Detailed information for compound 1402060

Basic information

Technical information
  • TDR Targets ID: 1402060
  • Name: 1-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimi dazol-5-yl)-3-(2,5-dimethylphenyl)urea
  • MW: 407.509 | Formula: C23H29N5O2
  • H donors: 2 H acceptors: 2 LogP: 3.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(C)ccc1C)Nc1cc2c(cc1N1CCCCC1)n(c(=O)n2C)C
  • InChi: 1S/C23H29N5O2/c1-15-8-9-16(2)17(12-15)24-22(29)25-18-13-20-21(27(4)23(30)26(20)3)14-19(18)28-10-6-5-7-11-28/h8-9,12-14H,5-7,10-11H2,1-4H3,(H2,24,25,29)
  • InChiKey: HCYRDGALELYHEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[1,3-dimethyl-2-oxo-6-(1-piperidyl)benzimidazol-5-yl]-3-(2,5-dimethylphenyl)urea
  • 1-[1,3-dimethyl-2-oxo-6-(1-piperidyl)-5-benzimidazolyl]-3-(2,5-dimethylphenyl)urea
  • 3-(2,5-dimethylphenyl)-1-(2-keto-1,3-dimethyl-6-piperidino-benzimidazol-5-yl)urea
  • 1-(1,3-dimethyl-2-oxo-6-piperidin-1-yl-benzimidazol-5-yl)-3-(2,5-dimethylphenyl)urea
  • C301-7051
  • NCGC00107597-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus semaphorin 5B 0.0413 0.0671 0.0788
Loa Loa (eye worm) hypothetical protein 0.0115 0.014 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0061 0.0045 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0085 0.0087 0.0275
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0045 0.0043
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0085 0.0087 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Echinococcus multilocularis tyrosine protein kinase 0.0061 0.0045 0.0039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Trypanosoma cruzi PH domain containing protein, putative 0.0084 0.0085 0.4999
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0107 0.0125 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0181 0.0258 0.1604
Brugia malayi hypothetical protein 0.0061 0.0045 0.0032
Schistosoma mansoni oxysterol-binding protein 1 0.0084 0.0085 0.0065
Echinococcus granulosus plexin a4 0.1155 0.1993 0.237
Echinococcus multilocularis Regulator of G protein signaling 20 0.0916 0.1567 0.1861
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Brugia malayi Protein kinase domain containing protein 0.0319 0.0504 0.0492
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Plasmodium vivax PH domain containing protein 0.0084 0.0085 0.4999
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Schistosoma mansoni hypothetical protein 0.0181 0.0258 0.0238
Echinococcus granulosus tyrosine protein kinase Src42A 0.0061 0.0045 0.0039
Echinococcus granulosus tyrosine kinase 0.0061 0.0045 0.0039
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) serine/threonine protein kinase 0.0061 0.0045 0.0043
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0061 0.0045 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0087 0.0508
Brugia malayi Furin-like cysteine rich region family protein 0.0061 0.0045 0.0032
Leishmania major folate/biopterin transporter, putative 0.0107 0.0125 1
Echinococcus multilocularis oxysterol binding protein 1 0.0084 0.0085 0.0087
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0085 0.0087 0.522
Onchocerca volvulus outspread protein homolog 0.0084 0.0085 0.0511
Entamoeba histolytica hypothetical protein 0.0084 0.0085 0.0264
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0916 0.1567 0.1861
Leishmania major hypothetical protein, conserved 0.0084 0.0085 0.4999
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Brugia malayi PXA domain containing protein 0.0916 0.1567 0.1557
Trypanosoma brucei aurora B kinase 0.0085 0.0087 0.522
Echinococcus granulosus raf serine:threonine protein kinase 0.0061 0.0045 0.0039
Echinococcus multilocularis natriuretic peptide receptor 1 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0916 0.1567 1
Brugia malayi hypothetical protein 0.0413 0.0671 0.0659
Echinococcus granulosus ephrin type A receptor 4 A 0.0061 0.0045 0.0039
Brugia malayi hypothetical protein 0.0916 0.1567 0.1557
Entamoeba histolytica hypothetical protein 0.0916 0.1567 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0061 0.0045 0.0032
Brugia malayi hypothetical protein 0.0413 0.0671 0.0659
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0181 0.0258 0.1604
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0974 0.1671 0.1669
Echinococcus multilocularis tyrosine protein kinase Blk 0.0061 0.0045 0.0039
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0045 0.0043
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0061 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase pr2 0.0061 0.0045 0.0039
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Schistosoma mansoni fibrocystin l 0.0181 0.0258 0.0238
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0084 0.0085 0.4999
Loa Loa (eye worm) PXA domain-containing protein 0.0916 0.1567 0.1565
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Brugia malayi Plekhf2 protein 0.0084 0.0085 0.0073
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus granulosus retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Leishmania major protein kinase, putative 0.0107 0.0125 1
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Onchocerca volvulus 0.0061 0.0045 0.027
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4732 0.8368 0.8368
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0084 0.0085 0.0087
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.0085 0.0083
Echinococcus multilocularis G protein coupled receptor kinase 6 0.4732 0.8368 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0061 0.0045 0.0043
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0084 0.0085 0.4999
Entamoeba histolytica hypothetical protein 0.0107 0.0125 0.0528
Brugia malayi hypothetical protein 0.0061 0.0045 0.0032
Brugia malayi bone morphogenetic protein type 1 receptor 0.0061 0.0045 0.0032
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0115 0.014 0.0137
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0084 0.0085 0.0065
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0061 0.0045 0.0039
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0061 0.0045 0.0025
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Schistosoma mansoni hypothetical protein 0.0084 0.0085 0.0065
Echinococcus multilocularis rac serine:threonine kinase 0.0107 0.0125 0.0135
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Echinococcus granulosus twitchin 0.0137 0.018 0.02
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Entamoeba histolytica hypothetical protein 0.0181 0.0258 0.1398
Echinococcus granulosus aurora kinase A 0.0085 0.0087 0.0089
Onchocerca volvulus 0.0061 0.0045 0.027
Loa Loa (eye worm) hypothetical protein 0.012 0.0149 0.0147
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0084 0.0085 0.0073
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Schistosoma mansoni zinc finger protein 0.0084 0.0085 0.0065
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0061 0.0045 0.0032
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0181 0.0258 0.1604
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Trypanosoma cruzi NIMA-related kinase, putative 0.0107 0.0125 1
Onchocerca volvulus Protein melted homolog 0.0084 0.0085 0.0511
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0045 0.0025
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0107 0.0125 1
Loa Loa (eye worm) SRC-1 0.0061 0.0045 0.0043
Echinococcus granulosus natriuretic peptide receptor 1 0.0061 0.0045 0.0039
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0085 0.0065
Brugia malayi PXA domain containing protein 0.0916 0.1567 0.1557
Echinococcus granulosus kinase suppressor of Ras 1 0.0061 0.0045 0.0039
Plasmodium falciparum PH domain-containing protein, putative 0.0084 0.0085 0.4999
Brugia malayi serine/threonine protein kinase 6 0.0085 0.0087 0.0074
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0115 0.014 0.012
Loa Loa (eye worm) TK/EGFR protein kinase 0.0061 0.0045 0.0043
Brugia malayi Regulator of G protein signaling domain containing protein 0.0916 0.1567 0.1557
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0067 0.0055 0.005
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0085 0.0073
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0085 0.0087 0.0089
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0107 0.0125 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0087 0.0508
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Onchocerca volvulus 0.0286 0.0445 0.2665
Echinococcus multilocularis aurora kinase A 0.0085 0.0087 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0084 0.0085 0.0497
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0107 0.0125 0.0755
Schistosoma mansoni zinc finger protein 0.0084 0.0085 0.0065
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0084 0.0085 0.0087
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Entamoeba histolytica PH domain containing protein kinase, putative 0.0107 0.0125 0.0528
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Brugia malayi Pre-SET motif family protein 0.0251 0.0383 0.0371
Trichomonas vaginalis alpha chimerin, putative 0.0084 0.0085 0.0497
Loa Loa (eye worm) TK/DDR protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus multilocularis tyrosine protein kinase Srms 0.0061 0.0045 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0107 0.0125 0.0528
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus multilocularis protein tyrosine kinase 0.0061 0.0045 0.0039
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0061 0.0045 0.0039
Trichomonas vaginalis hypothetical protein 0.0084 0.0085 0.0497
Echinococcus granulosus calcium dependent secretion activator 1 0.0084 0.0085 0.0087
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0916 0.1567 0.1861
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0085 0.0087 0.0275
Entamoeba histolytica p21-activated kinase 0.0107 0.0125 0.0528
Trypanosoma brucei PH domain containing protein, putative 0.0084 0.0085 0.4999
Echinococcus granulosus regulator of G protein signaling 7 0.0916 0.1567 0.1861
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Brugia malayi SRC-1 0.0061 0.0045 0.0032
Onchocerca volvulus 0.0061 0.0045 0.027
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Schistosoma mansoni serine/threonine protein kinase 0.4329 0.765 0.7645
Echinococcus multilocularis Pleckstrin y 0.0084 0.0085 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0916 0.1567 0.1551
Trichomonas vaginalis centaurin gamma, putative 0.0084 0.0085 0.0497
Echinococcus multilocularis Rho GTPase activating protein 24 0.0084 0.0085 0.0087
Echinococcus multilocularis protein KINase family member (kin 25) 0.0061 0.0045 0.0039
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0061 0.0045 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.0149 0.0137
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Schistosoma mansoni regulator of G protein signaling 0.0916 0.1567 0.1551
Echinococcus granulosus protein tyrosine kinase 0.0061 0.0045 0.0039
Loa Loa (eye worm) cytohesin 3 0.0084 0.0085 0.0083
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Brugia malayi protein-tyrosine kinase 0.0061 0.0045 0.0032
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0084 0.0085 0.0087
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Loa Loa (eye worm) hypothetical protein 0.0181 0.0258 0.0255
Echinococcus granulosus c src tyrosine kinase 0.0061 0.0045 0.0039
Echinococcus granulosus beta-adrenergic receptor kinase 0.4329 0.765 0.9141
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Echinococcus granulosus retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Entamoeba histolytica cell surface protease gp63, putative 0.0181 0.0258 0.1398
Trichomonas vaginalis centaurin/arf, putative 0.0084 0.0085 0.0497
Echinococcus multilocularis tyrosine protein kinase Abl 0.0061 0.0045 0.0039
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0084 0.0085 0.0083
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0181 0.0258 0.1604
Trichomonas vaginalis centaurin/arf, putative 0.0084 0.0085 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0916 0.1567 1
Echinococcus granulosus protein kinase 0.0061 0.0045 0.0039
Echinococcus multilocularis tyrosine protein kinase HCK 0.0061 0.0045 0.0039
Echinococcus multilocularis Oxysterol binding protein 11 0.0084 0.0085 0.0087
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Trypanosoma cruzi NIMA-related kinase, putative 0.0107 0.0125 1
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0107 0.0125 1
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Echinococcus granulosus defective proboscis extension response 0.0115 0.014 0.0152
Echinococcus multilocularis myotubularin protein 13 0.0084 0.0085 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0061 0.0045 0.0039
Onchocerca volvulus 0.0061 0.0045 0.027
Schistosoma mansoni serine/threonine protein kinase 0.4329 0.765 0.7645
Schistosoma mansoni tyrosine protein kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus granulosus pleckstrin y domain containing family A 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis Immunoglobulin 0.0115 0.014 0.0152
Echinococcus multilocularis oxysterol binding protein 3 0.0084 0.0085 0.0087
Entamoeba histolytica hypothetical protein 0.0084 0.0085 0.0264
Brugia malayi hypothetical protein 0.0061 0.0045 0.0032
Echinococcus multilocularis Immunoglobulin 0.0115 0.014 0.0152
Onchocerca volvulus 0.0061 0.0045 0.027
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0107 0.0125 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0061 0.0045 0.0039
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0107 0.0125 1
Onchocerca volvulus 0.0061 0.0045 0.027
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0045 0.0039
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Trichomonas vaginalis protein transport protein sec7, putative 0.0084 0.0085 0.0497
Onchocerca volvulus 0.0974 0.1671 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0067 0.0055 0.005
Echinococcus multilocularis transfer RNA-Thr 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0115 0.014 0.0137
Brugia malayi Protein kinase domain containing protein 0.0107 0.0125 0.0113
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0084 0.0085 0.0511
Echinococcus multilocularis c src tyrosine kinase 0.0061 0.0045 0.0039
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0084 0.0085 0.0087
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Toxoplasma gondii aurora kinase 0.0085 0.0087 0.522
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Schistosoma mansoni myotubularin-related protein 0.0084 0.0085 0.0065
Trypanosoma cruzi PH domain containing protein, putative 0.0084 0.0085 0.4999
Echinococcus granulosus retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Loa Loa (eye worm) TK/RYK protein kinase 0.0061 0.0045 0.0043
Entamoeba histolytica PH domain containing protein kinase, putative 0.0107 0.0125 0.0528
Onchocerca volvulus 0.0084 0.0085 0.0511
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Entamoeba histolytica protein kinase, putative 0.0085 0.0087 0.0275
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0084 0.0085 0.0065
Schistosoma mansoni protein kinase 0.0084 0.0085 0.0065
Loa Loa (eye worm) TK/Met protein kinase 0.0061 0.0045 0.0043
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0061 0.0045 0.0032
Schistosoma mansoni protein kinase 0.0084 0.0085 0.0065
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi Syntrophin-1 0.0084 0.0085 0.0073
Schistosoma mansoni syntrophin 0.0084 0.0085 0.0065
Schistosoma mansoni protein tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus Pleckstrin y 0.0084 0.0085 0.0087
Entamoeba histolytica hypothetical protein 0.0084 0.0085 0.0264
Onchocerca volvulus Putative zinc finger protein 0.0084 0.0085 0.0511
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0061 0.0045 0.0039
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Schistosoma mansoni hypothetical protein 0.0084 0.0085 0.0065
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0061 0.0045 0.027
Onchocerca volvulus 0.0084 0.0085 0.0511
Loa Loa (eye worm) hypothetical protein 0.0413 0.0671 0.0669
Loa Loa (eye worm) hypothetical protein 0.012 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0181 0.0258 0.0255
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0061 0.0045 0.0039
Brugia malayi serine/threonine kinase 12 0.0085 0.0087 0.0074
Loa Loa (eye worm) hypothetical protein 0.0413 0.0671 0.0669
Echinococcus multilocularis GRB2 associated binding protein 3 0.0084 0.0085 0.0087
Brugia malayi Dynamin 0.0084 0.0085 0.0073
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Echinococcus granulosus GRB2 associated binding protein 3 0.0084 0.0085 0.0087
Echinococcus multilocularis regulator of G protein signaling 3 0.0916 0.1567 0.1861
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Schistosoma mansoni goodpasture antigen-binding protein 0.0084 0.0085 0.0065
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0061 0.0045 0.0043
Onchocerca volvulus 0.0061 0.0045 0.027
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis pdz domain containing protein 0.0084 0.0085 0.0087
Echinococcus multilocularis neuroglian 0.0115 0.014 0.0152
Schistosoma mansoni oxysterol-binding protein 1 0.0084 0.0085 0.0065
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0383 0.0381
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus beta 1 syntrophin 0.0084 0.0085 0.0087
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0084 0.0085 0.0087
Entamoeba histolytica PH domain containing protein kinase, putative 0.0107 0.0125 0.0528
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Leishmania major protein kinase, putative 0.0085 0.0087 0.522
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Loa Loa (eye worm) hypothetical protein 0.0181 0.0258 0.0255
Echinococcus multilocularis tyrosine protein kinase pr2 0.0061 0.0045 0.0039
Schistosoma mansoni ephrin receptor 0.0067 0.0055 0.0035
Echinococcus granulosus tyrosine protein kinase csk 0.0061 0.0045 0.0039
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0084 0.0085 0.0511
Echinococcus granulosus myotubularin protein 13 0.0084 0.0085 0.0087
Echinococcus multilocularis integrin linked protein kinase 0.0061 0.0045 0.0039
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0061 0.0045 0.0039
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Echinococcus multilocularis axis inhibition protein axin 0.0916 0.1567 0.1861
Schistosoma mansoni semaphorin 5-related 0.0413 0.0671 0.0653
Echinococcus multilocularis expressed protein 0.0916 0.1567 0.1861
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0045 0.0043
Entamoeba histolytica PH domain containing protein 0.0084 0.0085 0.0264
Loa Loa (eye worm) TK/ALK protein kinase 0.0319 0.0504 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0084 0.0085 0.0087
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.4732 0.8368 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Onchocerca volvulus 0.0084 0.0085 0.0511
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0013 0.001
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0061 0.0045 0.0039
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0061 0.0045 0.0039
Loa Loa (eye worm) RGS-3 protein 0.0916 0.1567 0.1565
Echinococcus multilocularis oxysterol binding protein 9 0.0084 0.0085 0.0087
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0107 0.0125 1
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0084 0.0085 0.0087
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus G protein coupled receptor kinase 1 0.3414 0.6018 0.7188
Echinococcus multilocularis hypothetical protein 0.0413 0.0671 0.0788
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Loa Loa (eye worm) AUR protein kinase 0.0085 0.0087 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Brugia malayi regulator of G-protein signaling rgs-7 0.0916 0.1567 0.1557
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.0045 0.0039
Entamoeba histolytica tyrosin kinase, putative 0.0242 0.0367 0.2117
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) oxysterol binding protein 0.0084 0.0085 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0061 0.0045 0.0032
Echinococcus multilocularis DCC interacting protein 13 beta 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus multilocularis dynamin 1 0.0084 0.0085 0.0087
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0045 0.0043
Brugia malayi Tyrosine-protein kinase abl-1 0.0061 0.0045 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0916 0.1567 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi Probable exocyst complex component Sec5 0.0181 0.0258 0.0245
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0084 0.0085 0.5001
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Brugia malayi Cytohesin 3 0.0084 0.0085 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0084 0.0085 0.0497
Loa Loa (eye worm) syntrophin-1 0.0084 0.0085 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Schistosoma mansoni hypothetical protein 0.0084 0.0085 0.0065
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0107 0.0125 1
Loa Loa (eye worm) AUR protein kinase 0.0085 0.0087 0.0084
Echinococcus multilocularis roundabout 2 0.012 0.0149 0.0163
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0115 0.014 0.012
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0115 0.014 0.0137
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Echinococcus granulosus pdz domain containing protein 0.0084 0.0085 0.0087
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Brugia malayi DNA-binding protein LAG-1 0.0181 0.0258 0.0245
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0107 0.0125 1
Entamoeba histolytica hypothetical protein 0.0181 0.0258 0.1398
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0085 0.0073
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0061 0.0045 0.0039
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Toxoplasma gondii phosphatidylinositol transfer protein 0.0084 0.0085 0.4999
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0107 0.0125 1
Entamoeba histolytica ankyrin repeat protein 0.0061 0.0045 0.000000017675
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Echinococcus multilocularis regulator of G protein signaling 0.0916 0.1567 0.1861
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0087 0.0067
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0085 0.4999
Loa Loa (eye worm) rho-GTPase-activating 0.0084 0.0085 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0085 0.4999
Entamoeba histolytica protein kinase domain containing protein 0.0242 0.0367 0.2117
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0061 0.0045 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0061 0.0045 0.0025
Echinococcus multilocularis activated cdc42 kinase 1 0.0061 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase csk 0.0061 0.0045 0.0039
Onchocerca volvulus 0.0061 0.0045 0.027
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0061 0.0045 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0107 0.0125 0.0528
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis tyrosine kinase 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Echinococcus granulosus serine/threonine protein kinase 0.0107 0.0125 0.0135
Brugia malayi TBC domain containing protein 0.0084 0.0085 0.0073
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0061 0.0045 0.0039
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0087 0.0508
Loa Loa (eye worm) AUR protein kinase 0.0085 0.0087 0.0084
Entamoeba histolytica hypothetical protein 0.0084 0.0085 0.0264
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Echinococcus granulosus Pleckstrin y 0.0084 0.0085 0.0087
Plasmodium falciparum oxysterol-binding protein, putative 0.0084 0.0085 0.4999
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Onchocerca volvulus 0.0061 0.0045 0.027
Echinococcus multilocularis regulator of G protein signaling 7 0.0916 0.1567 0.1861
Trypanosoma cruzi PH domain containing protein, putative 0.0084 0.0085 0.4999
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0045 0.0039
Schistosoma mansoni vav2 0.0084 0.0085 0.0065
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus activated cdc42 kinase 1 0.0061 0.0045 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0061 0.0045 0.0032
Brugia malayi hypothetical protein 0.012 0.0149 0.0137
Loa Loa (eye worm) uncoordinated protein 104 0.0084 0.0085 0.0083
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus multilocularis calcium dependent secretion activator 1 0.0084 0.0085 0.0087
Loa Loa (eye worm) TK/ABL protein kinase 0.0061 0.0045 0.0043
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0084 0.0085 0.0264
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Onchocerca volvulus 0.0084 0.0085 0.0511
Toxoplasma gondii hypothetical protein 0.0084 0.0085 0.4999
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0084 0.0085 0.0087
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0084 0.0085 0.0083
Schistosoma mansoni dynamin 0.0084 0.0085 0.0065
Loa Loa (eye worm) hypothetical protein 0.0115 0.014 0.0137
Echinococcus multilocularis heat shock protein 70 0.0061 0.0045 0.0039
Schistosoma mansoni rho gtpase activating protein 0.0084 0.0085 0.0065
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0061 0.0045 0.0043
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0107 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Brugia malayi Regulator of G protein signaling domain containing protein 0.0916 0.1567 0.1557
Loa Loa (eye worm) hypothetical protein 0.0227 0.0339 0.0337
Echinococcus granulosus fibroblast growth factor receptor 4 0.0061 0.0045 0.0039
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0084 0.0085 0.4999
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0085 0.4999
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0084 0.0085 0.0087
Echinococcus granulosus tyrosine protein kinase Lyn 0.0084 0.0085 0.0087
Onchocerca volvulus 0.0061 0.0045 0.027
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0061 0.0045 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0916 0.1567 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Loa Loa (eye worm) hypothetical protein 0.0916 0.1567 0.1565
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0107 0.0125 1
Schistosoma mansoni hypothetical protein 0.0413 0.0671 0.0653
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0916 0.1567 0.1565
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Schistosoma mansoni hypothetical protein 0.0084 0.0085 0.0065
Giardia lamblia Kinase, NEK 0.0061 0.0045 0.00000064176
Echinococcus multilocularis transcription factor collier 0.0181 0.0258 0.0293
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0061 0.0045 0.0032
Entamoeba histolytica hypothetical protein, conserved 0.0084 0.0085 0.0264
Echinococcus multilocularis activin receptor type 0.0084 0.0085 0.0087
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Echinococcus multilocularis regulator of G protein signaling 3 0.0916 0.1567 0.1861
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Echinococcus multilocularis beta 1 syntrophin 0.0084 0.0085 0.0087
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0084 0.0085 0.5001
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Entamoeba histolytica hypothetical protein 0.0107 0.0125 0.0528
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Brugia malayi regulator of G-protein signaling egl-10 0.0916 0.1567 0.1557
Loa Loa (eye worm) TK/ROR protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0916 0.1567 1
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0107 0.0125 0.0755
Brugia malayi Sema domain containing protein 0.0413 0.0671 0.0659
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0085 0.0087 0.0089
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0916 0.1567 0.1551
Onchocerca volvulus 0.0061 0.0045 0.027
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis tyrosine protein kinase shark 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0176 0.0249 0.0247
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Onchocerca volvulus 0.0061 0.0045 0.027
Brugia malayi hypothetical protein 0.0084 0.0085 0.0073
Toxoplasma gondii AtPH1 family protein 0.0084 0.0085 0.4999
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0084 0.0085 0.0264
Trypanosoma brucei rac serine-threonine kinase, putative 0.0107 0.0125 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1421 0.1403
Trichomonas vaginalis conserved hypothetical protein 0.0916 0.1567 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0084 0.0085 0.0065
Schistosoma mansoni centaurin alpha 0.0084 0.0085 0.0065
Leishmania major hypothetical protein, conserved 0.0084 0.0085 0.4999
Trichomonas vaginalis protein transport protein sec7, putative 0.0084 0.0085 0.0497
Trichomonas vaginalis STE family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0561 0.0936 0.0933
Brugia malayi ephrin receptor 1 precursor 0.0061 0.0045 0.0032
Echinococcus granulosus regulator of G protein signaling 3 0.0916 0.1567 0.1861
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Echinococcus multilocularis kinase suppressor of Ras 1 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Onchocerca volvulus 0.0061 0.0045 0.027
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus tyrosine protein kinase Src64B 0.0061 0.0045 0.0039
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0084 0.0085 0.5001
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) protein kinase domain-containing protein 0.0061 0.0045 0.0043
Trypanosoma cruzi Protein kinase B 0.0107 0.0125 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Echinococcus granulosus transcription factor collier 0.0181 0.0258 0.0293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0249 0.0237
Trypanosoma cruzi aurora B kinase, putative 0.0085 0.0087 0.522
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0087 0.0508
Brugia malayi Oxysterol binding protein 0.0084 0.0085 0.0073
Entamoeba histolytica protein kinase, putative 0.0061 0.0045 0.000000017675
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Echinococcus granulosus Immunoglobulin 0.0115 0.014 0.0152
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus cytohesin 1 0.0084 0.0085 0.0087
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0084 0.0085 0.4999
Loa Loa (eye worm) plexin A 0.1155 0.1993 0.1991
Echinococcus granulosus tyrosine protein kinase Srms 0.0061 0.0045 0.0039
Trichomonas vaginalis kinesin light chain, putative 0.0084 0.0085 0.0497
Entamoeba histolytica hypothetical protein 0.0181 0.0258 0.1398
Echinococcus granulosus Regulator of G protein signaling 20 0.0916 0.1567 0.1861
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0061 0.0045 0.0025
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Echinococcus granulosus oxysterol binding protein 1 0.0084 0.0085 0.0087
Echinococcus granulosus integrin linked protein kinase 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.012 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Schistosoma mansoni hypothetical protein 0.0561 0.0936 0.0917
Schistosoma mansoni regulator of G protein signaling 0.0916 0.1567 0.1551
Loa Loa (eye worm) hypothetical protein 0.0413 0.0671 0.0669
Echinococcus granulosus neuroglian 0.0115 0.014 0.0152
Entamoeba histolytica protein kinase , putative 0.0085 0.0087 0.0275
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0916 0.1567 0.1565
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Toxoplasma gondii Oxysterol-binding protein 0.0084 0.0085 0.4999
Schistosoma mansoni serine/threonine-protein kinase 0.0107 0.0125 0.0106
Onchocerca volvulus 0.0413 0.0671 0.4017
Echinococcus multilocularis regulator of G protein signaling 7 0.0916 0.1567 0.1861
Trichomonas vaginalis centaurin beta, putative 0.0084 0.0085 0.0497
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Echinococcus multilocularis beta adrenergic receptor kinase 0.4329 0.765 0.9141
Echinococcus granulosus Rho GTPase activating protein 24 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3414 0.6018 0.7188
Echinococcus granulosus semaphorin 1A 0.0413 0.0671 0.0788
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Schistosoma mansoni plexin 0.0561 0.0936 0.0917
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Echinococcus granulosus oxysterol binding protein 9 0.0084 0.0085 0.0087
Brugia malayi hypothetical protein 0.0916 0.1567 0.1557
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0061 0.0045 0.0039
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0061 0.0045 0.0039
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0084 0.0085 0.0087
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0045 0.0039
Loa Loa (eye worm) PH domain-containing protein 0.0084 0.0085 0.0083
Schistosoma mansoni hypothetical protein 0.0181 0.0258 0.0238
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0045 0.0025
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0084 0.0085 0.0087
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus regulator of G protein signaling 7 0.0916 0.1567 0.1861
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0916 0.1567 0.1565
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Echinococcus multilocularis Ras associated and pleckstrin y 0.0084 0.0085 0.0087
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0084 0.0085 0.0264
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) AGC/AKT protein kinase 0.0107 0.0125 0.0123
Brugia malayi Receptor family ligand binding region containing protein 0.0061 0.0045 0.0032
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1421 0.1685
Echinococcus granulosus receptor type guanylyl cyclase 0.0061 0.0045 0.0039
Schistosoma mansoni axis inhibition protein axin 0.0916 0.1567 0.1551
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0115 0.014 0.0152
Brugia malayi integrin-linked kinase 0.0061 0.0045 0.0032
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Entamoeba histolytica hypothetical protein 0.0181 0.0258 0.1398
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis FL cytokine receptor 0.0061 0.0045 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.0085 0.0264
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0061 0.0045 0.0025
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Schistosoma mansoni plexin 0.0974 0.1671 0.1655
Schistosoma mansoni serine/threonine-protein kinase 0.0107 0.0125 0.0106
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Brugia malayi Dynamin 0.0084 0.0085 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0084 0.0085 0.0087
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0916 0.1567 0.1551
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0061 0.0045 0.024
Brugia malayi Oxysterol-binding protein 0.0084 0.0085 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0045 0.0025
Echinococcus multilocularis semaphorin 5B 0.0413 0.0671 0.0788
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0084 0.0085 0.0087
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0084 0.0085 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Brugia malayi Guanylyl cyclase protein 23 0.0061 0.0045 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Loa Loa (eye worm) hypothetical protein 0.0413 0.0671 0.0669
Echinococcus multilocularis Pleckstrin y 0.0084 0.0085 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0916 0.1567 0.1551
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.0045 0.0039
Schistosoma mansoni cell adhesion molecule 0.012 0.0149 0.013
Echinococcus granulosus DCC interacting protein 13 beta 0.0084 0.0085 0.0087
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.014 0.0152
Onchocerca volvulus 0.0061 0.0045 0.027
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trypanosoma cruzi PH domain containing protein, putative 0.0084 0.0085 0.4999
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/EPH protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Echinococcus multilocularis axis inhibition protein axin 0.0916 0.1567 0.1861
Plasmodium falciparum protein kinase, putative 0.0084 0.0085 0.5001
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0061 0.0045 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0045 0.0043
Schistosoma mansoni z-protein (S1r protein) 0.0916 0.1567 0.1551
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.4329 0.765 0.765
Entamoeba histolytica PH domain containing protein 0.0084 0.0085 0.0264
Trypanosoma brucei protein kinase, putative 0.0084 0.0085 0.5001
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Trichomonas vaginalis centaurin alpha, putative 0.0084 0.0085 0.0497
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Entamoeba histolytica ARF GTPase activating protein, putative 0.0084 0.0085 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Loa Loa (eye worm) sema domain-containing protein 0.0413 0.0671 0.0669
Schistosoma mansoni protein kinase 0.0085 0.0087 0.0067
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0107 0.0125 1
Onchocerca volvulus 0.0084 0.0085 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0084 0.0085 0.4999
Echinococcus multilocularis receptor type guanylyl cyclase 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi Pleckstrin Homology Domain 0.0084 0.0085 0.0073
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Brugia malayi C-terminal src kinase protein 1 0.0061 0.0045 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis tyrosine kinase 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Leishmania major protein kinase, putative 0.0107 0.0125 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0107 0.0125 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0916 0.1567 1
Entamoeba histolytica PH domain containing protein 0.0084 0.0085 0.0264
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0061 0.0045 0.024
Loa Loa (eye worm) TK/INSR protein kinase 0.0061 0.0045 0.0043
Echinococcus granulosus expressed protein 0.0916 0.1567 0.1861
Echinococcus granulosus activated cdc42 kinase 1 0.0061 0.0045 0.0039
Echinococcus granulosus activin receptor type 0.0084 0.0085 0.0087
Echinococcus multilocularis ephrin type A receptor 4 A 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Giardia lamblia Protein 21.1 0.0061 0.0045 0.00000064176
Brugia malayi probable spectrin beta chain 0.0084 0.0085 0.0073
Loa Loa (eye worm) sema domain-containing protein 0.0413 0.0671 0.0669
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0061 0.0045 0.0039
Entamoeba histolytica hypothetical protein 0.0916 0.1567 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0061 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0916 0.1567 0.1565
Echinococcus granulosus insulin receptor 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Loa Loa (eye worm) hypothetical protein 0.0916 0.1567 0.1565
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0084 0.0085 0.0497
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Loa Loa (eye worm) TK/CSK protein kinase 0.0061 0.0045 0.0043
Toxoplasma gondii protein kinase domain-containing protein 0.0107 0.0125 1
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus multilocularis insulin receptor 0.0061 0.0045 0.0039
Schistosoma mansoni goodpasture antigen-binding protein 0.0084 0.0085 0.0065
Leishmania major serine/threonine-protein kinase a, putative 0.0107 0.0125 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Entamoeba histolytica hypothetical protein 0.0916 0.1567 1
Brugia malayi IPT/TIG domain containing protein 0.0181 0.0258 0.0245
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Brugia malayi Raf kinase 0.0061 0.0045 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0061 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Echinococcus granulosus tyrosine protein kinase csk 0.0061 0.0045 0.0039
Schistosoma mansoni vesicular amine transporter 0.0117 0.0145 0.0125
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus tyrosine protein kinase HCK 0.0061 0.0045 0.0039
Schistosoma mansoni hypothetical protein 0.0413 0.0671 0.0653
Brugia malayi Tyrosine-protein kinase PR2 0.0061 0.0045 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0045 0.0025
Echinococcus multilocularis cytohesin 1 0.0084 0.0085 0.0087
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Entamoeba histolytica hypothetical protein 0.0084 0.0085 0.0264
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0084 0.0085 0.5001
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Echinococcus granulosus axis inhibition protein axin 0.0916 0.1567 0.1861
Brugia malayi MAX-1A 0.0084 0.0085 0.0073
Brugia malayi Fibronectin type III domain containing protein 0.012 0.0149 0.0137
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.0045 0.0039
Leishmania major protein kinase, putative 0.0084 0.0085 0.5001
Loa Loa (eye worm) hypothetical protein 0.0115 0.014 0.0137
Entamoeba histolytica protein kinase, putative 0.0085 0.0087 0.0275
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0043
Brugia malayi A-kinase anchor protein 10, precursor 0.0916 0.1567 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Trichomonas vaginalis protein tyrosine kinase, putative 0.0061 0.0045 0.024
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0084 0.0085 0.4999
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0061 0.0045 0.024
Echinococcus multilocularis protein kinase 0.0061 0.0045 0.0039
Brugia malayi Cadps2 protein 0.0084 0.0085 0.0073
Echinococcus granulosus tyrosine protein kinase Blk 0.0061 0.0045 0.0039
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Brugia malayi Sema domain containing protein 0.0413 0.0671 0.0659
Echinococcus granulosus tyrosine protein kinase 0.0061 0.0045 0.0039
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0107 0.0125 1
Echinococcus granulosus axis inhibition protein axin 0.0916 0.1567 0.1861
Trypanosoma brucei protein kinase, putative 0.0107 0.0125 1
Onchocerca volvulus 0.0061 0.0045 0.027
Echinococcus granulosus oxysterol binding protein 3 0.0084 0.0085 0.0087
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus tyrosine protein kinase ABL1 0.0061 0.0045 0.0039
Echinococcus multilocularis plexin a4 0.1155 0.1993 0.237
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Echinococcus multilocularis exocyst complex component 2 0.0181 0.0258 0.0293
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0916 0.1567 0.1565
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.0087 0.0275
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Brugia malayi Plexin repeat family protein 0.0974 0.1671 0.166
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0084 0.0085 0.0497
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0084 0.0085 0.0065
Brugia malayi Uncoordinated protein 104 0.0084 0.0085 0.0073
Entamoeba histolytica protein kinase, putative 0.0107 0.0125 0.0528
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0181 0.0258 0.1604
Brugia malayi SH2 domain containing protein 0.0061 0.0045 0.0032
Echinococcus granulosus tyrosine kinase 0.0061 0.0045 0.0039
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0084 0.0085 0.0264
Loa Loa (eye worm) TK/FAK protein kinase 0.0061 0.0045 0.0043
Schistosoma mansoni serine/threonine RGC 0.0061 0.0045 0.0025
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.4732 0.8368 0.8366
Echinococcus multilocularis Pleckstrin y 0.0084 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Onchocerca volvulus 0.0084 0.0085 0.0511
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0084 0.0085 0.0264
Schistosoma mansoni nephrin 0.012 0.0149 0.013
Echinococcus multilocularis protein kinase 0.0061 0.0045 0.0039
Brugia malayi serine/threonine-protein kinase 6 0.0085 0.0087 0.0074
Echinococcus multilocularis pleckstrin y domain containing family A 0.0084 0.0085 0.0087
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Echinococcus granulosus dynamin 1 0.0084 0.0085 0.0087
Loa Loa (eye worm) Plekhf2 protein 0.0084 0.0085 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Schistosoma mansoni axis inhibition protein axin 0.0916 0.1567 0.1551
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Brugia malayi SH2 domain containing protein 0.0061 0.0045 0.0032
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0916 0.1567 1
Loa Loa (eye worm) hypothetical protein 0.0413 0.0671 0.0669
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0107 0.0125 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Entamoeba histolytica protein kinase, putative 0.0061 0.0045 0.000000017675
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Schistosoma mansoni ephrin receptor 0.0061 0.0045 0.0025
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0045 0.0039
Echinococcus granulosus roundabout 2 0.012 0.0149 0.0163
Schistosoma mansoni hypothetical protein 0.0061 0.0045 0.0025
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0061 0.0045 0.0039
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0084 0.0085 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Plasmodium falciparum serine/threonine protein kinase, putative 0.0085 0.0087 0.522
Schistosoma mansoni protein kinase 0.0061 0.0045 0.0025
Echinococcus granulosus exocyst complex component 2 0.0181 0.0258 0.0293
Echinococcus granulosus tyrosine kinase 0.0061 0.0045 0.0039
Brugia malayi plexin A 0.1155 0.1993 0.1983
Onchocerca volvulus 0.0084 0.0085 0.0511
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Echinococcus granulosus tyrosine protein kinase shark 0.0061 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1421 0.1685
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0258 0.1604
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Schistosoma mansoni protein kinase 0.0084 0.0085 0.0065
Brugia malayi PH domain containing protein 0.0084 0.0085 0.0073
Schistosoma mansoni dynamin 0.0084 0.0085 0.0065
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0084 0.0085 0.0497
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0084 0.0085 0.0264
Loa Loa (eye worm) TK protein kinase 0.0061 0.0045 0.0043
Onchocerca volvulus Tyrosine kinase homolog 0.0061 0.0045 0.027
Giardia lamblia Aurora kinase 0.0085 0.0087 1
Toxoplasma gondii hypothetical protein 0.0084 0.0085 0.4999
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0125 0.0755
Schistosoma mansoni hypothetical protein 0.0084 0.0085 0.0065
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Schistosoma mansoni regulator of G protein signaling 0.0916 0.1567 0.1551
Brugia malayi Protein kinase domain containing protein 0.0061 0.0045 0.0032
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0107 0.0125 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0084 0.0085 0.0497
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0084 0.0085 0.0264
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0445 0.2805
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0045 0.0039
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0084 0.0085 0.0087
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0061 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0181 0.0258 0.0255
Echinococcus granulosus regulator of G protein signaling 3 0.0916 0.1567 0.1861
Echinococcus granulosus Oxysterol binding protein 11 0.0084 0.0085 0.0087
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0045 0.024
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0084 0.0085 0.4999
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0045 0.024
Plasmodium falciparum calcium-dependent protein kinase 7 0.0107 0.0125 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0061 0.0045 0.0039
Trichomonas vaginalis protein kinase atn1, putative 0.0061 0.0045 0.024
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0045 0.0025
Schistosoma mansoni tyrosine kinase 0.0061 0.0045 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0085 0.0497
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0084 0.0085 0.0087
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0107 0.0125 1
Trypanosoma cruzi hypothetical protein 0.0084 0.0085 0.4999
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0045 0.024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.0083
Loa Loa (eye worm) hypothetical protein 0.0413 0.0671 0.0669
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.0045 0.0039
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.4732 0.8368 0.8368
Trichomonas vaginalis TK family protein kinase 0.0061 0.0045 0.024
Echinococcus multilocularis actin binding protein anillin 0.0084 0.0085 0.0087
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0045 0.0025
Echinococcus granulosus Pleckstrin y 0.0084 0.0085 0.0087
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0084 0.0085 0.0083
Echinococcus multilocularis raf serine:threonine protein kinase 0.0061 0.0045 0.0039

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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