Detailed information for compound 1360346

Basic information

Technical information
  • TDR Targets ID: 1360346
  • Name: [2-(cyclopropylamino)-2-oxoethyl] 3-(3-chloro phenyl)prop-2-enoate
  • MW: 279.719 | Formula: C14H14ClNO3
  • H donors: 1 H acceptors: 2 LogP: 2.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CC1)COC(=O)/C=C/c1cccc(c1)Cl
  • InChi: 1S/C14H14ClNO3/c15-11-3-1-2-10(8-11)4-7-14(18)19-9-13(17)16-12-5-6-12/h1-4,7-8,12H,5-6,9H2,(H,16,17)/b7-4+
  • InChiKey: AXUCYIBZKUPMDP-QPJJXVBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(cyclopropylamino)-2-oxoethyl] (E)-3-(3-chlorophenyl)prop-2-enoate
  • [2-(cyclopropylamino)-2-oxo-ethyl] (E)-3-(3-chlorophenyl)prop-2-enoate
  • [2-(cyclopropylamino)-2-oxo-ethyl] 3-(3-chlorophenyl)prop-2-enoate
  • (E)-3-(3-chlorophenyl)prop-2-enoic acid [2-(cyclopropylamino)-2-oxoethyl] ester
  • 3-(3-chlorophenyl)prop-2-enoic acid [2-(cyclopropylamino)-2-oxoethyl] ester
  • (E)-3-(3-chlorophenyl)acrylic acid [2-(cyclopropylamino)-2-keto-ethyl] ester
  • 3-(3-chlorophenyl)acrylic acid [2-(cyclopropylamino)-2-keto-ethyl] ester
  • ZINC03394089
  • T5400412

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0064 0.0116 0.0101
Trypanosoma cruzi cdc2-related kinase 3 0.0111 0.0568 0.2485
Echinococcus granulosus Immunoglobulin 0.0092 0.038 0.0366
Echinococcus granulosus cyclin dependent kinase 0.0111 0.0568 0.0554
Echinococcus granulosus roundabout 2 0.0058 0.0055 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0568 0.2616
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.026 0.1999 0.1987
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.0151 0.068
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.006 0.0072 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.067 0.309
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0094 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Echinococcus granulosus tyrosine kinase 0.0111 0.0566 0.0552
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0075 0.0215 0.0782
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0357 0.2936 0.3613
Trypanosoma cruzi cdc2-related kinase 3 0.0111 0.0568 0.2485
Echinococcus granulosus SHC transforming protein 3 0.0064 0.0116 0.0101
Echinococcus granulosus ephrin type A receptor 4 A 0.0116 0.061 0.0596
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0138 0.0823 0.1009
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0329 0.2659 0.2915
Loa Loa (eye worm) hypothetical protein 0.0088 0.0342 0.0361
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.005 0.0211
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0055 0.0044
Echinococcus granulosus NCK adaptor protein 0.0122 0.0668 0.0654
Trypanosoma cruzi casein kinase, putative 0.006 0.0071 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Loa Loa (eye worm) TK/ROR protein kinase 0.0067 0.0147 0.0145
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.0985 0.1209
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0823 0.3797
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Echinococcus multilocularis Glutaredoxin protein 5 0.0133 0.0777 0.0953
Echinococcus granulosus intersectin 2 0.0059 0.0063 0.0048
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0094 0.021
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0182 0.0306
Echinococcus multilocularis tyrosine protein kinase shark 0.0111 0.0566 0.0692
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0057 0.005 0.0056
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0111 0.0568 0.061
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0071 0.0182 0.0167
Schistosoma mansoni tensin-related 0.0064 0.0116 0.0193
Onchocerca volvulus 0.0088 0.0342 0.0493
Echinococcus granulosus suppressor of cytokine signaling 6 0.0064 0.0116 0.0101
Echinococcus multilocularis growth factor receptor bound protein 2 0.0122 0.0668 0.0818
Echinococcus granulosus SH2 domain containing protein 7 0.0064 0.0116 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Giardia lamblia Kinase, CMGC GSK 0.0122 0.067 0.2901
Brugia malayi protein-tyrosine kinase 0.0057 0.005 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0357 0.2936 0.3613
Brugia malayi Tyrosine-protein kinase abl-1 0.0254 0.1939 0.2121
Onchocerca volvulus Tyrosine kinase homolog 0.0744 0.6657 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0064 0.0116 0.0101
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0063 0.0107 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.1152 0.1982
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0219 0.16 0.1967
Leishmania major protein kinase, putative 0.0066 0.013 0.0384
Onchocerca volvulus 0.0111 0.0566 0.0829
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.013 0.0384
Schistosoma mansoni tyrosine kinase 0.0081 0.0273 0.0463
Trypanosoma cruzi cdc2-related kinase 1 0.0111 0.0568 0.2485
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0111
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0064 0.0116 0.0138
Plasmodium falciparum casein kinase 2, alpha subunit 0.0091 0.0375 0.3415
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0274 0.2135 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0357 0.2936 0.2925
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.0985 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Echinococcus granulosus Protein kinase C brain isozyme 0.0219 0.16 0.1587
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0115 0.0604 0.0649
Loa Loa (eye worm) SH2 domain-containing protein 0.0064 0.0116 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Brugia malayi Variant SH3 domain containing protein 0.0057 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0062 0.0094 0.0111
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0057 0.005 0.0056
Brugia malayi Hr1 repeat family protein 0.0138 0.0823 0.089
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0101 0.047 0.0502
Schistosoma mansoni tensin 0.0064 0.0116 0.0193
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0111 0.0568 0.0554
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.014 0.0844 0.3897
Echinococcus granulosus serine/threonine protein kinase 0.0158 0.1016 0.1003
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0879 0.4062
Echinococcus granulosus fibroblast growth factor receptor 4 0.026 0.1999 0.1987
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0274 0.2135 0.2123
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0357 0.2936 0.3613
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0064 0.0116 0.0101
Echinococcus granulosus casein kinase I alpha 0.006 0.0071 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0407 0.3418 0.5895
Brugia malayi protein kinase C3,putative 0.0145 0.0892 0.0966
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0064 0.0116 0.0101
Trypanosoma cruzi casein kinase, putative 0.006 0.0071 0.0104
Echinococcus granulosus serine:threonine protein kinase 0.0106 0.052 0.0505
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0057 0.005 0.0035
Schistosoma mansoni cell adhesion molecule 0.0129 0.0739 0.1269
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Echinococcus granulosus mitogen activated protein kinase 3 0.0074 0.0205 0.019
Echinococcus granulosus defective proboscis extension response 0.0092 0.038 0.0366
Schistosoma mansoni tensin 0.0064 0.0116 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.1152 0.1982
Schistosoma mansoni suppressor of cytokine signaling 0.0064 0.0116 0.0193
Entamoeba histolytica casein kinase, putative 0.0091 0.0375 0.1718
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.013 0.0384
Entamoeba histolytica hypothetical protein 0.0115 0.0604 0.2781
Schistosoma mansoni hypothetical protein 0.0066 0.013 0.0218
Echinococcus multilocularis casein kinase I alpha 0.006 0.0071 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0075 0.0215 0.0976
Brugia malayi casein kinase 1, delta 0.006 0.0071 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0072 0.0116
Trypanosoma cruzi aurora B kinase, putative 0.014 0.0844 0.3809
Schistosoma mansoni nck2/grb4 0.0122 0.0668 0.1146
Brugia malayi Protein kinase domain containing protein 0.0071 0.0182 0.0184
Loa Loa (eye worm) thyroid receptor interactor 0.0057 0.005 0.0038
Trichomonas vaginalis STE family protein kinase 0.0076 0.0229 0.1041
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0094 0.0212
Onchocerca volvulus 0.0064 0.0116 0.0152
Echinococcus granulosus tyrosine protein kinase Src64B 0.0357 0.2936 0.2925
Onchocerca volvulus 0.0057 0.005 0.0052
Loa Loa (eye worm) AUR protein kinase 0.014 0.0844 0.0914
Loa Loa (eye worm) hypothetical protein 0.0287 0.2259 0.2473
Giardia lamblia Kinase, CMGC GSK 0.0122 0.067 0.2901
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0057 0.005 0.0035
Brugia malayi Fes/CIP4 homology domain containing protein 0.0057 0.005 0.0038
Echinococcus multilocularis serine threonine protein kinase 0.0182 0.1246 0.153
Loa Loa (eye worm) hypothetical protein 0.0106 0.0517 0.0554
Schistosoma mansoni shc transforming protein 0.0064 0.0116 0.0193
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0111 0.0568 0.2485
Brugia malayi Variant SH3 domain containing protein 0.0057 0.005 0.0038
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0151 0.0955 0.1036
Entamoeba histolytica protein kinase, putative 0.0076 0.0229 0.1041
Brugia malayi MAP kinase sur-1 0.0074 0.0205 0.0209
Schistosoma mansoni tyrosine kinase 0.048 0.4112 0.7095
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0646 0.298
Toxoplasma gondii AGC kinase 0.0062 0.0094 0.0111
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0199 0.1416 0.1403
Loa Loa (eye worm) hypothetical protein 0.0096 0.0422 0.0448
Plasmodium falciparum NIMA related kinase 1 0.013 0.0747 0.7613
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Loa Loa (eye worm) AGC/AKT protein kinase 0.0277 0.2159 0.2364
Schistosoma mansoni protein kinase 0.0076 0.0229 0.0388
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0494 0.4249 0.5232
Schistosoma mansoni tyrosine kinase 0.0091 0.0369 0.0629
Echinococcus multilocularis tyrosine protein kinase Abl 0.0254 0.1939 0.2384
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0191 0.1333 0.1985
Loa Loa (eye worm) hypothetical protein 0.0131 0.0753 0.0814
Echinococcus multilocularis endophilin A3 0.0057 0.005 0.0056
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0111 0.0568 0.2485
Schistosoma mansoni eps8-related protein 0.0057 0.005 0.0078
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0079
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0155 0.0985 0.107
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0122 0.067 0.2975
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.013 0.0583
Echinococcus granulosus roundabout 2 0.015 0.0938 0.0924
Schistosoma mansoni tyrosine kinase 0.048 0.4112 0.7095
Brugia malayi Protein kinase domain 0.0076 0.0229 0.0235
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0055 0.0044
Echinococcus multilocularis protein kinase shaggy 0.0122 0.067 0.0821
Giardia lamblia Kinase, CMGC CDK 0.0111 0.0568 0.2406
Echinococcus multilocularis cyclin dependent kinase 1 0.0111 0.0568 0.0695
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0076 0.0229 0.0214
Giardia lamblia Kinase, NEK 0.013 0.0747 0.3275
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0182 0.0824
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0055 0.0044
Schistosoma mansoni tyrosine kinase 0.0655 0.5794 1
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0092 0.038 0.0403
Echinococcus granulosus serine:threonine protein kinase Chk2 0.006 0.0072 0.0057
Echinococcus granulosus protein kinase c iota type 0.0264 0.2035 0.2022
Echinococcus granulosus hypothetical protein 0.0064 0.0116 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.16 0.2756
Echinococcus granulosus c-Jun N-terminal kinases 0.0268 0.2073 0.2061
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0122 0.067 0.2948
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Brugia malayi Protein kinase domain containing protein 0.0184 0.1265 0.1378
Loa Loa (eye worm) AGC/NDR protein kinase 0.0138 0.0823 0.089
Schistosoma mansoni apoptosis stimulating of P53 0.0057 0.005 0.0078
Brugia malayi Protein kinase domain containing protein 0.0111 0.0566 0.0607
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0172 0.1152 0.1415
Onchocerca volvulus 0.0333 0.2703 0.4047
Brugia malayi Spectrin alpha chain 0.0057 0.005 0.0038
Echinococcus multilocularis mitogen activated protein kinase 0.0074 0.0205 0.0248
Loa Loa (eye worm) TK protein kinase 0.0281 0.2198 0.2407
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0064 0.0116 0.0152
Schistosoma mansoni serine/threonine-protein kinase 0.0158 0.1016 0.1748
Echinococcus granulosus c src tyrosine kinase 0.0168 0.1118 0.1104
Giardia lamblia Kinase, STE STE20 0.0076 0.0229 0.0762
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Leishmania major protein kinase A catalytic subunit 0.0062 0.0094 0.0212
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Trypanosoma cruzi polo-like protein kinase, putative 0.0274 0.2135 1
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0823 0.1413
Echinococcus granulosus casein kinase I alpha 0.006 0.0071 0.0056
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0094 0.098
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0071 0.0311
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0115 0.0607 0.2672
Onchocerca volvulus Putative cortactin 0.0057 0.005 0.0052
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0274 0.2135 0.2627
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Echinococcus granulosus mitogen activated protein kinase 11 0.0155 0.0985 0.0972
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Giardia lamblia Kinase, AGC AKT 0.0109 0.055 0.2319
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0823 0.1413
Brugia malayi serine/threonine-protein kinase PAK 7 0.0233 0.174 0.1902
Echinococcus granulosus SH2 motif 0.0064 0.0116 0.0101
Brugia malayi Variant SH3 domain containing protein 0.0072 0.0186 0.0188
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0057 0.005 0.0038
Entamoeba histolytica protein kinase, putative 0.0083 0.0298 0.1362
Echinococcus multilocularis NCK adaptor protein 0.0122 0.0668 0.0818
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.067 0.309
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0064 0.0116 0.0111
Onchocerca volvulus 0.0111 0.0566 0.0829
Trichomonas vaginalis AGC family protein kinase 0.014 0.0844 0.3897
Schistosoma mansoni serine/threonine kinase 0.0138 0.0823 0.1413
Echinococcus multilocularis serine:threonine protein kinase N2 0.0138 0.0823 0.1009
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0109 0.055 0.059
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0133 0.0777 0.0763
Loa Loa (eye worm) guanylate kinase 0.006 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0128 0.0729 0.0787
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0191 0.1333 0.1453
Onchocerca volvulus 0.0111 0.0566 0.0829
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0147 0.0911 0.0897
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.1333 0.2295
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0071 0.0182 0.0219
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0092 0.038 0.065
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0071 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0333 0.2703 0.4661
Schistosoma mansoni protein kinase 0.0233 0.1739 0.2995
Echinococcus granulosus neuroglian 0.0112 0.0579 0.0565
Echinococcus multilocularis myosin iiia 0.0075 0.0215 0.0259
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0228 0.1693 0.168
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0139 0.0837 0.0823
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0067 0.0147 0.0132
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0997 0.9085 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0138 0.0823 0.0809
Trichomonas vaginalis AGC family protein kinase 0.014 0.0844 0.3897
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0079
Echinococcus granulosus tyrosine protein kinase Fyn 0.0357 0.2936 0.2925
Echinococcus multilocularis signal transduction protein lnk realted 0.0064 0.0116 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.052 0.2391
Echinococcus granulosus neuroglian 0.0058 0.0055 0.004
Trypanosoma brucei protein kinase, putative 0.0074 0.0205 0.0737
Echinococcus granulosus fch and double sh3 domains protein 2 0.0057 0.005 0.0035
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0139 0.0837 0.1027
Echinococcus granulosus mitogen activated protein kinase 0.0074 0.0205 0.019
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0111
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0058 0.0055 0.0063
Echinococcus multilocularis death associated protein kinase 1 0.0896 0.8117 1
Schistosoma mansoni adapter molecule crk 0.0122 0.0668 0.1146
Leishmania major protein kinase A catalytic subunit isoform 2 0.0062 0.0094 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0604 0.1035
Echinococcus multilocularis casein kinase I alpha 0.006 0.0071 0.0083
Entamoeba histolytica cell division protein kinase 2, putative 0.0111 0.0568 0.2616
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0057 0.005 0.0078
Entamoeba histolytica protein kinase, putative 0.0059 0.0061 0.0264
Loa Loa (eye worm) hypothetical protein 0.0106 0.0517 0.0554
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0094 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0191 0.1333 0.1453
Schistosoma mansoni hypothetical protein 0.0372 0.3073 0.5301
Echinococcus multilocularis neuroglian 0.0058 0.0055 0.0063
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0092 0.038 0.0464
Brugia malayi Temporarily assigned gene name protein 59 0.0139 0.0833 0.0901
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0334 0.2712 0.3338
Schistosoma mansoni formin binding protein and related proteins 0.0057 0.005 0.0078
Brugia malayi Protein kinase domain containing protein 0.0201 0.1433 0.1564
Trichomonas vaginalis STE family protein kinase 0.0076 0.0229 0.1041
Loa Loa (eye worm) TK protein kinase 0.03 0.2384 0.2611
Brugia malayi Peripheral plasma membrane protein CASK 0.006 0.0071 0.0061
Loa Loa (eye worm) TK protein kinase 0.0236 0.1766 0.193
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.1416 0.2438
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.026 0.1999 0.2459
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.067 0.309
Brugia malayi Immunoglobulin I-set domain containing protein 0.0281 0.2198 0.2407
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0094 0.0087
Brugia malayi Variant SH3 domain containing protein 0.0057 0.005 0.0038
Entamoeba histolytica PH domain containing protein kinase, putative 0.0158 0.1016 0.4696
Schistosoma mansoni protein kinase 0.014 0.0844 0.145
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0357 0.2936 0.3613
Brugia malayi Variant SH3 domain containing protein 0.0057 0.005 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0823 0.3797
Echinococcus granulosus cyclin dependent kinase 1 0.0111 0.0568 0.0554
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0072 0.0186 0.0188
Brugia malayi Variant SH3 domain containing protein 0.0057 0.005 0.0038
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0071 0.0062
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0357 0.2936 0.2925
Plasmodium vivax serine/threonine protein kinase 6, putative 0.014 0.0844 0.8798
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0168 0.1118 0.1923
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0138 0.0823 0.0809
Trichomonas vaginalis STE family protein kinase 0.0076 0.0229 0.1041
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0233 0.174 0.1902
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Loa Loa (eye worm) TK/INSR protein kinase 0.048 0.4112 0.4517
Schistosoma mansoni neuroglian 0.0058 0.0055 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.067 0.309
Trypanosoma brucei rac serine-threonine kinase, putative 0.0277 0.2159 1
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Onchocerca volvulus 0.0078 0.0253 0.0357
Echinococcus multilocularis rac serine:threonine kinase 0.0158 0.1016 0.1247
Echinococcus granulosus src region 0.0057 0.005 0.0035
Schistosoma mansoni signal transduction protein lnk-related 0.0064 0.0116 0.0193
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Entamoeba histolytica protein kinase , putative 0.014 0.0844 0.3897
Echinococcus multilocularis roundabout 2 0.015 0.0938 0.1151
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Schistosoma mansoni cell adhesion molecule 0.0058 0.0055 0.0088
Echinococcus granulosus tyrosine protein kinase HCK 0.0236 0.1766 0.1753
Leishmania major protein kinase, putative 0.0075 0.0215 0.0791
Loa Loa (eye worm) hypothetical protein 0.0092 0.0383 0.0405
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0075 0.0215 0.0976
Echinococcus multilocularis epidermal growth factor receptor 0.0431 0.364 0.4482
Echinococcus multilocularis SH2 motif 0.0064 0.0116 0.0138
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0063 0.0107 0.0126
Echinococcus multilocularis rho associated protein kinase 0.0333 0.2703 0.3326
Loa Loa (eye worm) hypothetical protein 0.0096 0.0422 0.0448
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0233 0.1739 0.1726
Echinococcus granulosus tyrosine protein kinase Src42A 0.0357 0.2936 0.2925
Brugia malayi Stress-activated protein kinase jnk-1 0.0268 0.2073 0.2269
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0091 0.0375 0.3905
Brugia malayi phosphoinositide-dependent protein kinase I 0.0071 0.0182 0.0184
Brugia malayi SRC-1 0.0357 0.2936 0.322
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Echinococcus granulosus signal transduction protein lnk realted 0.0064 0.0116 0.0101
Brugia malayi serine/threonine protein kinase 6 0.014 0.0844 0.0914
Onchocerca volvulus 0.0111 0.0566 0.0829
Trypanosoma cruzi casein kinase II, putative 0.0091 0.0375 0.1558
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0357 0.2936 0.2925
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0074 0.0205 0.0745
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0122 0.067 0.0722
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0155 0.0985 0.4486
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0067 0.0147 0.0175
Trypanosoma brucei cdc2-related kinase 3 0.0111 0.0568 0.2457
Echinococcus granulosus cyclin dependent kinase 5 0.0111 0.0568 0.0554
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.026 0.1996 0.2184
Echinococcus granulosus serine:threonine protein kinase 3 0.026 0.1996 0.1984
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0058 0.0055 0.0063
Loa Loa (eye worm) AUR protein kinase 0.014 0.0844 0.0914
Entamoeba histolytica BAR/SH3 domain containing protein 0.0057 0.005 0.0211
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.013 0.0747 0.7791
Entamoeba histolytica PH domain containing protein kinase, putative 0.0158 0.1016 0.4696
Echinococcus multilocularis aurora kinase A 0.014 0.0844 0.1035
Echinococcus granulosus serine:threonine protein kinase 0.0106 0.052 0.0505
Brugia malayi P38 map kinase family protein 2 0.0155 0.0985 0.107
Echinococcus multilocularis intersectin 2 0.0059 0.0063 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0568 0.2616
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0147 0.0911 0.1117
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0064 0.0116 0.0111
Schistosoma mansoni suppressor of cytokine signaling 0.0064 0.0116 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0094 0.0155
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Echinococcus multilocularis neuroglian 0.0112 0.0579 0.0709
Plasmodium vivax unspecified product 0.0091 0.0375 0.3905
Onchocerca volvulus 0.0314 0.2521 0.3773
Leishmania major casein kinase, putative 0.006 0.0071 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0205 0.0932
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.0985 0.1209
Brugia malayi serine/threonine kinase 12 0.014 0.0844 0.0914
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0062 0.0094 0.0254
Schistosoma mansoni tyrosine kinase 0.0384 0.319 0.5503
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0057 0.005 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0312 0.0532
Brugia malayi protein kinase C II. 0.0176 0.119 0.1295
Echinococcus granulosus dual specificity 0.0115 0.0604 0.0589
Entamoeba histolytica protein kinase, putative 0.0236 0.1766 0.8174
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0228 0.1693 0.185
Schistosoma mansoni vesicular amine transporter 0.0092 0.038 0.065
Echinococcus multilocularis serine:threonine protein kinase 0.0106 0.052 0.0635
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0199 0.1416 0.174
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0407 0.3418 0.3408
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0074 0.0205 0.0659
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Brugia malayi Protein kinase domain containing protein 0.0111 0.0568 0.061
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0058 0.0055 0.0063
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0152 0.0959 1
Schistosoma mansoni tyrosine kinase 0.0384 0.319 0.5503
Echinococcus granulosus tyrosine protein kinase Lyn 0.0376 0.3118 0.3107
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.0985 0.4486
Echinococcus granulosus casein kinase ii subunit alpha 0.0091 0.0375 0.036
Brugia malayi Protein kinase domain containing protein 0.0277 0.2159 0.2364
Loa Loa (eye worm) hypothetical protein 0.0132 0.0769 0.0831
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0138 0.0823 0.089
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0312 0.2498 0.3074
Echinococcus multilocularis casein kinase I delta 0.006 0.0071 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0302 0.0514
Echinococcus granulosus casein kinase I alpha 0.006 0.0071 0.0056
Echinococcus granulosus tyrosine protein kinase Blk 0.03 0.2384 0.2372
Trypanosoma cruzi polo-like protein kinase, putative 0.0274 0.2135 1
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0064 0.0116 0.0152
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0172 0.1152 0.1139
Echinococcus multilocularis hypothetical protein 0.0066 0.013 0.0155
Echinococcus multilocularis cyclin dependent kinase 1 0.0111 0.0568 0.0695
Giardia lamblia Kinase, STE STE20 0.0075 0.0215 0.0694
Echinococcus multilocularis SH2 domain containing protein 7 0.0064 0.0116 0.0138
Echinococcus multilocularis epidermal growth factor receptor 0.0655 0.5794 0.7137
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.006 0.0071 0.0062
Echinococcus granulosus twitchin 0.0131 0.0761 0.0747
Schistosoma mansoni titin 0.0054 0.0015 0.0019
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0101 0.047 0.0574
Echinococcus multilocularis nervana 2 0.0133 0.0777 0.0953
Echinococcus multilocularis protein kinase c epsilon type 0.0176 0.119 0.1461
Brugia malayi SH2 domain containing protein 0.0111 0.0566 0.0607
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0063 0.0103 0.0097
Entamoeba histolytica protein kinase, putative 0.006 0.0072 0.0313
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0431 0.364 0.3631
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0074 0.0205 0.0745
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0057 0.005 0.0038
Schistosoma mansoni hypothetical protein 0.0064 0.0116 0.0193
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0172 0.1152 0.1139
Schistosoma mansoni kinase 0.0294 0.2326 0.401
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0268 0.2073 0.2269
Trichomonas vaginalis AGC family protein kinase 0.014 0.0844 0.3897
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0074 0.0205 0.0745
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0268 0.2073 0.255
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0152 0.0959 0.0946
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0253 0.1934 0.1921
Onchocerca volvulus 0.0064 0.0116 0.0152
Schistosoma mansoni hypothetical protein 0.0066 0.013 0.0218
Brugia malayi intracellular kinase 0.0122 0.067 0.0722
Schistosoma mansoni nephrin 0.0127 0.0716 0.1229
Brugia malayi Protein kinase domain containing protein 0.0085 0.0312 0.0328
Echinococcus granulosus tensin 0.0064 0.0116 0.0101
Brugia malayi tRNA modification GTPase TrmE family protein 0.0064 0.0116 0.0111
Brugia malayi Protein kinase domain containing protein 0.0191 0.1333 0.1453
Loa Loa (eye worm) SH2 domain-containing protein 0.0064 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0106 0.0517 0.0554
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0085 0.0312 0.0328
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0076 0.0229 0.0214
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0111 0.0568 0.061
Toxoplasma gondii AGC kinase 0.0271 0.2102 1
Brugia malayi Protein kinase domain containing protein 0.0111 0.0566 0.0607
Onchocerca volvulus 0.0064 0.0116 0.0152
Schistosoma mansoni cell polarity protein 0.0057 0.005 0.0078
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0602 0.0588
Giardia lamblia Kinase, CMGC MAPK 0.0074 0.0205 0.0648
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0122 0.067 0.0821
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0205 0.0932
Brugia malayi cell division control protein 2 homolog 0.0111 0.0568 0.061
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0057 0.0051 0.0053
Echinococcus granulosus roundabout 2 0.0058 0.0055 0.004
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0647 0.1111
Trypanosoma brucei polo-like protein kinase 0.0274 0.2135 0.9887
Trypanosoma brucei protein kinase, putative 0.0066 0.013 0.038
Echinococcus granulosus nervana 2 0.0133 0.0777 0.0763
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.0312 0.1429
Trichomonas vaginalis STE family protein kinase 0.0075 0.0215 0.0976
Echinococcus granulosus serine:threonine protein kinase 12 B 0.014 0.0844 0.083
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.013 0.038
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0604 0.2781
Onchocerca volvulus 0.0125 0.0697 0.1026
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0064 0.0116 0.0138
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0138 0.0823 0.1009
Echinococcus granulosus NDR protein kinase 0.0138 0.0823 0.0809
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Echinococcus multilocularis tyrosine protein kinase Blk 0.03 0.2384 0.2933
Loa Loa (eye worm) AGC/PKN protein kinase 0.0138 0.0823 0.089
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.012 0.0647 0.0633
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.006 0.0072 0.0057
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0107 0.0524 0.0561
Entamoeba histolytica protein kinase 2, putative 0.0152 0.0959 0.4432
Brugia malayi Protein kinase domain containing protein 0.0138 0.0823 0.089
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0074 0.0205 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0844 0.145
Echinococcus multilocularis Immunoglobulin 0.0092 0.038 0.0464
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0274 0.2135 0.2338
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.03 0.2384 0.2372
Entamoeba histolytica protein kinase, putative 0.0271 0.2102 0.9736
Echinococcus multilocularis tyrosine protein kinase Fyn 0.03 0.2384 0.2933
Schistosoma mansoni tensin 0.0064 0.0116 0.0193
Echinococcus multilocularis 0.0064 0.0116 0.0138
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0057 0.005 0.0078
Loa Loa (eye worm) SRC-1 0.0357 0.2936 0.322
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Brugia malayi map kinase activated protein kinase protein 2 0.0407 0.3418 0.3751
Echinococcus multilocularis casein kinase i 0.006 0.0071 0.0083
Schistosoma mansoni ephrin receptor 0.0116 0.061 0.1047
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0228 0.1693 0.2081
Echinococcus granulosus epidermal growth factor receptor 0.0431 0.364 0.3631
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.0985 0.4486
Schistosoma mansoni sorbin 0.0057 0.005 0.0078
Echinococcus multilocularis nostrin 0.0057 0.005 0.0056
Giardia lamblia Kinase, CMGC CK2 0.0091 0.0375 0.1469
Brugia malayi RhoGAP domain containing protein 0.0101 0.047 0.0502
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0253 0.1934 0.2378
Trypanosoma cruzi cdc2-related kinase 1 0.0111 0.0568 0.2485
Loa Loa (eye worm) hypothetical protein 0.0149 0.0934 0.1013
Echinococcus multilocularis tensin 0.0064 0.0116 0.0138
Entamoeba histolytica protein kinase, putative 0.0122 0.067 0.309
Onchocerca volvulus 0.0069 0.016 0.0218
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0233 0.1739 0.2138
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0092 0.038 0.065
Echinococcus granulosus insulin receptor 0.048 0.4112 0.4103
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0057 0.005 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.16 0.2756
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0094 0.0212
Trypanosoma brucei Casein kinase II 0.0091 0.0375 0.154
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0191 0.1333 0.132
Trichomonas vaginalis STE family protein kinase 0.013 0.0747 0.3449
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.2135 0.368
Brugia malayi ephrin receptor 1 precursor 0.0079 0.026 0.027
Echinococcus granulosus raf serine:threonine protein kinase 0.0084 0.0302 0.0287
Onchocerca volvulus 0.0149 0.0934 0.1383
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0357 0.2936 0.3613
Loa Loa (eye worm) hypothetical protein 0.0186 0.1288 0.1403
Brugia malayi STE20-like kinase MST 0.026 0.1996 0.2184
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0062 0.0094 0.021
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0271 0.2102 0.2301
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0911 0.1565
Giardia lamblia Kinase, PLK 0.0274 0.2135 1
Trypanosoma cruzi casein kinase, putative 0.006 0.0071 0.0104
Entamoeba histolytica casein kinase 1, putative 0.006 0.0071 0.0311
Brugia malayi Protein kinase domain containing protein 0.0115 0.0604 0.0649
Echinococcus granulosus snurportin 1 0.0372 0.3073 0.3063
Echinococcus multilocularis ephrin type A receptor 4 A 0.0116 0.061 0.0747
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0122 0.0668 0.072
Brugia malayi SH2 domain containing protein 0.0111 0.0566 0.0607
Brugia malayi Variant SH3 domain containing protein 0.0057 0.005 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.119 0.2047
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0111 0.0566 0.0552
Onchocerca volvulus 0.0064 0.0116 0.0152
Toxoplasma gondii aurora kinase 0.014 0.0844 0.3805
Schistosoma mansoni sorting nexin 0.0057 0.005 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Schistosoma mansoni dreadlocks/dock 0.0057 0.005 0.0078
Entamoeba histolytica protein kinase, putative 0.0277 0.2159 1
Entamoeba histolytica SH2 domain containing protein 0.0064 0.0116 0.0518
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0155 0.0985 0.4435
Leishmania major protein kinase, putative 0.014 0.0844 0.3809
Echinococcus granulosus Glutaredoxin protein 5 0.0133 0.0777 0.0763
Echinococcus multilocularis insulin receptor 0.048 0.4112 0.5064
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0122 0.067 0.0656
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.006 0.0072 0.0083
Echinococcus multilocularis tyrosine protein kinase Srms 0.03 0.2384 0.2933
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0215 0.0791
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0646 0.298
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0205 0.0932
Brugia malayi Immunoglobulin I-set domain containing protein 0.0838 0.7563 0.8322
Echinococcus granulosus casein kinase I delta 0.006 0.0071 0.0056
Echinococcus granulosus contactin 0.0058 0.0055 0.004
Entamoeba histolytica protein kinase, putative 0.0059 0.0061 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Schistosoma mansoni tyrosine kinase 0.0357 0.2936 0.5063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0039
Echinococcus multilocularis serine:threonine protein kinase 38 0.0138 0.0823 0.1009
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0015 0.0019
Echinococcus granulosus protein kinase C gamma type 0.0182 0.1246 0.1233
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0823 0.3797
Entamoeba histolytica protein kinase, putative 0.0115 0.0604 0.2781
Echinococcus multilocularis casein kinase I alpha 0.006 0.0071 0.0083
Loa Loa (eye worm) hypothetical protein 0.0154 0.0983 0.1067
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.2073 0.3573
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0199 0.1416 0.1545
Echinococcus multilocularis SH2 motif 0.0064 0.0116 0.0138
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0057 0.005 0.0211
Echinococcus multilocularis transfer RNA-Ala 0.0057 0.005 0.0056
Echinococcus granulosus aurora kinase A 0.014 0.0844 0.083
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0106 0.052 0.0556
Brugia malayi C1-like domain containing protein 0.0144 0.0878 0.0952
Brugia malayi hypothetical protein 0.0064 0.0116 0.0111
Loa Loa (eye worm) AUR protein kinase 0.014 0.0844 0.0914
Brugia malayi STAT protein, DNA binding domain containing protein 0.0064 0.0116 0.0111
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0312 0.2498 0.2487
Brugia malayi RNA, U transporter 1 0.0099 0.045 0.048
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Echinococcus multilocularis dual specificity 0.0115 0.0604 0.0739
Trichomonas vaginalis AGC family protein kinase 0.013 0.0747 0.3449
Giardia lamblia Kinase, AGC PKA 0.0062 0.0094 0.0109
Loa Loa (eye worm) TK/ABL protein kinase 0.0334 0.2712 0.2974
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0312 0.0532
Trypanosoma brucei cdc2-related kinase 1 0.0111 0.0568 0.2457
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0147 0.0911 0.0987
Loa Loa (eye worm) hypothetical protein 0.0057 0.0047 0.0035
Loa Loa (eye worm) hypothetical protein 0.0106 0.052 0.0556
Onchocerca volvulus Serine\/threonine kinase homolog 0.0274 0.2135 0.3192
Brugia malayi Variant SH3 domain containing protein 0.0122 0.0668 0.072
Plasmodium falciparum protein kinase, putative 0.0066 0.013 0.0658
Echinococcus granulosus tyrosine kinase 0.03 0.2384 0.2372
Echinococcus multilocularis casein kinase ii subunit alpha 0.0091 0.0375 0.0456
Echinococcus granulosus casein kinase I delta 0.006 0.0071 0.0056
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Trypanosoma brucei casein kinase I, isoform 2 0.006 0.0071 0.0103
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.013 0.0747 0.3329
Trypanosoma brucei aurora B kinase 0.014 0.0844 0.3766
Echinococcus granulosus Spectrin alpha actinin 0.0057 0.005 0.0035
Schistosoma mansoni Dab2-interacting protein-like 0.0057 0.005 0.0078
Echinococcus granulosus N chimaerin 0.0101 0.047 0.0456
Loa Loa (eye worm) hypothetical protein 0.0111 0.0566 0.0607
Schistosoma mansoni tyrosine kinase 0.0357 0.2936 0.5063
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0064 0.0116 0.0193
Echinococcus multilocularis snurportin 1 0.0372 0.3073 0.3783
Echinococcus multilocularis calcium activated potassium channel 0.0085 0.0312 0.038
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0076 0.0229 0.0277
Loa Loa (eye worm) hypothetical protein 0.0125 0.0697 0.0751
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0071 0.0062
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Echinococcus multilocularis roundabout 2 0.0058 0.0055 0.0063
Schistosoma mansoni tyrosine kinase 0.026 0.1999 0.3446
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0357 0.2936 0.3613
Onchocerca volvulus 0.0064 0.0116 0.0152
Entamoeba histolytica casein kinase, putative 0.006 0.0071 0.0311
Schistosoma mansoni vav2 0.0107 0.0527 0.0903
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Schistosoma mansoni hypothetical protein 0.0064 0.0116 0.0193
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0407 0.3418 0.3751
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.005 0.0211
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Brugia malayi Kinase associated domain 1 family protein 0.0066 0.013 0.0127
Schistosoma mansoni tyrosine kinase 0.0168 0.1118 0.1923
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Trichomonas vaginalis p67phox protein, putative 0.0057 0.005 0.0211
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.014 0.0844 0.1035
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.014 0.0844 0.3897
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0076 0.0229 0.0214
Trichomonas vaginalis AGC family protein kinase 0.0062 0.0094 0.0416
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0064 0.0116 0.0111
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.0668 0.1146
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0122 0.067 0.115
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0152 0.0959 1
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Echinococcus granulosus expressed protein 0.0057 0.005 0.0035
Schistosoma mansoni protein kinase 0.0091 0.0375 0.064
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0115 0.0604 0.2656
Onchocerca volvulus 0.0131 0.0753 0.1112
Plasmodium falciparum protein kinase 5 0.0111 0.0568 0.5593
Echinococcus multilocularis tyrosine kinase 0.0111 0.0566 0.0692
Entamoeba histolytica protein kinase, putative 0.014 0.0844 0.3897
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0057 0.005 0.0056
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0494 0.4249 0.424
Loa Loa (eye worm) hypothetical protein 0.0092 0.0386 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0568 0.0974
Trypanosoma cruzi casein kinase, putative 0.006 0.0071 0.0104
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0094 0.0212
Echinococcus granulosus nervana 2 0.0133 0.0777 0.0763
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0064 0.0116 0.0138
Brugia malayi Protein kinase domain containing protein 0.0111 0.0566 0.0607
Loa Loa (eye worm) hypothetical protein 0.0092 0.038 0.0403
Echinococcus granulosus SH2 motif 0.0064 0.0116 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0824 0.1416
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0191 0.1333 0.1453
Echinococcus multilocularis cyclin dependent kinase 0.0111 0.0568 0.0695
Loa Loa (eye worm) TK/EGFR protein kinase 0.0655 0.5794 0.6372
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0071 0.0311
Echinococcus granulosus growth factor receptor bound protein 2 0.0122 0.0668 0.0654
Plasmodium falciparum glycogen synthase kinase 3 0.0122 0.067 0.6742
Echinococcus multilocularis raf serine:threonine protein kinase 0.0084 0.0302 0.0367
Entamoeba histolytica cell division protein kinase 2, putative 0.0111 0.0568 0.2616
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0057 0.005 0.0056
Echinococcus multilocularis serine:threonine protein kinase N2 0.0138 0.0823 0.1009
Brugia malayi hypothetical protein 0.0111 0.0566 0.0607
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0158 0.1016 0.4635
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0066 0.013 0.0288
Onchocerca volvulus 0.0122 0.067 0.0986
Echinococcus multilocularis casein kinase I delta 0.006 0.0071 0.0083
Echinococcus granulosus serine threonine protein kinase nrc 0.0152 0.0959 0.0946
Loa Loa (eye worm) hypothetical protein 0.0066 0.013 0.0127
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0101 0.047 0.0456
Echinococcus multilocularis activin receptor type 0.0066 0.013 0.0155
Giardia lamblia Kinase, NEK 0.013 0.0747 0.3275
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0152 0.0959 0.1177
Echinococcus granulosus epidermal growth factor receptor kinase 0.0057 0.005 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Schistosoma mansoni protein kinase 0.0076 0.0229 0.0388
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0094 0.0087
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0063 0.0107 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Onchocerca volvulus 0.0057 0.005 0.0052
Schistosoma mansoni tyrosine kinase 0.0255 0.1946 0.3354
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0205 0.0745
Echinococcus granulosus rho-associated protein kinase 1 0.0333 0.2703 0.2692
Echinococcus granulosus epidermal growth factor receptor 0.0655 0.5794 0.5788
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0057 0.005 0.0078
Plasmodium vivax glycogen synthase kinase 3, putative 0.0122 0.067 0.6985
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0115 0.0604 0.2626
Brugia malayi Variant SH3 domain containing protein 0.0101 0.047 0.0502
Giardia lamblia Kinase, CMGC CDK 0.0111 0.0568 0.2406
Brugia malayi Tensin 0.0064 0.0116 0.0111
Entamoeba histolytica protein kinase, putative 0.0071 0.0182 0.0824
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0357 0.2936 0.3613
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.014 0.0844 0.3897
Echinococcus granulosus casein kinase i 0.006 0.0071 0.0056
Loa Loa (eye worm) STAT protein 0.0064 0.0116 0.0111
Schistosoma mansoni tyrosine kinase 0.0111 0.0566 0.097
Entamoeba histolytica protein kinase, putative 0.0057 0.005 0.0211
Echinococcus multilocularis fibroblast growth factor receptor 4 0.026 0.1999 0.2459
Brugia malayi casein kinase I 0.006 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111
Brugia malayi Fibronectin type III domain containing protein 0.0106 0.0517 0.0554
Echinococcus granulosus tyrosine protein kinase Srms 0.0111 0.0566 0.0552
Echinococcus multilocularis protein kinase c iota type 0.0264 0.2035 0.2503
Echinococcus multilocularis tensin 0.0064 0.0116 0.0138
Echinococcus multilocularis expressed protein 0.0057 0.005 0.0056
Onchocerca volvulus 0.0677 0.6008 0.9023
Brugia malayi Protein kinase domain containing protein 0.0111 0.0566 0.0607
Plasmodium falciparum serine/threonine protein kinase, putative 0.014 0.0844 0.8702
Onchocerca volvulus 0.0111 0.0566 0.0829
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0071 0.0182 0.0184
Entamoeba histolytica unconventional myosin IB 0.0057 0.005 0.0211
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.0517 0.0554
Echinococcus granulosus SH2 domain containing adapter protein F 0.0064 0.0116 0.0101
Trypanosoma cruzi Protein kinase B 0.0158 0.1016 0.4635
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0115 0.0604 0.2656
Brugia malayi SH3 domain containing protein 0.0057 0.005 0.0038
Schistosoma mansoni protein kinase 0.0233 0.1739 0.2995
Plasmodium vivax protein kinase Crk2 0.0111 0.0568 0.5921
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0182 0.0824
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.1693 0.2916
Brugia malayi serine/threonine-protein kinase 6 0.014 0.0844 0.0914
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0083 0.0298 0.1362
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.0985 0.1209
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0071 0.0182 0.0184
Loa Loa (eye worm) hypothetical protein 0.0135 0.0801 0.0867
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0122 0.067 0.2975
Brugia malayi hypothetical protein 0.0106 0.0517 0.0554
Leishmania major protein kinase A catalytic subunit isoform 1 0.0062 0.0094 0.0212
Schistosoma mansoni serine/threonine kinase 0.0085 0.0312 0.0532
Echinococcus multilocularis 0.0187 0.1295 0.1591
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0838 0.7563 0.8322
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0057 0.005 0.0035
Brugia malayi Protein kinase domain containing protein 0.0138 0.0823 0.089
Echinococcus granulosus tyrosine protein kinase ABL1 0.0334 0.2712 0.2701
Loa Loa (eye worm) hypothetical protein 0.0088 0.0342 0.0361
Echinococcus multilocularis serine:threonine protein kinase 3 0.026 0.1996 0.2455
Onchocerca volvulus 0.006 0.0071 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0094 0.0155
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0111 0.0566 0.0692
Echinococcus granulosus nostrin 0.0057 0.005 0.0035
Trypanosoma brucei protein kinase, putative 0.0122 0.067 0.2941
Echinococcus granulosus expressed conserved protein 0.0064 0.0116 0.0101
Echinococcus multilocularis N chimaerin 0.0101 0.047 0.0574
Schistosoma mansoni nephrin 0.0058 0.0055 0.0088
Schistosoma mansoni hypothetical protein 0.0057 0.005 0.0078
Schistosoma mansoni run and tbc1 domain containing 0.0057 0.005 0.0078
Loa Loa (eye worm) hypothetical protein 0.007 0.0173 0.0174
Brugia malayi Myosin tail family protein 0.0057 0.005 0.0038
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0064 0.0116 0.0193
Schistosoma mansoni tyrosine kinase 0.0431 0.364 0.628
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0568 0.2616
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0375 0.1718
Echinococcus multilocularis tyrosine protein kinase HCK 0.0236 0.1766 0.2171
Giardia lamblia Aurora kinase 0.014 0.0844 0.3744
Trypanosoma cruzi casein kinase, putative 0.006 0.0071 0.0104
Schistosoma mansoni tyrosine kinase 0.027 0.2094 0.3609
Giardia lamblia Kinase, AGC PKA 0.0152 0.0959 0.4302
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0058 0.0055 0.004
Loa Loa (eye worm) hypothetical protein 0.0058 0.0055 0.0044
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0133 0.0777 0.0953
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.0375 0.1718
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0568 0.0974
Onchocerca volvulus 0.0057 0.005 0.0052
Echinococcus multilocularis Spectrin alpha actinin 0.0057 0.005 0.0056
Entamoeba histolytica protein kinase, putative 0.014 0.0844 0.3897
Brugia malayi Variant SH3 domain containing protein 0.0122 0.0668 0.072
Echinococcus granulosus protein kinase c epsilon type 0.0176 0.119 0.1176
Echinococcus multilocularis roundabout 2 0.0058 0.0055 0.0063
Schistosoma mansoni tyrosine kinase 0.0431 0.364 0.628
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0176 0.119 0.1295
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0076 0.0229 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0205 0.0347
Brugia malayi p70 ribosomal S6 kinase beta 0.0271 0.2102 0.2301
Loa Loa (eye worm) hypothetical protein 0.0079 0.0262 0.0272
Echinococcus multilocularis titin 0.0054 0.0015 0.0013
Schistosoma mansoni ste20-related kinase 0.0204 0.1461 0.2516
Brugia malayi cytokine inducible SH2-containing protein 5 0.0064 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0094 0.0087
Schistosoma mansoni ephrin receptor 0.0061 0.0085 0.0139
Entamoeba histolytica protein kinase domain containing protein 0.014 0.0844 0.3897
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0144 0.0878 0.0952
Schistosoma mansoni cell adhesion molecule 0.0058 0.0055 0.0088
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0074 0.0205 0.0737
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Echinococcus granulosus calcium activated potassium channel 0.0085 0.0312 0.0298
Entamoeba histolytica protein kinase, putative 0.0138 0.0823 0.3797
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Brugia malayi Protein kinase domain containing protein 0.0111 0.0566 0.0607
Loa Loa (eye worm) TK/EPH protein kinase 0.0135 0.0792 0.0856
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0119 0.0641 0.2953
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0111
Echinococcus multilocularis SHC transforming protein 3 0.0064 0.0116 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.005 0.0038
Schistosoma mansoni protein kinase 0.0066 0.013 0.0217
Schistosoma mansoni atypical protein kinase C 0.027 0.2097 0.3615
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0091 0.0375 0.0396
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0144 0.0878 0.0952
Schistosoma mansoni SH2A 0.0064 0.0116 0.0193
Brugia malayi Protein kinase domain containing protein 0.0997 0.9085 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0801 0.0867
Echinococcus granulosus mitogen activated protein kinase 14 0.0155 0.0985 0.0972
Echinococcus granulosus tyrosine protein kinase shark 0.0111 0.0566 0.0552
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3073 0.3372
Schistosoma mansoni GTPase activating protein 0.0064 0.0116 0.0193
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0064 0.0116 0.0138
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0122 0.067 0.0722
Onchocerca volvulus 0.0111 0.0566 0.0829
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0312 0.0532
Brugia malayi Protein kinase domain containing protein 0.048 0.4112 0.4517
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0205 0.0932
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0055 0.0044
Brugia malayi Protein kinase c protein 2 0.01 0.0457 0.0487
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Entamoeba histolytica serine/threonine protein kinase, putative 0.0274 0.2135 0.989
Schistosoma mansoni protein kinase C mu 0.0144 0.0878 0.151
Brugia malayi Guanylate kinase family protein 0.006 0.0071 0.0061
Onchocerca volvulus 0.0064 0.0116 0.0152
Brugia malayi serine/threonine-protein kinase plk-2 0.0274 0.2135 0.2338
Schistosoma mansoni tensin-related 0.0064 0.0116 0.0193
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0064 0.0116 0.0138
Schistosoma mansoni hypothetical protein 0.0057 0.005 0.0078
Echinococcus multilocularis SH2 motif 0.0064 0.0116 0.0138
Brugia malayi Furin-like cysteine rich region family protein 0.0655 0.5794 0.6372
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0647 0.1111
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0079
Schistosoma mansoni tyrosine kinase 0.0384 0.319 0.5503
Brugia malayi Casein kinase II, alpha chain 0.0091 0.0375 0.0396
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.047 0.0804
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0122 0.0668 0.072
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0138 0.0823 0.0809
Toxoplasma gondii CMGC kinase, CK2 family 0.0091 0.0375 0.1493
Schistosoma mansoni tyrosine kinase 0.0168 0.1118 0.1923
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0077 0.0237 0.0245
Entamoeba histolytica p21-activated kinase 0.0082 0.0286 0.1306
Schistosoma mansoni dynamin-associated protein 0.0057 0.005 0.0078
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0115 0.0604 0.2656
Echinococcus multilocularis Immunoglobulin 0.0092 0.038 0.0464
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.047 0.0804
Schistosoma mansoni serine/threonine-protein kinase 0.0158 0.1016 0.1748
Onchocerca volvulus 0.0057 0.005 0.0052
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0111 0.0568 0.2445
Entamoeba histolytica protein kinase, putative 0.0115 0.0604 0.2781
Trichomonas vaginalis AGC family protein kinase 0.0277 0.2159 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.0151 0.068
Loa Loa (eye worm) hypothetical protein 0.0122 0.0668 0.072
Entamoeba histolytica hypothetical protein 0.0057 0.005 0.0211
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0071 0.0311
Loa Loa (eye worm) SH2 domain-containing protein 0.0064 0.0116 0.0111
Echinococcus multilocularis c src tyrosine kinase 0.0168 0.1118 0.1373
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Echinococcus granulosus suppressor of cytokine signaling 7 0.0064 0.0116 0.0101
Toxoplasma gondii AGC kinase 0.0062 0.0094 0.0111
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0191 0.1333 0.1638
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0064 0.0116 0.0138
Loa Loa (eye worm) hypothetical protein 0.0149 0.0934 0.1013
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0094 0.0111
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0122 0.0668 0.1146
Loa Loa (eye worm) protein-tyrosine kinase 0.0057 0.005 0.0038
Leishmania major casein kinase II, putative 0.0091 0.0375 0.1558
Echinococcus granulosus protein kinase shaggy 0.0122 0.067 0.0656
Trichomonas vaginalis STE family protein kinase 0.0076 0.0229 0.1041
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0057 0.005 0.0035
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.0668 0.1146
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.005 0.0211
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0215 0.0791
Giardia lamblia Kinase, NEK 0.013 0.0747 0.3275
Entamoeba histolytica protein kinase, putative 0.0277 0.2159 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0357 0.2936 0.3613
Plasmodium vivax casein kinase 1, putative 0.006 0.0071 0.0744
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0357 0.2936 0.3613
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0064 0.0116 0.0138
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.0959 0.4362
Echinococcus multilocularis nervana 2 0.0133 0.0777 0.0953
Echinococcus granulosus tyrosine protein kinase Fyn 0.0357 0.2936 0.2925
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0172 0.1152 0.1415
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0111 0.0568 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0047 0.0197
Echinococcus multilocularis cyclin dependent kinase 5 0.0111 0.0568 0.0695
Loa Loa (eye worm) hypothetical protein 0.0115 0.0602 0.0648
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0094 0.0087
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0407 0.3418 0.4207
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0094 0.0212
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0205 0.0745
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.2135 0.989
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0074 0.0205 0.0745
Trichomonas vaginalis AGC family protein kinase 0.014 0.0844 0.3897
Loa Loa (eye worm) hypothetical protein 0.0149 0.0934 0.1013
Echinococcus multilocularis mitogen activated protein kinase 3 0.0074 0.0205 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0823 0.1413
Echinococcus multilocularis serine:threonine protein kinase 0.0106 0.052 0.0635
Brugia malayi Tyrosine-protein kinase abl-1 0.0138 0.0823 0.0891
Loa Loa (eye worm) hypothetical protein 0.0069 0.016 0.016
Echinococcus granulosus endophilin A3 0.0057 0.005 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0111 0.0566 0.0607
Brugia malayi Sex muscle abnormal protein 5 0.0122 0.0668 0.072
Entamoeba histolytica BAR/SH3 domain containing protein 0.0057 0.005 0.0211
Brugia malayi Src substrate cortactin 0.0057 0.005 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0058 0.0055 0.0063
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.012 0.0647 0.0793
Schistosoma mansoni C-fyn 0.0057 0.005 0.0078
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0147 0.0911 0.0987
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0058 0.0055 0.0088
Brugia malayi SH2 domain containing protein 0.0064 0.0116 0.0111
Trypanosoma cruzi casein kinase, delta isoform, putative 0.006 0.0071 0.0104
Brugia malayi protein-tyrosine kinase 0.03 0.2384 0.2611
Echinococcus granulosus activin receptor type 0.0066 0.013 0.0115
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0111 0.0566 0.2607
Entamoeba histolytica protein kinase, putative 0.006 0.0072 0.0313
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0182 0.0824
Brugia malayi Protein kinase domain containing protein 0.0106 0.052 0.0556
Entamoeba histolytica hypothetical protein 0.0063 0.0107 0.0475
Brugia malayi Protein kinase domain containing protein 0.0199 0.1416 0.1545
Loa Loa (eye worm) p53BP2 0.0057 0.005 0.0038
Schistosoma mansoni protein kinase 0.006 0.0071 0.0116
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0076 0.0229 0.0277
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0111

Activities

Activity type Activity value Assay description Source Reference
Max_Activity_Concent (functional) 0.8 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Max_Concentration (binding) 50 uM PubChem BioAssay. Counterscreen to eliminate false positive from thermal shift assay Measured in Biochemical System Using Plate Reader - 2119-07_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0047 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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