TDR Targets

Basic information

Technical information

TDR Targets ID: 1385461
Name: N-[2-(benzoyl)phenyl]-2-methylsulfanyl-4-(tri fluoromethyl)pyrimidine-5-carboxamide
MW: 417.404 | Formula: C20H14F3N3O2S
H donors: 1 H acceptors: 4 LogP: 4.7 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ncc(c(n1)C(F)(F)F)C(=O)Nc1ccccc1C(=O)c1ccccc1
InChi: 1S/C20H14F3N3O2S/c1-29-19-24-11-14(17(26-19)20(21,22)23)18(28)25-15-10-6-5-9-13(15)16(27)12-7-3-2-4-8-12/h2-11H,1H3,(H,25,28)
InChiKey: YZEQEHBKMPIRSE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(methylthio)-N-[2-(oxo-phenylmethyl)phenyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide
N-[2-(benzoyl)phenyl]-2-(methylthio)-4-(trifluoromethyl)pyrimidine-5-carboxamide
2-methylsulfanyl-N-(2-phenylcarbonylphenyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
E727-0663
NCGC00124516-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0061	0.0037	0.0039
Schistosoma mansoni	syntrophin	0.0088	0.0083	0.0072
Schistosoma mansoni	dynamin	0.0088	0.0083	0.0072
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0.0077	0.4607
Schistosoma mansoni	dynamin	0.0088	0.0083	0.0072
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0111	0.0123	1
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus multilocularis	hypothetical protein	0.0409	0.0629	0.0746
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0061	0.0037	0.0039
Schistosoma mansoni	serine/threonine RGC	0.0061	0.0037	0.0026
Brugia malayi	SH2 domain containing protein	0.0061	0.0037	0.0033
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0061	0.0037	0.0039
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0.0077	0.4607
Onchocerca volvulus		0.0979	0.1597	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0061	0.0037	0.0033
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0088	0.0083	0.0094
Brugia malayi	Cadps2 protein	0.0088	0.0083	0.0079
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0111	0.0123	1
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Brugia malayi	hypothetical protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Loa Loa (eye worm)	serine/threonine protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0061	0.0037	0.0039
Echinococcus granulosus	natriuretic peptide receptor 1	0.0061	0.0037	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Echinococcus multilocularis	activated cdc42 kinase 1	0.0061	0.0037	0.0039
Echinococcus granulosus	cytohesin 1	0.0088	0.0083	0.0094
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0088	0.0083	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus granulosus	oxysterol binding protein 9	0.0088	0.0083	0.0094
Echinococcus granulosus	oxysterol binding protein 1	0.0088	0.0083	0.0094
Trichomonas vaginalis	protein kinase atn1, putative	0.0061	0.0037	0.0239
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Brugia malayi	Furin-like cysteine rich region family protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0111	0.0123	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0111	0.0123	0.0141
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Leishmania major	protein kinase, putative	0.0111	0.0123	1
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0088	0.0083	0.0094
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0061	0.0037	0.0039
Loa Loa (eye worm)	sema domain-containing protein	0.0409	0.0629	0.0624
Echinococcus granulosus	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Echinococcus multilocularis	beta 1 syntrophin	0.0088	0.0083	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0088	0.0083	0.0094
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Brugia malayi	Plexin repeat family protein	0.0979	0.1597	0.1593
Brugia malayi	Plekhf2 protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus granulosus	beta 1 syntrophin	0.0088	0.0083	0.0094
Echinococcus granulosus	axis inhibition protein axin	0.0961	0.1566	0.1867
Echinococcus granulosus	twitchin	0.0139	0.017	0.0198
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0111	0.0123	1
Brugia malayi	integrin-linked kinase	0.0061	0.0037	0.0033
Leishmania major	protein kinase, putative	0.0111	0.0123	1
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0088	0.0083	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Entamoeba histolytica	tyrosin kinase, putative	0.024	0.0342	0.1993
Trichomonas vaginalis	STE family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0083	0.0301
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Echinococcus granulosus	dynamin 1	0.0088	0.0083	0.0094
Entamoeba histolytica	hypothetical protein	0.0088	0.0083	0.0301
Brugia malayi	DNA-binding protein LAG-1	0.0179	0.0238	0.0234
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0084	0.0077	0.4607
Brugia malayi	hypothetical protein	0.0961	0.1566	0.1562
Loa Loa (eye worm)	TK/DDR protein kinase	0.0061	0.0037	0.0033
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0409	0.0629	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Brugia malayi	Dynamin	0.0088	0.0083	0.0079
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0061	0.0037	0.0033
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0088	0.0083	0.0301
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0061	0.0037	0.0239
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0061	0.0037	0.0039
Brugia malayi	C-terminal src kinase protein 1	0.0061	0.0037	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0061	0.0037	0.0239
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0083	0.5393
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	RGS-3 protein	0.0961	0.1566	0.1562
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	Immunoglobulin	0.0116	0.0131	0.0151
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Entamoeba histolytica	cell surface protease gp63, putative	0.0179	0.0238	0.1313
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0123	0.0557
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0061	0.0037	0.0033
Echinococcus multilocularis	transcription factor collier	0.0179	0.0238	0.0279
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Schistosoma mansoni	hypothetical protein	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0061	0.0037	0.0039
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0111	0.0123	1
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	Protein kinase domain containing protein	0.0313	0.0465	0.046
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0066	0.0046	0.005
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Brugia malayi	IPT/TIG domain containing protein	0.0179	0.0238	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Echinococcus multilocularis	beta adrenergic receptor kinase	0.454	0.7649	0.9141
Schistosoma mansoni	goodpasture antigen-binding protein	0.0088	0.0083	0.0072
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0088	0.0083	0.0079
Entamoeba histolytica	hypothetical protein	0.0961	0.1566	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0061	0.0037	0.0033
Schistosoma mansoni	ephrin receptor	0.0066	0.0046	0.0035
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0139	0.0135
Echinococcus multilocularis	activin receptor type	0.0084	0.0077	0.0086
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0061	0.0037	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0037	0.0026
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0088	0.0083	0.5393
Loa Loa (eye worm)	cytohesin 3	0.0088	0.0083	0.0079
Echinococcus granulosus	Oxysterol binding protein 11	0.0088	0.0083	0.0094
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0088	0.0083	0.0094
Echinococcus granulosus	Rho GTPase activating protein 24	0.0088	0.0083	0.0094
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0111	0.0123	0.0783
Echinococcus granulosus	semaphorin 1A	0.0409	0.0629	0.0746
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0061	0.0037	0.0239
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Echinococcus granulosus	oxysterol binding protein 3	0.0088	0.0083	0.0094
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0088	0.0083	0.0094
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	protein kinase	0.0061	0.0037	0.0039
Brugia malayi	Sema domain containing protein	0.0409	0.0629	0.0624
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0088	0.0083	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	pleckstrin y domain containing family A	0.0088	0.0083	0.0094
Schistosoma mansoni	protein kinase	0.0084	0.0077	0.0066
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0088	0.0083	0.5393
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Brugia malayi	Sema domain containing protein	0.0409	0.0629	0.0624
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0088	0.0083	0.5393
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0961	0.1566	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Echinococcus multilocularis	transfer RNA-Thr	0.0061	0.0037	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0961	0.1566	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4963	0.8368	0.8367
Trypanosoma cruzi	Protein kinase B	0.0111	0.0123	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0111	0.0123	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0083	0.0301
Loa Loa (eye worm)	PXA domain-containing protein	0.0961	0.1566	0.1562
Schistosoma mansoni	axis inhibition protein axin	0.0961	0.1566	0.1556
Echinococcus multilocularis	actin binding protein anillin	0.0088	0.0083	0.0094
Schistosoma mansoni	hypothetical protein	0.0409	0.0629	0.0618
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0088	0.0083	0.0094
Echinococcus multilocularis	oxysterol binding protein 9	0.0088	0.0083	0.0094
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0238	0.0234
Echinococcus multilocularis	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Echinococcus granulosus	tyrosine protein kinase pr2	0.0061	0.0037	0.0039
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0961	0.1566	0.1562
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	axis inhibition protein axin	0.0961	0.1566	0.1556
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0084	0.0077	0.0086
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0116	0.0131	0.012
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0961	0.1566	0.1556
Toxoplasma gondii	hypothetical protein	0.0088	0.0083	0.5393
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0238	0.0234
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0111	0.0123	1
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0111	0.0123	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0961	0.1566	0.1867
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Leishmania major	protein kinase, putative	0.0084	0.0077	0.4607
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0088	0.0083	0.5393
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0061	0.0037	0.0039
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0061	0.0037	0.0033
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0061	0.0037	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus granulosus	semaphorin 5B	0.0409	0.0629	0.0746
Brugia malayi	SRC-1	0.0061	0.0037	0.0033
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4963	0.8368	1
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	tyrosine protein kinase shark	0.0061	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Brugia malayi	protein-tyrosine kinase	0.0061	0.0037	0.0033
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0083	0.5393
Schistosoma mansoni	oxysterol-binding protein 1	0.0088	0.0083	0.0072
Trichomonas vaginalis	centaurin alpha, putative	0.0088	0.0083	0.0532
Echinococcus granulosus	pdz domain containing protein	0.0088	0.0083	0.0094
Brugia malayi	regulator of G-protein signaling rgs-7	0.0961	0.1566	0.1562
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0061	0.0037	0.0033
Brugia malayi	Fibronectin type III domain containing protein	0.0121	0.0139	0.0135
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Echinococcus multilocularis	roundabout 2	0.0121	0.0139	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0961	0.1566	0.1562
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0139	0.0135
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Schistosoma mansoni	hypothetical protein	0.0088	0.0083	0.0072
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	oxysterol binding protein 1	0.0088	0.0083	0.0094
Schistosoma mansoni	regulator of G protein signaling	0.0961	0.1566	0.1556
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0061	0.0037	0.0033
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0077	0.0257
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0061	0.0037	0.0039
Echinococcus granulosus	neuroglian	0.0116	0.0131	0.0151
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	regulator of G protein signaling 3	0.0961	0.1566	0.1867
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Toxoplasma gondii	hypothetical protein	0.0088	0.0083	0.5393
Schistosoma mansoni	z-protein (S1r protein)	0.0961	0.1566	0.1556
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	exocyst complex component 2	0.0179	0.0238	0.0279
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0088	0.0083	0.0079
Loa Loa (eye worm)	TK/INSR protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0061	0.0037	0.0239
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0083	0.0301
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0061	0.0037	0.0239
Brugia malayi	A-kinase anchor protein 10, precursor	0.0961	0.1566	0.1562
Giardia lamblia	Kinase	0.0061	0.0037	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0061	0.0037	0.0039
Trichomonas vaginalis	TK family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0221	0.031	0.0305
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0111	0.0123	1
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0111	0.0123	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0177	0.0235	0.023
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	protein tyrosine kinase	0.0061	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0979	0.1597	0.1593
Echinococcus multilocularis	insulin receptor	0.0061	0.0037	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0961	0.1566	0.1867
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	Tyrosine-protein kinase PR2	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0061	0.0037	0.0033
Echinococcus granulosus	c src tyrosine kinase	0.0061	0.0037	0.0039
Echinococcus granulosus	Immunoglobulin	0.0116	0.0131	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Onchocerca volvulus		0.0088	0.0083	0.0295
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Brugia malayi	Dynamin	0.0088	0.0083	0.0079
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0088	0.0083	0.0094
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0088	0.0083	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Toxoplasma gondii	protein kinase domain-containing protein	0.0111	0.0123	1
Trichomonas vaginalis	centaurin beta, putative	0.0088	0.0083	0.0532
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Toxoplasma gondii	Oxysterol-binding protein	0.0088	0.0083	0.5393
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0088	0.0083	0.0079
Brugia malayi	Cytohesin 3	0.0088	0.0083	0.0079
Schistosoma mansoni	protein tyrosine kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.454	0.7649	0.7647
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0088	0.0083	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0238	0.0234
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	Pleckstrin y	0.0088	0.0083	0.0094
Schistosoma mansoni	vesicular amine transporter	0.0119	0.0135	0.0124
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	tyrosine protein kinase Blk	0.0061	0.0037	0.0039
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0037	0.0026
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0061	0.0037	0.0039
Schistosoma mansoni	hypothetical protein	0.0409	0.0629	0.0618
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	TK/ABL protein kinase	0.0061	0.0037	0.0033
Echinococcus granulosus	raf serine:threonine protein kinase	0.0061	0.0037	0.0039
Trichomonas vaginalis	hypothetical protein	0.0088	0.0083	0.0532
Brugia malayi	probable spectrin beta chain	0.0088	0.0083	0.0079
Schistosoma mansoni	vav2	0.0088	0.0083	0.0072
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Onchocerca volvulus	Protein melted homolog	0.0088	0.0083	0.0295
Brugia malayi	hypothetical protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Echinococcus multilocularis	neuroglian	0.0116	0.0131	0.0151
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Schistosoma mansoni	oxysterol-binding protein 1	0.0088	0.0083	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0131	0.0126
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0061	0.0037	0.0039
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0061	0.0037	0.0026
Loa Loa (eye worm)	TK/CSK protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0961	0.1566	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0111	0.0123	0.0112
Schistosoma mansoni	semaphorin 5-related	0.0409	0.0629	0.0618
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	centaurin alpha	0.0088	0.0083	0.0072
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Echinococcus multilocularis	cytohesin 1	0.0088	0.0083	0.0094
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0088	0.0083	0.5393
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Loa Loa (eye worm)	TK/RYK protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0088	0.0083	0.0079
Brugia malayi	SH2 domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	centaurin/arf, putative	0.0088	0.0083	0.0532
Entamoeba histolytica	hypothetical protein	0.0179	0.0238	0.1313
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0111	0.0123	0.0783
Echinococcus multilocularis	oxysterol binding protein 3	0.0088	0.0083	0.0094
Echinococcus multilocularis	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0961	0.1566	1
Brugia malayi	Oxysterol-binding protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	defective proboscis extension response	0.0116	0.0131	0.0151
Echinococcus granulosus	activated cdc42 kinase 1	0.0061	0.0037	0.0039
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0116	0.0131	0.0151
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0088	0.0083	0.0079
Brugia malayi	Pleckstrin Homology Domain	0.0088	0.0083	0.0079
Schistosoma mansoni	serine/threonine-protein kinase	0.0111	0.0123	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0088	0.0083	0.0094
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Onchocerca volvulus		0.0088	0.0083	0.0295
Plasmodium falciparum	protein kinase, putative	0.0084	0.0077	0.4607
Giardia lamblia	Kinase, NEK	0.0061	0.0037	0.5
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Trypanosoma cruzi	NIMA-related kinase, putative	0.0111	0.0123	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0123	0.0557
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Plasmodium vivax	hypothetical protein, conserved	0.0088	0.0083	0.5393
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0116	0.0131	0.012
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus granulosus	GRB2 associated binding protein 3	0.0088	0.0083	0.0094
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus multilocularis	Pleckstrin y	0.0088	0.0083	0.0094
Plasmodium vivax	PH domain containing protein	0.0088	0.0083	0.5393
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0061	0.0037	0.0033
Echinococcus granulosus	Pleckstrin y	0.0088	0.0083	0.0094
Schistosoma mansoni	hypothetical protein	0.0088	0.0083	0.0072
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0088	0.0083	0.0295
Onchocerca volvulus		0.0088	0.0083	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0061	0.0037	0.0039
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0961	0.1566	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0409	0.0629	0.0624
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0123	0.0557
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Echinococcus granulosus	regulator of G protein signaling 3	0.0961	0.1566	0.1867
Echinococcus granulosus	insulin receptor	0.0061	0.0037	0.0039
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	Guanylyl cyclase protein 23	0.0061	0.0037	0.0033
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0088	0.0083	0.0301
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0961	0.1566	0.1867
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0961	0.1566	0.1562
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0179	0.0238	0.1521
Brugia malayi	TBC domain containing protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	TK/ACK protein kinase	0.0061	0.0037	0.0033
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0088	0.0083	0.5393
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Schistosoma mansoni	regulator of G protein signaling	0.0961	0.1566	0.1556
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0088	0.0083	0.0072
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0088	0.0083	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0409	0.0629	0.0624
Leishmania major	hypothetical protein, conserved	0.0088	0.0083	0.5393
Loa Loa (eye worm)	rho-GTPase-activating	0.0088	0.0083	0.0079
Loa Loa (eye worm)	uncoordinated protein 104	0.0088	0.0083	0.0079
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0061	0.0037	0.0033
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0111	0.0123	1
Onchocerca volvulus	outspread protein homolog	0.0088	0.0083	0.0295
Echinococcus multilocularis	axis inhibition protein axin	0.0961	0.1566	0.1867
Schistosoma mansoni	ephrin receptor	0.0061	0.0037	0.0026
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0131	0.0126
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0088	0.0083	0.0094
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0409	0.0629	0.0624
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Brugia malayi	plexin A	0.1158	0.1902	0.1898
Schistosoma mansoni	serine/threonine protein kinase	0.454	0.7649	0.7647
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0409	0.0629	0.0624
Entamoeba histolytica	protein kinase domain containing protein	0.024	0.0342	0.1993
Brugia malayi	PXA domain containing protein	0.0961	0.1566	0.1562
Brugia malayi	Probable exocyst complex component Sec5	0.0179	0.0238	0.0234
Trichomonas vaginalis	centaurin gamma, putative	0.0088	0.0083	0.0532
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0088	0.0083	0.0094
Echinococcus granulosus	transcription factor collier	0.0179	0.0238	0.0279
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Echinococcus multilocularis	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Brugia malayi	hypothetical protein	0.0961	0.1566	0.1562
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0111	0.0123	1
Onchocerca volvulus		0.0088	0.0083	0.0295
Trypanosoma brucei	protein kinase, putative	0.0084	0.0077	0.4607
Echinococcus granulosus	serine/threonine protein kinase	0.0111	0.0123	0.0141
Entamoeba histolytica	hypothetical protein	0.0088	0.0083	0.0301
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0179	0.0238	0.1521
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	integrin linked protein kinase	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0131	0.0126
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0111	0.0123	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Echinococcus granulosus	DCC interacting protein 13 beta	0.0088	0.0083	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Schistosoma mansoni	cell adhesion molecule	0.0121	0.0139	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0961	0.1566	1
Echinococcus granulosus	epidermal growth factor receptor	0.0061	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Leishmania major	serine/threonine-protein kinase a, putative	0.0111	0.0123	1
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0961	0.1566	0.1562
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	regulator of G protein signaling 7	0.0961	0.1566	0.1867
Entamoeba histolytica	PH domain containing protein	0.0088	0.0083	0.0301
Echinococcus granulosus	receptor type guanylyl cyclase	0.0061	0.0037	0.0039
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0084	0.0077	0.0086
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0123	0.0557
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0088	0.0083	0.5393
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0061	0.0037	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0238	0.0234
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0111	0.0123	1
Loa Loa (eye worm)	SRC-1	0.0061	0.0037	0.0033
Schistosoma mansoni	regulator of G protein signaling	0.0961	0.1566	0.1556
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0088	0.0083	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0066	0.0046	0.005
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.454	0.7649	0.7648
Trichomonas vaginalis	CAMK family protein kinase	0.0061	0.0037	0.0239
Trypanosoma cruzi	NIMA-related kinase, putative	0.0111	0.0123	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0061	0.0037	0.0039
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	centaurin/arf, putative	0.0088	0.0083	0.0532
Brugia malayi	regulator of G-protein signaling egl-10	0.0961	0.1566	0.1562
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0061	0.0037	0.0039
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0061	0.0037	0.0039
Echinococcus granulosus	activated cdc42 kinase 1	0.0061	0.0037	0.0039
Schistosoma mansoni	hypothetical protein	0.0088	0.0083	0.0072
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.5923	1	1
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Plasmodium falciparum	oxysterol-binding protein, putative	0.0088	0.0083	0.5393
Echinococcus granulosus	regulator of G protein signaling 7	0.0961	0.1566	0.1867
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0061	0.0037	0.0039
Schistosoma mansoni	zinc finger protein	0.0088	0.0083	0.0072
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0088	0.0083	0.0532
Schistosoma mansoni	nephrin	0.0121	0.0139	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Entamoeba histolytica	hypothetical protein	0.0111	0.0123	0.0557
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0088	0.0083	0.0094
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	hypothetical protein	0.0179	0.0238	0.0227
Entamoeba histolytica	PH domain containing protein	0.0088	0.0083	0.0301
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Onchocerca volvulus		0.0088	0.0083	0.0295
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Echinococcus granulosus	Pleckstrin y	0.0088	0.0083	0.0094
Echinococcus multilocularis	regulator of G protein signaling	0.0961	0.1566	0.1867
Echinococcus multilocularis	regulator of G protein signaling 3	0.0961	0.1566	0.1867
Brugia malayi	Variant SH3 domain containing protein	0.0088	0.0083	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0961	0.1566	0.1562
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0061	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Leishmania major	hypothetical protein, conserved	0.0088	0.0083	0.5393
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0088	0.0083	0.5393
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0179	0.0238	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0409	0.0629	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	hypothetical protein	0.0409	0.0629	0.0624
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0179	0.0238	0.1521
Entamoeba histolytica	hypothetical protein	0.0961	0.1566	1
Schistosoma mansoni	hypothetical protein	0.0088	0.0083	0.0072
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Echinococcus multilocularis	c src tyrosine kinase	0.0061	0.0037	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0088	0.0083	0.0094
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0061	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0061	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0088	0.0083	0.5393
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0061	0.0037	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	TK/ROR protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0061	0.0037	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	epidermal growth factor receptor	0.0061	0.0037	0.0039
Echinococcus granulosus	tyrosine protein kinase	0.0061	0.0037	0.0039
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0061	0.0037	0.0033
Echinococcus multilocularis	epidermal growth factor receptor	0.0061	0.0037	0.0039
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Trichomonas vaginalis	kinesin light chain, putative	0.0088	0.0083	0.0532
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	kinase suppressor of Ras 1	0.0061	0.0037	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Echinococcus multilocularis	myotubularin protein 13	0.0088	0.0083	0.0094
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0088	0.0083	0.0072
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0088	0.0083	0.0094
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0961	0.1566	0.1562
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0088	0.0083	0.0094
Echinococcus multilocularis	protein kinase	0.0061	0.0037	0.0039
Echinococcus granulosus	plexin a4	0.1158	0.1902	0.2268
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0083	0.5393
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Entamoeba histolytica	hypothetical protein	0.0088	0.0083	0.0301
Trypanosoma brucei	PH domain containing protein, putative	0.0088	0.0083	0.5393
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Loa Loa (eye worm)	plexin A	0.1158	0.1902	0.1898
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Echinococcus multilocularis	Oxysterol binding protein 11	0.0088	0.0083	0.0094
Loa Loa (eye worm)	oxysterol binding protein	0.0088	0.0083	0.0079
Brugia malayi	Raf kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	syntrophin-1	0.0088	0.0083	0.0079
Echinococcus granulosus	tyrosine kinase	0.0061	0.0037	0.0039
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus multilocularis	semaphorin 5B	0.0409	0.0629	0.0746
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0238	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	FL cytokine receptor	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0961	0.1566	0.1562
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.5923	1	1
Echinococcus granulosus	Regulator of G protein signaling 20	0.0961	0.1566	0.1867
Echinococcus multilocularis	heat shock protein 70	0.0061	0.0037	0.0039
Plasmodium falciparum	PH domain-containing protein, putative	0.0088	0.0083	0.5393
Schistosoma mansoni	rho gtpase activating protein	0.0088	0.0083	0.0072
Onchocerca volvulus		0.0088	0.0083	0.0295
Entamoeba histolytica	PH domain containing protein	0.0088	0.0083	0.0301
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0111	0.0123	1
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Echinococcus multilocularis	Pleckstrin y	0.0088	0.0083	0.0094
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.358	0.6017	0.7189
Entamoeba histolytica	hypothetical protein	0.0111	0.0123	0.0557
Brugia malayi	Variant SH3 domain containing protein	0.0088	0.0083	0.0079
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0083	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0061	0.0037	0.0039
Brugia malayi	hypothetical protein	0.0088	0.0083	0.0079
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0061	0.0037	0.0033
Brugia malayi	Tyrosine-protein kinase abl-1	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0061	0.0037	0.0026
Echinococcus granulosus	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0088	0.0083	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Schistosoma mansoni	myotubularin-related protein	0.0088	0.0083	0.0072
Onchocerca volvulus	Putative zinc finger protein	0.0088	0.0083	0.0295
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0961	0.1566	0.1556
Brugia malayi	ephrin receptor 1 precursor	0.0061	0.0037	0.0033
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0061	0.0037	0.0039
Echinococcus granulosus	tyrosine kinase	0.0061	0.0037	0.0039
Echinococcus granulosus	tyrosine protein kinase csk	0.0061	0.0037	0.0039
Echinococcus multilocularis	regulator of G protein signaling 3	0.0961	0.1566	0.1867
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Schistosoma mansoni	hypothetical protein	0.0088	0.0083	0.0072
Brugia malayi	Uncoordinated protein 104	0.0088	0.0083	0.0079
Brugia malayi	hypothetical protein	0.0409	0.0629	0.0624
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0111	0.0123	1
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0088	0.0083	0.0094
Echinococcus multilocularis	Immunoglobulin	0.0116	0.0131	0.0151
Leishmania major	folate/biopterin transporter, putative	0.0111	0.0123	1
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0083	0.5393
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0088	0.0083	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0139	0.0135
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0111	0.0123	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0061	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0037	0.0026
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0061	0.0037	0.0039
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0084	0.0077	0.0086
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0061	0.0037	0.0039
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0111	0.0123	1
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	plexin a4	0.1158	0.1902	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	roundabout 2	0.0121	0.0139	0.0161
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Echinococcus multilocularis	tyrosine kinase	0.0061	0.0037	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus granulosus	myotubularin protein 13	0.0088	0.0083	0.0094
Schistosoma mansoni	protein kinase	0.0084	0.0077	0.0066
Echinococcus granulosus	expressed protein	0.0961	0.1566	0.1867
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Echinococcus multilocularis	axis inhibition protein axin	0.0961	0.1566	0.1867
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0061	0.0037	0.0039
Entamoeba histolytica	hypothetical protein	0.0088	0.0083	0.0301
Entamoeba histolytica	hypothetical protein, conserved	0.0088	0.0083	0.0301
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0088	0.0083	0.0072
Schistosoma mansoni	regulator of G protein signaling	0.0961	0.1566	0.1556
Schistosoma mansoni	plexin	0.0979	0.1597	0.1588
Onchocerca volvulus		0.0088	0.0083	0.0295
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0179	0.0238	0.1521
Echinococcus granulosus	tyrosine protein kinase Srms	0.0061	0.0037	0.0039
Brugia malayi	hypothetical protein	0.0061	0.0037	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0111	0.0123	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0961	0.1566	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus granulosus	axis inhibition protein axin	0.0961	0.1566	0.1867
Echinococcus granulosus	activin receptor type	0.0084	0.0077	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Onchocerca volvulus		0.0409	0.0629	0.3791
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Brugia malayi	Oxysterol binding protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0088	0.0083	0.0094
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0061	0.0037	0.0026
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0061	0.0037	0.0039
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0088	0.0083	0.0532
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0088	0.0083	0.0532
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4963	0.8368	0.8367
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4963	0.8368	0.8367
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Brugia malayi	Syntrophin-1	0.0088	0.0083	0.0079
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0088	0.0083	0.5393
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Entamoeba histolytica	hypothetical protein	0.0179	0.0238	0.1313
Brugia malayi	PXA domain containing protein	0.0961	0.1566	0.1562
Entamoeba histolytica	hypothetical protein	0.0179	0.0238	0.1313
Loa Loa (eye worm)	Plekhf2 protein	0.0088	0.0083	0.0079
Echinococcus multilocularis	pdz domain containing protein	0.0088	0.0083	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Toxoplasma gondii	AtPH1 family protein	0.0088	0.0083	0.5393
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Echinococcus multilocularis	expressed protein	0.0961	0.1566	0.1867
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Echinococcus granulosus	protein tyrosine kinase	0.0061	0.0037	0.0039
Schistosoma mansoni	protein kinase	0.0084	0.0077	0.0066
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Schistosoma mansoni	goodpasture antigen-binding protein	0.0088	0.0083	0.0072
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	hypothetical protein	0.0121	0.0139	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0961	0.1566	0.1562
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0961	0.1566	0.1867
Brugia malayi	MAX-1A	0.0088	0.0083	0.0079
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0131	0.0126
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0061	0.0037	0.0039
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Trichomonas vaginalis	protein transport protein sec7, putative	0.0088	0.0083	0.0532
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0131	0.0126
Schistosoma mansoni	protein kinase	0.0061	0.0037	0.0026
Trichomonas vaginalis	protein transport protein sec7, putative	0.0088	0.0083	0.0532
Echinococcus granulosus	calcium dependent secretion activator 1	0.0088	0.0083	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0037	0.0239
Trichomonas vaginalis	alpha chimerin, putative	0.0088	0.0083	0.0532
Loa Loa (eye worm)	TK/EPH protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0131	0.0126
Trypanosoma cruzi	hypothetical protein	0.0088	0.0083	0.5393
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0037	0.0033
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0088	0.0083	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0961	0.1566	0.1562
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4963	0.8368	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0083	0.0301
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	Pleckstrin y	0.0088	0.0083	0.0094
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Schistosoma mansoni	zinc finger protein	0.0088	0.0083	0.0072
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	0.0037	0.0033
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	0.0037	0.0039
Brugia malayi	PH domain containing protein	0.0088	0.0083	0.0079
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0061	0.0037	0.0039
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0177	0.0235	0.023
Echinococcus granulosus	G protein coupled receptor kinase 1	0.358	0.6017	0.7189
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0.0077	0.4607
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	tyrosine protein kinase	0.0061	0.0037	0.0039
Echinococcus granulosus	integrin linked protein kinase	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Giardia lamblia	Kinase, NEK	0.0061	0.0037	0.5
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0037	0.0033
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0061	0.0037	0.0026
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0061	0.0037	0.0039
Entamoeba histolytica	p21-activated kinase	0.0111	0.0123	0.0557
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trypanosoma brucei	protein kinase, putative	0.0111	0.0123	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0061	0.0037	0.0033
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0111	0.0123	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0061	0.0037	0.0039
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0116	0.0131	0.0151
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0083	0.0301
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0111	0.0123	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0312	0.0465	0.046
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0088	0.0083	0.0295
Echinococcus multilocularis	epidermal growth factor receptor	0.0061	0.0037	0.0039
Echinococcus granulosus	tyrosine kinase	0.0061	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Schistosoma mansoni	plexin	0.057	0.0902	0.0892
Schistosoma mansoni	tyrosine protein kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	hypothetical protein	0.0179	0.0238	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Echinococcus granulosus	ephrin type A receptor 4 A	0.0061	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Schistosoma mansoni	fibrocystin l	0.0179	0.0238	0.0227
Giardia lamblia	Protein 21.1	0.0061	0.0037	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0037	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Echinococcus multilocularis	tyrosine kinase	0.0061	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0061	0.0037	0.0026
Schistosoma mansoni	hypothetical protein	0.057	0.0902	0.0892
Echinococcus multilocularis	regulator of G protein signaling 7	0.0961	0.1566	0.1867
Trichomonas vaginalis	conserved hypothetical protein	0.0961	0.1566	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0061	0.0037	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Echinococcus multilocularis	dynamin 1	0.0088	0.0083	0.0094
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0061	0.0037	0.0039
Entamoeba histolytica	hypothetical protein	0.0961	0.1566	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.454	0.7649	0.9141
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0088	0.0083	0.0532
Entamoeba histolytica	hypothetical protein	0.0088	0.0083	0.0301
Trichomonas vaginalis	TKL family protein kinase	0.0061	0.0037	0.0239
Loa Loa (eye worm)	sema domain-containing protein	0.0409	0.0629	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0121	0.0139	0.0135
Schistosoma mansoni	growth factor receptor-bound protein	0.0088	0.0083	0.0072
Entamoeba histolytica	protein kinase, putative	0.0111	0.0123	0.0557
Echinococcus granulosus	exocyst complex component 2	0.0179	0.0238	0.0279
Echinococcus granulosus	protein kinase	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0083	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Entamoeba histolytica	hypothetical protein	0.0179	0.0238	0.1313
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0123	0.0783
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0083	0.0532
Loa Loa (eye worm)	PH domain-containing protein	0.0088	0.0083	0.0079
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0061	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.057	0.0902	0.0898
Schistosoma mansoni	regulator of G protein signaling	0.0961	0.1566	0.1556
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0061	0.0037	0.0039

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1533787

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1385461