Detailed information for compound 138687

Basic information

Technical information
  • TDR Targets ID: 138687
  • Name: 4-(3,4-dimethoxyphenyl)-2-phenacyl-4a,5,6,7,8 ,8a-hexahydrophthalazin-1-one
  • MW: 406.474 | Formula: C24H26N2O4
  • H donors: 0 H acceptors: 2 LogP: 4.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1=NN(CC(=O)c2ccccc2)C(=O)C2C1CCCC2
  • InChi: 1S/C24H26N2O4/c1-29-21-13-12-17(14-22(21)30-2)23-18-10-6-7-11-19(18)24(28)26(25-23)15-20(27)16-8-4-3-5-9-16/h3-5,8-9,12-14,18-19H,6-7,10-11,15H2,1-2H3
  • InChiKey: HMKJSFGZWJJYNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3,4-dimethoxyphenyl)-2-(2-oxo-2-phenylethyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1-one
  • 4-(3,4-dimethoxyphenyl)-2-(2-oxo-2-phenyl-ethyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1-one
  • 4-(3,4-dimethoxyphenyl)-2-(2-keto-2-phenyl-ethyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4A, cAMP-specific References
Homo sapiens phosphodiesterase 4C, cAMP-specific References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4B, cAMP-specific References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus netrin receptor unc 5 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0029 0.0027
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0012 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Echinococcus multilocularis carbonic anhydrase II 0.0213 0.0135 0.0135
Loa Loa (eye worm) polyprenyl synthetase 0.4173 0.2761 0.2761
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0012 0.0012
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0025 0.0024
Echinococcus multilocularis integrin beta 2 0.0259 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0005
Mycobacterium ulcerans hypothetical protein 0.0023 0.0009 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0007 0.0005
Echinococcus multilocularis hexokinase 0.0468 0.0304 0.0304
Plasmodium vivax phosphodiesterase gamma, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis cpg binding protein 0.0029 0.0013 0.0013
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0447 0.029 0.029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.4173 0.2761 0.276
Brugia malayi MH2 domain containing protein 0.0115 0.007 0.0069
Loa Loa (eye worm) inositol-1 0.0194 0.0122 0.0122
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0013 0.0002 0.0002
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 1.5085 1 1
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 1.5085 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0118 0.0071 0.0071
Schistosoma mansoni jumonji domain containing protein 0.0013 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0213 0.0135 0.0135
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0028 0.0028
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0096 0.0057 0.0198
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0447 0.029 0.0289
Toxoplasma gondii peptidylprolyl isomerase 0.0096 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.4173 0.2761 0.276
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0016 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0029 0.0013 0.0013
Leishmania major DNA polymerase eta, putative 0.0015 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0053 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0194 0.0122 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0142 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative 0.0015 0.0003 0.0001
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0002 0.0002
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0194 0.0122 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.023 0.0146 0.0146
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0003 0.0001
Onchocerca volvulus 0.0028 0.0012 0.0368
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Leishmania major tyrosine specific protein phosphatase, putative 0.0013 0.0002 0.0000065691
Schistosoma mansoni hypothetical protein 0.0299 0.0192 0.0191
Leishmania major carbonic anhydrase-like protein 0.0213 0.0135 0.0133
Echinococcus granulosus geminin 0.0329 0.0211 0.0211
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Schistosoma mansoni inositol monophosphatase 0.0194 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni phosphatidylserine receptor 0.0013 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0073 0.0042 0.0041
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 1.5085 1 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0092 0.0092
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0064
Leishmania major DNA damage repair protein, putative 0.0015 0.0003 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0013 0.0002 0.0002
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0054 0.0029 0.0029
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0098 0.0058 0.0058
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0013 0.0002 0.0049
Brugia malayi hypothetical protein 0.0013 0.0002 0.0001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0194 0.0122 0.012
Leishmania major squalene synthase, putative 0.0455 0.0295 0.0293
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0001 0.0006
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0016 0.0004 0.0004
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0029 0.0029
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0033 0.0031
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.4173 0.2761 0.2761
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.002 0.0007 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0001 0.0001
Loa Loa (eye worm) hexokinase type II 0.0468 0.0304 0.0304
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0013 0.0002 0.0001
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Leishmania major hexokinase, putative 0.0468 0.0304 0.0302
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0013 0.0002 0.0002
Echinococcus multilocularis inositol monophosphatase 0.002 0.0007 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0018 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) MBCTL1 0.0053 0.0029 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Trypanosoma cruzi hexokinase, putative 0.0468 0.0304 0.0302
Onchocerca volvulus 0.0037 0.0018 0.0563
Brugia malayi intermediate filament protein 0.0053 0.0029 0.0028
Brugia malayi Protein-tyrosine phosphatase 1 0.0013 0.0002 0.0001
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0016 0.0004 0.0004
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 1.5085 1 1
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.3292 0.2177 0.2175
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Echinococcus multilocularis Squalene phytoene synthase 0.0142 0.0088 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0004 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Mycobacterium ulcerans monophosphatase 0.002 0.0007 0.0004
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.3292 0.2177 0.2175
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.0078 0.0077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Schistosoma mansoni ran 0.0021 0.0007 0.0006
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0024 0.0777
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0001 0.0006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0064
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0012 0.001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0012 0.0012
Brugia malayi mbt repeat family protein 0.0046 0.0024 0.0024
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0029 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0287 0.0184 0.6035
Schistosoma mansoni cpg binding protein 0.0029 0.0013 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0029 0.0027
Brugia malayi Polyprenyl synthetase family protein 0.4173 0.2761 0.2761
Brugia malayi RNA, U transporter 1 0.008 0.0046 0.0046
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0049 0.0026 0.0026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0018 0.0018
Echinococcus granulosus phd:f box containing protein 0.0013 0.0002 0.0002
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0213 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0053 0.0029 0.0029
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0085 0.005 0.005
Loa Loa (eye worm) protein tyrosine phosphatase 0.0013 0.0002 0.0002
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0013 0.0002 0.0001
Echinococcus multilocularis netrin receptor unc 5 0.0011 0.0001 0.0001
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.4173 0.2761 0.276
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0013 0.0002 0.0002
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0447 0.029 0.029
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.002 0.0007 0.0005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.002 0.0007 0.0005
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0013 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0029 0.0028
Onchocerca volvulus 0.0013 0.0002 0.0049
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0013 0.0002 0.0000065691
Schistosoma mansoni hypothetical protein 0.0286 0.0183 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.002 0.0007 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0085 0.005 0.0049
Trypanosoma cruzi DNA damage repair protein, putative 0.0015 0.0003 0.0001
Echinococcus granulosus nuclear factor of activated T cells 5 0.0056 0.0031 0.0031
Trypanosoma brucei unspecified product 0.0085 0.005 0.0048
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0008 0.0006
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.002 0.0007 0.0206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0001
Brugia malayi mbt repeat family protein 0.0046 0.0024 0.0024
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.0003 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0001
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.023 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0052 0.0028 0.0028
Schistosoma mansoni phd/f-box containing protein 0.0013 0.0002 0.0001
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0254 0.0162 0.0162
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Leishmania major cathepsin L-like protease 0.0021 0.0007 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Echinococcus granulosus hexokinase 0.0468 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0058 0.0055
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0004 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0033 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0009 0.0008
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0054 0.0029 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0319 0.0205 0.0205
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0161 0.0161
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0029 0.0029
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0127 0.0078 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0029 0.0027
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0004 0.0003
Onchocerca volvulus 0.0013 0.0002 0.0049
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0025 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0049 0.0026 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0037 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0001
Treponema pallidum hexokinase (hxk) 0.0468 0.0304 0.0835
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0192 0.0192
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0003 0.0001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Entamoeba histolytica hexokinase 1 0.0468 0.0304 0.1094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Trypanosoma brucei squalene synthase, putative 0.0455 0.0295 0.0293
Mycobacterium ulcerans phytoene synthase, CrtB 0.0142 0.0088 0.0084
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0004 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0194 0.0122 0.0122
Echinococcus granulosus hexokinase type 2 0.0468 0.0304 0.0304
Schistosoma mansoni importin beta-1 0.0028 0.0012 0.0011
Loa Loa (eye worm) carbonic anhydrase 3 0.0213 0.0135 0.0135
Echinococcus granulosus dnaJ subfamily B 0.0395 0.0256 0.0256
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0004 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0085 0.005 0.0049
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Brugia malayi Hexokinase family protein 0.0468 0.0304 0.0303
Trypanosoma brucei hexokinase 0.0468 0.0304 0.0302
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0009 0.0006
Onchocerca volvulus 0.0468 0.0304 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0011 0.0001 0.0000061678
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Toxoplasma gondii polyprenyl synthetase superfamily protein 1.5085 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0018 0.0017
Mycobacterium tuberculosis Probable monophosphatase 0.002 0.0007 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.3292 0.2177 0.2175
Onchocerca volvulus 0.0013 0.0002 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0016 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0029 0.0013 0.0012
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0392 0.0254 0.0254
Trypanosoma brucei hexokinase 0.0468 0.0304 0.0302
Brugia malayi jmjC domain containing protein 0.0013 0.0002 0.0001
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0056 0.0031 0.0031
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0012 0.001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0001
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0098 0.0058 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0049 0.0026 0.0026
Giardia lamblia Hypothetical protein 0.0054 0.0029 0.0027
Brugia malayi hypothetical protein 0.004 0.002 0.0019
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0029 0.0029
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0054 0.0029 0.0029
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0051 0.0027 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0058 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.4428 0.2931 1
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.3292 0.2177 0.2175
Schistosoma mansoni hexokinase 0.0468 0.0304 0.0303
Brugia malayi hypothetical protein 0.0013 0.0002 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0029 0.0027
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0194 0.0122 0.012
Schistosoma mansoni carbonic anhydrase-related 0.0127 0.0078 0.0077
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0038 0.0019 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0127 0.0078 0.0077
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0039 0.0019 0.0019
Trypanosoma cruzi squalene synthase, putative 0.0455 0.0295 0.0293
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0001 0.0001
Mycobacterium leprae PROBABLE HYDROLASE 0.0063 0.0035 0.0103
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.007 0.007
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0159 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0018 0.0018
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0024 0.0024
Echinococcus granulosus importin subunit beta 1 0.0028 0.0012 0.0012
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0029 0.0029
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0127 0.0078 0.0078
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0016 0.0004 0.0004
Plasmodium falciparum DNA repair protein REV1, putative 0.0015 0.0003 0.0001
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0013 0.0002 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0019 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0002 0.0002
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.4428 0.2931 0.293
Echinococcus multilocularis musashi 0.0053 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0054 0.0029 0.0027
Trichomonas vaginalis DNA polymerase eta, putative 0.0098 0.0058 0.0056
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0013 0.0002 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0001
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0254 0.0162 0.0162
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0025 0.0024
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0098 0.0058 0.0056
Echinococcus multilocularis lysine specific demethylase 6a 0.0013 0.0002 0.0002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.4173 0.2761 0.276
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.3292 0.2177 0.2175
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0001 0.0006
Loa Loa (eye worm) hexokinase 0.0468 0.0304 0.0304
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.4173 0.2761 1
Schistosoma mansoni protein phosphatase 2C 0.0013 0.0002 0.0001
Brugia malayi Integrin beta pat-3 precursor 0.0353 0.0228 0.0227
Brugia malayi Matrixin family protein 0.0052 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.5433 0.3597 0.3597
Echinococcus granulosus lamin dm0 0.0053 0.0029 0.0029
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.002 0.0007 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.005 0.0048
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Schistosoma mansoni pap-inositol-14-phosphatase 0.002 0.0007 0.0006
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0049 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0061 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0064
Leishmania major hypothetical protein, conserved 0.0142 0.0088 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0009 0.0023
Schistosoma mansoni trans-prenyltransferase 0.4173 0.2761 0.2761
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0142 0.0088 0.2862
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0009 0.0008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0194 0.0122 0.0405
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0194 0.0122 0.012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0005 0.0002
Brugia malayi Matrixin family protein 0.0191 0.012 0.012
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.0029 0.0027
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.007 0.007
Brugia malayi hexokinase 0.0468 0.0304 0.0303
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Onchocerca volvulus Matrix metalloproteinase homolog 0.0115 0.007 0.2273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0002 0.0002
Treponema pallidum octaprenyl-diphosphate synthase 0.5433 0.3597 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Schistosoma mansoni protein tyrosine phosphatase 0.0016 0.0004 0.0004
Brugia malayi Inositol monophosphatase family protein 0.002 0.0007 0.0006
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0029 0.0027
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0054 0.0029 0.0029
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma brucei chrX additional, unordered contigs 0.0015 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus snurportin 1 0.0299 0.0192 0.0192
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0013 0.0002 0.0049
Echinococcus multilocularis snurportin 1 0.0299 0.0192 0.0192
Echinococcus granulosus dna polymerase kappa 0.0098 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Echinococcus granulosus hexokinase 0.0468 0.0304 0.0304
Brugia malayi Pre-SET motif family protein 0.0252 0.0161 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0037 0.0034
Brugia malayi Pre-SET motif family protein 0.0037 0.0018 0.0017
Schistosoma mansoni ran 0.0021 0.0007 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0013 0.0002 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0025 0.0023
Echinococcus granulosus dna polymerase eta 0.0047 0.0025 0.0025
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 1.5085 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0065 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus farnesyl pyrophosphate synthase 1.5085 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.0078 0.0077
Schistosoma mansoni hypothetical protein 0.0329 0.0211 0.0211
Onchocerca volvulus 0.0013 0.0002 0.0049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0447 0.029 0.029
Trypanosoma brucei carbonic anhydrase-like protein 0.0213 0.0135 0.0133
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0054 0.0029 0.0029
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.0256 0.0256
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0194 0.0122 0.012
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0149 0.0092 0.0092
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0002 0.0002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0009 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0392 0.0254 0.0253
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0024 0.0024
Trypanosoma brucei DNA damage repair protein, putative 0.0015 0.0003 0.0001
Giardia lamblia DINP protein human, muc B family 0.006 0.0033 0.0031
Schistosoma mansoni hypothetical protein 0.0155 0.0096 0.0095
Echinococcus granulosus protein tyrosine phosphatase n9 0.0013 0.0002 0.0002
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Echinococcus granulosus carbonic anhydrase 0.0127 0.0078 0.0078
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0004 0.0004
Brugia malayi Uncoordinated protein 44 0.0011 0.0001 0.000000001423
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0004 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0008 0.0006
Echinococcus multilocularis carbonic anhydrase 0.0127 0.0078 0.0078
Schistosoma mansoni myo inositol monophosphatase 0.002 0.0007 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0054 0.0029 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Schistosoma mansoni protein tyrosine phosphatase 0.0013 0.0002 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Brugia malayi Importin beta-1 subunit 0.0028 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus integrin beta 2 0.0259 0.0165 0.0165
Leishmania major cAMP-specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma cruzi polyprenyl synthase, putative 0.5433 0.3597 0.3596
Plasmodium falciparum carbonic anhydrase 0.0127 0.0078 0.0076
Brugia malayi hypothetical protein 0.0013 0.0002 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Death domain containing protein 0.0011 0.0001 0.000000001423
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0054 0.0029 0.0029
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0054 0.0029 0.0029
Entamoeba histolytica hexokinase 2 0.0468 0.0304 0.1094
Onchocerca volvulus 0.0013 0.0002 0.0049
Brugia malayi hypothetical protein 0.0013 0.0002 0.0001
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0055 0.003 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0055 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0447 0.029 0.029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0447 0.029 0.0288
Onchocerca volvulus 0.0013 0.0002 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Leishmania major cathepsin L-like protease 0.0021 0.0007 0.0005
Onchocerca volvulus Matrilysin homolog 0.0181 0.0113 0.3713
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0025 0.0025
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Echinococcus granulosus Squalene phytoene synthase 0.0142 0.0088 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0029 0.0027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0194 0.0122 0.0436
Echinococcus multilocularis jumonji domain containing 1A 0.0013 0.0002 0.0002
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.4173 0.2761 0.276
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0054 0.0029 0.0027
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0174 0.0109 0.0107
Brugia malayi Protein-tyrosine phosphatase 0.0013 0.0002 0.0001
Schistosoma mansoni DNA polymerase IV / kappa 0.0015 0.0003 0.0002
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0118 0.0071 0.0071
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0002 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.004 0.002 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0021 0.0007 0.0005
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0054 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis lamin 0.0053 0.0029 0.0029
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0096 0.0057 0.0055
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.0029 0.0027
Schistosoma mansoni lipoxygenase 0.0027 0.0011 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0009 0.0007
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0029 0.0029
Trypanosoma brucei unspecified product 0.0033 0.0015 0.0013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Loa Loa (eye worm) hexokinase 0.0468 0.0304 0.0304
Trypanosoma cruzi DNA damage repair protein, putative 0.0015 0.0003 0.0001
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.4173 0.2761 0.2761
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0025 0.0024
Onchocerca volvulus 4.1 G protein, putative homolog 0.0013 0.0002 0.0049
Schistosoma mansoni ap endonuclease 0.0016 0.0004 0.0003
Echinococcus multilocularis hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0029 0.0027
Toxoplasma gondii hypothetical protein 0.002 0.0007 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Trypanosoma brucei protein tyrosine phosphatase 1 0.0013 0.0002 0.0000065691
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0054 0.0029 0.0027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0004 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0002 0.0002
Trichomonas vaginalis inositol monophosphatase, putative 0.0194 0.0122 0.012
Schistosoma mansoni lamin 0.0053 0.0029 0.0028
Loa Loa (eye worm) matrix metalloproteinase 0.0052 0.0028 0.0028
Echinococcus granulosus carbonic anhydrase 0.0127 0.0078 0.0078
Mycobacterium ulcerans monophosphatase CysQ 0.002 0.0007 0.0004
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0013 0.0002 0.0002
Onchocerca volvulus 0.0013 0.0002 0.0049
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Giardia lamblia DNA damage repair protein 0.0015 0.0003 0.0001
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis Ankyrin 0.0011 0.0001 0.0001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0029 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0013 0.0002 0.0002
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0013 0.0002 0.0001
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0063 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0002 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0184 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Giardia lamblia hypothetical protein 0.0054 0.0029 0.0027
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0392 0.0254 0.0254
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0016 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0073 0.0042 0.1367
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0016 0.0016
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0007 0.0007
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0013 0.0002 0.0000065691
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.0023
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0002
Echinococcus granulosus JmjC domain containing protein 4 0.0013 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0009 0.0008
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0024 0.0024
Brugia malayi jmjC domain containing protein 0.0049 0.0026 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0058 0.0055
Schistosoma mansoni protein tyrosine phosphatase 0.0013 0.0002 0.0001
Leishmania major DNA polymerase kappa, putative 0.006 0.0033 0.0031
Onchocerca volvulus 0.0013 0.0002 0.0049
Schistosoma mansoni carbonic anhydrase-related 0.0127 0.0078 0.0077
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0054 0.0029 0.0027
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0213 0.0135 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0013 0.0011
Toxoplasma gondii hypothetical protein 0.0127 0.0078 0.0076
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.4173 0.2761 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0063 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0029
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0029 0.0029
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0054 0.0029 0.0029
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0174 0.0109 0.037
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0013 0.0002 0.0000065691
Leishmania major farnesyl pyrophosphate synthase 1.5085 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.001
Schistosoma mansoni intermediate filament proteins 0.0053 0.0029 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0085 0.005 0.005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0011 0.0001 0.0001
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.003 0.0013 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0013 0.0002 0.0049
Echinococcus multilocularis 0.0013 0.0002 0.0002
Trichomonas vaginalis rotamase, putative 0.0096 0.0057 0.0055
Onchocerca volvulus 0.0053 0.0029 0.0924
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0011 0.0001 0.0006
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0039 0.0019 0.0019
Echinococcus multilocularis geminin 0.0329 0.0211 0.0211
Brugia malayi Hexokinase family protein 0.0294 0.0188 0.0188
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0009 0.0006
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.0003 0.0001
Onchocerca volvulus 0.0013 0.0002 0.0049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.001 0.001
Leishmania major polyprenyl synthase, putative 0.5433 0.3597 0.3596
Loa Loa (eye worm) hypothetical protein 0.0063 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0213 0.0135 0.0133
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Trichomonas vaginalis ran, putative 0.0021 0.0007 0.0005
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.3292 0.2177 0.2175
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0054 0.0029 0.0029
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0392 0.0254 0.0254
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.002 0.0007 0.0005
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0013 0.0011
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0054 0.0029 0.0029
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0005 0.0003
Schistosoma mansoni carbonic anhydrase-related 0.0127 0.0078 0.0077
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0025
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0194 0.0122 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0013 0.0002 0.0049
Schistosoma mansoni inositol monophosphatase 0.0194 0.0122 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0009 0.0005
Loa Loa (eye worm) hexokinase 0.0294 0.0188 0.0188
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Loa Loa (eye worm) matrixin family protein 0.0191 0.012 0.012
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0054 0.0029 0.0029
Echinococcus multilocularis hexokinase type 2 0.0468 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi CXXC zinc finger family protein 0.0028 0.0012 0.0011
Brugia malayi hexokinase type II 0.0149 0.0092 0.0092
Echinococcus granulosus jumonji domain containing 1A 0.0013 0.0002 0.0002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0016 0.0004 0.0004
Echinococcus multilocularis expressed protein 0.0098 0.0058 0.0058
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.002 0.0007 0.0017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Trypanosoma brucei RNA helicase, putative 0.0155 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0024 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0009 0.0023
Schistosoma mansoni carbonic anhydrase 0.0127 0.0078 0.0077
Brugia malayi Angiotensin-converting enzyme family protein 0.0159 0.0099 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0009 0.0005
Brugia malayi hypothetical protein 0.0013 0.0002 0.0001
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus granulosus carbonic anhydrase II 0.0213 0.0135 0.0135
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0002 0.0001
Onchocerca volvulus 0.0013 0.0002 0.0049
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0054 0.0029 0.0027
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Schistosoma mansoni ankyrin 23/unc44 0.0011 0.0001 0.000000001423
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0058 0.0056
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0054 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Trypanosoma brucei unspecified product 0.0033 0.0015 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.3292 0.2177 0.2175
Echinococcus granulosus expressed protein 0.0098 0.0058 0.0058
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0213 0.0135 0.0133
Echinococcus granulosus hexokinase 0.0468 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0024
Schistosoma mansoni glutathione synthetase 0.4173 0.2761 0.2761
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.4173 0.2761 0.2761
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0004 0.0002
Plasmodium vivax SET domain protein, putative 0.0037 0.0018 0.0016
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0016 0.0004 0.0004
Trypanosoma cruzi squalene synthase, putative 0.0455 0.0295 0.0293
Loa Loa (eye worm) hexokinase 0.0145 0.009 0.009
Echinococcus granulosus lamin 0.0053 0.0029 0.0029
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0013 0.0002 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0004 0.0002
Trypanosoma cruzi phytoene synthase, putative 0.0142 0.0088 0.0085
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0013 0.0002 0.0001
Onchocerca volvulus 0.0013 0.0002 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0029 0.0027
Echinococcus multilocularis dna polymerase kappa 0.0098 0.0058 0.0058
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0013 0.0002 0.0001
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.4173 0.2761 0.276
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) polyprenyl synthetase 1.5085 1 1
Trypanosoma cruzi solanesyl-diphosphate synthase 0.4173 0.2761 0.276
Trypanosoma brucei hexokinase, putative 0.0468 0.0304 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.4173 0.2761 0.2759
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0054 0.0029 0.0027
Brugia malayi hypothetical protein 0.0055 0.003 0.003
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.4173 0.2761 0.9422
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0054 0.0029 0.0029
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0023 0.0021
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0085 0.005 0.005
Echinococcus multilocularis dna polymerase eta 0.0047 0.0025 0.0025
Schistosoma mansoni ap endonuclease 0.0016 0.0004 0.0003
Onchocerca volvulus 0.0294 0.0188 0.6185
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0029 0.0027
Leishmania major GTP-binding protein, putative 0.0021 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.023 0.0146 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Brugia malayi Kelch motif family protein 0.0055 0.003 0.003
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0005
Echinococcus multilocularis inositol monophosphatase 1 0.0194 0.0122 0.0122
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0009 0.0023
Mycobacterium ulcerans hydrolase 0.0063 0.0035 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0018 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.001 0.001
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.002 0.0007 0.0007
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0024 0.0024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Plasmodium vivax importin-beta 2, putative 0.0028 0.0012 0.001
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0024 0.0024
Toxoplasma gondii hexokinase 0.0468 0.0304 0.0302
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus granulosus inositol monophosphatase 0.002 0.0007 0.0007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.023 0.0146 0.0146
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0004 0.0002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.004 0.002 0.0019
Echinococcus granulosus death domain containing protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0005 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Echinococcus multilocularis farnesyl pyrophosphate synthase 1.5085 1 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0013 0.0002 0.0002
Brugia malayi Matrixin family protein 0.0052 0.0028 0.0027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0007 0.0005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0194 0.0122 0.012
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0447 0.029 0.0287
Plasmodium vivax geranylgeranyl pyrophosphate synthase 1.5085 1 1
Onchocerca volvulus Hexokinase homolog 0.0294 0.0188 0.6185
Loa Loa (eye worm) PDE1B protein 0.0054 0.0029 0.0029
Brugia malayi Hexokinase family protein 0.0145 0.009 0.0089
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0009 0.0007
Trypanosoma brucei DNA damage repair protein, putative 0.0015 0.0003 0.0001
Brugia malayi Matrixin family protein 0.0052 0.0028 0.0027
Onchocerca volvulus 0.0053 0.0029 0.0924
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0003 0.0001
Echinococcus granulosus intermediate filament protein 0.0053 0.0029 0.0029
Leishmania major solanesyl-diphosphate synthase, putative 0.4173 0.2761 0.276
Plasmodium falciparum phosphodiesterase gamma, putative 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0046 0.0024 0.0777
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Echinococcus multilocularis JmjC domain containing protein 4 0.0013 0.0002 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0016 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0064
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0025 0.0024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Mycobacterium ulcerans monophosphatase CysQ 0.002 0.0007 0.0004
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0029 0.0027
Echinococcus multilocularis lamin dm0 0.0053 0.0029 0.0029
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.5433 0.3597 0.3597
Plasmodium falciparum importin beta, putative 0.0028 0.0012 0.001
Trypanosoma cruzi farnesyl pyrophosphate synthase 1.5085 1 1
Onchocerca volvulus 0.0468 0.0304 1
Brugia malayi Protein kinase domain containing protein 0.0011 0.0001 0.000000001423
Onchocerca volvulus 0.0013 0.0002 0.0049
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0213 0.0135 0.0134
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Brugia malayi jmjC domain containing protein 0.0013 0.0002 0.0001
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.4428 0.2931 0.2928
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 1.5085 1 1
Brugia malayi Matrixin family protein 0.0052 0.0028 0.0027
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Leishmania major importin beta-1 subunit, putative 0.0023 0.0008 0.0006
Brugia malayi polk-prov protein 0.0065 0.0037 0.0036
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.0004 0.0002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0013 0.0011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0025 0.0025
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0016 0.0004 0.0004
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0085 0.005 0.005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0016 0.0004 0.0004
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.5433 0.3597 0.3597
Echinococcus multilocularis hexokinase 0.0468 0.0304 0.0304
Schistosoma mansoni integrin beta subunit 0.0203 0.0128 0.0128
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0001
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0054 0.0029 0.0029
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0002 0.0002
Brugia malayi Inositol monophosphatase family protein 0.002 0.0007 0.0006
Entamoeba histolytica Ran family GTPase 0.0021 0.0007 0.0018
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.4173 0.2761 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0025
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.3292 0.2177 0.2175
Brugia malayi Inositol-1 0.0194 0.0122 0.0122
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0005 0.0003
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0013 0.0002 0.0000065691
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0447 0.029 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0051 0.0027 0.0866
Brugia malayi jmjC domain containing protein 0.0013 0.0002 0.0001
Mycobacterium tuberculosis Monophosphatase CysQ 0.002 0.0007 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0009 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0008 0.0006
Trypanosoma cruzi polyprenyl synthase, putative 0.5433 0.3597 0.3596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0023 0.0021
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0028 0.0012 0.0011
Onchocerca volvulus 0.0013 0.0002 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0013 0.0002 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0003 0.0001
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 1.5085 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0006
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0142 0.0088 0.0086
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0127 0.0078 0.0077
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0096 0.0057 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0001
Plasmodium vivax DNA repair protein REV1, putative 0.0015 0.0003 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Giardia lamblia Farnesyl diphosphate synthase 1.5085 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0127 0.0078 0.0078
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0213 0.0135 0.0134
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Brugia malayi jmjC domain containing protein 0.0013 0.0002 0.0001
Onchocerca volvulus 0.0013 0.0002 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0142 0.0088 0.0087
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0016 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0018 0.0017
Loa Loa (eye worm) integrin beta-2 0.0353 0.0228 0.0228
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Schistosoma mansoni pcd6 interacting protein-related 0.0013 0.0002 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0016 0.0004 0.0004
Onchocerca volvulus Matrilysin homolog 0.0052 0.0028 0.0894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0023 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Plasmodium falciparum hexokinase 0.0468 0.0304 0.0302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0054 0.0029 0.0027
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0029 0.0029
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.4428 0.2931 1
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.4173 0.2761 0.276
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0009 0.0005
Trichomonas vaginalis rotamase, putative 0.0098 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0052 0.0028 0.0028
Plasmodium falciparum phosphodiesterase delta, putative 0.0054 0.0029 0.0027
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.0117 0.0117
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.3292 0.2177 0.2175
Onchocerca volvulus 0.0023 0.0009 0.0262
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0025 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0001
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0013 0.0002 0.0049
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus Ankyrin 0.0011 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase 0.0064 0.0036 0.0035
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.002 0.0007 0.0005
Onchocerca volvulus 0.0468 0.0304 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0016 0.0004 0.0004
Trichomonas vaginalis inositol monophosphatase, putative 0.002 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0127 0.0078 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0027 0.0027
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0013 0.0002 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Schistosoma mansoni rotamase 0.0098 0.0058 0.0058
Leishmania major DNA polymerase eta, putative 0.0047 0.0025 0.0023
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Loa Loa (eye worm) matrixin family protein 0.0115 0.007 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Trichomonas vaginalis inositol monophosphatase, putative 0.002 0.0007 0.0005
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.003 0.0013 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0329 0.0211 0.0211
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0013 0.0002 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0012 0.0012
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0027 0.0011 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0007 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0002 0.0002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0029 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.055 0.055
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.4173 0.2761 0.2761
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0009 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0007 0.0005
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.5433 0.3597 0.3597
Brugia malayi Hemopexin family protein 0.0073 0.0042 0.0041
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0005
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.0117 0.0117
Onchocerca volvulus 0.0013 0.0002 0.0049
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.002 0.0007 0.0007
Trypanosoma cruzi hexokinase, putative 0.0468 0.0304 0.0302
Trypanosoma brucei farnesyl pyrophosphate synthase 1.5085 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0003 0.0003
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.4173 0.2761 1
Leishmania major myo-inositol-1 phosphatase, putative 0.002 0.0007 0.0005
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0009 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0009 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0004 0.0006
Leishmania major hexokinase, putative 0.0468 0.0304 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0033 0.0033
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0029 0.0028
Toxoplasma gondii exonuclease III APE 0.0016 0.0004 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0001
Echinococcus multilocularis phd:f box containing protein 0.0013 0.0002 0.0002
Echinococcus granulosus carbonic anhydrase 0.0127 0.0078 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0007 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0002 0.0002
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0054 0.0029 0.0029
Echinococcus granulosus lysine specific demethylase 6a 0.0013 0.0002 0.0002
Schistosoma mansoni farnesyl pyrophosphate synthase 1.5085 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.0078 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0018 0.0017
Schistosoma mansoni DNA polymerase eta 0.0047 0.0025 0.0024
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis hexokinase 0.0468 0.0304 0.0304
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0012 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0008 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0029 0.0027
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.002 0.0007 0.0005
Onchocerca volvulus 0.0013 0.0002 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Schistosoma mansoni hypothetical protein 0.0395 0.0256 0.0255
Onchocerca volvulus 0.0052 0.0028 0.0894
Schistosoma mansoni lipoxygenase 0.0039 0.0019 0.0019
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.3292 0.2177 0.2175
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.002 0.0007 0.0005
Echinococcus multilocularis carbonic anhydrase 0.0127 0.0078 0.0078
Echinococcus granulosus lysine specific demethylase 5A 0.0051 0.0027 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0058 0.0056
Leishmania major cathepsin L-like protease 0.0021 0.0007 0.0005
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0029 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0058 0.0056
Brugia malayi Protein-tyrosine phosphatase containing protein 0.023 0.0146 0.0146
Plasmodium vivax hexokinase, putative 0.0468 0.0304 0.0302
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.002 0.0007 0.0005
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0013 0.0002 0.0001
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.5433 0.3597 0.3597
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0085 0.005 0.005
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.4428 0.2931 0.293
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0029 0.0027
Onchocerca volvulus 0.0013 0.0002 0.0049
Schistosoma mansoni hypothetical protein 0.0127 0.0078 0.0077
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.002 0.0007 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0004 0.0004
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 1.5085 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0002 0.0001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0029 0.0029
Echinococcus multilocularis carbonic anhydrase 0.0127 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0027 0.0026
Schistosoma mansoni lamin 0.0053 0.0029 0.0028
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0016 0.0004 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0025 0.0082

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -8 Inhibitory concentration against phosphodiesterase 4 (PDE4) in cytosol of human neutrophils ChEMBL. 12036360
Inhibition (functional) % Percent inhibition of arachidonic acid (AA) formation, induced mouse ear edema after pretreatment at a concentration of 30 umol/kg (po); ND is not determined ChEMBL. 12036360
Inhibition (functional) 0 % Percent inhibition of arachidonic acid (AA) formation, induced mouse ear edema after pretreatment at a concentration of 30 umol/kg (po); ND is not determined ChEMBL. 12036360
Log IC50 (binding) = 8 Inhibitory concentration against phosphodiesterase 4 (PDE4) in cytosol of human neutrophils ChEMBL. 12036360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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