TDR Targets

Basic information

Technical information

TDR Targets ID: 1380977
Name: 7-methylsulfonyl-2-(4-phenylphenyl)-2,7-diaza spiro[3.5]nonane
MW: 356.482 | Formula: C20H24N2O2S
H donors: 0 H acceptors: 2 LogP: 3.33 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)N1CCC2(CC1)CN(C2)c1ccc(cc1)c1ccccc1
InChi: 1S/C20H24N2O2S/c1-25(23,24)22-13-11-20(12-14-22)15-21(16-20)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-10H,11-16H2,1H3
InChiKey: XNVYTGZYXUZZEN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-mesyl-2-(4-phenylphenyl)-2,7-diazaspiro[3.5]nonane
NCGC00011369
PCOP-458397

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 10	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	scully CG7113-PA, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Cryptosporidium hominis	scully CG7113-PA	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	hydroxysteroid (17-beta) dehydrogenase 10	252 aa	251 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0028	0.0469	0.0469
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Brugia malayi	Proteasome A-type and B-type family protein	0.0028	0.0469	0.0634
Brugia malayi	cathepsin F-like cysteine proteinase	0.0008	0.0059	0.008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0023	0.0372	0.0372
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0124	0.0124
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0059	0.008
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0028	0.0469	0.0634
Trypanosoma cruzi	cysteine protease, putative	0.0012	0.0145	0.0197
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0028	0.0469	0.0634
Leishmania major	proteasome alpha 2 subunit, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Schistosoma mansoni	survival motor neuron protein	0.0058	0.1095	0.1095
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0028	0.0469	0.0634
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0817	0.1106
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	proteasome subunit alpha type 6	0.0028	0.0469	0.0469
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0028	0.0469	0.0634
Schistosoma mansoni	cathepsin s	0.0008	0.0059	0.0059
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0028	0.0469	0.0634
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0145	0.0145
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0059	0.008
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0366	0.7389	1
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0817	0.0817
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0028	0.0469	0.0469
Loa Loa (eye worm)	ctsf protein	0.0023	0.0372	0.0503
Toxoplasma gondii	peptidase, T1 family protein	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0372	0.0503
Echinococcus granulosus	proteasome prosome macropain	0.0366	0.7389	0.7389
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0028	0.0469	0.0469
Giardia lamblia	20S proteasome alpha subunit 3	0.0028	0.0469	0.0634
Onchocerca volvulus		0.0058	0.1095	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0817	0.0817
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0218	0.0218
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0028	0.0469	0.0634
Leishmania major	proteasome beta-1 subunit, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0023	0.0372	0.0372
Giardia lamblia	20S proteasome alpha subunit 5	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0028	0.0469	0.0469
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Giardia lamblia	20S proteasome alpha subunit 1	0.0028	0.0469	0.0634
Trypanosoma cruzi	cysteine proteinase, putative	0.0012	0.0145	0.0197
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0028	0.0469	0.0634
Trypanosoma cruzi	cysteine proteinase, putative	0.0012	0.0145	0.0197
Plasmodium vivax	vivapain-2	0.0023	0.0372	0.0503
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0081	0.0081
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0145	0.0197
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0028	0.0469	0.0469
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0372	0.0503
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0124	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0372	0.0503
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0028	0.0469	0.0634
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.1225	0.1658
Giardia lamblia	20S proteasome alpha subunit 2	0.0028	0.0469	0.0634
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0124	0.0168
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0081	0.0081
Trypanosoma cruzi	cruzipain precursor, putative	0.0008	0.0059	0.008
Toxoplasma gondii	heat shock protein hslv, putative	0.0028	0.0469	0.0634
Plasmodium vivax	unspecified product	0.0012	0.0145	0.0197
Echinococcus granulosus	proteasome subunit beta type 7	0.0028	0.0469	0.0469
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Echinococcus multilocularis	dnaJ subfamily B	0.0494	1	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0028	0.0469	0.0634
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0028	0.0469	0.0634
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0372	0.0372
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0028	0.0469	0.0634
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0145	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0817	0.1106
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0218	0.0294
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0028	0.0469	0.0634
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0366	0.7389	1
Brugia malayi	proteasome subunit beta type 3	0.0028	0.0469	0.0634
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0028	0.0469	0.0634
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0028	0.0469	0.0634
Trypanosoma brucei	proteasome beta 6 subunit	0.0028	0.0469	0.0634
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0028	0.0469	0.0469
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Giardia lamblia	20S proteasome alpha subunit 6	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0028	0.0469	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0028	0.0469	0.0634
Mycobacterium ulcerans	proteasome PrcA	0.0028	0.0469	0.0634
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0028	0.0469	0.0634
Leishmania major	proteasome beta 7 subunit, putative	0.0028	0.0469	0.0634
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0372	0.0372
Echinococcus multilocularis	cysteine protease	0.0023	0.0372	0.0372
Echinococcus multilocularis	proteasome subunit beta type 7	0.0028	0.0469	0.0469
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0028	0.0469	0.0469
Trypanosoma brucei	proteasome beta 7 subunit	0.0028	0.0469	0.0634
Plasmodium vivax	vivapain-2	0.0023	0.0372	0.0503
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0028	0.0469	0.0634
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0028	0.0469	0.0634
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0081	0.0081
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0121	0.0164
Echinococcus granulosus	proteasome subunit alpha type 2	0.0028	0.0469	0.0469
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0817	0.0817
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0028	0.0469	0.0634
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0028	0.0469	0.0634
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0028	0.0469	0.0634
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0088
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0028	0.0469	0.0634
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0028	0.0469	0.0634
Brugia malayi	proteasome subunit alpha type 3	0.0028	0.0469	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0372	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0218	0.0294
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0028	0.0469	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0023	0.0372	0.0503
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0028	0.0469	0.0634
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0817	0.1106
Echinococcus granulosus	cathepsin L	0.0012	0.0145	0.0145
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0372	0.0503
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0372	0.0372
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0028	0.0469	1
Echinococcus multilocularis	cathepsin L	0.0012	0.0145	0.0145
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0372	0.0503
Toxoplasma gondii	proteasome beta subunit	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0218	0.0294
Giardia lamblia	Proteasome subunit beta type 3	0.0028	0.0469	0.0634
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0028	0.0469	0.0634
Echinococcus multilocularis	cpg binding protein	0.0037	0.0654	0.0654
Loa Loa (eye worm)	PAS-3 protein	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0817	0.1106
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0372	0.0503
Echinococcus granulosus	cysteine protease	0.0012	0.0145	0.0145
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0372	0.0503
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0028	0.0469	0.0634
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0366	0.7389	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0028	0.0469	0.0634
Onchocerca volvulus		0.0035	0.0614	0.5602
Brugia malayi	Proteasome subunit alpha type 1	0.0028	0.0469	0.0634
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.1321	0.1321
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0372	0.0503
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0028	0.0469	0.0469
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0372	0.3397
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0028	0.0469	0.0469
Echinococcus granulosus	proteasome subunit beta t family	0.0028	0.0469	0.0469
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0218	0.0294
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Onchocerca volvulus		0.0023	0.0372	0.3397
Onchocerca volvulus		0.0023	0.0372	0.3397
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0817	0.1106
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0817	0.1106
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0218	0.0294
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0028	0.0469	0.0634
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0028	0.0469	0.0634
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	cysteine protease	0.0023	0.0372	0.0372
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0366	0.7389	1
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0028	0.0469	0.0634
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.1248	0.1688
Toxoplasma gondii	proteasome subunit	0.0028	0.0469	0.0634
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0372	0.3397
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0028	0.0469	0.0634
Plasmodium vivax	vivapain-1	0.0012	0.0145	0.0197
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0028	0.0469	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0817	0.1106
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0145	0.0197
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0028	0.0469	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0012	0.0145	0.0197
Leishmania major	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0028	0.0469	0.0469
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0028	0.0469	0.0469
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0817	0.0817
Leishmania major	proteasome beta 2 subunit, putative	0.0028	0.0469	0.0634
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0817	0.1106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.1321	0.1787
Onchocerca volvulus		0.0023	0.0372	0.3397
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0028	0.0469	0.0469
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0028	0.0469	0.0469
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0015	0.0218	0.0294
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0028	0.0469	0.0469
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0028	0.0469	0.0469
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0028	0.0469	0.0634
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0145	0.0197
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Brugia malayi	Proteasome A-type and B-type family protein	0.0028	0.0469	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0145	0.0197
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0366	0.7389	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.1321	0.1321
Giardia lamblia	Proteasome subunit beta type 2	0.0028	0.0469	0.0634
Leishmania major	proteasome alpha 1 subunit, putative	0.0028	0.0469	0.0634
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0028	0.0469	0.0634
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0028	0.0469	0.0634
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0028	0.0469	0.0634
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0372	0.0503
Echinococcus granulosus	Proteasome subunit alpha beta	0.0028	0.0469	0.0469
Brugia malayi	Proteasome A-type and B-type family protein	0.0366	0.7389	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0817	0.0817
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.1321	0.1787
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.5741	0.5741
Trichomonas vaginalis	helicase, putative	0.0008	0.0065	0.0088
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0028	0.0469	0.0634
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0028	0.0469	0.0469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Loa Loa (eye worm)	fibroinase	0.0023	0.0372	0.0503
Echinococcus granulosus	cathepsin L cysteine protease	0.0012	0.0145	0.0145
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0006	0.0006
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0028	0.0469	0.0634
Onchocerca volvulus		0.0023	0.0372	0.3397
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Schistosoma mansoni	hypothetical protein	0.0058	0.1095	0.1095
Loa Loa (eye worm)	cysteine protease	0.0023	0.0372	0.0503
Plasmodium vivax	unspecified product	0.0008	0.0059	0.008
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0065	0.0088
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0372	0.0372
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0028	0.0469	0.0469
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0028	0.0469	0.0634
Brugia malayi	proteasome subunit alpha type 4	0.0028	0.0469	0.0634
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0088
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0028	0.0469	0.0469
Onchocerca volvulus	Notchless protein homolog	0.0028	0.0469	0.4281
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0028	0.0469	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0023	0.0372	0.0503
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0145	0.0145
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0366	0.7389	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0372	0.0503
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0145	0.0197
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0028	0.0469	0.0469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0145	0.0197
Plasmodium falciparum	proteasome subunit beta type-4	0.0028	0.0469	0.0634
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0366	0.7389	1
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0614	0.083
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0145	0.0145
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0028	0.0469	0.0469
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0145	0.0197
Schistosoma mansoni	hypothetical protein	0.0494	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0028	0.0469	0.0469
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0028	0.0469	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Brugia malayi	cathepsin L-like precursor	0.0015	0.0218	0.0294
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0028	0.0469	0.0634
Brugia malayi	Proteasome A-type and B-type family protein	0.0028	0.0469	0.0634
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0372	0.0372
Trypanosoma cruzi	cruzipain precursor, putative	0.0023	0.0372	0.0503
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0028	0.0469	0.0469
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0028	0.0469	0.0634
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.1321	0.1787
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0817	0.1106
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0028	0.0469	0.0634
Brugia malayi	proteasome subunit alpha type 1	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Leishmania major	cysteine peptidase A (CPA)	0.0023	0.0372	0.0503
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0028	0.0469	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Brugia malayi	20S proteasome alpha5 subunit	0.0028	0.0469	0.0634
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0028	0.0469	0.0634
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0008	0.0059	0.008
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.1321	0.1787
Schistosoma mansoni	cpg binding protein	0.0037	0.0654	0.0654
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0817	0.1106
Brugia malayi	proteasome subunit alpha type 2	0.0028	0.0469	0.0634
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0023	0.0372	0.0503
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0028	0.0469	0.0634
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0817	0.0817
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0372	0.0503
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0028	0.0469	0.0469
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0028	0.0469	0.0634
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0028	0.0469	0.0634
Trypanosoma brucei	proteasome alpha 7 subunit	0.0028	0.0469	0.0634
Echinococcus multilocularis	proteasome subunit beta type 6	0.0028	0.0469	0.0469
Trypanosoma cruzi	20S proteasome subunit	0.0028	0.0469	0.0634
Mycobacterium ulcerans	proteasome PrcB	0.0366	0.7389	1
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0145	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0028	0.0469	0.0634
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.1321	0.1787
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0366	0.7389	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.008
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0088
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0028	0.0469	0.0469
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0145	0.0197
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0366	0.7389	1
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0372	0.0503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Onchocerca volvulus		0.0015	0.0218	0.1986
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0372	0.0503
Echinococcus granulosus	cpg binding protein	0.0037	0.0654	0.0654
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0372	0.0503
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0817	0.0817
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0028	0.0469	0.0469
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1408	0.1408
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0028	0.0469	0.0634
Giardia lamblia	Proteasome subunit beta type 1	0.0028	0.0469	0.0634
Echinococcus granulosus	proteasome subunit beta type 6	0.0028	0.0469	0.0469
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0028	0.0469	0.0634
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0028	0.0469	0.0634
Leishmania major	proteasome beta 5 subunit, putative	0.0366	0.7389	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0817	0.0817
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0366	0.7389	1
Leishmania major	proteasome beta 2 subunit, putative	0.0028	0.0469	0.0634
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Brugia malayi	proteasome subunit beta type 1	0.0028	0.0469	0.0634
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0028	0.0469	0.0634
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0366	0.7389	0.7389
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0028	0.0469	0.0469
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0028	0.0469	0.0469
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0028	0.0469	0.0634
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0028	0.0469	0.0469
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0817	0.1106
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0614	0.083
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0015	0.0218	0.0294
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0372	0.0503
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0028	0.0469	0.0634
Giardia lamblia	20S proteasome alpha subunit 4	0.0028	0.0469	0.0634
Brugia malayi	hypothetical protein	0.0286	0.5741	0.7769
Leishmania major	proteasome beta 3 subunit, putative	0.0028	0.0469	0.0634
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0028	0.0469	0.0634
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0028	0.0469	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0023	0.0372	0.0503
Entamoeba histolytica	cysteine proteinase 2	0.0012	0.0145	0.0197
Leishmania major	proteasome alpha 1 subunit, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	cathepsin l1	0.0023	0.0372	0.0372
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0028	0.0469	0.0634
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.5741	0.5741
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0028	0.0469	0.0469
Brugia malayi	proteasome subunit alpha type 6	0.0028	0.0469	0.0634
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0088
Brugia malayi	proteasome subunit beta type 2	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0028	0.0469	0.0634
Toxoplasma gondii	cathepsin CPL	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0028	0.0469	0.0634
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0028	0.0469	0.0469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0028	0.0469	0.0634
Giardia lamblia	20S proteasome alpha subunit 7	0.0028	0.0469	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.1095	0.1482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0372	0.0503
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0065	0.0088
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0028	0.0469	0.0634
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0028	0.0469	0.0634
Schistosoma mansoni	cpg binding protein	0.0037	0.0654	0.0654
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Brugia malayi	Proteasome subunit alpha type 7-1	0.0028	0.0469	0.0634
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0012	0.0145	0.0197
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0028	0.0469	0.0634
Plasmodium falciparum	proteasome subunit beta type-5	0.0366	0.7389	1
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0028	0.0469	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.008
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0286	0.5741	0.7769
Echinococcus granulosus	cathepsin l1	0.0015	0.0218	0.0218
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0028	0.0469	0.0469
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0028	0.0469	0.0634
Plasmodium vivax	vivapain-3	0.0012	0.0145	0.0197
Onchocerca volvulus		0.0023	0.0372	0.3397
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0372	0.0503
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.1321	0.1321
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0028	0.0469	0.0634
Toxoplasma gondii	proteasome subunit beta type, putative	0.0366	0.7389	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0372	0.0372
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0028	0.0469	0.0469
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0028	0.0469	0.0634
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0028	0.0469	0.0469
Onchocerca volvulus		0.0023	0.0372	0.3397
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0028	0.0469	0.0634
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0145	0.0197
Schistosoma mansoni	cpg binding protein	0.0035	0.0614	0.0614
Entamoeba histolytica	cysteine proteinase 1, putative	0.0012	0.0145	0.0197
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.0218	0.0294
Leishmania major	proteasome alpha 7 subunit, putative	0.0028	0.0469	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.008
Leishmania major	cathepsin L-like protease	0.0023	0.0372	0.0503
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0028	0.0469	0.0634
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0088
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0028	0.0469	0.0634
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0218	0.0294
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0028	0.0469	0.0634
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0028	0.0469	0.0634
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0028	0.0469	0.0634
Onchocerca volvulus	Cathepsin F homolog	0.0023	0.0372	0.3397
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0028	0.0469	0.0634
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Onchocerca volvulus		0.0023	0.0372	0.3397
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0372	0.0503
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0028	0.0469	0.0634
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0372	0.0503
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0028	0.0469	0.0634
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0372	0.0503
Leishmania major	proteasome alpha 3 subunit, putative	0.0028	0.0469	0.0634
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0028	0.0469	0.0634
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0028	0.0469	0.0634
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0366	0.7389	0.7389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0218	0.0294
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0028	0.0469	0.0634
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0028	0.0469	0.0634
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0028	0.0469	0.0469
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0028	0.0469	0.0469
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0008	0.0059	0.008
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0145	0.0197
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0028	0.0469	0.0634
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0028	0.0469	0.0469
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0081	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (ADMET)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1512171

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1380977