Detailed information for compound 1383594

Basic information

Technical information
  • TDR Targets ID: 1383594
  • Name: 6,7-dimethoxy-3-[[4-(4-nitrophenyl)-1,3-thiaz ol-2-yl]amino]-3H-2-benzofuran-1-one
  • MW: 413.404 | Formula: C19H15N3O6S
  • H donors: 1 H acceptors: 4 LogP: 3.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1OC)C(=O)OC2Nc1scc(n1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C19H15N3O6S/c1-26-14-8-7-12-15(16(14)27-2)18(23)28-17(12)21-19-20-13(9-29-19)10-3-5-11(6-4-10)22(24)25/h3-9,17H,1-2H3,(H,20,21)
  • InChiKey: TVANVSVBTIVQQH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 6,7-dimethoxy-3-[[4-(4-nitrophenyl)thiazol-2-yl]amino]-3H-isobenzofuran-1-one
  • 6,7-dimethoxy-3-[[4-(4-nitrophenyl)-2-thiazolyl]amino]-3H-isobenzofuran-1-one
  • 6,7-Dimethoxy-3-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-3H-isobenzofuran-1-one
  • MLS000332779
  • SMR000436175
  • STOCK3S-45330

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0044 0.0069
Echinococcus granulosus regulator of G protein signaling 7 0.0677 0.1561 0.1866
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Schistosoma mansoni hypothetical protein 0.0313 0.0684 0.0684
Echinococcus multilocularis beta adrenergic receptor kinase 0.32 0.7649 0.9141
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0048 0.0044 0.0052
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0677 0.1561 0.1866
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus Pleckstrin y 0.0062 0.0078 0.0094
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0062 0.0078 0.04
Echinococcus granulosus integrin linked protein kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0062 0.0078 0.0094
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0137 0.026 0.1481
Schistosoma mansoni syntrophin 0.0062 0.0078 0.0078
Echinococcus granulosus plexin a4 0.0874 0.2036 0.2434
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Onchocerca volvulus 0.0313 0.0684 0.4013
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0062 0.0078 0.0294
Toxoplasma gondii aurora kinase 0.0076 0.0112 0.913
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Echinococcus multilocularis actin binding protein anillin 0.0062 0.0078 0.0094
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0062 0.0078 0.0094
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1561 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) sema domain-containing protein 0.0313 0.0684 0.0684
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0062 0.0078 0.4601
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Schistosoma mansoni oxysterol-binding protein 1 0.0062 0.0078 0.0078
Echinococcus multilocularis pdz domain containing protein 0.0062 0.0078 0.0094
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Echinococcus granulosus beta-adrenergic receptor kinase 0.32 0.7649 0.9141
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) plexin A 0.0874 0.2036 0.2036
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0062 0.0078 0.0459
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Echinococcus multilocularis regulator of G protein signaling 7 0.0677 0.1561 0.1866
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0313 0.0684 0.0684
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0119 0.0559
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis centaurin alpha, putative 0.0062 0.0078 0.04
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1561 1
Brugia malayi C-terminal src kinase protein 1 0.0048 0.0044 0.0044
Trypanosoma cruzi PH domain containing protein, putative 0.0062 0.0078 0.4601
Leishmania major protein kinase, putative 0.0065 0.0084 0.5399
Schistosoma mansoni fibrocystin l 0.0137 0.026 0.026
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0062 0.0078 0.0294
Echinococcus multilocularis regulator of G protein signaling 7 0.0677 0.1561 0.1866
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Toxoplasma gondii hypothetical protein 0.0062 0.0078 0.4601
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0044 0.0052
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.0044 0.0052
Echinococcus granulosus tyrosine protein kinase HCK 0.0048 0.0044 0.0052
Loa Loa (eye worm) TK/RYK protein kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis regulator of G protein signaling 3 0.0677 0.1561 0.1866
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Schistosoma mansoni z-protein (S1r protein) 0.0677 0.1561 0.1561
Onchocerca volvulus 0.0062 0.0078 0.0459
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0048 0.0044 0.0052
Brugia malayi hypothetical protein 0.0048 0.0044 0.0044
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.0044 0.0052
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0062 0.0078 0.04
Echinococcus granulosus tyrosine protein kinase ABL1 0.0048 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0094 0.0156 0.0156
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Toxoplasma gondii Oxysterol-binding protein 0.0062 0.0078 0.4601
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0062 0.0078 0.04
Loa Loa (eye worm) hypothetical protein 0.0677 0.1561 0.1561
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0677 0.1561 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0044 0.0052
Echinococcus multilocularis calcium dependent secretion activator 1 0.0062 0.0078 0.0094
Echinococcus multilocularis DCC interacting protein 13 beta 0.0062 0.0078 0.0094
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Echinococcus multilocularis muscleblind protein 0.018 0.0364 0.0435
Schistosoma mansoni regulator of G protein signaling 0.0677 0.1561 0.1561
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0048 0.0044 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Schistosoma mansoni protein tyrosine kinase 0.0048 0.0044 0.0044
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Brugia malayi integrin-linked kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0044 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0048 0.0044 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Echinococcus granulosus neuroglian 0.0094 0.0156 0.0187
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0112 0.062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0048 0.0044 0.0052
Loa Loa (eye worm) AUR protein kinase 0.0076 0.0112 0.0112
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0079 0.0119 1
Echinococcus multilocularis transcription factor collier 0.0137 0.026 0.031
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus cytohesin 1 0.0062 0.0078 0.0094
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0062 0.0078 0.0094
Onchocerca volvulus 0.0062 0.0078 0.0459
Entamoeba histolytica hypothetical protein, conserved 0.0062 0.0078 0.0294
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) AUR protein kinase 0.0076 0.0112 0.0112
Echinococcus multilocularis tyrosine kinase 0.0048 0.0044 0.0052
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0079 0.0119 1
Loa Loa (eye worm) Plekhf2 protein 0.0062 0.0078 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.0055 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Entamoeba histolytica ARF GTPase activating protein, putative 0.0062 0.0078 0.0294
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0044 0.0052
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0272 0.0272
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0078 0.0078
Echinococcus granulosus axis inhibition protein axin 0.0677 0.1561 0.1866
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis integrin linked protein kinase 0.0048 0.0044 0.0052
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0048 0.0044 0.0257
Brugia malayi hypothetical protein 0.0677 0.1561 0.1561
Echinococcus multilocularis kinase suppressor of Ras 1 0.0048 0.0044 0.0052
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0062 0.0078 0.4601
Brugia malayi serine/threonine protein kinase 6 0.0076 0.0112 0.0112
Toxoplasma gondii AtPH1 family protein 0.0062 0.0078 0.4601
Brugia malayi Fibronectin type III domain containing protein 0.0099 0.0168 0.0168
Schistosoma mansoni rho gtpase activating protein 0.0062 0.0078 0.0078
Brugia malayi hypothetical protein 0.0099 0.0168 0.0168
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0048 0.0044 0.0257
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0062 0.0078 0.0094
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Schistosoma mansoni hypothetical protein 0.0062 0.0078 0.0078
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0048 0.0044 0.0257
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Plasmodium vivax PH domain containing protein 0.0062 0.0078 0.4601
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0044 0.0069
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3498 0.8367 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Onchocerca volvulus 0.0048 0.0044 0.0257
Echinococcus multilocularis activin receptor type 0.0065 0.0084 0.0101
Echinococcus granulosus tyrosine protein kinase Srms 0.0048 0.0044 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Plasmodium falciparum serine/threonine protein kinase, putative 0.0076 0.0112 0.913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0062 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0065 0.0084 0.0101
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Onchocerca volvulus 0.0048 0.0044 0.0257
Schistosoma mansoni serine/threonine RGC 0.0048 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Echinococcus granulosus transcription factor collier 0.0137 0.026 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0079 0.0119 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0048 0.0044 0.0044
Trichomonas vaginalis protein kinase atn1, putative 0.0048 0.0044 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0062 0.0078 0.0094
Onchocerca volvulus 0.0048 0.0044 0.0257
Schistosoma mansoni axis inhibition protein axin 0.0677 0.1561 0.1561
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0044 0.0052
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Entamoeba histolytica cell surface protease gp63, putative 0.0137 0.026 0.1481
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Toxoplasma gondii protein kinase domain-containing protein 0.0079 0.0119 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0048 0.0044 0.0052
Trichomonas vaginalis STE family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus dynamin 1 0.0062 0.0078 0.0094
Trypanosoma cruzi NIMA-related kinase, putative 0.0079 0.0119 1
Brugia malayi DNA-binding protein LAG-1 0.0137 0.026 0.026
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.0044 0.0052
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0048 0.0044 0.0052
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0044 0.0052
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0062 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.0044 0.0052
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0062 0.0078 0.0078
Brugia malayi MAX-1A 0.0062 0.0078 0.0078
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0062 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase pr2 0.0048 0.0044 0.0052
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0048 0.0044 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1561 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Schistosoma mansoni protein kinase 0.0065 0.0084 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus kinase suppressor of Ras 1 0.0048 0.0044 0.0052
Schistosoma mansoni serine/threonine-protein kinase 0.0079 0.0119 0.0119
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0062 0.0078 0.0459
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3498 0.8367 0.8367
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0044 0.0052
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0062 0.0078 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Schistosoma mansoni plexin 0.0736 0.1705 0.1705
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0142 0.0272 0.0272
Leishmania major protein kinase, putative 0.0079 0.0119 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0076 0.0112 0.0517
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0677 0.1561 0.1561
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0677 0.1561 1
Leishmania major serine/threonine-protein kinase a, putative 0.0079 0.0119 1
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0062 0.0078 0.4601
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi hypothetical protein 0.0313 0.0684 0.0684
Echinococcus granulosus ephrin type A receptor 4 A 0.0048 0.0044 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Brugia malayi hypothetical protein 0.0313 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Leishmania major hypothetical protein, conserved 0.0062 0.0078 0.4601
Loa Loa (eye worm) hypothetical protein 0.0094 0.0156 0.0156
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0062 0.0078 0.0294
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Plasmodium falciparum calcium-dependent protein kinase 7 0.0079 0.0119 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0076 0.0112 0.0134
Loa Loa (eye worm) TK/FAK protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0736 0.1705 0.1705
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi Muscleblind-like protein 0.018 0.0364 0.0364
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Loa Loa (eye worm) serine/threonine protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0112 0.062
Entamoeba histolytica protein kinase domain containing protein 0.0185 0.0375 0.2236
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0048 0.0044 0.0052
Echinococcus granulosus protein kinase 0.0048 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.0112 0.0517
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Onchocerca volvulus 0.0048 0.0044 0.0257
Brugia malayi protein-tyrosine kinase 0.0048 0.0044 0.0044
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) TK/Met protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0677 0.1561 0.1561
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0137 0.026 0.026
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi IPT/TIG domain containing protein 0.0137 0.026 0.026
Schistosoma mansoni protein kinase 0.0065 0.0084 0.0084
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0079 0.0119 0.0662
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3498 0.8367 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0137 0.026 0.1574
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 0.0078 0.4601
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0044 0.0069
Onchocerca volvulus 0.0062 0.0078 0.0459
Brugia malayi Tyrosine-protein kinase abl-1 0.0048 0.0044 0.0044
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Brugia malayi hypothetical protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0094 0.0156 0.0156
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0079 0.0119 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0044 0.0052
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0079 0.0119 1
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0044 0.0052
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0048 0.0044 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Schistosoma mansoni oxysterol-binding protein 1 0.0062 0.0078 0.0078
Echinococcus multilocularis rac serine:threonine kinase 0.0079 0.0119 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus granulosus regulator of G protein signaling 3 0.0677 0.1561 0.1866
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Schistosoma mansoni hypothetical protein 0.0062 0.0078 0.0078
Echinococcus granulosus tyrosine kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.0044 0.0052
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0062 0.0078 0.0094
Brugia malayi Cadps2 protein 0.0062 0.0078 0.0078
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0048 0.0044 0.0069
Echinococcus granulosus twitchin 0.0111 0.0197 0.0235
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.0044 0.0044
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Schistosoma mansoni ephrin receptor 0.0048 0.0044 0.0044
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0062 0.0078 0.0094
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3498 0.8367 0.8367
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0062 0.0078 0.0094
Onchocerca volvulus 0.0048 0.0044 0.0257
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0079 0.0119 0.0559
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0062 0.0074
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0044 0.0069
Echinococcus granulosus exocyst complex component 2 0.0137 0.026 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Echinococcus multilocularis semaphorin 5B 0.0313 0.0684 0.0818
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Trypanosoma cruzi Protein kinase B 0.0079 0.0119 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0677 0.1561 0.1561
Brugia malayi hypothetical protein 0.0048 0.0044 0.0044
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0076 0.0112 0.0134
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0119 0.0559
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis Ras associated and pleckstrin y 0.0062 0.0078 0.0094
Trichomonas vaginalis centaurin beta, putative 0.0062 0.0078 0.04
Echinococcus multilocularis heat shock protein 70 0.0048 0.0044 0.0052
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0044 0.0052
Echinococcus granulosus insulin receptor 0.0048 0.0044 0.0052
Schistosoma mansoni hypothetical protein 0.0062 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0062 0.0078 0.0294
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0044 0.0052
Echinococcus multilocularis neuroglian 0.0094 0.0156 0.0187
Schistosoma mansoni ephrin receptor 0.0053 0.0055 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0084 0.5399
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4175 1 1
Echinococcus multilocularis Rho GTPase activating protein 24 0.0062 0.0078 0.0094
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis insulin receptor 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0062 0.0078 0.0078
Echinococcus multilocularis exocyst complex component 2 0.0137 0.026 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0137 0.026 0.1481
Schistosoma mansoni hypothetical protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Echinococcus multilocularis natriuretic peptide receptor 1 0.0048 0.0044 0.0052
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0044 0.0052
Brugia malayi Plexin repeat family protein 0.0736 0.1705 0.1705
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Brugia malayi Oxysterol binding protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Trypanosoma cruzi PH domain containing protein, putative 0.0062 0.0078 0.4601
Loa Loa (eye worm) hypothetical protein 0.0094 0.0156 0.0156
Leishmania major protein kinase, putative 0.0079 0.0119 1
Echinococcus multilocularis Pleckstrin y 0.0062 0.0078 0.0094
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0062 0.0078 0.4601
Trichomonas vaginalis kinesin light chain, putative 0.0062 0.0078 0.04
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0076 0.0112 0.0517
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.32 0.7649 0.7649
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0079 0.0119 0.0559
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Brugia malayi A-kinase anchor protein 10, precursor 0.0677 0.1561 0.1561
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0048 0.0044 0.0044
Schistosoma mansoni vav2 0.0062 0.0078 0.0078
Onchocerca volvulus Putative zinc finger protein 0.0062 0.0078 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Echinococcus granulosus calcium dependent secretion activator 1 0.0062 0.0078 0.0094
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0677 0.1561 0.1561
Brugia malayi Raf kinase 0.0048 0.0044 0.0044
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0044 0.0052
Echinococcus multilocularis tyrosine protein kinase 0.0048 0.0044 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0062 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0078 0.4601
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Schistosoma mansoni regulator of G protein signaling 0.0677 0.1561 0.1561
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0031 0.0031
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0062 0.0078 0.0294
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Brugia malayi Plekhf2 protein 0.0062 0.0078 0.0078
Brugia malayi Uncoordinated protein 104 0.0062 0.0078 0.0078
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0062 0.0078 0.0294
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0048 0.0044 0.0069
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0023 0.0023
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.0044 0.0052
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.018 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Echinococcus granulosus DCC interacting protein 13 beta 0.0062 0.0078 0.0094
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0044 0.0052
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0084 0.5399
Echinococcus granulosus expressed protein 0.0677 0.1561 0.1866
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Giardia lamblia Aurora kinase 0.0076 0.0112 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Echinococcus granulosus protein tyrosine kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0044 0.0069
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0079 0.0119 1
Echinococcus granulosus oxysterol binding protein 9 0.0062 0.0078 0.0094
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Schistosoma mansoni myotubularin-related protein 0.0062 0.0078 0.0078
Echinococcus granulosus oxysterol binding protein 1 0.0062 0.0078 0.0094
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) AUR protein kinase 0.0076 0.0112 0.0112
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Echinococcus multilocularis raf serine:threonine protein kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0062 0.0078 0.04
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0023 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0044 0.0044
Plasmodium falciparum PH domain-containing protein, putative 0.0062 0.0078 0.4601
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Schistosoma mansoni tyrosine protein kinase 0.0048 0.0044 0.0044
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0079 0.0119 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0094 0.0156 0.0156
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0044 0.0044
Brugia malayi Tyrosine-protein kinase PR2 0.0048 0.0044 0.0044
Brugia malayi serine/threonine-protein kinase 6 0.0076 0.0112 0.0112
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0048 0.0044 0.0052
Onchocerca volvulus 0.0048 0.0044 0.0257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0062 0.0074
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Onchocerca volvulus Tyrosine kinase homolog 0.0048 0.0044 0.0257
Echinococcus granulosus natriuretic peptide receptor 1 0.0048 0.0044 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Brugia malayi Oxysterol-binding protein 0.0062 0.0078 0.0078
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0062 0.0062
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0112 0.062
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 0.0078 0.4601
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis protein kinase 0.0048 0.0044 0.0052
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0033 0.0033
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0313 0.0684 0.0684
Brugia malayi hypothetical protein 0.0677 0.1561 0.1561
Echinococcus granulosus regulator of G protein signaling 7 0.0677 0.1561 0.1866
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Entamoeba histolytica protein kinase, putative 0.0076 0.0112 0.0517
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0062 0.0078 0.04
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Schistosoma mansoni protein kinase 0.0065 0.0084 0.0084
Echinococcus granulosus muscleblind protein 0.018 0.0364 0.0435
Echinococcus granulosus tyrosine protein kinase 0.0048 0.0044 0.0052
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0062 0.0078 0.0094
Schistosoma mansoni plexin 0.0423 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0023 0.0023
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus granulosus activin receptor type 0.0065 0.0084 0.0101
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trypanosoma cruzi PH domain containing protein, putative 0.0062 0.0078 0.4601
Loa Loa (eye worm) RGS-3 protein 0.0677 0.1561 0.1561
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis cytohesin 1 0.0062 0.0078 0.0094
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0137 0.026 0.1574
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0099 0.0168 0.0168
Trichomonas vaginalis TK family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK/DDR protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0119 0.0559
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0677 0.1561 0.1561
Echinococcus multilocularis oxysterol binding protein 9 0.0062 0.0078 0.0094
Echinococcus granulosus Pleckstrin y 0.0062 0.0078 0.0094
Echinococcus multilocularis GRB2 associated binding protein 3 0.0062 0.0078 0.0094
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0062 0.0078 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.32 0.7649 0.7649
Plasmodium falciparum protein kinase, putative 0.0065 0.0084 0.5399
Echinococcus multilocularis c src tyrosine kinase 0.0048 0.0044 0.0052
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0677 0.1561 0.1561
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0119 0.0559
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0677 0.1561 0.1866
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1561 1
Loa Loa (eye worm) sema domain-containing protein 0.0313 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0094 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0423 0.0949 0.0949
Echinococcus multilocularis Oxysterol binding protein 11 0.0062 0.0078 0.0094
Onchocerca volvulus 0.0736 0.1705 1
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Brugia malayi SRC-1 0.0048 0.0044 0.0044
Echinococcus multilocularis Immunoglobulin 0.0094 0.0156 0.0187
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0034 0.0012 0.0069
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0112 0.062
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0137 0.026 0.1574
Onchocerca volvulus outspread protein homolog 0.0062 0.0078 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1561 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0079 0.0119 1
Entamoeba histolytica PH domain containing protein 0.0062 0.0078 0.0294
Echinococcus granulosus serine/threonine protein kinase 0.0079 0.0119 0.0142
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0044 0.0044
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0062 0.0078 0.4601
Brugia malayi hypothetical protein 0.0048 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.0044 0.0052
Echinococcus granulosus Immunoglobulin 0.0094 0.0156 0.0187
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Echinococcus multilocularis axis inhibition protein axin 0.0677 0.1561 0.1866
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Trichomonas vaginalis centaurin/arf, putative 0.0062 0.0078 0.04
Echinococcus multilocularis tyrosine kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Echinococcus multilocularis tyrosine protein kinase pr2 0.0048 0.0044 0.0052
Brugia malayi Protein kinase domain containing protein 0.0295 0.0641 0.0641
Loa Loa (eye worm) TK/CSK protein kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0048 0.0044 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0048 0.0044 0.0044
Brugia malayi hypothetical protein 0.0043 0.0033 0.0033
Echinococcus multilocularis dynamin 1 0.0062 0.0078 0.0094
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.0044 0.0052
Plasmodium falciparum oxysterol-binding protein, putative 0.0062 0.0078 0.4601
Brugia malayi Regulator of G protein signaling domain containing protein 0.0677 0.1561 0.1561
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0079 0.0119 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0033 0.004
Echinococcus multilocularis ephrin type A receptor 4 A 0.0048 0.0044 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0062 0.0078 0.4601
Entamoeba histolytica cysteine surface protein, putative 0.0048 0.0044 0.0069
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Loa Loa (eye worm) hypothetical protein 0.0313 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Echinococcus multilocularis tyrosine protein kinase Abl 0.0048 0.0044 0.0052
Echinococcus multilocularis activated cdc42 kinase 1 0.0048 0.0044 0.0052
Onchocerca volvulus 0.0048 0.0044 0.0257
Entamoeba histolytica protein kinase, putative 0.0076 0.0112 0.0517
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Echinococcus granulosus semaphorin 1A 0.0313 0.0684 0.0818
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0033 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0079 0.0119 0.0119
Entamoeba histolytica hypothetical protein 0.0677 0.1561 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) TK/EPH protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Echinococcus multilocularis transfer RNA-Thr 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase shark 0.0048 0.0044 0.0052
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0048 0.0044 0.0052
Echinococcus multilocularis aurora kinase A 0.0076 0.0112 0.0134
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0079 0.0119 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0048 0.0044 0.0052
Echinococcus granulosus pleckstrin y domain containing family A 0.0062 0.0078 0.0094
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0079 0.0119 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0079 0.0119 1
Onchocerca volvulus 0.0048 0.0044 0.0257
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0048 0.0044 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Entamoeba histolytica receptor protein kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus myotubularin protein 13 0.0062 0.0078 0.0094
Trichomonas vaginalis protein tyrosine kinase, putative 0.0048 0.0044 0.0177
Brugia malayi SH2 domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis expressed protein 0.0677 0.1561 0.1866
Brugia malayi Sema domain containing protein 0.0313 0.0684 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Onchocerca volvulus 0.0048 0.0044 0.0257
Schistosoma mansoni centaurin alpha 0.0062 0.0078 0.0078
Loa Loa (eye worm) rho-GTPase-activating 0.0062 0.0078 0.0078
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Loa Loa (eye worm) hypothetical protein 0.0137 0.026 0.026
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica hypothetical protein 0.0062 0.0078 0.0294
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis FL cytokine receptor 0.0048 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1561 1
Schistosoma mansoni hypothetical protein 0.0423 0.0949 0.0949
Trypanosoma brucei protein kinase, putative 0.0079 0.0119 1
Trypanosoma cruzi PH domain containing protein, putative 0.0062 0.0078 0.4601
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0044 0.0052
Brugia malayi Probable exocyst complex component Sec5 0.0137 0.026 0.026
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Entamoeba histolytica ankyrin repeat protein 0.0048 0.0044 0.0069
Loa Loa (eye worm) SRC-1 0.0048 0.0044 0.0044
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0048 0.0044 0.0257
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0079 0.0119 1
Schistosoma mansoni zinc finger protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0044 0.0052
Echinococcus multilocularis Regulator of G protein signaling 20 0.0677 0.1561 0.1866
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Echinococcus granulosus G protein coupled receptor kinase 1 0.2523 0.6016 0.719
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Schistosoma mansoni goodpasture antigen-binding protein 0.0062 0.0078 0.0078
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0062 0.0078 0.0094
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0062 0.0078 0.0094
Echinococcus granulosus tyrosine protein kinase Lyn 0.0065 0.0084 0.0101
Echinococcus granulosus beta 1 syntrophin 0.0062 0.0078 0.0094
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0048 0.0044 0.0052
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0062 0.0078 0.0078
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Schistosoma mansoni serine/threonine-protein kinase 0.0079 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Echinococcus granulosus Pleckstrin y 0.0062 0.0078 0.0094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0062 0.0062
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0048 0.0044 0.0069
Brugia malayi Sema domain containing protein 0.0313 0.0684 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0177
Echinococcus multilocularis Pleckstrin y 0.0062 0.0078 0.0094
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0048 0.0044 0.0044
Brugia malayi probable spectrin beta chain 0.0062 0.0078 0.0078
Echinococcus multilocularis pleckstrin y domain containing family A 0.0062 0.0078 0.0094
Echinococcus multilocularis hypothetical protein 0.0313 0.0684 0.0818
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0062 0.0078 0.0094
Echinococcus granulosus axis inhibition protein axin 0.0677 0.1561 0.1866
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Entamoeba histolytica tyrosin kinase, putative 0.0185 0.0375 0.2236
Schistosoma mansoni hypothetical protein 0.0062 0.0078 0.0078
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0079 0.0119 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Echinococcus multilocularis regulator of G protein signaling 3 0.0677 0.1561 0.1866
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0079 0.0119 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0044 0.0044
Trypanosoma cruzi NIMA-related kinase, putative 0.0079 0.0119 1
Onchocerca volvulus 0.0048 0.0044 0.0257
Echinococcus multilocularis beta 1 syntrophin 0.0062 0.0078 0.0094
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0062 0.0078 0.0078
Brugia malayi Regulator of G protein signaling domain containing protein 0.0677 0.1561 0.1561
Echinococcus granulosus tyrosine kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis alpha chimerin, putative 0.0062 0.0078 0.04
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0048 0.0044 0.0052
Echinococcus granulosus Rho GTPase activating protein 24 0.0062 0.0078 0.0094
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus multilocularis protein tyrosine kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Echinococcus multilocularis roundabout 2 0.0099 0.0168 0.0201
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica hypothetical protein 0.0677 0.1561 1
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Loa Loa (eye worm) hypothetical protein 0.0677 0.1561 0.1561
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi regulator of G-protein signaling rgs-7 0.0677 0.1561 0.1561
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Schistosoma mansoni hypothetical protein 0.0313 0.0684 0.0684
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0023 0.0027
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus pdz domain containing protein 0.0062 0.0078 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0119 0.0559
Schistosoma mansoni hypothetical protein 0.0137 0.026 0.026
Brugia malayi plexin A 0.0874 0.2036 0.2036
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0062 0.0078 0.04
Brugia malayi PXA domain containing protein 0.0677 0.1561 0.1561
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trypanosoma cruzi hypothetical protein 0.0062 0.0078 0.4601
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Loa Loa (eye worm) AGC/AKT protein kinase 0.0079 0.0119 0.0119
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0044 0.0052
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0062 0.0078 0.4601
Trichomonas vaginalis centaurin gamma, putative 0.0062 0.0078 0.04
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0062 0.0078 0.0078
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Schistosoma mansoni axis inhibition protein axin 0.0677 0.1561 0.1561
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase , putative 0.0076 0.0112 0.0517
Echinococcus multilocularis oxysterol binding protein 1 0.0062 0.0078 0.0094
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.0099 0.0168 0.0168
Trypanosoma brucei aurora B kinase 0.0076 0.0112 0.913
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0062 0.0078 0.0459
Loa Loa (eye worm) TK/EGFR protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0094 0.0156 0.0156
Schistosoma mansoni dynamin 0.0062 0.0078 0.0078
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0094 0.0156 0.0187
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.0044 0.0052
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0062 0.0078 0.0094
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0065 0.0084 0.5399
Schistosoma mansoni zinc finger protein 0.0062 0.0078 0.0078
Onchocerca volvulus 0.0048 0.0044 0.0257
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0048 0.0044 0.0177
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0084 0.5399
Echinococcus multilocularis muscleblind protein 1 0.018 0.0364 0.0435
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) PH domain-containing protein 0.0062 0.0078 0.0078
Schistosoma mansoni cell adhesion molecule 0.0099 0.0168 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0062 0.0074
Echinococcus multilocularis Pleckstrin y 0.0062 0.0078 0.0094
Schistosoma mansoni regulator of G protein signaling 0.0677 0.1561 0.1561
Entamoeba histolytica ankyrin repeat protein 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0044 0.0069
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Schistosoma mansoni vesicular amine transporter 0.0097 0.0162 0.0162
Brugia malayi ephrin receptor 1 precursor 0.0048 0.0044 0.0044
Echinococcus granulosus GRB2 associated binding protein 3 0.0062 0.0078 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.32 0.7649 0.7649
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0079 0.0119 0.0662
Brugia malayi Cytohesin 3 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0677 0.1561 0.1561
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0062 0.0078 0.0078
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0048 0.0044 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica PH domain containing protein 0.0062 0.0078 0.0294
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.0055 0.0066
Brugia malayi regulator of G-protein signaling egl-10 0.0677 0.1561 0.1561
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Echinococcus multilocularis regulator of G protein signaling 0.0677 0.1561 0.1866
Toxoplasma gondii hypothetical protein 0.0062 0.0078 0.4601
Trypanosoma brucei protein kinase, putative 0.0065 0.0084 0.5399
Brugia malayi SH2 domain containing protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) PXA domain-containing protein 0.0677 0.1561 0.1561
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0065 0.0084 0.0101
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0076 0.0112 0.0517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0062 0.0062
Echinococcus granulosus aurora kinase A 0.0076 0.0112 0.0134
Toxoplasma gondii phosphatidylinositol transfer protein 0.0062 0.0078 0.4601
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0062 0.0078 0.0094
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus tyrosine protein kinase shark 0.0048 0.0044 0.0052
Echinococcus multilocularis axis inhibition protein axin 0.0677 0.1561 0.1866
Echinococcus granulosus Regulator of G protein signaling 20 0.0677 0.1561 0.1866
Loa Loa (eye worm) hypothetical protein 0.0313 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0677 0.1561 0.1561
Echinococcus multilocularis tyrosine protein kinase HCK 0.0048 0.0044 0.0052
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.0044 0.0052
Brugia malayi serine/threonine kinase 12 0.0076 0.0112 0.0112
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0094 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0313 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0218 0.0454 0.0454
Schistosoma mansoni regulator of G protein signaling 0.0677 0.1561 0.1561
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2523 0.6016 0.719
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0044 0.0052
Entamoeba histolytica hypothetical protein 0.0137 0.026 0.1481
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0137 0.026 0.1574
Entamoeba histolytica p21-activated kinase 0.0079 0.0119 0.0559
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Echinococcus granulosus raf serine:threonine protein kinase 0.0048 0.0044 0.0052
Loa Loa (eye worm) protein kinase domain-containing protein 0.0048 0.0044 0.0044
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0076 0.0112 0.913
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Brugia malayi PH domain containing protein 0.0062 0.0078 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.4175 1 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0119 0.0559
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Leishmania major protein kinase, putative 0.0076 0.0112 0.913
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus granulosus Oxysterol binding protein 11 0.0062 0.0078 0.0094
Echinococcus multilocularis oxysterol binding protein 3 0.0062 0.0078 0.0094
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0044 0.0052
Brugia malayi Furin-like cysteine rich region family protein 0.0048 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0137 0.026 0.026
Entamoeba histolytica protein kinase, putative 0.0079 0.0119 0.0559
Loa Loa (eye worm) TK/ACK protein kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0044 0.0069
Brugia malayi PXA domain containing protein 0.0677 0.1561 0.1561
Onchocerca volvulus 0.0062 0.0078 0.0459
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0044 0.0052
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0044 0.0177
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0094 0.0156 0.0187
Schistosoma mansoni nephrin 0.0099 0.0168 0.0168
Schistosoma mansoni protein kinase 0.0076 0.0112 0.0112
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0079 0.0119 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0062 0.0078 0.0294
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0062 0.0078 0.0078
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0062 0.0078 0.0094
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Trichomonas vaginalis hypothetical protein 0.0062 0.0078 0.04
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus c src tyrosine kinase 0.0048 0.0044 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0137 0.026 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.026 0.1574
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.018 0.0364 0.0364
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.0044 0.0044
Schistosoma mansoni regulator of G protein signaling 0.0677 0.1561 0.1561
Entamoeba histolytica hypothetical protein 0.0137 0.026 0.1481
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Schistosoma mansoni semaphorin 5-related 0.0313 0.0684 0.0684
Trichomonas vaginalis protein transport protein sec7, putative 0.0062 0.0078 0.04
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0044 0.0069
Entamoeba histolytica receptor protein kinase, putative 0.0048 0.0044 0.0069
Brugia malayi Syntrophin-1 0.0062 0.0078 0.0078
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Schistosoma mansoni goodpasture antigen-binding protein 0.0062 0.0078 0.0078
Brugia malayi TBC domain containing protein 0.0062 0.0078 0.0078
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0062 0.0078 0.0294
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Echinococcus multilocularis protein KINase family member (kin 25) 0.0048 0.0044 0.0052
Trichomonas vaginalis centaurin/arf, putative 0.0062 0.0078 0.04
Echinococcus multilocularis myotubularin protein 13 0.0062 0.0078 0.0094
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0062 0.0078 0.0094
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Onchocerca volvulus Protein melted homolog 0.0062 0.0078 0.0459
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.0099 0.0168 0.0168
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus granulosus tyrosine kinase 0.0048 0.0044 0.0052
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) TK/ABL protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Loa Loa (eye worm) TK protein kinase 0.0048 0.0044 0.0044
Trypanosoma brucei PH domain containing protein, putative 0.0062 0.0078 0.4601
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0112 0.0112
Trypanosoma cruzi aurora B kinase, putative 0.0076 0.0112 0.913
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0048 0.0044 0.0257
Schistosoma mansoni dynamin 0.0062 0.0078 0.0078
Trichomonas vaginalis protein transport protein sec7, putative 0.0062 0.0078 0.04
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Loa Loa (eye worm) cytohesin 3 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Leishmania major hypothetical protein, conserved 0.0062 0.0078 0.4601
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Brugia malayi Dynamin 0.0062 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0313 0.0684 0.0684
Schistosoma mansoni growth factor receptor-bound protein 0.0062 0.0078 0.0078
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0044 0.0069
Brugia malayi Dynamin 0.0062 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Entamoeba histolytica PH domain containing protein 0.0062 0.0078 0.0294
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase, putative 0.0048 0.0044 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0062 0.0062
Echinococcus multilocularis plexin a4 0.0874 0.2036 0.2434
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0048 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0079 0.0119 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0044 0.0052
Brugia malayi bone morphogenetic protein type 1 receptor 0.0048 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Onchocerca volvulus 0.0062 0.0078 0.0459
Loa Loa (eye worm) syntrophin-1 0.0062 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0044 0.0044
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Brugia malayi Pleckstrin Homology Domain 0.0062 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Echinococcus multilocularis Immunoglobulin 0.0094 0.0156 0.0187
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0078 0.04
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0044 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0079 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0043 0.0033 0.0033
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0119 0.0662
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0044 0.0069
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Entamoeba histolytica hypothetical protein 0.0062 0.0078 0.0294
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3498 0.8367 0.8367
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0044 0.0177
Echinococcus multilocularis protein kinase 0.0048 0.0044 0.0052
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0044 0.0069
Loa Loa (eye worm) TK/ALK protein kinase 0.0295 0.0641 0.0641
Echinococcus granulosus oxysterol binding protein 3 0.0062 0.0078 0.0094
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0084 0.0334
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Loa Loa (eye worm) oxysterol binding protein 0.0062 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0048 0.0044 0.0069
Leishmania major folate/biopterin transporter, putative 0.0079 0.0119 1
Echinococcus granulosus regulator of G protein signaling 3 0.0677 0.1561 0.1866
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Onchocerca volvulus 0.0062 0.0078 0.0459
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0062 0.0078 0.0078
Echinococcus granulosus semaphorin 5B 0.0313 0.0684 0.0818
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0137 0.026 0.026
Echinococcus granulosus roundabout 2 0.0099 0.0168 0.0201
Loa Loa (eye worm) uncoordinated protein 104 0.0062 0.0078 0.0078
Echinococcus granulosus fibroblast growth factor receptor 4 0.0048 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Echinococcus granulosus defective proboscis extension response 0.0094 0.0156 0.0187
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0044 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0044 0.0044
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0044 0.0052
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.0044 0.0044

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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