2243 0.4188
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0029 0.0054
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0049 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0386 0.2245 0.405
Brugia malayi Cathepsin L-like cysteine proteinase 0.0433 0.2526 0.4717
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.0011
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0045
Brugia malayi cathepsin Z-like cysteine proteinase 0.0153 0.0852 0.159
Trypanosoma cruzi cruzipain precursor, putative 0.0666 0.3918 0.731
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0177 0.033
Brugia malayi Cathepsin L-like precursor 0.0233 0.1327 0.2478
Leishmania major trypanothione reductase 0.0047 0.0218 0.0533
Echinococcus multilocularis cathepsin b 0.0907 0.5356 0.5356
Brugia malayi Niemann-Pick C1 protein precursor 0.0204 0.1158 0.2162
Onchocerca volvulus 0.0027 0.0095 0.0242
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0029 0.0054
Brugia malayi Patched related family protein 10 0.0012 0.001 0.0019
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0167 0.0263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.0386 0.2243 0.4047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0291
Giardia lamblia Cathepsin L-like protease 0.0153 0.0852 0.1494
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0167 0.0295
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.003 0.0078
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0067 0.0334 0.0854
Brugia malayi jmjC domain containing protein 0.0067 0.0334 0.0624
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0022 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0666 0.3918 0.7314
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0028 0.0053
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.003 0.0078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0852 0.159
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0133 0.0249
Entamoeba histolytica cysteine proteinase, putative 0.0386 0.2243 0.4047
Schistosoma mansoni hypothetical protein 0.0069 0.0348 0.065
Echinococcus multilocularis snurportin 1 0.0312 0.1804 0.1804
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0063
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0072 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0142 0.0142
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0028 0.0049
Echinococcus granulosus cysteine protease 0.0386 0.2243 0.4188
Giardia lamblia Cathepsin L precursor 0.0153 0.0852 0.1494
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Plasmodium vivax vivapain-2 0.0666 0.3918 1
Brugia malayi N-terminal motif family protein 0.0218 0.1239 0.2313
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0153 0.0852 0.159
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.023 0.041
Brugia malayi cathepsin L-like precursor 0.0433 0.2526 0.4717
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0133 0.0249
Schistosoma mansoni intermediate filament proteins 0.0027 0.0095 0.0177
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0156 0.0549
Brugia malayi intermediate filament protein 0.0027 0.0095 0.0177
Brugia malayi Thioredoxin reductase 0.0047 0.0218 0.0406
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0013 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0144 0.0504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0033
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0153 0.0852 0.2154
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0666 0.3918 1
Brugia malayi RNA, U transporter 1 0.0083 0.0433 0.0809
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0218 0.0783
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0348 0.0348
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Trypanosoma cruzi cysteine peptidase, putative 0.0666 0.3918 0.731
Entamoeba histolytica cysteine proteinase 2 0.0386 0.2243 0.4047
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.1682 0.3141
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0075
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0029 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0386 0.2243 0.4188
Brugia malayi Cathepsin L-like precursor 0.0666 0.3918 0.7314
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.023 0.041
Brugia malayi jmjC domain containing protein 0.0252 0.1442 0.2693
Leishmania major heat shock protein, putative 0.0016 0.003 0.0055
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.023 0.043
Brugia malayi hypothetical protein 0.0077 0.0396 0.0739
Onchocerca volvulus 0.0433 0.2526 0.6449
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.065 0.2417
Loa Loa (eye worm) hypothetical protein 0.005 0.0236 0.0441
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Brugia malayi MH2 domain containing protein 0.0017 0.0035 0.0065
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0022 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0133 0.0249
Echinococcus multilocularis Smad4 0.0017 0.0035 0.0035
Giardia lamblia DINP protein human, muc B family 0.0019 0.0049 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Entamoeba histolytica cysteine proteinase, putative 0.0666 0.3918 0.7099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Echinococcus multilocularis smad 0.0017 0.0035 0.0035
Mycobacterium tuberculosis Probable reductase 0.0108 0.0579 0.2146
Schistosoma mansoni smad1 5 8 and 0.0017 0.0035 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0666 0.3918 0.731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0153 0.0852 0.1512
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.00000027528 0.00000051397
Schistosoma mansoni hypothetical protein 0.0312 0.1804 0.3368
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0062
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0396 0.0987
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0033 0.0085
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0157 0.0376
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0022 0.0045
Toxoplasma gondii patched family protein 0.0012 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0042
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0852 0.159
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.1682 0.1682
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.012 0.0207
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0033 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0028 0.0049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0024
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0167 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0029 0.0054
Onchocerca volvulus Huntingtin homolog 0.0375 0.2179 0.5562
Onchocerca volvulus 0.0014 0.0022 0.0057
Schistosoma mansoni cathepsin B (C01 family) 0.0153 0.0852 0.159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0035 0.0065
Schistosoma mansoni microtubule-associated protein tau 0.082 0.4839 0.9035
Entamoeba histolytica cysteine proteinase, putative 0.0386 0.2243 0.4047
Onchocerca volvulus 0.0014 0.0022 0.0057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0028 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0334 0.0624
Echinococcus granulosus Niemann Pick C1 protein 0.0204 0.1158 0.2162
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0133 0.0249
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0029 0.0054
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0218 0.0406
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0022 0.0022
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0028 0.0036
Schistosoma mansoni cathepsin s 0.0233 0.1327 0.2478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.025 0.1431 0.1431
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0852 0.1512
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Echinococcus multilocularis lamin dm0 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Echinococcus granulosus dna polymerase kappa 0.0019 0.0049 0.0091
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0022 0.0024
Plasmodium falciparum thioredoxin reductase 0.0016 0.0033 0.006
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0022 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0133 0.034
Schistosoma mansoni patched 1 0.0088 0.046 0.0859
Loa Loa (eye worm) hypothetical protein 0.0375 0.2179 0.4068
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0153 0.0852 0.2154
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Trichomonas vaginalis heat shock protein, putative 0.0016 0.003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.023 0.0565
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0028 0.0068
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0153 0.0852 0.1494
Giardia lamblia Cysteine protease 0.0153 0.0852 0.1494
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0016 0.003 0.0015
Brugia malayi glutathione reductase 0.0047 0.0218 0.0406
Loa Loa (eye worm) hypothetical protein 0.0088 0.046 0.0859
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Toxoplasma gondii thioredoxin reductase 0.0047 0.0218 0.0555
Echinococcus multilocularis Niemann Pick C1 protein 0.0204 0.1158 0.1158
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0029 0.0054
Loa Loa (eye worm) cathepsin B 0.0386 0.2245 0.4191
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0022 0.0042
Loa Loa (eye worm) glutathione reductase 0.0047 0.0218 0.0406
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0033 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.023 0.0379
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0666 0.3918 0.7314
Loa Loa (eye worm) hypothetical protein 0.0149 0.0826 0.1543
Loa Loa (eye worm) hypothetical protein 0.0375 0.2179 0.4068
Schistosoma mansoni cathepsin F (C01 family) 0.0666 0.3918 0.7314
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0396 0.0987
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0396 0.0723
Schistosoma mansoni cathepsin F (C01 family) 0.0433 0.2526 0.4717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Giardia lamblia Cysteine protease 0.0153 0.0852 0.1494
Brugia malayi hypothetical protein 0.0375 0.2179 0.4068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.065 0.2417
Trypanosoma brucei unspecified product 0.0013 0.0014 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0033 0.0022
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0022 0.0042
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0907 0.5356 1
Toxoplasma gondii patched family protein 0.0012 0.001 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0095 0.0177
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0207
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0022 0.0033
Onchocerca volvulus 0.0666 0.3918 1
Schistosoma mansoni ran 0.0022 0.0065 0.0121
Loa Loa (eye worm) heat shock protein 75 0.0016 0.003 0.0057
Toxoplasma gondii patched family protein 0.0012 0.001 0.0025
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0029 0.0054
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0065 0.0057
Brugia malayi tailless protein 0.0016 0.0029 0.0054
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0133 0.034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0133 0.0249
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.065 0.2417
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.004 0.0075
Echinococcus granulosus snurportin 1 0.0312 0.1804 0.3368
Brugia malayi conserved hypotetical protein 0.0016 0.0029 0.0054
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0396 0.0987
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Treponema pallidum heat shock protein 90 0.0031 0.012 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0153 0.0852 0.159
Echinococcus multilocularis protein patched 0.0088 0.046 0.046
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0153 0.0852 0.159
Loa Loa (eye worm) hypothetical protein 0.0107 0.0578 0.108
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.046 0.0859
Brugia malayi MH1 domain containing protein 0.0017 0.0035 0.0065
Brugia malayi Patched protein homolog 1 0.0012 0.001 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0133 0.0249
Echinococcus multilocularis expressed conserved protein 0.0192 0.1084 0.1084
Brugia malayi Cathepsin L-like precursor 0.0433 0.2526 0.4717
Brugia malayi isocitrate dehydrogenase 0.0015 0.0028 0.0053
Brugia malayi Smad1 0.0017 0.0035 0.0065
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0153 0.0852 0.1512
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Entamoeba histolytica cysteine protease, putative 0.0153 0.0852 0.1512
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0907 0.5356 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0078 0.0101
Loa Loa (eye worm) jmjC domain-containing protein 0.0252 0.1442 0.2693
Onchocerca volvulus Cathepsin L homolog 0.0666 0.3918 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0029 0.0054
Brugia malayi jmjC domain containing protein 0.0067 0.0334 0.0624
Brugia malayi glutaminase DH11.1 0.0862 0.5088 0.9499
Echinococcus granulosus expressed conserved protein 0.0192 0.1084 0.2023
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0065 0.014
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0069 0.0346 0.0346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0203 0.0379
Toxoplasma gondii cathepsin B 0.0386 0.2245 0.573
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0065 0.0104
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0321 0.0798
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0153 0.0852 0.2154
Echinococcus granulosus jumonji domain containing 1A 0.0067 0.0334 0.0624
Schistosoma mansoni survival motor neuron protein 0.0049 0.0229 0.0427
Leishmania major GTP-binding protein, putative 0.0022 0.0065 0.0142
Brugia malayi hypothetical protein 0.0017 0.004 0.0075
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.00000027528 0.00000027528
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0033 0.0022
Plasmodium vivax heat shock protein, putative 0.0016 0.003 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0049 0.0048
Plasmodium vivax vivapain-1 0.0386 0.2243 0.5715
Echinococcus multilocularis phd:f box containing protein 0.0067 0.0334 0.0334
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0028 0.0028
Loa Loa (eye worm) glutaminase 2 0.0862 0.5088 0.9499
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0133 0.0133
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0233 0.1327 0.2478
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0028 0.0053
Schistosoma mansoni hypothetical protein 0.0085 0.0441 0.0824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.0011
Plasmodium vivax vivapain-2 0.0666 0.3918 1
Echinococcus granulosus heat shock protein 90 0.0031 0.012 0.0224
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0035 0.0065
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0065 0.0121
Echinococcus granulosus microtubule associated protein 2 0.082 0.4839 0.9035
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0065 0.014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0291
Echinococcus granulosus dna polymerase eta 0.0019 0.0049 0.0091
Schistosoma mansoni hypothetical protein 0.0085 0.0441 0.0824
Schistosoma mansoni phd/f-box containing protein 0.0067 0.0334 0.0624
Trichomonas vaginalis heat shock protein, putative 0.0031 0.012 0.0178
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0157 0.0378
Leishmania major cathepsin L-like protease 0.0666 0.3918 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0291
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0049 0.0048
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0204 0.1158 0.2069
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0067 0.0334 0.0624
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0156 0.0373
Brugia malayi hypothetical protein 0.005 0.0233 0.0435
Schistosoma mansoni hypothetical protein 0.0085 0.0441 0.0824
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0932 0.5509 1
Onchocerca volvulus 0.0035 0.0143 0.0365
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Plasmodium vivax vivapain-3 0.0386 0.2243 0.5715
Loa Loa (eye worm) endoplasmin 0.0039 0.0167 0.0311
Loa Loa (eye worm) hypothetical protein 0.0233 0.1327 0.2478
Giardia lamblia Cysteine protease 0.0153 0.0852 0.1494
Loa Loa (eye worm) hypothetical protein 0.024 0.1371 0.2559
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0852 0.1494
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0033 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0133 0.0249
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0049 0.0074
Leishmania major hypothetical protein, conserved 0.0077 0.0396 0.0989
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Mycobacterium ulcerans glutaminase 0.0862 0.5088 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0156 0.0263
Leishmania major hypothetical protein, conserved 0.0067 0.0334 0.0832
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0157 0.04
Echinococcus multilocularis heat shock protein 0.0039 0.0167 0.0167
Entamoeba histolytica cysteine protease, putative 0.0666 0.3918 0.7099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0852 0.1512
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0153 0.0852 0.2154
Brugia malayi Cathepsin L-like precursor 0.0666 0.3918 0.7314
Onchocerca volvulus Protein patched homolog 0.0012 0.001 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.023 0.0379
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0133 0.0133
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0153 0.0852 0.159
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Plasmodium vivax unspecified product 0.0233 0.1327 0.3371
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0028 0.0053
Brugia malayi MH2 domain containing protein 0.0017 0.0035 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0062
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0153 0.0852 0.2154
Plasmodium falciparum thioredoxin reductase 0.0047 0.0218 0.0531
Loa Loa (eye worm) hypothetical protein 0.0153 0.0852 0.159
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0022 0.0057
Schistosoma mansoni hypothetical protein 0.0166 0.0926 0.1729
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Echinococcus granulosus cathepsin L 0.0386 0.2243 0.4188
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0067 0.0334 0.0624
Brugia malayi hypothetical protein 0.0016 0.0029 0.0054
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0177 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Echinococcus multilocularis heat shock protein 90 0.0031 0.012 0.012
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0218 0.039
Loa Loa (eye worm) hypothetical protein 0.0233 0.1327 0.2478
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0321 0.059
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0049 0.0091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0666 0.3918 0.3918
Onchocerca volvulus 0.005 0.0236 0.0602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Plasmodium vivax serine-repeat antigen (SERA) 0.0153 0.0852 0.2154
Trypanosoma cruzi cysteine protease, putative 0.0386 0.2243 0.4178
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0167 0.0403
Echinococcus granulosus geminin 0.0166 0.0926 0.1729
Entamoeba histolytica cysteine proteinase, putative 0.0433 0.2526 0.4563
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.012 1
Echinococcus granulosus Protein patched homolog 1 0.0088 0.046 0.0859
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.1239 0.3163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0144 0.0504
Loa Loa (eye worm) Smad1 0.0017 0.0035 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0133 0.0249
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0033 0.0062
Treponema pallidum fructose-bisphosphate aldolase 0.0932 0.5509 1
Brugia malayi MH2 domain containing protein 0.0243 0.1391 0.2597
Onchocerca volvulus 0.0012 0.001 0.0025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0033 0.0045
Brugia malayi hypothetical protein 0.0016 0.0029 0.0054
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Giardia lamblia Cathepsin L precursor 0.0153 0.0852 0.1494
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0029 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1391 0.2597
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Loa Loa (eye worm) glutaminase 0.0862 0.5088 0.9499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0133 0.0249
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0171 0.0272
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.023 0.041
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0433 0.2526 0.4717
Brugia malayi ecdysteroid receptor 0.0033 0.0133 0.0249
Brugia malayi Cathepsin L-like precursor 0.0666 0.3918 0.7314
Brugia malayi protein C24B5.3 0.0012 0.001 0.0019
Schistosoma mansoni cathepsin F (C01 family) 0.0666 0.3918 0.7314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0133 0.0249
Plasmodium falciparum serine repeat antigen 7 0.0153 0.0852 0.2154
Schistosoma mansoni Smad4 0.0017 0.0035 0.0065
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0133 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Brugia malayi cathepsin F-like cysteine proteinase 0.0153 0.0852 0.159
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0167 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0852 0.1512
Plasmodium falciparum serine repeat antigen 1 0.0153 0.0852 0.2154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0177
Toxoplasma gondii cathepsin CPL 0.0666 0.3918 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0153 0.0852 0.159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0153 0.0852 0.1512
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0029 0.0054
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0065 0.0065
Brugia malayi CHE-14 protein 0.0088 0.046 0.0859
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0666 0.3918 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0907 0.5356 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0321 0.059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0029 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0101
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0666 0.3918 0.7314
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Loa Loa (eye worm) DR-78 0.0016 0.0029 0.0054
Plasmodium falciparum serine repeat antigen 4 0.0153 0.0852 0.2154
Onchocerca volvulus 0.0666 0.3918 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0433 0.2526 0.4708
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0396 0.101
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.025 0.1431 0.2671
Brugia malayi hypothetical protein 0.024 0.1371 0.2559
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0386 0.2245 0.4191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0203 0.0379
Echinococcus multilocularis heat shock protein 90 0.0039 0.0167 0.0167
Onchocerca volvulus 0.0012 0.001 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.0386 0.2243 0.4188
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0101
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0033 0.0062
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0035 0.0035
Onchocerca volvulus 0.0049 0.023 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.023 0.041
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0067 0.0334 0.0608
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0249
Echinococcus multilocularis geminin 0.0166 0.0926 0.0926
Plasmodium vivax unspecified product 0.0153 0.0852 0.2154
Plasmodium falciparum serine repeat antigen 2 0.0153 0.0852 0.2154
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0133 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0021 0.0039
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0009 0.0023
Echinococcus granulosus JmjC domain containing protein 4 0.0067 0.0334 0.0624
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0153 0.0852 0.159
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Echinococcus granulosus Smad4 0.0017 0.0035 0.0065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0133 0.0133
Schistosoma mansoni ran 0.0022 0.0065 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0133 0.0249
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0033 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0133 0.0133
Trypanosoma brucei unspecified product 0.0019 0.0049 0.0101
Echinococcus multilocularis lysine specific demethylase 6a 0.0067 0.0334 0.0334
Echinococcus granulosus cathepsin l1 0.0433 0.2526 0.4717
Brugia malayi Patched family protein 0.0012 0.001 0.0019
Mycobacterium ulcerans heat shock protein 90 0.0031 0.012 0.0193
Loa Loa (eye worm) hypothetical protein 0.0067 0.0334 0.0624
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0455 0.2659 0.5205
Trypanosoma cruzi cysteine peptidase, putative 0.0386 0.2243 0.4178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0203 0.0203
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0029 0.0029
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0035 0.0065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0386 0.2243 0.4188
Schistosoma mansoni hypothetical protein 0.0085 0.0441 0.0824
Loa Loa (eye worm) hypothetical protein 0.0153 0.0852 0.159
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.023 0.0565
Plasmodium falciparum serine repeat antigen 3 0.0153 0.0852 0.2154
Echinococcus multilocularis cathepsin L 0.0386 0.2243 0.2243
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0348 0.065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.004 0.0075
Giardia lamblia Cathepsin B precursor 0.0153 0.0852 0.1494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0153 0.0852 0.1512
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0396 0.0723
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0029 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0074
Schistosoma mansoni hypothetical protein 0.0494 0.2888 0.5393
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0208 0.1177 0.2197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Brugia malayi jmjC domain containing protein 0.0067 0.0334 0.0624
Echinococcus multilocularis cysteine protease 0.0666 0.3918 0.3918
Brugia malayi heat shock protein 90 0.0039 0.0167 0.0311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0049 0.0091
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0153 0.0852 0.2154
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0932 0.5509 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0091
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0049 0.0091
Leishmania major importin beta-1 subunit, putative 0.0024 0.0078 0.0175
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0049 0.0101
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0049 0.0049
Echinococcus granulosus endoplasmin 0.0031 0.012 0.0224
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0348 0.065
Schistosoma mansoni cathepsin C 0.0153 0.0852 0.159
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0022 0.0045
Leishmania major DNA polymerase eta, putative 0.0019 0.0049 0.0101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0028 0.0028
Loa Loa (eye worm) cysteine protease 0.0666 0.3918 0.7314
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0579 0.211
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0033 0.0088
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0049 0.0101
Brugia malayi steroid hormone receptor 0.0033 0.0133 0.0249
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0067 0.0334 0.0854
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0291
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0022 0.0045
Loa Loa (eye worm) hypothetical protein 0.0433 0.2526 0.4717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0386 0.2243 0.4047
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0157 0.0376
Trypanosoma cruzi cruzipain precursor, putative 0.0233 0.1327 0.2465
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0013 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0133 0.0249
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.023 0.083
Schistosoma mansoni hypothetical protein 0.0049 0.0229 0.0427
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Trypanosoma brucei heat shock protein, putative 0.0039 0.0167 0.0403
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.012 0.0414
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0386 0.2243 0.4188
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0666 0.3918 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0203 0.0379
Brugia malayi AMP-binding enzyme family protein 0.0049 0.023 0.043
Giardia lamblia Cathepsin L precursor 0.0153 0.0852 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.3918 0.7099
Entamoeba histolytica hypothetical protein 0.0024 0.0078 0.0101
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0321 0.0321
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0078 0.0128
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0386 0.2245 0.4181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0133 0.0249
Onchocerca volvulus 0.0666 0.3918 1
Onchocerca volvulus 0.0012 0.001 0.0025
Echinococcus granulosus intermediate filament protein 0.0027 0.0095 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0666 0.3918 0.7099
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0153 0.0852 0.1512
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0171 0.0415
Brugia malayi jmjC domain containing protein 0.0067 0.0334 0.0624
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0075
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0321 0.0599
Schistosoma mansoni hypothetical protein 0.0069 0.0348 0.065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0172
Giardia lamblia Cathepsin L-like protease 0.0153 0.0852 0.1494
Toxoplasma gondii preprocathepsin c precursor, putative 0.0153 0.0852 0.2174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0133 0.0249
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0035 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0321 0.059
Brugia malayi AMP-binding enzyme family protein 0.0049 0.023 0.043
Schistosoma mansoni endoplasmin 0.0039 0.0167 0.0311
Giardia lamblia Cathepsin L precursor 0.0153 0.0852 0.1494
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0167 0.0426
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.003 0.0078
Onchocerca volvulus 0.0027 0.0095 0.0242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0203 0.0379
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0321 0.0599
Brugia malayi cathepsin F-like cysteine proteinase 0.0233 0.1327 0.2478
Entamoeba histolytica cysteine protease, putative 0.0386 0.2243 0.4047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0133 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0852 0.1512
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.004 0.004
Brugia malayi nuclear receptor RXR 0.0017 0.004 0.0075
Plasmodium falciparum heat shock protein 90 0.0039 0.0167 0.0401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0907 0.5356 1
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0167 0.0263
Leishmania major heat shock protein 83-1 0.0039 0.0167 0.0403
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0386 0.2243 0.5716
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0167 0.0403
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0028 0.0049

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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