Detailed information for compound 1364174

Basic information

Technical information
  • TDR Targets ID: 1364174
  • Name: 1-[(2S)-3-methyl-2-[[(2S)-3-oxo-2-propan-2-yl 2,4-dihydroquinoxaline-1-carbonyl]amino]butan oyl]piperidine-4-carboxylic acid
  • MW: 444.524 | Formula: C23H32N4O5
  • H donors: 3 H acceptors: 5 LogP: 2.37 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@@H](C(=O)N1CCC(CC1)C(=O)O)NC(=O)N1[C@@H](C(C)C)C(=O)Nc2c1cccc2)C
  • InChi: 1S/C23H32N4O5/c1-13(2)18(21(29)26-11-9-15(10-12-26)22(30)31)25-23(32)27-17-8-6-5-7-16(17)24-20(28)19(27)14(3)4/h5-8,13-15,18-19H,9-12H2,1-4H3,(H,24,28)(H,25,32)(H,30,31)/t18-,19-/m0/s1
  • InChiKey: XFDZFGZZWQEHKR-OALUTQOASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2S)-2-[[(2S)-2-isopropyl-3-oxo-2,4-dihydroquinoxaline-1-carbonyl]amino]-3-methyl-butanoyl]piperidine-4-carboxylic acid
  • 1-[(2S)-2-[[[(2S)-2-isopropyl-3-oxo-2,4-dihydroquinoxalin-1-yl]-oxomethyl]amino]-3-methyl-1-oxobutyl]-4-piperidinecarboxylic acid
  • 1-[(2S)-2-[[(2S)-2-isopropyl-3-keto-2,4-dihydroquinoxaline-1-carbonyl]amino]-3-methyl-butanoyl]isonipecotic acid
  • 1-[(2S)-3-methyl-2-[[(2S)-3-oxo-2-propan-2-yl-2,4-dihydroquinoxalin-1-yl]carbonylamino]butanoyl]piperidine-4-carboxylic acid
  • STOCK1N-67476

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0239 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0068 0.0149
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0447 0.1423 0.3689
Brugia malayi AMP-binding enzyme family protein 0.0129 0.0367 0.0961
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0148 0.0429 0.1783
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0159 0.0467 0.3239
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0039 0.0068 0.0417
Onchocerca volvulus 0.0039 0.0068 0.0168
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0042 0.0032
Entamoeba histolytica deoxycytidyl transferase, putative 0.0044 0.0085 0.1233
Echinococcus granulosus bloom syndrome protein 0.0027 0.0029 0.0018
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0101 0.0274 0.0993
Schistosoma mansoni ran 0.0022 0.0013 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0129 0.0367 0.2532
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0039 0.0068 0.0266
Schistosoma mansoni hypothetical protein 0.0033 0.0048 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0083 0.0526
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0028 0.0031 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0081 0.018
Brugia malayi nuclear receptor NHR-88 0.0031 0.0042 0.0081
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0159 0.0467 0.3131
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.0546 0.3801
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0042 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.0367 0.2532
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0083 0.0526
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0239 0.0613
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.0183 0.0461
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0041 0.0075 0.017
Brugia malayi Carboxyl transferase domain containing protein 0.1132 0.3699 1
Brugia malayi RNA, U transporter 1 0.0086 0.0224 0.0575
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0085 0.0543
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0042 0.0081
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0039 0.0068 0.0417
Schistosoma mansoni coup transcription factor 0.0031 0.0042 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0101 0.0377
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0041 0.0075 0.0272
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0044 0.0085 0.0198
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0042 0.0031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0159 0.0398
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0042 0.0031
Onchocerca volvulus 0.0039 0.0068 0.0168
Echinococcus granulosus snurportin 1 0.0323 0.1012 0.1001
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0083 0.0526
Echinococcus granulosus dna polymerase eta 0.0074 0.0183 0.0171
Schistosoma mansoni DNA polymerase eta 0.0074 0.0183 0.0172
Toxoplasma gondii ABC1 family protein 0.0043 0.0083 0.0184
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0083 0.0213 0.0544
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0044 0.0085 0.0075
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0044 0.0085 0.0074
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0083 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0042 0.0081
Onchocerca volvulus 0.0129 0.0367 0.2164
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0049
Brugia malayi Fli-1 protein 0.0251 0.0772 0.2059
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0042 0.0081
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0101 0.0274 0.0264
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0102 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Mycobacterium tuberculosis Conserved protein 0.0043 0.0083 0.0526
Plasmodium vivax acyl-CoA synthetase, putative 0.0097 0.026 0.0941
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0083 0.0526
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0042 0.0032
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0031 0.0156
Echinococcus granulosus Biotin lipoyl attachment 0.0041 0.0075 0.0063
Schistosoma mansoni terminal deoxycytidyl transferase 0.0044 0.0085 0.0075
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0041 0.0075 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0083 0.0184
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0101 0.0274 0.1476
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0191
Plasmodium vivax importin-beta 2, putative 0.003 0.0039 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0239 0.0227
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0044 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0191
Echinococcus multilocularis geminin 0.0185 0.0552 0.054
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0447 0.1423 0.6031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0098 0.0233
Echinococcus multilocularis lamin 0.0084 0.0216 0.0205
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0041 0.0075 0.0267
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0447 0.1423 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.026 0.067
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0029 0.2328
Leishmania major DNA polymerase eta, putative 0.0074 0.0183 0.0445
Entamoeba histolytica acyl-CoA synthetase, putative 0.0129 0.0367 0.5996
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0042 0.0081
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.026 0.1645
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0068 0.0235
Loa Loa (eye worm) hypothetical protein 0.0084 0.0216 0.0553
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1173 0.3836 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0075 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0238 0.1619
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0039 0.0068 0.0266
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0068 0.0417
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0028 0.0031 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0042 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0347 0.1092 0.4616
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0148 0.0429 0.1131
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0041 0.0075 0.0163
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0159 0.0467 0.3239
Onchocerca volvulus 0.0084 0.0216 0.116
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0068 0.0149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0083 0.0073
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0041 0.0075 0.0272
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0164 0.0484 0.1234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0098 0.0233
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0068 0.0144
Leishmania major hypothetical protein, conserved 0.0049 0.0102 0.0234
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0073 0.0061
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0159 0.0467 0.0455
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0191
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0041 0.0075 0.0163
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0041 0.0075 0.0163
Onchocerca volvulus 0.0043 0.0083 0.0271
Schistosoma mansoni hypothetical protein 0.0185 0.0552 0.0542
Leishmania major acetyl-CoA carboxylase, putative 0.1173 0.3836 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0042 0.0081
Brugia malayi Importin beta-1 subunit 0.003 0.0039 0.0072
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0093 0.0219
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0159 0.0467 0.1942
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0148 0.0429 0.042
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0083 0.0191
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0013 0.0045
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0039 0.0068 0.0266
Loa Loa (eye worm) hypothetical protein 0.0138 0.0396 0.1041
Mycobacterium ulcerans hypothetical protein 0.0129 0.0367 0.2413
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0085 1
Schistosoma mansoni ran 0.0022 0.0013 0.0002
Mycobacterium ulcerans acetyl-CoA synthetase 0.0039 0.0068 0.0266
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0028 0.0031 0.0156
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0041 0.0075 0.0065
Schistosoma mansoni acetyl-CoA carboxylase 0.1173 0.3836 0.3829
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.0367 0.0926
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0083 0.0301
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0353 0.0343
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0101 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0042 0.0081
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0129 0.0367 0.2532
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0068 0.0417
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0148 0.0429 0.0418
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0159 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.004 0.0071
Loa Loa (eye worm) RNA binding protein 0.0067 0.0159 0.0398
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1173 0.3836 1
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0101 0.0274 0.1118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0353 0.2316
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0129 0.0367 0.2413
Brugia malayi ecdysteroid receptor 0.0031 0.0042 0.0081
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0041 0.0075 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0042 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0042 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0083 0.0071
Echinococcus granulosus importin subunit beta 1 0.003 0.0039 0.0027
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.02 0.0603 1
Toxoplasma gondii pyruvate carboxylase 0.0447 0.1423 0.3689
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0101 0.0274 0.0684
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0068 0.0144
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0159 0.0467 0.3131
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0148 0.0429 0.1131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0042 0.0031
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0148 0.0429 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0042 0.0081
Trypanosoma brucei unspecified product 0.0294 0.0914 0.2359
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0087 0.0203
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0159 0.0467 0.3239
Echinococcus multilocularis Protein lozenge 0.0061 0.014 0.0128
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0068 0.0144
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0041 0.0075 0.047
Brugia malayi Ets-domain containing protein 0.0083 0.0213 0.0544
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0191
Mycobacterium ulcerans hypothetical protein 0.0183 0.0546 0.3702
Treponema pallidum pyruvate carboxylase subunit B 0.0041 0.0075 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.002 0.1034
Schistosoma mansoni hypothetical protein 0.0047 0.0093 0.0083
Loa Loa (eye worm) hypothetical protein 0.003 0.0039 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0042 0.0031
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0041 0.0075 0.0267
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0029 0.0046
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0447 0.1423 0.1414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0353 0.2316
Entamoeba histolytica acyl-coA synthetase, putative 0.0129 0.0367 0.5996
Echinococcus granulosus lamin dm0 0.0084 0.0216 0.0205
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0849 0.2759 1
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0447 0.1423 0.1414
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0039 0.0068 0.0417
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0484 0.1234
Brugia malayi hypothetical protein 0.0228 0.0697 0.1857
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0159 0.0149
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0159 0.0467 0.1188
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0148 0.0429 0.1091
Mycobacterium tuberculosis Conserved protein 0.0043 0.0083 0.0526
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0085 0.0191
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0041 0.0075 0.0319
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0085 0.0393
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0041 0.0075 0.0065
Loa Loa (eye worm) hypothetical protein 0.0097 0.026 0.067
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0041 0.0075 0.0163
Loa Loa (eye worm) hypothetical protein 0.0129 0.0367 0.0961
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.0367 0.0926
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0042 0.0031
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0031 0.0156
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.1012 0.2711
Brugia malayi AMP-binding enzyme family protein 0.0129 0.0367 0.0961
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0083 0.0301
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0039 0.0068 0.0144
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.0183 0.0445
Loa Loa (eye worm) beta-lactamase 0.0043 0.0083 0.0191
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0083 0.0526
Loa Loa (eye worm) hypothetical protein 0.0071 0.0173 0.0436
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0148 0.0429 0.0418
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0068 0.0149
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0447 0.1423 0.1413
Mycobacterium tuberculosis Conserved protein 0.0043 0.0083 0.0526
Leishmania major carboxylase, putative 0.0447 0.1423 0.3689
Leishmania major hypothetical protein, conserved 0.0043 0.0083 0.0184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0042 0.0031
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0041 0.0075 0.0267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0042 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0042 0.0081
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0042 0.0031
Trichomonas vaginalis esterase, putative 0.0043 0.0083 0.9664
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0102 0.0382
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0239 0.0613
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0083 0.0526
Mycobacterium ulcerans hypothetical protein 0.0043 0.0083 0.0375
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0068 0.7562
Leishmania major importin beta-1 subunit, putative 0.0025 0.002 0.002
Brugia malayi hypothetical protein 0.0049 0.0102 0.0243
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Brugia malayi AMP-binding enzyme family protein 0.0129 0.0367 0.0961
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0353 0.2436
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0697 0.0686
Leishmania major DNA polymerase eta, putative 0.0043 0.0081 0.018
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0697 0.0686
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0353 0.0342
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0041 0.0075 0.0228
Brugia malayi TAR-binding protein 0.0067 0.0159 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0239 0.0227
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0039 0.0068 0.0417
Onchocerca volvulus 0.0084 0.0216 0.116
Echinococcus multilocularis lamin dm0 0.0084 0.0216 0.0205
Echinococcus multilocularis GA binding protein alpha chain 0.0083 0.0213 0.0201
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0042 0.0031
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0041 0.0075 0.017
Schistosoma mansoni gabp alpha 0.0083 0.0213 0.0203
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0042 0.0031
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0046 0.0261
Leishmania major DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0041 0.0075 0.0163
Echinococcus granulosus lamin 0.0084 0.0216 0.0205
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0041 0.0075 0.0228
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Brugia malayi beta-lactamase family protein 0.0043 0.0083 0.0191
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0041 0.0075 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0083 0.9664
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0347 0.1092 0.2824
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0042 0.0032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0129 0.0367 0.5996
Leishmania major carbamoyl-phosphate synthase, putative 0.0101 0.0274 0.0684
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0039 0.0068 0.0149
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0041 0.0075 0.0063
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0039 0.0068 0.0266
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0353 0.0891
Brugia malayi MH2 domain containing protein 0.0234 0.0716 0.1907
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0039 0.0069
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0042 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0042 0.0081
Trichomonas vaginalis importin beta-1, putative 0.0025 0.002 0.1034
Echinococcus granulosus transcription factor Dp 1 0.0086 0.0223 0.0211
Trypanosoma brucei acetyl-CoA carboxylase 0.1173 0.3836 1
Loa Loa (eye worm) RecQ helicase 0.0027 0.0029 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0239 0.0229
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0447 0.1423 1
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0085 0.0191
Loa Loa (eye worm) hypothetical protein 0.0097 0.026 0.067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0353 0.2316
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0353 0.0342
Brugia malayi Disco-interacting protein 2 homolog 0.0028 0.0031 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0042 0.0031
Entamoeba histolytica acetyl-coA carboxylase, putative 0.02 0.0603 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.026 0.067
Brugia malayi nuclear hormone receptor 0.0031 0.0042 0.0081
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0042 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0239 0.0229
Echinococcus multilocularis dna polymerase eta 0.0074 0.0183 0.0171
Schistosoma mansoni ets-related 0.0251 0.0772 0.0762
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Brugia malayi beta-lactamase 0.0043 0.0083 0.0191
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0447 0.1423 1
Echinococcus granulosus dna polymerase kappa 0.0044 0.0085 0.0074
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0159 0.0467 0.1942
Entamoeba histolytica hypothetical protein 0.0025 0.002 0.0128
Echinococcus multilocularis importin subunit beta 1 0.003 0.0039 0.0027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0211 0.0539
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0101 0.0231
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0097 0.026 0.1524
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0041 0.0075 0.0163
Brugia malayi Ets-domain containing protein 0.0083 0.0213 0.0544
Onchocerca volvulus 0.0043 0.0083 0.0271
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0039 0.0068 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0068 0.0149
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0085 0.0191
Echinococcus granulosus geminin 0.0185 0.0552 0.054
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0039 0.0069
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0101 0.0274 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0041 0.0075 0.0319
Trypanosoma brucei unspecified product 0.003 0.004 0.0071
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0102 0.0369
Echinococcus granulosus tar DNA binding protein 0.0067 0.0159 0.0148
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0039 0.0068 0.0417
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0039 0.0068 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0159 0.0149
Schistosoma mansoni hypothetical protein 0.0022 0.0012 0.0001
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0447 0.1423 1
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0447 0.1423 0.3689
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0039 0.0068 0.0417
Brugia malayi steroid hormone receptor 0.0031 0.0042 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0353 0.0343
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0085 0.0543
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0447 0.1423 1
Schistosoma mansoni lozenge 0.0061 0.014 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0042 0.0081
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0013 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.303 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.0367 0.0926
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0484 0.2018
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0159 0.0467 0.3131
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0041 0.0075 0.047
Toxoplasma gondii hypothetical protein 0.0056 0.0125 0.0293
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0068 0.7562
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0048 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0159 0.0149
Echinococcus granulosus GA binding protein alpha chain 0.0083 0.0213 0.0201
Onchocerca volvulus 0.0039 0.0068 0.0168
Loa Loa (eye worm) hypothetical protein 0.0483 0.1541 0.4147
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0129 0.0367 0.2413
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0083 0.0191
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0096
Schistosoma mansoni importin beta-1 0.003 0.0039 0.0029
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0041 0.0075 0.0063
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0039 0.0068 0.0266
Onchocerca volvulus 0.0483 0.1541 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0068 0.0235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0239 0.0227
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0159 0.0467 0.1942
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0083 0.0526
Onchocerca volvulus 0.0047 0.0093 0.034
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0028 0.0031 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0159 0.0149
Schistosoma mansoni hypothetical protein 0.0185 0.0552 0.0542
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0861 0.6027
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0041 0.0075 0.047
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0163
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0041 0.0075 0.0163
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0149
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0149
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0068 0.0144
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0101 0.0274 0.1118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0238 0.1619
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0013 0.0001
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0447 0.1423 1
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0159 0.0467 0.0457
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0085 0.0393
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0238 0.1619
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0159 0.0148
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0159 0.0467 0.1188
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0041 0.0075 0.017
Giardia lamblia DINP protein human, muc B family 0.0044 0.0085 0.1233
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0087 0.0203
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0159 0.0467 0.3131
Mycobacterium ulcerans pyruvate carboxylase 0.0447 0.1423 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0068 0.0235
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0102 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0039 0.0069
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0042 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0085 0.0311
Loa Loa (eye worm) hypothetical protein 0.0041 0.0075 0.017
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0159 0.0467 0.3233
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0159 0.0467 0.1188
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0068 0.0149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0083 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0042 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0102 0.0326
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0073 0.0061
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0068 0.0235
Echinococcus granulosus disco interacting protein 2 0.0028 0.0031 0.0019
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0068 0.0417
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.0183 0.0727
Onchocerca volvulus 0.0039 0.0068 0.0168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0042 0.0031
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0085 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0083 0.0375
Loa Loa (eye worm) hypothetical protein 0.0483 0.1541 0.4147
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0041 0.0075 0.047
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0042 0.0032
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0191
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0159 0.0467 0.2905
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0041 0.0075 0.0063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0243
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0042 0.0081
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0041 0.0075 0.0267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0097 0.026 0.1775
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0716 0.1907
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.0367 0.2413
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0081 0.0294
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0159 0.0467 0.3131
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0039 0.0068 0.0266
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0083 0.0375
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0102 0.0382
Schistosoma mansoni lamin 0.0084 0.0216 0.0206
Echinococcus multilocularis snurportin 1 0.0323 0.1012 0.1001
Trypanosoma cruzi acetyl-CoA carboxylase 0.0726 0.2351 1
Brugia malayi RNA binding protein 0.0067 0.0159 0.0398
Loa Loa (eye worm) oxidoreductase 0.0039 0.0068 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0085 0.0311
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0159 0.0467 0.3131
Plasmodium falciparum acyl-CoA synthetase 0.0097 0.026 0.09
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0148 0.0429 0.1783
Loa Loa (eye worm) fli-1 protein 0.0251 0.0772 0.2059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0075 0.017
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0028 0.0031 0.0156
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0216 0.0553
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Loa Loa (eye worm) hypothetical protein 0.0228 0.0697 0.1857
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0085 0.0311
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0083 0.9664
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0083 0.0375
Loa Loa (eye worm) hypothetical protein 0.0048 0.0098 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0083 0.0526
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0447 0.1423 0.1413
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0039 0.0068 0.0144
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0353 0.0891
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0136 0.0529
Schistosoma mansoni intermediate filament proteins 0.0084 0.0216 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0042 0.0081
Loa Loa (eye worm) runx1 0.0061 0.014 0.0345
Schistosoma mansoni hypothetical protein 0.0323 0.1012 0.1003
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0039 0.0068 0.0933
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0042 0.0081
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0216 0.0553
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1173 0.3836 0.3828
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0148 0.0429 0.706
Onchocerca volvulus 0.0043 0.0083 0.0271
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0042 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0129 0.0367 0.2532
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0159 0.0467 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0085 0.0191
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0129 0.0367 0.2413
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0039 0.0068 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0085 0.0198
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0039 0.0068 0.0417
Chlamydia trachomatis biotin carboxylase 0.0406 0.1286 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1731 0.5688 0.5683
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0028 0.0031 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.0367 0.2413
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0447 0.1423 0.3689
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.002 0.0032
Trypanosoma brucei unspecified product 0.003 0.004 0.0071
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0101 0.0274 0.1748
Mycobacterium ulcerans hypothetical protein 0.0041 0.0075 0.0319
Brugia malayi hypothetical protein 0.0032 0.0044 0.0085
Echinococcus multilocularis Biotin lipoyl attachment 0.0041 0.0075 0.0063
Brugia malayi beta-lactamase family protein 0.0043 0.0083 0.0191
Toxoplasma gondii carbamoylphosphate synthetase 0.0101 0.0274 0.0684
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0028 0.0031 0.0156
Schistosoma mansoni acetyl-CoA synthetase 0.0039 0.0068 0.0057
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0028 0.0031 0.0156
Toxoplasma gondii propionate-CoA ligase 0.0039 0.0068 0.0144
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0041 0.0075 0.0228
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0849 0.2759 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0083 0.9664
Echinococcus granulosus intermediate filament protein 0.0084 0.0216 0.0205
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0159 0.0467 0.3239
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0159 0.0467 0.3239
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0039 0.0068 0.0266
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0447 0.1423 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0239 0.0227
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0029 0.2328
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.004 0.0071
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0083 0.9664
Schistosoma mansoni survival motor neuron protein 0.0047 0.0093 0.0083
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0041 0.0075 0.047
Echinococcus multilocularis disco interacting protein 2 0.0028 0.0031 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0042 0.0031
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0041 0.0075 0.0163
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0041 0.0075 0.0163
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0159 0.0467 0.1188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.002 0.1034
Mycobacterium leprae Probable lipase LipE 0.0043 0.0083 0.0526
Schistosoma mansoni pyruvate carboxylase 0.0447 0.1423 0.1414
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0029 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0039 0.0068 0.0201
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0041 0.0075 0.0267
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0083 0.03
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0031 0.0156
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0018 0.0022
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0042 0.0032
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0041 0.0075 0.0267
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0042 0.0032
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0129 0.0367 0.2413
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.004 0.0071
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0039 0.0068 0.0417
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0068 0.0149
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0041 0.0075 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0042 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0042 0.0032
Plasmodium falciparum importin beta, putative 0.003 0.0039 0.0097
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0447 0.1423 0.6031
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Mycobacterium ulcerans lipase LipD 0.0043 0.0083 0.0375
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0042 0.0031
Echinococcus multilocularis musashi 0.0084 0.0216 0.0205
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0042 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0041 0.0075 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0042 0.0031
Loa Loa (eye worm) hypothetical protein 0.0074 0.0183 0.0461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0149
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0031 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0042 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0098 0.0233
Trypanosoma brucei unspecified product 0.0044 0.0085 0.0191
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0068 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0042 0.0081
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0039 0.0068 0.0417
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.1173 0.3836 0.3828
Plasmodium falciparum carbamoyl phosphate synthetase 0.0101 0.0274 0.0952
Loa Loa (eye worm) hypothetical protein 0.0129 0.0367 0.0961
Brugia malayi hypothetical protein 0.0483 0.1541 0.4147
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0039 0.0068 0.0417
Leishmania major mitochondrial DNA polymerase beta 0.0347 0.1092 0.2824
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.0367 0.2413
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0238 0.1619
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0216 0.0553
Loa Loa (eye worm) hypothetical protein 0.0097 0.026 0.067
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0042 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0042 0.0081
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0716 0.1907
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0041 0.0075 0.0163
Brugia malayi intermediate filament protein 0.0084 0.0216 0.0553
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0042 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0347 0.1092 0.4616
Echinococcus multilocularis transcription factor Dp 1 0.0086 0.0223 0.0211
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0159 0.0398
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0041 0.0075 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0083 0.9664
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0101 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0102 0.0234
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0068 0.0266
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0039 0.0068 0.0144
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1132 0.3699 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0085 0.0191
Schistosoma mansoni microtubule-associated protein tau 0.303 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0085 0.0311
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0129 0.0367 0.0961
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0042 0.0032
Schistosoma mansoni lamin 0.0084 0.0216 0.0206
Plasmodium vivax acetyl-CoA synthetase, putative 0.0039 0.0068 0.0245
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0039 0.0068 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0159 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0042 0.0081
Schistosoma mansoni aspartate carbamoyltransferase 0.0101 0.0274 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0081
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0041 0.0075 0.0065

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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