Detailed information for compound 1378366

Basic information

Technical information
  • TDR Targets ID: 1378366
  • Name: 4-ethylsulfonyl-2-[(6-methyl-2-methylsulfanyl pyrimidin-4-yl)amino]phenol
  • MW: 339.433 | Formula: C14H17N3O3S2
  • H donors: 2 H acceptors: 5 LogP: 2.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc(cc(n1)C)Nc1cc(ccc1O)S(=O)(=O)CC
  • InChi: 1S/C14H17N3O3S2/c1-4-22(19,20)10-5-6-12(18)11(8-10)16-13-7-9(2)15-14(17-13)21-3/h5-8,18H,4H2,1-3H3,(H,15,16,17)
  • InChiKey: LGDULKPAXYPOIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-ethylsulfonyl-2-[(6-methyl-2-methylsulfanyl-pyrimidin-4-yl)amino]phenol
  • 4-ethylsulfonyl-2-[[6-methyl-2-(methylthio)-4-pyrimidinyl]amino]phenol
  • 4-ethylsulfonyl-2-[[6-methyl-2-(methylthio)pyrimidin-4-yl]amino]phenol
  • D278-0486
  • NCGC00117997-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Hypothetical protein 0.0026 0.0064 0.0127
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0238 0.0331
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0026 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0085 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0133
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0096 0.0133
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0416 0.0416
Brugia malayi hypothetical protein 0.0035 0.0094 0.013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0642 0.2199 1
Onchocerca volvulus 0.0036 0.0096 0.0861
Onchocerca volvulus 0.0057 0.0171 0.1782
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0204 0.068 0.0944
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0099 0.0315 0.0437
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0064 0.0055
Mycobacterium leprae Probable lipase LipE 0.0036 0.0096 0.0047
Schistosoma mansoni thyroid hormone receptor 0.0184 0.0612 0.0612
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0099 0.0315 0.1286
Onchocerca volvulus 0.0099 0.0315 0.3536
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Brugia malayi Pre-SET motif family protein 0.0032 0.0082 0.0114
Brugia malayi CHE-14 protein 0.0041 0.0115 0.016
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0026 0.0026
Onchocerca volvulus 0.0099 0.0315 0.3536
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Trypanosoma brucei pantothenate kinase subunit, putative 0.0026 0.0064 0.1356
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Mycobacterium tuberculosis Conserved protein 0.0036 0.0096 0.0102
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0032 0.0044
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.05 0.05
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0094 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0096 0.0275
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0081 0.0113
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Brugia malayi isocitrate dehydrogenase 0.0015 0.0026 0.0036
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.0108
Leishmania major fatty acyl CoA syntetase 1, putative 0.0026 0.0064 0.0058
Trypanosoma brucei fatty acyl CoA synthetase 4 0.0026 0.0064 0.1356
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0085 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0085 0.0085
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0099 0.0315 0.0437
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0085 0.0085
Leishmania major hypothetical protein, unknown function 0.0026 0.0064 0.0058
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.0265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0085 0.0085
Schistosoma mansoni patched 1 0.0041 0.0115 0.0115
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0081 0.0081
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0026 0.0026
Schistosoma mansoni lamin 0.0057 0.0171 0.0171
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0079 0.011
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0026 0.0064 0.0127
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0026 0.0036
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0096 0.0096
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0099 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Toxoplasma gondii propionate-CoA ligase 0.0099 0.0315 0.1515
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0096 0.0102
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0085 0.0085
Schistosoma mansoni acetyl-CoA synthetase 0.0099 0.0315 0.0315
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0099 0.029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0564 0.1929 0.1929
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0316 0.0438
Schistosoma mansoni zinc finger protein 0.0015 0.0026 0.0026
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0081 0.0113
Brugia malayi MH2 domain containing protein 0.0115 0.0373 0.0518
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0026 0.0058
Mycobacterium ulcerans hypothetical protein 0.0036 0.0096 0.0083
Loa Loa (eye worm) hypothetical protein 0.0077 0.0241 0.0335
Loa Loa (eye worm) hypothetical protein 0.005 0.0147 0.0204
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0081
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0064 0.0055
Plasmodium vivax acyl-CoA synthetase, putative 0.0026 0.0064 0.1306
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0509 0.1737 0.1737
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0099 0.0315 0.0418
Echinococcus multilocularis tyrosine protein kinase Abl 0.0083 0.0261 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Brugia malayi intermediate filament protein 0.0057 0.0171 0.0238
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0026 0.0064 0.0127
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0099 0.029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0026 0.0036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0085 0.0085
Schistosoma mansoni tyrosine kinase 0.0201 0.067 0.067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0085 0.0085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0085 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0064 0.0089
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0315 0.0424
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0026 0.0026
Schistosoma mansoni lamin 0.0057 0.0171 0.0171
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0085 0.0085
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0036 0.0036
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0026 0.0064 0.0057
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0026 0.0064 0.0064
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0064 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0085 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Echinococcus granulosus expressed conserved protein 0.009 0.0284 0.0284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0064 0.0055
Echinococcus multilocularis protein dispatched 1 0.0047 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0509 0.1737 0.1737
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0036 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0036 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0096 0.0096
Echinococcus multilocularis microtubule associated protein 2 0.2891 1 1
Echinococcus granulosus zinc finger protein 0.0019 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0026 0.0064 0.0064
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0057
Plasmodium vivax acetyl-CoA synthetase, putative 0.0099 0.0315 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0373 0.0518
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0158 0.022
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0064 0.0055
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0085 0.0085
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0115 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.014 0.014
Schistosoma mansoni nuclear receptor 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.014 0.014
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Echinococcus granulosus geminin 0.0509 0.1737 0.1737
Echinococcus multilocularis geminin 0.0509 0.1737 0.1737
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0099 0.0315 1
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0026 0.0064 0.0064
Brugia malayi Inositol-1 0.0036 0.0099 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Brugia malayi nuclear receptor RXR 0.0015 0.0026 0.0036
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0026 0.0064 0.0055
Giardia lamblia Long chain fatty acid CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0416 0.0529
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0026 0.0036
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0026 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0041 0.0115 0.016
Brugia malayi nuclear receptor NHR-88 0.0032 0.0085 0.0118
Leishmania major hypothetical protein, conserved 0.0026 0.0064 0.0058
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0099 0.0315 0.0418
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.0108
Treponema pallidum fructose-bisphosphate aldolase 0.0642 0.2199 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0096 0.0275
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.0315 0.1286
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0026 0.0036
Brugia malayi Bromodomain containing protein 0.0037 0.0103 0.0142
Echinococcus granulosus lamin dm0 0.0057 0.0171 0.0171
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0026 0.0064 0.1356
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0095 0.0095
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0315 0.0422
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0171 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0095 0.0095
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0026 0.0064 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0171 0.0238
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0309 0.0309
Entamoeba histolytica hypothetical protein 0.0026 0.0064 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0096 0.0275
Echinococcus multilocularis thyroid hormone receptor alpha 0.0184 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0133
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0096 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.2891 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0096 0.0102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0026
Echinococcus multilocularis AMP dependent ligase 0.0026 0.0064 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0078 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0238 0.0238
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0026 0.0064 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Echinococcus granulosus disco interacting protein 2 0.0026 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.014 0.014
Onchocerca volvulus 0.0032 0.0085 0.0724
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0026 0.0036
Echinococcus multilocularis acyl coenzyme A synthetase family 0.0026 0.0064 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0026 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0056 0.0168 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0238 0.0238
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.0882 0.0882
Schistosoma mansoni hypothetical protein 0.004 0.011 0.011
Plasmodium vivax ATP-dependent acyl-CoA synthetase, putative 0.0026 0.0064 0.1306
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0085 0.0118
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0096 0.0102
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0079 0.011
Schistosoma mansoni hypothetical protein 0.004 0.011 0.011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0099 0.029
Echinococcus granulosus long chain fatty acid transport protein 4 0.2012 0.6953 0.6953
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0026 0.0064 0.0057
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0315 0.0422
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0304 0.1238
Schistosoma mansoni hypothetical protein 0.0068 0.0207 0.0207
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0099 0.0315 0.0422
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0026 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0152 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0069 0.0212 0.0295
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0085 0.0085
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0064 0.0198
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0026 0.0064 0.1356
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 0.0026 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0081
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0064 0.1306
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Loa Loa (eye worm) DR-78 0.0015 0.0026 0.0036
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.2012 0.6953 1
Brugia malayi Disco-interacting protein 2 homolog 0.0026 0.0064 0.0089
Loa Loa (eye worm) hypothetical protein 0.0099 0.0316 0.0438
Giardia lamblia Fructose-bisphosphate aldolase 0.0642 0.2199 1
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0843 0.3728
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Echinococcus granulosus intermediate filament protein 0.0057 0.0171 0.0171
Onchocerca volvulus 0.0036 0.0096 0.0861
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium tuberculosis Putative polyketide synthase Pks16 0.0026 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0026 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Trypanosoma brucei fatty acyl CoA synthetase 3 0.0026 0.0064 0.1356
Brugia malayi beta-lactamase family protein 0.0036 0.0096 0.0133
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0026 0.0064 0.0038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0314 0.106 0.1428
Brugia malayi PHD-finger family protein 0.0024 0.0057 0.0079
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Echinococcus granulosus tar DNA binding protein 0.0076 0.0238 0.0238
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0064 0.0055
Mycobacterium ulcerans lipase LipD 0.0036 0.0096 0.0083
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0085 0.0085
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0096 0.0102
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0026 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0064 0.0038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0026 0.0064 0.0057
Brugia malayi cDNA sequence BC018371 0.0026 0.0064 0.0089
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0099 0.0315 0.0422
Onchocerca volvulus 0.0032 0.0082 0.0695
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0081 0.0113
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0057
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0036 0.0354
Schistosoma mansoni ap endonuclease 0.0018 0.0036 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0032 0.0044
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0026 0.0026
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0064 0.0198
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0026 0.0026
Schistosoma mansoni zinc finger protein 0.0015 0.0025 0.0025
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0082 0.0295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0026 0.0064 0.0057
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0026 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0032 0.0044
Giardia lamblia Long chain fatty acid CoA ligase 4 0.0026 0.0064 0.0127
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0026 0.0064 0.0058
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0099 0.0315 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0082 0.0082
Leishmania major long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative 0.0026 0.0064 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0064 0.1306
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Schistosoma mansoni microsomal glutathione s-transferase 0.0564 0.1929 0.1929
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0086 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0085 0.0118
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0081
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0096 0.2461
Brugia malayi TAR-binding protein 0.0076 0.0238 0.0331
Brugia malayi hypothetical protein 0.0262 0.0882 0.1225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0026 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0096 0.0275
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.0265
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0064 0.0198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0064 0.0127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0085 0.0085
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0099 0.0315 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0085 0.0118
Trypanosoma brucei fatty acyl CoA syntetase 1 0.0026 0.0064 0.1356
Echinococcus granulosus long chain fatty acid coenzyme A ligase 4 0.0026 0.0064 0.0064
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0026 0.0064 0.0127
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0031 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1986 0.6862 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0085 0.0724
Echinococcus multilocularis disco interacting protein 2 0.0026 0.0064 0.0064
Brugia malayi nuclear receptor RXR 0.0017 0.0032 0.0044
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0026 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0033 0.0045
Onchocerca volvulus 0.0099 0.0315 0.3536
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0085 0.0085
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0026 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0026 0.0064 0.0038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0096 0.0133
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0026 0.0064 0.0038
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0044
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0026 0.0036
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0315 0.0422
Brugia malayi nuclear receptor NHR-67 0.0015 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0099 0.0099
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0026 0.0036
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0437
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.246 0.8507 0.8507
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.0882 0.0882
Toxoplasma gondii exonuclease III APE 0.0018 0.0036 0.0054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0316 0.0438
Loa Loa (eye worm) AMP-binding enzyme family protein 0.2085 0.7204 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0085 0.0085
Schistosoma mansoni zinc finger protein 0.0019 0.0039 0.0039
Onchocerca volvulus 0.0099 0.0315 0.3536
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0026 0.0064 0.0038
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Loa Loa (eye worm) inositol-1 0.0036 0.0099 0.0138
Trichomonas vaginalis antibiotic synthetase, putative 0.0099 0.0315 0.1286
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0031 0.0031
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0204 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0163
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Brugia malayi nuclear hormone receptor 0.0015 0.0026 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0238 0.0238
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0026 0.0064 0.1356
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0095
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 4 0.0026 0.0064 0.0064
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0096 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0315 0.0424
Trypanosoma brucei acetyl-CoA synthetase, truncated 0.0026 0.0064 0.1356
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0026 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0115 0.0363
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 0.0026 0.0064 0.0038
Loa Loa (eye worm) RNA binding protein 0.0076 0.0238 0.0331
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0064 0.0089
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Schistosoma mansoni hypothetical protein 0.004 0.011 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0315 0.0424
Schistosoma mansoni hypothetical protein 0.0035 0.0094 0.0094
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0099 0.0315 0.0422
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 0.0026 0.0064 0.0038
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0099 0.0315 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0064 0.0089
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0315 0.0369
Onchocerca volvulus 0.0053 0.0158 0.1624
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.2085 0.7204 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0053 0.0158 0.0158
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0081 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0038
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0026 0.0064 0.0127
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.2012 0.6953 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0085 0.0085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0416 0.0529
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.0265
Schistosoma mansoni inositol monophosphatase 0.0036 0.0099 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0064 0.0055
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0026 0.0064 0.0127
Schistosoma mansoni FFA transport protein 0.2012 0.6953 0.6953
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0026 0.0064 0.0064
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0026 0.0064 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0096 0.0103
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0099 0.0315 0.1515
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Leishmania major hypothetical protein, conserved 0.0036 0.0096 0.0104
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0099 0.0315 0.0388
Loa Loa (eye worm) oxidoreductase 0.0099 0.0315 0.0437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0118
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0026 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0373 0.0518
Plasmodium vivax SET domain protein, putative 0.0032 0.0082 0.1946
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0026
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0064 0.0089
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0085 0.0085
Onchocerca volvulus 0.0036 0.0096 0.0861
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0085 0.0724
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0085 0.0118
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0085 0.0085
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0099 0.0315 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0085 0.0118
Schistosoma mansoni hypothetical protein 0.004 0.011 0.011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0036 0.0017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.076 0.1073
Echinococcus multilocularis zinc finger protein 0.0019 0.0039 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0238 0.0331
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0437
Brugia malayi nuclear hormone receptor 0.0032 0.0085 0.0118
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0025
Brugia malayi Bromodomain containing protein 0.0073 0.0227 0.0315
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0099 0.0315 0.0418
Mycobacterium tuberculosis Probable fatty acyl-AMP ligase MbtM 0.0026 0.0064 0.0055
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0085 0.0118
Brugia malayi AMP-binding enzyme family protein 0.2085 0.7204 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0085 0.0118
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0304 0.0422
Plasmodium vivax long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.1306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0026 0.0064 0.0064
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0099 0.0315 0.0418
Echinococcus multilocularis lamin dm0 0.0057 0.0171 0.0171
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0026 0.0064 0.0057
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0315 0.0369
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0085 0.0085
Schistosoma mansoni nuclear receptor 0.0015 0.0026 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.0315 0.0388
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0096 0.0102
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0085 0.0085
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0036 0.041
Brugia malayi beta-lactamase 0.0036 0.0096 0.0133
Loa Loa (eye worm) hypothetical protein 0.0096 0.0304 0.0422
Trichomonas vaginalis AMP dependent ligase, putative 0.0026 0.0064 0.0127
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0096 0.0083
Loa Loa (eye worm) hypothetical protein 0.0262 0.0882 0.1225
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.0416 0.0569
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0026 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0085 0.0118
Toxoplasma gondii hypothetical protein 0.0026 0.0064 0.0198
Brugia malayi ecdysteroid receptor 0.0032 0.0085 0.0118
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0223 0.0288
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0026 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0064 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0085 0.0118
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium tuberculosis Conserved protein 0.0036 0.0096 0.0102
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0099 0.0315 0.0422
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0184 0.0612 0.0612
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0115 0.016
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0026 0.0026
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0099 0.0315 0.0388
Brugia malayi tailless protein 0.0015 0.0026 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0094 0.0094
Echinococcus granulosus acyl coenzyme A synthetase family 0.0026 0.0064 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0096 0.2417
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0099 0.0315 0.0388
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0064 0.0038
Schistosoma mansoni survival motor neuron protein 0.0053 0.0158 0.0158
Trichomonas vaginalis esterase, putative 0.0036 0.0096 0.0275
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Brugia malayi steroid hormone receptor 0.0032 0.0085 0.0118
Brugia malayi Pre-SET motif family protein 0.022 0.0737 0.1023
Echinococcus granulosus GPCR family 2 0.0031 0.0081 0.0081
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0038
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0085 0.0085
Echinococcus multilocularis lamin 0.0057 0.0171 0.0171
Echinococcus granulosus lamin 0.0057 0.0171 0.0171
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0099 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0096 0.0275
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0099 0.029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0026 0.0036
Schistosoma mansoni bromodomain containing protein 0.0062 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0026 0.0026
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0036 0.0051
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0064 0.0055
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0026 0.0002
Leishmania major pantothenate kinase subunit, putative 0.003 0.0077 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0064 0.0038
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0085 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0103 0.0143
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0082 0.0082
Entamoeba histolytica acyl-coA synthetase, putative 0.0099 0.0315 0.1286
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0064 0.0198
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.0315 0.0388
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0416 0.0416
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0026 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0085 0.0118
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0171 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0096 0.0103
Brugia malayi Tyrosine-protein kinase abl-1 0.0083 0.0261 0.0363
Mycobacterium ulcerans beta-lactamase 0.0036 0.0096 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0238 0.0238
Leishmania major fatty acid transporter protein-like protein 0.1986 0.6862 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0085 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0133
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0064 0.0127
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0036 0.0017
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.0265
Trichomonas vaginalis AMP dependent ligase, putative 0.0026 0.0064 0.0127
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0032 0.0032
Brugia malayi hypothetical protein 0.0026 0.0064 0.0089
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0096 0.0102
Brugia malayi hypothetical protein 0.0017 0.0032 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0064 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0026 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0036 0.0036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0026 0.0036
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0099 0.0315 0.0422
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0026 0.0064 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0099 0.0315 0.0424
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0314 0.106 0.1513
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0026 0.0064 0.0055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.0315 0.1286
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0044
Brugia malayi hypothetical protein 0.0015 0.0026 0.0036
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0437
Echinococcus granulosus microsomal glutathione S transferase 3 0.0564 0.1929 0.1929
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0026 0.0058
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0304 0.0304
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0238 0.0238
Echinococcus multilocularis long chain fatty acid transport protein 4 0.2012 0.6953 0.6953
Loa Loa (eye worm) beta-lactamase 0.0036 0.0096 0.0133
Treponema pallidum long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0127
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0315 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0315 0.0388
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0099 0.0315 0.0388
Plasmodium vivax long-chain fatty acid CoA ligase, putative 0.0026 0.0064 0.1306
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.0416 0.0572
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Brugia malayi nuclear receptor NHR-88 0.0015 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0064 0.0038
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0026 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0026 0.0036
Schistosoma mansoni hypothetical protein 0.002 0.0043 0.0043
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0099 0.0315 1
Brugia malayi hypothetical protein 0.0026 0.0064 0.0089
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0085 0.0724
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0099 0.0315 0.0388
Brugia malayi hypothetical protein 0.0015 0.0026 0.0036
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0026 0.0064 0.0064
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.05 0.05
Leishmania major long chain fatty Acyl CoA synthetase, putative 0.0026 0.0064 0.0058
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0068 0.0207 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0085 0.0118
Brugia malayi beta-lactamase family protein 0.0036 0.0096 0.0133
Onchocerca volvulus 0.0251 0.0843 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0096 0.0102
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0026 0.0064 0.0038
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0099 0.0315 0.0422
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0238 0.0331
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0304 0.0304
Trypanosoma brucei Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative 0.0026 0.0064 0.1356
Schistosoma mansoni coup transcription factor 0.0032 0.0085 0.0085
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0175 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0207 0.0288
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0133
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0064 0.0055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0036 0.0354
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0026 0.0064 0.0058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0171 0.0238
Brugia malayi ecdysone receptor 0.0015 0.0026 0.0036
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0099 0.0315 0.0388
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0099 0.0315 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0082 0.0082
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.0416 0.2046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0085 0.0085
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0447 0.0447
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.014 0.014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0032 0.0032
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0085 0.0118
Echinococcus multilocularis expressed conserved protein 0.009 0.0284 0.0284
Echinococcus multilocularis protein patched 0.0041 0.0115 0.0115
Toxoplasma gondii ABC1 family protein 0.0036 0.0096 0.0366
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0064 0.0038
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.2571
Leishmania major acetyl-CoA synthetase, putative 0.0099 0.0315 0.0424
Trypanosoma cruzi pantothenate kinase subunit, putative 0.003 0.0077 0.0075
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0115 0.0115
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0064 0.0089
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0099 0.0383
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0642 0.2199 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0094 0.0094
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0064 0.0038
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0026 0.0026
Leishmania major fatty acyl CoA synthetase 2, putative 0.0026 0.0064 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0085 0.0118
Brugia malayi hypothetical protein 0.0017 0.0032 0.0044
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0064 0.1306
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0032 0.0032
Onchocerca volvulus 0.0057 0.0171 0.1782
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0085 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0044
Echinococcus multilocularis musashi 0.0057 0.0171 0.0171
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0026 0.0064 0.0057
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0036 0.0015
Trichomonas vaginalis antibiotic synthetase, putative 0.0099 0.0315 0.1286
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0085 0.0118
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.0315 0.0388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0315 0.0422
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0085 0.0118
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0737 0.1023
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0064 0.0198
Trypanosoma cruzi AMP-binding enzyme, putative 0.0026 0.0064 0.0057
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0099 0.0315 0.0422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0044
Mycobacterium ulcerans acetyl-CoA synthetase 0.0099 0.0315 0.0388
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.009
Schistosoma mansoni ap endonuclease 0.0018 0.0036 0.0036
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0086 0.0032
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0043 0.0059
Trypanosoma brucei fatty acyl CoA synthetase 2 0.0026 0.0064 0.1356
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0447 0.0447
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0096 0.0096
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0315 0.0369
Schistosoma mansoni intermediate filament proteins 0.0057 0.0171 0.0171
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0085 0.0085
Mycobacterium tuberculosis Conserved protein 0.0036 0.0096 0.0102
Schistosoma mansoni inositol monophosphatase 0.0036 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0085 0.0118
Echinococcus granulosus AMP dependent ligase 0.0026 0.0064 0.0064
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0026 0.0064 0.0058
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0026 0.0064 0.0064
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0085 0.0085
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0099 0.0087
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0026 0.0064 0.0127
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1986 0.6862 1
Brugia malayi RNA binding protein 0.0076 0.0238 0.0331
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0099 0.0315 0.0388
Mycobacterium ulcerans hypothetical protein 0.0099 0.0315 0.0388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.2199 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.0402 0.0558
Toxoplasma gondii MAPEG family protein 0.0564 0.1929 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0437
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0096 0.0096
Echinococcus granulosus tyrosine protein kinase ABL1 0.0204 0.068 0.068
Echinococcus multilocularis GPCR, family 2 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0048 0.014 0.0195
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0175 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0085 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0085 0.0118
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.0416 0.0416
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0316 0.0438
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0315 0.0437
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0437
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0026 0.0064 0.0127
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0099 0.0315 0.1515
Trypanosoma brucei acyl-CoA synthetase, putative 0.0026 0.0064 0.1356
Onchocerca volvulus 0.0026 0.0064 0.0469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0085 0.0118
Trichomonas vaginalis AMP dependent ligase, putative 0.0026 0.0064 0.0127
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0026 0.0064 0.0127
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0026 0.0036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0085 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0064 0.0089
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0314 0.106 0.1466
Onchocerca volvulus 0.0099 0.0315 0.3536
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0416 0.0529
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0099 0.0315 0.0388
Schistosoma mansoni AMP dependent ligase 0.0026 0.0064 0.0064
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0026 0.0026
Brugia malayi conserved hypotetical protein 0.0015 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0036
Leishmania major acetyl-CoA synthetase, putative 0.0099 0.0315 0.0424

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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